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112811-59-3 | 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-
CAS No: 112811-59-3 Catalog No: AG001VAA MDL No:MFCD00895399
Product Description
Catalog Number:
AG001VAA
Chemical Name:
3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-
CAS Number:
112811-59-3
Molecular Formula:
C19H22FN3O4
Molecular Weight:
375.3941
MDL Number:
MFCD00895399
IUPAC Name:
1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
InChI:
InChI=1S/C19H22FN3O4/c1-10-8-22(6-5-21-10)16-14(20)7-12-15(18(16)27-2)23(11-3-4-11)9-13(17(12)24)19(25)26/h7,9-11,21H,3-6,8H2,1-2H3,(H,25,26)
InChI Key:
XUBOMFCQGDBHNK-UHFFFAOYSA-N
SMILES:
COc1c(N2CCNC(C2)C)c(F)cc2c1n(cc(c2=O)C(=O)O)C1CC1
NSC Number:
758701
Properties
Complexity:
653
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
375.159g/mol
Formal Charge:
0
Heavy Atom Count:
27
Hydrogen Bond Acceptor Count:
8
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
375.4g/mol
Monoisotopic Mass:
375.159g/mol
Rotatable Bond Count:
4
Topological Polar Surface Area:
82.1A^2
Undefined Atom Stereocenter Count:
1
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.7
Literature
| Title | Journal |
|---|---|
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| Simultaneous determination of ofloxacin and gatifloxacin on cysteic acid modified electrode in the presence of sodium dodecyl benzene sulfonate. | Bioelectrochemistry (Amsterdam, Netherlands) 20130201 |
| Combined contributions of over-secreted glucagon-like peptide 1 and suppressed insulin secretion to hyperglycemia induced by gatifloxacin in rats. | Toxicology and applied pharmacology 20130201 |
| Transporter targeted gatifloxacin prodrugs: synthesis, permeability, and topical ocular delivery. | Molecular pharmaceutics 20121105 |
| Aluminium sensitized spectrofluorimetric determination of fluoroquinolones in milk samples coupled with salting-out assisted liquid-liquid ultrasonic extraction. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20121001 |
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| Efficacy of gemifloxacin for the treatment of experimental Staphylococcus aureus keratitis. | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20120801 |
| Molecularly imprinted stationary phase prepared by reverse micro-emulsion polymerization for selective recognition of gatifloxacin in aqueous media. | Journal of chromatographic science 20120701 |
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| Identification of pharmacophore in bioactive metal complexes: Synthesis, spectroscopic characterization and application. | European journal of medicinal chemistry 20120401 |
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| Development of an electrochemical immunoassay for detection of gatifloxacin in swine urine. | Journal of Zhejiang University. Science. B 20120201 |
| Achromobacter xylosoxidans keratitis after contact lens usage. | Korean journal of ophthalmology : KJO 20120201 |
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| Ophthalmic antibiotic use and multidrug-resistant staphylococcus epidermidis: a controlled, longitudinal study. | Ophthalmology 20111001 |
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| Synthesis and in vitro antibacterial activity of a series of novel gatifloxacin derivatives. | European journal of medicinal chemistry 20110901 |
| Effect of gatifloxacin against Mycoplasma genitalium-related urethritis: an open clinical trial. | Sexually transmitted infections 20110801 |
| A multi-center randomized trial to assess the efficacy of gatifloxacin versus ciprofloxacin for the treatment of shigellosis in Vietnamese children. | PLoS neglected tropical diseases 20110801 |
| Ultrasensitive study of gatifloxacin based on its enhancing effect on the cerium (IV)-sodium hyposulfite chemiluminescence reaction in a micellar medium. | Journal of fluorescence 20110701 |
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| Outpatient treatment of patients with enteric fever. | The Lancet. Infectious diseases 20110601 |
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| Human aqueous humor concentrations of besifloxacin, moxifloxacin, and gatifloxacin after topical ocular application. | Journal of cataract and refractive surgery 20110601 |
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| Comparison of besifloxacin, gatifloxacin, and moxifloxacin against strains of pseudomonas aeruginosa with different quinolone susceptibility patterns in a rabbit model of keratitis. | Cornea 20110101 |
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| Docking studies on novel analogues of 8 methoxy fluoroquinolones against GyrA mutants of Mycobacterium tuberculosis. | BMC structural biology 20110101 |
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| Nanosized dendritic polyguanidilyated translocators for enhanced solubility, permeability, and delivery of gatifloxacin. | Investigative ophthalmology & visual science 20101101 |
| Comparison of the effects of fourth-generation fluoroquinolones on epithelial healing after photorefractive keratectomy. | Cornea 20101101 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| Gatifloxacin-induced histamine release and hyperglycemia in rats. | European journal of pharmacology 20101025 |
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| An adaptable HPLC method for the analysis of frequently used antibiotics in ocular samples. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100915 |
| Determination of gatifloxacin in pure form and pharmaceutical formulations by differential pulse polarographic analysis. | Analytical biochemistry 20100901 |
| Comparison of the influence of intracameral gentamicin, gatifloxacin, and moxifloxacin on the corneal endothelium in a rabbit model. | Japanese journal of ophthalmology 20100901 |
| Interaction of gatifloxacin with efflux transporters: a possible mechanism for drug resistance. | International journal of pharmaceutics 20100816 |
| Simultaneous determination of isoniazid, rifampicin, levofloxacin in mouse tissues and plasma by high performance liquid chromatography-tandem mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100815 |
| Determination of drug concentration in aqueous humor of cataract patients administered gatifloxacin ophthalmic gel. | Chinese medical journal 20100805 |
| In vitro antituberculosis activities of ACH-702, a novel isothiazoloquinolone, against quinolone-susceptible and quinolone-resistant isolates. | Antimicrobial agents and chemotherapy 20100801 |
| Electrochemical determination of gatifloxacin, moxifloxacin and sparfloxacin fluoroquinolonic antibiotics on glassy carbon electrode in pharmaceutical formulations. | Drug testing and analysis 20100801 |
| Randomized clinical study for comparative evaluation of fourth-generation fluoroquinolones with the combination of fortified antibiotics in the treatment of bacterial corneal ulcers. | Cornea 20100701 |
| Antimicrobial susceptibility testing of newer quinolones against gram positive and gram negative clinical isolates. | Pakistan journal of pharmaceutical sciences 20100701 |
| In vitro activities of DC-159a, a novel fluoroquinolone, against Mycobacterium species. | Antimicrobial agents and chemotherapy 20100601 |
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| Effect of fluoroquinolones on body temperature of mice. | The Journal of antimicrobial chemotherapy 20081201 |
| Synergy of gatifloxacin with cefoperazone and cefoperazone-sulbactam against resistant strains of Pseudomonas aeruginosa. | Journal of medical microbiology 20081201 |
| Determination of the inhibitory potential of 6 fluoroquinolones on CYP1A2 and CYP2C9 in human liver microsomes. | Acta pharmacologica Sinica 20081201 |
| A comparison of fluoroquinolone penetration into human conjunctival tissue. | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20081201 |
| Gatifloxacin-based triple therapy as a third-line regimen for Helicobacter pylori eradication. | Journal of gastroenterology and hepatology 20081201 |
| Linking bisphosphonates to the free amino groups in fluoroquinolones: preparation of osteotropic prodrugs for the prevention of osteomyelitis. | Journal of medicinal chemistry 20081113 |
| Development and validation of a HPLC method for simultaneous quantitation of gatifloxacin, sparfloxacin and moxifloxacin using levofloxacin as internal standard in human plasma: application to a clinical pharmacokinetic study. | Biomedical chromatography : BMC 20081101 |
| Comparison of one-day versus one-hour application of topical gatifloxacin in eliminating conjunctival bacterial flora. | Ophthalmology 20081101 |
| Pasteurized whole milk confers reduced susceptibilities to the antimicrobial agents trimethoprim, gatifloxacin, cefotaxime and tetracycline via the marRAB locus in Escherichia coli. | The Journal of dairy research 20081101 |
| The inhibition of gluconeogenesis by gatifloxacin may contribute to its hypoglycaemic action. | European journal of pharmacology 20081010 |
| An evaluation of the effects of gatifloxacin on glucose homeostasis. | Pharmacy world & science : PWS 20081001 |
| Comparison of the effects of fourth-generation fluoroquinolones on corneal re-epithelialization in rabbit eyes. | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20081001 |
| Successful treatment of post-neurosurgical intracranial Mycoplasma hominis infection using gatifloxacin. | The Journal of infection 20081001 |
| Antimicrobial activity of acrylic intraocular lenses soaked in fourth generation fluoroquinolones. | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20081001 |
| Laboratory data and statistical evidence in fluoroquinolone study. | Journal of cataract and refractive surgery 20081001 |
| Review of third-and fourth-generation fluoroquinolones in ophthalmology: in-vitro and in-vivo efficacy. | Advances in therapy 20081001 |
| Preventive effect against post-cataract endophthalmitis: drug delivery intraocular lens versus intracameral antibiotics. | Current eye research 20081001 |
| Third- and fourth-generation fluoroquinolones: retrospective comparison of endophthalmitis after cataract surgery performed over 10 years. | Journal of cataract and refractive surgery 20080901 |
| Evaluation of toxicity of commercial ophthalmic fluoroquinolone antibiotics as assessed on immortalized corneal and conjunctival epithelial cells. | Cornea 20080901 |
| Biofilm formation is not necessary for development of quinolone-resistant 'persister' cells in an attached Staphylococcus epidermidis population. | The International journal of artificial organs 20080901 |
| grlA and gyrA mutations and antimicrobial susceptibility in clinical isolates of ciprofloxacin- methicillin-resistant Staphylococcus aureus. | European journal of medical research 20080818 |
| Benzalkonium chloride enhances the antibacterial efficacy of gatifloxacin in an experimental rabbit model of intrastromal keratitis. | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20080801 |
| Evaluation of clinical dosage of gatifloxacin for respiratory tract infections in elderly patients based on pharmacokinetics/pharmacodynamics (PK/PD). | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20080801 |
| Haemoptysis associated with gatifloxacin in a 27 year old male asthmatic--a case report. | British journal of clinical pharmacology 20080701 |
