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1144-20-3 | 4-Quinolinol, 2-phenyl-
CAS No: 1144-20-3 Catalog No: AG000B8R MDL No:MFCD00160565
Product Description
Catalog Number:
AG000B8R
Chemical Name:
4-Quinolinol, 2-phenyl-
CAS Number:
1144-20-3
Molecular Formula:
C15H11NO
Molecular Weight:
221.2539
MDL Number:
MFCD00160565
IUPAC Name:
2-phenyl-1H-quinolin-4-one
InChI:
InChI=1S/C15H11NO/c17-15-10-14(11-6-2-1-3-7-11)16-13-9-5-4-8-12(13)15/h1-10H,(H,16,17)
InChI Key:
JGABMVVOXLQCKZ-UHFFFAOYSA-N
SMILES:
Oc1cc(nc2c1cccc2)c1ccccc1
NSC Number:
28866
Properties
Complexity:
328
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
221.084g/mol
Formal Charge:
0
Heavy Atom Count:
17
Hydrogen Bond Acceptor Count:
2
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
221.259g/mol
Monoisotopic Mass:
221.084g/mol
Rotatable Bond Count:
1
Topological Polar Surface Area:
29.1A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.2
Literature
| Title | Journal |
|---|---|
| CWF-145, a novel synthetic quinolone derivative exerts potent antimitotic activity against human prostate cancer: Rapamycin enhances antimitotic drug-induced apoptosis through the inhibition of Akt/mTOR pathway. | Chemico-biological interactions 20161225 |
| Evaluation of synthetic acridones and 4-quinolinones as potent inhibitors of cathepsins L and V. | European journal of medicinal chemistry 20120801 |
| Antioxidant properties of 4-quinolones and structurally related flavones. | Bioorganic & medicinal chemistry 20120115 |
| KHC-4 anti-cancer effects on human PC3 prostate cancer cell line. | The American journal of Chinese medicine 20120101 |
| Evolution from a natural flavones nucleus to obtain 2-(4-Propoxyphenyl)quinoline derivatives as potent inhibitors of the S. aureus NorA efflux pump. | Journal of medicinal chemistry 20110825 |
| Non-covalent inhibitors of rhinovirus 3C protease. | Bioorganic & medicinal chemistry letters 20110115 |
| Specific microtubule-depolymerizing agents augment efficacy of dendritic cell-based cancer vaccines. | Journal of biomedical science 20110101 |
| Novel quinolone CHM-1 induces apoptosis and inhibits metastasis in a human osterogenic sarcoma cell line. | Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20091201 |
| Induction of mitotic arrest and apoptosis by a novel synthetic quinolone analogue, CWC-8, via intrinsic and extrinsic apoptotic pathways in human osteogenic sarcoma U-2 OS cells. | Anticancer research 20090801 |
| Selective targeting of tumorigenic cancer cell lines by microtubule inhibitors. | PloS one 20090101 |
| CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo. | Molecular cancer therapeutics 20080201 |
| CHM-1 inhibits hepatocyte growth factor-induced invasion of SK-Hep-1 human hepatocellular carcinoma cells by suppressing matrix metalloproteinase-9 expression. | Cancer letters 20071108 |
| Quinolone analogue inhibits tubulin polymerization and induces apoptosis via Cdk1-involved signaling pathways. | Biochemical pharmacology 20070630 |
| 2-(3-Fluorophenyl)-6-methoxyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (YJC-1) induces mitotic phase arrest in A549 cells. | European journal of pharmacology 20070315 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Cancer preventive agents, Part 2: Synthesis and evaluation of 2-phenyl-4-quinolone and 9-oxo-9,10-dihydroacridine derivatives as novel antitumor promoters. | Bioorganic & medicinal chemistry 20050715 |
| Synthesis and biological relationships of 3',6-substituted 2-phenyl-4-quinolone-3-carboxylic acid derivatives as antimitotic agents. | Bioorganic & medicinal chemistry 20050103 |
| Antitumor Agents. 211. Fluorinated 2-phenyl-4-quinolone derivatives as antimitotic antitumor agents. | Journal of medicinal chemistry 20011108 |
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