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1154-25-2 | 2-Pyrazinecarboxamide, 3-amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-
CAS No: 1154-25-2 Catalog No: AG000FXV MDL No:
Product Description
Catalog Number:
AG000FXV
Chemical Name:
2-Pyrazinecarboxamide, 3-amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-
CAS Number:
1154-25-2
Molecular Formula:
C11H18ClN7O
Molecular Weight:
299.7599
IUPAC Name:
3-amino-6-chloro-N-(diaminomethylidene)-5-[ethyl(propan-2-yl)amino]pyrazine-2-carboxamide
InChI:
InChI=1S/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)
InChI Key:
QDERNBXNXJCIQK-UHFFFAOYSA-N
SMILES:
NN=CNC(=O)c1nc(Cl)c(nc1N)N(C(C)C)CC
Properties
Complexity:
372
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
299.126g/mol
Formal Charge:
0
Heavy Atom Count:
20
Hydrogen Bond Acceptor Count:
5
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
299.763g/mol
Monoisotopic Mass:
299.126g/mol
Rotatable Bond Count:
4
Topological Polar Surface Area:
137A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.3
Literature
| Title | Journal |
|---|---|
| Functional analysis and in vitro correction of splicing FAH mutations causing tyrosinemia type I. | Clinical genetics 20140801 |
| Blockade of peripheral and spinal Na+/H+ exchanger increases formalin-induced long-lasting mechanical allodynia and hyperalgesia in rats. | Brain research 20120926 |
| Anti-proliferative effect of atrial natriuretic peptide on colorectal cancer cells: evidence for an Akt-mediated cross-talk between NHE-1 activity and Wnt/β-catenin signaling. | Biochimica et biophysica acta 20120601 |
| Performance of cell-penetrating peptide-linked polymers physically mixed with poorly membrane-permeable molecules on cell membranes. | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20120501 |
| The Na+/H+ exchanger NHE1, but not the Na+, HCO3(-) cotransporter NBCn1, regulates motility of MCF7 breast cancer cells expressing constitutively active ErbB2. | Cancer letters 20120428 |
| Intracellular pH regulation in unstimulated Calliphora salivary glands is Na+ dependent and requires V-ATPase activity. | The Journal of experimental biology 20120415 |
| Comparative characterization of Na+ transport in Cyprinodon variegatus variegatus and Cyprinodon variegatus hubbsi: a model species complex for studying teleost invasion of freshwater. | The Journal of experimental biology 20120401 |
| Flow cytometry analysis reveals a decrease in intracellular sodium during sperm capacitation. | Journal of cell science 20120115 |
| Uptake of ricinB-quantum dot nanoparticles by a macropinocytosis-like mechanism. | Journal of nanobiotechnology 20120101 |
| Ammonia excretion via Rhcg1 facilitates Na⁺ uptake in larval zebrafish, Danio rerio, in acidic water. | American journal of physiology. Regulatory, integrative and comparative physiology 20111101 |
| Ebola virus enters host cells by macropinocytosis and clathrin-mediated endocytosis. | The Journal of infectious diseases 20111101 |
| The Ebola virus glycoprotein mediates entry via a non-classical dynamin-dependent macropinocytic pathway. | Virology 20111025 |
| Mechanism of ribonuclease A endocytosis: analogies to cell-penetrating peptides. | Biochemistry 20111004 |
| Presynaptic regulation of quantal size: K+/H+ exchange stimulates vesicular glutamate transport. | Nature neuroscience 20111001 |
| Bicarbonate, NBCe1, NHE, and carbonic anhydrase activity enhance lactate-H+ transport in bovine corneal endothelium. | Investigative ophthalmology & visual science 20111001 |
| Discovery, synthesis, and biological evaluation of novel SMN protein modulators. | Journal of medicinal chemistry 20110922 |
| Effect of aldosterone on the amplification of oncolytic vaccinia virus in human cancer lines. | The Korean journal of hepatology 20110901 |
| Role of the spinal Na+/H+ exchanger in formalin-induced nociception. | Neuroscience letters 20110821 |
| Plasma-accessible carbonic anhydrase at the tissue of a teleost fish may greatly enhance oxygen delivery: in vitro evidence in rainbow trout, Oncorhynchus mykiss. | The Journal of experimental biology 20110715 |
| Decoupling of the catalytic and transport activities of complex I from Rhodothermus marinus by sodium/proton antiporter inhibitor. | ACS chemical biology 20110520 |
| Dissection of the influenza A virus endocytic routes reveals macropinocytosis as an alternative entry pathway. | PLoS pathogens 20110301 |
