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1197-17-7

1197-17-7 | Cyclohexanecarboxylic acid, 4-(aminomethyl)-, cis-

CAS No: 1197-17-7 Catalog No: AG000PH0 MDL No:MFCD00001466

Product Description

Catalog Number:
AG000PH0
Chemical Name:
Cyclohexanecarboxylic acid, 4-(aminomethyl)-, cis-
CAS Number:
1197-17-7
Molecular Formula:
C8H15NO2
Molecular Weight:
157.2102
MDL Number:
MFCD00001466
IUPAC Name:
4-(aminomethyl)cyclohexane-1-carboxylic acid
InChI:
InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)
InChI Key:
GYDJEQRTZSCIOI-UHFFFAOYSA-N
SMILES:
NC[C@@H]1CC[C@@H](CC1)C(=O)O
EC Number:
214-818-2

Properties

Complexity:
139  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
157.11g/mol
Formal Charge:
0
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
157.213g/mol
Monoisotopic Mass:
157.11g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
63.3A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-2  

Literature

Title Journal
The antifibrinolytic drug tranexamic acid reduces liver injury and fibrosis in a mouse model of chronic bile duct injury. The Journal of pharmacology and experimental therapeutics 20140601
Discovery of the Fibrinolysis Inhibitor AZD6564, Acting via Interference of a Protein-Protein Interaction. ACS medicinal chemistry letters 20140508
The association between tranexamic acid and convulsive seizures after cardiac surgery: a multivariate analysis in 11 529 patients. Anaesthesia 20140201
Tranexamic acid overdosage-induced generalized seizure in renal failure. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia 20140101
Icatibant for the treatment of hereditary angioedema. The Annals of pharmacotherapy 20130101
In vivo effect of proton-pump inhibitors on gastric plasmin-dependent fibrinolysis: a study in a porcine model. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20121201
Computationally designed β-turn foldamers of γ-peptides based on 2-(aminomethyl)cyclohexanecarboxylic acid. Biopolymers 20121201
Efficacy of tranexamic acid in paediatric cardiac surgery: a systematic review and meta-analysis. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20121101
[Local use of tranexamic acid in ENT surgery]. HNO 20121101
Antifibrinolytic agents reduce blood loss during pediatric vertebral column resection procedures. Spine 20121101
A systematic review of the use of antifibrinolytic agents in pediatric surgery and implications for craniofacial use. Pediatric surgery international 20121101
Tranexamic acid-bevacizumab synergy in HHT patients presenting pulmonary arteriovenous malformations. Medical hypotheses 20121101
[Effect of Gorei-san with tranexamic acid for preventing recurrence of chronic subdural hematoma]. No shinkei geka. Neurological surgery 20121101
[Pharmacological reduction of bleeding during hip endoprosthetic replacement]. Orvosi hetilap 20121014
[Treatment alternatives in massive hemorrhage]. Medicina intensiva 20121001
Tranexamic acid in adenotonsillectomy in children: a double-blind randomized clinical trial. International journal of pediatric otorhinolaryngology 20121001
Massive transfusion: an overview of the main characteristics and potential risks associated with substances used for correction of a coagulopathy. Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 20121001
Does the intraoperative tranexamic acid decrease operative blood loss during posterior spinal fusion for treatment of adolescent idiopathic scoliosis? Spine 20121001
Tranexamic acid therapy in pediatric cardiac surgery: a single-center study. The Annals of thoracic surgery 20121001
Improving outcome in severe trauma: what's new in ABC? Imaging, bleeding and brain injury. Postgraduate medical journal 20121001
Postpartum hemorrhage management in 2012: predicting the future. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20121001
The effect of tranexamic acid on blood loss and use of blood products in total knee arthroplasty: a meta-analysis. Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA 20120901
Most effective regimen of tranexamic acid in knee arthroplasty: a prospective randomized controlled study in 240 patients. Clinical orthopaedics and related research 20120901
Efficacy of tranexamic acid on blood loss after primary cementless total hip replacement with rivaroxaban thromboprophylaxis: A case-control study in 70 patients. Orthopaedics & traumatology, surgery & research : OTSR 20120901
Perioperative treatment algorithm for bleeding burn patients reduces allogeneic blood product requirements. British journal of anaesthesia 20120901
Management of heavy menstrual bleeding in general practice. Current medical research and opinion 20120901
Tranexamic acid reduces blood loss and financial cost in primary total hip and knee replacement surgery. Orthopaedics & traumatology, surgery & research : OTSR 20120901
Rotational thromboelastometry analysis and management of life-threatening haemorrhage in isolated craniofacial injury. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20120901
Tranexamic acid effects in trauma patients with significant hemorrhage. Journal of the American College of Surgeons 20120901
BET 1: should tranexamic acid be given to patients who are having an upper gastrointestinal bleed? Emergency medicine journal : EMJ 20120901
Tranexamic acid (TXA) use in trauma. Journal of emergency nursing: JEN : official publication of the Emergency Department Nurses Association 20120901
Daily menstrual blood loss and quality of life in women with heavy menstrual bleeding. Women's health (London, England) 20120901
[Therapy of trauma-induced coagulopathy - what is the evidence?]. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20120901
Reducing blood loss in primary knee arthroplasty: a prospective randomised controlled trial of tranexamic acid and fibrin spray. The Knee 20120801
Tranexamic acid reduces blood loss after off-pump coronary surgery: a prospective, randomized, double-blind, placebo-controlled study. Anesthesia and analgesia 20120801
Treatment of intracerebral hemorrhage with tranexamic acid after thrombolysis with tissue plasminogen activator. Neurocritical care 20120801
Treatment of melasma with oral administration of tranexamic acid. Aesthetic plastic surgery 20120801
Tranexamic acid for routine use in off-pump coronary artery bypass surgery: evidence base 'fait accompli' or more research needed? Anesthesia and analgesia 20120801
[Coagulation management of trauma patients with unstabile circulation : establishment of a hemoglobin-oriented standard operating procedure]. Der Anaesthesist 20120801
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[Diagnosis of mild hemophilia A made by massive intraabdominal bleeding in a 13-year-old boy]. [Rinsho ketsueki] The Japanese journal of clinical hematology 20120801
Effectiveness and safety of tranexamic acid in reducing blood loss in total knee arthroplasty: a meta-analysis. The Journal of bone and joint surgery. American volume 20120703
Combined treatment with APCC (FEIBA®) and tranexamic acid in patients with haemophilia A with inhibitors and in patients with acquired haemophilia A--a two-centre experience. Haemophilia : the official journal of the World Federation of Hemophilia 20120701
Tranexamic acid increases hemoglobin and ferritin levels in women with heavy menstrual bleeding. Journal of women's health (2002) 20120701
Comparative evaluation of the effects of tranexamic acid and low-dose aprotinin on post-valvular heart surgery bleeding and allogenic transfusion. Interactive cardiovascular and thoracic surgery 20120701
Patient blood management in Europe. British journal of anaesthesia 20120701
Treatment of inherited platelet disorders. Haemophilia : the official journal of the World Federation of Hemophilia 20120701
The blood-saving effect of tranexamic acid in minimally invasive total knee replacement: is an additional pre-operative injection effective? The Journal of bone and joint surgery. British volume 20120701
Obstetric hemorrhage and coagulation: an update. Thromboelastography, thromboelastometry, and conventional coagulation tests in the diagnosis and prediction of postpartum hemorrhage. Obstetrical & gynecological survey 20120701
Factor XIII and tranexamic acid but not recombinant factor VIIa attenuate tissue plasminogen activator-induced hyperfibrinolysis in human whole blood. Anesthesia and analgesia 20120601
Evaluation of the efficacy of tranexamic acid on blood loss in orthognathic surgery. A prospective, randomized clinical study. International journal of oral and maxillofacial surgery 20120601
Comparison of aprotinin and tranexamic acid in adult scoliosis correction surgery. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 20120601
Should antifibrinolytics be given in all patients with trauma? Current opinion in anaesthesiology 20120601
