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120166-69-0 | 4(1H)-Quinazolinone, 3-[2-[4-[bis(4-fluorophenyl)methylene]-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-
CAS No: 120166-69-0 Catalog No: AG000QGF MDL No:
Product Description
Catalog Number:
AG000QGF
Chemical Name:
4(1H)-Quinazolinone, 3-[2-[4-[bis(4-fluorophenyl)methylene]-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-
CAS Number:
120166-69-0
Molecular Formula:
C28H25F2N3OS
Molecular Weight:
489.5794
IUPAC Name:
3-[2-[4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl]ethyl]-2-sulfanylidene-1H-quinazolin-4-one
InChI:
InChI=1S/C28H25F2N3OS/c29-22-9-5-19(6-10-22)26(20-7-11-23(30)12-8-20)21-13-15-32(16-14-21)17-18-33-27(34)24-3-1-2-4-25(24)31-28(33)35/h1-12H,13-18H2,(H,31,35)
InChI Key:
ZCNBZFRECRPCKU-UHFFFAOYSA-N
SMILES:
Fc1ccc(cc1)C(=C1CCN(CC1)CCn1c(=S)[nH]c2c(c1=O)cccc2)c1ccc(cc1)F
Properties
Complexity:
770
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
489.169g/mol
Formal Charge:
0
Heavy Atom Count:
35
Hydrogen Bond Acceptor Count:
5
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
489.585g/mol
Monoisotopic Mass:
489.169g/mol
Rotatable Bond Count:
5
Topological Polar Surface Area:
67.7A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
5.6
Literature
| Title | Journal |
|---|---|
| A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery. | The Biochemical journal 20130415 |
| Hypoxic preconditioning induces stroke tolerance in mice via a cascading HIF, sphingosine kinase, and CCL2 signaling pathway. | Journal of neurochemistry 20121201 |
| Involvement of diacylglycerol kinase γ in modulation of iNOS synthesis in Golgi apparatus of vascular endothelial cells. | Naunyn-Schmiedeberg's archives of pharmacology 20120801 |
| Inhibition of thrombin-induced Ca²⁺ influx in platelets by R59949, an inhibitor of diacylglycerol kinase. | The Journal of pharmacy and pharmacology 20120601 |
| Reactive oxygen species stimulate insulin secretion in rat pancreatic islets: studies using mono-oleoyl-glycerol. | PloS one 20120101 |
| Diacylglycerol kinase α mediates 17-β-estradiol-induced proliferation, motility, and anchorage-independent growth of Hec-1A endometrial cancer cell line through the G protein-coupled estrogen receptor GPR30. | Cellular signalling 20111201 |
| Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. | Nature biotechnology 20111101 |
| Neuroprotection against cobalt chloride-induced cell apoptosis of primary cultured cortical neurons by salidroside. | Molecular and cellular biochemistry 20110801 |
| Diacylglycerol regulates acute hypoxic pulmonary vasoconstriction via TRPC6. | Respiratory research 20110101 |
| Role of phospholipase D2/phosphatidic acid signal transduction in micro- and delta-opioid receptor endocytosis. | Molecular pharmacology 20100701 |
| Negative regulation of diacylglycerol kinase theta mediates adenosine-dependent hepatocyte preconditioning. | Cell death and differentiation 20100601 |
| Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
| Insulin action on polyunsaturated phosphatidic acid formation in rat brain: an 'in vitro' model with synaptic endings from cerebral cortex and hippocampus. | Neurochemical research 20090701 |
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. | Proceedings of the National Academy of Sciences of the United States of America 20071218 |
| A novel role of hypoxia-inducible factor in cobalt chloride- and hypoxia-mediated expression of IL-8 chemokine in human endothelial cells. | Journal of immunology (Baltimore, Md. : 1950) 20061115 |
| Activation of HIF-prolyl hydroxylases by R59949, an inhibitor of the diacylglycerol kinase. | The Journal of biological chemistry 20050624 |
| Angiotensin II-induced Akt activation through the epidermal growth factor receptor in vascular smooth muscle cells is mediated by phospholipid metabolites derived by activation of phospholipase D. | The Journal of pharmacology and experimental therapeutics 20050301 |
| Diacylglycerol kinase gamma serves as an upstream suppressor of Rac1 and lamellipodium formation. | The Journal of biological chemistry 20040702 |
| Phospholipid mediators and MgATPase modulation causes changes in the cardiovascular effects of vasopressin in lithium carbonate-induced polyuric rats. | Methods and findings in experimental and clinical pharmacology 20040501 |
| Signaling pathways for arsenic-stimulated vascular endothelial growth factor-a expression in primary vascular smooth muscle cells. | Chemical research in toxicology 20040401 |
| Monocytic activation of protein tyrosine kinase, protein kinase A and protein kinase C induced by porins isolated from Salmonella enterica serovar Typhimurium. | The Journal of infection 20030201 |
| Phosphatidylcholine-derived phosphatidic acid and diacylglycerol are involved in the signaling pathways activated by docetaxel. | Journal of experimental therapeutics & oncology 20030101 |
| Effect of novel modulators of protein kinase C activity upon chemotherapy-induced differentiation and apoptosis in myeloid leukemic cells. | Anti-cancer drugs 20020801 |
| Diacylglycerol kinase alpha activity promotes survival of CD4+ 8+ double positive cells during thymocyte development. | Immunology 20020401 |
| Fatty acids inhibit growth-factor-induced diacylglycerol kinase alpha activation in vascular smooth-muscle cells. | The Biochemical journal 20010701 |
| Phosphatidic acid and diacylglycerol directly activate NADPH oxidase by interacting with enzyme components. | The Journal of biological chemistry 20010202 |
| Selectivity of the diacylglycerol kinase inhibitor 3-[2-(4-[bis-(4-fluorophenyl)methylene]-1-piperidinyl)ethyl]-2, 3-dihydro-2-thioxo-4(1H)quinazolinone (R59949) among diacylglycerol kinase subtypes. | Biochemical pharmacology 20000401 |
| The role of endogenously formed diacylglycerol in the propagation and termination of platelet activation. A biochemical and functional analysis using the novel diacylglycerol kinase inhibitor, R 59 949. | The Journal of biological chemistry 19890225 |
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