CAS 1124-11-4 | 2,3,5,6-Tetramethylpyrazine | CAS Number 1124-11-4

Title	Journal
Effects of tetramethylpyrazine from Chinese black vinegar on antioxidant and hypolipidemia activities in HepG2 cells.	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20171101
Nrf2 Activation Is Required for Ligustrazine to Inhibit Hepatic Steatosis in Alcohol-Preferring Mice and Hepatocytes.	Toxicological sciences : an official journal of the Society of Toxicology 20170201
2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-κB, AP-1 and MAPK pathways in human proximal tubular cells.	Archives of toxicology 20160901
Nrf2 knockdown attenuates the ameliorative effects of ligustrazine on hepatic fibrosis by targeting hepatic stellate cell transdifferentiation.	Toxicology 20160715
Tetramethylpyrazine (TMP) protects against sodium arsenite-induced nephrotoxicity by suppressing ROS production, mitochondrial dysfunction, pro-inflammatory signaling pathways and programed cell death.	Archives of toxicology 20150701
Effect of dihydropyrazines on human hepatoma HepG2 cells: a comparative study using 2,3-dihydro-5,6-dimethylpyrazine and 3-hydro-2,2,5,6-tetramethylpyrazine.	The Journal of toxicological sciences 20140801
Ligustrazine attenuates elevated levels of indoxyl sulfate, kidney injury molecule-1 and clusterin in rats exposed to cadmium.	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20140101
Identification and characterization of a tetramethylpyrazine catabolic pathway in Rhodococcus jostii TMP1.	Applied and environmental microbiology 20130601
Ligustrazine attenuates oxidative stress-induced activation of hepatic stellate cells by interrupting platelet-derived growth factor-β receptor-mediated ERK and p38 pathways.	Toxicology and applied pharmacology 20121115
Development of ligustrazine-loaded lipid emulsion: formulation optimization, characterization and biodistribution.	International journal of pharmaceutics 20121101
Effect of Xiongbing compound on the pharmacokinetics and brain targeting of tetramethylpyrazine.	The Journal of pharmacy and pharmacology 20121101
A modified LC-MS/MS method for determination of tetramethylpyrazine in microdialysis samples and calibration of home-made linear probes.	Biomedical chromatography : BMC 20121001
[Effect of tetramethylpyrazine on the expression of macrophage migration inhibitory factor in acute spinal cord injury in rats].	Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20121001
Tetramethylpyrazine-mediated suppression of C6 gliomas involves inhibition of chemokine receptor CXCR4 expression.	Oncology reports 20120901
Characterization of cocoa liquors by GC-MS and LC-MS/MS: focus on alkylpyrazines and flavanols.	Journal of mass spectrometry : JMS 20120901
Effects of Ligustrazine on pulmonary damage in rats following scald injury.	Burns : journal of the International Society for Burn Injuries 20120801
Therapeutic effects of tetramethylpyrazine nitrone in rat ischemic stroke models.	Journal of neuroscience research 20120801
Effects of tetramethylpyrazine on cardiac function and mortality rate in septic rats.	Chinese journal of integrative medicine 20120801
Interaction of tetramethylpyrazine with two serum albumins by a hybrid spectroscopic method.	Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20120701
[Protective effect of Ligustrazine preconditioning on hepatic energy metabolism in ischemia/reperfusion injury of rat].	Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20120701
Novel multi-functional nitrones for treatment of ischemic stroke.	Bioorganic & medicinal chemistry 20120615
Tetramethylpyrazine reverses multidrug resistance in breast cancer cells through regulating the expression and function of P-glycoprotein.	Medical oncology (Northwood, London, England) 20120601
Microemulsion-based patch for transdermal delivery of huperzine A and ligustrazine phosphate in treatment of Alzheimer's disease.	Drug development and industrial pharmacy 20120601
Inhibition of cyclooxygenase-2 by tetramethylpyrazine and its effects on A549 cell invasion and metastasis.	International journal of oncology 20120601
Ligustrazine phosphate ethosomes for treatment of Alzheimer's disease, in vitro and in animal model studies.	AAPS PharmSciTech 20120601
Integrated investigation of lipidome and related signaling pathways uncovers molecular mechanisms of tetramethylpyrazine and butylidenephthalide protecting endothelial cells under oxidative stress.	Molecular bioSystems 20120601
[Effect of salvia miltiorrhiza and Ligustrazine injection on the early myocardial damage of patients with severe burn].	Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 20120601
Evaluation of antioxidant and immunity function of tetramethylpyrazine phosphate tablets in vivo.	Molecules (Basel, Switzerland) 20120508
Effects of ligustrazine on ureteral obstruction-induced renal tubulointerstitial fibrosis.	Phytotherapy research : PTR 20120501
Selective mGluR1 antagonist EMQMCM inhibits the kainate-induced excitotoxicity in primary neuronal cultures and in the rat hippocampus.	Neurotoxicity research 20120501
Ginsenoside-Rb1 and tetramethylpyrazine phosphate act synergistically to prevent dilated cardiomyopathy in cTnTR141W transgenic mice.	Journal of cardiovascular pharmacology 20120501
Ligustrazine derivatives. Part 4: design, synthesis, and biological evaluation of novel ligustrazine-based stilbene derivatives as potential cardiovascular agents.	Chemical biology & drug design 20120501
[Effects of ligustrazine on the mitochondrial structure and functions in the process myocardial hypertrophy].	Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20120501
[Garlicin ameliorated pressure overload induced myocardial fibrosis in rats through partial inhibiting TGF-beta1 mediated Smads signal].	Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20120501
[Effect of different compatibility of tetramethylpyrazine on its pharmacokinetics in vivo].	Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120501
Synthesis and biological evaluation of new ligustrazine derivatives as anti-tumor agents.	Molecules (Basel, Switzerland) 20120430
TMP prevents retinal neovascularization and imparts neuroprotection in an oxygen-induced retinopathy model.	Investigative ophthalmology & visual science 20120401
[The preparation and evaluation of tissue inducible nerve guide conduit].	Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20120401
Synergistic protective effect of astragaloside IV-tetramethylpyrazine against cerebral ischemic-reperfusion injury induced by transient focal ischemia.	Journal of ethnopharmacology 20120306
Preparation and pharmacokinetics in beagle dogs of once-a-day tetramethylpyrazine phosphate sustained-release pellets.	Drug development and industrial pharmacy 20120301
Tetramethylpyrazine attenuates PPAR-γ antagonist-deteriorated oxazolone-induced colitis in mice.	Molecular medicine reports 20120301
Tetramethylpyrazine potentiates arsenic trioxide activity against HL-60 cell lines.	Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20120301
Transcriptome profiling of heat-resistant strain Bacillus licheniformis CGMCC3962 producing Maotai flavor.	Journal of agricultural and food chemistry 20120227
Effects of Ligustrazine on pancreatic and renal damage after scald injury.	Burns : journal of the International Society for Burn Injuries 20120201
In pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization.	Purinergic signalling 20120201
Ligustrazine attenuates acute lung injury induced by blunt chest trauma.	Saudi medical journal 20120201
Protective effects of ligustrazine on TNF-α-induced endothelial dysfunction.	European journal of pharmacology 20120115
Ligustrazine injection for chronic pulmonary heart disease: a systematic review and meta-analysis.	Evidence-based complementary and alternative medicine : eCAM 20120101
Protective effect of ligustrazine against myocardial ischaemia reperfusion in rats: the role of endothelial nitric oxide synthase.	Clinical and experimental pharmacology & physiology 20120101