Topical 5% tranexamic acid for the treatment of melasma in Asians: a double-blind randomized controlled clinical trial. Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology 20120601
Fibrin(ogen)-independent role of plasminogen activators in acetaminophen-induced liver injury. The American journal of pathology 20120601
Management of a dentigerous cyst in a medically compromised geriatric patient: a case report. Gerodontology 20120601
The inhibiting effect of factor XIII on hyperfibrinolysis. Anesthesia and analgesia 20120601
New horizons in treating disorders of hyperpigmentation in skin of color. Seminars in cutaneous medicine and surgery 20120601
Massive transfusion: an evidence-based review of recent developments. Archives of surgery (Chicago, Ill. : 1960) 20120601
Pharmacokinetic studies in women of 2 novel oral formulations of tranexamic acid therapy for heavy menstrual bleeding. American journal of therapeutics 20120501
A phase 2 prospective, randomized, double-blind trial comparing the effects of tranexamic acid with ecallantide on blood loss from high-risk cardiac surgery with cardiopulmonary bypass (CONSERV-2 Trial). The Journal of thoracic and cardiovascular surgery 20120501
Use of tranexamic acid to reduce bleeding in burns surgery. Journal of plastic, reconstructive & aesthetic surgery : JPRAS 20120501
Differential effects of aprotinin and tranexamic acid on outcomes and cytokine profiles in neonates undergoing cardiac surgery. The Journal of thoracic and cardiovascular surgery 20120501
Efficacy of tranexamic acid in the treatment of idiopathic and non-functional heavy menstrual bleeding: a systematic review. Acta obstetricia et gynecologica Scandinavica 20120501
The first probable case of hereditary angioedema in Vietnam. Allergy, asthma & immunology research 20120501
Trends in the surgical options for the treatment of menorrhagia in Scotland: examination of health episode statistics, 2000-2008. Scottish medical journal 20120501
Plasma transfusion for patients with severe hemorrhage: what is the evidence? Transfusion 20120501
Are antifibrinolytics helpful in decreasing blood loss and transfusions during spinal fusion surgery in children with cerebral palsy scoliosis? Spine 20120420
Antifibrinolytic therapy to reduce haemoptysis from any cause. The Cochrane database of systematic reviews 20120418
Tranexamic acid reduces blood transfusions in elderly patients undergoing combined aortic valve and coronary artery bypass graft surgery: a randomized controlled trial. Journal of cardiothoracic and vascular anesthesia 20120401
Use of tranexamic acid in pediatric cardiac surgery: we really need more. Journal of anesthesia 20120401
Comparison of whole blood fibrin-based clot tests in thrombelastography and thromboelastometry. Anesthesia and analgesia 20120401
Congenital diaphragmatic hernia: to repair on or off extracorporeal membrane oxygenation? Journal of pediatric surgery 20120401
[Antiplatelet drugs - implications for the anesthesiologist]. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20120401
Prohemostatic interventions in obstetric hemorrhage. Seminars in thrombosis and hemostasis 20120401
Recombinant Factor VIIa in Post-partum Hemorrhage: A New Weapon in Obstetrician's Armamentarium. North American journal of medical sciences 20120401
Management of chronic urticaria in Asia: 2010 AADV consensus guidelines. Asia Pacific allergy 20120401
Excessive uterine bleeding. Adolescent medicine: state of the art reviews 20120401
Tranexamic acid: a review of its use in the treatment of hyperfibrinolysis. Drugs 20120326
Bringing women to the forefront of science and medicine. Lancet (London, England) 20120310
Allogeneic single-donor cryoseal produced from fresh-frozen quarantine apheresis plasma as alternative for multidonor or autologous fibrin sealants. Transfusion 20120301
Disruption of the mucosal barrier during gut ischemia allows entry of digestive enzymes into the intestinal wall. Shock (Augusta, Ga.) 20120301
Successful management of hereditary angioedema during tonsillectomy: a case report. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20120301
Comparative analysis of antifibrinolytic medications in pediatric heart surgery. The Journal of thoracic and cardiovascular surgery 20120301
Reducing blood losses and transfusion requirements in craniosynostosis surgery: an endless quest? Anesthesiology 20120301
Postoperative bleeding after dental extraction in liver pretransplant patients. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20120301
Pregnancy after complex myomectomy: neither age of patient nor size, number or location of fibroids should be a barrier. JRSM short reports 20120301
Subarachnoid hemorrhage mimicking leakage of contrast media after coronary angiography. Korean circulation journal 20120301
[Secondary prevention in trauma pathology. Is there an influence of commercial interests on evidence implementation?]. Medicina clinica 20120204
Antiplatelet and anticoagulant drugs in interventional radiology. Cardiovascular and interventional radiology 20120201
Is tranexamic acid really an alternative to aprotinin? European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20120201
Granulomatous interstitial nephritis associated with atypical drug-induced hypersensitivity syndrome induced by carbamazepine. Clinical and experimental nephrology 20120201
Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs) Study. Archives of surgery (Chicago, Ill. : 1960) 20120201
An overview of three promising mechanical, optical, and biochemical engineering approaches to improve selective photothermolysis of refractory port wine stains. Annals of biomedical engineering 20120201
Massive obstetric haemorrhage with disseminated intravascular coagulopathy. Best practice & research. Clinical obstetrics & gynaecology 20120201
Management of coagulation: an Australian perspective. Current opinion in anaesthesiology 20120201
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International consensus and practical guidelines on the gynecologic and obstetric management of female patients with hereditary angioedema caused by C1 inhibitor deficiency. The Journal of allergy and clinical immunology 20120201
Therapeutic monitoring of tranexamic acid concentration: high-throughput analysis with solid-phase microextraction. Therapeutic drug monitoring 20120201
Early recovery after fast-track Oxford unicompartmental knee arthroplasty. 35 patients with minimal invasive surgery. Acta orthopaedica 20120201
Antifibrinolytics in trauma patients: does it MATTER? Archives of surgery (Chicago, Ill. : 1960) 20120201
[Quincke's oedema or angioedema]. La Revue du praticien 20120201
Intranasal tranexamic acid for the treatment of hereditary hemorrhagic telangiectasia: a case report and review of treatment options. Cutis 20120201
Effectiveness of tranexamic acid in revision total knee arthroplasty. Acta orthopaedica Belgica 20120201
The frequency of thrombotic events among adults given antifibrinolytic drugs for spontaneous bleeding: systematic review and meta-analysis of observational studies and randomized trials. Current drug safety 20120201
The levonorgestrel-releasing intrauterine system in heavy menstrual bleeding: a benefit-risk review. Drugs 20120122
Tranexamic acid for upper gastrointestinal bleeding. The Cochrane database of systematic reviews 20120118
[Emergency medicine: updates 2011]. Revue medicale suisse 20120111
[Tranexamic acid reduces blood loss after major elective orthopaedic operations]. Ugeskrift for laeger 20120109
Risk of deep venous thrombosis in drain clamping with tranexamic acid and carbazochrome sodium sulfonate hydrate in total knee arthroplasty. The Journal of arthroplasty 20120101
Laparoscopic subtotal hysterectomy in a case of uterine didelphys. Archives of gynecology and obstetrics 20120101
Thrombocytopenia and bleeding in dental procedures of patients with Gaucher disease. Haemophilia : the official journal of the World Federation of Hemophilia 20120101
Clot lysis time in platelet-rich plasma: method assessment, comparison with assays in platelet-free and platelet-poor plasmas, and response to tranexamic acid. Platelets 20120101
Which is more effective in adolescent idiopathic scoliosis surgery: batroxobin, tranexamic acid or a combination? Archives of orthopaedic and trauma surgery 20120101
Bleeding in congenital hemangiomas: crusting as a clinical predictive sign and usefulness of tranexamic acid. Pediatric dermatology 20120101
Trauma-associated hyperfibrinolysis. Hamostaseologie 20120101
Effect of tranexamic acid on transfusion requirement in dual antiplatelet-treated anemic patients undergoing off-pump coronary artery bypass graft surgery. Circulation journal : official journal of the Japanese Circulation Society 20120101
