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Home > Sulfanilamide > 1196074-08-4
1196074-08-4 | 4-tert-butyl-N-(6-(2-hydroxyethoxy)-5-(2-Methoxyphenoxy)-2,2'-bipyriMidin-4-yl)benzenesulfonaMide hydrate
CAS No: 1196074-08-4 Catalog No: AG008TCO MDL No:
Product Description
Catalog Number:
AG008TCO
Chemical Name:
4-tert-butyl-N-(6-(2-hydroxyethoxy)-5-(2-Methoxyphenoxy)-2,2'-bipyriMidin-4-yl)benzenesulfonaMide hydrate
CAS Number:
1196074-08-4
Molecular Formula:
C27H30ClN5O6S
Molecular Weight:
588.0750
IUPAC Name:
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]benzenesulfonamide;hydrate
InChI:
InChI=1S/C27H29N5O6S.H2O/c1-27(2,3)18-10-12-19(13-11-18)39(34,35)32-23-22(38-21-9-6-5-8-20(21)36-4)26(37-17-16-33)31-25(30-23)24-28-14-7-15-29-24;/h5-15,33H,16-17H2,1-4H3,(H,30,31,32);1H2
InChI Key:
SXTRWVVIEPWAKM-UHFFFAOYSA-N
SMILES:
OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1.Cl
UNII:
Q326023R30
Properties
Complexity:
839
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
569.194g/mol
Formal Charge:
0
Heavy Atom Count:
40
Hydrogen Bond Acceptor Count:
12
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
569.633g/mol
Monoisotopic Mass:
569.194g/mol
Rotatable Bond Count:
11
Topological Polar Surface Area:
155A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
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|---|---|
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| Acute effects of endothelin receptor antagonists on hepatic hemodynamics of cirrhotic and noncirrhotic rats. | Canadian journal of physiology and pharmacology 20100601 |
| Evaluation of the endothelin receptor antagonists ambrisentan, darusentan, bosentan, and sitaxsentan as substrates and inhibitors of hepatobiliary transporters in sandwich-cultured human hepatocytes. | Canadian journal of physiology and pharmacology 20100601 |
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| Successful bosentan and nonnucleoside reverse transcriptase inhibitor-based therapy in a patient with acquired immunodeficiency syndrome and pulmonary arterial hypertension. | Pharmacotherapy 20100401 |
| Role of endothelin receptors in the control of central nervous system parasitism in Trypanosoma cruzi infection in rats. | Journal of neuroimmunology 20100330 |
| Long-term outcome of systemic sclerosis-associated pulmonary arterial hypertension treated with bosentan as first-line monotherapy followed or not by the addition of prostanoids or sildenafil. | Rheumatology (Oxford, England) 20100301 |
| Effect of the dual endothelin receptor antagonist bosentan on Raynaud's phenomenon secondary to systemic sclerosis: a double-blind prospective, randomized, placebo-controlled pilot study. | Rheumatology (Oxford, England) 20100301 |
| Endothelin 1 contributes to the effect of transforming growth factor beta1 on wound repair and skin fibrosis. | Arthritis and rheumatism 20100301 |
| Endothelin receptors blockade blunts hypoxia-induced increase in PAP in humans. | European journal of clinical investigation 20100301 |
| Hereditary hemorrhagic telangiectasia: rare cause of pulmonary hypertension? | Arquivos brasileiros de cardiologia 20100301 |
| The 6 minute walk in idiopathic pulmonary fibrosis: longitudinal changes and minimum important difference. | Thorax 20100201 |
| Pulmonary hypertension in thoracic surgical patients. | Current opinion in anaesthesiology 20100201 |
| Efficacy, safety and tolerability of bosentan in Chinese patients with pulmonary arterial hypertension. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20100201 |
| The globalization of clinical trials in pulmonary arterial hypertension. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20100201 |
| The Achilles heel of endothelin receptor therapy for pulmonary arterial hypertension. | The European respiratory journal 20100201 |
| [Endothelin receptor antagonists in the new European guidelines on pulmonary hypertension]. | Revue des maladies respiratoires 20100201 |
| [Guidelines for the diagnosis and treatment of pulmonary hypertension]. | Revue des maladies respiratoires 20100201 |
| [Bosenten and sildenafil in the treatment of Eisenmenger syndrome]. | Kardiologia polska 20100201 |
| Improvement of bleomycin-induced pulmonary hypertension and pulmonary fibrosis by the endothelin receptor antagonist Bosentan. | Respiratory physiology & neurobiology 20100131 |
| Renal failure in cirrhosis. | The New England journal of medicine 20100107 |
| Bosentan as a bridge to pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension. | The Journal of thoracic and cardiovascular surgery 20100101 |
| Quality of life and dyspnoea in patients treated with bosentan for idiopathic pulmonary fibrosis (BUILD-1). | The European respiratory journal 20100101 |
| Potential of endothelin-1 and vasopressin antagonists for the treatment of congestive heart failure. | Heart failure reviews 20100101 |
| Effects of an endothelin receptor antagonist on a model of hypertensive retinopathy. | Ophthalmic research 20100101 |
| Liver impairment after concomitant administration of bosentan and clarithromycin in systemic sclerosis. | Joint, bone, spine : revue du rhumatisme 20100101 |
| Bosentan: in pediatric patients with pulmonary arterial hypertension. | Paediatric drugs 20100101 |
| Pulmonary arterial hypertension in connective tissue diseases. | Cardiology in review 20100101 |
| Hemodynamics in pulmonary arterial hypertension (PAH): do they explain long-term clinical outcomes with PAH-specific therapy? | BMC cardiovascular disorders 20100101 |
| Warfarin and bosentan interaction in a patient with pulmonary hypertension secondary to bilateral pulmonary emboli. | Clinical therapeutics 20100101 |
| Oral Therapies for the treatment of pulmonary arterial hypertension: a population-based cost-minimization analysis. | Applied health economics and health policy 20100101 |
| A randomized, double-blind, placebo-controlled study of high-dose bosentan in patients with stage IV metastatic melanoma receiving first-line dacarbazine chemotherapy. | Molecular cancer 20100101 |
| Mutual pharmacokinetic interactions between bosentan and lopinavir/ritonavir in healthy participants. | Antiviral therapy 20100101 |
| Effects of a rehabilitation program on skeletal muscle function in idiopathic pulmonary arterial hypertension. | Journal of cardiopulmonary rehabilitation and prevention 20100101 |
| First report of the successful use of bosentan in refractory vasospastic angina. | Cardiology 20100101 |
| Advances in the treatment of Raynaud's phenomenon. | Vascular health and risk management 20100101 |
| Evaluation of treatment with bosentan in patients with carcinoid heart disease: single center study. | Onkologie 20100101 |
| Treatment patterns and resource utilization and costs among patients with pulmonary arterial hypertension in the United States. | Journal of medical economics 20100101 |
| Post-operative management of endarterectomy. | Annals of cardiac anaesthesia 20100101 |
| Bosentan ameliorated exercise-induced pulmonary arterial hypertension complicated with systemic sclerosis. | Internal medicine (Tokyo, Japan) 20100101 |
| A case of curable pulmonary hypertension. | Archives of cardiovascular diseases 20100101 |
| Eisenmenger syndrome due to a large ductus arteriosus. | Archives of cardiovascular diseases 20100101 |
| Treatment of pulmonary hypertension in patients with connective tissue disease and interstitial lung disease. | Canadian respiratory journal 20100101 |
| Bosentan treatment for Raynauds phenomenon and skin fibrosis in patients with Systemic Sclerosis and pulmonary arterial hypertension: an open-label, observational, retrospective study. | International journal of immunopathology and pharmacology 20100101 |
| [Using nonselective endothelin receptor antagonist in idiopathic pulmonary hypertension]. | Terapevticheskii arkhiv 20100101 |
| Endothelin receptor antagonists for pulmonary hypertension in adult patients with sickle cell disease. | British journal of haematology 20091201 |
| Bosentan for chronic thromboembolic pulmonary hypertension. | Expert review of cardiovascular therapy 20091201 |
| Pharmacokinetic and clinical profile of a novel formulation of bosentan in children with pulmonary arterial hypertension: the FUTURE-1 study. | British journal of clinical pharmacology 20091201 |
| Eisenmenger syndrome and juvenile rheumatoid arthritis--a case of double diagnosis. | Kardiologia polska 20091201 |
| [Eisenmenger syndrome. Specific treatments]. | Presse medicale (Paris, France : 1983) 20091201 |
| Outcome of pulmonary hypertension subjects transitioned from intravenous prostacyclin to oral bosentan. | Respiratory medicine 20091101 |
| Acute hemodynamic effects of single-dose sildenafil when added to established bosentan therapy in patients with pulmonary arterial hypertension: results of the COMPASS-1 study. | Journal of clinical pharmacology 20091101 |
| Goal-oriented therapy in pulmonary veno-occlusive disease: a word of caution. | The European respiratory journal 20091101 |
| Unilateral absence of a left pulmonary artery: successful therapeutic response to a combination of bosentan and warfarin. | Circulation. Cardiovascular imaging 20091101 |
| Lipopolysaccharide alters vasodilation to atrial natriuretic peptide via nitric oxide and endothelin-1: time-dependent effects. | European journal of pharmacology 20091025 |
| Low-dose combination therapy of severe digital ulcers in diffuse progressive systemic sclerosis with the endothelin-1 receptor antagonist bosentan and the phosphodiesterase V inhibitor sildenafil. | Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20091001 |
| Successful treatment of persistent pulmonary hypertension of the newborn with bosentan. | Acta paediatrica (Oslo, Norway : 1992) 20091001 |
| [Effectiveness of bosentan in the management of Latin American patients diagnosed with pulmonary arterial hypertension]. | Archivos de bronconeumologia 20091001 |
| Bosentan: a review of its use in the management of digital ulcers associated with systemic sclerosis. | Drugs 20091001 |
| Clinical and cost-effectiveness of epoprostenol, iloprost, bosentan, sitaxentan and sildenafil for pulmonary arterial hypertension within their licensed indications: a systematic review and economic evaluation. | Health technology assessment (Winchester, England) 20091001 |
| Bosentan reduces oxidative burst in acid aspiration-induced lung injury in rats. | Injury 20090901 |
| Mechanisms responsible for the altered pharmacokinetics of bosentan: analysis utilizing rats with bile duct ligation-induced liver dysfunction. | Biopharmaceutics & drug disposition 20090901 |
| Long-term bosentan treatment of complex congenital heart disease and Eisenmenger's syndrome. | Revista espanola de cardiologia 20090901 |
| Chronic thromboembolic pulmonary hypertension as a cause of dyspnoea in an older patient with a complex history. | European respiratory review : an official journal of the European Respiratory Society 20090901 |
| [Outcome of oral bosentan in children with congenital heart disease associated pulmonary arterial hypertension]. | Zhonghua yi xue za zhi 20090811 |
| The effect of bosentan in patients with a failing Fontan circulation. | Cardiology in the young 20090801 |
| [Endothelin-receptor antagonists in therapy of pulmonary arterial hypertension]. | Deutsche medizinische Wochenschrift (1946) 20090801 |
| Bosentan increases serum IL-12 levels in systemic sclerosis patients with pulmonary arterial hypertension. | Journal of dermatological science 20090701 |
| No effects of bosentan on microvasculature in patients with limited cutaneous systemic sclerosis. | Clinical rheumatology 20090701 |
| The ischemic metabolite lysophosphatidylcholine increases rat coronary arterial tone by endothelium-dependent mechanisms. | Journal of molecular and cellular cardiology 20090701 |
| Endothelin receptor blockade combined with phosphodiesterase-5 inhibition increases right ventricular mitochondrial capacity in pulmonary arterial hypertension. | American journal of physiology. Heart and circulatory physiology 20090701 |
| Pulmonary arterial hypertension associated with interferon beta treatment for multiple sclerosis: a case report. | Multiple sclerosis (Houndmills, Basingstoke, England) 20090701 |
| Bosentan for digital ulcers in patients with systemic sclerosis: a prospective 3-year followup study. | The Journal of rheumatology 20090701 |
| Tadalafil therapy for pulmonary arterial hypertension. | Circulation 20090609 |
| Involvement of endothelin-1 in habitual exercise-induced increase in arterial compliance. | Acta physiologica (Oxford, England) 20090601 |
| Treatment of sarcoidosis-associated pulmonary hypertension. A two-center experience. | Chest 20090601 |
| A review of STRIDE-2 and STRIDE-2X: the case for selective endothelin receptor blockade. | European journal of clinical investigation 20090601 |
| Up-regulation of endothelin type a receptor in human and rat radiation proctitis: preclinical therapeutic approach with endothelin receptor blockade. | International journal of radiation oncology, biology, physics 20090601 |
| Clinical significance of plasma endothelin-1 level after bosentan administration in pulmonary arterial hypertension. | Journal of cardiology 20090601 |
| Digital ulcers: overt vascular disease in systemic sclerosis. | Rheumatology (Oxford, England) 20090601 |
| Pulmonary arterial hypertension: the most devastating vascular complication of systemic sclerosis. | Rheumatology (Oxford, England) 20090601 |
| Vasculopathy and pulmonary arterial hypertension. | Rheumatology (Oxford, England) 20090601 |
| Small-molecule endothelin receptor antagonists: a review of patenting activity across therapeutic areas. | IDrugs : the investigational drugs journal 20090601 |
| Portopulmonary hypertension: imatinib as a novel treatment and the Emory experience with this condition. | Transplantation proceedings 20090601 |
| Improved myocardial perfusion preceding clinical response on bosentan treatment for coronary vasospasm. | Acta cardiologica 20090601 |
| Sarcoidosis-associated pulmonary hypertension: a role for endothelin receptor antagonists? | Therapeutic advances in respiratory disease 20090601 |
| Down patients with Eisenmenger syndrome: is bosentan treatment an option? | International journal of cardiology 20090529 |
| CCL3/MIP-1 alpha is not involved in the LPS-induced fever and its pyrogenic activity depends on CRF. | Brain research 20090507 |
| Effects of bosentan on the skin lesions: an observational study from a single center in Japan. | Rheumatology international 20090501 |
| Duration of right ventricular contraction predicts the efficacy of bosentan treatment in patients with pulmonary hypertension. | European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology 20090501 |
| Clinical practice: pulmonary hypertension in children. | European journal of pediatrics 20090501 |
| Bosentan decreases pulmonary vascular resistance and improves exercise capacity in acute hypoxia. | Chest 20090501 |
| Endothelin-receptor antagonist/N-acetylcysteine combination in type 1 hepatorenal syndrome. | Journal of hepatology 20090501 |
