200,000+ products from a single source!

sales@angenechem.com

Home > Bromides > 115338-32-4

115338-32-4

115338-32-4 | 1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-, hydrobromide (1:1)

CAS No: 115338-32-4 Catalog No: AG000GMH MDL No:

Product Description

Catalog Number:
AG000GMH
Chemical Name:
1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-, hydrobromide (1:1)
CAS Number:
115338-32-4
Molecular Formula:
C23H28BrN3O3
Molecular Weight:
474.3907
IUPAC Name:
2-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]isoindole-1,3-dione;hydrobromide
InChI:
InChI=1S/C23H27N3O3.BrH/c1-29-21-11-5-4-10-20(21)25-16-14-24(15-17-25)12-6-7-13-26-22(27)18-8-2-3-9-19(18)23(26)28;/h2-5,8-11H,6-7,12-17H2,1H3;1H
InChI Key:
AXRUEPFPTQYHQD-UHFFFAOYSA-N
SMILES:
COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2.Br

Properties

Complexity:
552  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
473.131g/mol
Formal Charge:
0
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
474.399g/mol
Monoisotopic Mass:
473.131g/mol
Rotatable Bond Count:
7  
Topological Polar Surface Area:
53.1A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0

Literature

Title Journal
Serotonin-induced brain glycogenolysis in rainbow trout (Oncorhynchus mykiss). The Journal of experimental biology 20120901
Involvement of 5-HT1A in the anxiolytic-like effect of dichloromethane fraction of Pimenta pseudocaryophyllus. Journal of ethnopharmacology 20120614
Central pharmacological activity of a new piperazine derivative: 4-(1-phenyl-1h-pyrazol-4-ylmethyl)-piperazine-1-carboxylic acid ethyl ester. Life sciences 20120614
Effects of selective serotonin antagonism on central neurotransmission. Poultry science 20120401
An efficient synthesis of aripiprazole, buspirone and NAN-190 by the reductive alkylation of amines procedure. Archiv der Pharmazie 20120101
[Analysis of 8-OH-DPAT and NAN-190 effects in young prenatally stressed rats under experimental estrogen deficiency conditions]. Eksperimental'naia i klinicheskaia farmakologiia 20120101
5HT(1A) and 5HT(1B) receptors of medial prefrontal cortex modulate anxiogenic-like behaviors in rats. Neuroscience letters 20111031
Involvement of spinal serotonin receptors in electroacupuncture anti-hyperalgesia in an inflammatory pain rat model. Neurochemical research 20111001
Synthesis of 1-naphtylpiperazine derivatives as serotoninergic ligands and their evaluation as antiproliferative agents. European journal of medicinal chemistry 20110601
Serotonin activates MAP kinase and PI3K/Akt signaling pathways in prostate cancer cell lines. Urologic oncology 20110101
Multiple neural oscillators and muscle feedback are required for the intestinal fed state motor program. PloS one 20110101
Effects of 8-OH-DPAT and NAN-190 on anxious-depressive-like behavior of female rats during the estrous cycle. Bulletin of experimental biology and medicine 20101201
8-OH-DPAT prevents morphine-induced apoptosis in rat dorsal raphe nucleus: a possible mechanism for attenuating morphine tolerance. Anesthesia and analgesia 20101101
[Participation of 5-HT2A/2C AND 5-HT2A/2C subtypes of serotonergic receptors in anxiety-depressive-like behaviur of females rats in key phases of ovary cycle]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20100401
Neuronal nitric oxide synthase alteration accounts for the role of 5-HT1A receptor in modulating anxiety-related behaviors. The Journal of neuroscience : the official journal of the Society for Neuroscience 20100217
Serotonergic potentiation of photic phase shifts: examination of receptor contributions and early biochemical/molecular events. Neuroscience 20100113
Methamphetamine reduces LTP and increases baseline synaptic transmission in the CA1 region of mouse hippocampus. PloS one 20100101
[Effect of agonist and antagonist of 5-HT(1A) receptors on learning in female rats during ovarian cycle]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 20100101
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nature chemical biology 20091001
5-HT antagonists NAN-190 and SB 269970 block alpha2-adrenoceptors in the guinea pig. Neuroreport 20090218
Effect of 8-hydroxy-2-(N,N-di-n-propylamino)tetralin and MDMA on the discriminative stimulus effects of the classical hallucinogen DOM in rats. Pharmacology, biochemistry, and behavior 20090101
