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122384-88-7 | L-Tyrosinamide, L-lysyl-L-cysteinyl-L-asparaginyl-L-threonyl-L-alanyl-L-threonyl-L-cysteinyl-L-alanyl-L-threonyl-L-glutaminyl-L-arginyl-L-leucyl-L-alanyl-L-asparaginyl-L-phenylalanyl-L-leucyl-L-valyl-L-histidyl-L-seryl-L-seryl-L-asparaginyl-L-asparaginyl-L-phenylalanylglycyl-L-alanyl-L-isoleucyl-L-leucyl-L-seryl-L-seryl-L-threonyl-L-asparaginyl-L-valylglycyl-L-seryl-L-asparaginyl-L-threonyl-, cyclic (2→7)-disulfide
CAS No: 122384-88-7 Catalog No: AG00176K MDL No:MFCD00081345
Product Description
Catalog Number:
AG00176K
Chemical Name:
L-Tyrosinamide, L-lysyl-L-cysteinyl-L-asparaginyl-L-threonyl-L-alanyl-L-threonyl-L-cysteinyl-L-alanyl-L-threonyl-L-glutaminyl-L-arginyl-L-leucyl-L-alanyl-L-asparaginyl-L-phenylalanyl-L-leucyl-L-valyl-L-histidyl-L-seryl-L-seryl-L-asparaginyl-L-asparaginyl-L-phenylalanylglycyl-L-alanyl-L-isoleucyl-L-leucyl-L-seryl-L-seryl-L-threonyl-L-asparaginyl-L-valylglycyl-L-seryl-L-asparaginyl-L-threonyl-, cyclic (2→7)-disulfide
CAS Number:
122384-88-7
Molecular Formula:
C165H261N51O55S2
Molecular Weight:
3903.2765
MDL Number:
MFCD00081345
IUPAC Name:
(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-4-amino-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-4-amino-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]-2-[[(2S,3R)-2-[[(2S)-2-[[(4R,7S,10S,13S,16S,19R)-16-(2-amino-2-oxoethyl)-19-[[(2S)-2,6-diaminohexanoyl]amino]-7,13-bis[(1R)-1-hydroxyethyl]-10-methyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]amino]propanoyl]amino]-3-hydroxybutanoyl]amino]pentanediamide
InChI:
InChI=1S/C165H261N51O55S2/c1-22-75(12)124(159(266)200-95(47-71(4)5)140(247)203-108(64-219)153(260)206-110(66-221)154(261)216-129(84(21)226)163(270)202-105(58-119(174)234)147(254)209-122(73(8)9)157(264)181-61-121(236)187-106(62-217)150(257)198-103(56-117(172)232)148(255)215-128(83(20)225)162(269)190-93(130(175)237)49-87-38-40-89(227)41-39-87)211-132(239)76(13)183-120(235)60-180-136(243)97(50-85-32-25-23-26-33-85)194-144(251)101(54-115(170)230)196-145(252)102(55-116(171)231)197-151(258)107(63-218)205-152(259)109(65-220)204-142(249)99(52-88-59-178-69-182-88)201-158(265)123(74(10)11)210-146(253)96(48-72(6)7)193-141(248)98(51-86-34-27-24-28-35-86)195-143(250)100(53-114(169)229)191-131(238)77(14)184-139(246)94(46-70(2)3)192-137(244)91(37-31-45-179-165(176)177)188-138(245)92(42-43-113(168)228)189-161(268)126(81(18)223)212-133(240)78(15)185-155(262)111-67-272-273-68-112(207-135(242)90(167)36-29-30-44-166)156(263)199-104(57-118(173)233)149(256)214-125(80(17)222)160(267)186-79(16)134(241)213-127(82(19)224)164(271)208-111/h23-28,32-35,38-41,59,69-84,90-112,122-129,217-227H,22,29-31,36-37,42-58,60-68,166-167H2,1-21H3,(H2,168,228)(H2,169,229)(H2,170,230)(H2,171,231)(H2,172,232)(H2,173,233)(H2,174,234)(H2,175,237)(H,178,182)(H,180,243)(H,181,264)(H,183,235)(H,184,246)(H,185,262)(H,186,267)(H,187,236)(H,188,245)(H,189,268)(H,190,269)(H,191,238)(H,192,244)(H,193,248)(H,194,251)(H,195,250)(H,196,252)(H,197,258)(H,198,257)(H,199,263)(H,200,266)(H,201,265)(H,202,270)(H,203,247)(H,204,249)(H,205,259)(H,206,260)(H,207,242)(H,208,271)(H,209,254)(H,210,253)(H,211,239)(H,212,240)(H,213,241)(H,214,256)(H,215,255)(H,216,261)(H4,176,177,179)/t75-,76-,77-,78-,79-,80+,81+,82+,83+,84+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,122-,123-,124-,125-,126-,127-,128-,129-/m0/s1
InChI Key:
PLOPBXQQPZYQFA-AXPWDRQUSA-N
SMILES:
NCCCC[C@@H](C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CC(=O)N)[C@H](O)C)C)[C@H](O)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N)Cc1ccc(cc1)O)[C@H](O)C)CC(=O)N)CO)C(C)C)CC(=O)N)[C@H](O)C)CO)CO)CC(C)C)[C@H](CC)C)C)Cc1ccccc1)CC(=O)N)CC(=O)N)CO)CO)Cc1nc[nH]c1)C(C)C)CC(C)C)Cc1ccccc1)CC(=O)N)C)CC(C)C)CCCNC(=N)N)CCC(=O)N)[C@H](O)C)C)N
Properties
Complexity:
9390
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
41
Defined Bond Stereocenter Count:
0
Exact Mass:
3901.867g/mol
Formal Charge:
0
Heavy Atom Count:
273
Hydrogen Bond Acceptor Count:
61
Hydrogen Bond Donor Count:
61
Isotope Atom Count:
0
Molecular Weight:
3903.325g/mol
Monoisotopic Mass:
3900.864g/mol
Rotatable Bond Count:
115
Topological Polar Surface Area:
1810A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-18.7
Literature
| Title | Journal |
|---|---|
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| Translational control of glucose-induced islet amyloid polypeptide production in pancreatic islets. | Endocrinology 20120501 |
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| Accumulation of intrahepatic islet amyloid in a nonhuman primate transplant model. | Endocrinology 20120401 |
| Membrane disruption and early events in the aggregation of the diabetes related peptide IAPP from a molecular perspective. | Accounts of chemical research 20120320 |
| Silibinin inhibits the toxic aggregation of human islet amyloid polypeptide. | Biochemical and biophysical research communications 20120316 |
| Amylin-leptin coadministration stimulates central histaminergic signaling in rats. | Brain research 20120309 |
| Unique example of amyloid aggregates stabilized by main chain H-bond instead of the steric zipper: molecular dynamics study of the amyloidogenic segment of amylin wild-type and mutants. | Journal of molecular modeling 20120301 |
| Morin hydrate inhibits amyloid formation by islet amyloid polypeptide and disaggregates amyloid fibers. | Protein science : a publication of the Protein Society 20120301 |
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| Protective effects of cleavage agents on INS-1 cells against h-IAPP-induced apoptosis. | Chemical communications (Cambridge, England) 20120114 |
| β-Amyloid protein (Aβ) and human amylin regulation of apoptotic genes occurs through the amylin receptor. | Apoptosis : an international journal on programmed cell death 20120101 |
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| Histological staining of amyloid and pre-amyloid peptides and proteins in mouse tissue. | Methods in molecular biology (Clifton, N.J.) 20120101 |
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| Coffee components inhibit amyloid formation of human islet amyloid polypeptide in vitro: possible link between coffee consumption and diabetes mellitus. | Journal of agricultural and food chemistry 20111228 |
| [Investigation of amylin level changes among obese patients at different glucose metabolic states and effects of rosiglitazone intervention]. | Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20111218 |
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| Evidence for the role of hindbrain orexin-1 receptors in the control of meal size. | American journal of physiology. Regulatory, integrative and comparative physiology 20111201 |
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| Designed hairpin peptides interfere with amyloidogenesis pathways: fibril formation and cytotoxicity inhibition, interception of the preamyloid state. | Biochemistry 20110927 |
| Combined amylin-leptin treatment lowers blood pressure and adiposity in lean and obese rats. | International journal of obesity (2005) 20110901 |
| IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction. | Journal of immunology (Baltimore, Md. : 1950) 20110901 |
| The amylin peptide implicated in type 2 diabetes stimulates copper-mediated carbonyl group and ascorbate radical formation. | Free radical biology & medicine 20110815 |
| Butyrylcholinesterase interactions with amylin may protect pancreatic cells in metabolic syndrome. | Journal of cellular and molecular medicine 20110801 |
| Amylin and selective glucoregulatory peptide alterations during prolonged exercise. | Medicine and science in sports and exercise 20110801 |
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| Influence of high-fat feeding, diet-induced obesity, and hyperamylinemia on the sensitivity to acute amylin. | Physiology & behavior 20110725 |
| Hexafluoroisopropanol induces amyloid fibrils of islet amyloid polypeptide by enhancing both hydrophobic and electrostatic interactions. | The Journal of biological chemistry 20110708 |
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| Mechanism of amylin fibrillization enhancement by heparin. | The Journal of biological chemistry 20110701 |
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| To study various concentrations of magnesium and aluminium on amylin hormone conformation. | Pakistan journal of biological sciences : PJBS 20110601 |
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| The chaperone proteins HSP70, HSP40/DnaJ and GRP78/BiP suppress misfolding and formation of β-sheet-containing aggregates by human amylin: a potential role for defective chaperone biology in Type 2 diabetes. | The Biochemical journal 20101115 |
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| Enhanced weight loss following coadministration of pramlintide with sibutramine or phentermine in a multicenter trial. | Obesity (Silver Spring, Md.) 20100901 |
| Serum levels of proamylin and amylin in normal subjects and patients with impaired glucose regulation and type 2 diabetes mellitus. | Acta diabetologica 20100901 |
| The N-terminal fragment of human islet amyloid polypeptide is non-fibrillogenic in the presence of membranes and does not cause leakage of bilayers of physiologically relevant lipid composition. | Biochimica et biophysica acta 20100901 |
| Exendin-4 protects pancreatic beta cells from human islet amyloid polypeptide-induced cell damage: potential involvement of AKT and mitochondria biogenesis. | Diabetes, obesity & metabolism 20100901 |
| Basal plasma levels of insulin, leptin, ghrelin, and amylin do not signal adiposity in rats recovering from forced overweight. | Endocrinology 20100901 |
| The effect of curcumin on human islet amyloid polypeptide misfolding and toxicity. | Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 20100901 |
| Central amylin acts as an adiposity signal to control body weight and energy expenditure. | Physiology & behavior 20100804 |
| Oleuropein aglycon prevents cytotoxic amyloid aggregation of human amylin. | The Journal of nutritional biochemistry 20100801 |
| Insights into amylin-leptin synergy. | Trends in endocrinology and metabolism: TEM 20100801 |
| Pathologic changes and glucose homeostasis according to expression of human islet amyloid polypeptide in type 2 diabetic patients. | The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20100801 |
| Up-regulated pancreatic tissue microRNA-375 associates with human type 2 diabetes through beta-cell deficit and islet amyloid deposition. | Pancreas 20100801 |
| Noradrenergic neurons of the area postrema mediate amylin's hypophagic action. | American journal of physiology. Regulatory, integrative and comparative physiology 20100801 |
| Residue-specific, real-time characterization of lag-phase species and fibril growth during amyloid formation: a combined fluorescence and IR study of p-cyanophenylalanine analogs of islet amyloid polypeptide. | Journal of molecular biology 20100723 |
| The sulfated triphenyl methane derivative acid fuchsin is a potent inhibitor of amyloid formation by human islet amyloid polypeptide and protects against the toxic effects of amyloid formation. | Journal of molecular biology 20100716 |
| Brainstem mechanisms of amylin-induced anorexia. | Physiology & behavior 20100714 |
| Role of zinc in human islet amyloid polypeptide aggregation. | Journal of the American Chemical Society 20100707 |
| Differences between amyloid toxicity in alpha and beta cells in human and mouse islets and the role of caspase-3. | Diabetologia 20100701 |
| Identification of central projections from amylin-activated neurons to the lateral hypothalamus. | Brain research 20100602 |