Six alkaloids inhibit secretion of IL-1α, TXB(2), ET-1 and E-selectin in LPS-induced endothelial cells.	Immunological investigations 20120101
Meta-analysis of the clinical effect of ligustrazine on diabetic nephropathy.	The American journal of Chinese medicine 20120101
Peripheral arterial and venous response to tilt test after a 60-day bedrest with and without countermeasures (ES-IBREP).	PloS one 20120101
Chinese herb and formulas for promoting blood circulation and removing blood stasis and antiplatelet therapies.	Evidence-based complementary and alternative medicine : eCAM 20120101
Systematic Review of Chinese Herbal Medicines for Preventing in-Stent Coronary Restenosis after Percutaneous Coronary Intervention.	Evidence-based complementary and alternative medicine : eCAM 20120101
The 'brain-skin connection' in protein misfolding and amyloid deposits: embryological, pathophysiological, and therapeutic common grounds?	Frontiers in neurology 20120101
Current situation and perspectives of clinical study in integrative medicine in china.	Evidence-based complementary and alternative medicine : eCAM 20120101
Ligustrazine attenuates myocardial ischemia reperfusion injury in rats by activating the phosphatidylinositol 3-kinase/Akt pathway.	Annals of clinical and laboratory science 20120101
Outcome measures of chinese herbal medicine for coronary heart disease: an overview of systematic reviews.	Evidence-based complementary and alternative medicine : eCAM 20120101
TREM-1 Promotes Pancreatitis-Associated Intestinal Barrier Dysfunction.	Gastroenterology research and practice 20120101
Understanding the mechanism of hepatic fibrosis and potential therapeutic approaches.	Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association 20120101
Preparation of natural borneol/2-hydroxypropyl-β-cyclodextrin inclusion complex and its effect on the absorption of tetramethylpyrazine phosphate in mouse.	Chemical & pharmaceutical bulletin 20120101
Traditional Japanese herbal (kampo) medicines and treatment of ocular diseases: a review.	The American journal of Chinese medicine 20120101
Protective effects of Ligustrazine, Kakonein and Panax Notoginsenoside on the small intestine and immune organs of rats with severe acute pancreatitis.	Hepatobiliary & pancreatic diseases international : HBPD INT 20111201
Ligustrazine derivatives. Part 5: design, synthesis and biological evaluation of novel ligustrazinyloxy-cinnamic acid derivatives as potent cardiovascular agents.	European journal of medicinal chemistry 20111101
[Molecular mechanism of tetramethylpyrazine to induce human promyelocytic HL-60 leukemia cells differentiation].	Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20111101
Protective effect of tetramethylpyrazine isolated from Ligusticum chuanxiong on nephropathy in rats with streptozotocin-induced diabetes.	Phytomedicine : international journal of phytotherapy and phytopharmacology 20111015
Tetramethylpyrazine inhibits migration of SKOV3 human ovarian carcinoma cells and decreases the expression of interleukin-8 via the ERK1/2, p38 and AP-1 signaling pathways.	Oncology reports 20110901
Ligustrazine inhibits lipopolysaccharide-induced proliferation by affecting P27, Bcl-2 expression in rat mesangial cells.	European journal of pharmacology 20110831
Ligustrazine improves atherosclerosis in rat via attenuation of oxidative stress.	Pharmaceutical biology 20110801
[Inhalation of aerosolized perfluorocarbon combined with tetramethylpyrazine ameliorates hemodynamics and pulmonary histopathology in a porcine model of acute lung injury].	Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20110801
Ligustrazine formation in Zhenjiang aromatic vinegar: changes during fermentation and storing process.	Journal of the science of food and agriculture 20110701
Tetramethylpyrazine protects spinal cord and reduces inflammation in a rat model of spinal cord ischemia-reperfusion injury.	Journal of vascular surgery 20110701
Protective effects and mechanism of tetramethylpyrazine against lens opacification induced by sodium selenite in rats.	Experimental eye research 20110701
Chuanxiongzine-astragaloside IV decreases IL-1β and Caspase-3 gene expressions in rat brain damaged by cerebral ischemia/reperfusion: a study of real-time quantitative PCR assay.	Sheng li xue bao : [Acta physiologica Sinica] 20110625
Volatile analysis of ground almonds contaminated with naturally occurring fungi.	Journal of agricultural and food chemistry 20110608
Effect of ligustrazine on mice model of hepatic veno-occlusive disease induced by Gynura segetum.	Journal of gastroenterology and hepatology 20110601
Pharmacokinetic study of a novel stroke therapeutic, 2-[[(1,1-dimethylethyl)oxidoimino]methyl]-3,5,6-trimethylpyrazine, by a simple HPLC-UV method in rats.	European journal of drug metabolism and pharmacokinetics 20110601
A comprehensive evaluation of the toxicology of cigarette ingredients: heterocyclic nitrogen compounds.	Inhalation toxicology 20110601
(E,E,E,E)-2,3,5,6-Tetra-kis{2-[4-(dimethyl-amino)-phen-yl]ethen-yl}pyrazine.	Acta crystallographica. Section E, Structure reports online 20110601
Transcriptome analysis of the effects of gomisin a on the recovery of carbon tetrachloride-induced damage in rat liver.	Laboratory animal research 20110601
[Effect of tetramethylpyrazine on JAK-STAT signal transduction in cardiomyocyte hypertrophy].	Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20110501
Tetramethylpyrazine protects palmitate-induced oxidative damage and mitochondrial dysfunction in C2C12 myotubes.	Life sciences 20110425
The protective mechanism of ligustrazine against renal ischemia/reperfusion injury.	The Journal of surgical research 20110401
Comparison of fermented soybean paste (Doenjang) prepared by different methods based on profiling of volatile compounds.	Journal of food science 20110401
Monoclinic polymorph of 2,5-bis[4-(dimethyl-amino)-styr-yl]-3,6-dimethyl-pyrazine.	Acta crystallographica. Section E, Structure reports online 20110401
Additive effect of tetramethylpyrazine and deferoxamine in the treatment of spinal cord injury caused by aortic cross-clamping in rats.	Spinal cord 20110201
3-(4-Hy-droxy-3-meth-oxy-phen-yl)acrylic acid-2,3,5,6-tetra-methyl-pyrazine (2/1).	Acta crystallographica. Section E, Structure reports online 20110201
An antioxidant phytotherapy to rescue neuronal oxidative stress.	Evidence-based complementary and alternative medicine : eCAM 20110101
Mediation of Endogenous β-Endorphin in the Plasma Glucose-Lowering Action of Herbal Products Observed in Type 1-Like Diabetic Rats.	Evidence-based complementary and alternative medicine : eCAM 20110101
Antihypertension Induced by Tanshinone IIA Isolated from the Roots of Salvia miltiorrhiza.	Evidence-based complementary and alternative medicine : eCAM 20110101
Kainic acid-induced neurodegenerative model: potentials and limitations.	Journal of biomedicine & biotechnology 20110101
Pathophysiology, treatment, and animal and cellular models of human ischemic stroke.	Molecular neurodegeneration 20110101
[Protective effect of valsartan or/and ligustrazine on hippocampal neuronal loss in rats with vascular dementia].	Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20110101
Differential proteomic analysis of platelets suggested possible signal cascades network in platelets treated with salvianolic acid B.	PloS one 20110101
Tetramethylpyrazine inhibits hypoxia-induced pulmonary vascular leakage in rats via the ROS-HIF-VEGF pathway.	Pharmacology 20110101
Preparation of a ligustrazine ethosome patch and its evaluation in vitro and in vivo.	International journal of nanomedicine 20110101
Attenuating effect of pretreatment with Yiqifumai on lipopolysaccharide-induced intestine injury and survival rate in rat.	Journal of inflammation (London, England) 20110101
Effect of Guanabenz on Rat AMD Models and Rabbit Choroidal Blood Flow.	The open ophthalmology journal 20110101