| Expression and modulation of Na(+) /H(+) exchanger 1 gene in hepatocellular carcinoma: A potential therapeutic target. | Journal of gastroenterology and hepatology 20110201 |
| Sodium hydrogen exchanger as a mediator of hydrostatic edema-induced intestinal contractile dysfunction. | Surgery 20110101 |
| The cardioprotective effect of brief acidic reperfusion after ischemia in perfused rat hearts is not mimicked by inhibition of the Na(+)/H(+) exchanger NHE1. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101 |
| Contribution of the amiloride-sensitive component and the Na+/H+ exchanger to renal responsiveness to vasoconstrictors. | Pharmacology 20110101 |
| Ammonia uptake in Manduca sexta midgut is mediated by an amiloride sensitive cation/proton exchanger: Transport studies and mRNA expression analysis of NHE7, 9, NHE8, and V-ATPase (subunit D). | Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20101201 |
| Effect of metabolic acidosis on neonatal proximal tubule acidification. | American journal of physiology. Regulatory, integrative and comparative physiology 20101101 |
| Inhibition of Na(+)/H(+) exchanger 1 by 5-(N-ethyl-N-isopropyl) amiloride reduces hypoxia-induced hepatocellular carcinoma invasion and motility. | Cancer letters 20100928 |
| Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay. | Antimicrobial agents and chemotherapy 20100901 |
| Larvae of the midge Chironomus riparius possess two distinct mechanisms for ionoregulation in response to ion-poor conditions. | American journal of physiology. Regulatory, integrative and comparative physiology 20100901 |
| Cellular entry of ebola virus involves uptake by a macropinocytosis-like mechanism and subsequent trafficking through early and late endosomes. | PLoS pathogens 20100901 |
| [Comparison of mechanisms and cellular uptake of cell-penetrating peptide on different cell lines]. | Yao xue xue bao = Acta pharmaceutica Sinica 20100901 |
| Ouabain stimulates Na-K-ATPase through a sodium/hydrogen exchanger-1 (NHE-1)-dependent mechanism in human kidney proximal tubule cells. | American journal of physiology. Renal physiology 20100701 |
| A role for Na+/H+ exchangers and intracellular pH in regulating vitamin C-driven electron transport across the plasma membrane. | The Biochemical journal 20100513 |
| AE2 Cl-/HCO3- exchanger is required for normal cAMP-stimulated anion secretion in murine proximal colon. | American journal of physiology. Gastrointestinal and liver physiology 20100401 |
| Ammonium-dependent sodium uptake in mitochondrion-rich cells of medaka (Oryzias latipes) larvae. | American journal of physiology. Cell physiology 20100201 |
| A clathrin independent macropinocytosis-like entry mechanism used by bluetongue virus-1 during infection of BHK cells. | PloS one 20100101 |
| pH regulating transporters in neurons from various chemosensitive brainstem regions in neonatal rats. | American journal of physiology. Regulatory, integrative and comparative physiology 20091101 |
| Bicarbonate transport by the human pancreatic ductal cell line HPAF. | Pancreas 20091101 |
| Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
| Protein transport in human cells mediated by covalently and noncovalently conjugated arginine-rich intracellular delivery peptides. | Peptides 20090901 |
| Blockade of epithelial sodium channels improves sperm motility in asthenospermia patients. | International journal of andrology 20090801 |
| Role of the sodium hydrogen exchanger in maitotoxin-induced cell death in cultured rat cortical neurons. | Toxicon : official journal of the International Society on Toxinology 20090801 |
| Nhe1 is a luminal Na+/H+ exchanger in mouse choroid plexus and is targeted to the basolateral membrane in Ncbe/Nbcn2-null mice. | American journal of physiology. Cell physiology 20090601 |
| Identification of the Na+/H+ exchanger 1 in dorsal root ganglion and spinal cord: its possible role in inflammatory nociception. | Neuroscience 20090421 |
| Amiloride derivatives induce apoptosis by depleting ER Ca(2+) stores in vascular endothelial cells. | British journal of pharmacology 20090401 |
| The Na+/H+ exchanger modulates long-term potentiation in rat hippocampal slices. | Naunyn-Schmiedeberg's archives of pharmacology 20090301 |
| Activation of Na+/H+ and K+/H+ exchange by calyculin A in Amphiuma tridactylum red blood cells: implications for the control of volume-induced ion flux activity. | American journal of physiology. Cell physiology 20081101 |
