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Home > Fluorides > 115453-82-2
CAS No: 115453-82-2 Catalog No: AG000G0A MDL No:MFCD00467588
Title | Journal |
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Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system. | Toxicology in vitro : an international journal published in association with BIBRA 20130901 |
Increase of human CYP1B1 activities by acidic phospholipids and kinetic deuterium isotope effects on CYP1B1 substrate oxidation. | Journal of biochemistry 20121101 |
Characterization of inhibitory effects of perfluorooctane sulfonate on human hepatic cytochrome P450 isoenzymes: focusing on CYP2A6. | Chemico-biological interactions 20111115 |
Polymorphic variants of cytochrome P450 2B6 (CYP2B6.4-CYP2B6.9) exhibit altered rates of metabolism for bupropion and efavirenz: a charge-reversal mutation in the K139E variant (CYP2B6.8) impairs formation of a functional cytochrome p450-reductase complex. | The Journal of pharmacology and experimental therapeutics 20110901 |
Structural analysis of mammalian cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene: insight into partial enzymatic activity. | Biochemistry 20110607 |
Comparison of in vitro metabolism of ticlopidine by human cytochrome P450 2B6 and rabbit cytochrome P450 2B4. | Drug metabolism and disposition: the biological fate of chemicals 20110301 |
Cytochrome P450-mediated hepatic metabolism of new fluorescent substrates in cats and dogs. | Journal of veterinary pharmacology and therapeutics 20101201 |
A quantitative high-throughput 96-well plate fluorescence assay for mechanism-based inactivators of cytochromes P450 exemplified using CYP2B6. | Nature protocols 20100901 |
Functional characterization of 26 CYP2B6 allelic variants (CYP2B6.2-CYP2B6.28, except CYP2B6.22). | Pharmacogenetics and genomics 20100701 |
Beta sheet 2-alpha helix C loop of cytochrome P450 reductase serves as a docking site for redox partners. | Biochimica et biophysica acta 20100601 |
Long-term cultivation of HepG2 liver cells encapsulated in alginate hydrogels: a study of cell viability, morphology and drug metabolism. | Toxicology in vitro : an international journal published in association with BIBRA 20100601 |
Effects of cytochrome P450 inhibitors on the biotransformation of fluorogenic substrates by adult male rat liver microsomes and cDNA-expressed rat cytochrome P450 isoforms. | Toxicological sciences : an official journal of the Society of Toxicology 20100201 |
Functional expression in Bacillus subtilis of mammalian NADPH-cytochrome P450 oxidoreductase and its spore-display. | Protein expression and purification 20090101 |
Amino acid positions 69-132 of UGT1A9 are involved in the C-glucuronidation of phenylbutazone. | Archives of biochemistry and biophysics 20081001 |
Identification and analysis of conserved sequence motifs in cytochrome P450 family 2. Functional and structural role of a motif 187RFDYKD192 in CYP2B enzymes. | The Journal of biological chemistry 20080801 |
Rational engineering of human cytochrome P450 2B6 for enhanced expression and stability: importance of a Leu264->Phe substitution. | Molecular pharmacology 20071101 |
Peroxynitrite inactivation of human cytochrome P450s 2B6 and 2E1: heme modification and site-specific nitrotyrosine formation. | Chemical research in toxicology 20071101 |
Mutation of a single residue (K262R) in P450 2B6 leads to loss of mechanism-based inactivation by phencyclidine. | Drug metabolism and disposition: the biological fate of chemicals 20070801 |
Re-engineering cytochrome P450 2B11dH for enhanced metabolism of several substrates including the anti-cancer prodrugs cyclophosphamide and ifosfamide. | Archives of biochemistry and biophysics 20070215 |
Structure-activity relationship and elucidation of the determinant factor(s) responsible for the mechanism-based inactivation of cytochrome P450 2B6 by substituted phenyl diaziridines. | Drug metabolism and disposition: the biological fate of chemicals 20061201 |
Investigation of the role of cytochrome P450 2B4 active site residues in substrate metabolism based on crystal structures of the ligand-bound enzyme. | Archives of biochemistry and biophysics 20061101 |