| Evaluation of gatifloxacin penetration into skeletal muscle and lung by microdialysis in rats. | International journal of pharmaceutics 20080624 |
| Mutations in the quinolone resistance determining region in Staphylococcus epidermidis recovered from conjunctiva and their association with susceptibility to various fluoroquinolones. | The British journal of ophthalmology 20080601 |
| Prophylactic efficacy of ophthalmic quinolones in experimental endophthalmitis in rabbits. | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20080601 |
| [Resistance profiles to fluoroquinolones in clinical isolates of Gram positive cocci]. | Biomedica : revista del Instituto Nacional de Salud 20080601 |
| Aqueous humor penetration of gatifloxacin and moxifloxacin eyedrops given in different concentrations in a wick before cataract surgery. | Journal of cataract and refractive surgery 20080501 |
| Prevention of endophthalmitis by collagen shields presoaked in fourth-generation fluoroquinolones versus by topical prophylaxis. | Journal of cataract and refractive surgery 20080501 |
| The effect of cyclosporine A (Restasis) on recovery of visual acuity following LASIK. | Journal of refractive surgery (Thorofare, N.J. : 1995) 20080501 |
| Simultaneous determination of gatifloxacin and ambroxol hydrochloride from tablet dosage form using reversed-phase high performance liquid chromatography. | Se pu = Chinese journal of chromatography 20080501 |
| Cerebral vacuolation induced in rats by the administration of LUP-3FDC, an anti-tuberculosis cocktail. | Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20080401 |
| Antimycobacterial and phototoxic evaluation of novel 6-fluoro/nitro-4-oxo-7-(sub)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid. | International journal of antimicrobial agents 20080401 |
| Ocular penetration and pharmacokinetics of topical gatifloxacin 0.3% and moxifloxacin 0.5% ophthalmic solutions after keratoplasty. | Cornea 20080401 |
| Corneal perforation associated with topically applied gatifloxacin. | Cornea 20080401 |
| Radiation recall dermatitis with gatifloxacin: a review of literature. | Journal of medical imaging and radiation oncology 20080401 |
| Toward improving therapeutic regimens for Bacillus endophthalmitis. | Investigative ophthalmology & visual science 20080401 |
| Levofloxacin and hypoglycemia. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20080401 |
| In vitro evaluation of the antimicrobial activity of meropenem in combination with polymyxin B and gatifloxacin against Pseudomonas aeruginosa and Acinetobacter baumannii. | Journal of chemotherapy (Florence, Italy) 20080401 |
| Gatifloxacin treatment for chronic prostatitis: a prospective multicenter clinical trial. | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20080401 |
| Antimycobacterial activities of novel 2-(sub)-3-fluoro/nitro-5,12-dihydro-5-oxobenzothiazolo[3,2-a]quinoline-6-carboxylic acid. | Bioorganic & medicinal chemistry 20080315 |
| Information about a discontinued drug. | CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20080311 |
| The inhibitory effects of fluoroquinolones on L-carnitine transport in placental cell line BeWo. | International journal of pharmaceutics 20080303 |
| Chitosan-sodium alginate nanoparticles as submicroscopic reservoirs for ocular delivery: formulation, optimisation and in vitro characterisation. | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20080301 |
| Synthesis and antimycobacterial evaluation of newer 1-cyclopropyl-1,4-dihydro-6-fluoro-7-(substituted secondary amino)-8-methoxy-5-(sub)-4-oxoquinoline-3-carboxylic acids. | Bioorganic & medicinal chemistry 20080301 |
| In vitro susceptibilities of bacterial isolates from conjunctival flora to gatifloxacin, levofloxacin, tosufloxacin, and moxifloxacin. | Eye & contact lens 20080301 |
| Gatifloxacin. | Tuberculosis (Edinburgh, Scotland) 20080301 |
| [Analysis on susceptibility of ocular bacterial pathogens to four kinds of fluoroquinolone]. | [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20080301 |
| Anxiogenic and proconvulsant effect of gatifloxacin in mice. | European journal of pharmacology 20080202 |
| Fluorescence probe enhanced spectrofluorimetric method for the determination of gatifloxacin in pharmaceutical formulations and biological fluids. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080201 |
| Novel ofloxacin derivatives: synthesis, antimycobacterial and toxicological evaluation. | Bioorganic & medicinal chemistry letters 20080201 |
| Intrinsic cytotoxic effects of fluoroquinolones on human corneal keratocytes and endothelial cells. | Current medical research and opinion 20080201 |
| A Phase II study of the sterilising activities of ofloxacin, gatifloxacin and moxifloxacin in pulmonary tuberculosis. | The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 20080201 |
| Fluoroquinolone therapy in a rabbit model of post-LASIK methicillin-resistant Staphylococcus aureus keratitis. | Journal of cataract and refractive surgery 20080201 |
| Endophthalmitis. | Ophthalmology 20080201 |
| Gatifloxacin produces both hypoglycemia and hyperglycemia: a retrospective study. | The American journal of the medical sciences 20080201 |
| Antimicrobial effect of fluoroquinolones for the eradication of nontypeable Haemophilus influenzae isolates within biofilms. | The Tohoku journal of experimental medicine 20080201 |
| Antibiotic-loaded poly-epsilon-caprolactone and porous beta-tricalcium phosphate composite for treating osteomyelitis. | Biomaterials 20080101 |
| Prevalence of and risk factors for dysglycemia in patients receiving gatifloxacin and levofloxacin in an outpatient setting. | Pharmacotherapy 20080101 |
| Rapid determination of gatifloxacin in biological samples and pharmaceutical products using europium-sensitized fluorescence spectrophotometry. | Luminescence : the journal of biological and chemical luminescence 20080101 |
| Utility of some pi-acceptors for spectrophotometric determination of gatifloxacin in pure form and in pharmaceutical preparations. | Chemical & pharmaceutical bulletin 20080101 |
| Antimicrobial efficacy of prophylactic gatifloxacin 0.3% and moxifloxacin 0.5% in patients undergoing phacoemulsification surgery. | Eye & contact lens 20080101 |
| Immunomodulatory effect of gatifloxacin on mouse peritoneal macrophages in vitro and in models of endotoxin-induced rat conjunctivitis and rabbit bacterial keratitis. | Ophthalmic research 20080101 |
| Evaluation of Clostridium difficile-associated diarrhea with a drug formulary change in preferred fluoroquinolones. | Journal of managed care pharmacy : JMCP 20080101 |
| [A case of multi-drug resistant tuberculosis showing psychiatric adverse effect by cycloserine]. | Kekkaku : [Tuberculosis] 20080101 |
| Risk factors for hyperglycemia in hospitalized adults receiving gatifloxacin: a retrospective, nested case-controlled analysis. | Clinical therapeutics 20080101 |
| A multi-center randomised controlled trial of gatifloxacin versus azithromycin for the treatment of uncomplicated typhoid fever in children and adults in Vietnam. | PloS one 20080101 |
| [Conjunctival bacterial flora after topical use of ciprofloxacin and gatifloxacin in cataract surgery]. | Arquivos brasileiros de oftalmologia 20080101 |
| Gatifloxacin-induced rhabdomyolysis. | Journal of postgraduate medicine 20080101 |
| A case of Vibrio vulnificus keratitis. | Japanese journal of ophthalmology 20080101 |
| The effects of moxifloxacin ophthalmic solution 0.5% or gatifloxacin ophthalmic solution 0.3% treatment on corneal wound healing in pigmented rabbits following anterior keratectomy. | Veterinary ophthalmology 20080101 |
| An atom efficient, solvent-free, green synthesis and antimycobacterial evaluation of 2-amino-6-methyl-4-aryl-8-[(E)-arylmethylidene]-5,6,7,8-tetrahydro-4H-pyrano[3,2-c]pyridine-3-carbonitriles. | Bioorganic & medicinal chemistry letters 20071201 |
| The ocular penetration of levofloxacin 1.5% and gatifloxacin 0.3% ophthalmic solutions in subjects undergoing corneal transplant surgery. | Current medical research and opinion 20071201 |
| Elevated gatifloxacin and reduced rifampicin concentrations in a single-dose interaction study amongst healthy volunteers. | The Journal of antimicrobial chemotherapy 20071201 |
| Corneal wound healing in New Zealand White Rabbits following anterior keratectomy and treatment with moxifloxacin ophthalmic solution 0.5% or gatifloxacin ophthalmic solution 0.3%. | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20071201 |
| Study on the ocular pharmacokinetics of ion-activated in situ gelling ophthalmic delivery system for gatifloxacin by microdialysis. | Drug development and industrial pharmacy 20071201 |
| Antimycobacterial activities of novel 1-(cyclopropyl/tert-butyl/4-fluorophenyl)-1,4-dihydro- 6-nitro-4-oxo-7-(substituted secondary amino)-1,8-naphthyridine-3-carboxylic acid. | Journal of medicinal chemistry 20071129 |
| The effect of publication on Internet-based solicitation of personal-injury litigants. | CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20071120 |
| Gatifloxacin affects GLUT1 gene expression and disturbs glucose homeostasis in vitro. | European journal of pharmacology 20071114 |
| Effects of gatifloxacin and levofloxacin on rates of hypoglycemia and hyperglycemia among elderly hospitalized patients. | Pharmacotherapy 20071101 |
| The increasing problem of antibiotic resistance. | Journal of cataract and refractive surgery 20071101 |
| Fourth-generation fluoroquinolone-resistant mycobacterial keratitis after laser in situ keratomileusis. | Journal of cataract and refractive surgery 20071101 |
| Gatifloxacin-associated hypoglycemia. | The Journal of the Oklahoma State Medical Association 20071101 |
| [Determination of the binding constant of bovine serum albumin and gatifloxacin using affinity capillary electrophoresis]. | Se pu = Chinese journal of chromatography 20071101 |
| Oral gatifloxacin in the outpatient treatment of children with cancer fever and neutropenia. | Pediatric blood & cancer 20071015 |
| Synthesis and antitubercular activity of lipophilic moxifloxacin and gatifloxacin derivatives. | Bioorganic & medicinal chemistry letters 20071015 |
| Topical ophthalmic fourth-generation fluoroquinolones: Appropriate use and cost considerations. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20071001 |
| [The proper use of quinolones to the elderly patient with community-acquired pneumonia examined by Monte Carlo simulation]. | The Japanese journal of antibiotics 20071001 |
| The risk of endophthalmitis following intravitreal triamcinolone injection in the DRCRnet and SCORE clinical trials. | American journal of ophthalmology 20070901 |
| Pharmacokinetics and pharmacodynamics of gatifloxacin in children with recurrent otitis media: application of sparse sampling in clinical development. | Diagnostic microbiology and infectious disease 20070901 |
| Preparation of anti-gatifloxacin antibody and development of an indirect competitive enzyme-linked immunosorbent assay for the detection of gatifloxacin residue in milk. | Journal of agricultural and food chemistry 20070822 |
| Spectrophotometric determination of gatifloxacin in pure form and in pharmaceutical formulation. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20070801 |
| Gatifloxacin in combination with rifampicin in a murine tuberculosis model. | The Journal of antimicrobial chemotherapy 20070801 |