Effect of Ligusticum wallichii aqueous extract on oxidative injury and immunity activity in myocardial ischemic reperfusion rats.	International journal of molecular sciences 20110101
Anti-inflammatory effects of Chinese medicinal herbs on cerebral ischemia.	Chinese medicine 20110101
Pharmacokinetics of ligustrazine ethosome patch in rats and anti-myocardial ischemia and anti-ischemic reperfusion injury effect.	International journal of nanomedicine 20110101
Mechanisms underlying purinergic P2X3 receptor-mediated mechanical allodynia induced in diabetic rats.	Molecular pain 20110101
Role of Bone Morphogenetic Proteins-7 (BMP-7) in the Renal Improvement Effect of DangGui (Angelica sinensis) in Type-1 Diabetic Rats.	Evidence-based complementary and alternative medicine : eCAM 20110101
Microemulsion-based novel transdermal delivery system of tetramethylpyrazine: preparation and evaluation in vitro and in vivo.	International journal of nanomedicine 20110101
Preparation and evaluation of quercetin-loaded lecithin-chitosan nanoparticles for topical delivery.	International journal of nanomedicine 20110101
Evaluation of the Possible Mechanisms of Antihypertensive Activity of Loranthus micranthus: An African Mistletoe.	Biochemistry research international 20110101
The importance of the stem cell marker prominin-1/CD133 in the uptake of transferrin and in iron metabolism in human colon cancer Caco-2 cells.	PloS one 20110101
Enhanced transdermal delivery of evodiamine and rutaecarpine using microemulsion.	International journal of nanomedicine 20110101
A review on mucoadhesive polymer used in nasal drug delivery system.	Journal of advanced pharmaceutical technology & research 20110101
Cytoprotective effects of CSTMP, a novel stilbene derivative, against H2O2-induced oxidative stress in human endothelial cells.	Pharmacological reports : PR 20110101
P2X receptors and modulation of pain transmission: focus on effects of drugs and compounds used in traditional Chinese medicine.	Neurochemistry international 20101201
Effects of tetramethylpyrazine on nitric oxide/cGMP signaling after cerebral vasospasm in rabbits.	Brain research 20101118
The protective effect of tetramethylpyrazine on cartilage explants and chondrocytes.	Journal of ethnopharmacology 20101111
Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples.	Archives of toxicology 20101101
Synthesis of novel ligustrazine derivatives as NA+/H+ exchange inhibitors.	Chemistry & biodiversity 20101101
Ligustrazine as a salvage agent for patients with relapsed or refractory non-Hodgkin's lymphoma.	Chinese medical journal 20101101
Protective effects of ligustrazine, kakonein and Panax notoginsenosides on multiple organs in rats with severe acute pancreatitis.	Methods and findings in experimental and clinical pharmacology 20101101
Impacts of bicyclo-monoterpene enhancers on transdermal delivery of ligustrazine.	Yao xue xue bao = Acta pharmaceutica Sinica 20101101
A feeding strategy for tetramethylpyrazine production by Bacillus subtilis based on the stimulating effect of ammonium phosphate.	Bioprocess and biosystems engineering 20101001
Coadministration of huperzine A and ligustrazine phosphate effectively reverses scopolamine-induced amnesia in rats.	Pharmacology, biochemistry, and behavior 20101001
TMPDP, a tetramethylpyrazine derivative, protects vascular endothelial cells from oxidation damage by hydrogen peroxide.	Die Pharmazie 20101001
[Simultaneous determination of five effective components in Rhizoma Chuanxiong by RP-HPLC].	Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101001
[Permeability of blood-brain barrier oxygen-glucose deprivation induced by tetramethylpyrazine-puerarin in vitro].	Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101001
[Pharmacokinetics studies on tetramethylpyrazine by intravenous administration in rats].	Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20101001
[Inhibitory effect of TBN on platelet aggregation in rabbit].	Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100901
Volatile composition and sensory analysis of Italian gianduja torrone.	Journal of the science of food and agriculture 20100815
Production of tetramethylpyrazine by batch culture of Bacillus subtilis with optimal pH control strategy.	Journal of industrial microbiology & biotechnology 20100801
[Effect of ligustrazine hydrocklorde on induced alcoholic fatty liver in vitro].	Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20100801
[Determination of plasma protein binding rate of tetramethylpyrazine phosphate by ultrafiltration].	Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100801
Alleviation of CCl4-induced cirrhosis in rats by tetramethylpyrazine is associated with downregulation of leptin and TGF-beta1 pathway.	Drug and chemical toxicology 20100701
[Perioperative intervention of tetramethylpyrazine on free skin flap transplantation].	Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20100701
Tetramethylpyrazine inhibits production of nitric oxide and inducible nitric oxide synthase in lipopolysaccharide-induced N9 microglial cells through blockade of MAPK and PI3K/Akt signaling pathways, and suppression of intracellular reactive oxygen species.	Journal of ethnopharmacology 20100616
Neuroprotection and enhanced neurogenesis by tetramethylpyrazine in adult rat brain after focal ischemia.	Neurological research 20100601
Tetramethylpyrazine promotes proliferation and differentiation of neural stem cells from rat brain in hypoxic condition via mitogen-activated protein kinases pathway in vitro.	Neuroscience letters 20100419
[Comparative study on pharmacokinetics of tetramethylpyrazine, ferulic acid and their compatibility].	Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100401
[Effects of tetramethylpyrazine on fractalkine and tumor necrosis factor-alpha expression in patients with chronic pulmonary heart disease].	Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20100401
Chuanxiongzine relaxes isolated corpus cavernosum strips and raises intracavernous pressure in rabbits.	International journal of impotence research 20100301
Protective action of tetramethylpyrazine phosphate against dilated cardiomyopathy in cTnT(R141W) transgenic mice.	Acta pharmacologica Sinica 20100301
Stabilization of mitochondrial function by tetramethylpyrazine protects against kainate-induced oxidative lesions in the rat hippocampus.	Free radical biology & medicine 20100215
Effect of tetramethylpyrazine on DRG neuron P2X3 receptor involved in transmitting pain after burn.	Burns : journal of the International Society for Burn Injuries 20100201
High-yield fermentative preparation of tetramethylpyrazine by Bacillus sp. using an endogenous precursor approach.	Journal of industrial microbiology & biotechnology 20100201
[Effect of Ligusticum and its two main components on muscle atrophy in a hind limb unloaded rat model].	Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20100201
The effect of tetramethylpyrazine on hydrogen peroxide-induced oxidative damage in human umbilical vein endothelial cells.	Basic & clinical pharmacology & toxicology 20100101
Inhibition of tetramethylpyrazine on P-gp, MRP2, MRP3 and MRP5 in multidrug resistant human hepatocellular carcinoma cells.	Oncology reports 20100101
Mechanism of tetramethylpyrazine analogue CXC195 inhibition of hydrogen peroxide-induced apoptosis in human endothelial cells.	Biological & pharmaceutical bulletin 20100101
Alkylpyrazines and other volatiles in cocoa liquors at pH 5 to 8, by Selected Ion Flow Tube-Mass Spectrometry (SIFT-MS).	Journal of food science 20100101
Stem cell-based neuroprotective and neurorestorative strategies.	International journal of molecular sciences 20100101
Circumvention of multi-drug resistance of cancer cells by Chinese herbal medicines.	Chinese medicine 20100101
Endothelium-independent vasorelaxation by Ligusticum wallichii in isolated rat aorta: comparison of a butanolic fraction and tetramethylpyrazine, the main active component of Ligusticum wallichii.	Biological & pharmaceutical bulletin 20100101