| Luminal hydrochloric acid stimulates rapid transepithelial ion fluxes in rodent esophageal stratified squamous epithelium. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20080901 |
| Transport activities involved in intracellular pH recovery following acid and alkali challenges in rat brain microvascular endothelial cells. | Pflugers Archiv : European journal of physiology 20080801 |
| Late expression of Na+/H+ exchanger 1 (NHE1) and neuroprotective effects of NHE inhibitor in the gerbil hippocampal CA1 region induced by transient ischemia. | Experimental neurology 20080801 |
| Increased colonic sodium absorption in rats with chronic renal failure is partially mediated by AT1 receptor agonism. | American journal of physiology. Gastrointestinal and liver physiology 20080801 |
| Lidocaine increases intracellular sodium concentration through a Na+-H+ exchanger in an identified Lymnaea neuron. | Anesthesia and analgesia 20080501 |
| Cellular uptake of cell-penetrating peptides pVEC and transportan in plants. | Journal of peptide science : an official publication of the European Peptide Society 20080401 |
| Impaired acid secretion in cortical collecting duct intercalated cells from H-K-ATPase-deficient mice: role of HKalpha isoforms. | American journal of physiology. Renal physiology 20080301 |
| Oxidative stress and the genomic regulation of aldosterone-stimulated NHE1 activity in SHR renal proximal tubular cells. | Molecular and cellular biochemistry 20080301 |
| 5-(N-ethyl-N-isopropyl)-amiloride enhances SMN2 exon 7 inclusion and protein expression in spinal muscular atrophy cells. | Annals of neurology 20080101 |
| Targeting splicing in spinal muscular atrophy. | Annals of neurology 20080101 |
| Mitochondrial Complex I superoxide production is attenuated by uncoupling. | The international journal of biochemistry & cell biology 20080101 |
| Troglitazone induced cytosolic acidification via extracellular signal-response kinase activation and mitochondrial depolarization: complex I proton pumping regulates ammoniagenesis in proximal tubule-like LLC-PK1 cells. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20080101 |
| Enhanced Na+/H+ exchange activity contributes to the pathogenesis of muscular dystrophy via involvement of P2 receptors. | The American journal of pathology 20071101 |
| The alpha2-adrenergic receptor agonist UK 14,304 inhibits secretin-stimulated ductal secretion by downregulation of the cAMP system in bile duct-ligated rats. | American journal of physiology. Cell physiology 20071001 |
| Bicarbonate-dependent pH(i) regulation by chondrocytes within the superficial zone of bovine articular cartilage. | Journal of cellular physiology 20070901 |
| Lysophosphatidylserine increases membrane potentials in rat C6 glioma cells. | Archives of pharmacal research 20070901 |
| NHE1 inhibition by amiloride- and benzoylguanidine-type compounds. Inhibitor binding loci deduced from chimeras of NHE1 homologues with endogenous differences in inhibitor sensitivity. | The Journal of biological chemistry 20070706 |
| Loss of calcineurin homologous protein-1 in chicken B lymphoma DT40 cells destabilizes Na+/H+ exchanger isoform-1 protein. | American journal of physiology. Cell physiology 20070701 |
| Apoptosis induction is associated with decreased NHE1 expression in neonatal unilateral ureteric obstruction. | BJU international 20070701 |
| pH-dependent toxicity of sulphur mustard in vitro. | Toxicology and applied pharmacology 20070615 |
| Delay of acute intracellular pH recovery after acidosis decreases endothelial cell activation. | Journal of cellular physiology 20070501 |
| The role played by endocytosis in albumin-induced secretion of TGF-beta1 by proximal tubular epithelial cells. | American journal of physiology. Renal physiology 20070501 |
| Reduction of intracellular pH inhibits the expression of VEGF in K562 cells after targeted inhibition of the Na+/H+ exchanger. | Leukemia research 20070401 |
| Inhibition of lipopolysaccharide-induced prostaglandin E2 production and inflammation by the Na+/H+ exchanger inhibitors. | The Journal of pharmacology and experimental therapeutics 20070401 |
| An improved in vitro model of human intestinal follicle-associated epithelium to study nanoparticle transport by M cells. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20070401 |
