200,000+ products from a single source!
sales@angenechem.com
115256-11-6 | Methanesulfonamide, N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]-
CAS No: 115256-11-6 Catalog No: AG000GJ8 MDL No:MFCD00869707
Product Description
Catalog Number:
AG000GJ8
Chemical Name:
Methanesulfonamide, N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]-
CAS Number:
115256-11-6
Molecular Formula:
C19H27N3O5S2
Molecular Weight:
441.5648
MDL Number:
MFCD00869707
IUPAC Name:
N-[4-[2-[2-[4-(methanesulfonamido)phenoxy]ethyl-methylamino]ethyl]phenyl]methanesulfonamide
InChI:
InChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3
InChI Key:
IXTMWRCNAAVVAI-UHFFFAOYSA-N
SMILES:
CN(CCc1ccc(cc1)NS(=O)(=O)C)CCOc1ccc(cc1)NS(=O)(=O)C
UNII:
R4Z9X1N2ND
Properties
Complexity:
672
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
441.139g/mol
Formal Charge:
0
Heavy Atom Count:
29
Hydrogen Bond Acceptor Count:
8
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
441.561g/mol
Monoisotopic Mass:
441.139g/mol
Rotatable Bond Count:
11
Topological Polar Surface Area:
122A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.8
Literature
| Title | Journal |
|---|---|
| Long-term channel block is required to inhibit cellular transformation by human ether-à-go-go-related gene (hERG1) potassium channels. | Molecular pharmacology 20140801 |
| Allosteric modulators of the hERG K(+) channel: radioligand binding assays reveal allosteric characteristics of dofetilide analogs. | Toxicology and applied pharmacology 20140101 |
| Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model. | Toxicological sciences : an official journal of the Society of Toxicology 20131201 |
| The effect on rat embryonic heart rate of Na+, K+, and Ca2+ channel blockers, and the human teratogen phenytoin, changes with gestational age. | Birth defects research. Part B, Developmental and reproductive toxicology 20131001 |
| Identification and characterization of a compound that protects cardiac tissue from human Ether-à-go-go-related gene (hERG)-related drug-induced arrhythmias. | The Journal of biological chemistry 20121116 |
| Antipsychotic drugs cause bradycardia in GD 13 rat embryos in vitro. | Reproductive toxicology (Elmsford, N.Y.) 20121101 |
| Relevance of calmodulin/CaMKII activation for arrhythmogenesis in the AV block dog. | Heart rhythm 20121101 |
| Impact of Na⁺ channel blockers on transmural dispersion of refractoriness and arrhythmic susceptibility in guinea-pig left ventricle. | European journal of pharmacology 20120915 |
| Negative electro-mechanical windows are required for drug-induced Torsades de Pointes in the anesthetized guinea pig. | Journal of pharmacological and toxicological methods 20120901 |
| The role of the anaesthetised guinea-pig in the preclinical cardiac safety evaluation of drug candidate compounds. | Toxicology and applied pharmacology 20120901 |
| Frequency-dependent acceleration of cardiac repolarization by progesterone underlying its cardiac protection against drug-induced proarrhythmic effects in female rabbits. | European journal of pharmacology 20120815 |
| Comparison of the effects of DC031050, a class III antiarrhythmic agent, on hERG channel and three neuronal potassium channels. | Acta pharmacologica Sinica 20120601 |
| Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. | Journal of medicinal chemistry 20120524 |
| Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation. | The Cochrane database of systematic reviews 20120516 |
| Field and action potential recordings in heart slices: correlation with established in vitro and in vivo models. | British journal of pharmacology 20120501 |
| The electro-mechanical window in anaesthetized guinea pigs: a new marker in screening for Torsade de Pointes risk. | British journal of pharmacology 20120501 |
| Characterization of A-935142, a hERG enhancer, in the presence and absence of standard hERG blockers. | Life sciences 20120420 |
| Structure-activity relationships, ligand efficiency, and lipophilic efficiency profiles of benzophenone-type inhibitors of the multidrug transporter P-glycoprotein. | Journal of medicinal chemistry 20120412 |
| An in silico canine cardiac midmyocardial action potential duration model as a tool for early drug safety assessment. | American journal of physiology. Heart and circulatory physiology 20120401 |
| Effects of a novel amiodarone-like compound SAR114646A on the pig atrium and susceptibility to ventricular fibrillation in dogs and pigs. | Naunyn-Schmiedeberg's archives of pharmacology 20120401 |
| Ventricular remodelling is a prerequisite for the induction of dofetilide-induced torsade de pointes arrhythmias in the anaesthetized, complete atrio-ventricular-block dog. | Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20120301 |
| Dofetilide reduces the frequency of ventricular arrhythmias and implantable cardioverter defibrillator therapies. | Journal of cardiovascular electrophysiology 20120301 |
| Metabolic syndrome potentiates the cardiac action potential-prolonging action of drugs: a possible 'anti-proarrhythmic' role for amlodipine. | Pharmacological research 20120301 |
| Coronary artery disease potentiates response to dofetilide for rhythm control of atrial fibrillation. | Pacing and clinical electrophysiology : PACE 20120201 |
| Reduced ventricular proarrhythmic potential of the novel combined ion-channel blocker AZD1305 versus dofetilide in dogs with remodeled hearts. | Circulation. Arrhythmia and electrophysiology 20120201 |
| Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes. | British journal of pharmacology 20120101 |
| Managing atrial fibrillation in the elderly: critical appraisal of dronedarone. | Clinical interventions in aging 20120101 |
| IKs protects from ventricular arrhythmia during cardiac ischemia and reperfusion in rabbits by preserving the repolarization reserve. | PloS one 20120101 |
| Cost considerations in the management of atrial fibrillation - impact of dronedarone. | ClinicoEconomics and outcomes research : CEOR 20120101 |
| Survey of methadone-drug interactions among patients of methadone maintenance treatment program in Taiwan. | Substance abuse treatment, prevention, and policy 20120101 |
| Costs and clinical consequences of suboptimal atrial fibrillation management. | ClinicoEconomics and outcomes research : CEOR 20120101 |
| Omega-3 Fatty acids: anti-arrhythmic, pro-arrhythmic, or both? | Frontiers in physiology 20120101 |
| Sudden death of cardiac origin and psychotropic drugs. | Frontiers in pharmacology 20120101 |
| Mechanisms, risk factors, and management of acquired long QT syndrome: a comprehensive review. | TheScientificWorldJournal 20120101 |
| Assessment of QT-prolonging drugs in the isolated normal and failing rabbit hearts. | The Journal of toxicological sciences 20120101 |
| Effects of K201 on repolarization and arrhythmogenesis in anesthetized chronic atrioventricular block dogs susceptible to dofetilide-induced torsade de pointes. | European journal of pharmacology 20111215 |
| Interaction of specialized cardiac conduction system with antiarrhythmic drugs: a simulation study. | IEEE transactions on bio-medical engineering 20111201 |
| Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). | PLoS computational biology 20111201 |
| A mechanism underlying compound-induced voltage shift in the current activation of hERG by antiarrhythmic agents. | Biochemical and biophysical research communications 20111111 |
| Pharmacological inhibition of the hERG potassium channel is modulated by extracellular but not intracellular acidosis. | Journal of cardiovascular electrophysiology 20111001 |
| Evaluation of syncope and palpitations in women. | Journal of women's health (2002) 20111001 |
| Analysis of the contribution of I(to) to repolarization in canine ventricular myocardium. | British journal of pharmacology 20110901 |
| hERG subunit composition determines differential drug sensitivity. | British journal of pharmacology 20110901 |
| Managing patients with ICD shocks and programming tachycardia therapies during acute heart failure syndromes. | Heart failure reviews 20110901 |
| Estimating the risk of drug-induced proarrhythmia using human induced pluripotent stem cell-derived cardiomyocytes. | Toxicological sciences : an official journal of the Society of Toxicology 20110901 |
| A personalized medicine target: heart failure in women. | Journal of medicine and life 20110815 |
| Functional characterization of the LQT2-causing mutation R582C and the associated voltage-dependent fluorescence signal. | Heart rhythm 20110801 |
| The acute inotropic effects of cardiac contractility modulation (CCM) are associated with action potential duration shortening and mediated by β1-adrenoceptor signalling. | Journal of molecular and cellular cardiology 20110801 |
| Impact of dronedarone on hospitalization burden in patients with atrial fibrillation: results from the ATHENA study. | Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20110801 |
| Identification of a novel bacterial K(+) channel. | The Journal of membrane biology 20110801 |
| Is antiarrhythmic treatment in the elderly different? a review of the specific changes. | Drugs & aging 20110801 |
| Novel roles for hERG K(+) channels in cell proliferation and apoptosis. | Cell death & disease 20110801 |
| Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile. | Journal of medicinal chemistry 20110714 |
| Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk. | Cardiovascular research 20110701 |
| Dofetilide dose calculation errors in elderly associated with use of the modification of diet in renal disease equation. | The Annals of pharmacotherapy 20110701 |
| I(Kr) vs. I(Ks) blockade and arrhythmogenicity in normoxic rabbit Purkinje fibers: does it really make a difference? | Fundamental & clinical pharmacology 20110601 |
| The duration of pacing-induced atrial fibrillation is reduced in vivo by inhibition of small conductance Ca(2+)-activated K(+) channels. | Journal of cardiovascular pharmacology 20110601 |