Effect of salvianolic acid B and paeonol on blood lipid metabolism and hemorrheology in myocardial ischemia rabbits induced by pituitruin.	International journal of molecular sciences 20100101
Herb network construction and co-module analysis for uncovering the combination rule of traditional Chinese herbal formulae.	BMC bioinformatics 20100101
Effect of Tetramethylpyrazine on RPE degeneration, choroidal blood flow and oxidative stress of RPE cells.	International journal of ophthalmology 20100101
Traditional Chinese medicine Bak Foong Pills alters uterine quiescence - possible role in alleviation of dysmenorrhoeal symptoms.	Cell biology international 20091201
[Relationship of tetramethylpyrazine on expression of vascular endothelial growth factor and development of adjuvant-induced arthritis in rats].	Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20091101
[Studies on protection and mechanism of tetramethylpyrazine on myocardial injury of rats with DHF].	Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20091101
Syntheses, structures, and photoluminescence of a series of silver(I) sulfonates with pyrazine derivatives.	Dalton transactions (Cambridge, England : 2003) 20091014
[Artificial neural network parameters optimization software and its application in the design of sustained release tablets].	Yao xue xue bao = Acta pharmaceutica Sinica 20091001
Formation and identification of trimethylimidazole during tetramethylpyrazine production from glucose by Bacillus strains.	Biotechnology letters 20090901
Ligustrazine inhibits B16F10 melanoma metastasis and suppresses angiogenesis induced by Vascular Endothelial Growth Factor.	Biochemical and biophysical research communications 20090821
Tetramethylpyrazine suppresses interleukin-8 expression in LPS-stimulated human umbilical vein endothelial cell by blocking ERK, p38 and nulear factor-kappaB signaling pathways.	Journal of ethnopharmacology 20090817
[Protective effects of tetramethylpyrazine on rat myocardial cells infected by Coxsackie virus B3 and its signal transduction mechanism].	Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20090801
[Effects of tetramethylpyrazine on thrombin-induced tissue factor expression in vascular endothelial cells].	Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20090801
[The enhancing effect of borneol on the absorption of tetramethylpyrazine].	Yao xue xue bao = Acta pharmaceutica Sinica 20090801
Development of a GC x GC-TOFMS method using SPME to determine volatile compounds in cacao beans.	Journal of separation science 20090701
[Effect of tetramethylpyrazine added to vitrification solution on peripheral nerve allografts regeneration].	Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery 20090701
Brain pharmacokinetics of tetramethylpyrazine after intranasal and intravenous administration in awake rats.	International journal of pharmaceutics 20090622
Comparative protective effect of N-acetyl cysteine and tetramethylpyrazine in rats with gentamicin nephrotoxicity.	Journal of applied toxicology : JAT 20090501
Ligustrazine derivatives. Part 3: Design, synthesis and evaluation of novel acylpiperazinyl derivatives as potential cerebrocardiac vascular agents.	Bioorganic & medicinal chemistry 20090415
In reference to Fu et al. (neuro-Oncology 2008:10139-152).	Neuro-oncology 20090401
Antioxidative effect of the herbal remedy Qin Huo Yi Hao and its active component tetramethylpyrazine on high glucose-treated endothelial cells.	Life sciences 20090327
Antioxidation and anti-inflammation by haem oxygenase-1 contribute to protection by tetramethylpyrazine against gentamicin-induced apoptosis in murine renal tubular cells.	Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20090301
Protective effect of tetraethyl pyrazine against focal cerebral ischemia/reperfusion injury in rats: therapeutic time window and its mechanism.	Thrombosis research 20090301
[Effects of tetramethylpyrazine on angiotensin II -induced proliferation and type I collagen synthesis of rat cardiac fibroblasts].	Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20090301
Hydrogen sulfide protects from intestinal ischaemia-reperfusion injury in rats.	The Journal of pharmacy and pharmacology 20090201
Therapeutic time window and mechanism of tetramethylpyrazine on transient focal cerebral ischemia/reperfusion injury in rats.	Neuroscience letters 20090102
[Effects of ligustrazine injection on high glucose-induced type I collagen, matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 expressions in human peritoneal mesothelial cells in vitro].	Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20090101
Atorvastatin ameliorates cerebral vasospasm and early brain injury after subarachnoid hemorrhage and inhibits caspase-dependent apoptosis pathway.	BMC neuroscience 20090101
[Effect of tetramethylpyrazine on expression of Smad7 and SnoN in rats with UUO].	Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090101
Chinese medicines as a resource for liver fibrosis treatment.	Chinese medicine 20090101
Neurological and neurobehavioral assessment of experimental subarachnoid hemorrhage.	BMC neuroscience 20090101
Purinergic mechanosensory transduction and visceral pain.	Molecular pain 20090101
Protective effect of chuanxiongzine-puerarin in a rat model of transient middle cerebral artery occlusion-induced focal cerebral ischemia.	Nuclear medicine communications 20081201
[The influence of JNK inhibitor on hemodynamics after ischemia/reperfusion injury to the heart in rats].	Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20081201
Forty-six cases of vertebrobasilar insufficiency treated by acupuncture plus intravenous infusion of ligustrazine.	Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 20081201
Effect of chitosan structure properties and molecular weight on the intranasal absorption of tetramethylpyrazine phosphate in rats.	European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20081101
[Effect of ligustrazine on expression of RhoA mRNA, ROCK-II protein in the lung and airway inflammation of allergic asthma model mice].	Zhonghua er ke za zhi = Chinese journal of pediatrics 20081101
[Regulatory effect of ligustrazine and Radix astragalus on RANTES and receptor CCR5 expression in the genesis and development process of endometriosis].	Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20081101
[Effects of ligustrazine on extracellular acetylcholine levels in rat brain dialysate].	Yao xue xue bao = Acta pharmaceutica Sinica 20081101
Ferulic acid, but not tetramethylpyrazine, significantly attenuates retinal ischemia/reperfusion-induced alterations by acting as a hydroxyl radical scavenger.	Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20081001
Antioxidative and thrombolytic TMP nitrone for treatment of ischemic stroke.	Bioorganic & medicinal chemistry 20081001
Effect of tetramethylpyrazine on primary afferent transmission mediated by P2X3 receptor in neuropathic pain states.	Brain research bulletin 20080905
Effect of ligustrazine injection on levels of interleukin-4 and interferon-gamma in patients with bronchial asthma.	Chinese journal of integrative medicine 20080901
[The efficacy of tetramethylpyrazine-eluting stents on inhibiting neointima formation in porcine coronary arteries].	Zhonghua xin xue guan bing za zhi 20080901
Anti-apoptotic and neuroprotective effects of Tetramethylpyrazine following subarachnoid hemorrhage in rats.	Autonomic neuroscience : basic & clinical 20080818
[Mechanism of ligustrazine promoting hematopoietic reconstitution in syngenic bone marrow transplanted mice].	Zhongguo shi yan xue ye xue za zhi 20080801
[Tetramethylpyrazine accelerated spinal cord repair through regulation of caspase-3 and neurofilament protein expression: an acute spinal cord injury model in rats].	Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20080801