| Increased secretion of amylin in women with polycystic ovary syndrome. | Fertility and sterility 20100601 |
| Oligomers of beta-amyloid are sequestered into and seed new plaques in the brains of an AD mouse model. | Experimental neurology 20100601 |
| Superior appetite hormone profile after equivalent weight loss by gastric bypass compared to gastric banding. | Obesity (Silver Spring, Md.) 20100601 |
| Postprandial response of plasma insulin, amylin and acylated ghrelin to various test meals in lean and obese cats. | The British journal of nutrition 20100601 |
| The role of amylin in the control of energy homeostasis. | American journal of physiology. Regulatory, integrative and comparative physiology 20100601 |
| Adjunct therapy for type 1 diabetes mellitus. | Nature reviews. Endocrinology 20100601 |
| Effect of the disulfide bond on the monomeric structure of human amylin studied by combined Hamiltonian and temperature replica exchange molecular dynamics simulations. | The journal of physical chemistry. B 20100527 |
| Multi-hormonal weight loss combinations in diet-induced obese rats: therapeutic potential of cholecystokinin? | Physiology & behavior 20100511 |
| Amylin reduces plasma glucagon concentration in cats. | Veterinary journal (London, England : 1997) 20100501 |
| Do the actions of glucagon-like peptide-1 on gastric emptying, appetite, and food intake involve release of amylin in humans? | The Journal of clinical endocrinology and metabolism 20100501 |
| In situ misfolding of human islet amyloid polypeptide at interfaces probed by vibrational sum frequency generation. | Journal of the American Chemical Society 20100421 |
| The threshold of amylin-induced anorexia is lower in chicks selected for low compared to high juvenile body weight. | Behavioural brain research 20100402 |
| Meal-induced hormone responses in a rat model of Roux-en-Y gastric bypass surgery. | Endocrinology 20100401 |
| Abeta and human amylin share a common toxicity pathway via mitochondrial dysfunction. | Proteomics 20100401 |
| Ester to amide switch peptides provide a simple method for preparing monomeric islet amyloid polypeptide under physiologically relevant conditions and facilitate investigations of amyloid formation. | Journal of the American Chemical Society 20100331 |
| The role of gut hormones in the regulation of body weight and energy homeostasis. | Molecular and cellular endocrinology 20100325 |
| Reduced amylin levels are associated with low bone mineral density in women with anorexia nervosa. | Bone 20100301 |
| Amylin(1-8) is devoid of anabolic activity in bone. | Calcified tissue international 20100301 |
| The role of pramlintide for weight loss. | The Annals of pharmacotherapy 20100301 |
| Sphingomyelinase dependent apoptosis of dendritic cells following treatment with amyloid peptides. | Journal of neuroimmunology 20100226 |
| Pancreatic beta-cell responses to GLP-1 after near-normalization of blood glucose in patients with type 2 diabetes. | Regulatory peptides 20100225 |
| Amylin suppresses acetic acid-induced visceral pain and spinal c-fos expression in the mouse. | Neuroscience 20100217 |
| Design and study of peptide-based inhibitors of amylin cytotoxicity. | Bioorganic & medicinal chemistry letters 20100215 |
| The ability of rodent islet amyloid polypeptide to inhibit amyloid formation by human islet amyloid polypeptide has important implications for the mechanism of amyloid formation and the design of inhibitors. | Biochemistry 20100209 |
| Solution structures of rat amylin peptide: simulation, theory, and experiment. | Biophysical journal 20100203 |
| Gastrointestinal peptides and bone health. | Current opinion in endocrinology, diabetes, and obesity 20100201 |
| Davalintide (AC2307), a novel amylin-mimetic peptide: enhanced pharmacological properties over native amylin to reduce food intake and body weight. | International journal of obesity (2005) 20100201 |
| Comparison of the post-meal glucose response to different insulin bolus waveforms in insulin pump- and pre-meal pramlintide-treated type 1 diabetes patients. | Diabetes technology & therapeutics 20100201 |
| Aggregation properties of the peptide fragments derived from the 17-29 region of the human and rat IAPP: a comparative study with two PEG-conjugated variants of the human sequence. | The journal of physical chemistry. B 20100121 |
| Molecular basis for the recognition and cleavages of IGF-II, TGF-alpha, and amylin by human insulin-degrading enzyme. | Journal of molecular biology 20100115 |
| Interaction of leptin and amylin in the long-term maintenance of weight loss in diet-induced obese rats. | Obesity (Silver Spring, Md.) 20100101 |
| Tetracycline treatment retards the onset and slows the progression of diabetes in human amylin/islet amyloid polypeptide transgenic mice. | Diabetes 20100101 |
| Fatty acids induce amylin expression and secretion by pancreatic beta-cells. | American journal of physiology. Endocrinology and metabolism 20100101 |
| Mechanisms of amylin/leptin synergy in rodent models. | Endocrinology 20100101 |
| Roles of amylin in satiation, adiposity and brain development. | Forum of nutrition 20100101 |
| Synthetic alpha-helix mimetics as agonists and antagonists of islet amyloid polypeptide aggregation. | Angewandte Chemie (International ed. in English) 20100101 |
| Microwave assisted SPPS of amylin and its toxicity of the pure product to RIN-5F cells. | Biopolymers 20100101 |
| Managing highly insulin-resistant diabetes mellitus: weight loss approaches and medical management. | Postgraduate medicine 20100101 |
| Amylin. Insulin's super sidekick. | Diabetes self-management 20100101 |
| Evidence for a partially structured state of the amylin monomer. | Biophysical journal 20091202 |
| Central amylin expression and its induction in rat dams. | Journal of neurochemistry 20091201 |
| Obesity treatment: novel peripheral targets. | British journal of clinical pharmacology 20091201 |
| Pharmacologic management of the older patient with type 2 diabetes mellitus. | The American journal of geriatric pharmacotherapy 20091201 |
| Impaired processing of human pro-islet amyloid polypeptide is not a causative factor for fibril formation or membrane damage in vitro. | Biochemistry 20091124 |
| Annexin A5 directly interacts with amyloidogenic proteins and reduces their toxicity. | Biochemistry 20091110 |
| Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects. | American journal of physiology. Endocrinology and metabolism 20091101 |
| Age dependence of glucose tolerance in adult KK-Ay mice, a model of non-insulin dependent diabetes mellitus. | Lab animal 20091101 |
| A pilot trial of pramlintide home usage in adolescents with type 1 diabetes. | Pediatrics 20091101 |
| Cholesterol regulates assembly of human islet amyloid polypeptide on model membranes. | Journal of molecular biology 20091030 |
| Gut hormones: implications for the treatment of obesity. | Pharmacology & therapeutics 20091001 |
| It takes two to tango: combined amylin/leptin agonism as a potential approach to obesity drug development. | Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20091001 |
| Ganglioside-induced amyloid formation by human islet amyloid polypeptide in lipid rafts. | FEBS letters 20090903 |
| Pramlintide lowered glucose excursions and was well-tolerated in adolescents with type 1 diabetes: results from a randomized, single-blind, placebo-controlled, crossover study. | The Journal of pediatrics 20090901 |
| Randomized comparison of pramlintide or mealtime insulin added to basal insulin treatment for patients with type 2 diabetes. | Diabetes care 20090901 |
| Enhanced weight loss with pramlintide/metreleptin: an integrated neurohormonal approach to obesity pharmacotherapy. | Obesity (Silver Spring, Md.) 20090901 |
| Pramlintide in pediatric type 1 diabetes. | The Journal of pediatrics 20090901 |
| Amylin prevents TRAIL-mediated apoptotic effects of reserpine in the rat gastric mucosa. | Peptides 20090801 |
| Dynamics of beta-cell turnover: evidence for beta-cell turnover and regeneration from sources of beta-cells other than beta-cell replication in the HIP rat. | American journal of physiology. Endocrinology and metabolism 20090801 |
| How does treatment satisfaction work?: Modeling determinants of treatment satisfaction and preference. | Diabetes care 20090801 |
| Vaspin and amylin are expressed in human and rat placenta and regulated by nutritional status. | Histology and histopathology 20090801 |
| Effects of amylin on bone development and egg production in hens. | Poultry science 20090801 |
| Solution state structures of human pancreatic amylin and pramlintide. | Protein engineering, design & selection : PEDS 20090801 |
| Elucidating the mechanism of lipid membrane-induced IAPP fibrillogenesis and its inhibition by the red wine compound resveratrol: a synchrotron X-ray reflectivity study. | Journal of the American Chemical Society 20090715 |
| Phycocyanin protects INS-1E pancreatic beta cells against human islet amyloid polypeptide-induced apoptosis through attenuating oxidative stress and modulating JNK and p38 mitogen-activated protein kinase pathways. | The international journal of biochemistry & cell biology 20090701 |
| Diet-derived nutrients mediate the inhibition of hypothalamic NPY neurons in the arcuate nucleus of mice during refeeding. | American journal of physiology. Regulatory, integrative and comparative physiology 20090701 |
| Beneficial endocrine but adverse exocrine effects of sitagliptin in the human islet amyloid polypeptide transgenic rat model of type 2 diabetes: interactions with metformin. | Diabetes 20090701 |
| Changes in gene expression and morphology of mouse embryonic stem cells on differentiation into insulin-producing cells in vitro and in vivo. | Diabetes/metabolism research and reviews 20090701 |
| Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process. | Protein science : a publication of the Protein Society 20090701 |
| Sphingomyelinase dependent apoptosis following treatment of pancreatic beta-cells with amyloid peptides Abeta(1-42) or IAPP. | Apoptosis : an international journal on programmed cell death 20090701 |
| Amyloidogenic propensities and conformational properties of ProIAPP and IAPP in the presence of lipid bilayer membranes. | Journal of molecular biology 20090626 |
| Three-dimensional structure and orientation of rat islet amyloid polypeptide protein in a membrane environment by solution NMR spectroscopy. | Journal of the American Chemical Society 20090617 |
| Sequence and crowding effects in the aggregation of a 10-residue fragment derived from islet amyloid polypeptide. | Biophysical journal 20090603 |
| Reducing postprandial hyperglycemia with adjuvant premeal pramlintide and postmeal insulin in children with type 1 diabetes mellitus. | Pediatric diabetes 20090601 |
| Amyloid inhibitors enhance survival of cultured human islets. | Biochimica et biophysica acta 20090601 |
| Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress. | Diabetologia 20090601 |
| Insulin is a kinetic but not a thermodynamic inhibitor of amylin aggregation. | The FEBS journal 20090601 |
| New therapeutic agents for diabetes mellitus: implications for anesthetic management. | Anesthesia and analgesia 20090601 |
| [The effects of amylin on the islet beta-cells voltage-gated L-calcium channels in rats]. | Zhonghua nei ke za zhi 20090601 |
| Fluorescence microscopy studies on islet amyloid polypeptide fibrillation at heterogeneous and cellular membrane interfaces and its inhibition by resveratrol. | FEBS letters 20090506 |
