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1218-34-4

1218-34-4 | L-Tryptophan, N-acetyl-

CAS No: 1218-34-4 Catalog No: AG001627 MDL No:MFCD00065976

Product Description

Catalog Number:
AG001627
Chemical Name:
L-Tryptophan, N-acetyl-
CAS Number:
1218-34-4
Molecular Formula:
C13H14N2O3
Molecular Weight:
246.2619
MDL Number:
MFCD00065976
IUPAC Name:
(2S)-2-acetamido-3-(1H-indol-3-yl)propanoic acid
InChI:
InChI=1S/C13H14N2O3/c1-8(16)15-12(13(17)18)6-9-7-14-11-5-3-2-4-10(9)11/h2-5,7,12,14H,6H2,1H3,(H,15,16)(H,17,18)/t12-/m0/s1
InChI Key:
DZTHIGRZJZPRDV-LBPRGKRZSA-N
SMILES:
CC(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2
EC Number:
214-935-9
UNII:
U9264T8OAE

Properties

Complexity:
332  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0
Exact Mass:
246.1g/mol
Formal Charge:
0
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
246.266g/mol
Monoisotopic Mass:
246.1g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
82.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.1  

Literature

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Tachykinin NK₁ receptor antagonist co-administration attenuates opioid withdrawal-mediated spinal microglia and astrocyte activation. European journal of pharmacology 20120605
Treatment with a substance P receptor antagonist is neuroprotective in the intrastriatal 6-hydroxydopamine model of early Parkinson's disease. PloS one 20120101
Conjugation of organoruthenium(II) 3-(1H-benzimidazol-2-yl)pyrazolo[3,4-b]pyridines and indolo[3,2-d]benzazepines to recombinant human serum albumin: a strategy to enhance cytotoxicity in cancer cells. Inorganic chemistry 20111219
Concerted electron-proton transfer (EPT) in the oxidation of tryptophan with hydroxide as a base. Journal of the American Chemical Society 20111214
Characterization of N-acetyltryptophan degradation products in concentrated human serum albumin solutions and development of an automated high performance liquid chromatography-mass spectrometry method for their quantitation. Journal of chromatography. A 20111014
A substance P antagonist improves outcome when administered 4 h after onset of ischaemic stroke. Brain research 20110601
Industrial stabilizers caprylate and N-acetyltryptophanate reduce the efficacy of albumin in liver patients. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20110601
Characterizing the role of the neuropeptide substance P in experimental subarachnoid hemorrhage. Brain research 20110510
Involvement of substance P in peripheral neuropathy induced by paclitaxel but not oxaliplatin. The Journal of pharmacology and experimental therapeutics 20110401
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A substance P antagonist reduces axonal injury and improves neurologic outcome when administered up to 12 hours after traumatic brain injury. Journal of neurotrauma 20110201
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Chemical constituents of a marine-derived endophytic fungus Penicillium commune G2M. Molecules (Basel, Switzerland) 20100504
Infusions of albumin increase free fraction of naproxen in healthy volunteers: a randomized crossover study. Acta anaesthesiologica Scandinavica 20100401
Changes of protein solutions during storage: a study of albumin pharmaceutical preparations. Biotechnology and applied biochemistry 20100305
Contractile responses induced by physalaemin, an analogue of substance P, in the rat esophagus. European journal of pharmacology 20100225
Transport of benzo[alpha]pyrene in the dually perfused human placenta perfusion model: effect of albumin in the perfusion medium. Basic & clinical pharmacology & toxicology 20090901
Capillary electrophoresis with indirect UV detection for the determination of stabilizers and citrates present in human albumin solutions. Journal of pharmaceutical and biomedical analysis 20090815
Substance P is associated with the development of brain edema and functional deficits after traumatic brain injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20090801
Annotating enzymes of uncertain function: the deacylation of D-amino acids by members of the amidohydrolase superfamily. Biochemistry 20090714
Effects of uric acid on nitrosation of N-acetylcysteine by diethylamine NONOate and N-acetyl-N-nitrosotryptophan. Chemical & pharmaceutical bulletin 20090701
New tryptophanase inhibitors: towards prevention of bacterial biofilm formation. Journal of enzyme inhibition and medicinal chemistry 20090401
Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor. Nature chemical biology 20090101
Tryptophan and kynurenine levels in lenses of Wistar and accelerated-senescence OXYS rats. Molecular vision 20090101