[Determination and fingerprint analysis of tetramethylpyrazine and ferulic acid in Ligusticum chuanxiong].	Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080801
Amelioration of cisplatin-induced nephrotoxicity in rats by tetramethylpyrazine, a major constituent of the Chinese herb Ligusticum wallichi.	Experimental biology and medicine (Maywood, N.J.) 20080701
[Effect of acupuncture on target action of ligustrazine in treatment of toxic deafness induced by gentamicin in guinea pigs].	Zhongguo zhen jiu = Chinese acupuncture & moxibustion 20080701
Protective effects of tetramethylpyrazine on rat retinal cell cultures.	Neurochemistry international 20080501
[Effects of tetramethylpyrazine on the scores of the water maze and the long-term potentiation of hippocampus in epileptic Sprague Dawley rats].	Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20080501
Preparation of molecularly imprinted adsorptive resin for trapping of ligustrazine from the traditional Chinese herb Ligusticum chuanxiong Hort.	Analytica chimica acta 20080407
Tetramethylpyrazine inhibits activities of glioma cells and glutamate neuro-excitotoxicity: potential therapeutic application for treatment of gliomas.	Neuro-oncology 20080401
[Impacts of tetramethylpyrazine on BDNF, bFGF expression and neuron-protection in severe brain injury tissue of rat].	Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20080301
[Effects of tetramethylpyrazine on endothelin and nitric oxide contents in plasma and cerebrospinal fluid after subarachnoid hemorrhage].	Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20080301
Biocompatibility of tetramethylpyrazine-eluting stents in normal porcine coronary arteries.	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20080201
[Effect of puerarin and ligustrazine on cultured hippocampal neurons injury induced by Abeta25-35].	Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080201
[Influence of borneol on nasal absorption of Ligustrazinee].	Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080201
[Optimization of ligustrazine phosphate thermosensitive gel formulation by central composite design-response surface methodology].	Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080201
Protective effect of tetramethylpyrazine and salvianolic acid B on apoptosis of rat cerebral microvascular endothelial cell under high shear stress.	Clinical hemorheology and microcirculation 20080101
A simple gas chromatographic method for the simultaneous determination and pharmacokinetic study of tetramethylpyrazine phosphate and borneol in mouse plasma and brain tissue after oral administration of the fufang tetramethylpyrazine phosphate tablets.	Journal of chromatographic science 20080101
Suppression of blood lipid concentrations by volatile Maillard reaction products.	Nutrition (Burbank, Los Angeles County, Calif.) 20080101
Effect of ligustrazine on chronic allograft nephropathy in rats.	Transplantation proceedings 20071201
[Effect of tetramethylpyrazine on platelet activation and vascular endothelial function in patients with acute coronary syndrome undergoing percutaneous coronary intervention].	Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20071201
[Ligustrazine and cimetidine therapy for the prevention of Henoch-Schonlein purpura nephritis in children: a follow-up study of 380 cases].	Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20071001
Muscle composition after 14-day hindlimb unloading in rats: effects of two herbal compounds.	Aviation, space, and environmental medicine 20071001
Pharmacological activity of cardiovascular agents from herbal medicine.	Cardiovascular & hematological agents in medicinal chemistry 20071001
[Effects of acupoint-embedding of medicinal thread and electroacupuncture on contents of TNF-alpha and IL-6 of hippocampus tissue in rats with focal cerebral ischemia-reperfusion injury].	Zhen ci yan jiu = Acupuncture research 20071001
Effects of cinnamene enhancers on transdermal delivery of ligustrazine hydrochloride.	European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20070901
[Aqueous humor penetration of ligustrazine hydrochloride eye drops after topical administration in rabbit eyes].	Yan ke xue bao = Eye science 20070901
Attenuation of streptomycin ototoxicity by tetramethylpyrazine and its effect on K⁺ channels in the outer hair cells of guinea pig cochlea.	Sheng li xue bao : [Acta physiologica Sinica] 20070825
Tetramethylpyrazine-eluting stents prevented in-stent restenosis in a porcine model.	Journal of cardiovascular pharmacology 20070801
Quantitative study of the drug efflux kinetics from sensitive and MDR human breast cancer cells.	Biochimica et biophysica acta 20070701
[Effects of tetramethylpyrazine on brain oxidative damage induced by intracerebral perfusion of L-DOPA in rats with Parkinson's disease].	Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20070701
Tetramethylpyrazine inhibits agiontensin II-induced nuclear factor-kappaB activation and bone morphogenetic protein-2 downregulation in rat vascular smooth muscle cells.	Sheng li xue bao : [Acta physiologica Sinica] 20070625
Supramolecular synthon polymorphism in 2 : 1 co-crystal of 4-hydroxybenzoic acid and 2,3,5,6-tetramethylpyrazine.	Chemical communications (Cambridge, England) 20070621
The enhancing effect of synthetical borneol on the absorption of tetramethylpyrazine phosphate in mouse.	International journal of pharmaceutics 20070607
Protective effect of ligustrazine on accelerated anti-glomerular basement membrane antibody nephritis in rats is based on its antioxidant properties.	European journal of pharmacology 20070601
Delayed protection of tetramethylpyrazine on neonatal rat cardiomyocytes subjected to anoxia-reoxygenation injury.	Basic & clinical pharmacology & toxicology 20070601
[Effect of ligustrazine on nNOS expression and neuranagenesis in adult rats after cerebral ischemia-reperfusion injury].	Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20070601
[Relationship between cardiomyocyte protein synthesis and cell viability].	Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20070601
[Effect of ligustrazine on cell proliferation in subventricular zone in rat brain with focal cerebral ischemia-reperfusion injury].	Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20070601
Design, synthesis, and biological activities of novel Ligustrazine derivatives.	Bioorganic & medicinal chemistry 20070515
Ligustrazine attenuates acute myocardium injury after thermal trauma.	Burns : journal of the International Society for Burn Injuries 20070501
Neuroprotective effects of tetramethylpyrazine on hydrogen peroxide-induced apoptosis in PC12 cells.	Cell biology international 20070501
[Effect of ligustrazine on migration of neuronal precursors after focal cerebral ischemia in adult rats].	Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20070501
[Effect of ligustrazine and L-arginine on function of mitochondria in myocardium after ischemia/reperfusion injury of myocardium in rabbits].	Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20070501
Ligustrazine alleviates gastric mucosal injury in a rat model of acute necrotizing pancreatitis.	Hepatobiliary & pancreatic diseases international : HBPD INT 20070401
Tetramethylpyrazine protects rat renal tubular cell apoptosis induced by gentamicin.	Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20070301
Tetramethylpyrazine suppresses HIF-1alpha, TNF-alpha, and activated caspase-3 expression in middle cerebral artery occlusion-induced brain ischemia in rats.	Acta pharmacologica Sinica 20070301
[Establishment of oxygen and glucose deprive model of in vitro cultured hippocampal neuron and effect of ligustrazine on intracellular Ca+ level in model neurons].	Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20070301
Proteomic analysis of the effects of tetramethylpyrazine on irradiated QXMSC1 cells.	Biological & pharmaceutical bulletin 20070201