| Lengthening of cardiac repolarization in isolated guinea pigs hearts by sequential or concomitant administration of two IKr blockers. | Journal of pharmaceutical sciences 20110601 |
| Mild Pd-catalyzed N-arylation of methanesulfonamide and related nucleophiles: avoiding potentially genotoxic reagents and byproducts. | Organic letters 20110520 |
| Contribution of late sodium current (I(Na-L)) to rate adaptation of ventricular repolarization and reverse use-dependence of QT-prolonging agents. | Heart rhythm 20110501 |
| Simulation of the undiseased human cardiac ventricular action potential: model formulation and experimental validation. | PLoS computational biology 20110501 |
| BeKm-1, a peptide inhibitor of human ether-a-go-go-related gene potassium currents, prolongs QTc intervals in isolated rabbit heart. | The Journal of pharmacology and experimental therapeutics 20110401 |
| Design and synthesis of novel CCR2 antagonists: investigation of non-aryl/heteroaryl binding motifs. | Bioorganic & medicinal chemistry letters 20110315 |
| Regional genomic regulation of cardiac sodium-calcium exchanger by oestrogen. | The Journal of physiology 20110301 |
| Pulmonary vein isolation alone in patients with persistent atrial fibrillation: an ablation strategy facilitated by antiarrhythmic drug induced reverse remodeling. | Journal of cardiovascular electrophysiology 20110201 |
| Aminopyridinecarboxamide-based inhaled IKK-2 inhibitors for asthma and COPD: Structure-activity relationship. | Bioorganic & medicinal chemistry 20110201 |
| Efficacy and safety of dofetilide in the treatment of frequent ventricular tachyarrhythmias after amiodarone intolerance or failure. | Journal of the American College of Cardiology 20110118 |
| Beat-by-beat QT interval variability, but not QT prolongation per se, predicts drug-induced torsades de pointes in the anaesthetised methoxamine-sensitized rabbit. | Journal of pharmacological and toxicological methods 20110101 |
| Effects of the antiarrhythmic drug dofetilide on transmural dispersion of repolarization in ventriculum. A computer modeling study. | IEEE transactions on bio-medical engineering 20110101 |
| Ionic mechanisms of pacemaker activity in spontaneously contracting atrial HL-1 cells. | Journal of cardiovascular pharmacology 20110101 |
| A KCR1 variant implicated in susceptibility to the long QT syndrome. | Journal of molecular and cellular cardiology 20110101 |
| Characterization of cardiac repolarization in the Göttingen minipig. | Journal of pharmacological and toxicological methods 20110101 |
| Electrophysiological properties of HBI-3000: a new antiarrhythmic agent with multiple-channel blocking properties in human ventricular myocytes. | Journal of cardiovascular pharmacology 20110101 |
| Electrophysiology and adult congenital heart disease: advances and options. | Progress in cardiovascular diseases 20110101 |
| Treatment of atrial fibrillation with a dual defibrillator in heart failure patients (TRADE HF): protocol for a randomized clinical trial. | Trials 20110101 |
| Pharmacokinetic-pharmacodynamic modelling of the effect of Moxifloxacin on QTc prolongation in telemetered cynomolgus monkeys. | Journal of pharmacological and toxicological methods 20110101 |
| Atrial fibrillation and the use of oral bisphosphonates. | Therapeutics and clinical risk management 20110101 |
| Atomistic models for free energy evaluation of drug binding to membrane proteins. | Current medicinal chemistry 20110101 |
| Incidence of atrial fibrillation in patients with either heart failure or acute myocardial infarction and left ventricular dysfunction: a cohort study. | BMC cardiovascular disorders 20110101 |
| Pharmacological management of atrial fibrillation: one, none, one hundred thousand. | Cardiology research and practice 20110101 |
| Vascular endothelial growth factor inhibitor-induced hypertension: basics for primary care providers. | Cardiology research and practice 20110101 |
| Powerful technique to test selectivity of agents acting on cardiac ion channels: the action potential voltage-clamp. | Current medicinal chemistry 20110101 |
| Management of patients with atrial fibrillation: specific considerations for the old age. | Cardiology research and practice 20110101 |
| Inhibition of HERG potassium channels by celecoxib and its mechanism. | PloS one 20110101 |
| Safety and efficacy of dronedarone in the treatment of atrial fibrillation/flutter. | Clinical Medicine Insights. Cardiology 20110101 |
| In silico analysis of conformational changes induced by mutation of aromatic binding residues: consequences for drug binding in the hERG K+ channel. | PloS one 20110101 |
| Biomarkers and endogenous determinants of dofetilide-induced torsades de pointes in α(1) -adrenoceptor-stimulated, anaesthetized rabbits. | British journal of pharmacology 20101201 |
| Identification of human Ether-à-go-go related gene modulators by three screening platforms in an academic drug-discovery setting. | Assay and drug development technologies 20101201 |
| Successful drug development despite adverse preclinical findings part 1: processes to address issues and most important findings. | Journal of toxicologic pathology 20101201 |
| Calcium oscillations and T-wave lability precede ventricular arrhythmias in acquired long QT type 2. | Heart rhythm 20101101 |
| Oscillations of cardiac wave length and proarrhythmia. | Naunyn-Schmiedeberg's archives of pharmacology 20101001 |
| Electrophysiological studies of transgenic long QT type 1 and type 2 rabbits reveal genotype-specific differences in ventricular refractoriness and His conduction. | American journal of physiology. Heart and circulatory physiology 20100901 |
| Worsening heart failure in the setting of dronedarone initiation. | The Annals of pharmacotherapy 20100901 |
| Robust anti-arrhythmic efficacy of verapamil and flunarizine against dofetilide-induced TdP arrhythmias is based upon a shared and a different mode of action. | British journal of pharmacology 20100901 |
| Dronedarone in patients with congestive heart failure: insights from ATHENA. | European heart journal 20100701 |
| Pharmacologic prophylaxis of postoperative atrial fibrillation in patients undergoing cardiac surgery: beyond beta-blockers. | Pharmacotherapy 20100701 |
| Effects of sarcolemmal Ca(2+) entry, ryanodine function, and kinase inhibitors on a rabbit model of heart failure. | International heart journal 20100701 |
| Arrhythmic risk biomarkers for the assessment of drug cardiotoxicity: from experiments to computer simulations. | Philosophical transactions. Series A, Mathematical, physical, and engineering sciences 20100628 |
| The prognostic impact of shocks for clinical and induced arrhythmias on morbidity and mortality among patients with implantable cardioverter-defibrillators. | Heart rhythm 20100601 |
| Substrate and Trigger Ablation for Reduction of Atrial Fibrillation (STAR AF): a randomized, multicentre, international trial. | European heart journal 20100601 |
| Characterization of the rapidly activating delayed rectifier potassium current, I (Kr), in HL-1 mouse atrial myocytes. | The Journal of membrane biology 20100601 |
| Anesthesia and arrhythmogenesis in the chronic atrioventricular block dog model. | Journal of cardiovascular pharmacology 20100601 |
| Gender in atrial fibrillation: Ten years later. | Gender medicine 20100601 |
| Reverse rate-dependent changes are determined by baseline action potential duration in mammalian and human ventricular preparations. | Basic research in cardiology 20100501 |
| Long-term prognostic importance of resting heart rate in patients with left ventricular dysfunction in connection with either heart failure or myocardial infarction: the DIAMOND study. | International journal of cardiology 20100430 |
| Altered cytosolic Ca2+ dynamics in cultured Guinea pig cardiomyocytes as an in vitro model to identify potential cardiotoxicants. | Toxicology in vitro : an international journal published in association with BIBRA 20100401 |
| Interactions at human ether-à-go-go-related gene channels. | Toxicological sciences : an official journal of the Society of Toxicology 20100401 |
| Inhibition of IK,ACh current may contribute to clinical efficacy of class I and class III antiarrhythmic drugs in patients with atrial fibrillation. | Naunyn-Schmiedeberg's archives of pharmacology 20100301 |
| Late na(+) current inhibition by ranolazine reduces torsades de pointes in the chronic atrioventricular block dog model. | Journal of the American College of Cardiology 20100223 |
| Dog left ventricular midmyocardial myocytes for assessment of drug-induced delayed repolarization: short-term variability and proarrhythmic potential. | British journal of pharmacology 20100101 |
| I(Ks) restricts excessive beat-to-beat variability of repolarization during beta-adrenergic receptor stimulation. | Journal of molecular and cellular cardiology 20100101 |
| High defibrillation threshold: the science, signs and solutions. | Indian pacing and electrophysiology journal 20100101 |
| The isolated rabbit heart and Purkinje fibers as models for identifying proarrhythmic liability. | Journal of pharmacological and toxicological methods 20100101 |
| Acute effects of sex steroid hormones on susceptibility to cardiac arrhythmias: a simulation study. | PLoS computational biology 20100101 |
| Daurisoline suppressed early afterdepolarizations and inhibited L-type calcium current. | The American journal of Chinese medicine 20100101 |
| Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 degrees C: Cisapride versus dofetilide. | Journal of pharmacological and toxicological methods 20100101 |
| New atypical antipsychotics for schizophrenia: iloperidone. | Drug design, development and therapy 20100101 |
| Long-term fish oil supplementation induces cardiac electrical remodeling by changing channel protein expression in the rabbit model. | PloS one 20100101 |
| Resolving anaphoras for the extraction of drug-drug interactions in pharmacological documents. | BMC bioinformatics 20100101 |
| Uni- or bi-ventricular hypertrophy and susceptibility to drug-induced torsades de pointes. | Journal of pharmacological and toxicological methods 20100101 |
