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Home > Fluorides > 122799-38-6
122799-38-6 | Uridine, 2'-deoxy-2'-fluoro-5-methyl-
CAS No: 122799-38-6 Catalog No: AG000JI7 MDL No:MFCD03788702
Product Description
Catalog Number:
AG000JI7
Chemical Name:
Uridine, 2'-deoxy-2'-fluoro-5-methyl-
CAS Number:
122799-38-6
Molecular Formula:
C10H13FN2O5
Molecular Weight:
260.2190
MDL Number:
MFCD03788702
IUPAC Name:
1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
InChI:
InChI=1S/C10H13FN2O5/c1-4-2-13(10(17)12-8(4)16)9-6(11)7(15)5(3-14)18-9/h2,5-7,9,14-15H,3H2,1H3,(H,12,16,17)/t5-,6-,7-,9-/m1/s1
InChI Key:
GBBJCSTXCAQSSJ-JXOAFFINSA-N
SMILES:
OC[C@H]1O[C@H]([C@@H]([C@@H]1O)F)n1cc(C)c(=O)[nH]c1=O
Properties
Complexity:
413
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
4
Defined Bond Stereocenter Count:
0
Exact Mass:
260.081g/mol
Formal Charge:
0
Heavy Atom Count:
18
Hydrogen Bond Acceptor Count:
6
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
260.221g/mol
Monoisotopic Mass:
260.081g/mol
Rotatable Bond Count:
2
Topological Polar Surface Area:
99.1A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.9
Literature
| Title | Journal |
|---|---|
| Biochemistry and biology of 2'-Fluoro-2'-deoxythymidine (FT), a putative highly selective substrate for thymidine kinase type 2 (TK2). | Current radiopharmaceuticals 20120101 |
| An RNA aptamer that specifically binds pancreatic adenocarcinoma up-regulated factor inhibits migration and growth of pancreatic cancer cells. | Cancer letters 20111226 |
| Inhibition of cell proliferation by an anti-EGFR aptamer. | PloS one 20110101 |
| 3D-QSAR studies on antitubercular thymidine monophosphate kinase inhibitors based on different alignment methods. | Bioorganic & medicinal chemistry letters 20060215 |
| Synthesis and in vitro anti-mycobacterial activity of 5-substituted pyrimidine nucleosides. | Bioorganic & medicinal chemistry 20051215 |
| Synthesis and anti-viral activity of a series of d- and l-2'-deoxy-2'-fluororibonucleosides in the subgenomic HCV replicon system. | Bioorganic & medicinal chemistry 20050301 |
| PET imaging of cellular proliferation. | Radiologic clinics of North America 20050101 |
| Distribution of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) uracil in mice bearing colorectal cancer xenografts: rationale for therapeutic use and as a positron emission tomography probe for thymidylate synthase. | Clinical cancer research : an official journal of the American Association for Cancer Research 20041001 |
| Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase. | Bioorganic & medicinal chemistry letters 20030915 |
| A new synthesis of 9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)guanine (AraF-G). | Nucleosides, nucleotides & nucleic acids 20030101 |
| [Study of anti-HIV activity of azidothymidine and fluorothymidine 5'-phosphonates]. | Molekuliarnaia biologiia 19940101 |
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