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116679-83-5

116679-83-5 | Silanol, 1-cyclohexyl-1-(4-fluorophenyl)-1-[3-(1-piperidinyl)propyl]-

CAS No: 116679-83-5 Catalog No: AG000CZ5 MDL No:

Product Description

Catalog Number:
AG000CZ5
Chemical Name:
Silanol, 1-cyclohexyl-1-(4-fluorophenyl)-1-[3-(1-piperidinyl)propyl]-
CAS Number:
116679-83-5
Molecular Formula:
C20H32FNOSi
Molecular Weight:
349.5581
IUPAC Name:
cyclohexyl-(4-fluorophenyl)-hydroxy-(3-piperidin-1-ylpropyl)silane
InChI:
InChI=1S/C20H32FNOSi/c21-18-10-12-20(13-11-18)24(23,19-8-3-1-4-9-19)17-7-16-22-14-5-2-6-15-22/h10-13,19,23H,1-9,14-17H2
InChI Key:
ZNSZQJHTFRQUPD-UHFFFAOYSA-N
SMILES:
Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O

Properties

Complexity:
363  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
349.224g/mol
Formal Charge:
0
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
349.565g/mol
Monoisotopic Mass:
349.224g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
23.5A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0

Literature

Title Journal
Muscarinic receptor subtypes involved in urothelium-derived relaxatory effects in the inflamed rat urinary bladder. Autonomic neuroscience : basic & clinical 20120925
Contractions of the mouse prostate elicited by acetylcholine are mediated by M(3) muscarinic receptors. The Journal of pharmacology and experimental therapeutics 20111201
Functional characterization of the muscarinic receptors involved in endothelium-dependent relaxation in isolated canine uterine artery. Journal of veterinary pharmacology and therapeutics 20090401
Acetylcholine release by human colon cancer cells mediates autocrine stimulation of cell proliferation. American journal of physiology. Gastrointestinal and liver physiology 20080901
Aging-induced decrease of cholinergic response and calcium sensitivity on rat jejunum contractions. The journals of gerontology. Series A, Biological sciences and medical sciences 20070301
Regulation of bladder muscarinic receptor subtypes by experimental pathologies. Autonomic & autacoid pharmacology 20060701
Distribution and function of muscarinic receptor subtypes in the ovine submandibular gland. Journal of applied physiology (Bethesda, Md. : 1985) 20060401
Pharmacological characterization of muscarinic receptor subtypes mediating vasoconstriction of human umbilical vein. British journal of pharmacology 20060301
Midbrain muscarinic receptor mechanisms underlying regulation of mesoaccumbens and nigrostriatal dopaminergic transmission in the rat. The European journal of neuroscience 20050401
Comparison of the antimuscarinic action of p-fluorohexahydrosiladifenidol in ileal and tracheal smooth muscle. The Journal of pharmacology and experimental therapeutics 20050201
Contractile effect of acetylcholine on isolated isthmic segment of fallopian tubes. Methods and findings in experimental and clinical pharmacology 20040301
Contractile effect of acetylcholine on isolated ampullar segment of Fallopian tubes. Pharmacological research 20040101
Aging-related alterations in the contractile responses to acetylcholine, muscarinic cholinoceptors and cholinesterase activities in jejunum and colon of the male Fischer 344 rats. Experimental gerontology 20040101
The cholinomimetic agent bethanechol activates IK(ACh) in feline atrial myocytes. Naunyn-Schmiedeberg's archives of pharmacology 20031001
Antagonistic effects of antimuscarinic drugs on alpha 1-adrenoceptors. Naunyn-Schmiedeberg's archives of pharmacology 20021001
Interaction between muscarinic receptor subtype signal transduction pathways mediating bladder contraction. American journal of physiology. Regulatory, integrative and comparative physiology 20020901
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. The Journal of biological chemistry 20020419
Acetylcholine-induced contractions in the perforating branch of the human internal mammary artery: protective role of the vascular endothelium. Pharmacology 20020401
Muscarinic receptor subtypes mediate stimulatory and paradoxical inhibitory effects on an insulin-secreting beta cell line. Biochimica et biophysica acta 20020115
Receptor binding studies of soft anticholinergic agents. AAPS pharmSci 20011201
Muscarinic receptors control K+ secretion in inner ear strial marginal cells. The Journal of membrane biology 20010801
The antinociceptive and sedative effects of carbachol and oxycodone administered into brainstem pontine reticular formation and spinal subarachnoid space in rats. Anesthesia and analgesia 20010501
Muscarinic receptor subtypes mediating vasorelaxation of the perforating branch of the human internal mammary artery. Pharmacology 20010101
M3 muscarinic receptor activation of a delayed rectifier potassium current in canine atrial myocytes. Life sciences 19990101
Stimulation of cyclic AMP accumulation and phosphoinositide hydrolysis by M3 muscarinic receptors in the rat peripheral lung. Biochemical pharmacology 19960823
Assessment of the muscarinic receptor subtypes involved in pilocarpine-induced seizures in mice. Neuroscience letters 19940227
Cloning of the rat M3, M4 and M5 muscarinic acetylcholine receptor genes by the polymerase chain reaction (PCR) and the pharmacological characterization of the expressed genes. Life sciences 19920101

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