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121808-62-6 | Pidotimod
CAS No: 121808-62-6 Catalog No: AG00162L MDL No:MFCD00867583
Product Description
Catalog Number:
AG00162L
Chemical Name:
Pidotimod
CAS Number:
121808-62-6
Molecular Formula:
C9H12N2O4S
Molecular Weight:
244.2676
MDL Number:
MFCD00867583
IUPAC Name:
(4R)-3-[(2S)-5-oxopyrrolidine-2-carbonyl]-1,3-thiazolidine-4-carboxylic acid
InChI:
InChI=1S/C9H12N2O4S/c12-7-2-1-5(10-7)8(13)11-4-16-3-6(11)9(14)15/h5-6H,1-4H2,(H,10,12)(H,14,15)/t5-,6-/m0/s1
InChI Key:
UUTKICFRNVKFRG-WDSKDSINSA-N
SMILES:
O=C1CC[C@H](N1)C(=O)N1CSC[C@H]1C(=O)O
UNII:
785363R681
NSC Number:
759841
Properties
Complexity:
346
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
2
Defined Bond Stereocenter Count:
0
Exact Mass:
244.052g/mol
Formal Charge:
0
Heavy Atom Count:
16
Hydrogen Bond Acceptor Count:
5
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
244.265g/mol
Monoisotopic Mass:
244.052g/mol
Rotatable Bond Count:
2
Topological Polar Surface Area:
112A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.7
Literature
| Title | Journal |
|---|---|
| Pidotimod: the state of art. | Clinical and molecular allergy : CMA 20150101 |
| Modulation of airway epithelial cell functions by Pidotimod: NF-kB cytoplasmatic expression and its nuclear translocation are associated with an increased TLR-2 expression. | Italian journal of pediatrics 20130101 |
| Quantitative determination of pidotimod in human plasma by liquid chromatography tandem mass spectrometry: application to a bioequivalence study. | Arzneimittel-Forschung 20120201 |
| Current State-of-Art and New Trends on Lipid Nanoparticles (SLN and NLC) for Oral Drug Delivery. | Journal of drug delivery 20120101 |
| Molecular mechanism of macrophage activation by red ginseng acidic polysaccharide from Korean red ginseng. | Mediators of inflammation 20120101 |
| Water-in-oil-in-water double emulsions: an excellent delivery system for improving the oral bioavailability of pidotimod in rats. | Journal of pharmaceutical sciences 20110601 |
| Self-double-emulsifying drug delivery system (SDEDDS): a new way for oral delivery of drugs with high solubility and low permeability. | International journal of pharmaceutics 20110516 |
| Complementary treatment with oral pidotimod plus vitamin C after laser vaporization for female genital warts: a prospective study. | Journal of medicine and life 20100815 |
| Hydrophilic interaction liquid chromatography-tandem mass spectrometry for the determination of adefovir in human plasma and its application to a pharmacokinetic study. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100801 |
| Pidotimod promotes functional maturation of dendritic cells and displays adjuvant properties at the nasal mucosa level. | International immunopharmacology 20091101 |
| High-performance liquid chromatography-tandem mass spectrometry for the determination of pidotimod in human plasma and its application to a pharmacokinetic study. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090815 |
| Pidotimod: a reappraisal. | International journal of immunopathology and pharmacology 20090101 |
| Synergistic immunostimulatory effect of pidotimod and red ginseng acidic polysaccharide on humoral immunity of immunosuppressed mice. | Die Pharmazie 20081201 |
| Synergistic immunostimulating activity of pidotimod and red ginseng acidic polysaccharide against cyclophosphamide-induced immunosuppression. | Archives of pharmacal research 20080901 |
| Henoch-Schönlein purpura associated with pidotimod therapy. | Clinical and experimental rheumatology 20080101 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Urinary tract infection in children. | Clinical evidence 20050601 |
| [Comparative meta-analysis of immunoestimulant agents used in pediatric patients in Mexico]. | Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) 20050101 |
| Immune modulator pidotimod decreases the in vitro expression of CD30 in peripheral blood mononuclear cells of atopic asthmatic and normal children. | The Journal of asthma : official journal of the Association for the Care of Asthma 20040101 |
| Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease. | Alternative medicine review : a journal of clinical therapeutic 20030801 |
| [Therapy with cytokines and thymic factors in a complicated case of common variable immunodeficiency]. | Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) 20030101 |
| Clinical evaluation and changes of the respiratory epithelium function after administration of Pidotimod in Greek children with recurrent respiratory tract infections. | Minerva pediatrica 20020801 |
| [Pidotimod in recurring respiratory infection in children with allergic rhinitis, asthma, or both conditions]. | Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) 20020101 |
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