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Home > Pyridines > 119477-85-9
119477-85-9 | 1,5-Hexanediol, 6-[6-[(1E,3R,5Z)-3-hydroxy-1,5-undecadien-1-yl]-2-pyridinyl]-, (5S)-
CAS No: 119477-85-9 Catalog No: AG000IV5 MDL No:
Product Description
Catalog Number:
AG000IV5
Chemical Name:
1,5-Hexanediol, 6-[6-[(1E,3R,5Z)-3-hydroxy-1,5-undecadien-1-yl]-2-pyridinyl]-, (5S)-
CAS Number:
119477-85-9
Molecular Formula:
C22H35NO3
Molecular Weight:
361.5182
IUPAC Name:
(5S)-6-[6-[(1E,3R,5Z)-3-hydroxyundeca-1,5-dienyl]pyridin-2-yl]hexane-1,5-diol
InChI:
InChI=1S/C22H35NO3/c1-2-3-4-5-6-7-13-21(25)16-15-19-11-10-12-20(23-19)18-22(26)14-8-9-17-24/h6-7,10-12,15-16,21-22,24-26H,2-5,8-9,13-14,17-18H2,1H3/b7-6-,16-15+/t21-,22+/m1/s1
InChI Key:
JNBOAUIJLDEICX-LJCAKPRGSA-N
SMILES:
CCCCC/C=C\C[C@H](/C=C/c1cccc(n1)C[C@H](CCCCO)O)O
Properties
Complexity:
384
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
2
Defined Bond Stereocenter Count:
2
Exact Mass:
361.262g/mol
Formal Charge:
0
Heavy Atom Count:
26
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
361.526g/mol
Monoisotopic Mass:
361.262g/mol
Rotatable Bond Count:
14
Topological Polar Surface Area:
73.6A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.1
Literature
| Title | Journal |
|---|---|
| Leukotriene B(4) receptors BLT1 and BLT2 are involved in interleukin-8 production in human neutrophils induced by Trichomonas vaginalis-derived secretory products. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20120201 |
| Leukotriene synthases and the receptors induced by peripheral nerve injury in the spinal cord contribute to the generation of neuropathic pain. | Glia 20100401 |
| 4-Hydroxynonenal enhances MMP-9 production in murine macrophages via 5-lipoxygenase-mediated activation of ERK and p38 MAPK. | Toxicology and applied pharmacology 20100115 |
| Leukotriene B4, administered via intracerebroventricular injection, attenuates the antigen-induced asthmatic response in sensitized guinea pigs. | Journal of neuroinflammation 20100101 |
| Intracerebroventricular injection of leukotriene B4 attenuates antigen-induced asthmatic response via BLT1 receptor stimulating HPA-axis in sensitized rats. | Respiratory research 20100101 |
| Relationship between calcium release and NADPH oxidase inhibition in human neutrophils. | Biochemical and biophysical research communications 20090619 |
| 15-lipoxygenase metabolites play an important role in the development of a T-helper type 1 allergic inflammation induced by double-stranded RNA. | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20090601 |
| Involvement of the BLT2 receptor in the itch-associated scratching induced by 12-(S)-lipoxygenase products in ICR mice. | British journal of pharmacology 20080701 |
| Endothelium-dependent vascular responses induced by leukotriene B4. | Prostaglandins & other lipid mediators 20070501 |
| Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation. | Journal of immunology (Baltimore, Md. : 1950) 20070315 |
| Homologous desensitisation of the mouse leukotriene B4 receptor involves protein kinase C-mediated phosphorylation of serine 127. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101 |
| Leukotrienes modulate cytokine release from dendritic cells. | Immunology 20051201 |
| Increased 5-lipoxygenase expression and induction of apoptosis by its inhibitors in esophageal cancer: a potential target for prevention. | Carcinogenesis 20050401 |
| Exploring the pharmacology of the leukotriene B4 receptor BLT1, without the confounding effects of BLT2. | European journal of pharmacology 20040919 |
| Evidence that 5-lipoxygenase and acetylated cyclooxygenase 2-derived eicosanoids regulate leukocyte-endothelial adherence in response to aspirin. | British journal of pharmacology 20030801 |
| Modulation of leukotriene B4 receptor-1 expression by dexamethasone: potential mechanism for enhanced neutrophil survival. | Journal of immunology (Baltimore, Md. : 1950) 20020401 |
| A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization. | The Journal of biological chemistry 20001229 |
| Characterization of the cloned guinea pig leukotriene B4 receptor: comparison to its human orthologue. | European journal of pharmacology 19990910 |
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