[Effect of ligustrazine on expression of Fas/FasL in pulmonary injury induced by ischemia/reperfusion in rabbits].	Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20070201
The cardioprotective effect of isosteviol on rats with heart ischemia-reperfusion injury.	Life sciences 20070102
Effect of tetramethylpyrazine on rat experimental choroidal neovascularization in vivo and endothelial cell cultures in vitro.	Current eye research 20070101
Effect and mechanism of ligustrazine on Th1/Th2 cytokines in a rat asthma model.	The American journal of Chinese medicine 20070101
Tetramethylpyrazine inhibits angiotensin II-increased NAD(P)H oxidase activity and subsequent proliferation in rat aortic smooth muscle cells.	The American journal of Chinese medicine 20070101
Ligustrazine alleviates acute renal injury in a rat model of acute necrotizing pancreatitis.	World journal of gastroenterology 20061221
Tetramethylpyrazine production from glucose by a newly isolated Bacillus mutant.	Applied microbiology and biotechnology 20061201
[Study on metabolism of tetramethylpyrazine in system of rat liver microsomes].	Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061201
X-ray diffraction and inelastic neutron scattering study of 1:1 tetramethylpyrazine chloranilic acid complex: temperature, isotope, and pressure effects.	The Journal of chemical physics 20061121
Ligustrazine alleviates acute lung injury in a rat model of acute necrotizing pancreatitis.	Hepatobiliary & pancreatic diseases international : HBPD INT 20061101
[The effect of ligustrazine on cells proliferation in cortex and striatum after focal cerebral ischemia in adult rats].	Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20061101
Preventive effect of tetramethylpyrazine on intestinal mucosal injury in rats with acute necrotizing pancreatitis.	World journal of gastroenterology 20061021
[Effects of ligustrazine on hippocampal dentate gyrus cell proliferation after focal cerebral ischemia in adult rats].	Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20061001
[Effect of ligustrazine on the expression of bFGF in bone marrow stromal cells of mice after BMT].	Zhongguo shi yan xue ye xue za zhi 20061001
[Effects of tetramethylpyrazine on expression of vascular endothelial growth factor and hypoxia-induced factor-1alpha by rat peritoneal macrophages].	Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061001
Tetramethylpyrazine induces heme oxygenase-1 expression and attenuates myocardial ischemia/reperfusion injury in rats.	Journal of biomedical science 20060901
Gateways to clinical trials.	Methods and findings in experimental and clinical pharmacology 20060901
[Effect of ligustrazine on cell proliferation in subventricular zone of lateral cerebral ventricle after adult rat suffering from focal cerebral ischemia].	Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20060901
[The effect of tetramethylpyrazine on the pharmacokinetics of intragastrically administered cyclosporine A in rats].	Yao xue xue bao = Acta pharmaceutica Sinica 20060901
[Effects of ligustrazine injection on lymph circulation in rats with acute microcirculation disturbance].	Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20060901
Effect of citric acid and glycine addition on acrylamide and flavor in a potato model system.	Journal of agricultural and food chemistry 20060809
Tetramethylpyrazine attenuates adriamycin-induced apoptotic injury in rat renal tubular cells NRK-52E.	Planta medica 20060801
[Therapeutic effects of intraarticular injection of ligustrazine on knee osteoarthritis].	Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20060801
[Inhibition of extracts from 17 Chinese herbs on periodontal pathogenic microbes].	Shanghai kou qiang yi xue = Shanghai journal of stomatology 20060801
[Investigation of the in vivo desintegration and transit behavior of tetramethylpyrazine phosphate pulsincap capsule in the gastrointestinal tract of dogs by gamma scintigraphy].	Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20060801
[Effects of D-limonene and L-limonene on transdermal absorption of ligustrazine hydrochloride].	Yao xue xue bao = Acta pharmaceutica Sinica 20060801
[Effect of ligustrazine, synthetic borneol on lasting time of ciliary movement].	Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20060801
[The effects of tetramethylpyrazine on lung injury induced by brain ischemia/reperfusion].	Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20060801
Effects of four Si-Wu-Tang's constituents and their combination on irradiated mice.	Biological & pharmaceutical bulletin 20060701
[Effect of Ligustrazine on type I, III collagen synthesis in lung tissue of silica-treated rat].	Wei sheng yan jiu = Journal of hygiene research 20060701
Simultaneous determination of Gastrodin and Ligustrazine hydrochloride in dog plasma by gradient high-performance liquid chromatography.	Journal of pharmaceutical and biomedical analysis 20060616
Involvement of intracellular and extracellular Ca2+ in tetramethylpyrazine-induced colonic anion secretion.	Cell biology international 20060601
Effect of Ligustrazine on liver injury after burn trauma.	Burns : journal of the International Society for Burn Injuries 20060501
Microsphere-based protease assays and screening application for lethal factor and factor Xa.	Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Inhibitory mechanisms of tetramethylpyrazine in middle cerebral artery occlusion (MCAO)-induced focal cerebral ischemia in rats.	Planta medica 20060401
Low frequency internal modes of 1,2,4,5-tetramethylbenzene, tetramethylpyrazine and tetramethyl-1,4-benzoquinone INS, Raman, infrared and theoretical DFT studies.	Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20060301
[The effects of tetramethylpyrazine in combination with rhein on proliferation and apoptosis in human liver cell L-02 induced by TGFb1 and TG].	Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20060301
[Protective effect of ligustrazine and propofol on peri-operational liver ischemia-reperfusion injury].	Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20060301
Ligustrazine inhibits high voltage-gated Ca(2+) and TTX-resistant Na(+) channels of primary sensory neuron and thermal nociception in the rat: a study on peripheral mechanism.	Neuroscience bulletin 20060301
[Effects of tetramethylpyrazine on large-conductance Ca²⁺-activated potassium channels in porcine coronary artery smooth muscle cells].	Sheng li xue bao : [Acta physiologica Sinica] 20060225
Neuroprotection by tetramethylpyrazine against ischemic brain injury in rats.	Neurochemistry international 20060201
[Effects of tetramethylpyrazine on fibrosis of atrial tissue and atrial fibrillation in a canine model of congestive heart failure induced by ventricular tachypacing].	Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20060101
Simple high-performance liquid chromatographic method for the determination of tetramethylpyrazine phosphate in very small volumes of dog plasma: application to a pharmacokinetic study.	Journal of chromatographic science 20060101
[Interferential effect of ligustrazine injection on lymph circulation during the recovery of hemorrhagic shock in rats].	Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20060101
Anti-apoptotic and neuroprotective effects of Tetramethylpyrazine following spinal cord ischemia in rabbits.	BMC neuroscience 20060101
Effects of enantiomer and isomer permeation enhancers on transdermal delivery of ligustrazine hydrochloride.	Pharmaceutical development and technology 20060101
Preclinical and clinical examinations of Salvia miltiorrhiza and its tanshinones in ischemic conditions.	Chinese medicine 20060101
The underlying cellular mechanism in the effect of tetramethylpyrazine on the anion secretion of colonic mucosa.	The Japanese journal of physiology 20051201
[Effect of ligustrazine on the expression and activity of heme oxygenase-1 in the pulmonary ischemia/reperfusion injury in rabbits].	Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20051101