| A vacuolar-type H+-ATPase and a Na+/H+ exchanger contribute to intracellular pH regulation in cockroach salivary ducts. | The Journal of experimental biology 20070401 |
| Vitamin C transport and SVCT1 transporter expression in chick renal proximal tubule cells in culture. | Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20070301 |
| Role of Na+/H+ exchanger in the pathogenesis of ischemic acute renal failure in mice. | Journal of cardiovascular pharmacology 20070301 |
| Colony-stimulating factor-1 increases osteoclast intracellular pH and promotes survival via the electroneutral Na/HCO3 cotransporter NBCn1. | Endocrinology 20070201 |
| Apical electrolyte concentration modulates barrier function and tight junction protein localization in bovine mammary epithelium. | American journal of physiology. Cell physiology 20070101 |
| Positive inotropic effects of carbon monoxide-releasing molecules (CO-RMs) in the isolated perfused rat heart. | British journal of pharmacology 20061201 |
| Effects of Na+/H+ exchanger inhibitors on subcellular localisation of endocytic organelles and intracellular dynamics of protein transduction domains HIV-TAT peptide and octaarginine. | Journal of controlled release : official journal of the Controlled Release Society 20061128 |
| Transporters involved in regulation of intracellular pH in primary cultured rat brain endothelial cells. | The Journal of physiology 20061101 |
| NHE2 is the main apical NHE in mouse colonic crypts but an alternative Na+-dependent acid extrusion mechanism is upregulated in NHE2-null mice. | American journal of physiology. Gastrointestinal and liver physiology 20061001 |
| Relative contribution of V-H+ATPase and NA+/H+ exchanger to bicarbonate reabsorption in proximal convoluted tubules of old rats. | Aging cell 20061001 |
| Molecular characterization of sodium/proton exchanger 3 (NHE3) from the yellow fever vector, Aedes aegypti. | The Journal of experimental biology 20060901 |
| Cytotoxic mechanisms of Zn2+ and Cd2+ involve Na+/H+ exchanger (NHE) activation by ROS. | Aquatic toxicology (Amsterdam, Netherlands) 20060720 |
| Chronic high glucose inhibits albumin reabsorption by lysosomal alkalinization in cultured porcine proximal tubular epithelial cells (LLC-PK1). | Diabetes research and clinical practice 20060601 |
| Effects of bafilomycin A1, a vacuolar type H+ ATPase inhibitor, on the thermosensitivity of a human pancreatic cancer cell line. | International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20060601 |
| Involvement of Na+/H+ exchanger in the calcium signaling in epimastigotes of Trypanosoma cruzi. | FEBS letters 20060515 |
| Control of intracellular trafficking of ICAM-1-targeted nanocarriers by endothelial Na+/H+ exchanger proteins. | American journal of physiology. Lung cellular and molecular physiology 20060501 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| The effect of acidosis on adenosine release from cultured rat forebrain neurons. | Brain research 20060412 |
| Axial flow modulates proximal tubule NHE3 and H-ATPase activities by changing microvillus bending moments. | American journal of physiology. Renal physiology 20060201 |
| Involvement of the Na+/H+ exchanger in membrane phosphatidylserine exposure during human platelet activation. | Biochimica et biophysica acta 20060201 |
| PGE2-induced apoptotic cell death in K562 human leukaemia cells. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20060101 |
| Vectorial bicarbonate transport by Capan-1 cells: a model for human pancreatic ductal secretion. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20060101 |
| Differential contribution of troponin I phosphorylation sites to the endothelin-modulated contractile response. | The Journal of biological chemistry 20051216 |
| Mechanisms for nongenomic and genomic effects of aldosterone on Na+/H+ exchange in vascular smooth muscle cells. | Journal of hypertension 20051201 |
| Properties of motility in Bacillus subtilis powered by the H+-coupled MotAB flagellar stator, Na+-coupled MotPS or hybrid stators MotAS or MotPB. | Journal of molecular biology 20050916 |
| Na+/H+ exchanger activity is increased in doxorubicin-resistant human colon cancer cells and its modulation modifies the sensitivity of the cells to doxorubicin. | International journal of cancer 20050720 |
