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117467-28-4 | Cefditoren pivoxil
CAS No: 117467-28-4 Catalog No: AG003OQB MDL No:MFCD00933166
Product Description
Catalog Number:
AG003OQB
Chemical Name:
Cefditoren pivoxil
CAS Number:
117467-28-4
Molecular Formula:
C25H28N6O7S3
Molecular Weight:
620.7208
MDL Number:
MFCD00933166
IUPAC Name:
2,2-dimethylpropanoyloxymethyl (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(Z)-2-(4-methyl-1,3-thiazol-5-yl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
InChI:
InChI=1S/C25H28N6O7S3/c1-12-15(41-10-27-12)7-6-13-8-39-21-17(29-19(32)16(30-36-5)14-9-40-24(26)28-14)20(33)31(21)18(13)22(34)37-11-38-23(35)25(2,3)4/h6-7,9-10,17,21H,8,11H2,1-5H3,(H2,26,28)(H,29,32)/b7-6-,30-16-/t17-,21-/m1/s1
InChI Key:
AFZFFLVORLEPPO-UVYJNCLZSA-N
SMILES:
CO/N=C(/c1csc(n1)N)\C(=O)N[C@@H]1C(=O)N2[C@@H]1SCC(=C2C(=O)OCOC(=O)C(C)(C)C)/C=C\c1scnc1C
UNII:
78THA212DH
Properties
Complexity:
1160
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
2
Defined Bond Stereocenter Count:
2
Exact Mass:
620.118g/mol
Formal Charge:
0
Heavy Atom Count:
41
Hydrogen Bond Acceptor Count:
14
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
620.714g/mol
Monoisotopic Mass:
620.118g/mol
Rotatable Bond Count:
12
Topological Polar Surface Area:
257A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.7
Literature
| Title | Journal |
|---|---|
| Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). | PLoS computational biology 20111201 |
| [Antibiotic therapy against acute tonsillopharyngitis in children due to group A beta-hemolytic streptococci: comparison of clinical efficacy, the bactericidal effects, and effects on oral flora between cefditoren pivoxil for 5 days and amoxicillin for 10 days]. | The Japanese journal of antibiotics 20110601 |
| [Evaluation of the safety and efficacy of cefditoren pivoxil fine granules for pediatric use in pediatric patients with laryngopharyngitis and tonsillitis caused by Streptococcus pyogenes]. | The Japanese journal of antibiotics 20100801 |
| [Evaluation of the safety and efficacy of cefditoren pivoxil fine granules for pediatric use in pediatric patients with acute otitis media]. | The Japanese journal of antibiotics 20100601 |
| [Pulmonary abscess due to Leuconostoc species in an immunocompetent patient]. | Archivos de bronconeumologia 20090901 |
| Effect of fluoroquinolones on body temperature of mice. | The Journal of antimicrobial chemotherapy 20081201 |
| Efficacy of cefditoren pivoxil and amoxicillin/clavulanate in the treatment of pediatric patients with acute bacterial rhinosinusitis in Thailand: a randomized, investigator-blinded, controlled trial. | Clinical therapeutics 20081001 |
| Efficient and eco-friendly preparation of 4-methyl-5-formyl-thiazole. | Molecules (Basel, Switzerland) 20080421 |
| [A multicenter study of 7-day cefditoren pivoxil treatment for group A streptococcal infection]. | The Japanese journal of antibiotics 20071001 |
| Carnitine-associated encephalopathy caused by long-term treatment with an antibiotic containing pivalic acid. | Pediatrics 20070901 |
| The efficacy of cefditoren pivoxil in the treatment of lower respiratory tract infections, with a focus on the per-pathogen bacteriologic response in infections caused by Streptococcus pneumoniae and Haemophilus influenzae: a pooled analysis of seven clinical trials. | Clinical therapeutics 20061201 |
| [Cefditoren pivoxil: A new oral cephalosporin for skin, soft tissue and respiratory tract infections]. | Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 20060901 |
| Effects of sugar ester and hydroxypropyl methylcellulose on the physicochemical stability of amorphous cefditoren pivoxil in aqueous suspension. | International journal of pharmaceutics 20050216 |
| A study of the differences between two amorphous spray-dried samples of cefditoren pivoxil which exhibited different physical stabilities. | International journal of pharmaceutics 20050131 |
| Spotlight on cefditoren pivoxil in bacterial infections. | Treatments in respiratory medicine 20050101 |
| Precision and detection limit of quality test for amorphous drug in powder X-ray diffractometry. | International journal of pharmaceutics 20040928 |
| Changes in surface properties by granulation and physicochemical stability of granulated amorphous cefditoren pivoxil with additives. | International journal of pharmaceutics 20040806 |
| The use of inverse gas chromatography to assess the acid-base contributions to surface energies of cefditoren pivoxil and methacrylate copolymers and possible links to instability. | International journal of pharmaceutics 20040319 |
| Determination of the changes in surface energetics of cefditoren pivoxil as a consequence of processing induced disorder and equilibration to different relative humidities. | International journal of pharmaceutics 20040109 |
| Cefditoren pivoxil: a review of its use in the treatment of bacterial infections. | Drugs 20040101 |
| Impact on carnitine homeostasis of short-term treatment with the pivalate prodrug cefditoren pivoxil. | Clinical pharmacology and therapeutics 20030401 |
| [Efficacy and safety of cefditoren pivoxil in treatment of respiratory infections, a clinical study]. | Zhonghua yi xue za zhi 20030310 |
| Cefditoren pivoxil versus cefpodoxime proxetil for community-acquired pneumonia: results of a multicenter, prospective, randomized, double-blind study. | Clinical therapeutics 20021101 |
| A comparison of cefditoren pivoxil and amoxicillin/ clavulanate in the treatment of community-acquired pneumonia: a multicenter, prospective, randomized, investigator-blinded, parallel-group study. | Clinical therapeutics 20021101 |
| New drugs 2002, part III. | Nursing 20020701 |
| Cefditoren pivoxil. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20020301 |
| Antibiotic approval. | The Nurse practitioner 20020201 |
| Spectracef. New cephalosporin antibiotic approved. | Nursing 20020201 |
| Cefditoren pivoxil. | Drugs 20020101 |
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