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1156-19-0 | Benzenesulfonamide, N-[[(hexahydro-1H-azepin-1-yl)amino]carbonyl]-4-methyl-
CAS No: 1156-19-0 Catalog No: AG000G8X MDL No:MFCD00083504
Product Description
Catalog Number:
AG000G8X
Chemical Name:
Benzenesulfonamide, N-[[(hexahydro-1H-azepin-1-yl)amino]carbonyl]-4-methyl-
CAS Number:
1156-19-0
Molecular Formula:
C14H21N3O3S
Molecular Weight:
311.3998
MDL Number:
MFCD00083504
IUPAC Name:
1-(azepan-1-yl)-3-(4-methylphenyl)sulfonylurea
InChI:
InChI=1S/C14H21N3O3S/c1-12-6-8-13(9-7-12)21(19,20)16-14(18)15-17-10-4-2-3-5-11-17/h6-9H,2-5,10-11H2,1H3,(H2,15,16,18)
InChI Key:
OUDSBRTVNLOZBN-UHFFFAOYSA-N
SMILES:
O=C(NS(=O)(=O)c1ccc(cc1)C)NN1CCCCCC1
EC Number:
214-588-3
UNII:
9LT1BRO48Q
Properties
Complexity:
431
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
311.13g/mol
Formal Charge:
0
Heavy Atom Count:
21
Hydrogen Bond Acceptor Count:
4
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
311.4g/mol
Monoisotopic Mass:
311.13g/mol
Rotatable Bond Count:
3
Topological Polar Surface Area:
86.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.5
Literature
| Title | Journal |
|---|---|
| Epac2: a sulfonylurea receptor? | Biochemical Society transactions 20120201 |
| The management of type 2 diabetic patients with hypoglycaemic agents. | ISRN endocrinology 20120101 |
| Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). | PLoS computational biology 20111201 |
| Effects of Sulfonylureas on Peroxisome Proliferator-Activated Receptor γ Activity and on Glucose Uptake by Thiazolidinediones. | Diabetes & metabolism journal 20110801 |
| Glycemic control, complications, and death in older diabetic patients: the diabetes and aging study. | Diabetes care 20110601 |
| Primary language, income and the intensification of anti-glycemic medications in managed care: the (TRIAD) study. | Journal of general internal medicine 20110501 |
| A predictive ligand-based Bayesian model for human drug-induced liver injury. | Drug metabolism and disposition: the biological fate of chemicals 20101201 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| Glucose biosensors: an overview of use in clinical practice. | Sensors (Basel, Switzerland) 20100101 |
| Accuracy of Veterans Affairs databases for diagnoses of chronic diseases. | Preventing chronic disease 20091001 |
| The second-meal phenomenon in type 2 diabetes. | Diabetes care 20090701 |
| A review of exenatide as adjunctive therapy in patients with type 2 diabetes. | Drug design, development and therapy 20090101 |
| Prediction of pharmacological and xenobiotic responses to drugs based on time course gene expression profiles. | PloS one 20090101 |
| Risk of cardiovascular disease and all cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: retrospective cohort study using UK general practice research database. | BMJ (Clinical research ed.) 20090101 |
| Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. | Journal of medicinal chemistry 20081113 |
| Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysis. | Diabetes care 20081101 |
| Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. | Nature chemical biology 20080501 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach. | Journal of medicinal chemistry 20050407 |
| Effects of sulfonylureas, alpha-endosulfine counterparts, on glomerulosclerosis in type 1 and type 2 models of diabetes. | Kidney international 20050201 |
| Cardiovascular risk factors associated with insulin resistance: effects of oral antidiabetic agents. | American journal of cardiovascular drugs : drugs, devices, and other interventions 20050101 |
| Detection of anti-diabetics in equine plasma and urine by liquid chromatography-tandem mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041105 |
| Efficacy of sulfonylureas with insulin in type 2 diabetes mellitus. | The Annals of pharmacotherapy 20031101 |
| Selection of drugs to test the specificity of the Tg.AC assay by screening for induction of the gadd153 promoter in vitro. | Toxicological sciences : an official journal of the Society of Toxicology 20030801 |
| Barriers to self-monitoring of blood glucose among adults with diabetes in an HMO: a cross sectional study. | BMC health services research 20030101 |
| [A 50-year history of new drugs in Japan-the development and progress of anti-diabetic drugs and the epidemiological aspects of diabetes mellitus]. | Yakushigaku zasshi 20030101 |
| Screening, library-assisted identification and validated quantification of oral antidiabetics of the sulfonylurea-type in plasma by atmospheric pressure chemical ionization liquid chromatography-mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020615 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| The structure and function of the ATP-sensitive K+ channel in insulin-secreting pancreatic beta-cells. | Journal of molecular endocrinology 19990401 |
| Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor. | Science (New York, N.Y.) 19951117 |
| Oral hypoglycemic agents in the treatment of type II diabetes. | American family physician 19931101 |
| Transketolase abnormality in tolazamide-induced Wernicke's encephalopathy. | Neurology 19861101 |
| A case of chronic liver disease due to tolazamide. | Gastroenterology 19850701 |
| Wernicke's encephalopathy induced by tolazamide. | The New England journal of medicine 19830908 |
| The effect of chlorpropamide hyponatremia on mental status in a nursing home population. | The Journal of family practice 19830501 |
| Potentiation of insulin action by a sulfonylurea in primary cultures of hepatocytes from normal and diabetic rats. | Diabetes 19830301 |
| Tolazamide-induced cholestasis. | Southern medical journal 19800801 |
| Reduction of the severity of nephropathy in aging Fischer 344 rats treated with analogs of arylsulfonyluria. | Toxicology and applied pharmacology 19790701 |
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