| Gatifloxacin biodegradable implant for treatment of experimental osteomyelitis: in vitro and in vivo evaluation. | Drug delivery 20070801 |
| Antipneumococcal activity of ertapenem compared with gatifloxacin in a temperature-sensitive murine model of acute pneumonia. | Journal of chemotherapy (Florence, Italy) 20070801 |
| Atypical mycobacteria keratitis after laser in situ keratomileusis unresponsive to fourth-generation fluoroquinolone therapy. | Journal of cataract and refractive surgery 20070701 |
| Long-term prognostic value of neopterin: a novel marker of monocyte activation in patients with acute coronary syndrome. | Circulation 20070619 |
| Evaluation of gatifloxacin pharmacokinetics and pharmacodynamics in severely ill adults in a medical Intensive Care Unit. | International journal of antimicrobial agents 20070601 |
| Zymar (Gatifloxacin 0.3%) shows excellent Gram-negative activity against Serratia marcescens and Pseudomonas aeruginosa in a New Zealand White rabbit keratitis model. | Cornea 20070601 |
| Effect of fourth-generation fluoroquinolones on the healing rate of corneal erosions in an animal model. | Cornea 20070601 |
| High performance liquid chromatography for quantification of gatifloxacin in rat plasma following automated on-line solid phase extraction. | Journal of pharmaceutical and biomedical analysis 20070509 |
| In vitro efficacy and pharmacodynamic indices for antibiotics against coagulase-negative staphylococcus endophthalmitis isolates. | Ophthalmology 20070501 |
| In vitro activity of ciprofloxacin, ofloxacin, levofloxacin, sparfloxacin and gatifloxacin against multidrug-resistant Mycobacterium tuberculosis in Rio de Janeiro Brazil. | Medecine et maladies infectieuses 20070501 |
| Prophylactic gatifloxacin therapy in prevention of bacterial keratitis in a rabbit laser in situ keratomileusis model. | Journal of cataract and refractive surgery 20070501 |
| Comparative minimal inhibitory and mutant prevention drug concentrations of four fluoroquinolones against ocular isolates of Haemophilus influenzae. | Eye & contact lens 20070501 |
| Interaction characteristics and thermodynamic behaviour of gatifloxacin by aluminium hydroxide. | Drug development and industrial pharmacy 20070501 |
| Endophthalmitis after uncomplicated cataract surgery with the use of fourth-generation fluoroquinolones: a retrospective observational case series. | Ophthalmology 20070401 |
| Synthesis and antibacterial activity of 4,5,6,7-tetrahydro-thieno[3,2-c]pyridine quinolones. | Bioorganic & medicinal chemistry letters 20070401 |
| Gatifloxacin induces augmented insulin release and intracellular insulin depletion of pancreatic islet cells. | Biological & pharmaceutical bulletin 20070401 |
| Antimicrobial efficacy of gatifloxacin and moxifloxacin with and without benzalkonium chloride compared with ciprofloxacin and levofloxacin against methicillin-resistant Staphylococcus aureus. | Journal of chemotherapy (Florence, Italy) 20070401 |
| The effect of moxifloxacin and gatifloxacin on long-term visual outcomes following photorefractive keratectomy. | Journal of refractive surgery (Thorofare, N.J. : 1995) 20070401 |
| Development and validation of an ion-pairing RP-HPLC method for the estimation of gatifloxacin in bulk and formulations. | Journal of chromatographic science 20070401 |
| Fluoroquinolone resistance in Salmonella typhi and S. paratyphi A in Bangalore, India. | Transactions of the Royal Society of Tropical Medicine and Hygiene 20070301 |
| Influence of ethanol water-content on gatifloxacin recrystallisations. | Die Pharmazie 20070301 |
| Advancing age and renal impairment as important predisposing factors of gatifloxacin-induced hyperglycemia in non-diabetes patients. | Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20070301 |
| Synthesis and antibacterial activities of new quinolone derivatives utilizing 1-azabicyclo[1.1.0]butane. | Bioorganic & medicinal chemistry letters 20070215 |
| In vitro activity of fluoroquinolones against ocular bacterial isolates in São Paulo, Brazil. | Cornea 20070201 |
| Selection of a gyrA mutation and treatment failure with gatifloxacin in a patient with Streptococcus pneumoniae with a preexisting parC mutation. | Pharmacotherapy 20070201 |
| Dysglycemia and fluoroquinolones: are you putting patients at risk? | The Journal of family practice 20070201 |
| [In-vitro and in-vivo activities of moxifloxacin and garenoxacin against Mycobacterium leprae]. | Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association 20070201 |
| Collagen shields as a drug delivery system for the fourth-generation fluoroquinolones. | Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20070101 |
| Aqueous humor penetration of gatifloxacin and moxifloxacin eyedrops given by different methods before cataract surgery. | Journal of cataract and refractive surgery 20070101 |
| Exacerbation of psychotic symptoms associated with gatifloxacin. | Psychosomatics 20070101 |
| Antacid interaction with new quinolones: dose regimen recommendations based on pharmacokinetic modeling of clinical data for ciprofloxacin, gatifloxacin and norfloxacin and metal cations. | International journal of clinical pharmacology and therapeutics 20070101 |
| [Status epilepticus and gatifloxacin]. | Revue neurologique 20070101 |
| Pharmacokinetics of gatifloxacin after a single oral dose in healthy young adult subjects and adult patients with chronic bronchitis, with a comparison of drug concentrations obtained by bronchoscopic microsampling and bronchoalveolar lavage. | Clinical therapeutics 20070101 |
| Fluoroquinolone susceptibilities to methicillin-resistant and susceptible coagulase-negative Staphylococcus isolated from eye infection. | Arquivos brasileiros de oftalmologia 20070101 |
| An open randomized comparison of gatifloxacin versus cefixime for the treatment of uncomplicated enteric fever. | PloS one 20070101 |
| Penetration of gatifloxacin eye drops into the aqueous humor in humans. | Ocular immunology and inflammation 20070101 |
| [Cost-effectiveness of the treatment of acute and chronic rhinosinusitis at the IMSS]. | Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion 20070101 |
| In vitro study of staphylococci susceptibility to gatifloxacin. | Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20070101 |
| Endophthalmitis caused by staphylococcus epidermidis: in vitro antibiotic susceptibilities and clinical outcomes. | Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye 20070101 |
| [In vitro activity of ertapenem against staphylococci]. | Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20070101 |
| Gatifloxacin acutely stimulates insulin secretion and chronically suppresses insulin biosynthesis. | European journal of pharmacology 20061228 |
| Design, synthesis and activity against Toxoplasma gondii, Plasmodium spp., and Mycobacterium tuberculosis of new 6-fluoroquinolones. | European journal of medicinal chemistry 20061201 |
| High-level resistance to moxifloxacin and gatifloxacin associated with a novel mutation in gyrB in toxin-A-negative, toxin-B-positive Clostridium difficile. | The Journal of antimicrobial chemotherapy 20061201 |
| In vitro development of resistance to DX-619 and other quinolones in enterococci. | The Journal of antimicrobial chemotherapy 20061201 |
| Evaluation of the penetration of fluoroquinolones in human conjunctival tissue. | Archives of ophthalmology (Chicago, Ill. : 1960) 20061201 |
| In vitro antifungal activity of the fourth generation fluoroquinolones against Candida isolates from human ocular infections. | Ocular immunology and inflammation 20061201 |
| Biofilm formation on hydrophilic intraocular lens material. | Current eye research 20061201 |
| [Study investigating the activity of several fluoroquinolones against Pseudomonas aeruginosa using the mutant prevention concentration]. | Enfermedades infecciosas y microbiologia clinica 20061201 |
| Moxifloxacin and gatifloxacin in an acid model of persistent Mycobacterium tuberculosis. | Journal of chemotherapy (Florence, Italy) 20061201 |
| The first steps towards fluoroquinolone resistance in Hungarian pneumococci. | Journal of chemotherapy (Florence, Italy) 20061201 |
| Gatifloxacin induced abnormalities in glucose homeostasis in a patient on glimepiride. | The Journal of the Association of Physicians of India 20061201 |
| Gatifloxacin-induced severe hypoglycemia in a patient with type 2 diabetes mellitus. | The Journal of the Association of Physicians of India 20061201 |
| 3-aminoquinazolinediones as a new class of antibacterial agents demonstrating excellent antibacterial activity against wild-type and multidrug resistant organisms. | Journal of medicinal chemistry 20061102 |
| The in vitro impact of moxifloxacin and gatifloxacin concentration (0.5% vs 0.3%) and the addition of benzalkonium chloride on antibacterial efficacy. | American journal of ophthalmology 20061101 |
| Acute endophthalmitis in eyes treated prophylactically with gatifloxacin and moxifloxacin. | American journal of ophthalmology 20061101 |
| Gatifloxacin-induced dysglycemia. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20061101 |
| Delirium was likely due to multiple factors, rather than gatifloxacin induced. | Journal of the American Geriatrics Society 20061101 |
| Gatifloxacin-induced hyperglycemia: a case report and summary of the current literature. | Clinical therapeutics 20061101 |
| Fluoroquinolone resistance among Salmonella enterica serovar Paratyphi A in Pondicherry. | The Indian journal of medical research 20061101 |
| Ocular features of dengue septic shock (DSS). | The Journal of the Association of Physicians of India 20061101 |
| Chiral separation of four fluoroquinolone compounds using capillary electrophoresis with hydroxypropyl-beta-cyclodextrin as chiral selector. | Journal of chromatography. A 20061020 |
| Acute coronary syndromes and diabetes: Is intensive lipid lowering beneficial? Results of the PROVE IT-TIMI 22 trial. | European heart journal 20061001 |
| Gatifloxacin pharmacokinetics in healthy men and women. | Journal of clinical pharmacology 20061001 |
| Anticoagulation-related outcomes in patients receiving warfarin after starting levofloxacin or gatifloxacin. | Pharmacotherapy 20061001 |
| Hydrophilic acrylic intraocular lens as a drug-delivery system for fourth-generation fluoroquinolones. | Journal of cataract and refractive surgery 20061001 |
| Timely Tequin warning. | Nursing 20061001 |
| Prevalence and natural history of colonization with fluoroquinolone-resistant gram-negative bacilli in community-dwelling people with spinal cord dysfunction. | Archives of physical medicine and rehabilitation 20061001 |
| Development and validation of an HPLC-UV method for the determination of gatifloxacin in bulk material, pharmaceutical formulations, human plasma and metal complexes. | Pakistan journal of pharmaceutical sciences 20061001 |
| Effect of the fourth-generation fluoroquinolones on corneal reepithelialization after penetrating keratoplasty. | Cornea 20061001 |
| [Clinical investigation on administration method of gatifloxacin based on PK/PD theory]. | The Japanese journal of antibiotics 20061001 |
| Phototoxic drug reaction to gatifloxacin. | The Journal of the Association of Physicians of India 20061001 |
| Vibrational spectra study on quinolones antibiotics. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20060901 |