NAN-190 potentiates the circadian response to light and speeds re-entrainment to advanced light cycles. Neuroscience 20080717
Enhancement of photic shifts with the 5-HT1A mixed agonist/antagonist NAN-190: intra-suprachiasmatic nucleus pathway. Neuroscience 20080515
Serotonergic mediation of aggression in high and low aggressive chicken strains. Poultry science 20080401
Relationship between serotonin and the immune system in a teleost model. Brain, behavior, and immunity 20080201
The involvement of serotonin receptors in suanzaorentang-induced sleep alteration. Journal of biomedical science 20071101
Peripheral 5-HT1A receptors are not essential for increased ventilation evoked by systemic 8-OH-DPAT challenge in anaesthetized rats. Experimental physiology 20070901
NAN-190 potentiates the impairment of retention produced by swim stress. Pharmacology, biochemistry, and behavior 20070501
Screening of 5-HT1A receptor antagonists using molecularly imprinted polymers. Journal of the American Chemical Society 20070214
[Effects of antagonists of 1A and 2A/2C subtypes of serotonin receptors on the depressive behavior and expression of c-Fos protein in hypothalamus of ovariectomized rats]. Eksperimental'naia i klinicheskaia farmakologiia 20070101
Potentiation of the resetting effects of light on circadian rhythms of hamsters using serotonin and neuropeptide Y receptor antagonists. Neuroscience 20060901
Characteristics of binding of [3H]WAY100635 to rat hippocampal membranes. Neurochemical research 20060901
Conformational restriction in novel NAN-190 and MP3022 analogs and their 5-HT(1A) receptor activity. Archiv der Pharmazie 20060901
Combined administration of NAN-190 and 17beta-estradiol abolishes the amnesic effect of scopolamine in middle-aged ovariectomized rats. Bulletin of experimental biology and medicine 20060701
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Investigation of mechanisms mediating 8-OH-DPAT-induced impairment of spatial memory: involvement of 5-HT1A receptors in the dorsal hippocampus in rats. Brain research 20060119
[Effect of 8-OH-DPAT on the depressive behavior and monoamine metabolism in the hippocampus of ovariectomized rats]. Eksperimental'naia i klinicheskaia farmakologiia 20060101
Doxazosin and serotonin (5-HT) receptor (1A, 2A, and 4) antagonists inhibit 5-HT-mediated human cavernosal contraction. Journal of andrology 20060101
[Optimizing effect of the combined administration of 8-OH-DPAT and galantamine on depression--anxiety behavior in old rats with dementia of Alzheimer's type]. Eksperimental'naia i klinicheskaia farmakologiia 20060101
The role of serotonin in tumour growth (review). Oncology reports 20051201
Antinociceptive effect of shakuyakukanzoto, a Kampo medicine, in diabetic mice. Journal of pharmacological sciences 20051201
Noradrenergic agonists and antagonists influence migration of cortical spreading depression in rat-a possible mechanism of migraine prophylaxis and prevention of postischemic neuronal damage. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20050901
Voltage-dependent calcium currents in trigeminal motoneurons of early postnatal rats: modulation by 5-HT receptors. Journal of neurophysiology 20050901
Postnatal treatment with NAN-190 but not with 5-HT1A receptor agonists retards growth of the rat brain. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20050801
In vitro profile of the antidepressant candidate OPC-14523 at rat and human 5-HT1A receptors. European journal of pharmacology 20050711
NAN-190, a possible specific antagonist for methamphetamine. Regulatory toxicology and pharmacology : RTP 20050301
Dynamics of fast synaptic excitation during trains of stimulation in myenteric neurons of guinea-pig ileum. Autonomic neuroscience : basic & clinical 20050207
Acute effect of milnacipran on the relationship between the locus coeruleus noradrenergic and dorsal raphe serotonergic neuronal transmitters. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20041201
An antagonistic 5-HT receptor system in the auricles of the systemic heart complex of Sepia officinalis L. (Cephalopoda) shows 5-HT1 and 5-HT4 subtype properties. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20040601