Use of a novel technique, solid phase microextraction, to measure tranexamic acid in patients undergoing cardiac surgery. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20120101
'Seizing' the opportunity to understand antifibrinolytic drugs. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20120101
High-dose tranexamic acid is an independent predictor of early seizure after cardiopulmonary bypass. The Annals of thoracic surgery 20120101
Seizures following cardiac surgery: the impact of tranexamic acid and other risk factors. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20120101
Menorrhagia and bleeding disorders in adolescent females. Hamostaseologie 20120101
[Use of desmopressin in children with inherited platelet dysfunctions undergoing adenotonsillar procedures]. Acta otorrinolaringologica espanola 20120101
Invited commentary. The Annals of thoracic surgery 20120101
Use of topical tranexamic acid or aminocaproic acid to prevent bleeding after major surgical procedures. The Annals of pharmacotherapy 20120101
Evaluation and management of abnormal uterine bleeding in premenopausal women. American family physician 20120101
Are tranexamic acid and ε-aminocaproic acid adequate substitutes for aprotinin? Annals of cardiac anaesthesia 20120101
Risk factors associated with postoperative seizures in patients undergoing cardiac surgery who received tranexamic acid: a case-control study. Annals of cardiac anaesthesia 20120101
Utility of Sonoclot analysis and tranexamic acid in tetralogy of Fallot patients undergoing intracardiac repair. Annals of cardiac anaesthesia 20120101
Two distinct coagulase-dependent barriers protect Staphylococcus aureus from neutrophils in a three dimensional in vitro infection model. PLoS pathogens 20120101
Counselling patients with uterine fibroids: a review of the management and complications. Obstetrics and gynecology international 20120101
1H-NMR-based metabolic profiling of maternal and umbilical cord blood indicates altered materno-foetal nutrient exchange in preterm infants. PloS one 20120101
Is management of acute traumatic brain injury effective? A literature review of published Cochrane Systematic Reviews. Chinese journal of traumatology = Zhonghua chuang shang za zhi 20120101
In silico insights into the symbiotic nitrogen fixation in Sinorhizobium meliloti via metabolic reconstruction. PloS one 20120101
The use of antivascular endothelial growth factor agents in the perioperative period in diabetic vitrectomy. Middle East African journal of ophthalmology 20120101
Early and individualized goal-directed therapy for trauma-induced coagulopathy. Scandinavian journal of trauma, resuscitation and emergency medicine 20120101
Avoidable mortality from giving tranexamic acid to bleeding trauma patients: an estimation based on WHO mortality data, a systematic literature review and data from the CRASH-2 trial. BMC emergency medicine 20120101
Efficacy of tranexamic acid on blood loss during bimaxilary osteotomy: A randomized double blind clinical trial. Saudi journal of anaesthesia 20120101
CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage) intracranial bleeding study: the effect of tranexamic acid in traumatic brain injury--a nested randomised, placebo-controlled trial. Health technology assessment (Winchester, England) 20120101
The use of tranexamic acid for trauma patients? CJEM 20120101
Medical therapy with tranexamic acid in autosomal dominant polycystic kidney disease patients with severe haematuria. Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20120101
Emerging treatment strategies for trauma-induced coagulopathy. The British journal of surgery 20120101
Platelet function in stored heparinised autologous blood is not superior to in patient platelet function during routine cardiopulmonary bypass. PloS one 20120101
Tranexamic acid for traumatic hemorrhage. Revista do Colegio Brasileiro de Cirurgioes 20120101
High levels of soluble VEGF receptor 1 early after trauma are associated with shock, sympathoadrenal activation, glycocalyx degradation and inflammation in severely injured patients: a prospective study. Scandinavian journal of trauma, resuscitation and emergency medicine 20120101
Massive sublingual hematoma secondary to anticoagulant therapy complicated by a traumatic denture: a case report. Journal of medical case reports 20120101
Successfully improving ocular drug delivery using the cationic nanoemulsion, novasorb. Journal of drug delivery 20120101
A randomized prospective analysis of alteration of hemostatic function in patients receiving tranexamic acid and hydroxyethyl starch (130/0.4) undergoing off pump coronary artery bypass surgery. Annals of cardiac anaesthesia 20120101
[Hereditary angioedema. A therapeutic guide]. Medicina 20120101
Successful Long Term Eradication of Factor VIII Inhibitor in Patients with Acquired Haemophilia A in Saudi Arabia. Mediterranean journal of hematology and infectious diseases 20120101
Hemostasis in laparoscopic renal surgery. Indian journal of urology : IJU : journal of the Urological Society of India 20120101
Anesthesia for bone replacement surgery. Journal of anaesthesiology, clinical pharmacology 20120101
An unusual case of pleural-based tumor with life-threatening post-operative complication. Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine 20120101
Accidental intrathecal injection of tranexamic Acid. Case reports in anesthesiology 20120101
Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis. BMJ (Clinical research ed.) 20120101
Hematological evaluation of acquired von Willebrand syndrome before oral surgery: Management of an unusual case. Asian journal of transfusion science 20120101
The Use of Preoperative Epoetin-α in Revision Hip Arthroplasty. The open orthopaedics journal 20120101
Dabigatran for stroke prevention in nonvalvular atrial fibrillation: answers to challenging 'real-world' questions. Thrombosis 20120101
Efficacy of esomeprazole in treating acid-related diseases in Japanese populations. Clinical and experimental gastroenterology 20120101
The Link between Hypersensitivity Syndrome Reaction Development and Human Herpes Virus-6 Reactivation. International journal of hepatology 20120101
Anesthetic Considerations in Hepatectomies under Hepatic Vascular Control. HPB surgery : a world journal of hepatic, pancreatic and biliary surgery 20120101
Medication error: Subarachnoid injection of tranexamic acid. Indian journal of anaesthesia 20120101
CRASH-3 - tranexamic acid for the treatment of significant traumatic brain injury: study protocol for an international randomized, double-blind, placebo-controlled trial. Trials 20120101
Breakdown of mucin as barrier to digestive enzymes in the ischemic rat small intestine. PloS one 20120101
Long-term prophylaxis in hereditary angio-oedema: a systematic review. BMJ open 20120101
Oral modified-release tranexamic acid for heavy menstrual bleeding. The Annals of pharmacotherapy 20120101
Temporary clamping of drain combined with tranexamic acid reduce blood loss after total knee arthroplasty: a prospective randomized controlled trial. BMC musculoskeletal disorders 20120101
Predicting early death in patients with traumatic bleeding: development and validation of prognostic model. BMJ (Clinical research ed.) 20120101
Tranexamic acid: a new option for heavy menstrual bleeding. Nursing for women's health 20120101
Tranexamic acid in total knee replacement surgeries: Some concerns. Indian journal of anaesthesia 20120101
Risk factors of neurological complications in cardiac surgery. Kardiologia polska 20120101
Tranexamic acid for the treatment of heavy menstrual bleeding: efficacy and safety. International journal of women's health 20120101
Effect of tranexamic acid on mortality in patients with traumatic bleeding: prespecified analysis of data from randomised controlled trial. BMJ (Clinical research ed.) 20120101
Risks of harms using antifibrinolytics in cardiac surgery: systematic review and network meta-analysis of randomised and observational studies. BMJ (Clinical research ed.) 20120101
Evaluation and Comparison of Using Low-Dose Aprotinin and Tranexamic Acid in CABG: a Double Blind Randomized Clinical Trial. The journal of Tehran Heart Center 20120101
[Risk of bleeding and haemorrhagic complication with rivaroxaban--periprocedural management of haemostasis]. Hamostaseologie 20120101
Determination of tranexamic acid concentration by solid phase microextraction and liquid chromatography-tandem mass spectrometry: first step to in vivo analysis. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111215
Methods to decrease blood loss and transfusion requirements for liver transplantation. The Cochrane database of systematic reviews 20111207
Safety of tranexamic acid in pediatric cardiac surgery: what we do not know. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20111201
