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Home > Imidazoles > 1218-35-5
1218-35-5 | 1H-Imidazole, 2-[[4-(1,1-dimethylethyl)-2,6-dimethylphenyl]methyl]-4,5-dihydro-, hydrochloride (1:1)
CAS No: 1218-35-5 Catalog No: AG001626 MDL No:MFCD00238707
Product Description
Catalog Number:
AG001626
Chemical Name:
1H-Imidazole, 2-[[4-(1,1-dimethylethyl)-2,6-dimethylphenyl]methyl]-4,5-dihydro-, hydrochloride (1:1)
CAS Number:
1218-35-5
Molecular Formula:
C16H25ClN2
Molecular Weight:
280.8361
MDL Number:
MFCD00238707
IUPAC Name:
2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1H-imidazole;hydrochloride
InChI:
InChI=1S/C16H24N2.ClH/c1-11-8-13(16(3,4)5)9-12(2)14(11)10-15-17-6-7-18-15;/h8-9H,6-7,10H2,1-5H3,(H,17,18);1H
InChI Key:
YGWFCQYETHJKNX-UHFFFAOYSA-N
SMILES:
Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C.Cl
EC Number:
214-936-4
UNII:
X5S84033NZ
NSC Number:
757378
Properties
Complexity:
302
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
280.171g/mol
Formal Charge:
0
Heavy Atom Count:
19
Hydrogen Bond Acceptor Count:
1
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
280.84g/mol
Monoisotopic Mass:
280.171g/mol
Rotatable Bond Count:
3
Topological Polar Surface Area:
24.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| The role of rhinomanometry after nasal decongestant test in the assessment of adenoid hypertrophy in children. | International journal of pediatric otorhinolaryngology 20120301 |
| Hypertensive crisis and end-organ damage induced by over-the-counter nasal decongestant abuse. | European heart journal 20111201 |
| ['Of snakes and crocodiles': central side effects of nose drops and facts about rhinitis medicamentosa]. | Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege 20111001 |
| Rosacea (erythematotelangiectatic type) effectively improved by topical xylometazoline. | The Journal of dermatology 20110501 |
| Can we always trust rhinomanometry? | Rhinology 20110301 |
| Paradoxical increase in nasal airway resistance following a topical nasal decongestant spray. | Rhinology 20110301 |
| Xylometazoline pretreatment reduces nasotracheal intubation-related epistaxis in paediatric dental surgery. | British journal of anaesthesia 20110201 |
| A comparative analysis of the decongestive effect of oxymetazoline and xylometazoline in healthy subjects. | European journal of clinical pharmacology 20110101 |
| Xylometazoline abuse induced ischemic stroke in a young adult. | The neurologist 20110101 |
| Nasal inspiratory flow: at rest and sniffing. | International forum of allergy & rhinology 20110101 |
| Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline. | Fundamental & clinical pharmacology 20101201 |
| Case report: unilateral mydriasis following nasal cautery. | Orbit (Amsterdam, Netherlands) 20101201 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| Xylometazoline pretreatment reduces nasotracheal intubation-related epistaxis in paediatric dental surgery. | British journal of anaesthesia 20101001 |
| Prognostic value of anterior rhinomanometry in diode laser turbinoplasty. | Archives of otolaryngology--head & neck surgery 20101001 |
| A randomized trial of topical anesthesia comparing lidocaine versus lidocaine plus xylometazoline for unsedated transnasal upper gastrointestinal endoscopy. | Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20100501 |
| Effects of intranasal xylometazoline, alone or in combination with ipratropium, in patients with common cold. | Current medical research and opinion 20100401 |
| Influence of intranasal sterile isotonic sea water applications on xylometazoline administration: an experimental study in pigs. | Auris, nasus, larynx 20100201 |
| Comments on: Central serous chorioretinopathy after dacryocystorhinostomy operation on the same side. | Indian journal of ophthalmology 20100101 |
| OTC use of a topical nasal spray solution containing xylometazoline plus ipratropium in patients with common cold. | International journal of clinical pharmacology and therapeutics 20091201 |
| Effects of topical drops and sprays on mucociliary transport time and nasal air flow. | Acta oto-laryngologica 20091101 |
| Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
| A comparison of xylometazoline (Otrivine) and phenylephrine/lignocaine mixture (Cophenylcaine) for the purposes of rigid nasendoscopy: a prospective, double-blind, randomised trial. | The Journal of laryngology and otology 20090601 |
| Relation of nasal air flow to nasal cavity dimensions. | Archives of otolaryngology--head & neck surgery 20090601 |
| Efficacy and safety of intranasal xylometazoline and ipratropium in patients with common cold. | Expert opinion on pharmacotherapy 20090401 |
| Xylometazoline hydrochloride 0.1 per cent versus physiological saline in nasal surgical aftercare: a randomised, single-blinded, comparative clinical trial. | The Journal of laryngology and otology 20090101 |
| Central serous chorioretinopathy after dacryocystorhinostomy operation on the same side. | Indian journal of ophthalmology 20090101 |
| [Misuse of substances theoretically without abuse potential--case series]. | Przeglad lekarski 20090101 |
| Does nasal decongestion improve obstructive sleep apnea? | Journal of sleep research 20081201 |
| Misuse of xylometazoline nasal drops by inhalation. | Substance use & misuse 20081201 |
| The value of herbal medicines in the treatment of acute non-purulent rhinosinusitis. Results of a double-blind, randomised, controlled trial. | European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20081101 |