| Fluorescence-tracking of activation gating in human ERG channels reveals rapid S4 movement and slow pore opening. | PloS one 20100101 |
| CPU228, a derivative of dofetilide, relieves cardiac dysfunction by normalizing FKBP12.6, NADPH oxidase and protein kinase C epsilon in the myocardium. | The Journal of pharmacy and pharmacology 20100101 |
| Amiodarone for the treatment and prevention of ventricular fibrillation and ventricular tachycardia. | Vascular health and risk management 20100101 |
| Dronedarone for the treatment of atrial fibrillation and atrial flutter: approval and efficacy. | Vascular health and risk management 20100101 |
| Selective inhibitors of Kv11.1 regulate IL-6 expression by macrophages in response to TLR/IL-1R ligands. | TheScientificWorldJournal 20100101 |
| Premature Ventricular Contractions and Non-sustained Ventricular Tachycardia: Association with Sudden Cardiac Death, Risk Stratification, and Management Strategies. | Indian pacing and electrophysiology journal 20100101 |
| Recent advances in the management of chronic stable angina II. Anti-ischemic therapy, options for refractory angina, risk factor reduction, and revascularization. | Vascular health and risk management 20100101 |
| Sex and age related differences in drug induced QT prolongation by dofetilide under reduced repolarization reserve in simulated ventricular cells. | Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 20100101 |
| Anaemia and long term mortality in heart failure patients: a retrospective study. | The open cardiovascular medicine journal 20100101 |
| Eag and HERG potassium channels as novel therapeutic targets in cancer. | World journal of surgical oncology 20100101 |
| Clinical safety and tolerability issues in use of triazole derivatives in management of fungal infections. | Drug, healthcare and patient safety 20100101 |
| Stereoselective Inhibition of the hERG1 Potassium Channel. | Frontiers in pharmacology 20100101 |
| Reverse rate dependency is an intrinsic property of canine cardiac preparations. | Cardiovascular research 20091101 |
| Dofetilide is safe and effective in preventing atrial fibrillation recurrences in patients accepted for catheter ablation. | Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20091101 |
| Inhibitory effects of dauricine on early afterdepolarizations and L-type calcium current. | Canadian journal of physiology and pharmacology 20091101 |
| Dronedarone: a promising alternative for the management of atrial fibrillation. | Cardiovascular drugs and therapy 20091001 |
| Dofetilide for atrial arrhythmias in congenital heart disease: a multicenter study. | Pacing and clinical electrophysiology : PACE 20091001 |
| Exploring chemical substructures essential for HERG k(+) channel blockade by synthesis and biological evaluation of dofetilide analogues. | ChemMedChem 20091001 |
| [Effects of combined use of dofetilide and verapamil on the action potential of papillary muscles in guinea pigs]. | Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20090901 |
| Impact of glucose concentration on cardiac ventricular repolarization under I Kr/I Ks blocking agents. | Journal of molecular and cellular cardiology 20090801 |
| Treatment of atrial fibrillation with antiarrhythmic drugs or radiofrequency ablation: two systematic literature reviews and meta-analyses. | Circulation. Arrhythmia and electrophysiology 20090801 |
| Recent advances in pharmacotherapy of atrial fibrillation. | Indian journal of pharmacology 20090801 |
| Iatrogenic QT Abnormalities and Fatal Arrhythmias: Mechanisms and Clinical Significance. | Current cardiology reviews 20090801 |
| Intravenous magnesium sulfate enhances the ability of dofetilide to successfully cardiovert atrial fibrillation or flutter: results of the Dofetilide and Intravenous Magnesium Evaluation. | Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20090701 |
| Identification of Ikr kinetics and drug binding in native myocytes. | Annals of biomedical engineering 20090701 |
| Effects of potassium channel blockers on changes in refractoriness of atrial cardiomyocytes induced by stretch. | Experimental biology and medicine (Maywood, N.J.) 20090701 |
| Assessment of the ion channel-blocking profile of the novel combined ion channel blocker AZD1305 and its proarrhythmic potential versus dofetilide in the methoxamine-sensitized rabbit in vivo. | Journal of cardiovascular pharmacology 20090701 |
| Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity. | Bioorganic & medicinal chemistry letters 20090615 |
| Dofetilide enhances the contractility of rat ventricular myocytes via augmentation of Na+-Ca 2+ exchange. | Cardiovascular drugs and therapy 20090601 |
| Dofetilide as activator of Na/Ca exchange: new perspectives on an 'old' drug. Editorial to: 'Dofetilide enhances the contractility of rat ventricular myocytes via augmentation of Na+-Ca 2+ exchange' by Xuan-Ping Zhang et al. | Cardiovascular drugs and therapy 20090601 |
| The evolutionarily conserved residue A653 plays a key role in HERG channel closing. | The Journal of physiology 20090601 |
| Initial experience with antiarrhythmic medication monitoring by clinical pharmacists in an outpatient setting: a retrospective review. | Clinical therapeutics 20090601 |
| Loss of functional K+ channels encoded by ether-à-go-go-related genes in mouse myometrium prior to labour onset. | The Journal of physiology 20090515 |
| Analogs of MK-499 are differentially affected by a mutation in the S6 domain of the hERG K+ channel. | Biochemical pharmacology 20090515 |
| Cost of hospital admission for antiarrhythmic drug initiation in atrial fibrillation. | The Annals of pharmacotherapy 20090501 |
| A preliminary assessment of the effects of ATI-2042 in subjects with paroxysmal atrial fibrillation using implanted pacemaker methodology. | Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20090401 |
| Alternatives to amiodarone: search for the Holy Grail. | Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20090401 |
| Safety of the novel atrial-selective K+-channel blocker AVE0118 in experimental heart failure. | Naunyn-Schmiedeberg's archives of pharmacology 20090301 |
| The role of the Na+/Ca2+ exchanger, I(Na) and I(CaL) in the genesis of dofetilide-induced torsades de pointes in isolated, AV-blocked rabbit hearts. | British journal of pharmacology 20090301 |
| Gender-related differences in drug-induced prolongation of cardiac repolarization in prepubertal guinea pigs. | Journal of cardiovascular pharmacology and therapeutics 20090301 |
| Regulation of antiarrhythmic drug propafenone effects on the c-type Kv1.4 potassium channel by PHo and K+. | Journal of Korean medical science 20090201 |
| Calculation of QT shift in non clinical safety pharmacology studies. | Journal of pharmacological and toxicological methods 20090101 |
| The effect of dofetilide on ventricular defibrillation thresholds. | Pacing and clinical electrophysiology : PACE 20090101 |
| Validation of a voltage-sensitive dye (di-4-ANEPPS)-based method for assessing drug-induced delayed repolarisation in beagle dog left ventricular midmyocardial myocytes. | Journal of pharmacological and toxicological methods 20090101 |
| Effect of compound plate composition on measurement of hERG current IC(50) using PatchXpress. | Journal of pharmacological and toxicological methods 20090101 |
| Electrical cardioversion. | Annals of Saudi medicine 20090101 |
| Models of torsades de pointes: effects of FPL64176, DPI201106, dofetilide, and chromanol 293B in isolated rabbit and guinea pig hearts. | Journal of pharmacological and toxicological methods 20090101 |
| Dronedarone for atrial fibrillation: a new therapeutic agent. | Vascular health and risk management 20090101 |
| The use of oral ranolazine to convert new or paroxysmal atrial fibrillation: a review of experience with implications for possible 'pill in the pocket' approach to atrial fibrillation. | Indian pacing and electrophysiology journal 20090101 |
| Drugs associated with more suicidal ideations are also associated with more suicide attempts. | PloS one 20090101 |
| Cardiac arrhythmias in congenital heart diseases. | Indian pacing and electrophysiology journal 20090101 |
| Advances in the management of atrial fibrillation in congestive heart failure. | F1000 medicine reports 20090101 |
| An in vitro model for assessment of drug-induced torsade de pointes arrhythmia : effects of haloperidol and dofetilide on potential duration, repolarization inhomogeneities, and torsade de pointes arrhythmia. | Naunyn-Schmiedeberg's archives of pharmacology 20081201 |
| Slow delayed rectifier K+ current block by HMR 1556 increases dispersion of repolarization and promotes Torsades de Pointes in rabbit ventricles. | British journal of pharmacology 20081201 |
| Prognostic importance of change in QRS duration over time associated with left ventricular dysfunction in patients with congestive heart failure: the DIAMOND study. | Journal of cardiac failure 20081201 |
| Efficacy and safety of dofetilide in patients with atrial fibrillation and atrial flutter. | Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 20081101 |
| Drug binding to the inactivated state is necessary but not sufficient for high-affinity binding to human ether-à-go-go-related gene channels. | Molecular pharmacology 20081101 |
| Ultrafast sodium channel block by dietary fish oil prevents dofetilide-induced ventricular arrhythmias in rabbit hearts. | American journal of physiology. Heart and circulatory physiology 20081001 |
| The use of clinical irrelevance criteria in covariate model building with application to dofetilide pharmacokinetic data. | Journal of pharmacokinetics and pharmacodynamics 20081001 |
| Feedback remodeling of cardiac potassium current expression: a novel potential mechanism for control of repolarization reserve. | Circulation 20080902 |
| Repolarization reserve: a moving target. | Circulation 20080902 |
| In silico risk assessment for drug-induction of cardiac arrhythmia. | Progress in biophysics and molecular biology 20080901 |
