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115044-75-2 | Adenosine, 2-chloro-3'-deoxy-
CAS No: 115044-75-2 Catalog No: AG000FR4 MDL No:
Product Description
Catalog Number:
AG000FR4
Chemical Name:
Adenosine, 2-chloro-3'-deoxy-
CAS Number:
115044-75-2
Molecular Formula:
C10H12ClN5O3
Molecular Weight:
285.6870
IUPAC Name:
(2R,3R,5S)-2-(6-amino-2-chloropurin-9-yl)-5-(hydroxymethyl)oxolan-3-ol
InChI:
InChI=1S/C10H12ClN5O3/c11-10-14-7(12)6-8(15-10)16(3-13-6)9-5(18)1-4(2-17)19-9/h3-5,9,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,9+/m0/s1
InChI Key:
HNSLUZJFGNTTEV-OBXARNEKSA-N
SMILES:
OC[C@@H]1C[C@H]([C@@H](O1)n1cnc2c1nc(Cl)nc2N)O
UNII:
JYW18Y92UP
Properties
Complexity:
338
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
3
Defined Bond Stereocenter Count:
0
Exact Mass:
285.063g/mol
Formal Charge:
0
Heavy Atom Count:
19
Hydrogen Bond Acceptor Count:
7
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
285.688g/mol
Monoisotopic Mass:
285.063g/mol
Rotatable Bond Count:
2
Topological Polar Surface Area:
119A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0.3
Literature
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|---|---|
| Myasthenia gravis, an autoimmune manifestation of lymphoma and lymphoproliferative disorders: case reports and review of literature. | Leukemia & lymphoma 20120301 |
| Hairy cell leukemia: evaluation of the long-term outcome in 121 patients. | Cancer 20101015 |
| Outcome of pediatric patients with Langerhans cell histiocytosis treated with 2 chlorodeoxyadenosine: a nationwide survey in Japan. | International journal of hematology 20100501 |
| Significant efficacy of 2-CdA with or without rituximab in the treatment of splenic marginal zone lymphoma (SMZL). | Annals of oncology : official journal of the European Society for Medical Oncology 20100401 |
| Extranodal multifocal Rosai-Dorfman disease: response to 2-chlorodeoxyadenosine treatment. | International journal of hematology 20090101 |
| Successful treatment of warm antibody (IgG/C3 positive) autoimmune hemolytic anemia in hairy-cell leukemia with 2-CdA in the elderly. | Leukemia & lymphoma 20080701 |
| Activity and toxicity of 2-CDA in Langerhans cell histiocytosis: a single institutional experience. | Indian journal of cancer 20070101 |
| Complete remission of hairy cell leukemia variant (HCL-v) complicated by red cell aplasia post treatment with rituximab. | Haematologica 20051101 |
| Bilateral facial nerve palsy as first indication of relapsing hairy cell leukemia after 36 years. | Neurology 20040727 |
| Factors affecting bryostatin 1-enhanced 2-CdA cytotoxicity in resistant B-cell chronic lymphocytic leukemia. | International journal of molecular medicine 20040701 |
| Low dose 2-CdA schedule activity in splenic marginal zone lymphomas. | Hematological oncology 20031201 |
| Inactivation of deoxycytidine kinase and overexpression of P-glycoprotein in AraC and daunorubicin double resistant leukemic cell lines. | Leukemia research 20030501 |
| Induction of apoptosis in the human mast cell leukemia cell line HMC-1 by various antineoplastic drugs. | Leukemia & lymphoma 20030301 |
| Synthesis and induction of apoptosis in B cell chronic leukemia by diosgenyl 2-amino-2-deoxy-beta-D-glucopyranoside hydrochloride and its derivatives. | Carbohydrate research 20030120 |
| 2-CdA in the treatment of hairy cell leukaemia. | The Journal of the Association of Physicians of India 20010801 |
| Nucleoside analogues: mechanisms of drug resistance and reversal strategies. | Leukemia 20010601 |
| Treatment-induced expression of anti-apoptotic proteins in WSU-CLL, a human chronic lymphocytic leukemia cell line. | Journal of drug targeting 20010101 |
| Synthesis of the 2-chloro analogues of 3'-deoxyadenosine, 2',3'-dideoxyadenosine, and 2',3'-didehydro-2',3'-dideoxyadenosine as potential antiviral agents. | Journal of medicinal chemistry 19890501 |
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