| Twenty-four-hour simultaneous subcutaneous Basal-bolus administration of insulin and amylin in adolescents with type 1 diabetes decreases postprandial hyperglycemia. | The Journal of clinical endocrinology and metabolism 20090501 |
| Dynamic alpha-helix structure of micelle-bound human amylin. | The Journal of biological chemistry 20090501 |
| Structure-function relationships in peptoids: recent advances toward deciphering the structural requirements for biological function. | Organic & biomolecular chemistry 20090421 |
| New potential adjuncts to treatment of children with type 1 diabetes mellitus. | Pediatric research 20090401 |
| Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis. | Diabetologia 20090401 |
| Successful versus failed adaptation to high-fat diet-induced insulin resistance: the role of IAPP-induced beta-cell endoplasmic reticulum stress. | Diabetes 20090401 |
| Common features between diabetes mellitus and Alzheimer's disease. | Cellular and molecular life sciences : CMLS 20090401 |
| Induction of negative curvature as a mechanism of cell toxicity by amyloidogenic peptides: the case of islet amyloid polypeptide. | Journal of the American Chemical Society 20090401 |
| Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. | Diabetes 20090401 |
| Control of food intake and energy expenditure by amylin-therapeutic implications. | International journal of obesity (2005) 20090401 |
| Gut peptides in the control of food intake. | International journal of obesity (2005) 20090401 |
| Minimal reduction in insulin dosage with pramlintide therapy when pretreatment near-normal glycemia is established and square-wave meal bolus is used. | Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20090401 |
| Glucocorticoids may trigger attacks in several types of periodic paralysis. | Neuromuscular disorders : NMD 20090301 |
| Implications of amylin receptor agonism: integrated neurohormonal mechanisms and therapeutic applications. | Archives of neurology 20090301 |
| Two-dimensional infrared spectroscopy provides evidence of an intermediate in the membrane-catalyzed assembly of diabetic amyloid. | The journal of physical chemistry. B 20090226 |
| Inhibiting islet amyloid polypeptide fibril formation by the red wine compound resveratrol. | Chembiochem : a European journal of chemical biology 20090213 |
| Biphasic induction of Pdx1 in mouse and human embryonic stem cells can mimic development of pancreatic beta-cells. | Stem cells (Dayton, Ohio) 20090201 |
| Adoptive transfer of syngeneic bone marrow-derived cells in mice with obesity-induced diabetes: selenoorganic antioxidant ebselen restores stem cell competence. | The American journal of pathology 20090201 |
| Amyloid formation results in recurrence of hyperglycaemia following transplantation of human IAPP transgenic mouse islets. | Diabetologia 20090101 |
| Amyloid oligomers in diabetic and nondiabetic human pancreas. | Translational research : the journal of laboratory and clinical medicine 20090101 |
| Insulin analog therapy: improving the match with physiologic insulin secretion. | The Journal of the American Osteopathic Association 20090101 |
| Psychometric properties of an instrument for assessing treatment satisfaction associated with pramlintide use. | The Diabetes educator 20090101 |
| Overlapping double turn conformations adopted by tetrapeptides containing non-coded alpha-amino isobutyric acid (Aib) and formation of tape-like structures through supramolecular helix mediated self-assembly. | Protein and peptide letters 20090101 |
| [Drug treatment of insulin resistance]. | Revue medicale de Bruxelles 20090101 |
| Continuous subcutaneous pramlintide infusion therapy in patients with type 1 diabetes: observations from a pilot study. | Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20090101 |
| Long-term metabolic and hormonal effects of exenatide on islet transplant recipients with allograft dysfunction. | Cell transplantation 20090101 |
| The perspectives of adjunctive drugs usage in the treatment of glucose metabolism disturbances in adolescent patients. | Pediatric endocrinology, diabetes, and metabolism 20090101 |
| Structures of rat and human islet amyloid polypeptide IAPP(1-19) in micelles by NMR spectroscopy. | Biochemistry 20081202 |
| A single mutation in the nonamyloidogenic region of islet amyloid polypeptide greatly reduces toxicity. | Biochemistry 20081202 |
| Calcium elevation in mouse pancreatic beta cells evoked by extracellular human islet amyloid polypeptide involves activation of the mechanosensitive ion channel TRPV4. | Diabetologia 20081201 |
| Gastric emptying and postprandial glucose excursions in adolescents with type 1 diabetes. | Pediatric diabetes 20081201 |
| Impaired hyperglycemia-induced delay in gastric emptying in patients with type 1 diabetes deficient for islet amyloid polypeptide. | Diabetes care 20081201 |
| Diabetes distress and its association with clinical outcomes in patients with type 2 diabetes treated with pramlintide as an adjunct to insulin therapy. | Diabetes technology & therapeutics 20081201 |
| Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptors. | Endocrinology 20081101 |
| Amylin-mediated restoration of leptin responsiveness in diet-induced obesity: magnitude and mechanisms. | Endocrinology 20081101 |
| Polyphenol-induced dissociation of various amyloid fibrils results in a methionine-independent formation of ROS. | Biochimica et biophysica acta 20081101 |
| Hormone-based therapies in the regulation of fuel metabolism and body weight. | Expert opinion on biological therapy 20081101 |
| Spontaneous diabetes in hemizygous human amylin transgenic mice that developed neither islet amyloid nor peripheral insulin resistance. | Diabetes 20081001 |
| Pramlintide reduces the risks associated with glucose variability in type 1 diabetes. | Diabetes technology & therapeutics 20081001 |
| Interaction of membrane-bound islet amyloid polypeptide with soluble and crystalline insulin. | Protein science : a publication of the Protein Society 20081001 |
| Amylin proprotein processing generates progressively more amyloidogenic peptides that initially sample the helical state. | Biochemistry 20080916 |
| Molecular characterization of calcitonin gene-related peptide (CGRP) related peptides (CGRP, amylin, adrenomedullin and adrenomedullin-2/intermedin) in goldfish (Carassius auratus): cloning and distribution. | Peptides 20080901 |
| Atomic structure of the cross-beta spine of islet amyloid polypeptide (amylin). | Protein science : a publication of the Protein Society 20080901 |
| Sustained weight loss following 12-month pramlintide treatment as an adjunct to lifestyle intervention in obesity. | Diabetes care 20080901 |
| Antiobesity effects of the beta-cell hormone amylin in combination with phentermine or sibutramine in diet-induced obese rats. | International journal of obesity (2005) 20080801 |
| The use of exenatide in islet transplant recipients with chronic allograft dysfunction: safety, efficacy, and metabolic effects. | Transplantation 20080715 |
| A biophysical characterization of the peptide drug pramlintide (AC137) using empirical phase diagrams. | Journal of pharmaceutical sciences 20080701 |
| Amylin peptide is increased in preterm neonates with feed intolerance. | Archives of disease in childhood. Fetal and neonatal edition 20080701 |
| Adrenomedullin-2/intermedin induces cAMP accumulation in dissociated rat spinal cord cells: evidence for the existence of a distinct class of sites of action. | Journal of molecular neuroscience : MN 20080701 |
| Human but not rat amylin shares neurotoxic properties with Abeta42 in long-term hippocampal and cortical cultures. | FEBS letters 20080625 |
| The fluorescent amino acid p-cyanophenylalanine provides an intrinsic probe of amyloid formation. | Chembiochem : a European journal of chemical biology 20080616 |
| Gastric emptying in response to IAPP and CCK in rats with subdiaphragmatic afferent vagotomy. | Regulatory peptides 20080605 |
| Phenolsulfonphthalein, but not phenolphthalein, inhibits amyloid fibril formation: implications for the modulation of amyloid self-assembly. | Biochemistry 20080603 |
| Rifampicin does not prevent amyloid fibril formation by human islet amyloid polypeptide but does inhibit fibril thioflavin-T interactions: implications for mechanistic studies of beta-cell death. | Biochemistry 20080603 |
| Differential responses of circulating amylin to high-fat vs. high-carbohydrate meal in healthy men. | Clinical endocrinology 20080601 |
| Cleavage agents for soluble oligomers of human islet amyloid polypeptide. | Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20080601 |
| Central and peripheral administration of amylin induces energy expenditure in anesthetized rats. | Peptides 20080601 |
| International Union of Pharmacology. LXIX. Status of the calcitonin gene-related peptide subtype 2 receptor. | Pharmacological reviews 20080601 |
| Type 2 diabetes: the many facets of care. | Home healthcare nurse 20080601 |
| Amyloid fiber formation and membrane disruption are separate processes localized in two distinct regions of IAPP, the type-2-diabetes-related peptide. | Journal of the American Chemical Society 20080521 |
| Leptin responsiveness restored by amylin agonism in diet-induced obesity: evidence from nonclinical and clinical studies. | Proceedings of the National Academy of Sciences of the United States of America 20080520 |
| Leptin does not directly regulate the pancreatic hormones amylin and pancreatic polypeptide: interventional studies in humans. | Diabetes care 20080501 |
| Increased secretion and expression of amylin in spontaneously diabetic Goto-Kakizaki rats treated with rhGLP-1 (7-36). | Acta pharmacologica Sinica 20080501 |
| Managed care perspective on three new agents for type 2 diabetes. | Journal of managed care pharmacy : JMCP 20080501 |
| Prevention and promotion effects of apolipoprotein E4 on amylin aggregation. | Biochemical and biophysical research communications 20080404 |
| Sedimentation studies on human amylin fail to detect low-molecular-weight oligomers. | Biophysical journal 20080401 |
| Differential secretion of satiety hormones with progression of obesity in JCR:LA-corpulent rats. | Obesity (Silver Spring, Md.) 20080401 |
| Beta-amyloid peptides 1-40betaA and 25-35betaA suppress human amylin-mediated death of RINm5F islet beta-cells with distinct actions on fibril formation. | Cell biology international 20080401 |
| New treatments of diabetes: the beta-amylin agonists. | Annales d'endocrinologie 20080401 |
| Pramlintide, the synthetic analogue of amylin: physiology, pathophysiology, and effects on glycemic control, body weight, and selected biomarkers of vascular risk. | Vascular health and risk management 20080401 |
| Amide inequivalence in the fibrillar assembly of islet amyloid polypeptide. | Protein engineering, design & selection : PEDS 20080301 |
| [Adjunctive therapies to glycaemic control of type 1 diabetes mellitus]. | Arquivos brasileiros de endocrinologia e metabologia 20080301 |
| Islet amyloid polypeptide forms rigid lipid-protein amyloid fibrils on supported phospholipid bilayers. | Journal of molecular biology 20080208 |
| Amylin causes anorexigenic effects via the hypothalamus and brain stem in chicks. | Regulatory peptides 20080207 |
| Pramlintide reduced markers of oxidative stress in the postprandial period in patients with type 2 diabetes. | Diabetes/metabolism research and reviews 20080201 |
| Fas-associated death receptor signaling evoked by human amylin in islet beta-cells. | Diabetes 20080201 |
| Copper(II) inhibits the formation of amylin amyloid in vitro. | Journal of inorganic biochemistry 20080201 |
