200,000+ products from a single source!
sales@angenechem.com
118290-27-0 | 11H-Pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide, N-[2-[2-[(dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-, methanesulfonate (1:1)
CAS No: 118290-27-0 Catalog No: AG0034FQ MDL No:MFCD00884624
Product Description
Catalog Number:
AG0034FQ
Chemical Name:
11H-Pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide, N-[2-[2-[(dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-, methanesulfonate (1:1)
CAS Number:
118290-27-0
Molecular Formula:
C28H42N6O5S
Molecular Weight:
574.7353
MDL Number:
MFCD00884624
IUPAC Name:
N-[2-[2-[(dipropylamino)methyl]piperidin-1-yl]ethyl]-6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide;methanesulfonic acid
InChI:
InChI=1S/C27H38N6O2.CH4O3S/c1-3-16-31(17-4-2)20-21-10-7-8-18-32(21)19-15-29-27(35)33-24-13-6-5-11-22(24)26(34)30-23-12-9-14-28-25(23)33;1-5(2,3)4/h5-6,9,11-14,21H,3-4,7-8,10,15-20H2,1-2H3,(H,29,35)(H,30,34);1H3,(H,2,3,4)
InChI Key:
LBXOPAJGAXATCZ-UHFFFAOYSA-N
SMILES:
CS(=O)(=O)O.CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC
Properties
Complexity:
777
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
574.294g/mol
Formal Charge:
0
Heavy Atom Count:
40
Hydrogen Bond Acceptor Count:
8
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
574.741g/mol
Monoisotopic Mass:
574.294g/mol
Rotatable Bond Count:
9
Topological Polar Surface Area:
144A^2
Undefined Atom Stereocenter Count:
1
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| Early changes in M2 muscarinic acetylcholine receptors (mAChRs) induced by sarin intoxication may be linked to long lasting neurological effects. | Neurotoxicology 20180301 |
| Near-complete adaptation of the PRiMA knockout to the lack of central acetylcholinesterase. | Journal of neurochemistry 20120901 |
| Muscarinic receptor/G-protein coupling is reduced in the dorsomedial striatum of cognitively impaired aged rats. | Behavioural brain research 20120201 |
| Decreased kainate receptors in the hippocampus of apolipoprotein D knockout mice. | Progress in neuro-psychopharmacology & biological psychiatry 20100317 |
| Regional changes in the cholinergic system in mice lacking monoamine oxidase A. | Brain research bulletin 20090330 |
| Asymmetrical distributions of muscarinic receptor binding in the hippocampus of female rats. | European journal of pharmacology 20080707 |
| The effects of mercury on muscarinic cholinergic receptor subtypes (M1 and M2) in captive mink. | Neurotoxicology 20080301 |
| Olanzapine treatment decreases the density of muscarinic M2 receptors in the dorsal vagal complex of rats. | Progress in neuro-psychopharmacology & biological psychiatry 20070509 |
| Insect muscarinic acetylcholine receptor: pharmacological and toxicological profiles of antagonists and agonists. | Journal of agricultural and food chemistry 20070321 |
| Alterations of muscarinic and GABA receptor binding in the posterior cingulate cortex in schizophrenia. | Progress in neuro-psychopharmacology & biological psychiatry 20070130 |
| Cholinergic receptor subtypes in the olfactory bulbectomy model of depression. | Brain research bulletin 20060130 |
| Allosteric modulators and selective agonists of muscarinic receptors. | Journal of molecular neuroscience : MN 20060101 |
| Decreased density of muscarinic receptors in the superior temporal gyrusin schizophrenia. | Journal of neuroscience research 20050915 |
| Muscarinic M2 and M4 receptors in anterior cingulate cortex: relation to neuropsychiatric symptoms in dementia with Lewy bodies. | Behavioural brain research 20050620 |
| M2/M4 muscarinic receptor binding in the anterior cingulate cortex in schizophrenia and mood disorders. | Brain research bulletin 20050515 |
| A pentylenetetrazole-induced generalized seizure in early life enhances the efficacy of muscarinic receptor coupling to G-protein in hippocampus and neocortex of adult rat. | The European journal of neuroscience 20050401 |
| Smoking during early pregnancy affects the expression pattern of both nicotinic and muscarinic acetylcholine receptors in human first trimester brainstem and cerebellum. | Neuroscience 20050101 |
| Maternal exposure to nicotine and chlorpyrifos, alone and in combination, leads to persistently elevated expression of glial fibrillary acidic protein in the cerebellum of the offspring in late puberty. | Archives of toxicology 20040801 |
| Development of a new type of allosteric modulator of muscarinic receptors: hybrids of the antagonist AF-DX 384 and the hexamethonio derivative W84. | Journal of medicinal chemistry 20040603 |
| Co-exposure to pyridostigmine bromide, DEET, and/or permethrin causes sensorimotor deficit and alterations in brain acetylcholinesterase activity. | Pharmacology, biochemistry, and behavior 20040201 |
| Chlorpyrifos exposure during neurulation: cholinergic synaptic dysfunction and cellular alterations in brain regions at adolescence and adulthood. | Brain research. Developmental brain research 20040131 |
| Differential modulation of muscarinic receptors in the rat brain by repeated exposure to methyl parathion. | The Journal of toxicological sciences 20031201 |
| Up-regulation of spinal muscarinic receptors and increased antinociceptive effect of intrathecal muscarine in diabetic rats. | The Journal of pharmacology and experimental therapeutics 20031101 |
| Muscarinic receptors in basal ganglia in dementia with Lewy bodies, Parkinson's disease and Alzheimer's disease. | Journal of chemical neuroanatomy 20030301 |
| Loss of muscarinic M4 receptors in hippocampus of Alzheimer patients. | Brain research 20030117 |
| The colon-selective spasmolytic otilonium bromide inhibits muscarinic M(3) receptor-coupled calcium signals in isolated human colonic crypts. | British journal of pharmacology 20021201 |
| Comparative distribution of binding of the muscarinic receptor ligands pirenzepine, AF-DX 384, (R,R)-I-QNB and (R,S)-I-QNB to human brain. | Journal of chemical neuroanatomy 20020901 |
| Effect of subchronic administration of metrifonate, rivastigmine and donepezil on brain acetylcholine in aged F344 rats. | Journal of neural transmission (Vienna, Austria : 1996) 20020701 |
| Chronic treatments with tacrine and (-)-nicotine induce different changes of nicotinic and muscarinic acetylcholine receptors in the brain of aged rat. | Journal of neural transmission (Vienna, Austria : 1996) 20020301 |
| Estrogen effects on object memory and cholinergic receptors in young and old female mice. | Neurobiology of aging 20020101 |
| Locomotor and sensorimotor performance deficit in rats following exposure to pyridostigmine bromide, DEET, and permethrin, alone and in combination. | Toxicological sciences : an official journal of the Society of Toxicology 20010401 |
| Pharmacology, distribution and development of muscarinic acetylcholine receptor subtypes in the optic tectum of Rana pipiens. | Neuroscience 20010101 |
| Binding and functional selectivity of himbacine for cloned and neuronal muscarinic receptors. | The Journal of pharmacology and experimental therapeutics 19921101 |
| Binding of [3H]AF-DX 384 to cloned and native muscarinic receptors. | The Journal of pharmacology and experimental therapeutics 19911101 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.