| Dofetilide for the prevention of postoperative atrial fibrillation after coronary surgery: is it a useful routine prophylaxis? | The American journal of cardiology 20080815 |
| Predicting drug-induced changes in QT interval and arrhythmias: QT-shortening drugs point to gaps in the ICHS7B Guidelines. | British journal of pharmacology 20080801 |
| The cardiovascular and pharmacokinetic profile of dofetilide in conscious telemetered beagle dogs and cynomolgus monkeys. | British journal of pharmacology 20080801 |
| Safety considerations in the pharmacological management of atrial fibrillation. | International journal of cardiology 20080721 |
| Late dofetilide-associated life-threatening proarrhythmia. | International journal of cardiology 20080704 |
| Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndrome. | Cardiovascular research 20080701 |
| Probing the binding sites and mechanisms of action of two human ether-a-go-go-related gene channel activators, 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243). | Molecular pharmacology 20080601 |
| Usefulness of dofetilide for the prevention of atrial tachyarrhythmias (atrial fibrillation or flutter) after coronary artery bypass grafting. | The American journal of cardiology 20080601 |
| Multiple episodes of ventricular tachycardia induced by silent coronary vasospasm. | Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 20080401 |
| Erg K+ channels modulate contractile activity in the bovine epididymal duct. | American journal of physiology. Regulatory, integrative and comparative physiology 20080301 |
| Spatial heterogeneity of myocardial perfusion predicts local potassium channel expression and action potential duration. | Cardiovascular research 20080201 |
| Characterization of in vivo and in vitro electrophysiological and antiarrhythmic effects of a novel IKACh blocker, NIP-151: a comparison with an IKr-blocker dofetilide. | Journal of cardiovascular pharmacology 20080201 |
| Relevance of anaesthesia for dofetilide-induced torsades de pointes in alpha1-adrenoceptor-stimulated rabbits. | British journal of pharmacology 20080101 |
| The additive effects of the active component of grapefruit juice (naringenin) and antiarrhythmic drugs on HERG inhibition. | Cardiology 20080101 |
| Effect of drugs on defibrillation capacity. | Drugs 20080101 |
| The role of antiarrhythmic drug therapy for the prevention of sudden cardiac death. | Progress in cardiovascular diseases 20080101 |
| Relationship among amiodarone, new class III antiarrhythmics, miscellaneous agents and acquired long QT syndrome. | Cardiology journal 20080101 |
| The effect of ranolazine on maintaining sinus rhythm in patients with resistant atrial fibrillation. | Indian pacing and electrophysiology journal 20080101 |
| Is cardiac resynchronisation therapy proarrhythmic? | Indian pacing and electrophysiology journal 20080101 |
| Effect of atrial electrical remodeling on the efficacy of antiarrhythmic drugs: comparison of amiodarone with I(Kr)- and I(to)/IKur-blockade in vivo. | Journal of cardiovascular electrophysiology 20071201 |
| Amiodarone and atrial fibrillation. | Journal of cardiovascular electrophysiology 20071201 |
| Acute conversion of persistent atrial fibrillation during dofetilide initiation. | Pacing and clinical electrophysiology : PACE 20071201 |
| Optical measurements of intramural action potentials in isolated porcine hearts using optrodes. | Heart rhythm 20071101 |
| Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation. | The Cochrane database of systematic reviews 20071017 |
| Discovery of novel and orally active NR2B-selective N-methyl-D-aspartate (NMDA) antagonists, pyridinol derivatives with reduced HERG binding affinity. | Bioorganic & medicinal chemistry letters 20071015 |
| Measurements of blood pressure and electrocardiogram in conscious freely moving guineapigs: a model for screening QT interval prolongation effects. | Laboratory animals 20071001 |
| Risk factors and predictors of Torsade de pointes ventricular tachycardia in patients with left ventricular systolic dysfunction receiving Dofetilide. | The American journal of cardiology 20070901 |
| Monotherapy versus combination therapy with class III antiarrhythmic agents to attenuate transmural dispersion of repolarization: a potential risk factor for torsade de pointes. | Pharmacotherapy 20070901 |
| Combined pharmacological block of I(Kr) and I(Ks) increases short-term QT interval variability and provokes torsades de pointes. | British journal of pharmacology 20070801 |
| Double pharmacological challenge on repolarization opens new avenues for drug safety research. | British journal of pharmacology 20070801 |
| Inhibition of the HERG potassium channel by the tricyclic antidepressant doxepin. | Biochemical pharmacology 20070801 |
| Differential prognostic importance of QRS duration in heart failure and acute myocardial infarction associated with left ventricular dysfunction. | European journal of heart failure 20070801 |
| Frequency-dependent effects of various IKr blockers on cardiac action potential duration in a human atrial model. | American journal of physiology. Heart and circulatory physiology 20070701 |
| Class III antiarrhythmic methanesulfonanilides inhibit leukocyte recruitment in zebrafish. | Journal of leukocyte biology 20070701 |
| Cardioversion of persistent atrial fibrillation by a combination of atrial specific and non-specific class III drugs in the goat. | Cardiovascular research 20070701 |
| Embryonic cardiac arrhythmia and generation of reactive oxygen species: common teratogenic mechanism for IKr blocking drugs. | Reproductive toxicology (Elmsford, N.Y.) 20070701 |
| Dofetilide-induced long QT and torsades de pointes. | Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 20070701 |
| Using pharmacokinetic/pharmacodynamic modelling in safety pharmacology to better define safety margins: a regional workshop of the Safety Pharmacology Society. | Expert opinion on drug safety 20070701 |
| Fluorescently labeled analogues of dofetilide as high-affinity fluorescence polarization ligands for the human ether-a-go-go-related gene (hERG) channel. | Journal of medicinal chemistry 20070628 |
| Chronic arsenic exposure and cardiac repolarization abnormalities with QT interval prolongation in a population-based study. | Environmental health perspectives 20070501 |
| The synthesis and biological evaluation of novel series of nitrile-containing fluoroquinolones as antibacterial agents. | Bioorganic & medicinal chemistry letters 20070415 |
| The pharmacological response of ischemia-related atrial fibrillation in dogs: evidence for substrate-specific efficacy. | Cardiovascular research 20070401 |
| Calcium antagonist property of CPU228, a dofetilide derivative, contributes to its low incidence of torsades de pointes in rabbits. | Clinical and experimental pharmacology & physiology 20070401 |
| Inhibitory effects of coronary vasodilator papaverine on heterologously-expressed HERG currents in Xenopus oocytes. | Acta pharmacologica Sinica 20070401 |
| In vitro and in vivo effects of the atrial selective antiarrhythmic compound AVE1231. | Journal of cardiovascular pharmacology 20070401 |
| A novel, non-substrate-based series of glycine type 1 transporter inhibitors derived from high-throughput screening. | Bioorganic & medicinal chemistry letters 20070315 |
| Management of dofetilide overdose in a patient with known cocaine abuse. | Pharmacotherapy 20070301 |
| Observations on the safety and effectiveness of dofetilide in patients with paroxysmal atrial fibrillation and normal left ventricular function. | Journal of cardiovascular pharmacology and therapeutics 20070301 |
| Simulation of developmental changes in action potentials with ventricular cell models. | Systems and synthetic biology 20070301 |
| HERG is protected from pharmacological block by alpha-1,2-glucosyltransferase function. | The Journal of biological chemistry 20070223 |
| Proarrhythmic electrical remodelling is associated with increased beat-to-beat variability of repolarisation. | Cardiovascular research 20070201 |
| L-type calcium current reactivation contributes to arrhythmogenesis associated with action potential triangulation. | Journal of cardiovascular electrophysiology 20070201 |
| Adjunctive antiarrhythmic drug therapy in patients with implantable cardioverter defibrillators: a systematic review. | European heart journal 20070201 |
| Action potential and QT prolongation not sufficient to cause Torsade de Pointes: role of action potential triangulation. | Journal of cardiovascular electrophysiology 20070201 |
| Anti-arrhythmic effects of I (Na), I (Kr), and combined I (Kr)-I (CaL) blockade in an experimental model of acute stretch-related atrial fibrillation. | Cardiovascular drugs and therapy 20070201 |
| A novel approach to data processing of the QT interval response in the conscious telemetered beagle dog. | Journal of pharmacological and toxicological methods 20070101 |
| Pharmacological and biophysical isolation of K+ currents encoded by ether-à-go-go-related genes in murine hepatic portal vein smooth muscle cells. | American journal of physiology. Cell physiology 20070101 |
| The effect of high extracellular potassium on IKr inhibition by anti-arrhythmic agents. | Cardiology 20070101 |
| Dofetilide: a new class III antiarrhythmic agent. | Expert review of cardiovascular therapy 20070101 |
| Validation and clinical application of time-frequency analysis of atrial fibrillation electrocardiograms. | Journal of cardiovascular electrophysiology 20070101 |
| Atrial fibrillation and revascularization procedures: clinical and prognostic significance. Incidence, predictors, treatment, and long-term outcome. | Indian pacing and electrophysiology journal 20070101 |
| Towards automation of a valuable preclinical cardiac safety pharmacology assay: Evaluation of the effects of cardiac ion channel blockers on cardiac repolarisation in vitro. | Journal of pharmacological and toxicological methods 20070101 |
