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1146648-86-3 | 4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexan-1-ol hydrochloride
CAS No: 1146648-86-3 Catalog No: AG01FMI5 MDL No:MFCD01102901
Product Description
Catalog Number:
AG01FMI5
Chemical Name:
4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexan-1-ol hydrochloride
CAS Number:
1146648-86-3
Molecular Formula:
C13H19Br2ClN2O
Molecular Weight:
414.5638
MDL Number:
MFCD01102901
IUPAC Name:
4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol;hydrochloride
InChI:
InChI=1S/C13H18Br2N2O.ClH/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10;/h5-6,10-11,17-18H,1-4,7,16H2;1H
InChI Key:
QNVKOSLOVOTXKF-UHFFFAOYSA-N
SMILES:
OC1CCC(CC1)NCc1cc(Br)cc(c1N)Br.Cl
EC Number:
245-899-2
UNII:
CC995ZMV90
NSC Number:
758224
Properties
Complexity:
259
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
413.953g/mol
Formal Charge:
0
Heavy Atom Count:
19
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
4
Isotope Atom Count:
0
Molecular Weight:
414.566g/mol
Monoisotopic Mass:
411.955g/mol
Rotatable Bond Count:
3
Topological Polar Surface Area:
58.3A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| Effects of ambroxol on Candida albicans growth and biofilm formation. | Mycoses 20140401 |
| [Study of sustained-matrix tablets Ambroxol hydrochloride and potential impact of different fillers on the matrix tablet's scale-up]. | Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20121018 |
| β-Cyclodextrin enhanced on-line organic solvent field-amplified sample stacking in capillary zone electrophoresis for analysis of ambroxol in human plasma, following liquid-liquid extraction in the 96-well format. | Journal of pharmaceutical and biomedical analysis 20120701 |
| Effects of antenatal application of ambroxol and glucocorticoid on lung morphometry and signal transduction of bone morphogenetic protein in the fetal rat. | Molecular medicine reports 20120701 |
| Ambroxol influences voriconazole resistance of Candida parapsilosis biofilm. | FEMS yeast research 20120601 |
| [Notes on syrups and dry syrups of ambroxol hydrochloride and L-carbocysteine]. | Arerugi = [Allergy] 20120501 |
| Anti-asthmatic agents alleviate pulmonary edema by upregulating AQP1 and AQP5 expression in the lungs of mice with OVA-induced asthma. | Respiratory physiology & neurobiology 20120415 |
| High-dose ambroxol reduces pulmonary complications in patients with acute cervical spinal cord injury after surgery. | Neurocritical care 20120401 |
| 9,10-Phenanthrenequinone promotes secretion of pulmonary aldo-keto reductases with surfactant. | Cell and tissue research 20120201 |
| On-line sample cleanup and enrichment chromatographic technique for the determination of ambroxol in human serum. | Journal of chromatographic science 20120201 |
| Simple transmission Raman measurements using a single multivariate model for analysis of pharmaceutical samples contained in capsules of different colors. | Talanta 20120130 |
| In vitro characterization and release study of Ambroxol hydrochloride matrix tablets prepared by direct compression. | Pharmaceutical development and technology 20120101 |
| The differential effect of intrathecal Nav1.8 blockers on the induction and maintenance of capsaicin- and peripheral ischemia-induced mechanical allodynia and thermal hyperalgesia. | Anesthesia and analgesia 20120101 |
| Recurrent acute rhinosinusitis: a single blind clinical study of N-acetylcysteine vs ambroxol associated to corticosteroid therapy. | International journal of immunopathology and pharmacology 20120101 |
| [Soluble guanylate cyclase in the molecular mechanism underlying the therapeutic action of drugs]. | Biomeditsinskaia khimiia 20120101 |
| Factors affecting the bitterness intensities of ten commercial formulations of ambroxol. | Chemical & pharmaceutical bulletin 20120101 |
| Effects of guaifenesin, N-acetylcysteine, and ambroxol on MUC5AC and mucociliary transport in primary differentiated human tracheal-bronchial cells. | Respiratory research 20120101 |
| [Optimization of a floating osmotic pump system of ambroxol hydrochloride using central composite design-response surface methodology and its pharmacokinetics in Beagle dogs]. | Yao xue xue bao = Acta pharmaceutica Sinica 20111201 |
| [Clinical observation of mucoregulatory agents' application after chronic rhinosinusitis surgery]. | Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery 20111001 |
| High performance liquid chromatographic method for the determination of cetirizine and ambroxol in human plasma and urine--a boxcar approach. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110901 |
| Design and evaluation of osmotic pump-based controlled release system of Ambroxol Hydrochloride. | Pharmaceutical development and technology 20110801 |