| Dual modes of 5-(N-ethyl-N-isopropyl)amiloride modulation of apical dipeptide uptake in the human small intestinal epithelial cell line Caco-2. | Cellular and molecular life sciences : CMLS 20050701 |
| Zinc and 17beta-estradiol induce modifications in Na+/H+ exchanger and pyruvate kinase activity through protein kinase C in isolated mantle/gonad cells of Mytilus galloprovincialis. | Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20050701 |
| An IkappaB-beta COOH terminal region protein is essential for the proliferation of CHO cells under acidic stress. | Journal of cellular physiology 20050401 |
| Muscarinic activation of Na+-dependent ion transporters and modulation by bicarbonate in rat submandibular gland acinus. | American journal of physiology. Gastrointestinal and liver physiology 20050401 |
| Heat-induced changes in intracellular Na+, pH and bioenergetic status in superfused RIF-1 tumour cells determined by 23Na and 31P magnetic resonance spectroscopy. | International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20050301 |
| Impaired regulation of pH homeostasis by oxidative stress in rat brain capillary endothelial cells. | Cellular and molecular neurobiology 20050201 |
| Different contributions of endothelin-A and endothelin-B receptors in postischemic cardiac dysfunction and norepinephrine overflow in rat hearts. | Circulation 20050125 |
| Catecholamine clearance from alveolar spaces of rat and human lungs. | Respiration; international review of thoracic diseases 20050101 |
| Novel antiinflammatory vascular benefits of systemic and stent-based delivery of ethylisopropylamiloride. | Circulation 20041214 |
| Acidification reduces mitochondrial calcium uptake in rat cardiac mitochondria. | American journal of physiology. Heart and circulatory physiology 20041201 |
| Rapid nongenomic effects of 3,5,3'-triiodo-L-thyronine on the intracellular pH of L-6 myoblasts are mediated by intracellular calcium mobilization and kinase pathways. | Endocrinology 20041201 |
| Inhibition of bicarbonate reabsorption in the rat proximal tubule by activation of luminal P2Y1 receptors. | American journal of physiology. Renal physiology 20041001 |
| Endocardial endothelium modulates subendocardial pH(i) of rabbit papillary muscles: role of transendothelial HCO(3)(-) transport. | Cardiovascular research 20040901 |
| Differential regulation of Na+/H+ exchange isoform activities by enteropathogenic E. coli in human intestinal epithelial cells. | American journal of physiology. Gastrointestinal and liver physiology 20040801 |
| Activation of the apical Na+/H+ exchanger NHE3 by formate: a basis of enhanced fluid and electrolyte reabsorption by formate in the kidney. | American journal of physiology. Renal physiology 20040801 |
| Intracellular acidification by inhibition of the Na+/H+-exchanger leads to caspase-independent death of cerebellar granule neurons resembling paraptosis. | Cell death and differentiation 20040701 |
| CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion. | The Journal of biological chemistry 20040625 |
| Inhibition of carcinogen-bioactivating cytochrome P450 1 isoforms by amiloride derivatives. | Biochemical pharmacology 20040501 |
| Cadmium induces both pyruvate kinase and Na+/H+ exchanger activity through protein kinase C mediated signal transduction, in isolated digestive gland cells of Mytilus galloprovincialis (L.). | The Journal of experimental biology 20040401 |
| Stimulation of NHE3 in OKP cells by an autocrine mechanism. | Nephron. Experimental nephrology 20040101 |
| Bidirectional regulation of renal cortical Na+,K+-ATPase by protein kinase C. | Acta biochimica Polonica 20040101 |
| Involvement of Na+/H+ exchanger in desmopressin-induced platelet procoagulant response. | Acta biochimica Polonica 20040101 |
| Sodium and chloride transport in soft water and hard water acclimated zebrafish (Danio rerio). | Biochimica et biophysica acta 20031230 |
| Demonstration of a functional apical sodium hydrogen exchanger in isolated rat gastric glands. | American journal of physiology. Gastrointestinal and liver physiology 20031201 |
| The Na+/H+ exchange inhibitor: a new therapeutic approach for hepatic ischemia injury in rats. | Transplantation proceedings 20031201 |
| Critical role for NHE1 in intracellular pH regulation in pancreatic acinar cells. | American journal of physiology. Gastrointestinal and liver physiology 20031101 |