| Selecting between gatifloxacin and moxifloxacin drops in ambulatory ophthalmic surgery. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20060901 |
| Sequential therapy using high-dose esomeprazole-amoxicillin followed by gatifloxacin for Helicobacter pylori infection. | Alimentary pharmacology & therapeutics 20060901 |
| Susceptibility testing of clinical isolates of pseudomonas aeruginosa to levofloxacin, moxifloxacin, and gatifloxacin as a guide to treating pseudomonas ocular infections. | Eye & contact lens 20060901 |
| Effect of formulation factors on in vitro transcorneal permeation of gatifloxacin from aqueous drops. | AAPS PharmSciTech 20060901 |
| Indeterminable international normalized ratio with concurrent use of warfarin and gatifloxacin. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20060815 |
| Cholesterol, C-reactive protein, and cerebrovascular events following intensive and moderate statin therapy. | Journal of thrombosis and thrombolysis 20060801 |
| Lethal fragmentation of bacterial chromosomes mediated by DNA gyrase and quinolones. | Molecular microbiology 20060801 |
| Efficacy and safety of gatifloxacin for urinary tract infection in nonspecialized Korean urologic practice. | International journal of antimicrobial agents 20060801 |
| Efficacy and safety of rabeprazole, amoxicillin, and gatifloxacin after treatment failure of initial Helicobacter pylori eradication. | Helicobacter 20060801 |
| Application of two methods to determine killing of Streptococcus pneumoniae by various fluoroquinolones. | Journal of chemotherapy (Florence, Italy) 20060801 |
| Relative potential for selection of quinolone-resistance-determining-region mutations in Streptococcus pneumoniae by gemifloxacin, gatifloxacin and moxifloxacin. | Journal of chemotherapy (Florence, Italy) 20060801 |
| Abdominal aortitis due to Streptococcus pneumoniae and Enterobacter aerogenes: a case report and review. | Journal of general internal medicine 20060701 |
| Confocal assessment of the effects of fourth-generation fluoroquinolones on the cornea. | Eye & contact lens 20060701 |
| Predictive efficacy of nalidixic acid resistance as a marker of fluoroquinolone resistance in Salmonella enterica var Typhi. | The Indian journal of medical research 20060701 |
| Chromobacterium violaceum: a case report of an unusual bacterium causing puerperal sepsis. | Indian journal of pathology & microbiology 20060701 |
| Gatifloxacin and dysglycemia in older adults. | The New England journal of medicine 20060622 |
| Gatifloxacin and dysglycemia in older adults. | The New England journal of medicine 20060622 |
| Discovery of new antitubercular oxazolyl thiosemicarbazones. | Journal of medicinal chemistry 20060615 |
| Study of an alginate/HPMC-based in situ gelling ophthalmic delivery system for gatifloxacin. | International journal of pharmaceutics 20060606 |
| Rapid detection of fluoroquinolone resistance by isothermal chimeric primer-initiated amplification of nucleic acids from clinical isolates of Neisseria gonorrhoeae. | Journal of microbiological methods 20060601 |
| The formation of an antibacterial agent-apatite composite coating on a polymer surface using a metastable calcium phosphate solution. | Biomaterials 20060601 |
| Activity of gatifloxacin tested against isolates from pediatric patients: report from the SENTRY Antimicrobial Surveillance Program (North America, 1998-2003). | Diagnostic microbiology and infectious disease 20060601 |
| Gatifloxacin derivatives: synthesis, antimycobacterial activities, and inhibition of Mycobacterium tuberculosis DNA gyrase. | Bioorganic & medicinal chemistry letters 20060601 |
| Fourth-generation fluoroquinolone penetration into the aqueous humor in humans. | Ophthalmology 20060601 |
| Once daily, oral, outpatient quinolone monotherapy for low-risk cancer patients with fever and neutropenia: a pilot study of 40 patients based on validated risk-prediction rules. | Cancer 20060601 |
| Recalcitrant post-LASIK Mycobacterium chelonae keratitis eradicated after the use of fourth-generation fluoroquinolone. | Ophthalmology 20060601 |
| Effectiveness of flouroquinolone therapy for gram-negative infections within the intensive care unit setting. | The American journal of medicine 20060601 |
| Early and extended early bactericidal activity of levofloxacin, gatifloxacin and moxifloxacin in pulmonary tuberculosis. | The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 20060601 |
| Generalized status epilepticus possibly induced by gatifloxacin. | European journal of neurology 20060601 |
| Treatment of murine pneumonic Francisella tularensis infection with gatifloxacin, moxifloxacin or ciprofloxacin. | International journal of antimicrobial agents 20060501 |
| Gatifloxacin-induced delirium and psychosis in an elderly demented woman. | Journal of the American Geriatrics Society 20060501 |
| A case of gatifloxacin crystal deposits in the corneal graft of an 85-year-old man. | Eye & contact lens 20060501 |
| Electrochemical characteristics of gatifloxacin and its interaction with DNA. | Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20060501 |
| Determination of gatifloxacin and ornidazole in tablet dosage forms by high-performance thin-layer chromatography. | Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20060501 |
| Development and validation of an HPLC method for the determination of gatifloxacin stability in human plasma. | Journal of pharmaceutical and biomedical analysis 20060411 |
| People with diabetes should avoid antibiotic gatifloxacin. | CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20060411 |
| Comparative study of antimicrobial release kinetics from polymethylmethacrylate. | Clinical orthopaedics and related research 20060401 |
| Rapid microbiologic and pharmacologic evaluation of experimental compounds against Mycobacterium tuberculosis. | Antimicrobial agents and chemotherapy 20060401 |
| Effect of fluoroquinolones on plasma glucose levels in fasted and glucose-loaded mice. | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20060401 |
| Hydrophilic acrylic intraocular lens as a drug-delivery system: Pilot study. | Journal of cataract and refractive surgery 20060401 |
| Prevention of Staphylococcus aureus endophthalmitis with topical gatifloxacin in a rabbit prophylaxis model. | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20060401 |
| New tuberculosis therapy offers potential shorter treatment. Phase III trials planned in Africa. | Saudi medical journal 20060401 |
| Serial sonographic evaluation of Achilles tendons in patients taking fluoroquinolone antibiotics. | Hawaii medical journal 20060401 |
| Outpatient gatifloxacin therapy and dysglycemia in older adults. | The New England journal of medicine 20060330 |
| Serious adverse drug effects--seeing the trees through the forest. | The New England journal of medicine 20060330 |
| Determination of the extent of protein binding of antibiotics by means of an automated continuous ultrafiltration method. | International journal of pharmaceutics 20060327 |
| Glucose homeostasis abnormalities and gatifloxacin. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20060315 |
| Gatifloxacin interference with opiate urine drug screen. | Pharmacotherapy 20060301 |
| Effects of gatifloxacin on serum glucose concentration in normal and diabetic rats. | Biological & pharmaceutical bulletin 20060301 |
| Fourth-generation fluoroquinolone-resistant bacterial keratitis after refractive surgery. | Journal of cataract and refractive surgery 20060301 |
| Microbiological assay for gatifloxacin in pharmaceutical formulations. | Journal of pharmaceutical and biomedical analysis 20060213 |
| Images in clinical medicine. Radiation recall reaction after antimicrobial therapy. | The New England journal of medicine 20060209 |
| Intraocular concentrations of gatifloxacin and moxifloxacin in the anterior chamber via diffusion through the cornea using collagen shields. | Cornea 20060201 |
| Comparison of topical gatifloxacin 0.3% and ciprofloxacin 0.3% for the treatment of bacterial keratitis. | American journal of ophthalmology 20060201 |
| Vitreous penetration of topical moxifloxacin and gatifloxacin in humans. | Retina (Philadelphia, Pa.) 20060201 |
| The use of fluoroquinolones in children. | Current opinion in pediatrics 20060201 |
| Quantitative determination of gatifloxacin, levofloxacin, lomefloxacin and pefloxacin fluoroquinolonic antibiotics in pharmaceutical preparations by high-performance liquid chromatography. | Journal of pharmaceutical and biomedical analysis 20060123 |
| New tuberculosis therapy offers potential shorter treatment. | Releve epidemiologique hebdomadaire 20060113 |
| Pharmacodynamic assessment of the activity of high-dose (750 mg) levofloxacin, ciprofloxacin, and gatifloxacin against clinical strains of Pseudomonas aeruginosa. | Diagnostic microbiology and infectious disease 20060101 |
| Effects of Transcutol P on the corneal permeability of drugs and evaluation of its ocular irritation of rabbit eyes. | The Journal of pharmacy and pharmacology 20060101 |
| A comparison of gatifloxacin to ciprofloxacin in the prophylaxis of Streptococcus pneumoniae in rabbits in a LASIK model. | Eye & contact lens 20060101 |
| C-reactive protein levels and outcomes after statin therapy. | Current atherosclerosis reports 20060101 |
| Fluctuating blood glucose levels in an elderly diabetic patient. | Southern medical journal 20060101 |
| Hyperglycemia in an elderly diabetic patient: drug-drug or drug-disease interaction? | Southern medical journal 20060101 |
| Fluoroquinolones: an important class of antibiotics against tuberculosis. | Current medicinal chemistry 20060101 |
| Susceptibility of Mycobacterium tuberculosis strains to gatifloxacin and moxifloxacin by different methods. | Chemotherapy 20060101 |
| Intravitreal toxicity of levofloxacin and gatifloxacin. | Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye 20060101 |
| In vitro activity of fluoroquinolones against common respiratory pathogens. | The West Indian medical journal 20060101 |
| Determination of gatifloxacin in bulk and tablet preparations by high-performance liquid chromatography. | Journal of AOAC International 20060101 |
| Gatifloxacin-induced hallucinations in a 19-year-old man. | Psychosomatics 20060101 |
| Stronger warning for antibiotic Tequin. | FDA consumer 20060101 |
| Integrating iquix, vigamox, and zymar in the management of ocular infectious disease. | International ophthalmology clinics 20060101 |
| Zymar as an ocular therapeutic agent. | International ophthalmology clinics 20060101 |
| The dilution of benzalkonium chloride (BAK) in the tear film. | Advances in therapy 20060101 |
| Antimicrobial susceptibility of Staphylococcus aureus isolated from colonized hospital personnel. | Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20060101 |
| Gatifloxacin therapy for children: turn on the light. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20051215 |
| In vivo efficacy of fluoroquinolones against systemic tularaemia infection in mice. | The Journal of antimicrobial chemotherapy 20051201 |
| Clinical effect of gatifloxacin, 200 mg daily, on bacterial community-acquired pneumonia in the elderly. | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20051201 |
| New tuberculosis therapy offers potential shorter treatment. | Indian journal of medical sciences 20051201 |