| Comparison of guinea-pig ventricular myocytes and dog Purkinje fibres for in vitro assessment of drug-induced delayed repolarization. | Journal of pharmacological and toxicological methods 20070101 |
| Comparison of the QT interval response during sinus and paced rhythm in conscious and anesthetized beagle dogs. | Journal of pharmacological and toxicological methods 20070101 |
| Phospholipid lysophosphatidylcholine as a metabolic trigger and HERG as an ionic pathway for extracellular K accumulation and 'short QT syndrome' in acute myocardial ischemia. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101 |
| [New antiarrhythmic agents in atrial fibrillation]. | Archivos de cardiologia de Mexico 20070101 |
| New proposals for testing drugs with IKr-blocking activity to determine their teratogenic potential. | Current pharmaceutical design 20070101 |
| A novel and lethal de novo LQT-3 mutation in a newborn with distinct molecular pharmacology and therapeutic response. | PloS one 20070101 |
| Improved functional expression of recombinant human ether-a-go-go (hERG) K+ channels by cultivation at reduced temperature. | BMC biotechnology 20070101 |
| A call for international harmonization in therapeutic risk management. | Pharmacoepidemiology and drug safety 20061201 |
| No proarrhythmic properties of the antibiotics Moxifloxacin or Azithromycin in anaesthetized dogs with chronic-AV block. | British journal of pharmacology 20061201 |
| Altering extracellular potassium concentration does not modulate drug block of human ether-a-go-go-related gene (hERG) channels. | Clinical and experimental pharmacology & physiology 20061101 |
| Atrial-specific drug AVE0118 is free of torsades de pointes in anesthetized dogs with chronic complete atrioventricular block. | Heart rhythm 20061101 |
| Different relevance of inactivation and F468 residue in the mechanisms of hEag1 channel blockage by astemizole, imipramine and dofetilide. | FEBS letters 20060918 |
| Use of a failing rabbit heart as a model to predict torsadogenicity. | Toxicological sciences : an official journal of the Society of Toxicology 20060901 |
| Overcoming HERG affinity in the discovery of the CCR5 antagonist maraviroc. | Bioorganic & medicinal chemistry letters 20060901 |
| Atrial fibrillation: choosing an antiarrhythmic drug. | Current cardiology reports 20060901 |
| Frequency of high-risk use of QT-prolonging medications. | Pharmacoepidemiology and drug safety 20060601 |
| RSD1235 blocks late INa and suppresses early afterdepolarizations and torsades de pointes induced by class III agents. | Cardiovascular research 20060601 |
| Blockade of IKs by HMR 1556 increases the reverse rate-dependence of refractoriness prolongation by dofetilide in isolated rabbit ventricles. | British journal of pharmacology 20060601 |
| Importance of extracardiac alpha1-adrenoceptor stimulation in assisting dofetilide to induce torsade de pointes in rabbit hearts. | European journal of pharmacology 20060510 |
| Molecular determinants of HERG channel block. | Molecular pharmacology 20060501 |
| Mechanisms underlying the QT interval-prolonging effects of sevoflurane and its interactions with other QT-prolonging drugs. | Anesthesiology 20060501 |
| The role of late I and antiarrhythmic drugs in EAD formation and termination in Purkinje fibers. | Journal of cardiovascular electrophysiology 20060501 |
| Antiarrhythmic drugs for maintaining sinus rhythm after cardioversion of atrial fibrillation: a systematic review of randomized controlled trials. | Archives of internal medicine 20060410 |
| Effects of dofetilide and EGIS-7229, an antiarrhythmic agent possessing class III, IV, and IB activities, on myocardial refractoriness in hyperkalemia, hypokalemia, and during beta-adrenergic activation in the rabbit papillary muscle in vitro. | Journal of pharmacological sciences 20060401 |
| An evaluation of the impact of oral magnesium lactate on the corrected QT interval of patients receiving sotalol or dofetilide to prevent atrial or ventricular tachyarrhythmia recurrence. | Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 20060401 |
| Combined use of 1C and III agents for highly symptomatic, refractory atrial fibrillation. | Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 20060401 |
| Class III effects of dofetilide and arrhythmias are modulated by [K+]o in an in vitro model of simulated-ischemia and reperfusion in guinea-pig ventricular myocardium. | European journal of pharmacology 20060227 |
| Evaluation of the rubidium efflux assay for preclinical identification of HERG blockade. | Assay and drug development technologies 20060201 |
| Application of cryopreserved cells to HERG screening using a non-radioactive Rb+ efflux assay. | Assay and drug development technologies 20060201 |
| Potassium channel subunit remodeling in rabbits exposed to long-term bradycardia or tachycardia: discrete arrhythmogenic consequences related to differential delayed-rectifier changes. | Circulation 20060124 |
| Pharmacokinetic-pharmacodynamic modeling of drug-induced effect on the QT interval in conscious telemetered dogs. | Journal of pharmacological and toxicological methods 20060101 |
| Assessment of drug-induced QT interval prolongation in conscious rabbits. | Journal of pharmacological and toxicological methods 20060101 |
| The reliability of echocardiographic left ventricular wall motion index to identify high-risk patients for multicenter studies. | Echocardiography (Mount Kisco, N.Y.) 20060101 |
| Isolated perfused and paced guinea pig heart to test for drug-induced changes of the QT interval. | Journal of pharmacological and toxicological methods 20060101 |
| Use of arterially perfused rabbit ventricular wedge in predicting arrhythmogenic potentials of drugs. | Journal of pharmacological and toxicological methods 20060101 |
| What is drug-induced long QT and what is a potential clinical consequence? | Progress in cardiovascular nursing 20060101 |
| Update of the clinical impact and issues surrounding Dofetilide (Tikosyn) therapy. | AACN advanced critical care 20060101 |
| Pharmacological treatment of atrial fibrillation: mechanisms of action and efficacy of class III drugs. | Current medicinal chemistry 20060101 |
| Effects of sex hormones on ECG parameters and expression of cardiac ion channels in dogs. | Acta physiologica (Oxford, England) 20060101 |
| A comparative study on the cost of new antibiotics and drugs of other therapeutic categories. | PloS one 20060101 |
| Safety and tolerability of oral antifungal agents in the treatment of fungal nail disease: a proven reality. | Therapeutics and clinical risk management 20051201 |
| QT prolongation and proarrhythmia by moxifloxacin: concordance of preclinical models in relation to clinical outcome. | British journal of pharmacology 20051101 |
| Statistical analysis of the DIAMOND MI study by the multipole method. | Physiological measurement 20051001 |
| Restricting excessive cardiac action potential and QT prolongation: a vital role for IKs in human ventricular muscle. | Circulation 20050906 |
| Novel potent human ether-a-go-go-related gene (hERG) potassium channel enhancers and their in vitro antiarrhythmic activity. | Molecular pharmacology 20050901 |
| Marked QT prolongation and torsades de pointes secondary to acute ischemia in an elderly man taking dofetilide for atrial fibrillation: a cautionary tale. | Journal of cardiovascular pharmacology and therapeutics 20050901 |
| Electrophysiological effects of azimilide in an in vitro model of simulated-ischemia and reperfusion in guinea-pig ventricular myocardium. | European journal of pharmacology 20050822 |
| Assessment of the proarrhythmic potential of the novel antiarrhythmic agent AZD7009 and dofetilide in experimental models of torsades de pointes. | Journal of cardiovascular electrophysiology 20050801 |
| Atypical proarrhythmia with dofetilide: monomorphic VT and exercise-induced torsade de pointes. | Pacing and clinical electrophysiology : PACE 20050801 |
| Pharmacologic control of ventricular rate: American College of Chest Physicians guidelines for the prevention and management of postoperative atrial fibrillation after cardiac surgery. | Chest 20050801 |
| Propagation of population pharmacokinetic information using a Bayesian approach: comparison with meta-analysis. | Journal of pharmacokinetics and pharmacodynamics 20050801 |
| [Long QT syndrome]. | Nihon rinsho. Japanese journal of clinical medicine 20050701 |
| Enhancing electrical cardioversion and preventing immediate reinitiation of hemodynamically deleterious atrial fibrillation with class III drug pretreatment. | Journal of cardiovascular electrophysiology 20050701 |
| A pharmacokinetic-pharmacodynamic model for the quantitative prediction of dofetilide clinical QT prolongation from human ether-a-go-go-related gene current inhibition data. | Clinical pharmacology and therapeutics 20050601 |
| Antiadrenergic therapy in the control of atrial fibrillation. | Journal of cardiovascular pharmacology and therapeutics 20050601 |
| Expert Canadian consensus suggestions on the rational, clinical use of ziprasidone in the treatment of schizophrenia and related psychotic disorders. | Neuropsychiatric disease and treatment 20050601 |
| Differential effects of human ether-a-go-go-related gene (HERG) blocking agents on QT duration variability in conscious dogs. | European journal of pharmacology 20050404 |
| [Safety of new anti-arrhythmic drugs]. | Archives des maladies du coeur et des vaisseaux 20050401 |
| Discovery of a small molecule activator of the human ether-a-go-go-related gene (HERG) cardiac K+ channel. | Molecular pharmacology 20050301 |
| The influence of extracellular acidosis on the effect of IKr blockers. | Journal of cardiovascular pharmacology and therapeutics 20050301 |
| Greater than the sum of its parts: combining models for useful ADMET prediction. | Journal of medicinal chemistry 20050224 |
| Paradoxical effect of dofetilide on action potential duration and calcium transient amplitude in newborn rabbit ventricular myocytes. | Journal of cardiovascular pharmacology 20050201 |