| Na+ overload during ischemia and reperfusion in rat hearts: comparison of the Na+/H+ exchange blockers EIPA, cariporide and eniporide. | Molecular and cellular biochemistry 20030801 |
| [3H]-DA release evoked by low pH medium and internal H+ accumulation in rat hypothalamic synaptosomes: involvement of calcium ions. | Neurochemistry international 20030701 |
| Ethyl isopropyl amiloride inhibits smooth muscle cell proliferation and migration by inducing apoptosis and antagonizing urokinase plasminogen activator activity. | Canadian journal of physiology and pharmacology 20030701 |
| Non-genomic regulation of intermediate conductance potassium channels by aldosterone in human colonic crypt cells. | Gut 20030601 |
| PTH stimulates a Cl(-)-dependent and EIPA-sensitive current in chick proximal tubule cells in culture. | American journal of physiology. Renal physiology 20030501 |
| Mutations of Arg440 and Gly455/Gly456 oppositely change pH sensing of Na+/H+ exchanger 1. | The Journal of biological chemistry 20030404 |
| Differential sensitivity of human monocytes and macrophages to ANP: a role of intracellular pH on reactive oxygen species production through the phospholipase involvement. | Journal of leukocyte biology 20030401 |
| Inhibition of erythrocyte cation channels and apoptosis by ethylisopropylamiloride. | Naunyn-Schmiedeberg's archives of pharmacology 20030401 |
| Role of Na+/H+ exchanger in acetylcholine-mediated pulmonary artery contraction of spontaneously hypertensive rats. | European journal of pharmacology 20030319 |
| Antifibrogenic effects of canrenone, an antialdosteronic drug, on human hepatic stellate cells. | Gastroenterology 20030201 |
| Effect of protein kinase C activation on Na+-H+ exchange in erythrocytes of frog Rana temporaria. | Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20030101 |
| Intracellular pH regulation in U937 human monocytes: roles of V-ATPase and Na+/H+ exchange. | Immunobiology 20030101 |
| Endolymphatic sodium homeostasis by Reissner's membrane. | Neuroscience 20030101 |
| Electrophysiological properties of the Plasmodium Falciparum-induced cation conductance of human erythrocytes. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20030101 |
| [Activation of the Na/H exchange in erythrocytes of the frog Rana ridibunda]. | Zhurnal evoliutsionnoi biokhimii i fiziologii 20030101 |
| Dependence of Plasmodium falciparum in vitro growth on the cation permeability of the human host erythrocyte. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20030101 |
| Sodium-proton exchange in crayfish. | Biochimica et biophysica acta 20021113 |
| Apical H(+)/base transporters mediating bicarbonate absorption and pH(i) regulation in the OMCD. | American journal of physiology. Renal physiology 20021101 |
| NHE blockade inhibits chemokine production and NF-kappaB activation in immunostimulated endothelial cells. | American journal of physiology. Cell physiology 20020801 |
| Loss of cell volume regulation during metabolic inhibition in renal epithelial cells (A6): role of intracellular pH. | American journal of physiology. Cell physiology 20020801 |
| Glucose stimulates O2 consumption, NOS, and Na/H exchange in diabetic rat proximal tubules. | American journal of physiology. Renal physiology 20020801 |
| Cytostatic potential of novel agents that inhibit the regulation of intracellular pH. | British journal of cancer 20020715 |
| Apical Na+/H+ exchange near the base of mouse colonic crypts. | American journal of physiology. Cell physiology 20020701 |
| Expression and function of sodium transporters in two opossum kidney cell clonal sublines. | American journal of physiology. Renal physiology 20020701 |
| Na+/H+ exchanger blockade inhibits enterocyte inflammatory response and protects against colitis. | American journal of physiology. Gastrointestinal and liver physiology 20020701 |
| Mitochondrial damage during ischemia determines post-ischemic contractile dysfunction in perfused rat heart. | Journal of molecular and cellular cardiology 20020701 |
| Inhibitors of NHE-1 Na+/H+ exchange reduce mouse intraocular pressure. | Investigative ophthalmology & visual science 20020601 |
| Intestinal NaCl transport in NHE2 and NHE3 knockout mice. | American journal of physiology. Gastrointestinal and liver physiology 20020501 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| Basolateral membrane Cl(-)-, Na(+)-, and K(+)-coupled base transport mechanisms in rat MTALH. | American journal of physiology. Renal physiology 20020401 |