| Hyperglycemia and gatifloxacin: a case report and summary of current literature. | The American journal of geriatric pharmacotherapy 20051201 |
| Aqueous penetration and biological activity of moxifloxacin 0.5% ophthalmic solution and gatifloxacin 0.3% solution in cataract surgery patients. | Ophthalmology 20051101 |
| Glucose homeostasis abnormalities associated with use of gatifloxacin. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20051101 |
| Effect of ensure on the oral bioavailability of gatifloxacin in healthy volunteers. | Pharmacotherapy 20051101 |
| Development of diabetes after gatifloxacin therapy. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20051101 |
| Hypoglycemia associated with the use of gatifloxacin. | The American journal of the medical sciences 20051101 |
| Effect of gatifloxacin 0.3% and moxifloxacin 0.5% ophthalmic solutions on human corneal epithelium following 2 dosing regimens. | Journal of cataract and refractive surgery 20051101 |
| The effect of the fourth-generation fluoroquinolones on corneal reepithelialization after penetrating keratoplasty. | Cornea 20051001 |
| Studies on interaction between gatifloxacin and human serum albumin as well as effect of copper(II) on the reaction. | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20051001 |
| Hypoglycemia in inpatients after gatifloxacin or levofloxacin therapy: nested case-control study. | Pharmacotherapy 20051001 |
| A retrospective, comparative evaluation of dysglycemias in hospitalized patients receiving gatifloxacin, levofloxacin, ciprofloxacin, or ceftriaxone. | Pharmacotherapy 20051001 |
| Synthesis and in-vitro cytotoxicity evaluation of gatifloxacin Mannich bases. | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20051001 |
| Electrochemical adsorptive behavior of some fluoroquinolones at carbon paste electrode. | Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20051001 |
| Gatifloxacin as a possible cause of serious postoperative hypoglycemia. | Anesthesia and analgesia 20050901 |
| Evaluation of moxifloxacin, ciprofloxacin, gatifloxacin, ofloxacin, and levofloxacin concentrations in human conjunctival tissue. | Archives of ophthalmology (Chicago, Ill. : 1960) 20050901 |
| Pharmacodynamic analysis of ceftriaxone, gatifloxacin,and levofloxacin against Streptococcus pneumoniae with the use of Monte Carlo simulation. | Pharmacotherapy 20050901 |
| Safety and efficacy of gatifloxacin therapy for children with recurrent acute otitis media (AOM) and/or AOM treatment failure. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050815 |
| Gatifloxacin therapy for children: an antibiotic still in the 'back room'. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050815 |
| The failure of antibiotics to prevent heart attacks. | BMJ (Clinical research ed.) 20050813 |
| A chiral benzoquinolizine-2-carboxylic acid arginine salt active against vancomycin-resistant Staphylococcus aureus. | Journal of medicinal chemistry 20050811 |
| Chlamydia pneumoniae and acute coronary syndrome. | The New England journal of medicine 20050804 |
| Chlamydia pneumoniae and acute coronary syndrome. | The New England journal of medicine 20050804 |
| Comparison of gatifloxacin and levofloxacin administered at various dosing regimens to hospitalised patients with community-acquired pneumonia: pharmacodynamic target attainment study using North American surveillance data for Streptococcus pneumoniae. | International journal of antimicrobial agents 20050801 |
| Current management of acute bacterial rhinosinusitis and the role of moxifloxacin. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050715 |
| Antibacterial activities of gemifloxacin, levofloxacin, gatifloxacin, moxifloxacin and erythromycin against intracellular Legionella pneumophila and Legionella micdadei in human monocytes. | The Journal of antimicrobial chemotherapy 20050701 |
| The effect of fourth-generation fluoroquinolones gatifloxacin and moxifloxacin on epithelial healing following photorefractive keratectomy. | American journal of ophthalmology 20050701 |
| Effect of gatifloxacin ophthalmic solution 0.3% on human corneal endothelial cell density and aqueous humor gatifloxacin concentration. | Current eye research 20050701 |
| Fluoroquinolone therapy in Mycobacterium chelonae keratitis after lamellar keratectomy. | Journal of cataract and refractive surgery 20050701 |
| Effects of fluoroquinolones on the migration of human phagocytes through Chlamydia pneumoniae-infected and tumor necrosis factor alpha-stimulated endothelial cells. | The Journal of urology 20050601 |
| A comparison of therapeutic regimens containing moxifloxacin 0.5% ophthalmic solution and gatifloxacin 0.3% ophthalmic solution for surgical prophylaxis in patients undergoing LASIK or LASEK. | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20050601 |
| Relative efficacy of atorvastatin 80 mg and pravastatin 40 mg in achieving the dual goals of low-density lipoprotein cholesterol <70 mg/dl and C-reactive protein <2 mg/l: an analysis of the PROVE-IT TIMI-22 trial. | Journal of the American College of Cardiology 20050517 |
| The successful treatment of gatifloxacin-resistant Staphylococcus aureus keratitis with Zymar (gatifloxacin 0.3%) in a NZW rabbit model. | American journal of ophthalmology 20050501 |
| [Evaluation of gatifloxacin-based triple therapy for refractory H. pylori]. | Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20050501 |
| Antimicrosporidial activity of (fluoro)quinolones in vitro and in vivo. | Folia parasitologica 20050501 |
| Antibiotic treatment of Chlamydia pneumoniae after acute coronary syndrome. | The New England journal of medicine 20050421 |
| Infection, antibiotics, and atherothrombosis--end of the road or new beginnings? | The New England journal of medicine 20050421 |
| Gatifloxacin therapy associated with hypoglycemia. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050415 |
| Comparison of gatifloxacin, moxifloxacin and ciprofloxacin for treatment of experimental Burkholderia pseudomallei infection. | The Journal of antimicrobial chemotherapy 20050401 |
| Randomized, investigator-blinded, multicenter study of gatifloxacin versus amoxicillin/clavulanate treatment of recurrent and nonresponsive otitis media in children. | The Pediatric infectious disease journal 20050401 |
| Randomized, investigator-blinded, multicenter, comparative study of gatifloxacin versus amoxicillin/clavulanate in recurrent otitis media and acute otitis media treatment failure in children. | The Pediatric infectious disease journal 20050401 |
| Development and validation of an UV spectrophotometric method for determination of gatifloxacin in tablets. | Die Pharmazie 20050401 |
| In vitro activity of fluoroquinolones against Mycobacterium tuberculosis. | Journal of chemotherapy (Florence, Italy) 20050401 |
| An open multicenter study of the use of gatifloxacin for the treatment of non-complicated acute bacterial rhinosinusitis in adults. | The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20050401 |
| Penetration of topically applied gatifloxacin 0.3%, moxifloxacin 0.5%, and ciprofloxacin 0.3% into the aqueous humor. | Ophthalmology 20050301 |
| Acinetobacter as a causative agent in preseptal cellulitis. | Optometry (St. Louis, Mo.) 20050301 |
| Crystallization of gatifloxacin after penetrating keratoplasty. | Eye & contact lens 20050301 |
| A randomized, investigator- masked clinical trial comparing the efficacy and safety of gatifloxacin 0.3% administered BID versus QID for the treatment BID versus QID for the treatment of acute bacterial conjunctivitis of acute bacterial conjunctivitis. | Current medical research and opinion 20050301 |
| Gatifloxacin-induced cholestatic hepatitis--a challenging diagnosis. | Tennessee medicine : journal of the Tennessee Medical Association 20050301 |
| Spectrofluorimetric and micelle-enhanced spectrofluorimetric determination of gatifloxacin in human urine and serum. | Journal of pharmaceutical and biomedical analysis 20050223 |
| Stable antimicrobial susceptibility rates for clinical isolates of Pseudomonas aeruginosa from the 2001-2003 tracking resistance in the United States today surveillance studies. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050215 |
| Comparison of ophthalmic gatifloxacin 0.3% and ciprofloxacin 0.3% in healing of corneal ulcers associated with Pseudomonas aeruginosa-induced ulcerative keratitis in rabbits. | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20050201 |
| [Antimicrobial susceptibility surveillance of recent isolates from ophthalmological infections to gatifloxacin and other antimicrobial drugs]. | The Japanese journal of antibiotics 20050201 |
| C-reactive protein levels and outcomes after statin therapy. | The New England journal of medicine 20050106 |
| Coadministration of gatifloxacin and multivitamin preparation containing minerals: potential treatment failure in an elderly patient. | The Annals of pharmacotherapy 20050101 |
| Comparison of corneal surface effects of gatifloxacin and moxifloxacin using intensive and prolonged dosing protocols. | Cornea 20050101 |
| Pancreatic abscess secondary to Alcaligenes faecalis. | The American journal of the medical sciences 20050101 |
| Comparison of in vitro susceptibilities of ocular bacterial isolates to gatifloxacin and other topical antibiotics. | Ophthalmic research 20050101 |
| Gatifloxacin: a review of its use in the treatment of bacterial infections in the US. | Drugs 20050101 |
| Ocular penetration of moxifloxacin 0.5% and gatifloxacin 0.3% ophthalmic solutions into the aqueous humor following topical administration prior to routine cataract surgery. | Current medical research and opinion 20050101 |
| Severe hyperglycemia during renally adjusted gatifloxacin therapy. | The Annals of pharmacotherapy 20050101 |
| [Flouroquinolone activity in clinical isolates of Streptococcus pneumoniae with different susceptibility to penicilline: an epidemiological study in five cities of Mexico]. | Gaceta medica de Mexico 20050101 |
| New, simple and validated UV-spectrophotometric methods for the estimation of gatifloxacin in bulk and formulations. | Farmaco (Societa chimica italiana : 1989) 20050101 |
| Gatifloxacin-induced hyperglycemia. | Annals of internal medicine 20041221 |
| Hypoglycemia, hyperglycemia, and gatifloxacin. | Annals of internal medicine 20041221 |
| Efficacy of the latest fluoroquinolones against experimental Yersinia pestis. | International journal of antimicrobial agents 20041201 |
| Antibiotics for coronary disease: it's time to move on. | Clinical cardiology 20041201 |
| Action of fluoroquinolones and Linezolid on logarithmic- and stationary-phase culture of Mycobacterium tuberculosis. | Chemotherapy 20041101 |
| In vitro antimicrobial activity of gatifloxacin compared with other quinolones against clinical isolates from cancer patients. | Chemotherapy 20041101 |
| A comparison of the fourth-generation fluoroquinolones gatifloxacin 0.3% and moxifloxacin 0.5% in terms of ocular tolerability. | Current medical research and opinion 20041101 |
| Pharmacodynamic modeling of carbapenems and fluoroquinolones against bacteria that produce extended-spectrum beta-lactamases. | Clinical therapeutics 20041101 |
| [New fluoroquinolones: levofloxacin, moxifloxacin and gatifloxacin]. | Nederlands tijdschrift voor geneeskunde 20041023 |