Effect of warfarin on menstruation and menstrual management of the adolescent on warfarin. Journal of paediatrics and child health 20111201
Plasmin: its role in the extracellular processing of progalanin in tumor tissue. Protein and peptide letters 20111201
Effect of intravenous tranexamic acid administration on blood loss during and after cesarean delivery. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20111201
Tranexamic acid for postpartum bleeding. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20111201
Tranexamic acid could really be recommended in case of subarachnoid hemorrhage? Neurosurgery 20111201
Effect of tranexamic acid on blood loss in pediatric cardiac surgery: a randomized trial. Journal of anesthesia 20111201
First-line therapy with coagulation factor concentrates combined with point-of-care coagulation testing is associated with decreased allogeneic blood transfusion in cardiovascular surgery: a retrospective, single-center cohort study. Anesthesiology 20111201
Melasma: treatment strategy. Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology 20111201
Reduction of blood loss in primary hip arthroplasty with tranexamic acid or fibrin spray. Acta orthopaedica 20111201
Why still in hospital after fast-track hip and knee arthroplasty? Acta orthopaedica 20111201
[Role of medical treatment for symptomatic leiomyoma management in premenopausal women]. Journal de gynecologie, obstetrique et biologie de la reproduction 20111201
Tranexamic acid--a recipe for saving lives in traumatic bleeding. Journal of primary health care 20111201
The effect of intravenous tranexamic acid on blood loss and surgical field quality during endoscopic sinus surgery: a placebo-controlled clinical trial. Journal of clinical anesthesia 20111201
Tranexamic acid in total knee replacement: a systematic review and meta-analysis. The Journal of bone and joint surgery. British volume 20111201
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS computational biology 20111201
Complete bilateral ureteral obstruction following retrograde catheterization and radical hysterectomy. Taiwanese journal of obstetrics & gynecology 20111201
[Study on the haemostatic efficiency of composite bio-particles]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20111201
Randomised surgical trials need good surgical outcomes in the control arm. BMJ (Clinical research ed.) 20111122
CRASH-2 goes viral. Lancet (London, England) 20111119
You can stop the bleeding. BMJ (Clinical research ed.) 20111117
Interventions to reduce haemorrhage during myomectomy for fibroids. The Cochrane database of systematic reviews 20111109
Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty. International orthopaedics 20111101
Tranexamic acid reduces perioperative blood loss in cervical laminoplasty: a prospective randomized study. Spine 20111101
Metastasis: recent discoveries and novel perioperative treatment strategies with particular interest in the hemostatic compound desmopressin. Current pharmaceutical biotechnology 20111101
Conservative management of a haemorrhagic adnexal cyst in a patient with Type 3 von Willebrand Disease. European journal of obstetrics, gynecology, and reproductive biology 20111101
Optimizing cost-effectiveness in perioperative care for liver transplantation: a model for low- to medium-income countries. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20111101
Long-term evaluation of safety and health-related quality of life in women with heavy menstrual bleeding treated with oral tranexamic acid. Women's health (London, England) 20111101
Ischaemic stroke following tranexamic acid in young patients carrying heterozygosity of MTHFR C677T. Annals of clinical biochemistry 20111101
Nonhormonal treatments for heavy menstrual bleeding. Journal of women's health (2002) 20111101
Management of menorrhagia associated with chemotherapy-induced thrombocytopenia in women with hematologic malignancy. Pharmacotherapy 20111101
Therapy refractory menorrhagia as first manifestation of Hermansky-Pudlak syndrome. Hamostaseologie 20111101
Tranexamic acid autoinjector for prehospital care of noncompressible hemorrhage. The Journal of trauma 20111101
The prophylactic use of recombinant factor VIIa in a patient with DeBakey type III aortic dissection -A case report-. Korean journal of anesthesiology 20111101
Traumatic hemorrhagic shock: advances in fluid management. Emergency medicine practice 20111101
[Tranexamic acid after myocardial infarction. Referral to coagulation unit is recommended]. Lakartidningen 20111101
Tranexamic Acid - a recipe for saving lives in traumatic bleeding. The journal of Tehran Heart Center 20111101
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research 20111001
Local and systemic application of tranexamic acid in heart valve surgery: a prospective, randomized, double blind LOST study. Journal of thrombosis and thrombolysis 20111001
A dose-response study of a novel, oral tranexamic formulation for heavy menstrual bleeding. American journal of obstetrics and gynecology 20111001
Efficacy of prophylactic low dose of tranexamic acid in spinal fixation surgery: a randomized clinical trial. Journal of neurosurgical anesthesiology 20111001
Use of tranexamic acid as a rescue measure to achieve hemostasis after massive blood loss in a pediatric neurosurgical patient. Journal of neurosurgical anesthesiology 20111001
Enhanced recovery program for hip and knee replacement reduces death rate. Acta orthopaedica 20111001
Fibrin sealant (evicel® [quixil®/crosseal™]): a review of its use as supportive treatment for haemostasis in surgery. Drugs 20111001
Tranexamic acid--a recipe for saving lives in traumatic bleeding. International journal of epidemiology 20111001
Craniostenosis. Journal of pediatric neurosciences 20111001
Stereotactic brainstem biopsy in a patient with coagulopathy of unclear etiology: case report. Minimally invasive neurosurgery : MIN 20111001
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Recombinant factor VIIa to prevent surgical bleeding in factor XI deficiency. Haemophilia : the official journal of the World Federation of Hemophilia 20080701
Plasmin induces degradation and dysfunction of laminin 332 (laminin 5) and impaired assembly of basement membrane at the dermal-epidermal junction. The British journal of dermatology 20080701
Aprotinin is not associated with postoperative renal impairment after primary coronary surgery. The Annals of thoracic surgery 20080701
Hereditary haemorrhagic telangiectasia (HHT): negotiating between the Scylla of bleeding and Charybdis of thrombosis. Thrombosis and haemostasis 20080701
Epistaxis in adults: a clinical review. British journal of hospital medicine (London, England : 2005) 20080701
Effect of antifibrinolytic drugs on transfusion requirement and blood loss during orthotopic liver transplantation: Results from a single center. Asian journal of transfusion science 20080701
Structure and mutagenic conversion of E1 dehydrase: at the crossroads of dehydration, amino transfer, and epimerization. Biochemistry 20080617
Acute myocardial infarction following tranexamic acid use in a low cardiovascular risk setting. British journal of haematology 20080601
Desmoteplase-mediated plasminogen activation and clot lysis are inhibited by the lysine analogue tranexamic acid. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20080601
Prospective, randomized, controlled trial of tranexamic acid in patients who undergo head and neck procedures. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20080601
Drug-induced immune thrombocytopenic purpura secondary to sunitinib. Current oncology (Toronto, Ont.) 20080601
A comparison of aprotinin and lysine analogues in high-risk cardiac surgery. The New England journal of medicine 20080529
Systematic review: tranexamic acid for upper gastrointestinal bleeding. Alimentary pharmacology & therapeutics 20080501
Acquired transitory factor XI inhibitor after gynaecological surgery. Haemophilia : the official journal of the World Federation of Hemophilia 20080501
Does perioperative use of aprotinin reduce the rejection rate in heart transplant recipients? European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20080501
Gd-complexes of DTPA-bis(amide) conjugates of tranexamic acid and its esters with high relaxivity and stability for magnetic resonance imaging. Dalton transactions (Cambridge, England : 2003) 20080428
[Drugs to reduce transfusion needs during surgery]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20080403
Intravenous tranexamic acid use in myomectomy: a prospective randomized double-blind placebo controlled study. European journal of obstetrics, gynecology, and reproductive biology 20080401
In vitro simulation of thrombolysis inhibition. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20080401