Metabolism of efavirenz and 8-hydroxyefavirenz by P450 2B6 leads to inactivation by two distinct mechanisms. | The Journal of pharmacology and experimental therapeutics 20060701 |
Biochemical analysis of a chlorfenapyr-selected resistant strain of Tetranychus urticae Koch. | Pest management science 20060501 |
Improvement in the expression of CYP2B6 by co-expression with molecular chaperones GroES/EL in Escherichia coli. | Protein expression and purification 20060401 |
Determination of CYP2B6 component of 7-ethoxy-4-trifluoromethylcoumarin O-deethylation activity in human liver microsomes. | Methods in molecular biology (Clifton, N.J.) 20060101 |
Expression and activity of CYP2E1 in circulating lymphocytes are not altered in diabetic individuals. | Pharmacological research 20050601 |
Directed evolution of mammalian cytochrome P450 2B1: mutations outside of the active site enhance the metabolism of several substrates, including the anticancer prodrugs cyclophosphamide and ifosfamide. | The Journal of biological chemistry 20050520 |
Comparative acaricide susceptibility and detoxifying enzyme activities in field-collected resistant and susceptible strains of Tetranychus urticae. | Pest management science 20050501 |
Functional role of residues in the helix B' region of cytochrome P450 2B1. | Archives of biochemistry and biophysics 20050301 |
Effects of ionic strength on the functional interactions between CYP2B4 and CYP1A2. | Biochemistry 20050222 |
EpoK, a cytochrome P450 involved in biosynthesis of the anticancer agents epothilones A and B. Substrate-mediated rescue of a P450 enzyme. | Biochemistry 20041123 |
Identification of amino acid residues involved in the inactivation of cytochrome P450 2B1 by two acetylenic compounds: the role of three residues in nonsubstrate recognition Sites. | The Journal of pharmacology and experimental therapeutics 20041001 |
Metabolism of human cytochrome P450 marker substrates in mouse: a strain and gender comparison. | Xenobiotica; the fate of foreign compounds in biological systems 20040901 |
Mutagenesis and molecular dynamics suggest structural and functional roles for residues in the N-terminal portion of the cytochrome P450 2B1 I helix. | Archives of biochemistry and biophysics 20040315 |
Mechanistic studies with N-benzyl-1-aminobenzotriazole-inactivated CYP2B1: differential effects on the metabolism of 7-ethoxy-4-(trifluoromethyl)coumarin, testosterone, and benzphetamine. | Archives of biochemistry and biophysics 20040315 |
Threonine-205 in the F helix of p450 2B1 contributes to androgen 16 beta-hydroxylation activity and mechanism-based inactivation. | The Journal of pharmacology and experimental therapeutics 20030801 |
Functional characterization of cytochrome P450 2B6 allelic variants. | Drug metabolism and disposition: the biological fate of chemicals 20030401 |
Comparison of substrate metabolism by cytochromes P450 2B1, 2B4, and 2B6: relationship of heme spin state, catalysis, and the effects of cytochrome b5. | Journal of inorganic biochemistry 20030115 |
Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes. | Archives of biochemistry and biophysics 20030101 |
Analysis of differential substrate selectivities of CYP2B6 and CYP2E1 by site-directed mutagenesis and molecular modeling. | The Journal of pharmacology and experimental therapeutics 20030101 |
Substrate routes to the buried active site may vary among cytochromes P450: mutagenesis of the F-G region in P450 2B1. | Chemical research in toxicology 20021101 |
Effect of tamoxifen on the enzymatic activity of human cytochrome CYP2B6. | The Journal of pharmacology and experimental therapeutics 20020601 |
Combined three-dimensional quantitative structure-activity relationship analysis of cytochrome P450 2B6 substrates and protein homology modeling. | Drug metabolism and disposition: the biological fate of chemicals 20020101 |
Effects of plant-derived phenols on rat liver cytochrome P450 2B1 activity. | Anticancer research 20020101 |
A truncation of 2B subfamily cytochromes P450 yields increased expression levels, increased solubility, and decreased aggregation while retaining function. | Archives of biochemistry and biophysics 20011101 |
Examination of purported probes of human CYP2B6. | Pharmacogenetics 19970601 |
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