| Simultaneous determination of levofloxacin, gatifloxacin and moxifloxacin in serum by liquid chromatography with column switching. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041015 |
| Comparative penetration of moxifloxacin and gatifloxacin in rabbit aqueous humor after topical dosing. | Journal of cataract and refractive surgery 20041001 |
| Gatifloxacin induced torsades de pointes. | Pacing and clinical electrophysiology : PACE 20041001 |
| Outbreak of Clostridium difficile infection and gatifloxacin use in a long-term care facility. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040915 |
| In vivo pharmacodynamic efficacy of gatifloxacin against Streptococcus pneumoniae in an experimental model of pneumonia: impact of the low levels of fluoroquinolone resistance on the enrichment of resistant mutants. | The Journal of antimicrobial chemotherapy 20040901 |
| Vitreous and aqueous penetration of orally administered gatifloxacin in humans. | Archives of ophthalmology (Chicago, Ill. : 1960) 20040901 |
| A study to determine the pharmacokinetics of gatifloxacin following a single oral dose. | Journal of the Indian Medical Association 20040901 |
| Effects of fluoroquinolones on insulin secretion and beta-cell ATP-sensitive K+ channels. | European journal of pharmacology 20040816 |
| The incidence of Clostridium difficile-associated and non-C. difficile-associated diarrhea after use of gatifloxacin and levofloxacin in an acute-care facility. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040815 |
| In vitro antibacterial activity of fluoroquinolones against Porphyromonas gingivalis strains. | The Journal of antimicrobial chemotherapy 20040801 |
| Fourth-generation fluoroquinolones: new topical agents in the war on ocular bacterial infections. | Current opinion in ophthalmology 20040801 |
| Surveillance of the susceptibility of ocular bacterial pathogens to the fluoroquinolone gatifloxacin and other antimicrobials in Europe during 2001/2002. | The Journal of infection 20040801 |
| Urinary concentrations and bactericidal activities of newer fluoroquinolones in healthy volunteers. | International journal of antimicrobial agents 20040801 |
| Comparative efficacy of topical gatifloxacin with ciprofloxacin, amikacin, and clarithromycin in the treatment of experimental Mycobacterium chelonae keratitis. | Archives of ophthalmology (Chicago, Ill. : 1960) 20040801 |
| Post-exposure prophylaxis of systemic anthrax in mice and treatment with fluoroquinolones. | The Journal of antimicrobial chemotherapy 20040701 |
| Severe and resistant hypoglycemia associated with concomitant gatifloxacin and glyburide therapy. | Pharmacotherapy 20040701 |
| Corneal intrastromal gatifloxacin crystal deposits after penetrating keratoplasty. | Eye & contact lens 20040701 |
| Synthesis of new fluoroquinolones and evaluation of their in vitro activity on Toxoplasma gondii and Plasmodium spp. | Bioorganic & medicinal chemistry letters 20040607 |
| Use of pharmacodynamic end points in the evaluation of gatifloxacin for the treatment of acute maxillary sinusitis. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040601 |
| Efficacy of two rabeprazole/gatifloxacin-based triple therapies for Helicobacter pylori infection. | Helicobacter 20040601 |
| Once-daily oral gatifloxacin vs three-times-daily co-amoxiclav in the treatment of patients with community-acquired pneumonia. | Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20040601 |
| Gatifloxacin 400 mg as a single shot or 200 mg once daily for 3 days is as effective as ciprofloxacin 250 mg twice daily for the treatment of patients with uncomplicated urinary tract infections. | International journal of antimicrobial agents 20040601 |
| Aqueous penetration of gatifloxacin and levofloxacin into the rabbit aqueous humor following topical dosing. | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20040601 |
| Pharmacodynamics and bactericidal activity of gatifloxacin in experimental pneumonia caused by penicillin-resistant Streptococcus pneumoniae. | Chemotherapy 20040601 |
| Monotherapy versus dual therapy for community-acquired pneumonia in hospitalized patients. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040515 |
| 'Me-too' products--friend or foe? | The New England journal of medicine 20040513 |
| A randomised, double-blind, double-dummy comparative study of gatifloxacin with clarithromycin in the treatment of community-acquired pneumonia. | Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20040501 |
| Potential role of fluoroquinolone therapy in childhood otitis media. | The Pediatric infectious disease journal 20040501 |
| Short-course treatment regimen to identify potential antituberculous agents in a murine model of tuberculosis. | The Journal of antimicrobial chemotherapy 20040401 |
| Possible gatifloxacin-induced hyperglycemia. | The Annals of pharmacotherapy 20040401 |
| Mycobacterium tuberculosis DNA gyrase: interaction with quinolones and correlation with antimycobacterial drug activity. | Antimicrobial agents and chemotherapy 20040401 |
| Comparative in vitro activities of three new quinolones and azithromycin against aerobic pathogens causing respiratory tract and abdominal wound infections. | Chemotherapy 20040401 |
| Antimicrobial therapies for pulmonary Klebsiella pneumoniae infection in B6D2F1/J mice immunocompromised by use of sublethal irradiation. | Comparative medicine 20040401 |
| Ophthalmic moxifloxacin (Vigamox) and gatifloxacin (Zymar). | The Medical letter on drugs and therapeutics 20040329 |
| Mutant prevention concentration: comparison of fluoroquinolones and linezolid with Mycobacterium tuberculosis. | The Journal of antimicrobial chemotherapy 20040301 |
| Outbreak of Clostridium difficile infection in a long-term care facility: association with gatifloxacin use. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040301 |
| Torsades de pointes associated with fluoroquinolones: importance of concomitant risk factors. | Clinical pharmacology and therapeutics 20040301 |
| Susceptibility testing of Singapore strains of Mycoplasma hominis to tetracycline, gatifloxacin, moxifloxacin, ciprofloxacin, clindamycin, and azithromycin by the Etest method. | Diagnostic microbiology and infectious disease 20040301 |
| Fluoroquinolone resistance in ophthalmology and the potential role for newer ophthalmic fluoroquinolones. | Survey of ophthalmology 20040301 |
| Urinary bactericidal activity, urinary excretion and plasma concentrations of gatifloxacin (400 mg) versus ciprofloxacin (500 mg) in healthy volunteers after a single oral dose. | International journal of antimicrobial agents 20040301 |
| Gatifloxacin 200 mg or 400 mg once daily is as effective as ciprofloxacin 500 mg twice daily for the treatment of patients with acute pyelonephritis or complicated urinary tract infections. | International journal of antimicrobial agents 20040301 |
| Binding interaction of gatifloxacin with bovine serum albumin. | Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20040301 |
| Mutations in the gyrA and parC genes and in vitro activities of fluoroquinolones in 91 clinical isolates of Neisseria gonorrhoeae in Japan. | Sexually transmitted diseases 20040301 |
| Disappearance of rectal mucosa-associated lymphoid tissue lymphoma following antibiotic therapy. | Digestive diseases and sciences 20040301 |
| [Synthesis and antibacterial activity of 7-(7-aminomethyl-5-azaspiro [2,4] hept-5-yl)-1-cyclopropyl-6-fluoro-8-methoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and its analogues]. | Yao xue xue bao = Acta pharmaceutica Sinica 20040301 |
| In vivo experimental approach for the risk assessment of fluoroquinolone antibacterial agents-induced long QT syndrome. | European journal of pharmacology 20040220 |
| Possible gatifloxacin-induced seizure. | The Annals of pharmacotherapy 20040201 |
| Pharmacologic considerations for cataract surgery. | Current opinion in ophthalmology 20040201 |
| Gatifloxacin in the treatment of community-acquired pneumonias: a comparative trial of ceftriaxone, with or without macrolides, in hospitalized adult patients with mild to moderately severe pneumonia. | The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20040201 |
| Gatifloxacin-induced hepatotoxicity and acute pancreatitis. | Annals of internal medicine 20040106 |
| Gatifloxacin and prolonged QT interval. | The American journal of the medical sciences 20040101 |
| Concentration-dependent changes in the susceptibility and killing of Staphylococcus aureus in an in vitro dynamic model that simulates normal and impaired gatifloxacin elimination. | International journal of antimicrobial agents 20040101 |
| Treatment of rabbit corneal infections with ophthalmic gatifloxacin: a concentration dependence study. | Advances in therapy 20040101 |
| Severe hyperglycemia during gatifloxacin therapy in patients without diabetes. | Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20040101 |
| Gatifloxacin-induced hyperglycemia. | Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20040101 |
| [Final confirmation of inefficiency of antibiotics in secondary prevention of coronary heart disease. Results of PROVE IT (gatifloxacin trial) and ACES]. | Kardiologiia 20040101 |
| Fluoroquinolones as chemotherapeutics against mycobacterial infections. | Current pharmaceutical design 20040101 |
| Determination of gatifloxacin in human serum and urine by high-performance liquid chromatography with ultraviolet detection. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20031205 |
| Antibiotic treatment of atherosclerosis. | Current opinion in lipidology 20031201 |
| In vitro pharmacodynamic activity of gatifloxacin, gemifloxacin, moxifloxacin and levofloxacin against Streptococcus pneumoniae containing specific mutations in DNA gyrase and topoisomerase IV. | Diagnostic microbiology and infectious disease 20031201 |
| Serum bactericidal activity of the methoxyfluoroquinolones gatifloxacin and moxifloxacin against clinical isolates of Staphylococcus species: are the susceptibility breakpoints too high? | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20031115 |
| Gatifloxacin, gemifloxacin, and moxifloxacin: the role of 3 newer fluoroquinolones. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20031101 |
| Bacteriologic and clinical efficacy of oral gatifloxacin for the treatment of recurrent/nonresponsive acute otitis media: an open label, noncomparative, double tympanocentesis study. | The Pediatric infectious disease journal 20031101 |
| Open label, multicenter study of gatifloxacin treatment of recurrent otitis media and acute otitis media treatment failure. | The Pediatric infectious disease journal 20031101 |
| In vitro activity of gatifloxacin, a new fluoroquinolone, against 204 anaerobes compared to seven other compounds. | Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20031101 |
| Accumulation of garenoxacin by Bacteroides fragilis compared with that of five fluoroquinolones. | The Journal of antimicrobial chemotherapy 20031001 |
| Gatifloxacin in community-acquired respiratory tract infection. | Expert opinion on pharmacotherapy 20031001 |
| [Comparative in vitro activity of garenoxacin (BMS-284756). Sentry program, Spain (1999-2000)]. | Enfermedades infecciosas y microbiologia clinica 20031001 |
| Gatifloxacin and the elderly: pharmacokinetic-pharmacodynamic rationale for a potential age-related dose reduction. | The Journal of antimicrobial chemotherapy 20030901 |