| Beta-cell apoptosis in type 2 diabetes: quantitative and functional consequences. | Diabetes & metabolism 20080201 |
| The effects of C-terminal truncation of receptor activity modifying proteins on the induction of amylin receptor phenotype from human CTb receptors. | Regulatory peptides 20080110 |
| Fast conventional Fmoc solid-phase peptide synthesis with HCTU. | Journal of peptide science : an official publication of the European Peptide Society 20080101 |
| Clinical experience with the addition of pramlintide in patients with insulin-requiring type 2 diabetes. | Diabetes care 20080101 |
| Importance of changes in gastric emptying for postprandial plasma glucose fluxes in healthy humans. | American journal of physiology. Endocrinology and metabolism 20080101 |
| Effect of pramlintide as an adjunct to basal insulin on markers of cardiovascular risk in patients with type 2 diabetes. | Current medical research and opinion 20080101 |
| Emerging concepts in the medical and surgical treatment of obesity. | Frontiers of hormone research 20080101 |
| Optimizing diabetes treatment using an amylin analogue. | The Diabetes educator 20080101 |
| Optimizing treatment success with an amylin analogue. | The Diabetes educator 20080101 |
| Small-molecule inhibitors of islet amyloid polypeptide fibril formation. | Angewandte Chemie (International ed. in English) 20080101 |
| Recent insights in islet amyloid polypeptide-induced membrane disruption and its role in beta-cell death in type 2 diabetes mellitus. | Experimental diabetes research 20080101 |
| Human islet amyloid polypeptide transgenic mice: in vivo and ex vivo models for the role of hIAPP in type 2 diabetes mellitus. | Experimental diabetes research 20080101 |
| The role of the 14-20 domain of the islet amyloid polypeptide in amyloid formation. | Experimental diabetes research 20080101 |
| Real-time monitoring of apoptosis by caspase-3-like protease induced FRET reduction triggered by amyloid aggregation. | Experimental diabetes research 20080101 |
| Disturbed alpha-cell function in mice with beta-cell specific overexpression of human islet amyloid polypeptide. | Experimental diabetes research 20080101 |
| [Role of amylin in glucose homeostasis and its perspective use in diabetes management]. | Przeglad lekarski 20080101 |
| Transthyretin and amyloid in the islets of Langerhans in type-2 diabetes. | Experimental diabetes research 20080101 |
| New drugs for type 2 diabetes mellitus: what is their place in therapy? | Drugs 20080101 |
| [New therapies for diabetes: beyond injectable insulin and oral antidiabetics]. | Revista da Associacao Medica Brasileira (1992) 20080101 |
| Pramlintide in the treatment of diabetes mellitus. | BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 20080101 |
| Nano-scale imaging and dynamics of amylin-membrane interactions and its implication in type II diabetes mellitus. | Methods in cell biology 20080101 |
| Amyloid deposition in transplanted human pancreatic islets: a conceivable cause of their long-term failure. | Experimental diabetes research 20080101 |
| Importance of aggregated islet amyloid polypeptide for the progressive beta-cell failure in type 2 diabetes and in transplanted human islets. | Experimental diabetes research 20080101 |
| Desensitization and re-sensitization of CGRP receptor function in human neuroblastoma SK-N-MC cells. | European journal of pharmacology 20071222 |
| Fast Fmoc synthesis of hAmylin1-37 with pseudoproline assisted on-resin disulfide formation. | Journal of peptide science : an official publication of the European Peptide Society 20071201 |
| Combination therapy with amylin and peptide YY[3-36] in obese rodents: anorexigenic synergy and weight loss additivity. | Endocrinology 20071201 |
| Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide. | American journal of physiology. Endocrinology and metabolism 20071201 |
| The role of prandial pramlintide in the treatment of adolescents with type 1 diabetes. | Pediatric research 20071201 |
| Pharmacotherapy for obesity. | Current atherosclerosis reports 20071201 |
| Peptide conformation and supramolecular organization in amylin fibrils: constraints from solid-state NMR. | Biochemistry 20071127 |
| In-vitro and in-vivo antagonistic action of an anti-amylin Spiegelmer. | Neuroreport 20071119 |
| Pramlintide improved glycemic control and reduced weight in patients with type 2 diabetes using basal insulin. | Diabetes care 20071101 |
| Effects of intermittent intraperitoneal infusion of salmon calcitonin on food intake and adiposity in obese rats. | American journal of physiology. Regulatory, integrative and comparative physiology 20071101 |
| Inhibition of glycosaminoglycan synthesis and protein glycosylation with WAS-406 and azaserine result in reduced islet amyloid formation in vitro. | American journal of physiology. Cell physiology 20071101 |
| Pharmacological actions of the peptide hormone amylin in the long-term regulation of food intake, food preference, and body weight. | American journal of physiology. Regulatory, integrative and comparative physiology 20071101 |
| Amyloid formation by pro-islet amyloid polypeptide processing intermediates: examination of the role of protein heparan sulfate interactions and implications for islet amyloid formation in type 2 diabetes. | Biochemistry 20071030 |
| Insight into antidiabetic therapies: a report from the 43rd annual meeting of the European Association for the Study of Diabetes. | Timely topics in medicine. Cardiovascular diseases 20071024 |
| DPP-4 inhibition improves glucose tolerance and increases insulin and GLP-1 responses to gastric glucose in association with normalized islet topography in mice with beta-cell-specific overexpression of human islet amyloid polypeptide. | Regulatory peptides 20071004 |
| Fibrillogenic amylin evokes the apoptosis of human mesangial cells. | Diabetes research and clinical practice 20071001 |
| Effects of prior or concurrent food restriction on amylin-induced changes in body weight and body composition in high-fat-fed female rats. | American journal of physiology. Endocrinology and metabolism 20071001 |
| Diabetes mellitus in pancreatic cancer: is it a causal relationship? | American journal of surgery 20071001 |
| Effects of lactogen resistance and GH deficiency on mouse metabolism: pancreatic hormones, adipocytokines, and expression of adiponectin and insulin receptors. | Endocrine 20071001 |
| [The regulation of body mass and its relation to the development of obesity]. | Orvosi hetilap 20070930 |
| Histamine H1-receptors differentially mediate the action of amylin on hypothalamic neurons in control and in overweight rats. | Behavioural brain research 20070822 |
| Modulation of the satiating effect of amylin by central ghrelin, leptin and insulin. | Physiology & behavior 20070815 |
| Lesion of the lateral parabrachial nucleus attenuates the anorectic effect of peripheral amylin and CCK. | Brain research 20070808 |
| Progressive reduction in body weight after treatment with the amylin analog pramlintide in obese subjects: a phase 2, randomized, placebo-controlled, dose-escalation study. | The Journal of clinical endocrinology and metabolism 20070801 |
| Pramlintide treatment reduces 24-h caloric intake and meal sizes and improves control of eating in obese subjects: a 6-wk translational research study. | American journal of physiology. Endocrinology and metabolism 20070801 |
| Assessing treatment satisfaction in patients treated with pramlintide as an adjunct to insulin therapy. | Current medical research and opinion 20070801 |
| Amylin and its relation to insulin and lipids in obese children before and after weight loss. | Obesity (Silver Spring, Md.) 20070801 |
| Type 2 diabetes drug boom: is newer better? | The Johns Hopkins medical letter health after 50 20070801 |
| Copper-mediated formation of hydrogen peroxide from the amylin peptide: a novel mechanism for degeneration of islet cells in type-2 diabetes mellitus? | FEBS letters 20070724 |
| Protective effects of amylin on reserpine-induced gastric damage in the rat. | Pharmacological research 20070701 |
| Pharmacokinetics of an oral drug (acetaminophen) administered at various times relative to subcutaneous injection of pramlintide in subjects with type 2 diabetes. | Journal of clinical pharmacology 20070701 |
| Agonist-dependent consequences of proline to alanine substitution in the transmembrane helices of the calcitonin receptor. | British journal of pharmacology 20070701 |
| Amylin deposition in the kidney of patients with diabetic nephropathy. | Kidney international 20070701 |
| Are you up-to-date on diabetes medications? | Nursing 20070701 |
| Management of comorbid diabetes and cancer. | Oncology (Williston Park, N.Y.) 20070701 |
| Therapies for diabetes: pramlintide and exenatide. | American family physician 20070615 |
| The acute effect of amylin and salmon calcitonin on energy expenditure. | Physiology & behavior 20070608 |
| Longitudinal ultrastructure study of islet amyloid in the HIP rat model of type 2 diabetes mellitus. | Experimental biology and medicine (Maywood, N.J.) 20070601 |
| Cloning and expression of human islet amyloid polypeptide in cultured cells. | Biochemical and biophysical research communications 20070511 |
| Toxic human islet amyloid polypeptide (h-IAPP) oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP-induced beta-cell apoptosis in h-IAPP transgenic mice. | Diabetes 20070501 |
| Is pramlintide a safe and effective adjunct therapy for patients with type 1 diabetes? | Nature clinical practice. Endocrinology & metabolism 20070501 |
| Low-dose pramlintide reduced food intake and meal duration in healthy, normal-weight subjects. | Obesity (Silver Spring, Md.) 20070501 |
| Amylin S20G mutation in Mexican population. | Diabetes research and clinical practice 20070401 |
| Amylin and hypertension: association of an amylin -G132A gene mutation and hypertension in humans and amylin-induced endothelium dysfunction in rats. | The Journal of clinical endocrinology and metabolism 20070401 |
| Transformation of the amyloidogenic peptide amylin(20-29) into its corresponding peptoid and retropeptoid: access to both an amyloid inhibitor and template for self-assembled supramolecular tapes. | Bioorganic & medicinal chemistry letters 20070401 |
| Pramlintide as an adjunct to insulin in patients with type 2 diabetes in a clinical practice setting reduced A1C, postprandial glucose excursions, and weight. | Diabetes technology & therapeutics 20070401 |
| New drugs for the treatment of type 2 diabetes. | British journal of hospital medicine (London, England : 2005) 20070401 |
| Pramlintide acetate injection for the treatment of type 1 and type 2 diabetes mellitus. | Clinical therapeutics 20070401 |
| Aromatic interactions are not required for amyloid fibril formation by islet amyloid polypeptide but do influence the rate of fibril formation and fibril morphology. | Biochemistry 20070320 |
| Inhibitory effect of BIBN4096BS, CGRP(8-37), a CGRP antibody and an RNA-Spiegelmer on CGRP induced vasodilatation in the perfused and non-perfused rat middle cerebral artery. | British journal of pharmacology 20070301 |
| Diabetes drug update: how 4 new options stack up. | The Journal of family practice 20070301 |
| Leapin' lizards: Amylin targets diabetes and obesity via incretins. | Chemistry & biology 20070301 |
| Selective desulfurization of cysteine in the presence of Cys(Acm) in polypeptides obtained by native chemical ligation. | Organic letters 20070215 |
| Through the looking glass: current and future perspectives on the role of hormonal interplay in glucose homeostasis. | The Diabetes educator 20070201 |