| Fast-track pulmonary conditioning before urgent cardiac surgery in patients with insufficiently treated chronic obstructive pulmonary disease. | The Journal of cardiovascular surgery 20110801 |
| The diabetic foot: an overview of assessment and complications. | British journal of nursing (Mark Allen Publishing) 20110801 |
| [Effects of ambroxol combined with low-dose heparin on TNF-alpha and IL-1beta in rabbits with acute lung injury]. | Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20110501 |
| Possible involvement of tetrodotoxin-resistant sodium channels in cough reflex. | European journal of pharmacology 20110210 |
| [A case of pulmonary tumor thrombotic microangiopathy induced by early gastric cancer]. | Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20110201 |
| Characterization of the ERAD process of the L444P mutant glucocerebrosidase variant. | Blood cells, molecules & diseases 20110115 |
| Formulation development of ambroxol hydrochloride soft gel with application of statistical experimental design and response surface methodology. | PDA journal of pharmaceutical science and technology 20110101 |
| Effect of ambroxol on pneumonia caused by Pseudomonas aeruginosa with biofilm formation in an endotracheal intubation rat model. | Chemotherapy 20110101 |
| Protective effect of ambroxol against paraquat-induced pulmonary fibrosis in rats. | Internal medicine (Tokyo, Japan) 20110101 |
| [Antenatal ambroxol administration for prevention of respiratopry distress syndrome in preterm infants: preliminary report]. | Akusherstvo i ginekologiia 20110101 |
| [Treatment of preterm delivery--therapeutic algorithm]. | Akusherstvo i ginekologiia 20110101 |
| Antinociceptive effect of ambroxol in rats with neuropathic spinal cord injury pain. | Pharmacology, biochemistry, and behavior 20101201 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| [Ambroxol for the prevention of respiratory distress syndrome in preterm infants: a meta analysis]. | Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20101101 |
| [Effect of ambroxol on lung development of rat models with nitrofen-induced congenital diaphragmatic hernia]. | Zhonghua yi xue za zhi 20100914 |
| The protective effects of ambroxol on radiation lung injury and influence on production of transforming growth factor beta1 and tumor necrosis factor alpha. | Medical oncology (Northwood, London, England) 20100901 |
| Colorimetric and atomic absorption spectrometric determination of mucolytic drug ambroxol through ion-pair formation with iron and thiocyanate. | Combinatorial chemistry & high throughput screening 20100901 |
| Ambroxol interferes with Pseudomonas aeruginosa quorum sensing. | International journal of antimicrobial agents 20100901 |
| Removal of an aspirated foreign body with a flexible cryoprobe. | Respiratory care 20100801 |
| ES936 stimulates DNA synthesis in HeLa cells independently on NAD(P)H:quinone oxidoreductase 1 inhibition, through a mechanism involving p38 MAPK. | Chemico-biological interactions 20100730 |
| Block of sensory neuronal Na+ channels by the secreolytic ambroxol is associated with an interaction with local anesthetic binding sites. | European journal of pharmacology 20100325 |
| [Obstruction of the upper respiratory tract by a subglottic expansive lesion--a case of emergency]. | Laryngo- rhino- otologie 20100101 |
| An oral controlled release system for ambroxol hydrochloride containing a wax and a water insoluble polymer. | Pharmaceutical development and technology 20100101 |
| Stability-indicating HPTLC determination of ambroxol hydrochloride in bulk drug and pharmaceutical dosage form. | Journal of chromatographic science 20100101 |
| Effects of certain antioxidants on lipid peroxidation process in lung homogenates of L thyroxine-receiving rats. | Neuro endocrinology letters 20100101 |
| [Clinical research on high-dosage ambroxol hydrochloride associated with ulinastatin in improvement of lung tissue injury of patients with paraquat poisoning]. | Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20100101 |
| [Effect of mucolytic therapy on the production of reactive oxygen species in the blood of patients with an exacerbation of chronic obstructive pulmonary disease]. | Terapevticheskii arkhiv 20100101 |
| Clinical efficacy of farcosolvin syrup (ambroxol-theophylline-guaiphenesin mixture) in the treatment of acute exacerbation of chronic bronchitis. | International journal of chronic obstructive pulmonary disease 20100101 |
| [Efficacy of different dosages of ambroxol hydrochloride in the prevention of neonatal respiratory distress syndrome]. | Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20090901 |