Non-surgical bleeding in patients with ventricular assist devices could be explained by acquired von Willebrand disease. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20080401
Antifibrinolytic therapy in surgery for congenital heart disease. Anesthesia and analgesia 20080401
Postoperative bleeding in cardiac surgery: the role of tranexamic acid in patients homozygous for the 5G polymorphism of the plasminogen activator inhibitor-1 gene. Anesthesiology 20080401
Hemostatic therapy for the treatment of intracranial hemorrhage. Pharmacotherapy 20080401
A preliminary study of a new tranexamic acid dosing schedule for cardiac surgery. Journal of cardiothoracic and vascular anesthesia 20080401
Re: Shapiro F, Zurakowski D, Sethna NF. Tranexamic acid diminishes intraoperative blood loss and transfusion in spinal fusion for Duchenne muscular dystrophy scoliosis. Spine 2007;32:2278-83. Spine 20080401
Current antifibrinolytic therapy for coronary artery revascularization. AANA journal 20080401
Prevalence of claustrophobia and magnetic resonance imaging after coronary artery bypass graft surgery. Neuropsychiatric disease and treatment 20080401
[A multicenter prospective randomized open comparative study on the treatment of ovulatory menorrhagia with tranexamic acid and norethisterone in China]. Zhonghua fu chan ke za zhi 20080401
Plasminogen potentiates thrombin cytotoxicity and contributes to pathology of intracerebral hemorrhage in rats. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20080301
Tranexamic acid reduces blood transfusion in total knee arthroplasty even when a blood conservation program is applied. Transfusion 20080301
Pharmacologic methods to reduce perioperative bleeding. Transfusion 20080301
Trial of angioembolization of advanced stage tumors feeding arteries exemplifying aggressive and active interventional palliation. Journal of palliative medicine 20080301
Effect of aprotinin on renal dysfunction in patients undergoing on-pump and off-pump cardiac surgery: a retrospective observational study. Lancet (London, England) 20080209
Aspirin and Tranexamic Acid for Coronary Artery Surgery (ATACAS) Trial: rationale and design. American heart journal 20080201
Possible disease-modifying factors: the mannan-binding lectin pathway and infections in hereditary angioedema of children and adults. Archivum immunologiae et therapiae experimentalis 20080201
[Stroke, tranexamic acid and patent foramen ovale]. Revista de neurologia 20080201
Prevention of cardiac surgery-associated acute kidney injury. The International journal of artificial organs 20080201
[Effectiveness of tranexamic acid in routine performance of total knee replacement surgery]. Revista espanola de anestesiologia y reanimacion 20080201
Guideline for the treatment of haemophilia in South Africa. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 20080201
Use and outcomes of antifibrinolytic therapy in patients undergoing cardiothoracic surgery at 20 academic medical centers in the United States. P & T : a peer-reviewed journal for formulary management 20080201
Pharmacovigilance: Safety matters…. Indian journal of pharmacology 20080201
Cyclical progestogens for heavy menstrual bleeding. The Cochrane database of systematic reviews 20080123
Recombinant human activated factor VII in postpartum hemorrhagic shock: the dark side. Intensive care medicine 20080101
Practice pearl: a novel use of tranexamic Acid for decreasing the blood loss of aneurysmal bone cyst ablation. Annals of surgical oncology 20080101
Protective role of thrombin activatable fibrinolysis inhibitor in obstructive nephropathy-associated tubulointerstitial fibrosis. Journal of thrombosis and haemostasis : JTH 20080101
A Jehovah's Witness child with hemophilia B and factor IX inhibitors undergoing scoliosis surgery. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20080101
Management of menorrhagia in women with inherited bleeding disorders: general principles and use of desmopressin. Haemophilia : the official journal of the World Federation of Hemophilia 20080101
An anti-inflammatory role for tranexamic acid in cardiac surgery? Critical care (London, England) 20080101
Recombinant activated factor VIIa for the treatment of bleeding in major abdominal surgery including vascular and urological surgery: a review and meta-analysis of published data. Critical care (London, England) 20080101
Primary intestinal lymphangiectasia (Waldmann's disease). Orphanet journal of rare diseases 20080101
A benefit-risk review of systemic haemostatic agents: part 1: in major surgery. Drug safety 20080101
A benefit-risk review of systemic haemostatic agents: part 2: in excessive or heavy menstrual bleeding. Drug safety 20080101
[Expressions of urotensin II and its receptor in pulmonary arteries in rats with chronic thromboembolic pulmonary hypertension]. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20080101
Gastric antral vascular ectasia (GAVE): an update on clinical presentation, pathophysiology and treatment. Digestion 20080101
Third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke. Trials 20080101
Development of vitreous haemorrhage during treatment with bevacizumab for metastatic rectal cancer. Clinical drug investigation 20080101
[The in vitro cross-effects of inhibitors of renin-angiotensin and fibrinolytic systems on the key enzymes of these systems]. Bioorganicheskaia khimiia 20080101
A Dutch guideline for the treatment of scoliosis in neuromuscular disorders. Scoliosis 20080101
The short-term medical management of non-variceal upper gastrointestinal bleeding. Drugs 20080101
Membranous nephropathy in a patient with hereditary angioedema: a case report. Journal of medical case reports 20080101
Year in review 2007: Critical Care--cardiology. Critical care (London, England) 20080101
Drug use in children: cohort study in three European countries. BMJ (Clinical research ed.) 20080101
Post partum haemorrhage secondary to uterine atony, complicated by platelet storage pool disease and partial placenta diffusa: a case report. Cases journal 20080101
Periodontal considerations for Glanzmann's thrombasthenic patient. Journal of Indian Society of Periodontology 20080101
[Antifibrinolytic agents and repeat open-heart surgery: a comparison of tranexamic acid and low dose aprotinin]. Annales de cardiologie et d'angeiologie 20071201
Tranexamic acid combined with recombinant factor VIII increases clot resistance to accelerated fibrinolysis in severe hemophilia A. Journal of thrombosis and haemostasis : JTH 20071201
Successful combined use of tranexamic acid and unfractionated heparin for life-threatening bleeding associated with intravascular coagulation in a patient with chronic myelogenous leukemia in blast crisis. International journal of hematology 20071201
[Clinical comparative studies on effect of tranexamic acid on blood loss associated with total knee arthroplasty]. Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery 20071201
Antifibrinolytic therapy: evidence, bias, confounding (and politics!). The journal of extra-corporeal technology 20071201
Hypoplasminogenaemia, gingival swelling and ulceration. Oral diseases 20071101
[Side effects of gastric muco-protective agents]. Nihon rinsho. Japanese journal of clinical medicine 20071028
Nonsteroidal anti-inflammatory drugs for heavy menstrual bleeding. The Cochrane database of systematic reviews 20071017
Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. The Cochrane database of systematic reviews 20071017
Treatment of vaginal bleeding irregularities induced by progestin only contraceptives. The Cochrane database of systematic reviews 20071017
[Dysfunctionnal uterin bleedings]. Journal de gynecologie, obstetrique et biologie de la reproduction 20071001
Evaluation of aprotinin and tranexamic acid in different in vitro and in vivo models of fibrinolysis, coagulation and thrombus formation. Journal of thrombosis and haemostasis : JTH 20071001
A bleeding tongue - acute presentation of fibrinolysis. International journal of laboratory hematology 20071001
Amine modification of digested peptide at C-terminal end during protein digestion by protease. Biological & pharmaceutical bulletin 20071001
The onerous task of comparing treatments in inhibitor patients. Thrombosis and haemostasis 20071001
[Antifibrinolytics and cardiac surgery with cardiopulmonary bypass.]. Revista brasileira de anestesiologia 20071001
Tranexamic acid diminishes intraoperative blood loss and transfusion in spinal fusions for duchenne muscular dystrophy scoliosis. Spine 20070915
Hepatic veno-occlusive disease after tranexamic acid administration in patients undergoing allogeneic hematopoietic stem cell transplantation. American journal of hematology 20070901
Perioperative management of four anaemic female Jehovah's Witnesses undergoing urgent complex cardiac surgery. British journal of anaesthesia 20070901