Serotonergic regulation of the central heart auricles of Sepia officinalis L. (Mollusca, Cephalopoda). Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20040501
New imide 5-HT1A receptor ligands - modification of terminal fragment geometry. Molecules (Basel, Switzerland) 20040227
Neurokinin-1 and -3 receptor blockade inhibits slow excitatory synaptic transmission in myenteric neurons and reveals slow inhibitory input. Neuroscience 20040101
Effects of 5-HT1A receptor agonist and antagonist on anxiety in intact and ovariectomized female rats. Acta physiologica Hungarica 20040101
Involvement of 5-HT1A receptors in passive avoidance learning in intact and ovariectomized female rats. Acta physiologica Hungarica 20040101
Enhanced retention in the passive-avoidance task by 5-HT(1A) receptor blockade is not associated with increased activity of the central nucleus of the amygdala. Learning & memory (Cold Spring Harbor, N.Y.) 20030901
Is serotonin significant for the control of penile flaccidity and detumescence in the human male? Urological research 20030601
5-HT(7)-like receptors mediate serotonergic modulation of photo-responsiveness of the medulla bilateral neurons in the cricket, Gryllus bimaculatus. Zoological science 20030301
Fluvoxamine suppresses the long-term potentiation in the hippocampal CA1 field of anesthetized rats: an effect mediated via 5-HT1A receptors. Brain research 20030103
Effects of cholecystokinin tetrapeptide (CCK(4)) and of anxiolytic drugs on GABA outflow from the cerebral cortex of freely moving rats. Neurochemistry international 20030101
Evidence that acute serotonergic activation potentiates the locomotor-stimulating effects of corticotropin-releasing hormone in juvenile chinook salmon (Oncorhynchus tshawytscha). Hormones and behavior 20030101
Evidence that NAN-190-induced hypotension involves vascular alpha1-adrenoceptor antagonism in the rat. European journal of pharmacology 20021122
Effect of serotonin (5-HT) on trigeminal rhythmic activities generated in in vitro brainstem block preparations. Journal of dental research 20020901
Central antinociceptive activity of acetylsalicylic acid is modulated by brain serotonin receptor subtypes. Pharmacology 20020801
[Effect of (+/-)-pindolol on the central 5-HT1A receptor by the use of in vivo microdialysis and hippocampal slice preparations]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20020601
Hyperpolarization-activated current I(h) in nucleus of solitary tract neurons: regional difference in serotonergic modulation. Japanese journal of pharmacology 20020401
Pharmacological analysis of the hypothermic effects of NAN-190 and its analogs, postsynaptic 5-HT1A receptor antagonists, in mice. Polish journal of pharmacology 20020101
Modulation of voltage-dependent calcium currents by serotonin in acutely isolated rat amygdala neurons. Synapse (New York, N.Y.) 20010915
Involvement of the serotonergic type 1A (5-HT1A) receptor in the agranular insular cortex in the consolidation of memory for inhibitory avoidance in rats. Behavioural pharmacology 20010901
5-Hydroxytryptamine facilitates spatiotemporal propagation of optical signals in the hippocampal-septal pathway. Neuroscience research 20010701
Rostral ventral medulla 5-HT1A receptors selectively inhibit the somatosympathetic reflex. American journal of physiology. Regulatory, integrative and comparative physiology 20010501
Influence of serotonin receptor antagonists on substance P and serotonin release evoked by tooth pulp stimulation with electro-acupuncture in the trigeminal nucleus cudalis of the rabbit. Neuroscience research 20010501
The role of 5-hydroxytryptamine1A and 5-hydroxytryptamine1B receptors in modulating spinal nociceptive transmission in normal and carrageenan-injected rats. Pain 20010501
Differential effect of serotonin 5-HT(1A) receptor antagonists on the secretion of corticotropin and prolactin. Neuroendocrinology 20010501
Heuristic statistical analysis of fluorescence fluctuation data with bright spikes: application to ligand binding to the human serotonin receptor expressed in Escherichia coli cells. Biological chemistry 20010301
Binding affinity of sarpogrelate, a new antiplatelet agent, and its metabolite for serotonin receptor subtypes. Archives internationales de pharmacodynamie et de therapie 19960101

Related Products

© 2019 Angene International Limited. All rights Reserved.