| Transepithelial transport of ambroxol hydrochloride across human intestinal Caco-2 cell monolayers. | General physiology and biophysics 20090901 |
| Identification and characterization of ambroxol as an enzyme enhancement agent for Gaucher disease. | The Journal of biological chemistry 20090828 |
| Unclear loss of consciousness after clobutinol intake. | Forensic science international 20090810 |
| [Effects of ambroxol on renal function in children undergoing cardiopulmonary bypass]. | Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20090801 |
| Pulmonary selectivity and local pharmacokinetics of ambroxol hydrochloride dry powder inhalation in rat. | Journal of pharmaceutical sciences 20090501 |
| Ambroxol lozenges: new drug. Sore throat: better to just suck on hard candy. | Prescrire international 20090401 |
| Action of N-acylated ambroxol derivatives on secretion of chloride ions in human airway epithelia. | Biochemical and biophysical research communications 20090313 |
| Short-term perioperative treatment with ambroxol reduces pulmonary complications and hospital costs after pulmonary lobectomy: a randomized trial. | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20090301 |
| Unexpected infant deaths associated with use of cough and cold medications. | Pediatrics 20090201 |
| Photosensitivity with eosinophilia due to ambroxol and UVB. | Contact dermatitis 20090201 |
| [The cleaning system of the airways: physiology, pathophysiology and effects of ambroxol]. | Medizinische Monatsschrift fur Pharmazeuten 20090201 |
| Nebulized and oral thiol derivatives for pulmonary disease in cystic fibrosis. | The Cochrane database of systematic reviews 20090121 |
| Stability study of ambroxol hydrochloride sustained release pellets coated with acrylic polymer. | Pakistan journal of pharmaceutical sciences 20090101 |
| Ambroxol-induced systemic contact dermatitis confirmed by positive patch test. | Allergologia et immunopathologia 20090101 |
| Differential modulation of IgE-dependent activation of human basophils by ambroxol and related secretolytic analogues. | International journal of immunopathology and pharmacology 20090101 |
| Development and validation of a reversed-phase HPLC method for simultaneous estimation of ambroxol hydrochloride and azithromycin in tablet dosage form. | Journal of pharmaceutical and biomedical analysis 20081215 |
| Antiinflammatory properties of ambroxol. | European journal of medical research 20081203 |
| Protective effect of ambroxol on pulmonary function after cardiopulmonary bypass. | Journal of cardiovascular pharmacology 20081201 |
| Simultaneous determination of amoxicillin and ambroxol in human plasma by LC-MS/MS: validation and application to pharmacokinetic study. | Journal of pharmaceutical and biomedical analysis 20081104 |
| Rapid and sensitive liquid chromatography tandem mass spectrometry method for the quantification of ambroxol in human plasma. | Biomedical chromatography : BMC 20081001 |
| Influence of formulation and preparation process on ambroxol hydrochloride dry powder inhalation characteristics and aerosolization properties. | Drug development and industrial pharmacy 20080901 |
| HPLC and chemometrics-assisted UV-spectroscopy methods for the simultaneous determination of ambroxol and doxycycline in capsule. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080801 |
| [A study of the mechanism of Qingre Huatan therapy in treatment of acute exacerbation of chronic obstructive pulmonary disease by improving airway inflammation and mucus hypersecretion]. | Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20080801 |
| Ambroxol in the 21st century: pharmacological and clinical update. | Expert opinion on drug metabolism & toxicology 20080801 |
| Effects of ambroxol on alginate of mature Pseudomonas aeruginosa biofilms. | Current microbiology 20080701 |
| Flow injection analysis using carbon film resistor electrodes for amperometric determination of ambroxol. | Talanta 20080630 |
| Simultaneous determination of gatifloxacin and ambroxol hydrochloride from tablet dosage form using reversed-phase high performance liquid chromatography. | Se pu = Chinese journal of chromatography 20080501 |
| Upregulation of AQP3 and AQP5 induced by dexamethasone and ambroxol in A549 cells. | Respiratory physiology & neurobiology 20080430 |
| Simultaneous determination of multi drug components Theophylline, Etofylline, Guaiphenesine and Ambroxol Hydrochloride by validated RP-HPLC method in liquid dosage form. | Pakistan journal of pharmaceutical sciences 20080401 |
| Development of the ambroxol gels for enhanced transdermal delivery. | Drug development and industrial pharmacy 20080301 |
| Ambroxol: a CNS drug? | CNS neuroscience & therapeutics 20080101 |