Standards expected while reporting a critical incident. Anesthesia and analgesia 20070901
Antifibrinolytic use in adult cardiac surgery. Current opinion in hematology 20070901
Plasminogen is an important regulator in the pathogenesis of a murine model of asthma. American journal of respiratory and critical care medicine 20070815
Does tranexamic acid reduce blood loss in off-pump coronary artery bypass? Asian cardiovascular & thoracic annals 20070801
Tranexamic acid and primary coronary artery bypass surgery: a prospective study. Asian cardiovascular & thoracic annals 20070801
Tranexamic acid-associated necrosis and intralesional thrombosis of uterine leiomyomas: a clinicopathologic study of 147 cases emphasizing the importance of drug-induced necrosis and early infarcts in leiomyomas. The American journal of surgical pathology 20070801
Simple, rapid, and sensitive liquid chromatography-fluorescence method for the quantification of tranexamic acid in blood. Journal of chromatography. A 20070720
Danazol for heavy menstrual bleeding. The Cochrane database of systematic reviews 20070718
Comparison of structure, strength and cytocompatibility of a fibrin matrix supplemented either with tranexamic acid or aprotinin. Journal of biomedical materials research. Part B, Applied biomaterials 20070701
Mitochondrial aspartate aminotransferase: a third kynurenate-producing enzyme in the mammalian brain. Journal of neurochemistry 20070701
Efficacy of tidal irrigation in Milwaukee shoulder syndrome. The Journal of rheumatology 20070701
Determination of the global fibrinolytic state. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20070701
New approach to the evaluation of skin color of pigmentary lesions using Skin Tone Color Scale. The Journal of dermatology 20070701
The use of topical crushed tranexamic acid tablets to control bleeding after dental surgery and from skin ulcers in haemophilia. Haemophilia : the official journal of the World Federation of Hemophilia 20070701
Approach to the diagnosis and management of mild bleeding disorders. Journal of thrombosis and haemostasis : JTH 20070701
Menorrhagia associated with laboratory abnormalities of hemostasis: epidemiological, diagnostic and therapeutic aspects. Journal of thrombosis and haemostasis : JTH 20070701
Mechanism of action of omega-amino acids on plasminogen activation and fibrinolysis induced by staphylokinase. Biochemistry. Biokhimiia 20070701
[A patient with repeated, life-threatening gastro-intestinal haemorrhages treated by means of medication, open surgery, endoscopic surgery, intervention radiology and conservative methods]. Nederlands tijdschrift voor geneeskunde 20070623
Meta-analysis comparing the effectiveness and adverse outcomes of antifibrinolytic agents in cardiac surgery. Circulation 20070605
Tranexamic acid and uremic bleeding: evidence-based treatment recommendations. Nature clinical practice. Nephrology 20070601
The levonorgestrel-releasing intrauterine system as an alternative to hysterectomy in peri-menopausal women. Contraception 20070601
Role of tissue-plasminogen activator (t-PA) in a mouse model of neonatal white matter lesions: interaction with plasmin inhibitors and anti-inflammatory drugs. Neuroscience 20070511
A case of hereditary angio-oedema type III presenting with C1-inhibitor cleavage and a missense mutation in the F12 gene. The British journal of dermatology 20070501
Perioperative use of modified thrombelastography in factor XI deficiency: a helpful method to assess drug effects. Acta anaesthesiologica Scandinavica 20070501
[Practical management of C1 inhibitor deficiency]. Actas dermo-sifiliograficas 20070501
Bloodless surgery in a patient with thalassemia minor. Usefulness of erythropoietin, preoperative blood donation and intraoperative blood salvage. Minerva anestesiologica 20070501
[Treatment of bleeding gastroduodenal ulcer]. Ugeskrift for laeger 20070423
Pharmacologic treatment of peptic ulcer bleeding. Current treatment options in gastroenterology 20070401
[Treatment of epistaxes in hereditary haemorrhagic telangiectasia (Rendu-Osler-Weber disease) with tranexamic acid]. Acta otorrinolaringologica espanola 20070401
[Obstetric analgesia for a women with type III hereditary angioneurotic edema]. Revista espanola de anestesiologia y reanimacion 20070401
Topical use of antifibrinolytic agents reduces postoperative bleeding: a double-blind, prospective, randomized study. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20070301
Recombinant activated factor VII for hemostatic cover of orthopedic interventions in a girl with thrombocytopenia with absent radii syndrome. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20070301
Spectrophotometric and spectrofluorimetric methods for the determination of tranexamic acid in pharmaceutical formulation. Chemical & pharmaceutical bulletin 20070301
Clinical practice and evidence in endoscopic treatment of bleeding peptic gastroduodenal ulcer. Scandinavian journal of gastroenterology 20070301
Intestinal lymphangiectasia: a rare cause of gastrointestinal bleeding? Scandinavian journal of gastroenterology 20070301
Comparison of topical fibrin spray and tranexamic acid on blood loss after total knee replacement: a prospective, randomised controlled trial. The Journal of bone and joint surgery. British volume 20070301
Management of dental patients taking common hemostasis-altering medications. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20070301
[Effect of tranexamic acid on postoperative bleeding in pediatric heart surgery]. Revista espanola de anestesiologia y reanimacion 20070301
Medical management of perimenopausal menorrhagia: an evidence-based approach. Menopause international 20070301
Mortality associated with aprotinin during 5 years following coronary artery bypass graft surgery. JAMA 20070207
[Local and systemic hemostasis in surgery]. Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen 20070201
Menorrhagia due to abnormalities of the platelet function: evaluation of two young patients. Pediatrics international : official journal of the Japan Pediatric Society 20070201
Anti-inflammatory strategies and hemostatic agents: old drugs, new ideas. Hematology/oncology clinics of North America 20070201
Therapeutic action of tranexamic acid in hereditary haemorrhagic telangiectasia (HHT): regulation of ALK-1/endoglin pathway in endothelial cells. Thrombosis and haemostasis 20070201
Are gastroprotective drugs useful for gastric ulcer healing: re-evaluation using current ICH E9 guidelines. Inflammopharmacology 20070201
Non-surgical management of heavy menstrual bleeding. Nursing times 20070201
Predictors of hematoma enlargement in patients with intracerebral hemorrhage treated with rapid administration of antifibrinolytic agents and strict blood pressure control. Journal of neurosurgery 20070201
Aprotinin; friend or foe? A review of recent medical literature. European journal of anaesthesiology 20070101
Risk of rebleeding after treatment of acute hydrocephalus in patients with aneurysmal subarachnoid hemorrhage. Stroke 20070101
Death after an inadvertent intrathecal injection of tranexamic acid. Anesthesia and analgesia 20070101
Topical use of tranexamic acid to control perioperative local bleeding in gynaecology patients with clotting disorders: two cases. Haemophilia : the official journal of the World Federation of Hemophilia 20070101
Efficacy and safety of antifibrinolytic drugs in liver transplantation: a systematic review and meta-analysis. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20070101
Effects of tranexamic acid and autotransfusion in coronary artery bypass. Asian cardiovascular & thoracic annals 20070101
Plasminogen binding and activation at the breast cancer cell surface: the integral role of urokinase activity. Breast cancer research : BCR 20070101
[Angioedema. Cause, clinical presentation, diagnosis and treatment]. Medizinische Monatsschrift fur Pharmazeuten 20070101
[Small flexible drains after cardiac surgery. Efficacy and safety of a new system]. Cirugia espanola 20070101
Recombinant activated factor VII and epsilon aminocaproic acid treatment of a patient with Glanzmann's thrombasthenia for nasal polipectomy. Journal of anesthesia 20070101
Management of bleeding following major trauma: a European guideline. Critical care (London, England) 20070101
Cronkhite-Canada syndrome associated with schizophrenia. Internal medicine (Tokyo, Japan) 20070101
A neonatal presentation of factor V deficiency: a case report. BMC pediatrics 20070101
The CRASH-2 trial of an antifibrinolytic agent in traumatic haemorrhage: an international collaboration. The Indian journal of medical research 20070101
Minimally invasive cardiopulmonary bypass: does it really change the outcome? Critical care (London, England) 20070101