| Effect of bosentan on exercise capacity and quality of life in adults with pulmonary arterial hypertension associated with congenital heart disease with and without Down's syndrome. | The American journal of cardiology 20090501 |
| Severe pulmonary hypertension and adenotonsillectomy in a child with Trisomy-21 and obstructive sleep apnea. | Paediatric anaesthesia 20090501 |
| Major role for hypoxia inducible factor-1 and the endothelin system in promoting myocardial infarction and hypertension in an animal model of obstructive sleep apnea. | Journal of the American College of Cardiology 20090414 |
| Effect of bosentan on plasma markers of endothelial cell activity in patients with secondary pulmonary hypertension related to connective tissue diseases. | The Journal of rheumatology 20090401 |
| Myoendothelial coupling in the mesenteric arterial bed; segmental differences and interplay between nitric oxide and endothelin-1. | British journal of pharmacology 20090401 |
| Bosentan in pediatric patients with pulmonary arterial hypertension. | Current vascular pharmacology 20090401 |
| Substrate-specific pharmacokinetic interaction between endothelin receptor antagonists and phosphodiesterase-5 inhibitors--assembling the clues. | British journal of clinical pharmacology 20090401 |
| Bosentan enhances viral load via endothelin-1 receptor type-A-mediated p38 mitogen-activated protein kinase activation while improving cardiac function during coxsackievirus-induced myocarditis. | Circulation research 20090327 |
| Eisenmenger syndrome a clinical perspective in a new therapeutic era of pulmonary arterial hypertension. | Journal of the American College of Cardiology 20090303 |
| Delayed hypersensitivity to bosentan. | Allergy 20090301 |
| [Therapy of mild, but symptomatic pulmonary hypertension]. | Der Internist 20090301 |
| Atrial septal defect repair after a 10-month treatment with bosentan in a patient with severe pulmonary arterial hypertension: a case report. | The Journal of thoracic and cardiovascular surgery 20090301 |
| Severe hepatotoxicity in a patient on bosentan upon addition of methotrexate: reversible with resumption of methotrexate without bosentan. | Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 20090301 |
| Endothelin receptor antagonist therapy in congenital heart disease with shunt-associated pulmonary arterial hypertension: a qualitative systematic review. | The Canadian journal of cardiology 20090301 |
| Addition of prostanoids in pulmonary hypertension deteriorating on oral therapy. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20090301 |
| Prophylactic bosentan does not improve exercise capacity or lower pulmonary artery systolic pressure at high altitude. | Respiratory physiology & neurobiology 20090227 |
| Synergistic growth inhibitory effects of the dual endothelin-1 receptor antagonist bosentan on pancreatic stellate and cancer cells. | Digestive diseases and sciences 20090201 |
| Treatment and survival in children with pulmonary arterial hypertension: the UK Pulmonary Hypertension Service for Children 2001-2006. | Heart (British Cardiac Society) 20090201 |
| [Pulmonary arterial hypertension related to systemic sclerosis in 2008]. | Journal des maladies vasculaires 20090201 |
| Portopulmonary hypertension. | Current gastroenterology reports 20090201 |
| Survival in pulmonary hypertension associated with the scleroderma spectrum of diseases: impact of interstitial lung disease. | Arthritis and rheumatism 20090201 |
| Pulmonary hypertension therapy and COPD: still many questions to be answered. | The European respiratory journal 20090201 |
| Pulmonary hypertension therapy and COPD: still many questions to be answered. | The European respiratory journal 20090201 |
| Pulmonary hypertension therapy and COPD: still many questions to be answered. | The European respiratory journal 20090201 |
| Effect of bosentan upon pulmonary hypertension in chronic obstructive pulmonary disease. | Therapeutic advances in respiratory disease 20090201 |
| N-terminal pro-brain natriuretic peptide in systemic sclerosis related pulmonary arterial hypertension under bosentan treatment. | Rheumatology international 20090101 |
| Effect of dual endothelin receptor blockade on ocular blood flow in patients with glaucoma and healthy subjects. | Investigative ophthalmology & visual science 20090101 |
| Long-term effects of bosentan in patients with HIV-associated pulmonary arterial hypertension. | The European respiratory journal 20090101 |
| Ambrisentan therapy in patients with pulmonary arterial hypertension who discontinued bosentan or sitaxsentan due to liver function test abnormalities. | Chest 20090101 |
| [Pulmonary hypertension in a patient on chronic hemodialysis]. | Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20090101 |
| The remodeling of connexin in the hypertrophied right ventricular in pulmonary arterial hypertension and the effect of a dual ET receptor antagonist (bosentan). | Pathology, research and practice 20090101 |
| Bosentan for patients with chronic thromboembolic pulmonary hypertension. | European journal of internal medicine 20090101 |
| Portopulmonary hypertension associated with congenital absence of the portal vein treated with bosentan. | Internal medicine (Tokyo, Japan) 20090101 |
| [Potential role of endothelin in patients with acute pulmonary embolism and chronic thromboembolic pulmonary hypertension]. | Pneumonologia i alergologia polska 20090101 |
| Patients with pulmonary hypertension related to congenital systemic-to-pulmonary shunts are characterized by inflammation involving endothelial cell activation and platelet-mediated inflammation. | Congenital heart disease 20090101 |
| Systemic lupus erythematosus, complicated with refractory skin ulcers, treated successfully with bosentan. | Modern rheumatology 20090101 |
| Oral therapies for the treatment of pulmonary arterial hypertension: a population-based cost-minimization analysis. | Applied health economics and health policy 20090101 |
| The cost-effectiveness of bosentan in the United Kingdom for patients with pulmonary arterial hypertension of WHO functional class III. | Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20090101 |
| Endothelin receptor blockade does not affect blood pressure or angiotensin II levels in CYP1A1-Ren-2 transgenic rats with acutely induced hypertension. | Vascular pharmacology 20090101 |
| Bosentan in the treatment of pulmonary arterial hypertension with the focus on the mildly symptomatic patient. | Vascular health and risk management 20090101 |
| Bosentan: a review of its use in the management of mildly symptomatic pulmonary arterial hypertension. | American journal of cardiovascular drugs : drugs, devices, and other interventions 20090101 |
| Graves' disease associated with primary systemic sclerosis. | Orbit (Amsterdam, Netherlands) 20090101 |
| An atypical presentation of liver enzyme elevation resulting from bosentan use. | Canadian respiratory journal 20090101 |
| Selective endothelin A-receptor blockade attenuates coronary microvascular dysfunction after coronary stenting in patients with type 2 diabetes. | Vascular health and risk management 20090101 |
| Novel therapies in sickle cell disease. | Hematology. American Society of Hematology. Education Program 20090101 |
| Endothelin receptor antagonist and airway dysfunction in pulmonary arterial hypertension. | Respiratory research 20090101 |
| End-organ damage in hypertensive transgenic Ren-2 rats: influence of early and late endothelin receptor blockade. | Physiological research 20090101 |
| Bosentan for treatment of inoperable chronic thromboembolic pulmonary hypertension: BENEFiT (Bosentan Effects in iNopErable Forms of chronIc Thromboembolic pulmonary hypertension), a randomized, placebo-controlled trial. | Journal of the American College of Cardiology 20081216 |
| The responsiveness and validity of the CAMPHOR Utility Index. | The European respiratory journal 20081201 |
| Successful treatment with bosentan of non-digital skin ulcers in severe scleroderma. | Annals of the rheumatic diseases 20081201 |
| Role of endogenous endothelin in endothelial dysfunction in murine model of systemic sclerosis: tight skin mice 1. | Fundamental & clinical pharmacology 20081201 |
| Venous endotelin-1 (ET-1) and brain natriuretic peptide (BNP) plasma levels during 6-month bosentan treatment for pulmonary arterial hypertension. | Regulatory peptides 20081129 |
| Bosentan in mild pulmonary hypertension. | Lancet (London, England) 20081115 |
| Bosentan in mild pulmonary hypertension. | Lancet (London, England) 20081115 |
| Bosentan: a rapidly expanding role in the management of cardio-thoracic diseases. | Rheumatology international 20081101 |
| Treatment of pulmonary hypertension in children with chronic lung disease with newer oral therapies. | Pediatric cardiology 20081101 |
| Modeling, prediction, and in vitro in vivo correlation of CYP3A4 induction. | Drug metabolism and disposition: the biological fate of chemicals 20081101 |
| Successful bosentan treatment of critical ischaemia induced by vasculitis in an SCLE patient. | Rheumatology (Oxford, England) 20081101 |
| Pulmonary arterial hypertension in adults with congenital heart disease: distinct differences from other causes of pulmonary arterial hypertension and management implications. | Current opinion in cardiology 20081101 |
| Bosentan for idiopathic pulmonary fibrosis. | Current opinion in investigational drugs (London, England : 2000) 20081101 |
| [Endothelin receptor antagonist]. | Nihon rinsho. Japanese journal of clinical medicine 20081101 |
| [Remarkable response of bosentan, an endothelin receptor antagonist, for a patient with Eisenmenger syndrome]. | Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20081010 |
| Endothelin and scleroderma lung disease. | Rheumatology (Oxford, England) 20081001 |
| Digital ulcers and outcomes assessment in scleroderma. | Rheumatology (Oxford, England) 20081001 |
| GSK-3beta in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanism. | The Journal of clinical investigation 20081001 |
| [Specific drugs for the treatment of pulmonary arterial hypertension - current status]. | Deutsche medizinische Wochenschrift (1946) 20081001 |
| [Combination therapy in patients with pulmonary arterial hypertension]. | Deutsche medizinische Wochenschrift (1946) 20081001 |
| [Update in pulmonary hypertension associated with connective tissue diseases - a systematic literature review]. | Deutsche medizinische Wochenschrift (1946) 20081001 |
| Salt-induced cardiac hypertrophy is independent of blood pressure and endothelin in obese, heart failure-prone SHHF rats. | Clinical and experimental hypertension (New York, N.Y. : 1993) 20081001 |
| Platelet-derived growth factor inhibition--a new treatment of pulmonary hypertension in congenital diaphragmatic hernia? | Journal of pediatric surgery 20081001 |
| The drug-drug interaction potential of rifampicin. | Clinical therapeutics 20081001 |
| Optimizing endothelin receptor antagonist use in the management of pulmonary arterial hypertension. | Vascular health and risk management 20081001 |
| Long-term effects of bosentan on quality of life, survival, safety and tolerability in pulmonary arterial hypertension related to connective tissue diseases. | Annals of the rheumatic diseases 20080901 |
| A randomised, controlled trial of bosentan in severe COPD. | The European respiratory journal 20080901 |
| Endothelins modulate inflammatory reaction in zymosan-induced arthritis: participation of LTB4, TNF-alpha, and CXCL-1. | Journal of leukocyte biology 20080901 |
| Efficacy of the endothelin receptor blocker bosentan for refractory sickle cell leg ulcers. | British journal of haematology 20080901 |
| Targeting the endothelin pathway in the idiopathic pulmonary fibrosis: the role of bosentan. | Expert opinion on therapeutic targets 20080901 |
| Bosentan therapy in patients with pulmonary arterial hypertension: the relationship between improvements in 6 minute walk distance and quality of life. | Respirology (Carlton, Vic.) 20080901 |
| Chronic stable angina pectoris. | Disease-a-month : DM 20080901 |
| Treating pulmonary hypertension in COPD: where do we start? | The European respiratory journal 20080901 |
| Influence of endothelin 1 receptor inhibition on functional, structural and molecular changes in the rat heart after irradiation. | Radiation research 20080901 |
| Dramatic functional improvement following bariatric surgery in a patient with pulmonary arterial hypertension and morbid obesity. | Chest 20080901 |
| HIV-related pulmonary arterial hypertension: clinical presentation and management. | AIDS (London, England) 20080901 |
| [Effects of bosentan in treatment of pulmonary arterial hypertension: a pilot study of 21 patients]. | Zhonghua yi xue za zhi 20080805 |
| Bosentan regulates the expression of adhesion molecules on circulating T cells and serum soluble adhesion molecules in systemic sclerosis-associated pulmonary arterial hypertension. | Annals of the rheumatic diseases 20080801 |
| Safety experience with bosentan in 146 children 2-11 years old with pulmonary arterial hypertension: results from the European Postmarketing Surveillance program. | Pediatric research 20080801 |
| Changes in exercise haemodynamics during treatment in pulmonary arterial hypertension. | The European respiratory journal 20080801 |
| The effects of endothelin receptor blockade by bosentan on the healing of a bowel anastomosis in an experimental Crohn's disease model. | Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20080801 |
| Late treatment with angiotensin-converting enzyme inhibitors plus endothelin receptor antagonists ameliorates rat tracheal allograft rejection. | Transplant international : official journal of the European Society for Organ Transplantation 20080801 |
| Inhibition of endothelin receptors in the treatment of pulmonary arterial hypertension: does selectivity matter? | European heart journal 20080801 |
| [A case of severe pulmonary hypertension associated with COPD treated with epoprostenol]. | Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20080801 |
| A case report of successful treatment with immunoadsorption onto protein A in mixed connective tissue disease in childhood. | Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 20080801 |
| Vaso-active therapy can improve 6-min walk distance in patients with pulmonary hypertension and fibrotic interstitial lung disease. | Respiratory medicine 20080701 |
| Increased cardiac sympathetic drive and reduced vagal modulation following endothelin receptor antagonism in healthy conscious rats. | Clinical and experimental pharmacology & physiology 20080701 |
| Treprostinil-based therapy in the treatment of moderate-to-severe pulmonary arterial hypertension: long-term efficacy and combination with bosentan. | Chest 20080701 |
| Additional effects of bosentan in patients with idiopathic pulmonary arterial hypertension already treated with high-dose epoprostenol. | Circulation journal : official journal of the Japanese Circulation Society 20080701 |