| [The history of antitussive and expectorants]. | Pharmazie in unserer Zeit 20080101 |
| Efficacy and safety of ambroxol lozenges in the treatment of acute uncomplicated sore throat. EBM-based clinical documentation. | Arzneimittel-Forschung 20080101 |
| The potential role of natural agents in treatment of airway inflammation. | Therapeutic advances in respiratory disease 20071201 |
| [Effects of high dose ambroxol on lung injury induced by paraquat in rats]. | Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20070901 |
| [Effect of large volume lavage of ambroxol hydrochloride on patients with pneumoconiosis combined with chronic bronchitis]. | Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20070901 |
| Direct, non-destructive quantitative measurement of an active pharmaceutical ingredient in an intact capsule formulation using Raman spectroscopy. | Analytica chimica acta 20070829 |
| Simultaneous determination and pharmacokinetic study of roxithromycin and ambroxol hydrochloride in human plasma by LC-MS/MS. | Clinica chimica acta; international journal of clinical chemistry 20070701 |
| Spectrophotometric estimation of ambroxol and cetirizine hydrochloride from tablet dosage form. | Pakistan journal of pharmaceutical sciences 20070701 |
| Determination of ambroxol in human plasma by high performance liquid chromatography-electrospray ionization mass spectrometry (HPLC-MS/ESI). | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070615 |
| Acebrophylline: an airway mucoregulator and anti-inflammatory agent. | Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace 20070601 |
| Action of neltenexine on anion secretion in human airway epithelia. | Biochemical and biophysical research communications 20070518 |
| Solid-state chemistry of ambroxol theophylline-7-acetate. | Journal of pharmaceutical sciences 20070501 |
| Parenteral ambroxol treatment causes xanthine and calcium oxalate stones in rats. | International journal of urology : official journal of the Japanese Urological Association 20070501 |
| In situ gelling pectin formulations for oral drug delivery at high gastric pH. | International journal of pharmaceutics 20070420 |
| [Determination of ambroxol and clenbuterol in human plasma by LC-MS/MS method]. | Yao xue xue bao = Acta pharmaceutica Sinica 20070301 |
| Proteases essential for human influenza virus entry into cells and their inhibitors as potential therapeutic agents. | Current pharmaceutical design 20070101 |
| Uric acid plasma level and urine pH in rats treated with ambroxol. | Acta poloniae pharmaceutica 20070101 |
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| Safety and usage pattern of an over-the-counter ambroxol cough syrup: a community pharmacy-based cohort study. | International journal of clinical pharmacology and therapeutics 20060901 |
| [Efficacy of intravenous or atomizing ambroxol for prevention of respiratory distress syndrome in preterm infants]. | Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20060801 |
| [Atomization inhalation of ambroxol as an auxiliary therapy for severe pneumonia in neonates]. | Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20060601 |
| Ambroxol for the prevention of acute upper respiratory disease. | Clinical and experimental medicine 20060601 |
| [Influence of ambroxol on paraquat-induced lung tissue injury and change of pulmonary surfactant-associated protein A in the experimental rats]. | Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20060601 |
| Ambroxol-induced modification of ion transport in human airway Calu-3 epithelia. | Biochemical and biophysical research communications 20060505 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| The influence of variation of gastric pH on the gelation and release characteristics of in situ gelling pectin formulations. | International journal of pharmaceutics 20060407 |
| Comparison of the effects of four Na+ channel analgesics on TTX-resistant Na+ currents in rat sensory neurons and recombinant Nav1.2 channels. | Neuroscience letters 20060313 |
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| [Ambroxol-induced toxicoderma]. | Annales de dermatologie et de venereologie 20060201 |
| [Ambroxol]. | Tuberkuloz ve toraks 20060101 |
| Ambroxol, a Nav1.8-preferring Na(+) channel blocker, effectively suppresses pain symptoms in animal models of chronic, neuropathic and inflammatory pain. | Neuropharmacology 20051201 |
| [Treatment of sore throat pain with ambroxol-containing lozenges. Results of a pharmacy supported patient questionnaire]. | Medizinische Monatsschrift fur Pharmazeuten 20051101 |
| Determination of roxithromycin in rat lung tissue by liquid chromatography-mass spectrometry. | Journal of pharmaceutical and biomedical analysis 20050915 |
