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1166-01-4 | 2-Pyrazinecarboxamide, 3,5-diamino-6-chloro-N-[[[(3,4-dichlorophenyl)methyl]amino]iminomethyl]-
CAS No: 1166-01-4 Catalog No: AG000CUL MDL No:
Product Description
Catalog Number:
AG000CUL
Chemical Name:
2-Pyrazinecarboxamide, 3,5-diamino-6-chloro-N-[[[(3,4-dichlorophenyl)methyl]amino]iminomethyl]-
CAS Number:
1166-01-4
Molecular Formula:
C13H12Cl3N7O
Molecular Weight:
388.6397
IUPAC Name:
3,5-diamino-6-chloro-N-[N'-[(3,4-dichlorophenyl)methyl]carbamimidoyl]pyrazine-2-carboxamide
InChI:
InChI=1S/C13H12Cl3N7O/c14-6-2-1-5(3-7(6)15)4-20-13(19)23-12(24)8-10(17)22-11(18)9(16)21-8/h1-3H,4H2,(H4,17,18,22)(H3,19,20,23,24)
InChI Key:
OSHKWEFWXCCNJR-UHFFFAOYSA-N
SMILES:
O=C(c1nc(Cl)c(nc1N)N)NC=NNCc1ccc(c(c1)Cl)Cl
Properties
Complexity:
481
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
387.017g/mol
Formal Charge:
0
Heavy Atom Count:
24
Hydrogen Bond Acceptor Count:
6
Hydrogen Bond Donor Count:
4
Isotope Atom Count:
0
Molecular Weight:
388.637g/mol
Monoisotopic Mass:
387.017g/mol
Rotatable Bond Count:
4
Topological Polar Surface Area:
145A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3
Literature
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|---|---|
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| Dual inhibition of sodium-mediated proton and calcium efflux triggers non-apoptotic cell death in malignant gliomas. | Brain research 20101202 |
| Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay. | Antimicrobial agents and chemotherapy 20100901 |
| Modulation of neuroprotective effect of ischemic post-conditioning by dichlorobenzamil a Na(+)/Ca(2+) exchanger inhibitor in mice. | Biological & pharmaceutical bulletin 20100101 |
| Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
| Studies on cerebral protection of digoxin against ischemia/reperfusion injury in mice. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20090401 |
| Stimulation of large-conductance Ca2+-activated K+ channels by the Na+/Ca2+ exchanger inhibitor dichlorobenzamil in cultured human umbilical vein endothelial cells and mouse aortic smooth muscle cells. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20090301 |
| Endothelin-1 decreases [Ca2+]i via Na+/Ca2+ exchanger in CHO cells stably expressing endothelin ETA receptor. | European journal of pharmacology 20070702 |
| Mineralisation of 2,6-dichlorobenzamide (BAM) in dichlobenil-exposed soils and isolation of a BAM-mineralising Aminobacter sp. | Environmental pollution (Barking, Essex : 1987) 20061101 |
| Intrasperm Ca2+ modulation and human ejaculated sperm viability: influence of miconazole, clotrimazole and loperamide. | The Journal of pharmacy and pharmacology 20060801 |
| External bioenergy-induced increases in intracellular free calcium concentrations are mediated by Na+/Ca2+ exchanger and L-type calcium channel. | Molecular and cellular biochemistry 20050301 |
| Acute effects of glucose and insulin on vascular endothelium. | Diabetologia 20041201 |
| Amiloride kills malignant glioma cells independent of its inhibition of the sodium-hydrogen exchanger. | The Journal of pharmacology and experimental therapeutics 20040701 |
| Physiological role of the sodium-calcium exchanger in tracheal smooth muscle of guinea pig. | Journal of muscle research and cell motility 20040101 |
| Peroxynitrite-induced cardiac depression: role of myofilament desensitization and cGMP pathway. | Cardiovascular research 20031101 |
| Activation of apical K+ conductances by muscarinic receptor stimulation in rat distal colon: fast and slow components. | The Journal of membrane biology 20031001 |
| Effects of extracellular Na+ and Ca2+ ions and Ca2+ channel modulators on the cell-associated activity of 99mTc-MIBI and 99mTc-tetrofosmin in tumour cells. | Nuclear medicine communications 20030201 |
| Amiloride derivatives are potent blockers of KATP channels. | Naunyn-Schmiedeberg's archives of pharmacology 20011001 |
| Interaction between store-operated non-selective cation channels and the Na(+)-Ca(2+) exchanger during secretion in the rat colon. | Experimental physiology 20010701 |
| Effect of extracellular Mg(2+) on ROS and Ca(2+) accumulation during reoxygenation of rat cardiomyocytes. | American journal of physiology. Heart and circulatory physiology 20010101 |
| Interdependence between sodium transport, external chloride, and sodium/calcium exchanger in the isolated skin of the Rana pipiens. | The Journal of experimental zoology 20010101 |
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