200,000+ products from a single source!
sales@angenechem.com
1224844-38-5 | 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-(2-amino-5-benzoxazolyl)-1-(1-methylethyl)-
CAS No: 1224844-38-5 Catalog No: AG0017AM MDL No:MFCD22124893
Product Description
Catalog Number:
AG0017AM
Chemical Name:
1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-(2-amino-5-benzoxazolyl)-1-(1-methylethyl)-
CAS Number:
1224844-38-5
Molecular Formula:
C15H15N7O
Molecular Weight:
309.3259
MDL Number:
MFCD22124893
IUPAC Name:
5-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine
InChI:
InChI=1S/C15H15N7O/c1-7(2)22-14-11(13(16)18-6-19-14)12(21-22)8-3-4-10-9(5-8)20-15(17)23-10/h3-7H,1-2H3,(H2,17,20)(H2,16,18,19)
InChI Key:
GYLDXIAOMVERTK-UHFFFAOYSA-N
SMILES:
Nc1oc2c(n1)cc(cc2)c1nn(c2c1c(N)ncn2)C(C)C
UNII:
JGH0DF1U03
Properties
Complexity:
436
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
309.134g/mol
Formal Charge:
0
Heavy Atom Count:
23
Hydrogen Bond Acceptor Count:
7
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
309.333g/mol
Monoisotopic Mass:
309.134g/mol
Rotatable Bond Count:
2
Topological Polar Surface Area:
122A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.7
Literature
| Title | Journal |
|---|---|
| Dual mTOR inhibitor MLN0128 suppresses Merkel cell carcinoma (MCC) xenograft tumor growth. | Oncotarget 20160209 |
| Dual mTORC1/2 and HER2 blockade results in antitumor activity in preclinical models of breast cancer resistant to anti-HER2 therapy. | Clinical cancer research : an official journal of the American Association for Cancer Research 20120501 |
| The translational landscape of mTOR signalling steers cancer initiation and metastasis. | Nature 20120222 |
| ATP-competitive inhibitors of mTOR: an update. | Current medicinal chemistry 20110101 |
| mTOR Mediated Anti-Cancer Drug Discovery. | Drug discovery today. Therapeutic strategies 20090101 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.