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117414-74-1 | 2-Piperazinecarboxylic acid, 4-[(2E)-3-phosphono-2-propenyl]-, (2R)-
CAS No: 117414-74-1 Catalog No: AG000E9S MDL No:
Product Description
Catalog Number:
AG000E9S
Chemical Name:
2-Piperazinecarboxylic acid, 4-[(2E)-3-phosphono-2-propenyl]-, (2R)-
CAS Number:
117414-74-1
Molecular Formula:
C8H15N2O5P
Molecular Weight:
250.1889
IUPAC Name:
(2R)-4-[(E)-3-phosphonoprop-2-enyl]piperazine-2-carboxylic acid
InChI:
InChI=1S/C8H15N2O5P/c11-8(12)7-6-10(4-2-9-7)3-1-5-16(13,14)15/h1,5,7,9H,2-4,6H2,(H,11,12)(H2,13,14,15)/b5-1+/t7-/m1/s1
InChI Key:
VZXMZMJSGLFKQI-ABVWVHJUSA-N
SMILES:
OC(=O)[C@@H]1NCCN(C1)C/C=C/P(=O)(O)O
UNII:
7LYU6ZF84G
Properties
Complexity:
326
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
1
Defined Bond Stereocenter Count:
1
Exact Mass:
250.072g/mol
Formal Charge:
0
Heavy Atom Count:
16
Hydrogen Bond Acceptor Count:
7
Hydrogen Bond Donor Count:
4
Isotope Atom Count:
0
Molecular Weight:
250.191g/mol
Monoisotopic Mass:
250.072g/mol
Rotatable Bond Count:
4
Topological Polar Surface Area:
110A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-7
Literature
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|---|---|
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| NMDA NR2 receptors participate in CCK-induced reduction of food intake and hindbrain neuronal activation. | Brain research 20090417 |
| Blockade of hindbrain NMDA receptors containing NR2 subunits increases sucrose intake. | American journal of physiology. Regulatory, integrative and comparative physiology 20090401 |
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| Effects of modulators of N-methyl-D-aspartate receptor-mediated neurotransmission on diazepam discrimination in rats. | Life sciences 20040528 |
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| Inactivation of amino acid receptors in medullary reticular formation modulates and suppresses ingestion and rejection responses in the awake rat. | American journal of physiology. Regulatory, integrative and comparative physiology 20030701 |
| Involvement of glutamate receptors within the central nucleus of the amygdala in naloxone-precipitated morphine withdrawal-induced conditioned place aversion in rats. | Japanese journal of pharmacology 20020401 |
| The competitive NMDA receptor antagonist CPPene stimulates NREM sleep and eating in rats. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20020301 |
| Effects of the NMDA receptor antagonist, D-CPPene, on sensitization to the operant decrement produced by naloxone in morphine-treated rats. | Behavioural pharmacology 20010401 |
| NMDA receptor antagonists do not block the development of sensitization of catalepsy, but make its expression state-dependent. | Behavioural pharmacology 20010401 |
| Thermal sterilization of heat-sensitive products using high-temperature short-time sterilization. | Journal of pharmaceutical sciences 20010301 |
| Evaluation of HIV-1 Tat induced neurotoxicity in rat cortical cell culture. | Journal of neurovirology 20010201 |
| N6-cyclohexyladenosine and 3-(2-carboxypiperazine-4-yl)-1-propenyl-1-phosphonic acid enhance the effect of antiepileptic drugs against induced seizures in mice. | Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20010101 |
| Effects of some excitatory amino acid antagonists on imipenem-induced seizures in DBA/2 mice. | Brain research 19950206 |
| [Effects of antagonists of NMDA receptor on methamphetamine-induced decrease in the dopamine uptake sites in the rat striatum and on the behavioral sensitization]. | [Hokkaido igaku zasshi] The Hokkaido journal of medical science 19930501 |
| Competitive and noncompetitive N-methyl-D-aspartate antagonists protect dopaminergic and serotonergic neurotoxicity produced by methamphetamine in various brain regions. | Journal of neural transmission. General section 19930101 |
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