| pH-mediated acid stacking with reverse pressure for the analysis of cationic pharmaceuticals in capillary electrophoresis. | Electrophoresis 20050201 |
| Expression of human ERG K+ channels in the mouse heart exerts anti-arrhythmic activity. | Cardiovascular research 20050101 |
| [Atrial fibrillation: choice of the method of pharmacological cardioversion]. | Kardiologiia 20050101 |
| A new method to calculate the beat-to-beat instability of QT duration in drug-induced long QT in anesthetized dogs. | Journal of pharmacological and toxicological methods 20050101 |
| Choice of cardiac tissue plays an important role in the evaluation of drug-induced prolongation of the QT interval in vitro in rabbit. | Journal of pharmacological and toxicological methods 20050101 |
| Antiarrhythmic drugs in patients with implantable cardioverter-defibrillators. | American journal of cardiovascular drugs : drugs, devices, and other interventions 20050101 |
| Atrial fibrillation post-myocardial infarction: frequency, consequences, and management. | Current heart failure reports 20041201 |
| A benefit-risk assessment of class III antiarrhythmic agents. | Expert opinion on drug safety 20041101 |
| Role of a KCNH2 polymorphism (R1047 L) in dofetilide-induced Torsades de Pointes. | Journal of molecular and cellular cardiology 20041101 |
| Comparative pharmacology of guinea pig cardiac myocyte and cloned hERG (I(Kr)) channel. | Journal of cardiovascular electrophysiology 20041101 |
| [New anti-arrhythmics--hope or disappointment?]. | Archives des maladies du coeur et des vaisseaux 20041101 |
| 'Early' class III drugs for the treatment of atrial fibrillation: efficacy and atrial selectivity of AVE0118 in remodeled atria of the goat. | Circulation 20040928 |
| Evaluation of KCB-328, a new IKr blocking antiarrhythmic agent in pacing induced canine atrial fibrillation. | Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20040901 |
| Antiarrhythmic and proarrhythmic properties of QT-prolonging antianginal drugs. | Journal of cardiovascular pharmacology and therapeutics 20040901 |
| Evidence for gender differences in electrophysiological properties of canine Purkinje fibres. | British journal of pharmacology 20040801 |
| Structural determinants of HERG channel block by clofilium and ibutilide. | Molecular pharmacology 20040801 |
| [Perspectives and limitations in the treatment of vagus-induced atrial fibrillation. Insights from cellular pharmacology]. | Medizinische Klinik (Munich, Germany : 1983) 20040715 |
| Torsade de pointes: the clinical considerations. | International journal of cardiology 20040701 |
| Atrial-selective antiarrhythmic actions of novel Ikur vs. Ikr, Iks, and IKAch class Ic drugs and beta blockers in pigs. | Medical science monitor : international medical journal of experimental and clinical research 20040701 |
| Validation of a [3H]astemizole binding assay in HEK293 cells expressing HERG K+ channels. | Journal of pharmacological sciences 20040701 |
| Comparison of kinetic properties of quinidine and dofetilide block of HERG channels. | European journal of pharmacology 20040616 |
| Acidification alters antiarrhythmic drug blockade of the ether-a-go-go-related Gene (HERG) Channels. | Basic & clinical pharmacology & toxicology 20040501 |
| Inactivation gating determines drug potency: a common mechanism for drug blockade of HERG channels. | Acta pharmacologica Sinica 20040501 |
| Pro- and antiarrhythmic effects of fast cardiac pacing in a canine model of acquired long QT syndrome. | Naunyn-Schmiedeberg's archives of pharmacology 20040401 |
| Relationships between sinus rhythm, treatment, and survival in the Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) Study. | Circulation 20040330 |
| Influence of diabetes and diabetes-gender interaction on the risk of death in patients hospitalized with congestive heart failure. | Journal of the American College of Cardiology 20040303 |
| Cardiac ion channel effects of tolterodine. | The Journal of pharmacology and experimental therapeutics 20040301 |
| Ventricular arrhythmias triggered by alerting stimuli in conscious rabbits pre-treated with dofetilide. | Basic research in cardiology 20040301 |
| In vivo electrophysiological effects of a selective slow delayed-rectifier potassium channel blocker in anesthetized dogs: potential insights into class III actions. | Cardiovascular research 20040301 |
| Dofetilide effects on the inhibition by trains of subthreshold conditioning stimuli. | Pacing and clinical electrophysiology : PACE 20040301 |
| The utility of hERG and repolarization assays in evaluating delayed cardiac repolarization: influence of multi-channel block. | Journal of cardiovascular pharmacology 20040301 |
| Antiarrhythmic drug therapy of atrial fibrillation. | Cardiology clinics 20040201 |
| [Pathophysiology and clinical management of atrial flatter]. | Orvosi hetilap 20040125 |
| Tetrahydronaphthalene-derived amino alcohols and amino ketones as potent and selective inhibitors of the delayed rectifier potassium current IKs. | Bioorganic & medicinal chemistry letters 20040105 |
| Oral class III antiarrhythmics: what is new? | Current opinion in cardiology 20040101 |
| Trials of new antiarrhythmic drugs for maintenance of sinus rhythm in patients with atrial fibrillation. | Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 20040101 |
| Theoretical possibilities for the development of novel antiarrhythmic drugs. | Current medicinal chemistry 20040101 |
| QT and JT dispersion in the drug-induced long QT syndrome in anaesthetized rabbits is accurately detected by a three-lead surface ECG measurement. | Journal of pharmacological and toxicological methods 20040101 |
| HERG K channel conductance promotes H2O2-induced apoptosis in HEK293 cells: cellular mechanisms. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20040101 |
| Phase IV trial evaluating the effectiveness and safety of dofetilide. | The Annals of pharmacotherapy 20040101 |
| Clinical review: clinical management of atrial fibrillation - rate control versus rhythm control. | Critical care (London, England) 20040101 |
| Recent developments in cardiovascular drug therapy: treatment of atrial arrhythmias with new class III drugs and beyond. | Current medicinal chemistry. Cardiovascular and hematological agents 20040101 |
| The [3H]dofetilide binding assay is a predictive screening tool for hERG blockade and proarrhythmia: Comparison of intact cell and membrane preparations and effects of altering [K+]o. | Journal of pharmacological and toxicological methods 20040101 |
| Atrial fibrillation in the heart failure population. | The Journal of cardiovascular nursing 20040101 |
| Pharmacological cardioversion of atrial fibrillation: current management and treatment options. | Drugs 20040101 |
| Minimally invasive atrial fibrillation ablation combined with a new technique for thoracoscopic stapling of the left atrial appendage: case report. | The heart surgery forum 20040101 |
| Management of atrial fibrillation: review of the evidence for the role of pharmacologic therapy, electrical cardioversion, and echocardiography. | Annals of internal medicine 20031216 |
| The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20031201 |
| Atrial stunning: basics and clinical considerations. | International journal of cardiology 20031201 |
| Introduction--roundtable on atrial fibrillation: update on mechanisms and approaches to treatment. | Journal of cardiovascular electrophysiology 20031201 |
| Clinical experience with dofetilide in the treatment of patients with atrial fibrillation. | Journal of cardiovascular electrophysiology 20031201 |
| Initiation and monitoring of class III antiarrhythmic agents. | Journal of cardiovascular electrophysiology 20031201 |
| Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia. | British journal of cancer 20031117 |
| Electrophysiological safety of sertindole in dogs with normal and remodeled hearts. | The Journal of pharmacology and experimental therapeutics 20031101 |
| Differential recovery of action potential duration and HERG currents from the effects of two methanesulfonamide class III antiarrhythmic agents, KCB-328 and dofetilide. | Journal of cardiovascular pharmacology 20031101 |
| Evaluation of the dofetilide risk-management program. | American heart journal 20031101 |
| Atrial effects of the novel K(+)-channel-blocker AVE0118 in anesthetized pigs. | Cardiovascular research 20031101 |
| The cholinomimetic agent bethanechol activates IK(ACh) in feline atrial myocytes. | Naunyn-Schmiedeberg's archives of pharmacology 20031001 |
| A review of clinical trials assessing the efficacy and safety of newer antiarrhythmic drugs in atrial fibrillation. | Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 20031001 |
| New antiarrhythmic agents for atrial fibrillation and atrial flutter: United States drug market response as an indicator of acceptance. | Pharmacotherapy 20031001 |
| [Progress in the clinical use of anti-arrhythmic drugs (I)]. | Zhonghua er ke za zhi = Chinese journal of pediatrics 20031001 |
| IKr channel blockers: novel antiarrhythmic agents. | Current medicinal chemistry. Cardiovascular and hematological agents 20031001 |
| Blockers of the slowly delayed rectifier potassium IKs channel: potential antiarrhythmic agents. | Current medicinal chemistry. Cardiovascular and hematological agents 20031001 |
| Pure class III agents for prevention of sudden cardiac death. | Journal of cardiovascular electrophysiology 20030901 |
| Does conversion and prevention of atrial fibrillation enhance survival in patients with left ventricular dysfunction? Evidence from the Danish Investigations of Arrhythmia and Mortality ON Dofetilide/(DIAMOND) study. | Cardiac electrophysiology review 20030901 |
| Role of dofetilide in patients with atrial fibrillation. Insights from the Symptomatic Atrial Fibrillation Investigative Research on Dofetilide (SAFIRE-D) study. | Cardiac electrophysiology review 20030901 |
| Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. | Bioorganic & medicinal chemistry letters 20030818 |