| [The influence of different alpha-sympathomimetic drugs and benzalkoniumchlorid on the ciliary beat frequency of in vitro cultured human nasal mucosa cells]. | Laryngo- rhino- otologie 20080101 |
| The nasal decongestant effect of xylometazoline in the common cold. | American journal of rhinology 20080101 |
| Trapping of adrenergic decongestant drugs into cellular endomembrane compartments: toxicological and pharmacological consequences. | International immunopharmacology 20071220 |
| Negative pressure pulmonary oedema. | European journal of anaesthesiology 20071201 |
| Effects of an external nasal dilator strip (ENDS) compared to xylometazolin nasal spray. | European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20071101 |
| Optical rhinometry: application on children and adolescents for nasal provocation tests. | Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20070801 |
| Efficacy and safety of topical combinations of ipratropium and xylometazoline for the treatment of symptoms of runny nose and nasal congestion associated with acute upper respiratory tract infection. | American journal of rhinology 20070101 |
| A case series of xylometazoline overdose in children. | Clinical toxicology (Philadelphia, Pa.) 20070101 |
| Effects on nasal nitric oxide production of 2 mechanisms of vasoconstriction. | Journal of investigational allergology & clinical immunology 20070101 |
| [Ultrastructural changes in human nasal mucosa in rhinitis medicamentosa]. | HNO 20061001 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Radiofrequency for inferior turbinate hypertrophy: could its long-term effect be predicted with a preoperative topical vasoconstrictor drop test? | American journal of rhinology 20060101 |
| [Pharmacological and clinical evalutation of nasal obstruction: application to xylometazoline]. | Therapie 20060101 |
| Decongestant effects of nasal xylometazoline and mometasone furoate in persistent allergic rhinitis. | Rhinology 20051201 |
| The value of Ems Mineral Salts in the treatment of rhinosinusitis in children. Prospective study on the efficacy of mineral salts versus xylometazoline in the topical nasal treatment of children. | International journal of pediatric otorhinolaryngology 20051001 |
| Comparison of decongestive capacity of xylometazoline and pseudoephedrine with rhinomanometry and MRI. | Rhinology 20050901 |
| [Treatment of inflammatory diseases of the upper respiratory tract -- comparison of a homeopathic complex remedy with xylometazoline]. | Forschende Komplementarmedizin und klassische Naturheilkunde = Research in complementary and natural classical medicine 20050201 |
| Immediate effect of benzalkonium chloride in decongestant nasal spray on the human nasal mucosal temperature. | Clinical otolaryngology and allied sciences 20040801 |
| Evaluation of protective and therapeutic effects of dexpanthenol on nasal decongestants and preservatives: results of cytotoxic studies in vitro. | American journal of rhinology 20040101 |
| The cavernous body of the human efferent tear ducts contributes to regulation of tear outflow. | Investigative ophthalmology & visual science 20031101 |
| [The tolerability of nasal drugs with special regard to preservatives and physico-chemical parameters]. | Laryngo- rhino- otologie 20031101 |
| [Tolerance and effectiveness of oxymetazoline and xylometazoline in treatment of acute rhinitis]. | HNO 20031001 |
| [Advance in therapy of acute rhinitis--comparison of efficacy and safety of xylometazoline in combination xylometazoline-dexpanthenol in patients with acute rhinitis]. | Laryngo- rhino- otologie 20030401 |
| [The protective effect of dexpanthenol in nasal sprays. First results of cytotoxic and ciliary-toxic studies in vitro]. | Laryngo- rhino- otologie 20030301 |
| No effect of a nasal decongestant on eustachian tube function in children with ventilation tubes. | The Laryngoscope 20020601 |
| High-performance liquid chromatographic method for the assay of dexamethasone and xylometazoline in nasal drops containing methyl p-hydroxybenzoate. | Journal of chromatography. A 20020308 |
| Nasal mucociliary transport: new evidence for a key role of ciliary beat frequency. | The Laryngoscope 20020301 |
| Comparison of the clinical efficacy of standard and mucoadhesive-based nasal decongestants. | British journal of clinical pharmacology 20020101 |
| Decongestant activity of a new formulation of xylometazoline nasal spray: a double-blind, randomized versus placebo and reference drugs controlled, dose-effect study. | Drugs under experimental and clinical research 20020101 |
| The effect of topical xylometazoline on the mucosal temperature of the nasal septum. | American journal of rhinology 20020101 |
| Comparison of cefuroxime with or without intranasal fluticasone for the treatment of rhinosinusitis. The CAFFS Trial: a randomized controlled trial. | JAMA 20011226 |
| Efficacy and safety of an oral formulation of cetirizine and prolonged-release pseudoephedrine versus xylometazoline nasal spray in nasal congestion. | Arzneimittel-Forschung 20011101 |
| Detection of particles within the nasal airways before and after nasal decongestion. | Clinical otolaryngology and allied sciences 20010801 |
| The effect of intranasal budesonide spray on mucosal blood flow measured with laser Doppler flowmetry. | Rhinology 20010301 |
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