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119630-94-3 | Benzoic acid, 2-[(5α)-4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-ylidene]hydrazide
CAS No: 119630-94-3 Catalog No: AG000PEF MDL No:
Product Description
Catalog Number:
AG000PEF
Chemical Name:
Benzoic acid, 2-[(5α)-4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-ylidene]hydrazide
CAS Number:
119630-94-3
Molecular Formula:
C26H27N3O4
Molecular Weight:
445.5103
IUPAC Name:
N-[(E)-[(4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ylidene]amino]benzamide
InChI:
InChI=1S/C26H27N3O4/c1-2-13-29-14-12-25-21-17-8-9-19(30)22(21)33-23(25)18(10-11-26(25,32)20(29)15-17)27-28-24(31)16-6-4-3-5-7-16/h2-9,20,23,30,32H,1,10-15H2,(H,28,31)/b27-18+/t20-,23+,25+,26-/m1/s1
InChI Key:
AKXCFAYOTIEFOH-XTNAHFASSA-N
SMILES:
C=CCN1CC[C@@]23[C@@]4([C@H]1Cc1c3c(O[C@H]2C(=NNC(=O)c2ccccc2)CC4)c(cc1)O)O
Properties
Complexity:
841
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
4
Defined Bond Stereocenter Count:
1
Exact Mass:
445.2g/mol
Formal Charge:
0
Heavy Atom Count:
33
Hydrogen Bond Acceptor Count:
6
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
445.519g/mol
Monoisotopic Mass:
445.2g/mol
Rotatable Bond Count:
4
Topological Polar Surface Area:
94.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.5
Literature
| Title | Journal |
|---|---|
| Binding of GTPgamma[35S] is regulated by GDP and receptor activation. Studies with the nociceptin/orphanin FQ receptor. | British journal of pharmacology 20100301 |
| The nociceptin system and hippocampal cognition in mice: a pharmacological and genetic analysis. | Brain research 20091211 |
| Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
| Distinct effects of nociceptin analogs on scopolamine-induced memory impairment in mice. | European journal of pharmacology 20090114 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Has the sun set on kappa3-opioid receptors? | British journal of pharmacology 20060201 |
| Agonist activity of naloxone benzoylhydrazone at recombinant and native opioid receptors. | British journal of pharmacology 20060201 |
| The antinociceptive effect of zolpidem and zopiclone in mice. | Pharmacology, biochemistry, and behavior 20050701 |
| Autoradiography in opioid triple knockout mice reveals opioid and opioid receptor like binding of naloxone benzoylhydrazone. | Neuropharmacology 20050201 |
| G protein activation and cyclic AMP modulation by naloxone benzoylhydrazone in distinct layers of rat olfactory bulb. | British journal of pharmacology 20041101 |
| Reassessment of buprenorphine in conditioned place preference: temporal and pharmacological considerations. | Psychopharmacology 20040201 |
| Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors. | British journal of pharmacology 20040101 |
| Effects of naloxone benzoylhydrazone on native and recombinant nociceptin/orphanin FQ receptors. | Canadian journal of physiology and pharmacology 20020501 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| Potentiation of opioid analgesia in dopamine2 receptor knock-out mice: evidence for a tonically active anti-opioid system. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20011001 |
| Gastric acid secretion by central injection of dynorphin A-(1-17), an endogenous ligand of kappa-opioid receptor, in urethane-anesthetized rats. | Japanese journal of pharmacology 20010901 |
| Pre- and postsynaptic inhibition by nociceptin in guinea pig small intestinal myenteric plexus in vitro. | American journal of physiology. Gastrointestinal and liver physiology 20010701 |
| In vitro inhibitory effects of J-113397 on nociceptin/orphanin FQ-stimulated. | Neuroreport 20010613 |
| Differential antagonism by naloxone benzoylhydrazone of the activation of inward rectifying K+ channels by nociceptin and a mu-opioid in rat periaqueductal grey slices. | Naunyn-Schmiedeberg's archives of pharmacology 20010601 |
| Orphanin FQ/nociceptin and naloxone benzoylhydrazone activate distinct receptors in BE(2)-C human neuroblastoma cells. | Neuroscience letters 20010223 |
| Morphine tolerance and dependence in the nociceptin receptor knockout mice. | Journal of neural transmission (Vienna, Austria : 1996) 20010101 |
| Demonstration of kappa 3-opioid receptors in the SH-SY5Y human neuroblastoma cell line. | Journal of neurochemistry 19950701 |
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