Failure of recombinant factor VIIa in a patient with severe polymicrobial sepsis and postoperative uncontrolled intraabdominal bleeding. BMC infectious diseases 20070101
Diagnosis and treatment of menorrhagia. Acta obstetricia et gynecologica Scandinavica 20070101
Practice pearl: a novel anesthetic solution for decreasing the blood loss at the recipient site of hair transplantation (Namazi Solution). Aesthetic plastic surgery 20070101
[Efficacy of recombinant activated factor VII for treatment of life-threatening bleeding in cardiac surgery]. Annales francaises d'anesthesie et de reanimation 20070101
Spectrofluorimetric determination of tranexamic acid in hydrogel patch formulations by derivatization with naphthalene-2,3-dicarboxaldehyde/cyanide. Journal of cosmetic science 20070101
Preventive treatment of intrauterine device-induced menstrual blood loss with tranexamic acid in Chinese women. Acta obstetricia et gynecologica Scandinavica 20070101
Is there still a role for aprotinin in cardiac surgery? Drug safety 20070101
Pesticide exposure, risk factors and health problems among cutflower farmers: a cross sectional study. Journal of occupational medicine and toxicology (London, England) 20070101
Determination of the threshold of cardiac troponin I associated with an adverse postoperative outcome after cardiac surgery: a comparative study between coronary artery bypass graft, valve surgery, and combined cardiac surgery. Critical care (London, England) 20070101
Synthesis of 3-substituted-5-(4-carb oxycyclohexylmethyl) - tetrahydro-2H-1,3,5-thiadiazine-2-thione derivatives as antifibrinolytic and antimicrobial agents. Arzneimittel-Forschung 20070101
Recombinant activated factor VII (Novo7) in patients with ventricular assist devices: case report and review of the current literature. Journal of cardiothoracic surgery 20070101
Reduction of blood loss with tranexamic acid in primary total hip replacement surgery. Acta chirurgica Belgica 20070101
Tranexamic acid attenuates inflammatory response in cardiopulmonary bypass surgery through blockade of fibrinolysis: a case control study followed by a randomized double-blind controlled trial. Critical care (London, England) 20070101
Effects of topical antifibrinolytics in endoscopic sinus surgery: a pilot randomized controlled trial. American journal of rhinology 20070101
Angioedema: clinical and etiological aspects. Clinical & developmental immunology 20070101
[Optimization of anesthetic service during abdominal delivery of pregnant women with gestosis]. Anesteziologiia i reanimatologiia 20070101
[Anesthetic service and the postoperative period in pregnant women with gestosis]. Anesteziologiia i reanimatologiia 20070101
[Hemostatic therapy for hemorrhages during first and second trimesters]. Anesteziologiia i reanimatologiia 20070101
Canine plasminogen: spectral responses to changes in 6-aminohexanoate and temperature. Analytical chemistry insights 20070101
The image of pharma. Mens sana monographs 20070101
Hemostatic mouthwashes in anticoagulated patients undergoing dental extraction. The Annals of pharmacotherapy 20061201
Pro: Aprotinin has a good efficacy and safety profile relative to other alternatives for prevention of bleeding in cardiac surgery. Anesthesia and analgesia 20061201
Antifibrinolytic therapy use to mitigate blood loss during staged complex major spine surgery: Postoperative visual color changes after tranexamic acid administration. Anesthesiology 20061201
Aprotinin and renal risk in cardiac surgery. Transfusion 20061201
Aprotinin and tranexamic acid in high-transfusion-risk cardiac surgery. Transfusion 20061201
Acute confusion in an elderly woman with Rendu-Osler-Weber disease. The Israel Medical Association journal : IMAJ 20061201
Clinical update on the therapeutic use of clopidogrel: treatment of acute ST-segment elevation myocardial infarction (STEMI). Vascular health and risk management 20061201
Evidence-based management of epistaxis in adults. British journal of hospital medicine (London, England : 2005) 20061201
Effects on coagulation and fibrinolysis induced by influenza in mice with a reduced capacity to generate activated protein C and a deficiency in plasminogen activator inhibitor type 1. Circulation research 20061124
If you prick us, do we not bleed? Anesthesiology 20061101
Do antifibrinolytics reduce allogeneic blood transfusion in orthopedic surgery? Anesthesiology 20061101
Tranexamic acid does not correct the haemostatic impairment caused by hydroxyethyl starch (200 kDa/0.5) after cardiac surgery. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20061101
Non-steroidal anti-inflammatory drugs for heavy bleeding or pain associated with intrauterine-device use. The Cochrane database of systematic reviews 20061018
No interplay between the pathways mediating coagulation and inflammation in tissue factor-induced disseminated intravascular coagulation in rats. Critical care medicine 20061001
A successful treatment of life-threatening bleeding from polycystic kidneys with antifibrinolytic agent tranexamic acid. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20061001
Hemorrhagic symptoms and bleeding risk in obligatory carriers of type 3 von Willebrand disease: an international, multicenter study. Journal of thrombosis and haemostasis : JTH 20061001
Role of tranexamic acid in management of dysfunctional uterine bleeding in comparison with medroxyprogesterone acetate. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 20061001
Improving the evidence base for trauma care: progress in the international CRASH-2 trial. PLoS clinical trials 20061001
Gynaecological and obstetric management of women with inherited bleeding disorders. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20061001
[Aprotinin in cardiac surgery: more risks than usefulness?]. Der Anaesthesist 20060901
A randomized trial of tranexamic acid in combination with cell salvage plus a meta-analysis of randomized trials evaluating tranexamic acid in off-pump coronary artery bypass grafting. The Journal of thoracic and cardiovascular surgery 20060901
Does salvage and tranexamic acid reduce the need for blood transfusion in revision hip surgery? The Journal of bone and joint surgery. British volume 20060901
The use of antifibrinolytic agents in total hip arthroplasty: a meta-analysis. The Journal of arthroplasty 20060901
Women and von Willebrand disease: controversies in diagnosis and management. Seminars in thrombosis and hemostasis 20060901
[A case of acute exacerbation of chronic pulmonary thromboembolism with essential thrombocythemia during treatment for hemoptysis]. Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20060901
Noninhibitory PAI-1 enhances plasmin-mediated matrix degradation both in vitro and in experimental nephritis. Kidney international 20060801
Perioperative management of a heterozygous carrier of Glanzmann's thrombasthenia submitted to coronary artery bypass grafting with cardiopulmonary bypass. Anesthesia and analgesia 20060801
Management of the dental patient on anticoagulant medication. Dentistry today 20060801
[The 'Seville' Consensus Document on Alternatives to Allogenic Blood Transfusion. Sociedades españolas de Anestesiología (SEDAR), Medicina Intensiva (SEMICYUC), Hematología y Hemoterapia (AEHH), Transfusión sanguínea (SETS) Trombosis y Hemostasia (SETH)]. Medicina clinica 20060718
Current understanding of von Willebrand's disease in women - some answers, more questions. Haemophilia : the official journal of the World Federation of Hemophilia 20060701
Efficacy of FDA-approved hemostatic drugs to improve survival and reduce bleeding in rat models of uncontrolled hemorrhage. Resuscitation 20060701
Effects of cardiac surgery on hemostasis. Transfusion medicine reviews 20060701
Application of ventriculoperitoneal shunt as a treatment for hydrocephalus in a dog with syringomyelia and Chiari I malformation. Journal of veterinary science 20060601
Heparin resistance and increased platelet activation in coronary surgery patients treated with enoxaparin preoperatively. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20060601
Bernard-Soulier syndrome in pregnancy. Clinical and laboratory haematology 20060601
Pharmacological approaches to reducing blood loss and transfusions in the surgical patient. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20060601
Minimizing perioperative blood loss and transfusions in children. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20060601
Trial of drug for trauma patients includes victims of Iraqi violence. BMJ (Clinical research ed.) 20060527
Effect of topical tranexamic acid in open heart surgery. European journal of anaesthesiology 20060501
Efficacy of aminocaproic, tranexamic acids in the control of bleeding during total knee replacement: a randomized clinical trial. British journal of anaesthesia 20060501