| Direct detection of transient alpha-helical states in islet amyloid polypeptide. | Protein science : a publication of the Protein Society 20070101 |
| Neuropeptides of the islets of Langerhans: a peptidomics study. | General and comparative endocrinology 20070101 |
| Diet-derived nutrients modulate the effects of amylin on c-Fos expression in the area postrema and on food intake. | Neuroendocrinology 20070101 |
| Pharmacologic management of type 1 diabetes: a review for dentistry. | General dentistry 20070101 |
| Environmental factors differently affect human and rat IAPP: conformational preferences and membrane interactions of IAPP17-29 peptide derivatives. | Chemistry (Weinheim an der Bergstrasse, Germany) 20070101 |
| Bodyweight changes associated with antihyperglycaemic agents in type 2 diabetes mellitus. | Drug safety 20070101 |
| New therapies for diabetes. | Clinical cornerstone 20070101 |
| Role of endogenous amylin in glucagon secretion and gastric emptying in rats demonstrated with the selective antagonist, AC187. | Regulatory peptides 20061210 |
| Role of neuropeptides in appetite regulation and obesity--a review. | Neuropeptides 20061201 |
| Antiobesity effects of the beta-cell hormone amylin in diet-induced obese rats: effects on food intake, body weight, composition, energy expenditure, and gene expression. | Endocrinology 20061201 |
| An in vitro model of early islet amyloid polypeptide (IAPP) fibrillogenesis using human IAPP-transgenic mouse islets. | Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 20061201 |
| A novel analytical method for assessing glucose variability: using CGMS in type 1 diabetes mellitus. | Diabetes technology & therapeutics 20061201 |
| Pramlintide in the treatment of diabetes. | International journal of clinical practice 20061201 |
| Amylinergic control of food intake. | Physiology & behavior 20061130 |
| The role of amylin and related peptides in osteoporosis. | Clinica chimica acta; international journal of clinical chemistry 20061101 |
| Kinectin participates in microtubule-dependent hormone secretion in pancreatic islet beta-cells. | Cell biology international 20061101 |
| Clinical features and morphological characterization of 10 patients with noninsulinoma pancreatogenous hypoglycaemia syndrome (NIPHS). | Clinical endocrinology 20061101 |
| Adjunctive therapy with pramlintide in patients with type 1 or type 2 diabetes mellitus. | Pharmacotherapy 20061101 |
| Pramlintide: A new tool in diabetes management. | Current diabetes reports 20061101 |
| Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism. | Nature 20061019 |
| Synthesis and structural investigations of N-alkylated beta-peptidosulfonamide-peptide hybrids of the amyloidogenic amylin(20-29) sequence: Implications of supramolecular folding for the design of peptide-based bionanomaterials. | Organic & biomolecular chemistry 20061007 |
| Bombesin, but not amylin, blocks the orexigenic effect of peripheral ghrelin. | American journal of physiology. Regulatory, integrative and comparative physiology 20061001 |
| A double-blind, placebo-controlled trial assessing pramlintide treatment in the setting of intensive insulin therapy in type 1 diabetes. | Diabetes care 20061001 |
| Pramlintide in the management of insulin-using patients with type 2 and type 1 diabetes. | Vascular health and risk management 20060901 |
| Activation of activating transcription factor 2 by p38 MAP kinase during apoptosis induced by human amylin in cultured pancreatic beta-cells. | The FEBS journal 20060801 |
| The aggregation potential of human amylin determines its cytotoxicity towards islet beta-cells. | The FEBS journal 20060801 |
| The vasorelaxant effect of adrenomedullin, proadrenomedullin N-terminal 20 peptide and amylin in human skin. | Basic & clinical pharmacology & toxicology 20060801 |
| Pancreatic signals controlling food intake; insulin, glucagon and amylin. | Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20060729 |
| New diabetes drugs target gut hormones. | JAMA 20060726 |
| The role of neuropeptide Y, orexins, cocaine and amphetamine-related transcript, cholecystokinin, amylin and leptin in the regulation of feeding in fish. | Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20060701 |
| Beta-cell deficit due to increased apoptosis in the human islet amyloid polypeptide transgenic (HIP) rat recapitulates the metabolic defects present in type 2 diabetes. | Diabetes 20060701 |
| The organization of aromatic side groups in an amyloid fibril probed by solid-state 2H and 19F NMR spectroscopy. | Journal of the American Chemical Society 20060628 |
| Effects of amylin deficiency on trabecular bone in young mice are sex-dependent. | Calcified tissue international 20060601 |
| Increased plasma amylin in type 1 diabetic patients after kidney and pancreas transplantation: A sign of impaired beta-cell function? | Diabetes care 20060501 |
| Exenatide and pramlintide: new glucose-lowering agents for treating diabetes mellitus. | Cleveland Clinic journal of medicine 20060501 |
| What's new in clinical pharmacology and therapeutics. | WMJ : official publication of the State Medical Society of Wisconsin 20060501 |
| Recovery and purification of highly aggregation-prone disulfide-containing peptides: application to islet amyloid polypeptide. | Analytical biochemistry 20060415 |
| Binding of trypsin to fibrillar amyloid beta-protein. | Brain research 20060412 |
| A molecular dynamics approach to the structural characterization of amyloid aggregation. | Journal of molecular biology 20060407 |
| Diabetes: assessing the pipeline. | Atherosclerosis. Supplements 20060401 |
| Obesity drugs in clinical development. | Current opinion in investigational drugs (London, England : 2000) 20060401 |
| Newer therapeutic options for children with diabetes mellitus: theoretical and practical considerations. | Pediatric diabetes 20060401 |
| Practical considerations of new drugs: new choices for old problems. | The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists 20060401 |
| GABAA receptor antagonists prevent abnormalities in leptin, insulin and amylin actions on paraventricular hypothalamic neurons of overweight rats. | The European journal of neuroscience 20060301 |
| Emerging therapies mimicking the effects of amylin and glucagon-like peptide 1. | Diabetes care 20060201 |
| A look back at the most influential drug approvals of 2005. | The Nurse practitioner 20060201 |
| New drugs 06, part I. | Nursing 20060201 |
| Molecular structure of amyloid fibrils: insights from solid-state NMR. | Quarterly reviews of biophysics 20060201 |
| Effects of amylin on feeding of goldfish: interactions with CCK. | Regulatory peptides 20060115 |
| Destabilization of human IAPP amyloid fibrils by proline mutations outside of the putative amyloidogenic domain: is there a critical amyloidogenic domain in human IAPP? | Journal of molecular biology 20060113 |
| Role of islet amyloid in type 2 diabetes mellitus. | The international journal of biochemistry & cell biology 20060101 |
| Why does diabetes mellitus increase the risk of cardiovascular disease? | Acta medica Indonesiana 20060101 |
| New insights into glucose regulation. | The Diabetes educator 20060101 |
| Therapeutic options in development for management of diabetes: pharmacologic agents and new technologies. | Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20060101 |
| Deletions of genes encoding calcitonin/alpha-CGRP, amylin and calcitonin receptor have given new and unexpected insights into the function of calcitonin receptors and calcitonin receptor-like receptors in bone. | Journal of musculoskeletal & neuronal interactions 20060101 |
| The physiology of amylin and insulin: maintaining the balance between glucose secretion and glucose uptake. | The Diabetes educator 20060101 |
| Amylin replacement therapy in patients with insulin-requiring type 2 diabetes. | The Diabetes educator 20060101 |
| Use of pramlintide: the patient's perspective. | The Diabetes educator 20060101 |
| Amylin replacement therapy in patients with type 1 diabetes. | The Diabetes educator 20060101 |
| Islet amyloid polypeptide (IAPP) transgenic rodents as models for type 2 diabetes. | ILAR journal 20060101 |
| Diabetes basics. Exenatide and pramlintide. New meds on the block. | Diabetes self-management 20060101 |
| Update in the pharmacologic treatment of diabetes mellitus: focus on pramlintide and exenatide. | The Diabetes educator 20060101 |
| Amylin in the periphery II: An updated mini-review. | TheScientificWorldJournal 20060101 |
| The role of His-18 in amyloid formation by human islet amyloid polypeptide. | Biochemistry 20051213 |
| Amylin peptide levels are raised in infants of diabetic mothers. | Archives of disease in childhood 20051201 |
| Activation of peroxisome proliferator-activated receptor-gamma by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol 3'-kinase-dependent pathway. | The Journal of clinical endocrinology and metabolism 20051201 |
| Insulin analogues in children and teens with type 1 diabetes: advantages and caveats. | Pediatric clinics of North America 20051201 |
| Effect of amylin on prolactin release. | Neuro endocrinology letters 20051201 |
| Quantifying temporal glucose variability in diabetes via continuous glucose monitoring: mathematical methods and clinical application. | Diabetes technology & therapeutics 20051201 |
| Pramlintide acetate. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20051115 |
| Reduced ghrelin, islet amyloid polypeptide, and peptide YY expression in the stomach of gastrin-cholecystokinin knockout mice. | Endocrinology 20051001 |
| Thiol reducing compounds prevent human amylin-evoked cytotoxicity. | The FEBS journal 20051001 |
| Day-long subcutaneous infusion of exenatide lowers glycemia in patients with type 2 diabetes. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20051001 |
| Pramlintide in the treatment of type 1 and type 2 diabetes mellitus. | Clinical therapeutics 20051001 |
| Selective nucleotide-release from dense-core granules in insulin-secreting cells. | Journal of cell science 20050915 |
| Lipid membranes modulate the structure of islet amyloid polypeptide. | Biochemistry 20050913 |
| The effect of pramlintide on hormonal, metabolic or symptomatic responses to insulin-induced hypoglycaemia in patients with type 1 diabetes. | Diabetes, obesity & metabolism 20050901 |
| Pharmaceutical liquid crystals: the relevance of partially ordered systems. | Journal of pharmaceutical sciences 20050901 |
| Potential role of pancreatic and enteric hormones in regulating bone turnover. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20050901 |
| Amylin induces natriuresis by a central angiotensin-dependent mechanism. | Regulatory peptides 20050815 |
| Dose-response for inhibition by amylin of cholecystokinin-stimulated secretion of amylase and lipase in rats. | Regulatory peptides 20050815 |
| Enterostatin decreases postprandial pancreatic UCP2 mRNA levels and increases plasma insulin and amylin. | American journal of physiology. Endocrinology and metabolism 20050701 |
| Long-term treatment with rosiglitazone and metformin reduces the extent of, but does not prevent, islet amyloid deposition in mice expressing the gene for human islet amyloid polypeptide. | Diabetes 20050701 |
| Presence and function of the calcitonin gene-related peptide receptor on rat pial arteries investigated in vitro and in vivo. | Cephalalgia : an international journal of headache 20050601 |
| Pramlintide (symlin) for diabetes. | The Medical letter on drugs and therapeutics 20050523 |
| Effect of pramlintide on satiety and food intake in obese subjects and subjects with type 2 diabetes. | Diabetologia 20050501 |