Tetramethylpyrazine downregulates angiotensin II-induced endothelin-1 gene expression in vascular endothelial cells.	Clinical and experimental pharmacology & physiology 20051001
Role of cGMP signals in tetramethylpyrazine induced relaxation of the isolated rat aortic strip.	Life sciences 20050812
[Effects of Ligustrazine and Radix Astragali on activities of myosin adenosine triphosphatase of soleus muscle and muscle atrophy in tail-suspended rats].	Hang tian yi xue yu yi xue gong cheng = Space medicine & medical engineering 20050801
[Protective effects of ligustrazine against photoreceptor cell injury induced by N-methyl-N-nitrosourea and its mechanism].	Yao xue xue bao = Acta pharmaceutica Sinica 20050801
Tetramethylpyrazine stimulates cystic fibrosis transmembrane conductance regulator-mediated anion secretion in distal colon of rodents.	World journal of gastroenterology 20050721
Tetramethylpyrazine protected photoreceptor cells of rats by modulating nuclear translocation of NF-kappaB.	Acta pharmacologica Sinica 20050701
Inhibition of cyclic strain-induced endothelin-1 secretion by tetramethylpyrazine.	Clinical and experimental pharmacology & physiology 20050701
[Protective effect of tetramethylpyrazine on the respiratory inhibition induced by hypoxia in rats].	Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20050701
Ligustrazine attenuates acute lung injury after burn trauma.	Burns : journal of the International Society for Burn Injuries 20050601
[Determination of ligustrazine in human plasma by high performance liquid chromatography with solid-phase extraction].	Se pu = Chinese journal of chromatography 20050501
[Effect of tetramethylpyrazine on the responses of respiration and expression of nNOS in brainstem to hypoxia in rats].	Sheng li xue bao : [Acta physiologica Sinica] 20050425
Tetramethylpyrazine inhibits ATP-activated currents in rat dorsal root ganglion neurons.	Brain research 20050408
[Effect of danshensu and ligustrazine on related genes of myocardial hypertrophy induced by angiotensin II].	Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20050401
Activation of apical CFTR and basolateral Ca(2+)-activated K+ channels by tetramethylpyrazine in Caco-2 cell line.	European journal of pharmacology 20050314
[Experimental study of evaluation on neuroprotective effect for tetramethylpyrazine against focal cerebral ischemic injury with diffusion-weighted magnetic resonance imaging].	Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20050201
[Evaluation of the efficacy of ligustrazine collaborated with magnesium sulfate in the treatment of pregnancy-induced hypertension in rats].	Shi yan sheng wu xue bao 20050201
[Effects of three Chinese traditional drugs on afferent discharge from single muscle spindle in toads].	Hang tian yi xue yu yi xue gong cheng = Space medicine & medical engineering 20050201
Antioxidative effects of tetramethylpyrazine on acute ethanol-induced lipid peroxidation.	The American journal of Chinese medicine 20050101
Enhancing effects of ligustrazine on expression of CD31 and hematopoietic reconstitution in syngenic bone marrow transplantation of mice.	Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20050101
Effects of ligustrazine on the contraction of isolated rabbit corpus cavernosum strips.	Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20050101
Liquid chromatography-mass spectrometry method for determination of tetramethylpyrazine and its metabolite in dog plasma.	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041225
[Effect of ligustrazine on airway remodeling in asthmatic rats].	Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20041201
Tetramethylpyrazine reduces ischemic brain injury in rats.	Neuroscience letters 20041130
[Effects of combination therapy of rehin and tetramethylpyrazine on experimental hepatic fibrosis induced by tetrachloride].	Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20041101
The electrochemistry and determination of Ligustrazine hydrochloride.	Analytical and bioanalytical chemistry 20041001
[Effect of tetramethylpyrazine on lipopolysaccharides induced macrophage cyclo-oxidase-2 expression and apoptosis of cardiac myocytes].	Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20041001
[Protective effect of tetramethylpyrazine and L-arginine on rats with acute myocardial infarction].	Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20041001
[Study on ligustrazine in reversing multidrug resistance of HepG2/ADM cell in vitro].	Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20041001
Improvement of barrier function and stimulation of colonic epithelial anion secretion by Menoease Pills.	World journal of gastroenterology 20040901
The protective effects of ligustrazine on ischemia-reperfusion and DPPH free radical-induced myocardial injury in isolated rat hearts.	Planta medica 20040901
Protective effect of tetramethylpyrazine on learning and memory function in D-galactose-lesioned mice.	Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih 20040901
Effect of ligustrazine on ischemia-reperfusion injury in murine kidney.	Transplantation proceedings 20040901
Preparative isolation and purification of chuanxiongzine from the medicinal plant Ligusticum chuanxiong by high-speed counter-current chromatography.	Journal of chromatography. A 20040827
[Effect of chuanxiongzine on the relaxation of isolated rabbit corpus cavernosum tissues].	Zhonghua nan ke xue = National journal of andrology 20040801
[Effects of ligustrazine on expression of PECAM-1/CD31 and hematopoietic reconstitution in syngenic bone marrow transplantation of mice].	Zhongguo shi yan xue ye xue za zhi 20040801
[Experimental study on prevention and treatment of bronchial asthma by compound Chinese herbal monomer recipe].	Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20040801
[Study on the interactions between four components in Ligusticum chuanxiong rhizome and acceptors on cardiac muscle membrane].	Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20040701
Differential Cl- and HCO3- mediated anion secretion by different colonic cell types in response to tetromethylpyrazine.	World journal of gastroenterology 20040615
[The effect of ligustrazine on the expression of CD44 in bone marrow of bone marrow transplantation mice].	Zhongguo shi yan xue ye xue za zhi 20040601
[Cardiac hemodynamics after suprarenal ligation of the inferior vena cava and the resection of the right kidney or injection of ligustrazine in rats].	Ai zheng = Aizheng = Chinese journal of cancer 20040501
[Effect of ligustrazine on expressions of basic fibroblast growth factor and its receptor in bone marrow of mice with acute radiation injury].	Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20040501
[Effect of ligustrazine on injury of vascular endothelial cells ECV-304 induced by hypoxia and lack of glucose].	Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20040501
[Effect of ligustrazine on the expression of LFA-1 and ICAM-1 in bone marrow transplantation recipient mice].	Zhongguo shi yan xue ye xue za zhi 20040401
Effects of electroacupuncture plus intra-carotid drug injection on rheoencephalogram in patients with cerebral infarction.	Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 20040301
[Effect of Ligustrazine on the expression of vascular endothelial growth factor in bone marrow stromal cells of radiation injured mice].	Zhongguo shi yan xue ye xue za zhi 20040201
[Progress of the study on effective integredients from Chinese herbal medicine in anti-tumor metastasis].	Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20040201
Type two cytokines predominance of human lung cancer and its reverse by traditional Chinese medicine TTMP.	Cellular & molecular immunology 20040201
Studies on the aroma of cupuassu liquor by headspace solid-phase microextraction and gas chromatography.	Journal of chromatography. A 20040130
Effect of tetramethylpyrazine on acute nociception mediated by signaling of P2X receptor activation in rat.	Brain research 20040109