| Dehydroascorbic acid uptake by coronary artery smooth muscle: effect of intracellular acidification. | The Biochemical journal 20020301 |
| [Modification of damaging effect of ultraviolet radiation on peritoneal macrophage membranes in mice]. | Radiatsionnaia biologiia, radioecologiia 20020101 |
| Ion exchangers mediating NaCl transport in the renal proximal tubule. | Cell biochemistry and biophysics 20020101 |
| Role of NHE isoforms in mediating bicarbonate reabsorption along the nephron. | American journal of physiology. Renal physiology 20011201 |
| Propofol protection of sodium-hydrogen exchange activity sustains glutamate uptake during oxidative stress. | Anesthesia and analgesia 20011101 |
| Inhibition of Na superset+/H superset+ exchange decreases albumin-induced NF-kappaB activation in renal proximal tubular cell lines (OK and LLC-PK1 cells). | European journal of medical research 20011029 |
| Localization and functional characterization of Na+/H+ exchanger isoform NHE4 in rat thick ascending limbs. | American journal of physiology. Renal physiology 20011001 |
| Amiloride derivatives are potent blockers of KATP channels. | Naunyn-Schmiedeberg's archives of pharmacology 20011001 |
| Rapid acid extrusion response triggered by alpha(1) adrenoceptor in CHO cells. | The Journal of physiology 20010815 |
| Inhibition of the Na(+)/H(+) antiporter suppresses IL-12 p40 production by mouse macrophages. | Biochimica et biophysica acta 20010620 |
| Bafilomycin A(1) inhibits rhinovirus infection in human airway epithelium: effects on endosome and ICAM-1. | American journal of physiology. Lung cellular and molecular physiology 20010601 |
| Propofol increases myofilament Ca2+ sensitivity and intracellular pH via activation of Na+-H+ exchange in rat ventricular myocytes. | Anesthesiology 20010601 |
| pH regulation and buffering power in gastric smooth muscle. | Pflugers Archiv : European journal of physiology 20010601 |
| Roles of ATP and cytoskeleton in the regulation of Na+/H+ exchanger along the nephron luminal membrane. | Journal of cellular physiology 20010401 |
| HCO3- salvage mechanisms in the submandibular gland acinar and duct cells. | The Journal of biological chemistry 20010330 |
| Inhibition of Na+-H+ exchanger-3 interferes with apical receptor-mediated endocytosis via vesicle fusion. | The Journal of physiology 20010315 |
| Characterization of apical membrane Cl-dependent Na/H exchange in crypt cells of rat distal colon. | American journal of physiology. Gastrointestinal and liver physiology 20010301 |
| Effects of SM-20550, a selective Na+-H+ exchange inhibitor, on the ion transport of myocardial mitochondria. | Molecular and cellular biochemistry 20010301 |
| Inhibition of the NA(+)/H(+) exchanger reduces rat hepatic stellate cell activity and liver fibrosis: an in vitro and in vivo study. | Gastroenterology 20010201 |
| Protective effect of SM-20550, a selective Na+ - H+ exchange inhibitor, on ischemia-reperfusion-injured hearts. | Journal of cardiovascular pharmacology 20010201 |
| Regulation of tubular cell MCP-1 production by intracellular ions: a role for sodium and calcium. | Experimental nephrology 20010101 |
| The Na(+)/H(+) exchanger SM-20220 attenuates ischemic injury in in vitro and in vivo models. | Pharmacology 20010101 |
| A method for measurement of muscarinic receptor-mediated responses in dissociated single colon longitudinal smooth muscle cells. | Journal of pharmacological and toxicological methods 20010101 |
| Effect of SMP-300, a new Na+/H+ exchange inhibitor, on myocardial ischemia and experimental angina models in rats. | Japanese journal of pharmacology 20001001 |
| Altered inotropic response of endothelin-1 in cardiomyocytes from rats with isoproterenol-induced cardiomyopathy. | Cardiovascular research 19980901 |
| Diamine oxidase is the amiloride-binding protein and is inhibited by amiloride analogues. | The Journal of biological chemistry 19940401 |
| Novel amiloride analog allosterically modulates the alpha 2-adrenergic receptor but does not inhibit Na+/H+ exchange. | Molecular pharmacology 19920801 |
| Human kidney amiloride-binding protein: cDNA structure and functional expression. | Proceedings of the National Academy of Sciences of the United States of America 19901001 |
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