| The parallel superpleated beta-structure as a model for amyloid fibrils of human amylin. | Journal of molecular biology 20050429 |
| Properties of pramlintide and insulin upon mixing. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20050415 |
| The role of amylin and glucagon in the dampening of glycemic excursions in children with type 1 diabetes. | Diabetes 20050401 |
| Adjunctive therapy with pramlintide lowers HbA1c without concomitant weight gain and increased risk of severe hypoglycemia in patients with type 1 diabetes approaching glycemic targets. | Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20050401 |
| Effects of pramlintide on postprandial glucose excursions and measures of oxidative stress in patients with type 1 diabetes. | Diabetes care 20050301 |
| Pancreatic amylin as a centrally acting satiating hormone. | Current drug targets 20050301 |
| Incorporation of pseudoproline derivatives allows the facile synthesis of human IAPP, a highly amyloidogenic and aggregation-prone polypeptide. | Organic letters 20050217 |
| Nucleation-dependent polymerization is an essential component of amyloid-mediated neuronal cell death. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20050202 |
| [S20G mutation of amylin gene--amyloid diabetes due to S20G amylin gene mutation]. | Nihon rinsho. Japanese journal of clinical medicine 20050201 |
| The regulation of amylin and insulin gene expression and secretion. | Pancreas 20050101 |
| Chronically administered islet amyloid polypeptide in rats serves as an adiposity inhibitor and regulates energy homeostasis. | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20050101 |
| Time-lapse atomic force microscopy in the characterization of amyloid-like fibril assembly and oligomeric intermediates. | Methods in molecular biology (Clifton, N.J.) 20050101 |
| New methods for researching accessory proteins. | Journal of molecular neuroscience : MN 20050101 |
| Amylin. Insulin's partner. | Diabetes self-management 20050101 |
| New drugs: exenatide, pramlintide acetate, and micafungin sodium. | Journal of the American Pharmacists Association : JAPhA 20050101 |
| Tissue expression and secretion of amylin. | Advances in pharmacology (San Diego, Calif.) 20050101 |
| Amylin and the integrated control of nutrient influx. | Advances in pharmacology (San Diego, Calif.) 20050101 |
| Inhibition of food intake. | Advances in pharmacology (San Diego, Calif.) 20050101 |
| Inhibition of gastric emptying. | Advances in pharmacology (San Diego, Calif.) 20050101 |
| Effects on digestive secretions. | Advances in pharmacology (San Diego, Calif.) 20050101 |
| Inhibition of glucagon secretion. | Advances in pharmacology (San Diego, Calif.) 20050101 |
| Inhibition of insulin secretion. | Advances in pharmacology (San Diego, Calif.) 20050101 |
| Effects on plasma glucose and lactate. | Advances in pharmacology (San Diego, Calif.) 20050101 |
| Effects in skeletal muscle. | Advances in pharmacology (San Diego, Calif.) 20050101 |
| Effects in liver. | Advances in pharmacology (San Diego, Calif.) 20050101 |
| Effects in fat. | Advances in pharmacology (San Diego, Calif.) 20050101 |
| Cardiovascular effects. | Advances in pharmacology (San Diego, Calif.) 20050101 |
| Renal effects. | Advances in pharmacology (San Diego, Calif.) 20050101 |
| Effects on bone. | Advances in pharmacology (San Diego, Calif.) 20050101 |
| Central nervous system and other effects. | Advances in pharmacology (San Diego, Calif.) 20050101 |
| Clinical studies. | Advances in pharmacology (San Diego, Calif.) 20050101 |
| Arcuate neurons of overweight rats differ in their responses to amylin from controls. | Neuroreport 20041222 |
| Role of aromatic interactions in amyloid formation by peptides derived from human Amylin. | Biochemistry 20041221 |
| Amylin agonists: a novel approach in the treatment of diabetes. | Diabetes 20041201 |
| GSK3 involvement in amylin signaling in isolated rat soleus muscle. | Peptides 20041201 |
| Transcriptional regulation of the IAPP gene in pancreatic beta-cells. | Biochimica et biophysica acta 20041124 |
| Inhibition of islet amyloid polypeptide fibril formation: a potential role for heteroaromatic interactions. | Biochemistry 20041116 |
| Identifying structural features of fibrillar islet amyloid polypeptide using site-directed spin labeling. | The Journal of biological chemistry 20041112 |
| Amylin replacement with pramlintide as an adjunct to insulin therapy improves long-term glycaemic and weight control in Type 1 diabetes mellitus: a 1-year, randomized controlled trial. | Diabetic medicine : a journal of the British Diabetic Association 20041101 |
| Amyloidogenicity and cytotoxicity of recombinant mature human islet amyloid polypeptide (rhIAPP). | The Journal of biological chemistry 20041008 |
| Intermedin, a novel calcitonin family peptide that exists in teleosts as well as in mammals: a comparison with other calcitonin/intermedin family peptides in vertebrates. | Peptides 20041001 |
| Atomic force microscopy reveals defects within mica supported lipid bilayers induced by the amyloidogenic human amylin peptide. | Journal of molecular biology 20040917 |
| Amylin receptor blockade stimulates food intake in rats. | American journal of physiology. Regulatory, integrative and comparative physiology 20040901 |
| Effect of pramlintide on symptom, catecholamine, and glucagon responses to hypoglycemia in healthy subjects. | Metabolism: clinical and experimental 20040901 |
| Phospholipid catalysis of diabetic amyloid assembly. | Journal of molecular biology 20040827 |
| Islet amyloid: a critical entity in the pathogenesis of type 2 diabetes. | The Journal of clinical endocrinology and metabolism 20040801 |
| Mutation at position -132 in the islet amyloid polypeptide ( IAPP) gene promoter enhances basal transcriptional activity through a new CRE-like binding site. | Diabetologia 20040701 |
| American Diabetes Association--64th Scientific Sessions. Targeting amylin. 4-8 June 2004, Orlando, FL, USA. | IDrugs : the investigational drugs journal 20040701 |
| In vitro autoradiographic localization of calcitonin and amylin binding sites in monkey brain. | Journal of chemical neuroanatomy 20040701 |
| Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes. | Diabetes 20040601 |
| Ghrelin and other glucoregulatory hormone responses to eccentric and concentric muscle contractions. | Endocrine 20040601 |
| Shared pathways of osteoblast mitogenesis induced by amylin, adrenomedullin, and IGF-1. | Biochemical and biophysical research communications 20040521 |
| Chronic infusion of the amylin antagonist AC 187 increases feeding in Zucker fa/fa rats but not in lean controls. | Physiology & behavior 20040501 |
| Seeding specificity in amyloid growth induced by heterologous fibrils. | The Journal of biological chemistry 20040423 |
| Effect of pramlintide on weight in overweight and obese insulin-treated type 2 diabetes patients. | Obesity research 20040401 |
| Human amylin oligomer growth and fibril elongation define two distinct phases in amyloid formation. | The Journal of biological chemistry 20040326 |
| Amylin-induced suppression of ANP secretion through receptors for CGRP1 and salmon calcitonin. | Regulatory peptides 20040315 |
| Amylin fasting plasma levels are decreased in patients with osteoporosis. | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20040301 |
| Extended life span is associated with insulin resistance in a transgenic mouse model of insulinoma secreting human islet amyloid polypeptide. | American journal of physiology. Endocrinology and metabolism 20040301 |
| Peptide sequence and amyloid formation; molecular simulations and experimental study of a human islet amyloid polypeptide fragment and its analogs. | Structure (London, England : 1993) 20040301 |
| Post-partum evaluation of amylin in lean patients with gestational diabetes mellitus. | Acta diabetologica 20040301 |
| Infusion of the amylin antagonist AC 187 into the area postrema increases food intake in rats. | Physiology & behavior 20040301 |
| ABri peptide associated with familial British dementia forms annular and ring-like protofibrillar structures. | Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 20040301 |
| Augmenting with amylin. | Science of aging knowledge environment : SAGE KE 20040218 |
| Pancreatic beta-cell granule peptides form heteromolecular complexes which inhibit islet amyloid polypeptide fibril formation. | The Biochemical journal 20040201 |
| Islet amyloid: a complication of islet dysfunction or an aetiological factor in Type 2 diabetes? | Diabetologia 20040201 |
| Increased risk of type 2 diabetes in Alzheimer disease. | Diabetes 20040201 |
| Aggregation of liposomes induced by the toxic peptides Alzheimer's Abetas, human amylin and prion (106-126): facilitation by membrane-bound GM1 ganglioside. | Peptides 20040201 |
| Peripheral amylin activates circumventricular organs expressing calcitonin receptor a/b subtypes and receptor-activity modifying proteins in the rat. | Brain research 20040130 |
| Structural characterisation of islet amyloid polypeptide fibrils. | Journal of molecular biology 20040130 |
| Calcitonin gene-related peptide-induced suppression of atrial natriuretic peptide release through receptors for CGRP1 but not for calcitonin and amylin. | European journal of pharmacology 20040112 |
| The mechanism of insulin action on islet amyloid polypeptide fiber formation. | Journal of molecular biology 20040102 |
| The anorectic hormone amylin contributes to feeding-related changes of neuronal activity in key structures of the gut-brain axis. | American journal of physiology. Regulatory, integrative and comparative physiology 20040101 |
| Pramlintide reduces postprandial glucose excursions when added to insulin lispro in subjects with type 2 diabetes: a dose-timing study. | Diabetes/metabolism research and reviews 20040101 |
| Neuropeptides and gastric mucosal homeostasis. | Current topics in medicinal chemistry 20040101 |
| Pramlintide for the treatment of insulin-requiring diabetes mellitus: rationale and review of clinical data. | Drugs 20040101 |
| Method for measuring neurotoxicity of aggregating polypeptides with the MTT assay on differentiated neuroblastoma cells. | Brain research bulletin 20031230 |
| Fibrillogenic amylin evokes islet beta-cell apoptosis through linked activation of a caspase cascade and JNK1. | The Journal of biological chemistry 20031226 |
| -To: Poa NR, Cooper GJS, Edgar PF: Amylin gene promoter mutations predispose to Type 2 diabetes in New Zealand Maori. Diabetologia 46: 574-578. | Diabetologia 20031201 |
| Effect of pramlintide on A1C and body weight in insulin-treated African Americans and Hispanics with type 2 diabetes: a pooled post hoc analysis. | Metabolism: clinical and experimental 20031201 |
| Amylin competes for binding sites of CGRP in the chamber angle and uvea of monkey, cat, and pig eye. | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20031201 |
| Ex vivo human placental transfer of the peptides pramlintide and exenatide (synthetic exendin-4). | Human & experimental toxicology 20031201 |
| Amylin gene expression mediated by cAMP/PKA and transcription factors HNF-1 and NFY. | Molecular and cellular endocrinology 20031128 |
| Pramlintide reduces postprandial glucose excursions when added to regular insulin or insulin lispro in subjects with type 1 diabetes: a dose-timing study. | Diabetes care 20031101 |
| Prevalence and clinicopathological characteristics of islet amyloid in chinese patients with type 2 diabetes. | Diabetes 20031101 |
