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1206799-15-6 | N-[3-Fluoro-4-[[1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl]oxy]phenyl]-1-(4-fluorophenyl)-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarboxamide
CAS No: 1206799-15-6 Catalog No: AG003AMN MDL No:MFCD23160048
Product Description
Catalog Number:
AG003AMN
Chemical Name:
N-[3-Fluoro-4-[[1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl]oxy]phenyl]-1-(4-fluorophenyl)-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarboxamide
CAS Number:
1206799-15-6
Molecular Formula:
C30H22F2N6O3
Molecular Weight:
552.5309
MDL Number:
MFCD23160048
IUPAC Name:
N-[3-fluoro-4-[1-methyl-6-(1H-pyrazol-4-yl)indazol-5-yl]oxyphenyl]-1-(4-fluorophenyl)-6-methyl-2-oxopyridine-3-carboxamide
InChI:
InChI=1S/C30H22F2N6O3/c1-17-3-9-23(30(40)38(17)22-7-4-20(31)5-8-22)29(39)36-21-6-10-27(25(32)12-21)41-28-11-18-16-35-37(2)26(18)13-24(28)19-14-33-34-15-19/h3-16H,1-2H3,(H,33,34)(H,36,39)
InChI Key:
QHADVLVFMKEIIP-UHFFFAOYSA-N
SMILES:
Fc1ccc(cc1)n1c(C)ccc(c1=O)C(=O)Nc1ccc(c(c1)F)Oc1cc2cnn(c2cc1c1c[nH]nc1)C
UNII:
5OGS5K699E
Properties
Complexity:
1050
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
552.172g/mol
Formal Charge:
0
Heavy Atom Count:
41
Hydrogen Bond Acceptor Count:
7
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
552.542g/mol
Monoisotopic Mass:
552.172g/mol
Rotatable Bond Count:
6
Topological Polar Surface Area:
105A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.7
Literature
| Title | Journal |
|---|---|
| TAM receptor tyrosine kinases as emerging targets of innate immune checkpoint blockade for cancer therapy. | Immunological reviews 20170301 |
| Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation. | Nature immunology 20150801 |
| LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models. | Investigational new drugs 20130801 |
| Inhibition of ron kinase blocks conversion of micrometastases to overt metastases by boosting antitumor immunity. | Cancer discovery 20130701 |
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