| Successful treatment with bosentan for refractory digital ulcers in a patient with systemic lupus erythematosus. | The Journal of dermatology 20080701 |
| Longer-term bosentan therapy improves functional capacity in Eisenmenger syndrome: results of the BREATHE-5 open-label extension study. | International journal of cardiology 20080623 |
| Endothelin-receptor antagonism: the future is bright. | Lancet (London, England) 20080621 |
| Treatment of patients with mildly symptomatic pulmonary arterial hypertension with bosentan (EARLY study): a double-blind, randomised controlled trial. | Lancet (London, England) 20080621 |
| LPS abolishes extrasplenic vasoconstriction to atrial natriuretic peptide: the role of NO and endothelin 1. | Shock (Augusta, Ga.) 20080601 |
| Cardiac expression patterns of endothelin-converting enzyme (ECE): implications for conduction system development. | Developmental dynamics : an official publication of the American Association of Anatomists 20080601 |
| Changes in right ventricular structure and function assessed using cardiac magnetic resonance imaging in bosentan-treated patients with pulmonary arterial hypertension. | The American journal of cardiology 20080601 |
| Late complete heart block in an adult patient undergoing percutaneous ventricular septal defect closure. | The Journal of invasive cardiology 20080601 |
| Bosentan in systemic sclerosis. | Drugs of today (Barcelona, Spain : 1998) 20080601 |
| N-terminal pro-BNP in sclerodermic patients on bosentan therapy for PAH. | Rheumatology international 20080501 |
| N-terminal probrain natriuretic peptide as a biochemical marker in the evaluation of bosentan treatment in systemic-sclerosis-related pulmonary arterial hypertension. | Clinical rheumatology 20080501 |
| Long-term experience after transition from parenteral prostanoids to oral agents in patients with pulmonary hypertension. | Respiratory medicine 20080501 |
| Pharmacokinetic interaction between tadalafil and bosentan in healthy male subjects. | Journal of clinical pharmacology 20080501 |
| Endothelin receptor antagonism prevents hypoxia-induced mortality and morbidity in a mouse model of sickle-cell disease. | The Journal of clinical investigation 20080501 |
| Treatment for Raynaud's: beyond calcium channel blockers. | Journal of drugs in dermatology : JDD 20080501 |
| Persistent pulmonary hypertension of the newborn with transposition of the great arteries: successful treatment with bosentan. | European journal of pediatrics 20080401 |
| [Treatment of pulmonary arterial hypertension by endothelin receptor antagonists in 2008]. | La Revue de medecine interne 20080401 |
| [Digital ulcers in systemic sclerosis]. | Presse medicale (Paris, France : 1983) 20080401 |
| Long-term experience of bosentan for treating ulcers and healed ulcers in systemic sclerosis patients. | Rheumatology (Oxford, England) 20080401 |
| Effect of endothelin receptor antagonists on ventricular susceptibility in postinfarcted rats. | American journal of physiology. Heart and circulatory physiology 20080401 |
| [Long-term therapy with endothelin-1 antagonist for pulmonary hypertension secondary to systemic sclerosis]. | Harefuah 20080401 |
| Physiological concentration of 17beta-estradiol on sympathetic reinnervation in ovariectomized infarcted rats. | Endocrinology 20080301 |
| Effects of nonselective endothelin-1 receptor antagonism on cardiac mast cell-mediated ventricular remodeling in rats. | American journal of physiology. Heart and circulatory physiology 20080301 |
| Diagnosis of pulmonary arterial hypertension in a patient with systemic sclerosis. | Nature clinical practice. Rheumatology 20080301 |
| Safety and efficacy of combined use of sildenafil, bosentan, and iloprost before and after liver transplantation in severe portopulmonary hypertension. | Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20080301 |
| Effects of dual endothelin receptor blockade on sympathetic activation and arrhythmogenesis during acute myocardial infarction in rats. | European journal of pharmacology 20080202 |
| Direct cardiac actions of erythropoietin (EPO): effects on cardiac contractility, BNP secretion and ischaemia/reperfusion injury. | Clinical science (London, England : 1979) 20080201 |
| Pulmonary hypertension: basic concepts and practical management. | The European respiratory journal 20080201 |
| Endothelin receptor antagonists in pulmonary arterial hypertension. | The European respiratory journal 20080201 |
| Advances in diagnosis and treatment in patients with pulmonary arterial hypertension. | Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20080201 |
| A retrospective study of bosentan in pulmonary arterial hypertension associated with congenital heart disease. | Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20080201 |
| Successful treatment of sarcoidosis-associated pulmonary hypertension with bosentan. | Respiration; international review of thoracic diseases 20080101 |
| Clinical and hemodynamic effects of bosentan dose optimization in symptomatic heart failure patients with severe systolic dysfunction, associated with secondary pulmonary hypertension--a multi-center randomized study. | Cardiology 20080101 |
| BUILD-1: a randomized placebo-controlled trial of bosentan in idiopathic pulmonary fibrosis. | American journal of respiratory and critical care medicine 20080101 |
| Mutual pharmacokinetic interactions between steady-state bosentan and sildenafil. | European journal of clinical pharmacology 20080101 |
| Current status of bosentan for treatment of pulmonary hypertension. | Annals of cardiac anaesthesia 20080101 |
| Sildenafil for pulmonary hypertension: dose-dependent improvement in exercise performance. | Pulmonary pharmacology & therapeutics 20080101 |
| Inflammatory responses after endothelin B (ETB) receptor activation in human monocytes: new evidence for beneficial anti-inflammatory potency of ETB-receptor antagonism. | Pulmonary pharmacology & therapeutics 20080101 |
| Treatment of severe pulmonary hypertension secondary to scleroderma: a three-drug approach. | Internal medicine (Tokyo, Japan) 20080101 |
| Role of iloprost and bosentan in pulmonary arterial hypertension. | Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria 20080101 |
| Severe liver dysfunction due to bosentan in a patient with mixed connective tissue disease. | European journal of dermatology : EJD 20080101 |
| Endothelin receptor antagonists for pulmonary arterial hypertension: rationale and place in therapy. | American journal of cardiovascular drugs : drugs, devices, and other interventions 20080101 |
| Hidden hazards of Bosentan therapy in pulmonary hypertension. | Annals of cardiac anaesthesia 20080101 |
| Bosentan for the treatment of portopulmonary hypertension. | Annals of cardiac anaesthesia 20080101 |
| Effects of selective and unselective endothelin-receptor antagonists on prostacyclin synthase gene expression in experimental pulmonary hypertension. | Scandinavian journal of clinical and laboratory investigation 20080101 |
| Endothelin receptor antagonism: role in the treatment of pulmonary arterial hypertension related to scleroderma. | Drugs 20080101 |
| Current pharmacological treatment of pulmonary arterial hypertension. | Current clinical pharmacology 20080101 |
| Successful switch from inhaler iloprost to treatment in a patient who initially presented with pulmonary arterial hypertension and diagnosed as SLE. | Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria 20080101 |
| Endothelin receptor antagonists improve exercise tolerance and oxygen saturations in patients with Eisenmenger syndrome and congenital heart defects. | Texas Heart Institute journal 20080101 |
| Efficacy of Bosentan in treatment of refractory sclerodermic bone prominences skin ulcers. | La Clinica terapeutica 20080101 |
| Effect of early bosentan administration on the development of esophageal varices in cirrhotic rats: experimental study in Wistar rats. | Journal of gastroenterology 20080101 |
| Addition of sildenafil in patients with pulmonary arterial hypertension with inadequate response to bosentan monotherapy. | Canadian respiratory journal 20080101 |
| Experience with inhaled iloprost and bosentan in portopulmonary hypertension. | The European respiratory journal 20071201 |
| [The treatment of idiopathic pulmonary artery hypertension and its relation to systemic scleroderma]. | La Revue de medecine interne 20071201 |
| Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts. | Arthritis and rheumatism 20071201 |
| Caring for the orphan's orphan: treatment of patients with portopulmonary hypertension. | The European respiratory journal 20071201 |
| Endothelin receptor antagonists in cancer therapy. | Cancer investigation 20071201 |
| Bosentan treatment in an adult with pulmonary hypertension due to patent ductus arteriosus permits surgical repair. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20071201 |
| Review of bosentan in the management of pulmonary arterial hypertension. | Vascular health and risk management 20071201 |
| [Bosentan and chronic thromboembolic pulmonary hypertension]. | Medicina clinica 20071103 |
| Complex multidrug therapy in a patient with pulmonary hypertension before and after orthotopic heart transplantation. A case report. | Journal of cardiovascular medicine (Hagerstown, Md.) 20071101 |
| Selective and mixed endothelin receptor antagonism in cardiovascular disease. | Trends in pharmacological sciences 20071101 |
| The endothelin receptor blocker bosentan inhibits doxorubicin-induced cardiomyopathy. | Cancer research 20071101 |
| Effect of bosentan on the production of proinflammatory cytokines in a rat model of emphysema. | Experimental & molecular medicine 20071031 |
| Bosentan therapy for chronic thromboembolic pulmonary hypertension. A national open label study assessing the effect of Bosentan on haemodynamics, exercise capacity, quality of life, safety and tolerability in patients with chronic thromboembolic pulmonary hypertension (BOCTEPH-Study). | Swiss medical weekly 20071020 |
| The importance of endothelin-1 for vascular dysfunction in cardiovascular disease. | Cardiovascular research 20071001 |
| Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts. | Matrix biology : journal of the International Society for Matrix Biology 20071001 |
| Bosentan therapy for patients with severe Raynaud's phenomenon in systemic sclerosis. | Annals of the rheumatic diseases 20071001 |
| Long-term effect of bosentan in adults versus children with pulmonary arterial hypertension associated with systemic-to-pulmonary shunt: does the beneficial effect persist? | American heart journal 20071001 |
| Severe pulmonary hypertension due to chronic echinococcal pulmonary emboli treated with targeted pulmonary vascular therapy and hepatic resection. | Chest 20071001 |
| Bosentan and losartan ameliorate acute renal failure associated with mild but not strong NO blockade. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20070901 |
| Survival of patients with idiopathic pulmonary arterial hypertension after listing for transplantation: impact of iloprost and bosentan treatment. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20070901 |
| [Two patients with Eisenmenger syndrome treated with novel agents that target vasodilation of the pulmonary capillary bed]. | Nederlands tijdschrift voor geneeskunde 20070811 |
| Effect of endothelin-1 in esophageal squamous cell carcinoma invasion and its correlation with cathepsin B. | World journal of gastroenterology 20070807 |
| Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil. | Drug metabolism and disposition: the biological fate of chemicals 20070801 |
| Results of European post-marketing surveillance of bosentan in pulmonary hypertension. | The European respiratory journal 20070801 |
| Successful treatment with bosentan for severe digital ischaemia in limited cutaneous systemic sclerosis. | Annals of the rheumatic diseases 20070801 |
| Long-term safety, tolerability and efficacy of bosentan in adults with pulmonary arterial hypertension associated with congenital heart disease. | Heart (British Cardiac Society) 20070801 |
| [Warfarin-bosentan interaction. Risk of big INR changes]. | Lakartidningen 20070801 |
| Long-term outcome and effects of oral bosentan therapy in Taiwanese patients with advanced idiopathic pulmonary arterial hypertension. | Respiratory medicine 20070701 |
| Right ventricular diastolic dysfunction and the acute effects of sildenafil in pulmonary hypertension patients. | Chest 20070701 |
| A phase II study of bosentan, a dual endothelin receptor antagonist, as monotherapy in patients with stage IV metastatic melanoma. | Investigational new drugs 20070601 |
| Differential inhibition of rat and human Na+-dependent taurocholate cotransporting polypeptide (NTCP/SLC10A1)by bosentan: a mechanism for species differences in hepatotoxicity. | The Journal of pharmacology and experimental therapeutics 20070601 |
| Treatment of patients with Eisenmenger's syndrome with Bosentan. | Cardiology in the young 20070601 |
| Improvement of vascular endothelial function using the oral endothelin receptor antagonist bosentan in patients with systemic sclerosis. | Arthritis and rheumatism 20070601 |
| [An initial experience of endotherine-1 dual-receptor blockade in the treatment of sustained pulmonary hypertension early after congenital cardiac surgery in infancy]. | Kyobu geka. The Japanese journal of thoracic surgery 20070601 |
| [Bosentan for treatment of heart failure]. | Nihon rinsho. Japanese journal of clinical medicine 20070528 |
| Long term effects of bosentan treatment in adult patients with pulmonary arterial hypertension related to congenital heart disease (Eisenmenger physiology): safety, tolerability, clinical, and haemodynamic effect. | Heart (British Cardiac Society) 20070501 |
| The impact of treatment of portopulmonary hypertension on survival following liver transplantation. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20070501 |
| Polyarteritis nodosa resistant to conventional treatment in a pediatric patient. | The Annals of pharmacotherapy 20070501 |
| Management of pulmonary arterial hypertension with a focus on combination therapies. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20070501 |
| [Treatment of a leg ulcer with bosentan in a female patient with progressive systemic scleroderma]. | Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20070501 |
| Endothelin-1 accentuates the proatherosclerotic effects associated with C-reactive protein. | The Journal of thoracic and cardiovascular surgery 20070501 |
| Does endothelin play a role in chemoreception during acute hypoxia in normal men? | Chest 20070501 |
| Effect of the endothelin receptor antagonist bosentan on chronic hypoxia-induced morphological and physiological changes in rat carotid body. | American journal of physiology. Lung cellular and molecular physiology 20070501 |