| Gatifloxacin and moxifloxacin: an in vitro susceptibility comparison to levofloxacin, ciprofloxacin, and ofloxacin using bacterial keratitis isolates. | American journal of ophthalmology 20030901 |
| The effect of pharmacokinetic/pharmacodynamic (PK/PD) parameters of gatifloxacin on its bactericidal activity and resistance selectivity against clinical isolates of Streptococcus pneumoniae. | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20030901 |
| [Analysis of the response factors of different quinolones detected by evaporative light-scattering detector]. | Yao xue xue bao = Acta pharmaceutica Sinica 20030901 |
| Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. | Bioorganic & medicinal chemistry letters 20030818 |
| Discovery of (3S)-amino-(4R)-ethylpiperidinyl quinolones as potent antibacterial agents with a broad spectrum of activity and activity against resistant pathogens. | Journal of medicinal chemistry 20030814 |
| Comparative antimicrobial activities of gatifloxacin, sitafloxacin and levofloxacin against Mycobacterium tuberculosis replicating within Mono Mac 6 human macrophage and A-549 type II alveolar cell lines. | The Journal of antimicrobial chemotherapy 20030801 |
| Gatifloxacin and ethionamide as the foundation for therapy of tuberculosis. | Antimicrobial agents and chemotherapy 20030801 |
| Fluoroquinolone therapy in multiple-drug resistant staphylococcal keratitis after lamellar keratectomy in a rabbit model. | American journal of ophthalmology 20030701 |
| Antimicrobial susceptibilities of 40 isolates of Bacillus anthracis isolated in Turkey. | International journal of antimicrobial agents 20030701 |
| A novel method of estimating cost of therapy by using patient population characteristics: analysis of fluoroquinolones in various populations with different distributions of renal function. | Pharmacotherapy 20030701 |
| In vitro activity of new fluoroquinolones and linezolid against non-tuberculous mycobacteria. | International journal of antimicrobial agents 20030601 |
| Re-evaluation of quality control guidelines for gatifloxacin and garenoxacin (BMS284756) when susceptibility testing Haemophilus influenzae and Streptococcus pneumoniae. | Diagnostic microbiology and infectious disease 20030601 |
| [Antibacterial property and clinical effect of gatifloxacin, a novel quinolone antibacterial agent]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20030601 |
| In vitro activity of gatifloxacin alone and in combination with cefepime, meropenem, piperacillin and gentamicin against multidrug-resistant organisms. | The Journal of antimicrobial chemotherapy 20030501 |
| Bioavailability of gatifloxacin by gastric tube administration with and without concomitant enteral feeding in critically ill patients. | Critical care medicine 20030501 |
| Randomized, open-label, parallel-group, multicenter study of the efficacy and tolerability of IV gatifloxacin with the option for oral stepdown gatifloxacin versus IV ceftriaxone (with or without erythromycin or clarithromycin) with the option for oral stepdown clarithromycin for treatment of patients with mild to moderate community-acquired pneumonia requiring hospitalization. | Clinical therapeutics 20030501 |
| Synergic activity of fluoroquinolones and linezolid against Mycobacterium tuberculosis. | International journal of antimicrobial agents 20030401 |
| Synthesis and structure-activity relationships of 5-amino-6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-8-methylquinolonecarboxylic acid antibacterials having fluorinated 7-[(3R)-3-(1-aminocyclopropan-1-yl)pyrrolidin-1-yl] substituents. | Journal of medicinal chemistry 20030313 |
| Vitreous and aqueous penetration of orally administered gatifloxacin in humans. | Archives of ophthalmology (Chicago, Ill. : 1960) 20030301 |
| [Pneumococcus and quinolone resistance]. | Archivos de bronconeumologia 20030301 |
| Randomised double-blind comparison of oral gatifloxacin and co-amoxiclav for acute exacerbation of chronic Bronchitis. | European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20030301 |
| Bradycardic syncope in 2 patients who recently began gatifloxacin treatment. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20030201 |
| Sterilizing activities of fluoroquinolones against rifampin-tolerant populations of Mycobacterium tuberculosis. | Antimicrobial agents and chemotherapy 20030201 |
| Rapid in vivo screening of experimental drugs for tuberculosis using gamma interferon gene-disrupted mice. | Antimicrobial agents and chemotherapy 20030201 |
| An open label, multicenter, non-comparative study of the efficacy and safety of oral gatifloxacin in the treatment of community-acquired pneumonia: a Brazilian study in five centers. | The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20030201 |
| Delirium associated with gatifloxacin. | Psychosomatics 20030101 |
| Lack of bioequivalence of gatifloxacin when coadministered with calcium-fortified orange juice in healthy volunteers. | Journal of clinical pharmacology 20030101 |
| Gatifloxacin precipitation of psychosis in Alzheimer disease. | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 20030101 |
| Hypoglycemia and hyperglycemia associated with gatifloxacin use in elderly patients. | The Journal of the American Board of Family Practice 20030101 |
| Antibacterial activity of the fourth-generation fluoroquinolones gatifloxacin and moxifloxacin against ocular pathogens. | Advances in therapy 20030101 |
| In vitro activity of moxifloxacin, levofloxacin, gatifloxacin and linezolid against Mycobacterium tuberculosis. | International journal of antimicrobial agents 20021201 |
| Bactericidal activity of levofloxacin, gatifloxacin, penicillin, meropenem and rokitamycin against Bacillus anthracis clinical isolates. | The Journal of antimicrobial chemotherapy 20021201 |
| In vitro activity of gemifloxacin against recent clinical isolates of bacteria in Korea. | Journal of Korean medical science 20021201 |
| [In vitro antibacterial activity of prulifloxacin, a new oral fluoroquinolone]. | The Japanese journal of antibiotics 20021201 |
| [In vitro short-term bactericidal activity and accumulation of NM394, the active metabolite of prulifloxacin, for Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa: comparison with ciprofloxacin, levofloxacin, and gatifloxacin]. | The Japanese journal of antibiotics 20021201 |
| [Antibacterial activity of gatifloxacin against various fresh clinical isolates in 2002]. | The Japanese journal of antibiotics 20021201 |
| [Inhibitory activity of NM394, the active form of prodrug prulifloxacin against type II topoisomerase from Pseudomonas aeruginosa]. | The Japanese journal of antibiotics 20021201 |
| Possible gatifloxacin-induced hypoglycemia. | The Annals of pharmacotherapy 20021101 |
| Comment: possible gatifloxacin-induced fulminant hepatic failure. | The Annals of pharmacotherapy 20021101 |
| Oral gatifloxacin-induced ataxia. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20021001 |
| What's new about gatifloxacin (Tequin)? | Urologic nursing 20021001 |
| Interference of sub-inhibitory concentrations of gatifloxacin on various determinants of bacterial virulence. | Journal of chemotherapy (Florence, Italy) 20021001 |
| Influence of anti-alginate serum combined with gatifloxacin on mucoid pseudomonas aeruginosa biofilm morphology. | Zhonghua yi xue za zhi 20020925 |
| Community-based treatment of acute uncomplicated bacterial rhinosinusitis with gatifloxacin. | Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20020901 |
| Comparative killing rates of gatifloxacin and ciprofloxacin against 14 clinical isolates: impact of bacterial strain and antibiotic concentration. | Diagnostic microbiology and infectious disease 20020901 |
| Safety and efficacy of gatifloxacin in community-acquired pneumonia: rationale for the Tequin Clinical Experience Study (TeqCES). | Diagnostic microbiology and infectious disease 20020901 |
| Gatifloxacin phase IV surveillance trial (TeqCES study) utilizing 5000 primary care physician practices: report of pathogens isolated and susceptibility patterns in community-acquired respiratory tract infections. | Diagnostic microbiology and infectious disease 20020901 |
| Oral gatifloxacin in outpatient community-acquired pneumonia: results from TeqCES, a community-based, open-label, multicenter study. | Diagnostic microbiology and infectious disease 20020901 |
| Gatifloxacin used for therapy of outpatient community-acquired pneumonia caused by Streptococcus pneumoniae. | Diagnostic microbiology and infectious disease 20020901 |
| Haemophilus influenzae in respiratory tract infections in community-based clinical practice: therapy with gatifloxacin. | Diagnostic microbiology and infectious disease 20020901 |
| Gatifloxacin in community-based treatment of acute respiratory tract infections in the elderly. | Diagnostic microbiology and infectious disease 20020901 |
| Efficacy and safety of gatifloxacin in elderly outpatients with community-acquired pneumonia. | Diagnostic microbiology and infectious disease 20020901 |
| Implications of TeqCES: efficacy and safety of gatifloxacin in community-acquired pneumonia. | Diagnostic microbiology and infectious disease 20020901 |
| Severe and persistent hypoglycemia due to gatifloxacin interaction with oral hypoglycemic agents. | The American journal of medicine 20020815 |
| In vitro assessment of gatifloxacin spectrum and potency tested against Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae isolates from the Asia-Western Pacific component of the SENTRY antimicrobial surveillance program (1998-1999). | Diagnostic microbiology and infectious disease 20020801 |
| Minimal interaction between gatifloxacin and oxycodone. | Journal of clinical pharmacology 20020801 |
| Treatment of adults with community-acquired respiratory tract infections: results of a multicentric clinical trial with gatifloxacin. | The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20020801 |
| Effectiveness, safety and tolerability of gatifloxacin, a new 8-methoxyfluoroquinolone, in the treatment of outpatients with community-acquired pneumonia: a Brazilian study. | The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20020801 |
| Single and multi-step resistance selection study in Streptococcus pneumoniae comparing ceftriaxone with levofloxacin, gatifloxacin and moxifloxacin. | International journal of antimicrobial agents 20020801 |
| The expanding role of fluoroquinolones. | The American journal of medicine 20020708 |
| Comparative activity of gatifloxacin and other antibiotics against 4009 clinical isolates of Streptococcus pneumoniae in the United States during 1999-2000. | Diagnostic microbiology and infectious disease 20020701 |
| Oral bioavailability of gatifloxacin in healthy volunteers under fasting and fed conditions. | Chemotherapy 20020701 |
| Multiple-dose pharmacokinetics and excretion balance of gatifloxacin, a new fluoroquinolone antibiotic, following oral administration to healthy Caucasian volunteers. | Chemotherapy 20020701 |
| Possible interaction between gatifloxacin and warfarin. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20020615 |
| Antimicrobial-associated acute hepatitis. | Pharmacotherapy 20020601 |
| Concomitant administration of drugs known to decrease the systemic availability of gatifloxacin. | Pharmacotherapy 20020601 |
