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1218942-37-0 | 1H-Pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione, 2-(2-chlorophenyl)-4-[3-(dimethylamino)phenyl]-5-methyl-
CAS No: 1218942-37-0 Catalog No: AG0016BZ MDL No:MFCD27923122
Product Description
Catalog Number:
AG0016BZ
Chemical Name:
1H-Pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione, 2-(2-chlorophenyl)-4-[3-(dimethylamino)phenyl]-5-methyl-
CAS Number:
1218942-37-0
Molecular Formula:
C21H19ClN4O2
Molecular Weight:
394.8542
MDL Number:
MFCD27923122
IUPAC Name:
2-(2-chlorophenyl)-4-[3-(dimethylamino)phenyl]-5-methyl-1H-pyrazolo[4,3-c]pyridine-3,6-dione
InChI:
InChI=1S/C21H19ClN4O2/c1-24(2)14-8-6-7-13(11-14)20-19-16(12-18(27)25(20)3)23-26(21(19)28)17-10-5-4-9-15(17)22/h4-12,23H,1-3H3
InChI Key:
RGYQPQARIQKJKH-UHFFFAOYSA-N
SMILES:
Clc1ccccc1n1[nH]c2c(c1=O)c(c1cccc(c1)N(C)C)n(c(=O)c2)C
UNII:
45II35329V
Properties
Complexity:
732
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
394.12g/mol
Formal Charge:
0
Heavy Atom Count:
28
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
394.859g/mol
Monoisotopic Mass:
394.12g/mol
Rotatable Bond Count:
3
Topological Polar Surface Area:
55.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.2
Literature
| Title | Journal |
|---|---|
| Dual oxidase: a novel therapeutic target in allergic disease. | British journal of pharmacology 20180501 |
| Cholesteryl ester-transfer protein inhibitors stimulate aldosterone biosynthesis in adipocytes through Nox-dependent processes. | The Journal of pharmacology and experimental therapeutics 20150401 |
| Inhibition of NOX1/4 with GKT137831: a potential novel treatment to attenuate neuroglial cell inflammation in the retina. | Journal of neuroinflammation 20150101 |
| Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. | Hepatology (Baltimore, Md.) 20121201 |
| The Nox4 inhibitor GKT137831 attenuates hypoxia-induced pulmonary vascular cell proliferation. | American journal of respiratory cell and molecular biology 20121101 |
| Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo. | Free radical biology & medicine 20120715 |
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