| Beta-adrenoceptor activation plays a role in the reverse rate-dependency of effective refractory period lengthening by dofetilide in the guinea-pig atrium, in vitro. | British journal of pharmacology 20030802 |
| Developmental changes in IKr and IKs contribute to age-related expression of dofetilide effects on repolarization and proarrhythmia. | Cardiovascular research 20030801 |
| Asynchronous development of electrical remodeling and cardiac hypertrophy in the complete AV block dog. | Cardiovascular research 20030801 |
| Modulation of ventricular fibrillation in isolated perfused heart by dofetilide. | Journal of cardiovascular pharmacology 20030601 |
| Dofetilide: a new drug to control cardiac arrhythmia. | Expert opinion on pharmacotherapy 20030601 |
| [Effects of clinically available drugs on the repolarization process of the heart assessed by the in vivo canine models]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20030601 |
| Block of HERG-carried K+ currents by the new repolarization delaying agent H 345/52. | Journal of cardiovascular electrophysiology 20030601 |
| Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches. | Bioorganic & medicinal chemistry letters 20030519 |
| Differences in electrophysiological and contractile properties of mammalian cardiac tissues bathed in bicarbonate - and HEPES-buffered solutions. | Acta physiologica Scandinavica 20030501 |
| The prognostic value of QTc interval and QT dispersion following myocardial infarction in patients treated with or without dofetilide. | Clinical cardiology 20030501 |
| Famotidine does not induce long QT syndrome: experimental evidence from in vitro and in vivo test systems. | European journal of pharmacology 20030411 |
| Old and new antiarrhythmic drugs for converting and maintaining sinus rhythm in atrial fibrillation: comparative efficacy and results of trials. | The American journal of cardiology 20030320 |
| Pharmacologic and nonpharmacologic options to maintain sinus rhythm: guideline-based and new approaches. | The American journal of cardiology 20030320 |
| Risk of proarrhythmia with class III antiarrhythmic agents: sex-based differences and other issues. | The American journal of cardiology 20030320 |
| Effects of antiarrhythmic drugs on fibrillation in the remodeled atrium: insights into the mechanism of the superior efficacy of amiodarone. | Circulation 20030318 |
| Dissociation of E-4031 from the HERG channel caused by mutations of an amino acid results in greater block at high stimulation frequency. | Cardiovascular research 20030301 |
| Detection of proarrhythmia in the female rabbit heart: blinded validation. | Journal of cardiovascular electrophysiology 20030301 |
| Overexpression of calcineurin in mouse causes sudden cardiac death associated with decreased density of K+ channels. | Cardiovascular research 20030201 |
| Dofetilide and atrial fibrillation. | The American journal of nursing 20030201 |
| Survival after withdrawal of dofetilide in patients with congestive heart failure and a short baseline QTc interval; a follow-up on the Diamond-CHF QT substudy. | European heart journal 20030201 |
| Management of arrhythmias in heart failure. | Congestive heart failure (Greenwich, Conn.) 20030101 |
| Potentially significant drug interactions of class III antiarrhythmic drugs. | Drug safety 20030101 |
| Effect of HERG-like potassium channel blocker on the carotid body chemoreception. | Advances in experimental medicine and biology 20030101 |
| Prevalence, prognostic significance, and treatment of atrial fibrillation in congestive heart failure with particular reference to the DIAMOND-CHF study. | Congestive heart failure (Greenwich, Conn.) 20030101 |
| [Development of original Russian antiarrhythmic drugs of the 3rd class]. | Vestnik Rossiiskoi akademii meditsinskikh nauk 20030101 |
| Role of atrial fibrillation threshold evaluation on guiding treatment. | Indian pacing and electrophysiology journal 20030101 |
| Preventing sudden death and the use of prophylactic implanted defibrillators. | Indian pacing and electrophysiology journal 20030101 |
| Atrial remodeling: evolving concepts. | Indian pacing and electrophysiology journal 20030101 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20021201 |
| Electrophysiological and antiarrhythmic effects of the novel I(Kur) channel blockers, S9947 and S20951, on left vs. right pig atrium in vivo in comparison with the I(Kr) blockers dofetilide, azimilide, d,l-sotalol and ibutilide. | Naunyn-Schmiedeberg's archives of pharmacology 20021101 |
| Combined endpoints: can we use them? | Statistics in medicine 20021015 |
| Testosterone diminishes the proarrhythmic effects of dofetilide in normal female rabbits. | Circulation 20021015 |
| Drug-induced long QT in isolated rabbit Purkinje fibers: importance of action potential duration, triangulation and early afterdepolarizations. | European journal of pharmacology 20021004 |
| Interaction of different potassium channels in cardiac repolarization in dog ventricular preparations: role of repolarization reserve. | British journal of pharmacology 20021001 |
| Pfizer allows community pharmacies to dispense dofetilide. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20020915 |
| Maintaining stability of sinus rhythm in atrial fibrillation: antiarrhythmic drugs versus ablation. | Current cardiology reports 20020901 |
| QT interval dynamics predict mortality in high-risk patients after myocardial infarction. | Scandinavian cardiovascular journal : SCJ 20020901 |
| Practitioner acceptance of the dofetilide risk-management program. | Pharmacotherapy 20020801 |
| The functional properties of the human ether-à-go-go-like (HELK2) K+ channel. | The European journal of neuroscience 20020801 |
| How to enhance acute outcome of electrical cardioversion by drug therapy: importance of immediate reinitiation of atrial fibrillation. | Journal of cardiovascular electrophysiology 20020801 |
| [Synthesis and vasorelaxant activities of benzopyran-4-one hydrazone derivatives]. | Yao xue xue bao = Acta pharmaceutica Sinica 20020801 |
| New p-methylsulfonamido phenylethylamine analogues as class III antiarrhythmic agents: design, synthesis, biological assay, and 3D-QSAR analysis. | Journal of medicinal chemistry 20020704 |
| Transient atrial mechanical dysfunction (stunning) after cardioversion of atrial fibrillation and flutter. | American heart journal 20020701 |
| Prevention of and medical therapy for atrial arrhythmias in heart failure. | Heart failure reviews 20020701 |
| Significance and control of cardiac arrhythmias in patients with congestive cardiac failure. | Heart failure reviews 20020701 |
| A randomised cross-over study on the haemodynamic effects of oral dofetilide compared with oral sotalol in patients with ischaemic heart disease and sustained ventricular tachycardia. | European journal of clinical pharmacology 20020601 |
| [Atrial fibrillation in heart failure]. | Herz 20020601 |
| Effects of dofetilide on cardiovascular tissues from normo- and hypertensive rats. | The Journal of pharmacy and pharmacology 20020501 |
| Protein kinase A-mediated phosphorylation of HERG potassium channels in a human cell line. | Chinese medical journal 20020501 |
| Evaluation of Pulsincap to provide regional delivery of dofetilide to the human GI tract. | International journal of pharmaceutics 20020402 |
| A comparison of currents carried by HERG, with and without coexpression of MiRP1, and the native rapid delayed rectifier current. Is MiRP1 the missing link? | The Journal of physiology 20020401 |
| Electrophysiological mechanism of enhanced susceptibility of hypertrophied heart to acquired torsade de pointes arrhythmias: tridimensional mapping of activation and recovery patterns. | Circulation 20020305 |
| Effects of the I(Kr)-blocking agent dofetilide and of the I(Ks)-blocking agent chromanol 293b on regional disparity of left ventricular repolarization in the intact canine heart. | Journal of cardiovascular pharmacology 20020301 |
| Antidysrhythmic agents at the turn of the twenty-first century: a current review. | Critical care nursing clinics of North America 20020301 |
| Effect of dofetilide on QT dispersion and the prognostic implications of changes in QT dispersion for patients with congestive heart failure. | European journal of heart failure 20020301 |
| Sex, hormones, and repolarization. | Cardiovascular research 20020215 |
| Dofetilide block involves interactions with open and inactivated states of HERG channels. | Pflugers Archiv : European journal of physiology 20020201 |
| New antiarrhythmic drugs for the treatment of atrial fibrillation. | Pacing and clinical electrophysiology : PACE 20020201 |
| Management of arrhythmias in heart failure. | Cardiology in review 20020101 |
| Pharmacodynamic effect of continuous vs intermittent dosing of dofetilide on QT interval. | British journal of clinical pharmacology 20020101 |
| Vascular effects of class-III antiarrhythmic drugs: chromanol 293B, but not dofetilide blocks the smooth muscle delayed rectifier K+ channel. | Basic research in cardiology 20020101 |
| A benefit-risk assessment of class III antiarrhythmic agents. | Drug safety 20020101 |
| Tachycardiomyopathy. | Indian pacing and electrophysiology journal 20020101 |
| Molecular determinants of inactivation and dofetilide block in ether a-go-go (EAG) channels and EAG-related K(+) channels. | Molecular pharmacology 20011201 |
| A review of class III antiarrhythmic agents for atrial fibrillation: maintenance of normal sinus rhythm. | Pharmacotherapy 20011201 |
| Effects of the class III antiarrhythmic agent dofetilide (UK-68,798) on L-type calcium current from rabbit ventricular myocytes. | The Journal of pharmacy and pharmacology 20011201 |
| Dofetilide: what role in the treatment of ventricular tachyarrhythmias? | European heart journal 20011201 |
| A multicentre, double-blind randomized crossover comparative study on the efficacy and safety of dofetilide vs sotalol in patients with inducible sustained ventricular tachycardia and ischaemic heart disease. | European heart journal 20011201 |