| Combined endothelin receptor antagonist and transcatheter interventional therapy of patent ductus arteriosus with severe pulmonary artery hypertension. | International journal of cardiology 20070404 |
| Therapeutic profile of orphan medicines. | Pharmacoepidemiology and drug safety 20070401 |
| Safety and tolerability of bosentan in idiopathic pulmonary fibrosis: an open label study. | The European respiratory journal 20070401 |
| Long-term follow-up after conversion from intravenous epoprostenol to oral therapy with bosentan or sildenafil in 13 patients with pulmonary arterial hypertension. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20070401 |
| The effect of nonsteroidal anti-inflammatory drugs on rat gastric mucosa. The role of endothelin. | Saudi medical journal 20070401 |
| [Treatment with sildenafil, bosentan, or both in children and young people with idiopathic pulmonary arterial hypertension and Eisenmenger's syndrome]. | Revista espanola de cardiologia 20070401 |
| Long-term oral bosentan treatment in patients with pulmonary arterial hypertension related to congenital heart disease: a 2-year study. | Heart (British Cardiac Society) 20070301 |
| Addition of sildenafil to bosentan monotherapy in pulmonary arterial hypertension. | The European respiratory journal 20070301 |
| Inhibitory and inductive effects of rifampin on the pharmacokinetics of bosentan in healthy subjects. | Clinical pharmacology and therapeutics 20070301 |
| Effect of bosentan on plasma endothelin-1 concentration in patients with pulmonary arterial hypertension. | Circulation journal : official journal of the Japanese Circulation Society 20070301 |
| Observational trials in pulmonary arterial hypertension: low scientific evidence but high clinical value. | The European respiratory journal 20070301 |
| Endothelin-1 receptors play a minor role in the protection against acute Trypanosoma cruzi infection in mice. | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20070301 |
| Endothelin receptor antagonists in the treatment of pulmonary arterial hypertension. | Clinics in chest medicine 20070301 |
| Combination therapy and new types of agents for pulmonary arterial hypertension. | Clinics in chest medicine 20070301 |
| Chronic thromboembolic pulmonary hypertension. | Clinics in chest medicine 20070301 |
| [Pulmonary hypertension treatment: future prospects]. | Archivos de bronconeumologia 20070301 |
| [Digital necrosis in scleroderma]. | La Revue du praticien 20070227 |
| Assessment of digital vascular structure and function in response to bosentan in patients with systemic sclerosis-related Raynaud's phenomenon. | Rheumatology (Oxford, England) 20070201 |
| Dietary protein induces endothelin-mediated kidney injury through enhanced intrinsic acid production. | Kidney international 20070201 |
| Bosentan and sildenafil: should the combination therapy be a valid alternative in childhood to prostacyclin infusion? | Pediatric transplantation 20070201 |
| Quality of life in pulmonary arterial hypertension: improvement and maintenance with bosentan. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20070201 |
| Long-term trial of bosentan monotherapy for pulmonary arterial hypertension in Japanese patients. | Current medical research and opinion 20070201 |
| [Role of bosentan in patients with chronic venous thromboembolic pulmonary hypertension]. | Medicina clinica 20070113 |
| Long-term bosentan in chronic thromboembolic pulmonary hypertension. | Respiration; international review of thoracic diseases 20070101 |
| Increased vascular contractility in isolated vessels from cigarette smoking rats is mediated by basal endothelin release. | Vascular pharmacology 20070101 |
| Effects of bosentan, an endothelin receptor antagonist, on bile salt export pump and multidrug resistance-associated protein 2. | Biopharmaceutics & drug disposition 20070101 |
| Assessment and treatment of pulmonary arterial hypertension: an Australian perspective in 2006. | Internal medicine journal 20070101 |
| Bosentan as a rescue therapy in scleroderma refractory digital ulcers. | Archives of dermatology 20070101 |
| Sitaxsentan treatment for patients with pulmonary arterial hypertension discontinuing bosentan. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20070101 |
| Bosentan use in systemic lupus erythematosus patients with pulmonary arterial hypertension. | Lupus 20070101 |
| [Chronic thromboembolic pulmonary hypertension]. | Cirugia y cirujanos 20070101 |
| Bosentan for increased pulmonary vascular resistance in a patient with single ventricle physiology and a bidirectional Glenn shunt. | Pediatric cardiology 20070101 |
| [Treatment of digital ulcers in systemtic sclerosis with endothelin-1 receptor antagonist (bosentan)]. | Reumatismo 20070101 |
| Endothelin-1 blockade prevents COX2 induction and TXA2 production in the fructose hypertensive rat. | Canadian journal of physiology and pharmacology 20070101 |
| [Digital ulcers in a cohort of 333 scleroderma patients]. | Reumatismo 20070101 |
| High-dose bosentan in the prevention and treatment of subarachnoid hemorrhage-induced cerebral vasospasm: an open-label feasibility study. | Neurocritical care 20070101 |
| Consecutive use of sildenafil and bosentan for the treatment of pulmonary arterial hypertension associated with collagen vascular disease: sildenafil as reliever and bosentan as controller. | Lupus 20070101 |
| [Observational study of the efficacy and tolerability of bosentan for the treatment of pulmonary hypertension in a tertiary referral hospital]. | Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20070101 |
| Sustained success of therapy with inhaled iloprost for severe pulmonary arterial hypertension associated with systemic sclerosis and pulmonary fibrosis. | Clinical and experimental rheumatology 20070101 |
| [Two-years therapy with bosentan of pulmonary arterial hypertension related to connective tissue diseases]. | Reumatismo 20070101 |
| Should right ventricle dilatation during exercise have clinical implications in patients with chronic thromboembolic pulmonary hypertension? Case report. | Cardiovascular ultrasound 20070101 |
| [Pulmonary hypertension and right ventricular failure. Part XI. Endothelin receptor blockers in the treatment of primary pulmonary arterial hypertension]. | Kardiologiia 20070101 |
| [Treatment of pulmonary arterial hypertension: endothelin-receptor antagonists]. | Deutsche medizinische Wochenschrift (1946) 20061208 |
| [Pulmonary hypertension in HIV patients]. | Deutsche medizinische Wochenschrift (1946) 20061208 |
| [Pulmonary arterial hypertension following pulmonary thromboembolism]. | Deutsche medizinische Wochenschrift (1946) 20061208 |
| [Drug combination treatment for pulmonary arterial hypertension]. | Deutsche medizinische Wochenschrift (1946) 20061208 |
| Long-term outcome in pulmonary arterial hypertension patients treated with subcutaneous treprostinil. | The European respiratory journal 20061201 |
| Randomized study of adding inhaled iloprost to existing bosentan in pulmonary arterial hypertension. | American journal of respiratory and critical care medicine 20061201 |
| [Chronic pulmonary thromboembolism revealing beta-thalassemia intermedia after splenectomy]. | La Revue de medecine interne 20061201 |
| Bosentan increases myocardial perfusion and function in systemic sclerosis: a magnetic resonance imaging and Tissue-Doppler echography study. | The Journal of rheumatology 20061201 |
| Short-term and long-term FK506 treatment alters the vascular reactivity of renal and mesenteric vascular beds. | Journal of pharmacological sciences 20061201 |
| Efficacy of bosentan in treatment of unresponsive cutaneous ulceration in disabling pansclerotic morphea in children. | The Journal of rheumatology 20061201 |
| [Systemic sclerosis: paths into the future]. | Presse medicale (Paris, France : 1983) 20061201 |
| [Pulmonary arterial hypertension and systemic sclerosis]. | Presse medicale (Paris, France : 1983) 20061201 |
| [Long-term outcomes of treatment with bosentan in pulmonary hypertension]. | Archivos de bronconeumologia 20061201 |
| [Porto-pulmonary hypertension]. | Revue des maladies respiratoires 20061201 |
| Pharmacologic treatment for pulmonary arterial hypertension. | Current opinion in cardiology 20061101 |
| Effects of blockade of the renin-angiotensin and endothelin systems on experimental bronchiolitis obliterans. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20061101 |
| Conversion to bosentan from prostacyclin infusion therapy in pulmonary arterial hypertension: a pilot study. | Chest 20061101 |
| Treatment of pulmonary arterial hypertension. | Jornal de pediatria 20061101 |
| Bosentan improved syncope in a hemodialysis patient with pulmonary hypertension and mild aortic stenosis. | International heart journal 20061101 |
| Safety and efficacy of inhaled treprostinil as add-on therapy to bosentan in pulmonary arterial hypertension. | Journal of the American College of Cardiology 20061003 |
| Myocardial dysfunction and neurohumoral activation without remodeling in left ventricle of monocrotaline-induced pulmonary hypertensive rats. | American journal of physiology. Heart and circulatory physiology 20061001 |
| Bosentan treatment for pulmonary arterial hypertension related to connective tissue disease: a subgroup analysis of the pivotal clinical trials and their open-label extensions. | Annals of the rheumatic diseases 20061001 |
| Efficiency and safety of bosentan in child C cirrhosis with portopulmonary hypertension and renal insufficiency. | European journal of gastroenterology & hepatology 20061001 |
| Successful treatment of patients with severe secondary Raynaud's phenomenon with the endothelin receptor antagonist bosentan. | Rheumatology (Oxford, England) 20061001 |
| Weaning of epoprostenol in a small infant receiving concomitant bosentan for severe pulmonary arterial hypertension secondary to bronchopulmonary dysplasia. | Minerva pediatrica 20061001 |
| Combining inhaled iloprost with bosentan in patients with idiopathic pulmonary arterial hypertension. | The European respiratory journal 20061001 |
| The current treatment of pulmonary arterial hypertension: time to redefine success. | Chest 20061001 |
| Combination therapy with sildenafil and bosentan reverts severe pulmonary hypertension and allows heart transplantation: case report. | Transplantation proceedings 20061001 |
| Role of endothelin-1 in exposure to high altitude: Acute Mountain Sickness and Endothelin-1 (ACME-1) study. | Circulation 20060926 |
| Endothelin-1 and the pulmonary vascular response to altitude: a new therapeutic target? | Circulation 20060926 |
| Early-onset endothelin receptor blockade in hypertensive heterozygous Ren-2 rats. | Vascular pharmacology 20060901 |
| An evidence-based approach to the management of pulmonary arterial hypertension. | Current opinion in cardiology 20060901 |
| Dual endothelin receptor antagonism in pulmonary arterial hypertension. | European journal of clinical investigation 20060901 |
| Dual ET(A)/ET(B) vs. selective ET(A) endothelin receptor antagonism in patients with pulmonary hypertension. | European journal of clinical investigation 20060901 |
| Survival in patients with pulmonary arterial hypertension treated with first-line bosentan. | European journal of clinical investigation 20060901 |
| Current treatment options in children with pulmonary arterial hypertension and experiences with oral bosentan. | European journal of clinical investigation 20060901 |
| Bosentan for the treatment of pulmonary arterial hypertension associated with congenital heart defects. | European journal of clinical investigation 20060901 |
| First experience with an oral combination therapy using bosentan and sildenafil for pulmonary arterial hypertension. | European journal of clinical investigation 20060901 |
| Bosentan in Eisenmenger syndrome and chronic thromboembolic pulmonary hypertension. | European journal of clinical investigation 20060901 |
| Bosentan for severe pulmonary arterial hypertension related to systemic sclerosis with interstitial lung disease. | European journal of clinical investigation 20060901 |
| Bosentan therapy of pulmonary arterial hypertension in connective tissue diseases. | European journal of clinical investigation 20060901 |
| Endothelin and endothelin receptor antagonism in portopulmonary hypertension. | European journal of clinical investigation 20060901 |
| Successful treatment of portopulmonary hypertension with bosentan: case report. | European journal of clinical investigation 20060901 |
| Bosentan treatment of portopulmonary hypertension related to liver cirrhosis owing to hepatitis C. | European journal of clinical investigation 20060901 |
| Bosentan therapy for pulmonary arterial hypertension associated with hereditary haemorrhagic telangiectasia. | European journal of clinical investigation 20060901 |
| Clinical outcomes of bosentan in pulmonary arterial hypertension do not correlate with levels of TIMPs. | European journal of clinical investigation 20060901 |
| Bosentan improves functional class, pulmonary artery systolic pressure, and DLCO in scleroderma patients with pulmonary hypertension: a possible synergy with iloprost. | The Journal of rheumatology 20060901 |
| Highly active antiretroviral therapy compared with HAART and bosentan in combination in patients with HIV-associated pulmonary hypertension. | Heart (British Cardiac Society) 20060801 |
| Bosentan for the treatment of systemic sclerosis-associated pulmonary arterial hypertension, pulmonary fibrosis and digital ulcers. | Expert opinion on pharmacotherapy 20060801 |
| Blocking ET-1 receptors does not correct subnormal retinal oxygenation response in experimental diabetic retinopathy. | Investigative ophthalmology & visual science 20060801 |
| Long-term results after addition of sildenafil in idiopathic PAH patients on bosentan. | Southern medical journal 20060801 |
| Endothelin-1 receptor blockade prevented the electrophysiological dysfunction in cardiac myocytes of streptozotocin-induced diabetic rats. | Endocrine 20060801 |
| Bosentan therapy in patients with Eisenmenger syndrome: a multicenter, double-blind, randomized, placebo-controlled study. | Circulation 20060704 |
| Elevated endothelin-1 levels impair nitric oxide homeostasis through a PKC-dependent pathway. | Circulation 20060704 |
| Bosentan, an endothelin receptor antagonist, reduces leucocyte adhesion and inflammation in a murine model of inflammatory bowel disease. | International journal of colorectal disease 20060701 |
| Systemic sclerosis associated pulmonary hypertension: improved survival in the current era. | Heart (British Cardiac Society) 20060701 |
| Treatment of severe Raynaud's phenomenon with bosentan in a patient with systemic sclerosis. | Rheumatology (Oxford, England) 20060701 |
| Orofacial cold hyperalgesia due to infraorbital nerve constriction injury in rats: reversal by endothelin receptor antagonists but not non-steroidal anti-inflammatory drugs. | Pain 20060701 |
| The efficacy of bosentan in inoperable chronic thromboembolic pulmonary hypertension: a 1-year follow-up study. | The European respiratory journal 20060701 |