| Addition of pramlintide to insulin therapy lowers HbA1c in conjunction with weight loss in patients with type 2 diabetes approaching glycaemic targets. | Diabetes, obesity & metabolism 20031101 |
| Involvement of calcitonin gene-related peptide in elevation of skin temperature in castrated male rats. | Urology 20031101 |
| Hepatocyte nuclear factor 1 negatively regulates amylin gene expression. | Biochemical and biophysical research communications 20031017 |
| Suppression by polycyclic compounds of the conversion of human amylin into insoluble amyloid. | The Biochemical journal 20030915 |
| Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid. | Diabetes 20030901 |
| An insulin-degrading enzyme inhibitor decreases amylin degradation, increases amylin-induced cytotoxicity, and increases amyloid formation in insulinoma cell cultures. | Diabetes 20030901 |
| [Experimental study of amylin-induced functional damage to rat pancreatic islet cells in vitro]. | Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20030901 |
| Amylin in pancreatic islets and pancreatic endocrine neoplasms. | Pathology international 20030901 |
| Beneficial effects of insulin versus sulphonylurea on insulin secretion and metabolic control in recently diagnosed type 2 diabetic patients. | Diabetes care 20030801 |
| American Diabetes Association--63rd Scientific Sessions. Clinical data. 13-17 June 2003, New Orleans, LA, USA. | IDrugs : the investigational drugs journal 20030801 |
| Mercury contamination of rat amylin mimics vasoactivity and cytotoxic effects. | Peptides 20030801 |
| Human amylin actions on rat cholinergic basal forebrain neurons: antagonism of beta-amyloid effects. | Journal of neurophysiology 20030601 |
| Phlorizin treatment prevents the decrease in plasma insulin levels but not the progressive histopathological changes in the pancreatic islets during aging of Zucker diabetic fatty rats. | Journal of endocrinological investigation 20030601 |
| Postnatally disturbed pancreatic islet cell distribution in human islet amyloid polypeptide transgenic mice. | Regulatory peptides 20030515 |
| Proteoglycans synthesized and secreted by pancreatic islet beta-cells bind amylin. | Archives of biochemistry and biophysics 20030515 |
| Differential effects of amylin and salmon calcitonin on neuropeptide gene expression in the lateral hypothalamic area and the arcuate nucleus of the rat. | Neuroscience letters 20030501 |
| S20G mutation of the amylin gene is associated with a lower body mass index in Korean type 2 diabetic patients. | Diabetes research and clinical practice 20030501 |
| Conformational preferences of the amylin nucleation site in SDS micelles: an NMR study. | Biopolymers 20030501 |
| Inverse relation between amylin and glucagon secretion in healthy and diabetic human subjects. | European journal of clinical investigation 20030401 |
| Islet amyloid polypeptide and type 2 diabetes. | Experimental gerontology 20030401 |
| Amylin gene promoter mutations predispose to Type 2 diabetes in New Zealand Maori. | Diabetologia 20030401 |
| Islet amyloid polypeptide inhibits glucagon release and exerts a dual action on insulin release from isolated islets. | Regulatory peptides 20030328 |
| Human osteoblast-like cell proliferation induced by calcitonin-related peptides involves PKC activity. | American journal of physiology. Endocrinology and metabolism 20030301 |
| Short peptide amyloid organization: stabilities and conformations of the islet amyloid peptide NFGAIL. | Biophysical journal 20030301 |
| Pramlintide as an adjunct to insulin therapy improves long-term glycemic and weight control in patients with type 2 diabetes: a 1-year randomized controlled trial. | Diabetes care 20030301 |
| Full-length rat amylin forms fibrils following substitution of single residues from human amylin. | Journal of molecular biology 20030227 |
| Increased dietary fat promotes islet amyloid formation and beta-cell secretory dysfunction in a transgenic mouse model of islet amyloid. | Diabetes 20030201 |
| Aspirin and diabetes: inhibition of amylin aggregation by nonsteroidal anti-inflammatory drugs. | Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20030201 |
| Specificity of porcine calcitonin receptor and calcitonin receptor-like receptor in the presence of receptor-activity-modifying proteins. | Hypertension research : official journal of the Japanese Society of Hypertension 20030201 |
| Calcitonin receptor isoforms expressed in the developing rat kidney. | Kidney international 20030201 |
| Amylin in human pancreatic islets. | Pathology 20030201 |
| Transcription factor occupancy of the insulin gene in vivo. Evidence for direct regulation by Nkx2.2. | The Journal of biological chemistry 20030110 |
| Investigation of CGRP receptors and peptide pharmacology in human coronary arteries. Characterization with a nonpeptide antagonist. | The Journal of pharmacology and experimental therapeutics 20030101 |
| Impact of pramlintide on glucose fluctuations and postprandial glucose, glucagon, and triglyceride excursions among patients with type 1 diabetes intensively treated with insulin pumps. | Diabetes care 20030101 |
| Pramlintide: (AC 137, AC 0137, Symlin, Tripro-Amylin). | BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 20030101 |
| Endogenous amylin contributes to the anorectic effects of cholecystokinin and bombesin. | Peptides 20030101 |
| Histamine H1 receptors in the ventromedial hypothalamus mediate the anorectic action of the pancreatic hormone amylin. | Peptides 20030101 |
| Elevated fasting plasma level of islet amyloid polypeptide (IAPP) in chronic alcoholic pancreatitis (CAP). | Hepato-gastroenterology 20030101 |
| The effect of apolipoprotein E deficiency on islet amyloid deposition in human islet amyloid polypeptide transgenic mice. | Diabetologia 20030101 |
| Central amylin signaling and the regulation of energy homeostasis. | Current pharmaceutical design 20030101 |
| For parents. Type 1 diabetes research. Balancing hope with realism. | Diabetes self-management 20030101 |
| Amylin in the periphery. | TheScientificWorldJournal 20030101 |
| Pramlintide for the treatment of diabetes mellitus. | The Annals of pharmacotherapy 20030101 |
| [Amylin--a partner hormone to insulin]. | Medicinski arhiv 20030101 |
| [New regulatory peptides in rat stomach secretion (amylin, PGP, semax)]. | Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20030101 |
| Regulation of amylin release from cultured rabbit gastric fundic mucosal cells. | BMC physiology 20030101 |
| Immunohistochemical localization of amylin in human pancreas, thyroid, pituitary and their tumors. | Acta histochemica 20030101 |
| Weight effect of current and experimental drugs for diabetes mellitus: from promotion to alleviation of obesity. | Treatments in endocrinology 20030101 |
| Effects of free fatty acid on polymerization of islet amyloid polypeptide (IAPP) in vitro and on amyloid fibril formation in cultivated isolated islets of transgenic mice overexpressing human IAPP. | Molecular medicine (Cambridge, Mass.) 20021201 |
| [Amylin--its physiological role in humans]. | Ceskoslovenska fysiologie 20021201 |
| Pathogenesis of feline diabetes mellitus. | Molecular and cellular endocrinology 20021129 |
| Increased expression and activation of c-Jun contributes to human amylin-induced apoptosis in pancreatic islet beta-cells. | Journal of molecular biology 20021122 |
| Effects of ghrelin and amylin on dopamine, norepinephrine and serotonin release in the hypothalamus. | European journal of pharmacology 20021115 |
| Amylin-induced cytotoxicity is associated with activation of caspase-3 and MAP kinases. | Biological chemistry 20021101 |
| Polymorphism in intron 2 of islet amyloid polypeptide gene is associated with lower low-density lipoprotein cholesterol in nondiabetic subjects and in type 2 diabetic patients. | Endocrine 20021101 |
| Amylin, food intake, and obesity. | Obesity research 20021001 |
| Localization of a fibrillar amyloid beta-protein binding domain on its precursor. | The Journal of biological chemistry 20020927 |
| Inhibition of amyloid fibril formation of human amylin by N-alkylated amino acid and alpha-hydroxy acid residue containing peptides. | Chemistry (Weinheim an der Bergstrasse, Germany) 20020916 |
| Oligonucleotide microarray analysis of intact human pancreatic islets: identification of glucose-responsive genes and a highly regulated TGFbeta signaling pathway. | Endocrinology 20020901 |
| Anti-diabetogenic effect of the human amylin analogue, pramlintide, in Type 1 diabetes is not mediated by GLP-1. | Diabetic medicine : a journal of the British Diabetic Association 20020901 |
| Islet amyloid, metabolic syndrome, and the natural progressive history of type 2 diabetes mellitus. | JOP : Journal of the pancreas 20020901 |
| The human amylin analog, pramlintide, reduces postprandial hyperglucagonemia in patients with type 2 diabetes mellitus. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20020901 |
| [Diagnostic use of gene polymorphism for type 2 diabetes]. | Rinsho byori. The Japanese journal of clinical pathology 20020901 |
| Amylin and glucose co-activate area postrema neurons of the rat. | Neuroscience letters 20020809 |
| Expression pattern of IAPP and prohormone convertase 1/3 reveals a distinctive set of endocrine cells in the embryonic pancreas. | Mechanisms of development 20020701 |
| Estrogen can prevent or reverse obesity and diabetes in mice expressing human islet amyloid polypeptide. | Diabetes 20020701 |
| Amylin, released from the gastric fundus, stimulates somatostatin and thus inhibits histamine and acid secretion in mice. | Gastroenterology 20020701 |
| Islet redox stress: the manifold toxicities of insulin resistance, metabolic syndrome and amylin derived islet amyloid in type 2 diabetes mellitus. | JOP : Journal of the pancreas 20020701 |
| [Secretion and metabolism of insulin]. | Nihon rinsho. Japanese journal of clinical medicine 20020701 |
| [Amylin]. | Nihon rinsho. Japanese journal of clinical medicine 20020701 |
| [Mutation of amylin (IAPP) gene]. | Nihon rinsho. Japanese journal of clinical medicine 20020701 |
| The human amylin analog, pramlintide, corrects postprandial hyperglucagonemia in patients with type 1 diabetes. | Metabolism: clinical and experimental 20020501 |
| Glucoregulatory endocrine responses to intermittent exercise of different intensities: plasma changes in a pancreatic beta-cell peptide, amylin. | Metabolism: clinical and experimental 20020501 |
| Acute 3rd-ventricular amylin infusion potently reduces food intake but does not produce aversive consequences. | Peptides 20020501 |
| Islet amyloid: phase partitioning and secondary nucleation are central to the mechanism of fibrillogenesis. | Biochemistry 20020409 |
| A randomized study and open-label extension evaluating the long-term efficacy of pramlintide as an adjunct to insulin therapy in type 1 diabetes. | Diabetes care 20020401 |
| Functional interaction of G protein-coupled receptors of the adrenomedullin peptide family with accessory receptor-activity-modifying proteins (RAMP). | Microscopy research and technique 20020401 |
| Effects of pramlintide, an amylin analogue, on gastric emptying in type 1 and 2 diabetes mellitus. | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20020401 |
| Effects of amylin and salmon calcitonin on feeding and drinking behavior in pygmy goats. | Physiology & behavior 20020401 |
| Novel peptides under development for the treatment of type 1 and type 2 diabetes mellitus. | Current drug targets. Immune, endocrine and metabolic disorders 20020401 |
| Amylin is associated with delayed gastric emptying in critically ill children. | Intensive care medicine 20020301 |