| Effects of intravenous dofetilide on induction of atrioventricular re-entrant tachycardia. | Heart (British Cardiac Society) 20011101 |
| Drug block of I(kr): model systems and relevance to human arrhythmias. | Journal of cardiovascular pharmacology 20011101 |
| Transient kinetic and dynamic interactions between verapamil and dofetilide, a class III antiarrhythmic. | Journal of clinical pharmacology 20011101 |
| Practical approach to the use and monitoring of dofetilide therapy. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20011101 |
| [3H]dofetilide binding to HERG transfected membranes: a potential high throughput preclinical screen. | European journal of pharmacology 20011026 |
| Development and evaluation of high throughput functional assay methods for HERG potassium channel. | Journal of biomolecular screening 20011001 |
| Is it rational, reasonable or excessive, and consistently applied? One view of the increasing FDA emphasis on safety first for the release and use of antiarrhythmic drugs for supraventricular arrhythmias. | Journal of cardiovascular pharmacology and therapeutics 20011001 |
| Pericardioversion dofetilide does not suppress immediate and subacute recurrences of persistent atrial fibrillation. | Circulation 20010911 |
| Efficacy of azimilide and dofetilide in the dog right atrial enlargement model of atrial flutter. | Journal of cardiovascular electrophysiology 20010901 |
| A randomized, double-blind, placebo-controlled evaluation of the efficacy and safety of intravenously administered dofetilide in patients with Wolff-Parkinson-White syndrome. | Pacing and clinical electrophysiology : PACE 20010801 |
| Efficacy of dofetilide in the treatment of atrial fibrillation-flutter in patients with reduced left ventricular function: a Danish investigations of arrhythmia and mortality on dofetilide (diamond) substudy. | Circulation 20010717 |
| What niche will newer class III antiarrhythmic drugs occupy? | Current cardiology reports 20010701 |
| Efficacy and safety of dofetilide in the prevention of symptomatic episodes of paroxysmal supraventricular tachycardia: a 6-month double-blind comparison with propafenone and placebo. | American heart journal 20010701 |
| 'Use-dependent' effects of cisapride on postrest action potentials in rabbit ventricular myocardium. | European journal of pharmacology 20010622 |
| Three things you should know when considering the atria: location, location, location. | Circulation research 20010608 |
| Potential ionic mechanism for repolarization differences between canine right and left atrium. | Circulation research 20010608 |
| Class III antiarrhythmics and phenytoin: teratogenicity due to embryonic cardiac dysrhythmia and reoxygenation damage. | Current pharmaceutical design 20010601 |
| Cardiac and hemodynamic effects of intravenous dofetilide in patients with heart failure. | The American journal of cardiology 20010601 |
| Impact of sex and gonadal steroids on prolongation of ventricular repolarization and arrhythmias induced by I(K)-blocking drugs. | Circulation 20010501 |
| Transgenic mice overexpressing human KvLQT1 dominant-negative isoform. Part II: Pharmacological profile. | Cardiovascular research 20010501 |
| Role of antiarrhythmic therapy in patients at risk for sudden cardiac death: an evidence-based review. | Pharmacotherapy 20010501 |
| Female gender is a risk factor for drug-induced long QT and cardiac arrhythmias in an in vivo rabbit model. | Journal of cardiovascular electrophysiology 20010501 |
| Comparison of the rate dependent effects of dofetilide and ibutilide in the newborn heart. | Pacing and clinical electrophysiology : PACE 20010501 |
| Mechanisms of antiarrhythmic drug action on termination of atrial flutter. | Pacing and clinical electrophysiology : PACE 20010501 |
| Tedisamil and dofetilide-induced torsades de pointes, rate and potassium dependence. | British journal of pharmacology 20010401 |
| The class III antiarrhythmic drugs dofetilide and sotalol prevent AF induction by atrial premature complexes at doses that fail to terminate AF. | Cardiovascular research 20010401 |
| Modulation of rat erg1, erg2, erg3 and HERG K+ currents by thyrotropin-releasing hormone in anterior pituitary cells via the native signal cascade. | The Journal of physiology 20010401 |
| Dofetilide (Tikosyn): a new drug to control atrial fibrillation. | Cleveland Clinic journal of medicine 20010401 |
| Importance of QT interval determination and renal function assessment during antiarrhythmic drug therapy. | Journal of cardiovascular pharmacology and therapeutics 20010401 |
| Left ventricular hypertrophy decreases slowly but not rapidly activating delayed rectifier potassium currents of epicardial and endocardial myocytes in rabbits. | Circulation 20010320 |
| Pause-dependent polymorphic ventricular tachycardia during long-term treatment with dofetilide: a placebo-controlled, implantable cardioverter-defibrillator-based evaluation. | Journal of the American College of Cardiology 20010315 |
| Dofetilide: is the treatment worse than the disease? | Journal of the American College of Cardiology 20010315 |
| Qtc interval as a guide to select those patients with congestive heart failure and reduced left ventricular systolic function who will benefit from antiarrhythmic treatment with dofetilide. | Circulation 20010313 |
| [Efficacy and safety of oral dofetilide in converting to and maintaining sinus rhythm in patients with chronic atrial fibrillation or atrial flutter]. | Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology 20010301 |
| Myocardial repolarization and drugs. Impossibility to predict the dominance of anti-arrhythmic over pro-arrhythmic effects of drugs due to differential and ventricular electrical remodeling. | Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20010301 |
| Qt dispersion has no prognostic information for patients with advanced congestive heart failure and reduced left ventricular systolic function. | Circulation 20010213 |
| [3H]dofetilide binding in SHSY5Y and HEK293 cells expressing a HERG-like K+ channel? | European journal of pharmacology 20010202 |
| Pharmacologic management of atrial fibrillation: current therapeutic strategies. | American heart journal 20010201 |
| Differential effects of dofetilide, amiodarone, and class lc drugs on left and right atrial refractoriness and left atrial vulnerability in pigs. | Naunyn-Schmiedeberg's archives of pharmacology 20010201 |
| Azimilide and dofetilide produce similar electrophysiological and proarrhythmic effects in a canine model of Torsade de Pointes arrhythmias. | European journal of pharmacology 20010119 |
| Effect of dofetilide on the pharmacokinetics of digoxin. | The American journal of cardiology 20010115 |
| Intravenous antiarrhythmic agents. | Current opinion in cardiology 20010101 |
| Effects of EGIS-7229 (S 21407), a novel class III antiarrhythmic drug, on myocardial refractoriness to electrical stimulation in vivo and in vitro. | Journal of cardiovascular pharmacology 20010101 |
| Dofetilide: a new class III antiarrhythmic agent. | The Canadian journal of cardiology 20010101 |
| pH-mediated field-amplified sample stacking of pharmaceutical cations in high-ionic strength samples. | Electrophoresis 20010101 |
| Species plays an important role in drug-induced prolongation of action potential duration and early afterdepolarizations in isolated Purkinje fibers. | Journal of cardiovascular electrophysiology 20010101 |
| How to manage atrial fibrillation: an update on recent clinical trials. | Cardiology in review 20010101 |
| Dofetilide: a new class III antiarrhythmic for the management of atrial fibrillation. | Progress in cardiovascular nursing 20010101 |
| Newer antiarrhythmic drugs. | Indian heart journal 20010101 |
| New antiarrhythmic agents for atrial fibrillation. | Current opinion in investigational drugs (London, England : 2000) 20010101 |
| KCB-328 (C&C Research Labs). | Current opinion in investigational drugs (London, England : 2000) 20010101 |
| Current management of symptomatic atrial fibrillation. | Drugs 20010101 |
| Pharmacologic conversion of atrial fibrillation: a systematic review of available evidence. | Progress in cardiovascular diseases 20010101 |
| Frequency dependent prolongation of effective refractory period by a complex class III antiarrhythmic agent CPU-86017. | Acta pharmacologica Sinica 20010101 |
| Pharmacological blockade of ERG K(+) channels and Ca(2+) influx through store-operated channels exerts opposite effects on intracellular Ca(2+) oscillations in pituitary GH(3) cells. | Molecular pharmacology 20001101 |
| Dofetilide: A new antiarrhythmic agent approved for conversion and/or maintenance of atrial fibrillation/atrial flutter. | Drugs of today (Barcelona, Spain : 1998) 20001101 |
| Positive atrial inotropic effect of dofetilide after cardioversion of atrial fibrillation or flutter. | The American journal of cardiology 20000915 |
| Dofetilide, a new class III antiarrhythmic agent. | Pharmacotherapy 20000701 |
| Redox state dependency of HERGS631C channel pharmacology: relation to C-type inactivation. | FEBS letters 20000526 |
| Dofetilide: a review of its use in atrial fibrillation and atrial flutter. | Drugs 19991201 |
| Dofetilide in patients with congestive heart failure and left ventricular dysfunction. Danish Investigations of Arrhythmia and Mortality on Dofetilide Study Group. | The New England journal of medicine 19990916 |
| Dynamic analysis of dofetilide-induced changes in ventricular repolarization. | Clinical pharmacology and therapeutics 19980901 |
| A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG. | FEBS letters 19971103 |
| Electrophysiologic profile and efficacy of intravenous dofetilide (UK-68,798), a new class III antiarrhythmic drug, in patients with sustained monomorphic ventricular tachycardia. Dofetilide Arrhythmia Study Group. | The American journal of cardiology 19951115 |
Related Products
Featured Products
© 2019 Angene International Limited. All rights Reserved.