Dynamics of amino acid metabolism of primary human liver cells in 3D bioreactors. Bioprocess and biosystems engineering 20060501
Rapid administration of antifibrinolytics and strict blood pressure control for intracerebral hemorrhage. Neurosurgery 20060501
The role of antifibrinolytic agents in gynecologic cancer surgery. Saudi medical journal 20060501
Safety of bypass drug questioned. Harvard heart letter : from Harvard Medical School 20060501
Localized intradermal microinjection of tranexamic acid for treatment of melasma in Asian patients: a preliminary clinical trial. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 20060501
[Tranexamic acid and subarachnoid hemorrhage]. Ugeskrift for laeger 20060501
Tranexamic acid for hemostasis in the surgical treatment of metastatic tumors of the spine. Spine 20060415
Comparison of the effects of aprotinin and tranexamic acid on blood loss and red blood cell transfusion requirements during the late stages of liver transplantation. Transfusion 20060401
Tranexamic acid reduces postoperative bleeding in off-pump coronary artery bypass grafting. Scandinavian cardiovascular journal : SCJ 20060401
Pathophysiology of bleeding in surgery. Transplantation proceedings 20060401
[Effects of different durations of thromboembolism on blood gases, hemodynamics, pulmonary arteriography and thrombo-pathology in a canine model with selective embolization of pulmonary lobar arteries]. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20060401
[Thrombocytopathy and blood complications in uremia]. Wiener klinische Wochenschrift 20060401
[Episodes of angioedema in children with C1 esterase inhibitor deficiency]. Nederlands tijdschrift voor geneeskunde 20060318
['Ultra-early' antifibrinolytic treatment of subarachnoidal bleeding with tranexamic acid]. Ugeskrift for laeger 20060313
Oral surgery in patients on oral anticoagulant therapy: a randomized comparison of different INR targets. Journal of thrombosis and haemostasis : JTH 20060301
The effect of tranexamic acid for treatment of irregular uterine bleeding secondary to Norplant use. Contraception 20060301
Delayed pressure urticaria controlled by tranexamic acid. Clinical and experimental dermatology 20060301
Tranexamic acid reduces early post-operative blood loss after total knee arthroplasty: a prospective randomised controlled trial of 29 patients. The Knee 20060301
Phosphorylcholine coating may limit thrombin formation during high-risk cardiac surgery: a randomized controlled trial. The Annals of thoracic surgery 20060301
Aprotinin versus tranexamic acid: the controversy continues. Transfusion 20060301
A propensity score case-control comparison of aprotinin and tranexamic acid in high-transfusion-risk cardiac surgery. Transfusion 20060301
Pregnancy in a patient of Glanzmann's thrombasthenia. Indian journal of medical sciences 20060301
[Hemostatic drugs in a patient with antiphospholipid syndrome and clinically significant perioperative bleeding]. Revista espanola de anestesiologia y reanimacion 20060301
Perioperative parenteral tranexamic acid in liver tumor resection: a prospective randomized trial toward a 'blood transfusion'-free hepatectomy. Annals of surgery 20060201
Von Willebrand disease. Obstetrical & gynecological survey 20060201
[Serious bleeding in systemic lupus erythematosus complicated by lupus anticoagulant-hypoprothrombinaemia syndrome]. Ugeskrift for laeger 20060130
The risk associated with aprotinin in cardiac surgery. The New England journal of medicine 20060126
A randomized, double-blind, and placebo-controlled study with tranexamic acid of bleeding and fibrinolytic activity after primary coronary artery bypass grafting. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20060101
Ineffective off-label use of recombinant activated factor VII in a case of bone-marrow transplantation-related gastrointestinal bleeding. Thrombosis journal 20060101
Recombinant activated factor VII combined with desmopressin in preventing bleeding from dental extraction in a patient with Glanzmann's thrombasthenia. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20060101
Recent acquisitions in the pathophysiology, diagnosis and treatment of disseminated intravascular coagulation. Thrombosis journal 20060101
Hemostatic effect of tranexamic acid in elective nasal surgery. American journal of rhinology 20060101
CRASH2 in Germany [ISRCTN86750102]. Trials 20060101
Antifibrinolytics in liver transplantation. International anesthesiology clinics 20060101
Coagulation abnormalities in critically ill patients. Critical care (London, England) 20060101
[Willebrand disease]. Revue de l'infirmiere 20060101
The impact of administration of tranexamic acid in reducing the use of red blood cells and other blood products in cardiac surgery. BMC anesthesiology 20060101
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Successful pulmonary administration of activated recombinant factor VII in diffuse alveolar hemorrhage. Critical care (London, England) 20060101
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Comparison of cetraxate-based and pantoprazole-based triple therapies in the treatment of Helicobacter pylori infection. Journal of the Chinese Medical Association : JCMA 20040401
Determination of vigabatrin in human plasma and urine by high-performance liquid chromatography with UV-Vis detection. Journal of chromatography. A 20040326
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The effect of tranexamic acid in fibrin sealant on adhesion formation in the rat. Journal of biomedical materials research. Part B, Applied biomaterials 20040215
Clinical observation of blood loss reduced by tranexamic acid during and after caesarian section: a multi-center, randomized trial. European journal of obstetrics, gynecology, and reproductive biology 20040210
Normal complement C4 values do not exclude hereditary angioedema. Journal of clinical pathology 20040201
The prophylactic use of tranexamic acid and aprotinin in orthotopic liver transplantation: a comparative study. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20040201
Postmenopausal bleeding due to chronic DIC. European journal of obstetrics, gynecology, and reproductive biology 20040115
The regulation of liver regeneration by the plasmin/alpha 2-antiplasmin system. Journal of hepatology 20040101
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Review article: current therapeutic options for gastric antral vascular ectasia. Alimentary pharmacology & therapeutics 20030715
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Prevention of early rebleeding. Journal of neurosurgery 20030501
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[Treatment of chronic idiopathic urticaria unresponsive to type 1 antihistamines in monotherapy]. Annales de dermatologie et de venereologie 20030501
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Recombinant activated factor VII combined with local measures in preventing bleeding from invasive dental procedures in patients with Glanzmann thrombasthenia. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20030201
Successful aortic valve replacement in severe pancytopenia related to myelodysplastic syndrome. The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi 20030201
Convulsions and refractory ventricular fibrillation after intrathecal injection of a massive dose of tranexamic acid. Anesthesiology 20030101
Combination therapy of DDAVP and conjugated estrogens for a recurrent large subcutaneous hematoma in Ehlers-Danlos syndrome. American journal of hematology 20030101
Pharmacological approaches to reducing allogeneic blood exposure. Vox sanguinis 20030101
Safety of dental extraction among consecutive patients on oral anticoagulant treatment managed using a specific dental management protocol. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20030101
Görög Thrombosis Test: a global in-vitro test of platelet function and thrombolysis. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20030101
A splicing donor site point mutation in intron 6 of the plasmin inhibitor (alpha2 antiplasmin) gene with heterozygous deficiency and a bleeding tendency. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20030101
Treatment of anaemia in the polytrauma Jehovah's Witness. Irish medical journal 20030101
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[Anesthetic management of a patient with congenital plasminogen activator inhibitor-1 deficiency]. Masui. The Japanese journal of anesthesiology 20030101
The effect of short-term antifibrinolytic therapy on experimental vasospasm. Surgical neurology 20030101
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Successful treatment of acute promyelocytic leukaemia during pregnancy. Clinical and laboratory haematology 20021001
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