| An evidence-based approach to the management of pulmonary arterial hypertension. | Current opinion in cardiology 20060701 |
| [Evidence-based therapy of Raynaud's syndrome]. | Zeitschrift fur Rheumatologie 20060701 |
| Blockade of endothelin ET(A)/ET(B) receptors favors a role for endothelin during acute Trypanosoma cruzi infection in rats. | Microbes and infection 20060701 |
| [Pulmonary arterial hypertension. Therapy with the endothelin-1 receptor antagonist bosentan]. | Medizinische Monatsschrift fur Pharmazeuten 20060701 |
| [Endothelin]. | Nihon rinsho. Japanese journal of clinical medicine 20060701 |
| [Transition from prostacyclin to bosentan in five patients with severe pulmonary hypertension: the switch is possible]. | Revista espanola de cardiologia 20060701 |
| Cardioprotective effects of bosentan, a mixed endothelin type A and B receptor antagonist, during myocardial ischaemia and reperfusion in rats. | Basic & clinical pharmacology & toxicology 20060601 |
| Does rapid dose titration affect the hepatic safety profile of Bosentan? | Vascular pharmacology 20060601 |
| Bosentan for the treatment of pulmonary arterial hypertension associated with congenital cardiac disease. | Cardiology in the young 20060601 |
| Current understanding of the role of bosentan in inoperable chronic thromboembolic pulmonary hypertension. | Expert opinion on pharmacotherapy 20060601 |
| Bosentan, sildenafil, and their combination in the monocrotaline model of pulmonary hypertension in rats. | Experimental biology and medicine (Maywood, N.J.) 20060601 |
| Targeting the endothelin axis in human melanoma: combination of endothelin receptor antagonism and alkylating agents. | Experimental biology and medicine (Maywood, N.J.) 20060601 |
| Endothelin ET(B) receptor antagonist reduces mechanical allodynia in rats with trigeminal neuropathic pain. | Experimental biology and medicine (Maywood, N.J.) 20060601 |
| Drug-related hepatotoxicity. | The New England journal of medicine 20060518 |
| Treatment of pulmonary arterial hypertension with the selective endothelin-A receptor antagonist sitaxsentan. | Journal of the American College of Cardiology 20060516 |
| [Bosentan: a new pillar in the treatment of pulmonary hypertension?]. | Deutsche medizinische Wochenschrift (1946) 20060505 |
| Long-term bosentan treatment in children with pulmonary arterial hypertension. | Journal of the American College of Cardiology 20060502 |
| Response to bosentan in children with pulmonary hypertension. | Heart (British Cardiac Society) 20060501 |
| Chronic exercise does not prevent hypoxia-induced increased aortic sensitivity to endothelin in rats. | Vascular pharmacology 20060501 |
| Contribution of endothelin-1 to the enhanced carotid body chemosensory responses induced by chronic intermittent hypoxia. | Brain research 20060501 |
| Bosentan may induce arthritis flare in patients with scleroderma concomitantly treated with methotrexate. | Annals of the rheumatic diseases 20060501 |
| Successful treatment of systemic sclerosis-related digital ulcers and sarcoidosis with endothelin receptor antagonist (bosentan) therapy. | The British journal of dermatology 20060501 |
| Prediction of hepatic clearance using cryopreserved human hepatocytes: a comparison of serum and serum-free incubations. | The Journal of pharmacy and pharmacology 20060501 |
| Sildenafil, a PDE5 inhibitor, in the treatment of pulmonary hypertension. | Expert review of cardiovascular therapy 20060501 |
| Endothelin B receptor antagonist increases preproendothelin-1 transcription in bovine aortic endothelial cells and in vivo. | Journal of cardiovascular pharmacology 20060501 |
| [The effect of an endothelin receptor antagonist in Eisenmenger syndrome: a single-center experience of 11 patients]. | Archives des maladies du coeur et des vaisseaux 20060501 |
| [Pulmonary fibrosis--a therapeutic dilemma?]. | Medizinische Klinik (Munich, Germany : 1983) 20060415 |
| Effect of endothelin receptor antagonist on parathyroid gland growth, PTH values and cell proliferation in azotemic rats. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20060401 |
| Preliminary experience with bosentan as initial therapy in childhood idiopathic pulmonary arterial hypertension. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20060401 |
| Efficacy of bosentan in a small cohort of adult patients with pulmonary arterial hypertension related to congenital heart disease. | Chest 20060401 |
| [Bosentan for treatment of active digital ulcers in patients with systemic sclerosis]. | Presse medicale (Paris, France : 1983) 20060401 |
| [Intestinal blood flow alterations in postoperative intraabdominal adhesion formation and the role of Endothelin-1 blockade]. | Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES 20060401 |
| [Diagnosis and treatment of pulmonary hypertension]. | Deutsche medizinische Wochenschrift (1946) 20060324 |
| Bosentan preserves endothelial function in mice overexpressing APP. | Neurobiology of aging 20060301 |
| Long-term outcome with first-line bosentan therapy in idiopathic pulmonary arterial hypertension. | European heart journal 20060301 |
| Therapeutic management of idiopathic pulmonary fibrosis: an evidence-based approach. | Clinics in chest medicine 20060301 |
| Pharmacokinetic interaction between bosentan and the oral contraceptives norethisterone and ethinyl estradiol. | International journal of clinical pharmacology and therapeutics 20060301 |
| Inhibition of endothelin-1-mediated up-regulation of iNOS by bosentan ameliorates endotoxin-induced liver injury in cirrhosis. | Shock (Augusta, Ga.) 20060301 |
| Influence of renal denervation on renal effects of acute nitric oxide and ETA/ETB receptor inhibition in conscious normotensive rats. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20060301 |
| Endothelin-induced increased nitric oxide mediates augmented distal nephron acidification as a result of dietary protein. | Journal of the American Society of Nephrology : JASN 20060201 |
| Successful switch from long-term intravenous iloprost to non-invasive combination therapy in idiopathic pulmonary arterial hypertension. | Wiener klinische Wochenschrift 20060201 |
| Improvement in cardiac function of diabetic rats by bosentan is not associated with changes in the activation of PKC isoforms. | Molecular and cellular biochemistry 20060101 |
| Role of endothelins and nitric oxide in the pulmonary circulation of perinatal lambs during hyperoxia and hypoxia. | Pediatric research 20060101 |
| Bosentan in pulmonary arterial hypertension secondary to scleroderma. | The Journal of rheumatology 20060101 |
| Selective serotonin reuptake inhibitor use and outcomes in pulmonary arterial hypertension. | Pulmonary pharmacology & therapeutics 20060101 |
| Initial experience with bosentan therapy in patients considered ineligible for heart transplantation because of severe pulmonary hypertension. | Clinical transplantation 20060101 |
| Persistent painful indurated erythema secondary to bosentan. | Acta dermato-venereologica 20060101 |
| Role of endothelin-1 on the enhanced carotid body activity induced by chronic intermittent hypoxia. | Advances in experimental medicine and biology 20060101 |
| Clinical features and endothelin receptor antagonist in primary Sjögren's syndrome with pulmonary arterial hypertension. | Scandinavian journal of rheumatology 20060101 |
| Drug eruption due to bosentan in a patient with systemic sclerosis. | Modern rheumatology 20060101 |
| Bosentan: a review of its use in pulmonary arterial hypertension and systemic sclerosis. | American journal of cardiovascular drugs : drugs, devices, and other interventions 20060101 |
| Pulmonary hypertension in older children: new approaches and therapies. | Paediatric respiratory reviews 20060101 |
| Bosentan inhibits tumor vascularization and bone metastasis in an immunocompetent skin-fold chamber model of breast carcinoma cell metastasis. | Clinical & experimental metastasis 20060101 |
| Public funding of bosentan for the treatment of pulmonary artery hypertension in Australia: cost effectiveness and risk sharing. | PharmacoEconomics 20060101 |
| Endothelin. | Handbook of experimental pharmacology 20060101 |
| Effects of endothelin receptor blockade on hypervasoreactivity in streptozotocin-diabetic rats: vessel-specific involvement of thromboxane A2. | Canadian journal of physiology and pharmacology 20060101 |
| An open-label, multicentre pilot study of bosentan in pulmonary arterial hypertension related to congenital heart disease. | Canadian respiratory journal 20060101 |
| PHARMAC responds on treatments for pulmonary arterial hypertension. | The New Zealand medical journal 20051216 |
| Endothelin-mediated increases in lung VEGF content promote vascular leak in young rats exposed to viral infection and hypoxia. | American journal of physiology. Lung cellular and molecular physiology 20051201 |
| Survival in patients with class III idiopathic pulmonary arterial hypertension treated with first line oral bosentan compared with an historical cohort of patients started on intravenous epoprostenol. | Thorax 20051201 |
| New therapeutic agents for pulmonary vascular disease. | Paediatric respiratory reviews 20051201 |
| Improving survival in idiopathic pulmonary arterial hypertension: revisiting the 'kingdom of the near-dead'. | Thorax 20051201 |
| Possible reduction in indinavir serum concentrations by bosentan. | Therapeutic drug monitoring 20051201 |
| Effect of chronic endothelin blockade on PKC isoform distribution in mesenteric arteries from diabetic rats. | Molecular and cellular biochemistry 20051201 |
| Endothelins: pathophysiology and treatment implications in chronic heart failure. | Current heart failure reports 20051201 |
| [Pharmacological characteristics and clinical efficacy of bosentan]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20051201 |
| PHARMAC not funding some treatments for rare, life-threatening diseases: bosentan as an example. | The New Zealand medical journal 20051125 |
| Images in cardiovascular medicine. Medical treatment of varicose veins. | Circulation 20051108 |
| Effect of the oral endothelin antagonist bosentan on the clinical, exercise, and haemodynamic status of patients with pulmonary arterial hypertension related to congenital heart disease. | Heart (British Cardiac Society) 20051101 |
| Goal-oriented treatment and combination therapy for pulmonary arterial hypertension. | The European respiratory journal 20051101 |
| Early endothelin-A receptor blockade decreases blood pressure and ameliorates end-organ damage in homozygous Ren-2 rats. | Hypertension (Dallas, Tex. : 1979) 20051001 |
| Adult patients with congenital heart disease and pulmonary arterial hypertension: first open prospective multicenter study of bosentan therapy. | American heart journal 20051001 |
| Long-term outcome of bosentan treatment in idiopathic pulmonary arterial hypertension and pulmonary arterial hypertension associated with the scleroderma spectrum of diseases. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20051001 |
| [A role for combination therapy in pulmonary arterial hypertension]. | Pneumologie (Stuttgart, Germany) 20051001 |
| Bosentan therapy for inoperable chronic thromboembolic pulmonary hypertension. | Chest 20051001 |
| Bosentan therapy for inoperable chronic thromboembolic pulmonary hypertension. | Chest 20051001 |
| Treatment of pulmonary hypertension secondary to alveolar microlithiasis with Bosentan: a case report. | Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG 20051001 |
| [The therapeutic effects of bosentan and valsartan on renal interstitial fibrosis of chronic aristolochic acid nephropathy]. | Zhonghua yi xue za zhi 20050928 |
| Alterations in vascular matrix metalloproteinase due to ageing and chronic hypertension: effects of endothelin receptor blockade. | Journal of hypertension 20050901 |
| Initial experience with bosentan (Tracleer) as treatment for pulmonary arterial hypertension (PAH) due to congenital heart disease in infants and young children. | Zeitschrift fur Kardiologie 20050901 |
| [Pulmonary arterial hypertension]. | Revue des maladies respiratoires 20050901 |
| Effects of long-term bosentan in children with pulmonary arterial hypertension. | Journal of the American College of Cardiology 20050816 |
| Improving the outcome of childhood pulmonary arterial hypertension: the effect of bosentan in the setting of a dedicated pulmonary hypertension clinic. | Journal of the American College of Cardiology 20050816 |
| Decreased exhaled nitric oxide in pulmonary arterial hypertension: response to bosentan therapy. | American journal of respiratory and critical care medicine 20050801 |
| A urinary test for pulmonary arterial hypertension? | American journal of respiratory and critical care medicine 20050801 |
| Bosentan in inoperable chronic thromboembolic pulmonary hypertension. | Thorax 20050801 |
| Bosentan improves exercise tolerance and Tei index in patients with pulmonary hypertension and prostanoid therapy. | Chest 20050801 |
| Bosentan induces clinical, exercise and hemodynamic improvement in a pre-transplant patient with plastic bronchitis after Fontan operation. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20050801 |
| Endothelin antagonism in pulmonary arterial hypertension. | Seminars in respiratory and critical care medicine 20050801 |
| Changing the prognosis of pulmonary arterial hypertension: impact of medical therapy. | Seminars in respiratory and critical care medicine 20050801 |
| [Endothelin]. | Nihon rinsho. Japanese journal of clinical medicine 20050801 |
| Combination therapy for portopulmonary hypertension with intravenous iloprost and oral bosentan. | Wiener medizinische Wochenschrift (1946) 20050801 |
| The role of endothelin in FK506-induced vascular reactivity changes in rat perfused kidney. | European journal of pharmacology 20050704 |
| Endothelin-induced increased aldosterone activity mediates augmented distal nephron acidification as a result of dietary protein. | Journal of the American Society of Nephrology : JASN 20050701 |
| Bosentan decreases the plasma concentration of sildenafil when coprescribed in pulmonary hypertension. | British journal of clinical pharmacology 20050701 |
| Combination therapy with bosentan and phosphodiesterase-5 inhibitor in pulmonary arterial hypertension. | The European respiratory journal 20050701 |
| [Portopulmonary hypertension]. | Zeitschrift fur Gastroenterologie 20050701 |
| Treatment of pulmonary arterial hypertension with bosentan: from pathophysiology to clinical evidence. | Expert opinion on pharmacotherapy 20050701 |
| Bosentan, the mixed ETA-ETB endothelin receptor antagonist, attenuated oxidative stress after experimental myocardial ischemia and reperfusion. | Molecular and cellular biochemistry 20050701 |
| [Pulmonary hypertension in hereditary haemorrhagic teleangiectasia (Rendu-Osler-Weber disease). Progression over 10 years]. | Deutsche medizinische Wochenschrift (1946) 20050610 |