| Efficacy and tolerability of gatifloxacin in community treatment of acute exacerbations of chronic bronchitis. | Clinical therapeutics 20020601 |
| [The role of respiratory quinolone in treatment of respiratory tract infections: focusing on gatifloxacin]. | The Japanese journal of antibiotics 20020601 |
| [Impurity analysis and their structure determination of gatifloxacin]. | Yao xue xue bao = Acta pharmaceutica Sinica 20020601 |
| Soundalike drugs. A Ticlid-ish situation. | Nursing 20020501 |
| In vitro and in vivo activities of gatifloxacin against Mycobacterium tuberculosis. | Antimicrobial agents and chemotherapy 20020401 |
| Design of the Pravastatin or Atorvastatin Evaluation and Infection Therapy (PROVE IT)-TIMI 22 trial. | The American journal of cardiology 20020401 |
| Fourth generation fluoroquinolones: new weapons in the arsenal of ophthalmic antibiotics. | American journal of ophthalmology 20020401 |
| Anti-Mycobacterium tuberculosis activities of new fluoroquinolones in combination with other antituberculous drugs. | The Journal of infection 20020401 |
| Gatifloxacin-associated corrected QT interval prolongation, torsades de pointes, and ventricular fibrillation in patients with known risk factors. | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20020315 |
| In vitro antibacterial activities of DQ-113, a potent quinolone, against clinical isolates. | Antimicrobial agents and chemotherapy 20020301 |
| Single-dose fluoroquinolone therapy of acute uncomplicated urinary tract infection in women: results from a randomized, double-blind, multicenter trial comparing single-dose to 3-day fluoroquinolone regimens. | Urology 20020301 |
| Effects of gatifloxacin on phagocytosis, intracellular killing and oxidant radical production by human polymorphonuclear neutrophils. | International journal of antimicrobial agents 20020301 |
| Antimicrobial activities of clarithromycin, gatifloxacin and sitafloxacin, in combination with various antimycobacterial drugs against extracellular and intramacrophage Mycobacterium avium complex. | International journal of antimicrobial agents 20020201 |
| In vitro activity of 11 antimicrobial agents, including gatifloxacin and GAR936, tested against clinical isolates of Mycobacterium marinum. | Diagnostic microbiology and infectious disease 20020201 |
| A randomized, double-blind, multicenter comparison of gatifloxacin versus ciprofloxacin in the treatment of complicated urinary tract infection and pyelonephritis. | Clinical therapeutics 20020201 |
| A multicenter, randomized, investigator-blinded study of 5- and 10-day gatifloxacin versus 10-day amoxicillin/clavulanate in patients with acute bacterial sinusitis. | Clinical therapeutics 20020201 |
| Bactericidal mechanism of gatifloxacin compared with other quinolones. | The Journal of antimicrobial chemotherapy 20020101 |
| Gatifloxacin: a review of its use in the management of bacterial infections. | Drugs 20020101 |
| Effects of sub-minimum inhibitory concentrations of gatifloxacin on the inhibition of Staphylococcus aureus and Escherichia coli adherence. | Arzneimittel-Forschung 20020101 |
| E test susceptibility testing of nosocomial Clostridium difficile isolates against metronidazole, vancomycin, fusidic acid and the novel agents moxifloxacin, gatifloxacin, and linezolid. | European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20020101 |
| Possible gatifloxacin-induced fulminant hepatic failure. | The Annals of pharmacotherapy 20020101 |
| IV-to-oral switch therapy for community-acquired pneumonia requiring hospitalization: focus on gatifloxacin. | Advances in therapy 20020101 |
| Vitreous penetration of orally administered gatifloxacin in humans. | Transactions of the American Ophthalmological Society 20020101 |
| Pharmacodynamic profiling of levofloxacin and gatifloxacin using Monte Carlo simulation for community-acquired isolates of Streptococcus pneumoniae. | The American journal of medicine 20011217 |
| The pharmacodynamics of gatifloxacin and ciprofloxacin for pneumococci in an in vitro dynamic model: prediction of equiefficient doses. | The Journal of antimicrobial chemotherapy 20011201 |
| Rates of torsades de pointes associated with ciprofloxacin, ofloxacin, levofloxacin, gatifloxacin, and moxifloxacin. | Pharmacotherapy 20011201 |
| Gatifloxacin-associated acute hepatitis. | Pharmacotherapy 20011201 |
| [Activity of new fluoroquinolones against clinical isolates of Acinetobacter baumannii]. | Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 20011201 |
| Comparative antimicrobial activity of gatifloxacin with ciprofloxacin and beta-lactams against gram-positive bacteria. | Diagnostic microbiology and infectious disease 20011101 |
| Spectrum and activity of three contemporary fluoroquinolones tested against Pseudomonas aeruginosa isolates from urinary tract infections in the SENTRY Antimicrobial Surveillance Program (Europe and the Americas; 2000): more alike than different! | Diagnostic microbiology and infectious disease 20011101 |
| Myoclonus and generalized seizures associated with gatifloxacin treatment. | Archives of internal medicine 20011008 |
| Single- and multi-step resistance selection study of gemifloxacin compared with trovafloxacin, ciprofloxacin, gatifloxacin and moxifloxacin in Streptococcus pneumoniae. | The Journal of antimicrobial chemotherapy 20010901 |
| [Effect of macrolides on biofilm of mucoid Pseudomonas aeruginosa]. | Zhonghua yi xue za zhi 20010810 |
| [New quinolone. Better effectiveness in problem cases]. | MMW Fortschritte der Medizin 20010726 |
| Concentrations of gatifloxacin in plasma and pulmonary compartments following a single 400 mg oral dose in patients undergoing fibre-optic bronchoscopy. | The Journal of antimicrobial chemotherapy 20010701 |
| Activity of gatifloxacin against strains resistant to ofloxacin and ciprofloxacin and its ability to select for less susceptible bacterial variants. | International journal of antimicrobial agents 20010701 |
| Antimicrobial activity of moxifloxacin, gatifloxacin and six fluoroquinolones against Streptococcus pneumoniae. | The Journal of antimicrobial chemotherapy 20010601 |
| Conventional dogma applied to quinolones? Time for a change. | The Journal of antimicrobial chemotherapy 20010601 |
| Microbial drug resistance and the roles of the new antibiotics. | Cleveland Clinic journal of medicine 20010601 |
| Efficacy of gatifloxacin alone and in combination with cefepime against penicillin-resistant Streptococcus pneumoniae in a rabbit meningitis model and in vitro. | The Journal of antimicrobial chemotherapy 20010501 |
| Cost-effectiveness of gatifloxacin vs ceftriaxone with a macrolide for the treatment of community-acquired pneumonia. | Chest 20010501 |
| Can antimicrobial susceptibility testing results for ciprofloxacin or levofloxacin predict susceptibility to a newer fluoroquinolone, gatifloxacin?: Report from The SENTRY Antimicrobial Surveillance Program (1997-99). | Diagnostic microbiology and infectious disease 20010401 |
| Activity of BMS284756 against 2,681 recent clinical isolates of Haemophilus influenzae and Moraxella catarrhalis: Report from The SENTRY Antimicrobial Surveillance Program (2000) in Europe, Canada and the United States. | Diagnostic microbiology and infectious disease 20010401 |
| In vitro activity of fluoroquinolones (gatifloxacin, levofloxacin and trovafloxacin) and seven other antibiotics against Streptococcus pneumoniae. | The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20010401 |
| Potassium current antagonist properties and proarrhythmic consequences of quinolone antibiotics. | The Journal of pharmacology and experimental therapeutics 20010301 |
| Gatifloxacin-induced QTc prolongation and ventricular tachycardia. | Pharmacotherapy 20010301 |
| What do the new antimicrobials offer? Weighing the advantages and disadvantages compared with traditional agents. | Postgraduate medicine 20010301 |
| Single-dose gatifloxacin compared with ofloxacin for the treatment of uncomplicated gonorrhea: a randomized, double-blind, multicenter trial. | Sexually transmitted diseases 20010301 |
| [Broad-spectrum fluoroquinolones. Passed safety tests up to now]. | MMW Fortschritte der Medizin 20010208 |
| Activity of gatifloxacin and ciprofloxacin in combination with other antimicrobial agents. | International journal of antimicrobial agents 20010201 |
| Activity of gatifloxacin alone or in combination with pyrimethamine or gamma interferon against Toxoplasma gondii. | Antimicrobial agents and chemotherapy 20010101 |
| Gatifloxacin, an advanced 8-methoxy fluoroquinolone. | Pharmacotherapy 20010101 |
| Comparison of 5-day, short-course gatifloxacin therapy with 7-day gatifloxacin therapy and 10-day clarithromycin therapy for acute exacerbation of chronic bronchitis. | Clinical therapeutics 20010101 |
| Determination of gatifloxacin in human plasma by liquid chromatography/electrospray tandem mass spectrometry. | Rapid communications in mass spectrometry : RCM 20010101 |
| Mutant prevention concentration as a measure of fluoroquinolone potency against mycobacteria. | Antimicrobial agents and chemotherapy 20001201 |
| Prediction of quinolone activity against Mycobacterium avium by molecular topology and virtual computational screening. | Antimicrobial agents and chemotherapy 20001001 |
| Anti-toxoplasma activities of 24 quinolones and fluoroquinolones in vitro: prediction of activity by molecular topology and virtual computational techniques. | Antimicrobial agents and chemotherapy 20001001 |
| Mutant prevention concentration as a measure of antibiotic potency: studies with clinical isolates of Mycobacterium tuberculosis. | Antimicrobial agents and chemotherapy 20000901 |
| Antimycobacterial activities of novel levofloxacin analogues. | Antimicrobial agents and chemotherapy 20000801 |
| In vitro antibacterial spectrum of a new broad-spectrum 8-methoxy fluoroquinolone, gatifloxacin. | The Journal of antimicrobial chemotherapy 20000401 |
| Comparative in vitro antimicrobial activities of the newly synthesized quinolone HSR-903, sitafloxacin (DU-6859a), gatifloxacin (AM-1155), and levofloxacin against Mycobacterium tuberculosis and Mycobacterium avium complex. | Antimicrobial agents and chemotherapy 19991201 |
| The activity of the methylpiperazinyl fluoroquinolone CG 5501: a comparison with other fluoroquinolones. | The Journal of antimicrobial chemotherapy 19970401 |
| N-1-tert-butyl-substituted quinolones: in vitro anti-Mycobacterium avium activities and structure-activity relationship studies. | Antimicrobial agents and chemotherapy 19961101 |
| Structure-activity relationships of quinolone agents against mycobacteria: effect of structural modifications at the 8 position. | Antimicrobial agents and chemotherapy 19961001 |
| [In vitro anti-MAC activities of new quinolones in focus (1)]. | Kekkaku : [Tuberculosis] 19960901 |
| [In vitro anti-MAC activities of new quinolones in focus (2)]. | Kekkaku : [Tuberculosis] 19960901 |
| Comparative antimycobacterial activities of the newly synthesized quinolone AM-1155, sparfloxacin, and ofloxacin. | Antimicrobial agents and chemotherapy 19930601 |
| In vitro and in vivo antibacterial activities of AM-1155, a new 6-fluoro-8-methoxy quinolone. | Antimicrobial agents and chemotherapy 19921001 |
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