| Nondestructive determination of the ambroxol content in tablets by Raman spectroscopy. | Journal of pharmaceutical and biomedical analysis 20050615 |
| The effect of taste masking agents on in situ gelling pectin formulations for oral sustained delivery of paracetamol and ambroxol. | International journal of pharmaceutics 20050613 |
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| Determination of ambroxol in an automated multi-pumping pulsed flow system. | Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20050401 |
| Adsorptive stripping voltammetric determination of ambroxol. | Die Pharmazie 20050301 |
| Cell-specific modulation of surfactant proteins by ambroxol treatment. | Toxicology and applied pharmacology 20050215 |
| Effect of ambroxol, spirulina and vitamin-E in naphthalene induced cataract in female rats. | Indian journal of physiology and pharmacology 20050101 |
| The influence of ambroxol and capsaicin on the isolated rabbit bladder wall. | Acta poloniae pharmaceutica 20050101 |
| Oral ambroxol supplement in pregnant women induces fetal lung maturation. | American journal of obstetrics and gynecology 20041201 |
| In vitro and in vivo antioxidant activity of ambroxol. | Clinical and experimental medicine 20041201 |
| [Protective effects of ambroxol on lung injury during cardiacpulmonary bypass in patients undergoing valve replacement]. | Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20041201 |
| Secretory leukoprotease inhibitor and pulmonary surfactant serve as principal defenses against influenza A virus infection in the airway and chemical agents up-regulating their levels may have therapeutic potential. | Biological chemistry 20041101 |
| [Oxidative and anti-oxidative effects of ambroxol on acute hydrochloric acid-induced lung injury in rats]. | Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20041001 |
| Simultaneous determination of roxithromycin and ambroxol hydrochloride in a new tablet formulation by liquid chromatography. | Journal of pharmaceutical and biomedical analysis 20040903 |
| Ambroxol reduces LPS toxicity mediated by induction of alkaline phosphatases in rat lung. | Clinical biochemistry 20040801 |
| [Clinical observation on Biyan Qingdu Granule and ambroxol hydrochloride in treating secretory otitis media]. | Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20040701 |
| [Comparison of the effect of ambroxol and dexamethasone on the expression of pulmonary surfactant proteins in the fetal rat lungs]. | Zhonghua er ke za zhi = Chinese journal of pediatrics 20040601 |
| Oral sustained delivery of ambroxol from in situ-gelling pectin formulations. | International journal of pharmaceutics 20040301 |
| Inhibition of inflammatory responses by ambroxol, a mucolytic agent, in a murine model of acute lung injury induced by lipopolysaccharide. | Intensive care medicine 20040101 |
| Bioequivalence assessment of ambroxol tablet after a single oral dose administration to healthy male volunteers. | Pharmacological research 20040101 |
| Effect of twelve-months therapy with oral ambroxol in preventing exacerbations in patients with COPD. Double-blind, randomized, multicenter, placebo-controlled study (the AMETHIST Trial). | Pulmonary pharmacology & therapeutics 20040101 |
| [A near-infrared diffuse reflectance analysis method for the noninvasive quantitative analysis of ambroxol hydrochloride tablets]. | Yao xue xue bao = Acta pharmaceutica Sinica 20040101 |
| Inhibition of bleomycin-induced cell death in rat alveolar macrophages and human lung epithelial cells by ambroxol. | Biochemical pharmacology 20031001 |
| In vitro inhibition of human neutrophil histotoxicity by ambroxol: evidence for a multistep mechanism. | British journal of pharmacology 20031001 |
| Simultaneous high-throughput determination of clenbuterol, ambroxol and bromhexine in pharmaceutical formulations by HPLC with potentiometric detection. | Journal of pharmaceutical and biomedical analysis 20030808 |
| Determination of ambroxol hydrochloride in pure solutions and some of its pharmaceutical preparations under batch and FIA conditions. | Farmaco (Societa chimica italiana : 1989) 20030801 |
| Pharmacokinetic properties of single-dose loratadine and ambroxol alone and combined in tablet formulations in healthy men. | Clinical therapeutics 20030801 |
| Determination of ambroxol in human plasma using LC-MS/MS. | Journal of pharmaceutical and biomedical analysis 20030601 |
| Quantitative determination of ambroxol in tablets by derivative UV spectrophotometric method and HPLC. | Journal of pharmaceutical and biomedical analysis 20030401 |
| Depressant effects of ambroxol and erdosteine on cytokine synthesis, granule enzyme release, and free radical production in rat alveolar macrophages activated by lipopolysaccharide. | Pharmacology & toxicology 20030401 |