| Sildenafil versus Endothelin Receptor Antagonist for Pulmonary Hypertension (SERAPH) study. | American journal of respiratory and critical care medicine 20050601 |
| Pulmonary arterial hypertension: the race for the most effective treatment. | American journal of respiratory and critical care medicine 20050601 |
| Severe left ventricular dysfunction secondary to primary pulmonary hypertension: bridging therapy with bosentan before lung transplantation. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20050601 |
| Effect of bosentan treatment on surrogate markers in pulmonary arterial hypertension. | Current medical research and opinion 20050601 |
| Pulmonary hypertension: its diagnosis and management, a multidisciplinary approach. | The Netherlands journal of medicine 20050601 |
| [PAH in congenital heart defects--therapeutic experiences with children and adults]. | Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege 20050601 |
| Resolution of severe digital ulceration during a course of Bosentan therapy. | Annals of internal medicine 20050503 |
| Hemodynamic observations in two pulmonary hypertensive patients changing treatment from inhaled iloprost to the oral endothelin-antagonist bosentan. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20050501 |
| The endothelin-1 receptor antagonist bosentan protects against ischaemia/reperfusion-induced endothelial dysfunction in humans. | Clinical science (London, England : 1979) 20050401 |
| New hope for systemic sclerosis patients with digital ulcers. | Current rheumatology reports 20050401 |
| Role of the endothelin-1 system in the luteolytic process of pseudopregnant rabbits. | Endocrinology 20050301 |
| Cardioprotective effect of an endothelin receptor antagonist during ischaemia/reperfusion in the severely atherosclerotic mouse heart. | British journal of pharmacology 20050301 |
| Bosentan therapy for portopulmonary hypertension. | The European respiratory journal 20050301 |
| When cure is care: diagnosis and management of pulmonary arterial hypertension. | Journal of the American Academy of Nurse Practitioners 20050301 |
| The effect of bosentan on matrix metalloproteinase-9 levels in patients with systemic sclerosis-induced pulmonary hypertension. | Current medical research and opinion 20050301 |
| Eisenmenger's syndrome in a 27 week pregnancy--management with bosentan and sildenafil. | Irish medical journal 20050301 |
| Endothelin A and B receptor antagonist bosentan reduces postischemic myocardial injury in the rat: critical timing of administration. | Canadian journal of physiology and pharmacology 20050301 |
| Eisenmenger syndrome in the adult--experience with new drugs for the treatment of pulmonary hypertension. | Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 20050301 |
| [Cytokine antagonists and endothelin antagonists for therapy of heart failure]. | Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20050210 |
| Xenobiotics inhibit hepatic uptake and biliary excretion of taurocholate in rat hepatocytes. | Toxicological sciences : an official journal of the Society of Toxicology 20050201 |
| Effect of bosentan (ETA/ETB receptor antagonist) on metabolic changes during stress and diabetes. | Pharmacological research 20050201 |
| The right ventricle in pulmonary hypertension. | Coronary artery disease 20050201 |
| Initial experience with Bosentan therapy in patients with the Eisenmenger syndrome: Tetralogy of Fallot? | The American journal of cardiology 20050201 |
| Effects of the endothelin receptor antagonist bosentan on hemodynamics, symptoms and functional capacity in Japanese patients with severe pulmonary hypertension. | Circulation journal : official journal of the Japanese Circulation Society 20050201 |
| Improving survival in pulmonary arterial hypertension. | The European respiratory journal 20050201 |
| Survival with first-line bosentan in patients with primary pulmonary hypertension. | The European respiratory journal 20050201 |
| Clinical effects of endothelin receptor antagonism with bosentan in patients with severe chronic heart failure: results of a pilot study. | Journal of cardiac failure 20050201 |
| The impact of finally publishing a negative study: new conclusions about endothelin antagonists. | Journal of cardiac failure 20050201 |
| Combination of sildenafil and bosentan for nitric oxide withdrawal. | European journal of anaesthesiology 20050201 |
| [Bosentan]. | Revue de l'infirmiere 20050201 |
| [New choice of therapy of pulmonary hypertension: endothelin receptor antagonist]. | Zhonghua yi xue za zhi 20050126 |
| Endothelin receptor antagonists for pulmonary arterial hypertension. | The Cochrane database of systematic reviews 20050125 |
| A high-salt diet stimulates thick ascending limb eNOS expression by raising medullary osmolality and increasing release of endothelin-1. | American journal of physiology. Renal physiology 20050101 |
| Hepatocyte growth factor induces an endothelin-mediated decline in glomerular filtration rate. | American journal of physiology. Renal physiology 20050101 |
| Comparative investigation of the pharmacokinetics of bosentan in Caucasian and Japanese healthy subjects. | Journal of clinical pharmacology 20050101 |
| Use of a mixed endothelin receptor antagonist in portopulmonary hypertension: a safe and effective therapy? | Gastroenterology 20050101 |
| Safety and tolerability of bosentan in adults with Eisenmenger physiology. | International journal of cardiology 20050101 |
| Comparison of clearance predictions using primary cultures and suspensions of human hepatocytes. | Xenobiotica; the fate of foreign compounds in biological systems 20050101 |
| Role of endothelin in fibrosis and anti-fibrotic potential of bosentan. | Annals of medicine 20050101 |
| Successful therapy of bosentan-refractory pulmonary arterial hypertension (PAH) with inhalative iloprost. | Clinical and experimental rheumatology 20050101 |
| Pulmonary hypertension and right heart failure in chronic obstructive pulmonary disease. | Proceedings of the American Thoracic Society 20050101 |
| [Course of pulmonary artery hypertension disease]. | Krankenpflege Journal 20050101 |
| Risk management strategies in the postmarketing period : safety experience with the US and European bosentan surveillance programmes. | Drug safety 20050101 |
| Combination drug therapy in the management of pulmonary arterial hypertension. | Progress in cardiovascular nursing 20050101 |
| Functional and metabolic recovery of the right ventricle during Bosentan therapy in idiopathic pulmonary arterial hypertension. | Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20050101 |
| Secondary pulmonary arterial hypertension: treated with endothelin receptor blockade. | Texas Heart Institute journal 20050101 |
| [Endothelin receptor antagonism in routine clinical care]. | Krankenpflege Journal 20050101 |
| Increased endothelin activity mediates augmented distal nephron acidification induced by dietary protein. | Transactions of the American Clinical and Climatological Association 20050101 |
| [Endothelin receptor antagonist bosentan. Breakthrough in the treatment of pulmonary hypertension]. | MMW Fortschritte der Medizin 20041209 |
| Endothelin receptor antagonist bosentan improves survival in a murine caecal ligation and puncture model of septic shock. | European journal of pharmacology 20041203 |
| Bosentan for the treatment of human immunodeficiency virus-associated pulmonary arterial hypertension. | American journal of respiratory and critical care medicine 20041201 |
| Zebrafish IRX1b in the embryonic cardiac ventricle. | Developmental dynamics : an official publication of the American Association of Anatomists 20041201 |
| Combination therapy with bosentan and sildenafil in idiopathic pulmonary arterial hypertension. | The European respiratory journal 20041201 |
| Digital ulcers in systemic sclerosis: prevention by treatment with bosentan, an oral endothelin receptor antagonist. | Arthritis and rheumatism 20041201 |
| [Treatment of pulmonary arterial hypertension (PAH) with oral endothelin-receptor antagonist bosentan in systemic sclerosis: BREATHE-1 trial and clinical experience]. | Zeitschrift fur Rheumatologie 20041201 |
| Bosentan inhibits transient receptor potential channel expression in pulmonary vascular myocytes. | American journal of respiratory and critical care medicine 20041115 |
| Extracellular signal-regulated kinase (ERK) in glucose-induced and endothelin-mediated fibronectin synthesis. | Laboratory investigation; a journal of technical methods and pathology 20041101 |
| Successful treatment of severe Raynaud's phenomenon with bosentan in four patients with systemic sclerosis. | Rheumatology (Oxford, England) 20041101 |
| Endothelin-receptor antagonist treatment of portopulmonary hypertension. | Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20041101 |
| Pharmacological characterization of YM598, a selective endothelin-A receptor antagonist. | Journal of cardiovascular pharmacology 20041101 |
| [Treatments for pulmonary arterial hypertension]. | La Revue de medecine interne 20041001 |
| Successful switch from inhalative iloprost to oral bosentan in portopulmonary hypertension associated with liver cirrhosis. | Wiener klinische Wochenschrift 20040930 |
| A new era in the management of pulmonary arterial hypertension related to scleroderma: endothelin receptor antagonism. | Annals of the rheumatic diseases 20040901 |
| Combination of bosentan with epoprostenol in pulmonary arterial hypertension: BREATHE-2. | The European respiratory journal 20040901 |
| Transition from epoprostenol and treprostinil to the oral endothelin receptor antagonist bosentan in patients with pulmonary hypertension. | Chest 20040901 |
| [Pathophysiological significance of endothelin in pulmonary hypertension]. | Nihon rinsho. Japanese journal of clinical medicine 20040901 |
| [Septic shock and endothelin]. | Nihon rinsho. Japanese journal of clinical medicine 20040901 |
| [Prospects for endothelin-related drugs]. | Nihon rinsho. Japanese journal of clinical medicine 20040901 |
| Severe necrotising leucocytoclastic vasculitis in a patient taking bosentan. | BMJ (Clinical research ed.) 20040821 |
| [Treatment of pulmonary arterial hypertension in children]. | Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20040801 |
| Endothelin and pulmonary arterial hypertension. | Seminars in arthritis and rheumatism 20040801 |
| Initial experience with bosentan therapy in patients with the Eisenmenger syndrome. | The American journal of cardiology 20040715 |
| Blood flow alterations in TNBS-induced colitis: role of endothelin receptors. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20040701 |
| [Bosentán, hope or reality for the treatment of pulmonary arterial hypertension]. | Medicina clinica 20040626 |
| Endothelin-3 induced mesenteric vasoconstriction and PMN infiltration in the rat small intestine: role of endothelin receptors. | Regulatory peptides 20040615 |
| Successful treatment of severe portopulmonary hypertension after liver transplantation by bosentan. | Transplantation 20040615 |
| Use of oral endothelin-receptor antagonist bosentan in the treatment of portopulmonary hypertension. | Transplantation 20040615 |
| Combined inhibition of angiotensin II and endothelin suppresses the brain natriuretic peptide response to developing heart failure. | Clinical science (London, England : 1979) 20040601 |
| Analysis of ET-A and ET-B receptors using an isolated perfused rat lung preparation. | Acta physiologica Scandinavica 20040601 |
| Influence of nonselective ET(A)/ET(B) receptor blockade on renal function in conscious rats: effects of renal denervation. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20040601 |
| New answers raise new questions in pulmonary arterial hypertension. | The European respiratory journal 20040601 |
| End points in pulmonary arterial hypertension: the way forward. | The European respiratory journal 20040601 |
| Bosentan therapy for pulmonary arterial hypertension. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20040601 |
| Nitric oxide mediates protective effect of endothelin receptor antagonism during myocardial ischemia and reperfusion. | American journal of physiology. Heart and circulatory physiology 20040501 |
| Role of endogenous endothelin-1 in transplant obliterative airway disease in the rat. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20040501 |
| Treatment of secondary pulmonary hypertension with bosentan and its pharmacokinetic monitoring in ESRD. | American journal of kidney diseases : the official journal of the National Kidney Foundation 20040501 |
| Weaning and discontinuation of epoprostenol in children with idiopathic pulmonary arterial hypertension receiving concomitant bosentan. | The American journal of cardiology 20040401 |
| Physiological involvement of placental endothelin-1 and prostaglandin F2alpha in uteroplacental circulatory disturbance in pregnant rats exposed to heat stress. | Canadian journal of physiology and pharmacology 20040401 |
| Inhibition of organic anion transporting polypeptide-mediated hepatic uptake is the major determinant in the pharmacokinetic interaction between bosentan and cyclosporin A in the rat. | The Journal of pharmacology and experimental therapeutics 20040301 |
| Current medical treatment of pulmonary arterial hypertension. | The Mount Sinai journal of medicine, New York 20040301 |
| [Treatment of pulmonary arterial hypertension associated to systemic sclerosis]. | La Revue de medecine interne 20040301 |
| Bosentan. | Expert review of cardiovascular therapy 20040301 |
| [Involvement of endothelin in the pathogenesis of hypertension and hypertensive target-organ damage]. | Nihon rinsho. Japanese journal of clinical medicine 20040301 |
| Selective or nonselective endothelin receptor blockade in pulmonary arterial hypertension. | American journal of respiratory and critical care medicine 20040215 |
| The role of endothelin in mediating ischemia/hypoxia-induced atrial natriuretic peptide release. | Journal of cardiovascular pharmacology 20040201 |
| New combined treatments avoided transplantation in a child with severe pulmonary hypertension. | Heart (British Cardiac Society) 20040201 |
| The endothelin system in pulmonary arterial hypertension. | Cardiovascular research 20040201 |
| Endothelins contribute towards nociception induced by antigen in ovalbumin-sensitised mice. | British journal of pharmacology 20040201 |
| Endothelins regulate astrocyte gap junctions in rat hippocampal slices. | The European journal of neuroscience 20040201 |
| Coxsackievirus B3 infection compromises endothelial-dependent vasodilation of coronary resistance arteries. | Journal of cardiovascular pharmacology 20040101 |
| Relative roles of endothelin-1 and angiotensin II in experimental post-ischaemic acute renal failure. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20040101 |
| Oncofetal fibronectin in diabetic retinopathy. | Investigative ophthalmology & visual science 20040101 |
| [Therapeutic implications of endothelin antagonists for cardiovascular diseases]. | Harefuah 20040101 |