| Current and future perspective in the management of diabetes. | Journal of the Indian Medical Association 20020301 |
| Insulin and amylin release are both diminished in first-degree relatives of subjects with type 2 diabetes. | Diabetes care 20020201 |
| Transient increase of rat gastric amylin in the neonatal period and in experimental ulcers. | Journal of gastroenterology 20020101 |
| Role of amylin in insulin secretion and action in humans: antagonist studies across the spectrum of insulin sensitivity. | Diabetes/metabolism research and reviews 20020101 |
| Adjunctive therapy with the amylin analogue pramlintide leads to a combined improvement in glycemic and weight control in insulin-treated subjects with type 2 diabetes. | Diabetes technology & therapeutics 20020101 |
| Pramlintide: an agent for glycemic control plus weight control? | Diabetes technology & therapeutics 20020101 |
| Unresolved challenges with insulin therapy in type 1 and type 2 diabetes: potential benefit of replacing amylin, a second beta-cell hormone. | Diabetes technology & therapeutics 20020101 |
| Is pramlintide an adjunct to insulin therapy? | Diabetes technology & therapeutics 20020101 |
| Amylin and adrenomedullin: novel regulators of bone growth. | Current pharmaceutical design 20020101 |
| [Postpartum evaluation of amylin secretion in gestational diabetes mellitus]. | Medycyna wieku rozwojowego 20020101 |
| The specificity of amylin for the diagnosis of pancreatic adenocarcinoma. | International journal of gastrointestinal cancer 20020101 |
| Production of cAMP by adrenomedullin in human oligodendroglial cell line KG1C: comparison with calcitonin gene-related peptide and amylin. | Brain research. Molecular brain research 20011216 |
| Vasorelaxant effect of glucagon-like peptide-(7-36)amide and amylin on the pulmonary circulation of the rat. | Regulatory peptides 20011215 |
| Amylin potently activates AP neurons possibly via formation of the excitatory second messenger cGMP. | American journal of physiology. Regulatory, integrative and comparative physiology 20011201 |
| Enhanced in vitro production of amyloid-like fibrils from mutant (S20G) islet amyloid polypeptide. | Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 20011201 |
| Islet amyloid and type 2 diabetes: from molecular misfolding to islet pathophysiology. | Biochimica et biophysica acta 20011129 |
| Glucose and forskolin regulate IAPP gene expression through different signal transduction pathways. | American journal of physiology. Endocrinology and metabolism 20011101 |
| Inhibition of central amylin signaling increases food intake and body adiposity in rats. | Endocrinology 20011101 |
| Histamine H1 receptors mediate the anorectic action of the pancreatic hormone amylin. | American journal of physiology. Regulatory, integrative and comparative physiology 20011101 |
| Islet amyloid develops diffusely throughout the pancreas before becoming severe and replacing endocrine cells. | Diabetes 20011101 |
| High plasma amylin/islet amyloid polypeptide levels in patients with residual medullary thyroid carcinoma after total thyroidectomy. | European journal of endocrinology 20011101 |
| Adrenomedullin and related peptides: receptors and accessory proteins. | Peptides 20011101 |
| Pramlintide (Amylin). | Current opinion in investigational drugs (London, England : 2000) 20011101 |
| Amylin infusion into rat nucleus accumbens potently depresses motor activity and ingestive behavior. | American journal of physiology. Regulatory, integrative and comparative physiology 20011001 |
| Effect of amylin on mast cell secretion as a possible mechanism increasing gastric mucosa resistance. | Bulletin of experimental biology and medicine 20011001 |
| Effect of amylin on the tone of rat aorta ring preparation. | Bulletin of experimental biology and medicine 20011001 |
| Analysis of the minimal amyloid-forming fragment of the islet amyloid polypeptide. An experimental support for the key role of the phenylalanine residue in amyloid formation. | The Journal of biological chemistry 20010907 |
| Amylin replacement with pramlintide as an adjunct to insulin therapy in type 1 and type 2 diabetes mellitus: a physiological approach toward improved metabolic control. | Current pharmaceutical design 20010901 |
| Analysis of responses to hAmylin, hCGRP, and hADM in isolated resistance arteries from the mesenteric vascular bed of the rat. | Peptides 20010901 |
| Islet amyloid polypeptide is not a satisfactory marker for detecting pancreatic cancer. | Gastroenterology 20010901 |
| In vivo glucose-stimulated amylin secretion is increased in nondiabetic patients with pancreatic cancer. | Metabolism: clinical and experimental 20010901 |
| Amylin receptor agonists: a novel pharmacological approach in the management of insulin-treated diabetes mellitus. | Expert opinion on investigational drugs 20010901 |
| Alteration in phosphorylation of P20 is associated with insulin resistance. | Diabetes 20010801 |
| Islet amyloid polypeptide promotes beta-cell proliferation in neonatal rat pancreatic islets. | Diabetologia 20010801 |
| CGRP receptors mediating CGRP-, adrenomedullin- and amylin-induced relaxation in porcine coronary arteries. Characterization with 'Compound 1' (WO98/11128), a non-peptide antagonist. | British journal of pharmacology 20010801 |
| Effects of calcitonin, amylin, and calcitonin gene-related peptide on osteoclast development. | Bone 20010801 |
| Cloning, characterization and central nervous system distribution of receptor activity modifying proteins in the rat. | The European journal of neuroscience 20010801 |
| Distribution of amylin-immunoreactive neurons in the monkey hypothalamus and their relationships with the histaminergic system. | Archives of histology and cytology 20010801 |
| Effect of insulin, proinsulin, and amylin on renin release from perfused rat kidney. | Metabolism: clinical and experimental 20010701 |
| The anorectic effect of a chronic peripheral infusion of amylin is abolished in area postrema/nucleus of the solitary tract (AP/NTS) lesioned rats. | International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 20010701 |
| S20G mutation of the amylin gene is associated with Type II diabetes in Japanese. Study Group of Comprehensive Analysis of Genetic Factors in Diabetes Mellitus. | Diabetologia 20010701 |
| 'A' is for amylin and amyloid in type 2 diabetes mellitus. | JOP : Journal of the pancreas 20010701 |
| Effect of calcitonin gene related peptide on the adenylate cyclase activity in abalone gill membranes. | Regulatory peptides 20010615 |
| Dopamine D(2) receptors mediate amylin's acute satiety effect. | American journal of physiology. Regulatory, integrative and comparative physiology 20010601 |
| Direct inhibitory effect of adrenomedullin, calcitonin gene-related peptide, calcitonin, and amylin on cholecystokinin-induced contraction of guinea-pig isolated caecal circular smooth muscle cells. | Peptides 20010601 |
| Plasma amylin concentration is related to the severity of intestinal ischemic injury in rats. | Surgery 20010601 |
| Agouti signaling protein stimulates islet amyloid polypeptide (amylin) secretion in pancreatic beta-cells. | Experimental biology and medicine (Maywood, N.J.) 20010601 |
| The Tet-On system in transgenic mice: inhibition of the mouse pdx-1 gene activity by antisense RNA expression in pancreatic beta-cells. | Journal of molecular medicine (Berlin, Germany) 20010601 |
| Identification of a heparin binding domain in the N-terminal cleavage site of pro-islet amyloid polypeptide. Implications for islet amyloid formation. | The Journal of biological chemistry 20010518 |
| Islet amyloid polypeptide: identification of long-range contacts and local order on the fibrillogenesis pathway. | Journal of molecular biology 20010511 |
| Identification of a novel human islet amyloid polypeptide beta-sheet domain and factors influencing fibrillogenesis. | Journal of molecular biology 20010504 |
| Amylin and bone metabolism in streptozotocin-induced diabetic rats. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20010501 |
| Evidence that amylin stimulates lipolysis in vivo: a possible mediator of induced insulin resistance. | American journal of physiology. Endocrinology and metabolism 20010401 |
| High glucose concentration favors the selective secretion of islet amyloid polypeptide through a constitutive secretory pathway in human pancreatic islets. | Pancreas 20010401 |
| Familial early-onset type 2 diabetes in Chinese patients: obesity and genetics have more significant roles than autoimmunity. | Diabetes care 20010401 |
| The islet amyloid polypeptide (amylin) gene S20G mutation in Chinese subjects: evidence for associations with type 2 diabetes and cholesterol levels. | Clinical endocrinology 20010401 |
| Promotion of formation of amyloid fibrils by aluminium adenosine triphosphate (AlATP). | Journal of inorganic biochemistry 20010401 |
| Characterization of CGRP(1) receptors in the guinea pig basilar artery. | European journal of pharmacology 20010302 |
| Selective amylin inhibition of the glucagon response to arginine is extrinsic to the pancreas. | American journal of physiology. Endocrinology and metabolism 20010301 |
| Comparative effects of amylin and cholecystokinin on food intake and gastric emptying in rats. | American journal of physiology. Regulatory, integrative and comparative physiology 20010301 |
| Does neuropeptide Y contribute to the anorectic action of amylin? | Peptides 20010301 |
| beta-cell dysfunction and failure in type 2 diabetes: potential mechanisms. | Diabetes 20010201 |
| New pharmacological development (alpha glucosidase inhibitors, amylin analogues, GLP-1, thiozolidinediones, short acting insulin analogues). | The Journal of the Association of Physicians of India 20010125 |
| Early changes in islet hormone secretion in the hamster pancreatic cancer model. | Teratogenesis, carcinogenesis, and mutagenesis 20010101 |
| Synthesis and purification of amyloidogenic peptides. | Analytical biochemistry 20010101 |
| Ultrastructural evidence that apoptosis is the mechanism by which human amylin evokes death in RINm5F pancreatic islet beta-cells. | Cell biology international 20010101 |
| Quantitation in receptor pharmacology. | Receptors & channels 20010101 |
| [Pancreatic hormone amylin and integrity of the gastric mucosa]. | Vestnik Rossiiskoi akademii meditsinskikh nauk 20010101 |
| On the role of islet amyloid polypeptide in glucose intolerance and anorexia of pancreatic cancer. | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20010101 |
| Amyloidogenicity and cytotoxicity of islet amyloid polypeptide. | Biopolymers 20010101 |
| Amylin: localization, effects on cerebral arteries and on local cerebral blood flow in the cat. | TheScientificWorldJournal 20010101 |
| Renal amylin binding in normotensive and hypertensive rats: effects of angiotensin converting enzyme inhibition with perindopril. | Journal of hypertension 19971101 |
| Effect of amylin in various experimental models of gastric ulcer. | European journal of pharmacology 19970806 |
| Glucose regulation of islet amyloid polypeptide gene expression in rat pancreatic islets. | The American journal of physiology 19970401 |
| Selective inhibition of Abeta fibril formation. | The Journal of biological chemistry 19960223 |
| Effect of dexamethasone on insulin sensitivity, islet amyloid polypeptide and insulin secretion in humans. | Diabetologia 19930101 |
| Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation. | Proceedings of the National Academy of Sciences of the United States of America 19900701 |
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