| [Efficacy of combined drug therapy using a macrolide antibiotic and an antihistamine for adult patients with chronic paranasal sinusitis]. | The Japanese journal of antibiotics 20030401 |
| Sonolytic debromination of ambroxol process wastewater. | Water research 20030201 |
| Development of treatment for pulmonary alveolar proteinosis. | Internal medicine (Tokyo, Japan) 20021201 |
| Pulmonary alveolar proteinosis successfully treated with ambroxol. | Internal medicine (Tokyo, Japan) 20021201 |
| Inhibition of tetrodotoxin (TTX)-resistant and TTX-sensitive neuronal Na(+) channels by the secretolytic ambroxol. | Molecular pharmacology 20020901 |
| Ambroxol inhibits peroxynitrite-induced damage of alpha1-antiproteinase and free radical production in activated phagocytic cells. | Pharmacology & toxicology 20020901 |
| Effect of ambroxol on ion transport -- a model study. | Medical science monitor : international medical journal of experimental and clinical research 20020601 |
| Ambroxol suppresses influenza-virus proliferation in the mouse airway by increasing antiviral factor levels. | The European respiratory journal 20020501 |
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| Depressant effect of ambroxol on stimulated functional responses and cell death in rat alveolar macrophages exposed to silica in vitro. | The Journal of pharmacology and experimental therapeutics 20020201 |
| Ambroxol inhibits platelet-derived growth factor production in human monocytic cells. | European journal of pharmacology 20020201 |
| Local anaesthetic properties of ambroxol hydrochloride lozenges in view of sore throat. Clinical proof of concept. | Arzneimittel-Forschung 20020101 |
| Efficacy and tolerability of ambroxol hydrochloride lozenges in sore throat. Randomised, double-blind, placebo-controlled trials regarding the local anaesthetic properties. | Arzneimittel-Forschung 20020101 |
| [Effect of ambroxol on lipid peroxidation in homogenates of the human placenta]. | Ginekologia polska 20011001 |
| Enhanced resistance to Sendai virus infection in DBA/2J mice with a botanical drug combination (Sinupret). | International immunopharmacology 20010901 |
| [The effect of inhaled ambroxol treatment on clinical symptoms and chosen parameters of ventilation in patients with exacerbation of chronic obstructive pulmonary disease patients]. | Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20010901 |
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| Neltenexine tablets in smoking and non-smoking patients with COPD. A double-blind, randomised, controlled study versus placebo. | Minerva medica 20010801 |
| Attenuation by ambroxol of monochloramine-enhanced gastric carcinogenesis: a possible prevention against Helicobacter pylori-associated gastric carcinogenesis. | Cancer letters 20010726 |
| Preventing exacerbations of chronic bronchitis and COPD. | BMJ (Clinical research ed.) 20010526 |
| Validation of an HPLC method for the quantification of ambroxol hydrochloride and benzoic acid in a syrup as pharmaceutical form stress test for stability evaluation. | Journal of pharmaceutical and biomedical analysis 20010301 |
| Modulating effects of mucoregulating drugs on the attachment of Haemophilus influenzae. | Microbial pathogenesis 20010301 |
| The effect of serotonin on airway transepithelial sodium ion pathways. | European journal of pharmacology 20010126 |
| Determination of ambroxol or bromhexine in pharmaceuticals by capillary isotachophoresis. | Journal of pharmaceutical and biomedical analysis 20010101 |
| [Effects of carbocisteine on airway inflammation and related events in SO2-exposed rats]. | Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20010101 |
| [Effectiveness of lasolvan in patients with chronic obstructive bronchitis and non-atopic bronchial asthma]. | Terapevticheskii arkhiv 20010101 |
| [Antioxidative features of ambroxol--usefulness in COPD]. | Pneumonologia i alergologia polska 20010101 |
| The effect of a single oral administration of ambroxol on the ultrastructure of the epithelium of terminal bronchioles in rabbits. | Sbornik lekarsky 20010101 |
| Effects of a short course of treatment with acebrophylline on the mucus rheological characteristics and respiratory function parameters in patients suffering from chronic obstructive pulmonary disease. | The Journal of international medical research 19960101 |
| Activity of bromhexine and ambroxol, semi-synthetic derivatives of vasicine from the Indian shrub Adhatoda vasica, against Mycobacterium tuberculosis in vitro. | Journal of ethnopharmacology 19960101 |
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