| Bosentan: a novel agent for the treatment of pulmonary arterial hypertension. | International journal of clinical practice 20040101 |
| Blockade of endothelin receptors attenuates end-organ damage in homozygous hypertensive ren-2 transgenic rats. | Kidney & blood pressure research 20040101 |
| [Updated treatment of primary pulmonary hypertension -- the role of endothelin receptor antagonists]. | Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20040101 |
| New hope for patients with pulmonary hypertension: endothelin receptor antagonists: update for the clinical nurse specialist. | Clinical nurse specialist CNS 20040101 |
| Clinical pharmacology of bosentan, a dual endothelin receptor antagonist. | Clinical pharmacokinetics 20040101 |
| Chronic endothelin receptor blockade reduces end-organ damage independently of blood pressure effects in salt-loaded heterozygous Ren-2 transgenic rats. | Physiological research 20040101 |
| Angiotensin II signaling pathways mediate expression of cardiac T-type calcium channels. | Circulation research 20031212 |
| Bosentan and overcirculation-induced experimental pulmonary arterial hypertension. | Circulation 20031209 |
| Nephroprotective effect of bosentan in diabetic rats. | Journal of cardiovascular pharmacology 20031201 |
| Drug therapy for pulmonary arterial hypertension: what's on the menu today? | Chest 20031201 |
| Treatment of pulmonary arterial hypertension: a preliminary decision analysis. | Chest 20031201 |
| Reinduction of T-type calcium channels by endothelin-1 in failing hearts in vivo and in adult rat ventricular myocytes in vitro. | Circulation 20031118 |
| Endothelin receptor blockers in cardiovascular disease. | Circulation 20031104 |
| Scleroderma: a treatable disease. | Cleveland Clinic journal of medicine 20031101 |
| Endothelin receptor blockade has an oxygen-saving effect in Dahl salt-sensitive rats with heart failure. | American journal of physiology. Heart and circulatory physiology 20031001 |
| Interactions between vasoconstrictors and vasodilators in regulating hemodynamics of distinct vascular beds. | Hypertension (Dallas, Tex. : 1979) 20031001 |
| Protective skeletal muscle arteriolar vasomotion during critical perfusion conditions of osteomyocutaneous flaps is not mediated by nitric oxide and endothelins. | Langenbeck's archives of surgery 20031001 |
| Effects of endothelin and nitric oxide on organ injury, mesenteric ischemia, and survival in experimental models of septic shock. | Acta pharmacologica Sinica 20031001 |
| Endothelin receptor antagonists in the treatment of prostate cancer. | Seminars in oncology 20031001 |
| Effects of bosentan on neointimal response following coronary angioplasty. | European journal of clinical investigation 20030901 |
| Attenuation of renal vasopressin V2 receptor upregulation by bosentan, an ETA/ETB receptor antagonist. | Metabolism: clinical and experimental 20030901 |
| Expression of the serotonin 1b receptor in experimental pulmonary hypertension. | The European respiratory journal 20030901 |
| Bosentan for pulmonary arterial hypertension. | Drug and therapeutics bulletin 20030901 |
| [Dyspnea. When is it pulmonary hypertension?]. | MMW Fortschritte der Medizin 20030821 |
| Endothelin receptor antagonists in heart failure--a refutation of a bold conjecture? | European journal of heart failure 20030801 |
| Bosentan treatment in patients with primary pulmonary hypertension receiving nonparenteral prostanoids. | The European respiratory journal 20030801 |
| [Blockade of endothelin receptor with bosentan--a new principle of treatment in pulmonary arterial hypertension]. | Ugeskrift for laeger 20030714 |
| Dual role of endothelin-1 via ETA and ETB receptors in regulation of cardiac contractile function in mice. | American journal of physiology. Heart and circulatory physiology 20030701 |
| Chronic endothelin receptor blockade prevents both early hyperfiltration and late overt diabetic nephropathy in the rat. | Journal of cardiovascular pharmacology 20030701 |
| Treatment of pulmonary arterial hypertension: a step forward. | Chest 20030701 |
| Effects of the dual endothelin receptor antagonist bosentan in patients with pulmonary arterial hypertension: a 1-year follow-up study. | Chest 20030701 |
| Endothelin receptor blockade and exacerbation of heart failure. | Circulation 20030610 |
| Endothelin receptor blockade in canine oleic acid-induced lung injury. | Intensive care medicine 20030601 |
| The endothelin system in pulmonary hypertension. | Canadian journal of physiology and pharmacology 20030601 |
| Endothelin-1 directly modulates its own secretion: studies utilising the cell immunoblot technique. | Regulatory peptides 20030515 |
| Endothelin and endothelin receptor antagonists in systemic rheumatic disease. | Arthritis and rheumatism 20030501 |
| Effects of the oral endothelin-receptor antagonist bosentan on echocardiographic and doppler measures in patients with pulmonary arterial hypertension. | Journal of the American College of Cardiology 20030416 |
| Endothelin-I receptor antagonist for the treatment of pulmonary arterial hypertension in systemic sclerosis. | Current rheumatology reports 20030401 |
| Pharmacokinetics, safety, and efficacy of bosentan in pediatric patients with pulmonary arterial hypertension. | Clinical pharmacology and therapeutics 20030401 |
| Therapy for primary pulmonary hypertension. | Canadian respiratory journal 20030401 |
| Pulmonary arterial hypertension--the primary pulmonary hypertension syndromes. | The Israel Medical Association journal : IMAJ 20030401 |
| [Renoprotective effects of nonselective endothelin receptor antagonist bosentan on rats with interstitial fibrosis following unilateral ureteral obstruction]. | Zhonghua yi xue za zhi 20030325 |
| Bosentan for the prevention of overcirculation-induced experimental pulmonary arterial hypertension. | Circulation 20030311 |
| The use of sulfonylamido pyrimidines incorporating an unsaturated side chain as endothelin receptor antagonists. | Bioorganic & medicinal chemistry letters 20030310 |
| Endothelin-receptor antagonists are proapoptotic and antiproliferative in human colon cancer cells. | British journal of cancer 20030310 |
| Advances in the treatment of secondary pulmonary hypertension. | Current opinion in pulmonary medicine 20030301 |
| Chronic endothelin antagonism restores cerebrovascular function in diabetes. | Neurosurgery 20030301 |
| Inhibition of in vivo constriction of fetal ductus arteriosus by endothelin receptor blockade in rats. | Pediatric research 20030301 |
| Will endothelin receptor antagonists have a role in heart failure? | The Medical clinics of North America 20030301 |
| Cardiac fibrosis occurs early and involves endothelin and AT-1 receptors in hypertension due to endogenous angiotensin II. | Journal of the American College of Cardiology 20030219 |
| Altered myocardial thin-filament function in the failing Dahl salt-sensitive rat heart: amelioration by endothelin blockade. | Circulation 20030204 |
| [New expansion of endothelin research: perspectives for clinical application of endothelin-receptor antagonists]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20030201 |
| No influence of the endothelin receptor antagonist bosentan on basal and indomethacin-induced reduction of cerebral blood flow in pigs. | Acta anaesthesiologica Scandinavica 20030201 |
| ETA, mixed ETA/ETB receptor antagonists, and protein kinase C inhibitor prevent acute hypoxic pulmonary vasoconstriction: influence of potassium channels. | Journal of cardiovascular pharmacology 20030101 |
| Successful treatment of systemic sclerosis digital ulcers and pulmonary arterial hypertension with endothelin receptor antagonist bosentan. | Rheumatology (Oxford, England) 20030101 |
| Endothelin-1 contributes to the Frank-Starling response in hypertrophic rat hearts. | Hypertension (Dallas, Tex. : 1979) 20030101 |
| Influence of mild liver impairment on the pharmacokinetics and metabolism of bosentan, a dual endothelin receptor antagonist. | Journal of clinical pharmacology 20030101 |
| Endothelin receptor antagonist bosentan improves microcirculatory blood flow in splanchnic organs in septic shock. | Critical care medicine 20030101 |
| Vascular endothelial growth factor induced functional and morphologic signs of endothelial dysfunction in isolated arteries from normal pregnant women. | American journal of obstetrics and gynecology 20030101 |
| Endogenous endothelins and nitric oxide in hypoxic pulmonary vasoconstriction. | The European respiratory journal 20030101 |
| Investigation of the mutual pharmacokinetic interactions between bosentan, a dual endothelin receptor antagonist, and simvastatin. | Clinical pharmacokinetics 20030101 |
| Understanding primary pulmonary hypertension. | Critical care nursing quarterly 20030101 |
| Bosentan. | Heart disease (Hagerstown, Md.) 20030101 |
| Product ion spectral simplification using time-delayed fragment ion capture with tandem linear ion traps. | Rapid communications in mass spectrometry : RCM 20030101 |
| Pulmonary hypertension: new perspectives. | Congestive heart failure (Greenwich, Conn.) 20030101 |
| Bosentan and warfarin interaction. | The Annals of pharmacotherapy 20030101 |
| Bosentan for the treatment of pulmonary arterial hypertension. | The Annals of pharmacotherapy 20030101 |
| Sickle cell crisis and endothelin antagonists. | Critical care nursing quarterly 20030101 |
| [From basic research to clinical results. The OVERTURE, ENABLE, and RENEWAL studies]. | Archivos de cardiologia de Mexico 20030101 |
| [What is new in the treatment of pulmonary artery hypertension?]. | Archivos de cardiologia de Mexico 20030101 |
| Regulation of endothelin-converting enzyme 1 in nephrotic syndrome in rats. | Nephron. Experimental nephrology 20030101 |
| The role of endogenous endothelin in the regulation of uteroplacental and renal blood flow during pregnancy in conscious rats. | Placenta 20030101 |
| [Endothelin receptor blockers--one more agent for the treatment of pulmonary hypertension]. | Kardiologiia 20030101 |
| Effects of bosentan on cellular processes involved in pulmonary arterial hypertension: do they explain the long-term benefit? | Annals of medicine 20030101 |
| Endothelin-1 and heme oxygenase-1 as modulators of sinusoidal tone in the stress-exposed rat liver. | Hepatology (Baltimore, Md.) 20021201 |
| Effects of endothelin-1 (ET-1) and thrombin antagonism on cardiovascular and respiratory dysfunctions during endotoxic shock in pig. | Prostaglandins, leukotrienes, and essential fatty acids 20021201 |
| Endothelin-induced vascular and bronchial effects in pig airways: role in acute allergic responses. | Journal of applied physiology (Bethesda, Md. : 1985) 20021101 |
| Targeting mediators of vascular injury in scleroderma. | Current opinion in rheumatology 20021101 |
| [Young patient with stress dyspnea of uncertain origin. Evaluate for pulmonary hypertension!]. | MMW Fortschritte der Medizin 20021017 |
| Do results of the ENABLE (Endothelin Antagonist Bosentan for Lowering Cardiac Events in Heart Failure) study spell the end for non-selective endothelin antagonism in heart failure? | International journal of cardiology 20021001 |
| Effects of endothelin-1 on release of adrenomedullin and C-type natriuretic peptide from individual human vascular endothelial cells. | The Journal of endocrinology 20021001 |
| Exaggerated coronary reactivity to endothelin-1 in diabetes: reversal with bosentan. | Canadian journal of physiology and pharmacology 20021001 |
| [Antihypertensive treatment in patients with diabetes mellitus]. | Polskie Archiwum Medycyny Wewnetrznej 20021001 |
| Bosentan, a dual endothelin receptor antagonist, activates the pregnane X nuclear receptor. | European journal of pharmacology 20020823 |
| Contribution of mrp2 in alterations of canalicular bile formation by the endothelin antagonist bosentan. | Journal of hepatology 20020801 |
| Endothelin ET(B) receptor-mediated mechanisms involved in oleic acid-induced acute lung injury in mice. | Clinical science (London, England : 1979) 20020801 |
| Bosentan for pulmonary hypertension. | The New England journal of medicine 20020725 |
| Bosentan for pulmonary hypertension. | The New England journal of medicine 20020725 |
| Aortic smooth muscle cell phenotypic modulation and fibrillar collagen deposition in angiotensin II-dependent hypertension. | Cardiovascular research 20020701 |
| Bosentan: a dual endothelin receptor antagonist. | Expert opinion on investigational drugs 20020701 |
| Influence of severe renal dysfunction on the pharmacokinetics and metabolism of bosentan, a dual endothelin receptor antagonist. | International journal of clinical pharmacology and therapeutics 20020701 |
| Endothelin receptor antagonist combined with a calcium channel blocker attenuates renal injury in spontaneous hypertensive rats with diabetes. | Chinese medical journal 20020701 |
| The role of endothelin in oxygen-induced contraction of the ductus arteriosus in rabbit and rat fetuses. | Heart and vessels 20020701 |
| [Treatment of heart failure: an update]. | Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology 20020701 |
| New drugs 2002, part III. | Nursing 20020701 |
| Single- and multiple-dose pharmacokinetics of bosentan and its interaction with ketoconazole. | British journal of clinical pharmacology 20020601 |
| Hyperglycemia exaggerates ischemia-reperfusion-induced cardiomyocyte injury: reversal with endothelin antagonism. | The Journal of thoracic and cardiovascular surgery 20020601 |
| Ease symptoms of pulmonary hypertension with bosentan. | The Nurse practitioner 20020601 |
| Developments in therapeutics for pulmonary arterial hypertension. | Minerva cardioangiologica 20020601 |
| Recent heart failure trials of neurohormonal modulation (OVERTURE and ENABLE): approaching the asymptote of efficacy? | Journal of cardiac failure 20020601 |
| Endothelin B receptor-mediated regulation of endothelin-1 content and release in cultured porcine aorta endothelial cell. | Journal of cardiovascular pharmacology 20020501 |
| Endothelin antagonism and interleukin-6 inhibition attenuate the proatherogenic effects of C-reactive protein. | Circulation 20020423 |
| [2 studies for heart failure therapy. Endothelin receptor antagonist does not improve prognosis]. | MMW Fortschritte der Medizin 20020404 |
| Combined inhibition of neutral endopeptidase with angiotensin converting enzyme or endothelin converting enzyme in experimental diabetes. | Journal of hypertension 20020401 |
| Bosentan (Tracleer) for pulmonary arterial hypertension. | The Medical letter on drugs and therapeutics 20020401 |
| In vivo and in vitro studies exploring the pharmacokinetic interaction between bosentan, a dual endothelin receptor antagonist, and glyburide. | Clinical pharmacology and therapeutics 20020401 |
| Endothelin blockade potentiates endothelial protective effects of ACE inhibitors in saphenous veins. | The Annals of thoracic surgery 20020401 |