Effects of nucleobase metalation on frontier molecular orbitals: potential implications for pi-stacking interactions with tryptophan. Inorganic chemistry 20081117
Kinetics of enzyme attack on substrates covalently attached to solid surfaces: influence of spacer chain length, immobilized substrate surface concentration and surface charge. Langmuir : the ACS journal of surfaces and colloids 20081021
Quantitative determination of singlet oxygen generated by excited state aromatic amino acids, proteins, and immunoglobulins. Journal of the American Chemical Society 20080604
Two L-amino acid oxidase isoenzymes from Russell's viper (Daboia russelli russelli) venom with different mechanisms of inhibition by substrate analogs. The FEBS journal 20080501
Electron transfer between guanosine radicals and amino acids in aqueous solution. II. Reduction of guanosine radicals by tryptophan. The journal of physical chemistry. B 20080306
Electron transfer from aromatic amino acids to triplet quinones. Journal of photochemistry and photobiology. B, Biology 20070925
15N-CIDNP investigations during tryptophan, N-acetyl-L-tryptophan, and melatonin nitration with reactive nitrogen species. Free radical research 20070501
The role of N-acetyl-methioninate as a new stabilizer for albumin products. International journal of pharmaceutics 20070201
Nitrosation of N-terminally blocked tryptophan and tryptophan-containing peptides by peroxynitrite. Chembiochem : a European journal of chemical biology 20070122
On the mechanism of the ascorbic acid-induced release of nitric oxide from N-nitrosated tryptophan derivatives: scavenging of NO by ascorbyl radicals. Chemistry (Weinheim an der Bergstrasse, Germany) 20061124
Preparation and identification of anti-melatonin monoclonal antibodies. Journal of pineal research 20060501
Covalent and noncovalent interactions for [metal(dien)nucleobase](2+) complexes with L-tryptophan derivatives: formation of palladium-tryptophan species by nucleobase substitution under biologically relevant conditions. Inorganic chemistry 20060220
Catecholamine-induced release of nitric oxide from N-nitrosotryptophan derivatives: a non-enzymatic method for catecholamine oxidation. Organic & biomolecular chemistry 20060121
N-Nitroso products from the reaction of indoles with Angeli's salt. Chemical research in toxicology 20060101
Substance P promotes sleep in the ventrolateral preoptic area of rats. Brain research 20041203
Stabilizing mechanisms in commercial albumin preparations: octanoate and N-acetyl-L-tryptophanate protect human serum albumin against heat and oxidative stress. Biochimica et biophysica acta 20041001
A substance P antagonist increases brain intracellular free magnesium concentration after diffuse traumatic brain injury in rats. Journal of the American College of Nutrition 20041001
Degradation of N-acetyl tryptophan by low-energy (<12 eV) electrons. Journal of the American Chemical Society 20040929
Nitration and nitrosation of N-acetyl-L-tryptophan and tryptophan residues in proteins by various reactive nitrogen species. Free radical biology & medicine 20040901
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Synthesis and characterization of carboxymethylated cyclosophoraose, and its inclusion complexation behavior. Carbohydrate research 20040225
A mass spectrometric and molecular orbital study of H2O loss from protonated tryptophan and oxidized tryptophan derivatives. Rapid communications in mass spectrometry : RCM 20040101
More chemistry of the thaxtomin phytotoxins. Phytochemistry 20031101
PAR-2 modulates pepsinogen secretion from gastric-isolated chief cells. American journal of physiology. Gastrointestinal and liver physiology 20030901
Interpretation of fluorescence decays using a power-like model. Biophysical journal 20030701
Comparative studies on the properties of the extrinsic manganese-stabilizing protein from higher plants and of a synthetic peptide of its C-terminus. Biochimica et biophysica acta 20030605
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Effects of antidepressants in rats trained to discriminate centrally administered isoproterenol. The Journal of pharmacology and experimental therapeutics 20020801
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Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. The Journal of biological chemistry 20010518
Intra and intermolecular charge effects on the reaction of the superoxide radical anion with semi-oxidized tryptophan in peptides and N-acetyl tryptophan. Free radical research 19981101

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