| Bosentan therapy for pulmonary arterial hypertension. | The New England journal of medicine 20020321 |
| Treatment of primary pulmonary hypertension -- the next generation. | The New England journal of medicine 20020321 |
| Bosentan enters market with risk management program. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20020315 |
| Influence of food intake and formulation on the pharmacokinetics and metabolism of bosentan, a dual endothelin receptor antagonist. | Journal of clinical pharmacology 20020301 |
| Chronic endothelin receptor blockade prevents renal vasoconstriction and sodium retention in rats with chronic heart failure. | Cardiovascular research 20020301 |
| [Bosentan in pulmonary hypertension]. | Medizinische Monatsschrift fur Pharmazeuten 20020301 |
| Endothelin receptor antagonism attenuates cardiomyocyte apoptosis after induction of ischemia in rats. | Scandinavian cardiovascular journal : SCJ 20020301 |
| Pulmonary hypertension and HIV. | Project Inform perspective 20020301 |
| Endothelin antagonists and heart failure. | Current hypertension reports 20020201 |
| Medical management of primary pulmonary hypertension. | Expert opinion on pharmacotherapy 20020201 |
| Tracleer. Tablets ease symptoms of rare lung disorder. | Nursing 20020201 |
| [Physical endurance improves markedly. New therapy approach in pulmonary hypertension]. | MMW Fortschritte der Medizin 20020117 |
| [The effects of endothelin blockade on renal expression of angiotensin II type 1 receptor in diabetic hypertensive rats]. | Zhonghua yi xue za zhi 20020110 |
| Hyperhexosemia induced functional and structural changes in the kidneys: role of endothelins. | Nephron 20020101 |
| Endothelin is an important determinant of renal function in a rat model of acute liver and renal failure. | Gut 20020101 |
| Direct left ventricular wall stretch activates GATA4 binding in perfused rat heart: involvement of autocrine/paracrine pathways. | Pflugers Archiv : European journal of physiology 20020101 |
| Tracleer (bosentan). | Journal of clinical hypertension (Greenwich, Conn.) 20020101 |
| Medication approved to treat rare lung disorder. | FDA consumer 20020101 |
| MS3 using the collision cell of a tandem mass spectrometer system. | Rapid communications in mass spectrometry : RCM 20020101 |
| Endothelin in health and disease: endothelin receptor antagonists in the management of pulmonary artery hypertension. | Journal of cardiovascular pharmacology and therapeutics 20020101 |
| Endothelin antagonism with bosentan: current status and future perspectives. | Cardiovascular drug reviews 20020101 |
| Use of in vitro organ cultures of human saphenous vein as a model for intimal proliferation. | Methods in molecular biology (Clifton, N.J.) 20020101 |
| Contributions of endothelin-1 and sodium hydrogen exchanger-1 in the diabetic myocardium. | Diabetes/metabolism research and reviews 20020101 |
| Endothelin-1-mediated alteration of metallothionein and trace metals in the liver and kidneys of chronically diabetic rats. | International journal of experimental diabetes research 20020101 |
| Emerging medical therapies for pulmonary arterial hypertension. | Progress in cardiovascular diseases 20020101 |
| Bosentan. | American journal of cardiovascular drugs : drugs, devices, and other interventions 20020101 |
| Coronary and aortic vasoreactivity protection with endothelin receptor antagonist, bosentan, after ischemia and hypoxia in aged rats. | European journal of pharmacology 20011207 |
| Therapeutic role of bosentan in hypertension: lessons from the model of perinephritic hypertension. | Heart failure reviews 20011201 |
| Hemodynamic effects of bosentan in patients with chronic heart failure. | Heart failure reviews 20011201 |
| Endothelin and heart failure. | Heart failure reviews 20011201 |
| Endothelin resets renal blood flow autoregulatory efficiency during acute blockade of NO in the rat. | American journal of physiology. Renal physiology 20011201 |
| Endothelin antagonist reduces hemodynamic responses to vasopressin in DOCA-salt hypertension. | American journal of physiology. Heart and circulatory physiology 20011201 |
| Role of endogenous endothelin on coronary reflow after cardioplegic arrest. | The Journal of thoracic and cardiovascular surgery 20011201 |
| Endothelin blockade in angiotensin II hypertension: prevention and treatment studies in the rat. | Clinical and experimental pharmacology & physiology 20011201 |
| General pharmacokinetic model for drugs exhibiting target-mediated drug disposition. | Journal of pharmacokinetics and pharmacodynamics 20011201 |
| Renal tubulointerstitial damage caused by persistent proteinuria is attenuated in AT1-deficient mice: role of endothelin-1. | The American journal of pathology 20011101 |
| Effects of the endothelin receptor antagonist bosentan on cardiac performance during porcine endotoxin shock. | Acta anaesthesiologica Scandinavica 20011101 |
| Rationale and perspective of endothelin-1 antagonism in acute heart failure. | Journal of cardiovascular pharmacology 20011101 |
| [Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomized placebo-controlled study]. | Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 20011101 |
| Endothelin receptor blockade in congestive heart failure. | Circulation 20011030 |
| Report from the 93rd Cardiovascular and Renal Drugs Advisory Committee Meeting, August 9-10, 2001. | Circulation 20011009 |
| Endothelin-receptor antagonists in pulmonary hypertension. | Lancet (London, England) 20011006 |
| Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebo-controlled study. | Lancet (London, England) 20011006 |
| Endothelin mediates phospholipase C stimulation in the proximal tubule during initiation of compensatory renal growth in adult rats. | Croatian medical journal 20011001 |
| Chronic blockade of endothelin receptors improves ischemia-induced angiogenesis in rat hindlimbs through activation of vascular endothelial growth factor-no pathway. | Arteriosclerosis, thrombosis, and vascular biology 20011001 |
| Endothelin receptor blockade and nitric oxide bioactivity. | Cardiovascular research 20011001 |
| Endogenous endothelins mediate increased acidification in remnant kidneys. | Journal of the American Society of Nephrology : JASN 20010901 |
| Endothelin involvement in respiratory centre activity. | Prostaglandins, leukotrienes, and essential fatty acids 20010901 |
| Report From the 93rd Cardiovascular and Renal Drugs Advisory Committee Meeting, August 9-10, 2001. | Circulation 20010828 |
| Endothelin receptor blockade reduces ventricular dysfunction and injury after reoxygenation. | The Annals of thoracic surgery 20010801 |
| The underreporting of results and possible mechanisms of 'negative' drug trials in patients with chronic heart failure. | International journal of cardiology 20010801 |
| Improvement of respiratory function by bosentan during endotoxic shock in the pig. | Prostaglandins, leukotrienes, and essential fatty acids 20010801 |
| Differential effects of angiotensin II versus endothelin-1 inhibitions in hypertrophic left ventricular myocardium during transition to heart failure. | Circulation 20010731 |
| Effects of the endothelin receptor antagonist Bosentan on ischaemia/reperfusion injury in rat skeletal muscle. | European journal of pharmacology 20010713 |
| Endothelin mediates some of the renal actions of acutely administered angiotensin II. | Hypertension (Dallas, Tex. : 1979) 20010701 |
| Long-term endothelin receptor blockade improves cardiovascular function in diabetes. | American journal of hypertension 20010701 |
| New pharmacological strategies for the treatment of heart failure. | Current opinion in investigational drugs (London, England : 2000) 20010701 |
| Aminoethyl-isothiourea inhibits the increase in plasma endothelin-1 caused by serogroup A streptococci and prolongs survival in rat peritoneal sepsis. | Shock (Augusta, Ga.) 20010601 |
| Endothelium-dependent relaxation in response to low concentrations of bradykinin is enhanced by phosphoramidon, bosentan and BQ-123 in bovine coronary arteries in vitro. | Japanese journal of pharmacology 20010601 |
| Effect of angiotensin II receptor antagonist and endothelin receptor antagonist on nitroglycerin tolerance in rats. | Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih 20010601 |
| Acute endothelin a receptor blockade in heart failure. | Circulation 20010508 |
| Neurogenic inflammation in the context of migraine. | Microscopy research and technique 20010501 |
| Combined angiotensin and endothelin receptor blockade attenuates adverse cardiac remodeling post-myocardial infarction in the rat: possible role of transforming growth factor beta(1). | Journal of molecular and cellular cardiology 20010501 |
| Endothelin receptor antagonists in congestive heart failure: a new therapeutic principle for the future? | Journal of the American College of Cardiology 20010501 |
| Blockade of the renin-angiotensin and endothelin systems on progressive renal injury. | Hypertension (Dallas, Tex. : 1979) 20010501 |
| Update in pharmacologic treatment of hypertension. | Cardiology clinics 20010501 |
| Effect of endothelin antagonism on the production of cytokines in eosinophilic airway inflammation. | American journal of physiology. Lung cellular and molecular physiology 20010401 |
| Role of endothelin and vasopressin in DOCA-salt hypertension. | British journal of pharmacology 20010401 |
| Role of endothelin in the circulatory changes associated with small bowel strangulation obstruction in pigs: effects of the endothelin receptor antagonist bosentan. | The Journal of surgical research 20010401 |
| The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions. | Clinical pharmacology and therapeutics 20010401 |
| Chronic bosentan treatment improves renal artery vascular function in diabetes. | Journal of hypertension 20010401 |
| The timing of endothelin and nitric oxide inhibition affects survival in a mice model of septic shock. | European journal of pharmacology 20010302 |
| A new era in the treatment of primary pulmonary hypertension. | Heart (British Cardiac Society) 20010301 |
| Subarachnoid haemorrhage-induced sympathoexcitation in rats is reversed by bosentan or sodium nitroprusside. | Clinical and experimental pharmacology & physiology 20010301 |
| Augmentation of endothelial function by endothelin antagonism in human saphenous vein conduits. | Journal of neurosurgery 20010201 |
| Endothelin antagonism uncovers insulin-mediated vasorelaxation in vitro and in vivo. | Hypertension (Dallas, Tex. : 1979) 20010201 |
| Regression of renal vascular fibrosis by endothelin receptor antagonism. | Hypertension (Dallas, Tex. : 1979) 20010201 |
| Role of endothelin and isoprostanes in slow pressor responses to angiotensin II. | Hypertension (Dallas, Tex. : 1979) 20010201 |
| Endothelin receptor blockade improves endothelial function in human internal mammary arteries. | Cardiovascular research 20010101 |
| Endothelin receptor antagonist prevents parathyroid cell proliferation of low calcium diet-induced hyperparathyroidism in rats. | Endocrinology 20010101 |
| Combined blockade of endothelin-1 and thromboxane A(2) receptors against postischaemic contractile dysfunction in rat hearts. | British journal of pharmacology 20010101 |
| Important role for endothelins in acute hepatic ischemia/reperfusion injury. | Journal of investigative surgery : the official journal of the Academy of Surgical Research 20010101 |
| Bosentan, an endothelin antagonist, augments hepatic graft function by reducing graft circulatory impairment following ischemia/reperfusion injury. | Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20010101 |
| The loop diuretic torasemide interferes with endothelin-1 actions in the aorta of hypertensive rats. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20010101 |
| Pharmacological regulation of postischemic sinusoidal diameters in rats--a new approach for reducing hepatic ischemia/reperfusion injury. | Clinical hemorheology and microcirculation 20010101 |
| Allosteric inhibition of endothelin ETA receptors by 3, 5-dibromosalicylic acid. | Molecular pharmacology 20001201 |
| Differential effects of the mixed ET(A)/ET(B)-receptor antagonist bosentan on endothelin-induced bronchoconstriction, vasoconstriction and prostacyclin release. | Naunyn-Schmiedeberg's archives of pharmacology 20000801 |
| Angiotensin II receptor blockade unmasks a depressor response to endothelin antagonists in rats. | Fundamental & clinical pharmacology 20000101 |
| Bosentan reduces blood pressure and the target-organ damage induced by a high-fructose diet in rats. | Journal of hypertension 19991201 |
| Adrenocorticotrophic hormone-induced hypertension in the rat: effects of the endothelin antagonist bosentan. | Clinical and experimental pharmacology & physiology 19990801 |
| Endothelin antagonism with bosentan: a review of potential applications. | Journal of molecular medicine (Berlin, Germany) 19990401 |
| Pharmacological inactivation of the endothelin type A receptor in the early chick embryo: a model of mispatterning of the branchial arch derivatives. | Development (Cambridge, England) 19981201 |
| Acute effects of an endothelin-1 receptor antagonist bosentan at different stages of heart failure in conscious dogs. | Cardiovascular research 19980901 |
| The effect of an endothelin-receptor antagonist, bosentan, on blood pressure in patients with essential hypertension. Bosentan Hypertension Investigators. | The New England journal of medicine 19980319 |
| Blood pressure and vascular effects of endothelin blockade in chronic nitric oxide-deficient hypertension. | Hypertension (Dallas, Tex. : 1979) 19970301 |
| Endothelin antagonism in end-organ damage of spontaneously hypertensive rats. Comparison with angiotensin-converting enzyme inhibition and calcium antagonism. | Hypertension (Dallas, Tex. : 1979) 19960901 |
| Blocking both type A and B endothelin receptors in the kidney attenuates renal injury and prolongs survival in rats with remnant kidney. | American journal of kidney diseases : the official journal of the National Kidney Foundation 19960301 |
| [Demonstration of a vasopressor role of endogenous endothelin after inhibition of nitric oxide synthesis in rats]. | Archives des maladies du coeur et des vaisseaux 19950801 |
| The role of endothelin in experimental cerebral vasospasm. | Neurosurgery 19950701 |
| Effect of chronic treatment of adult spontaneously hypertensive rats with an endothelin receptor antagonist. | Hypertension (Dallas, Tex. : 1979) 19950401 |
| In vivo evidence of an endothelin-induced vasopressor tone after inhibition of nitric oxide synthesis in rats. | Circulation 19950201 |
| Effect of a nonselective endothelin antagonist on vascular remodeling in deoxycorticosterone acetate-salt hypertensive rats. Evidence for a role of endothelin in vascular hypertrophy. | Hypertension (Dallas, Tex. : 1979) 19940801 |
| Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist. | The Journal of pharmacology and experimental therapeutics 19940701 |
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