[Chemical profiles of methylpyrazines contained in commercially available natto].	Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20040101
Nitric oxide-mediated vasorelaxation by Rhizoma Ligustici wallichii in isolated rat thoracic aorta.	Phytomedicine : international journal of phytotherapy and phytopharmacology 20040101
Inhibition of shear-induced platelet aggregation in rat by tetramethylpyrazine and salvianolic acid B.	Clinical hemorheology and microcirculation 20040101
Effect of ligustrazine on the expression of LFA-1, ICAM-1 following bone marrow transplantation in mice.	Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20040101
[Effect of tetromethylpyrazine and aminoguanidine on expression of vascular endothelial growth factor in kidney of diabetic rats].	Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20040101
Pickles, pectin, and penicillin.	Annual review of microbiology 20040101
Preparation of cardiovascular disease-related genes microarray and its application in exploring ligustrazine-induced changes in endothelial gene expression.	Polish journal of pharmacology 20040101
Inhibitory effects of ligustrazine, a modulator of thromboxane-prostacycline-nitric oxide balance, on renal injury in rats with passive Heyman nephritis.	Nephron. Physiology 20040101
The oxygen radical generator pyrogallol impairs cardiomyocyte contractile function via a superoxide and p38 MAP kinase-dependent pathway: protection by anisodamine and tetramethylpyrazine.	Cardiovascular toxicology 20040101
Basolateral membrane mechanisms involved in ligustrazine-stimulated anion secretion in rat distal colon.	Sheng li xue bao : [Acta physiologica Sinica] 20031225
[Protective effect of ligustrazine on insulin resistance after local cerebral ischemia of rat].	Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20031201
Effect of tetramethylpyrazine on exocrine pancreatic and bile secretion.	World journal of gastroenterology 20031115
Tetramethylpyrazine elicits disparate responses in cardiac contraction and intracellular Ca(2+) transients in isolated adult rat ventricular myocytes.	Vascular pharmacology 20031101
Effect of tetramethylpyrazine on potassium channels to lower calcium concentration in cultured aortic smooth muscle cells.	Clinical and experimental pharmacology & physiology 20031001
[Effect of tetramethylpyrazine on learning, memory and cholinergic system in D-galactose-lesioned mice].	Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20031001
[Effect of ligustrazine on cell cycle and prostacyclin of injured vascular endothelial cells induced by hypoxia and lack of glucose].	Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20031001
[Ligustrazine and Salvia miltiorrhiza injection solution in complementary therapy of pregnancy-induced hypertension: clinical analysis of 60 cases].	Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20030901
[Effects of tetramethylpyrazine on cytosolic free calcium concentration in penis corpus cavernsum smooth muscle cells in rabbits].	Zhonghua nan ke xue = National journal of andrology 20030801
[Effect of ligustrazine on proliferative glomerulonephritis].	Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20030801
Effect of tetramethylpyrazine on P-selectin and hepatic/renal ischemia and reperfusion injury in rats.	World journal of gastroenterology 20030715
Synthesis of the novel liqustrazine derivatives and Their protective effect on injured vascular endothelial cell damaged by hydrogen peroxide.	Bioorganic & medicinal chemistry letters 20030707
Convolution method to predict drug concentration profiles of 2,3,5,6-tetramethylpyrazine following transdermal application.	International journal of pharmaceutics 20030618
[Comparing effect in the management of erectile dysfunction by using 2 sets of drugs of intracavernosal injection].	Zhonghua nan ke xue = National journal of andrology 20030601
Tetramethylpyrazine as potassium channel opener to lower calcium influx into cultured aortic smooth muscle cells.	Planta medica 20030601
[Effect of ligustrazine on the expression of Bcl-2 protein and apoptosis in rabbit articular chondrocytes in monolayer culture].	Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University 20030601
Mechanisms responsible for the in vitro relaxation of ligustrazine on porcine left anterior descending coronary artery.	European journal of pharmacology 20030516
[Clinical application and pharmacological actions of ligustrazine].	Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20030501
[Progress on TCM drug-therapy of antagonizing arteriosclerosis].	Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20030501
Iron-induced oxidative damage and apoptosis in cerebellar granule cells: attenuation by tetramethylpyrazine and ferulic acid.	European journal of pharmacology 20030425
AgC(CN)3-based coordination polymers.	Inorganic chemistry 20030421
Tetramethylpyrazine scavenges superoxide anion and decreases nitric oxide production in human polymorphonuclear leukocytes.	Life sciences 20030418
[Effect of tetramethylpyrazine on endothelin, von Willebrand factor and thromboxane A2 during cardiopulmonary bypass in patients of congenital heart disease with pulmonary hypertension].	Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20030401
[Study on the effects of tetramethylpyrazine on tumor cells: survey and prospects].	Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20030401
Physicochemical characterization and percutaneous delivery of 2,3,5,6-tetramethylpyrazine.	International journal of pharmaceutics 20030306
Comparative studies of LFA-1/ICAM-1 interaction by micropipette and flow chamber techniques.	Biorheology 20030101
The effects of Ligustrazine on the expression of bFGF and bFGFR in bone marrow in radiation injured mice.	Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20030101
The prediction of plasma and brain levels of 2,3,5,6-tetramethylpyrazine following transdermal application.	AAPS pharmSci 20021201
In vitro permeation of tetramethylpyrazine across porcine buccal mucosa.	Acta pharmacologica Sinica 20020901
[Preparation and in vitro release of tetramethylpyrazine phosphate pulsincap capsule controlled by an erodible plug].	Yao xue xue bao = Acta pharmaceutica Sinica 20020901
Inhibitory effects of potassium channel blockers on tetramethylpyrazine-induced relaxation of rat aortic strip in vitro.	Life sciences 20020802
[Effect of tetramethylpyrazine on voltage-dependent channels in aortic smooth muscle of rat].	Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20020801
Effects of various principles from Chinese herbal medicine on rhodamine123 accumulation in brain capillary endothelial cells.	Acta pharmacologica Sinica 20020701
Hepatoprotective and therapeutic effects of tetramethylpyrazine on acute econazole-induced liver injury.	Planta medica 20020601
[Effect of ligustrazine on bone marrow hematopoiesis in mice after bone marrow transplantation].	Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20020501
[Effects of ligustrazin on lipid peroxidation during hepatic ischemia reperfusion injury].	Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20020501
Use of gas chromatography-olfactometry to identify key odorant compounds in dark chocolate. Comparison of samples before and after conching.	Journal of agricultural and food chemistry 20020410
[Cultivation of fibroblasts derived from urethral scar and the effects of salviae miltiorrhizae and ligustrazine on its growth].	Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao 20020401
Protective effects of tetramethylpyrazine on kainate-induced excitotoxicity in hippocampal culture.	Neuroreport 20020325
Studies on single-cell adhesion probability between lymphocytes and endothelial cells with micropipette technique.	Microvascular research 20020301
[Protective effect of tetramethylpyrazine on red blood cells during autotransfusion].	Zhonghua yi xue za zhi 20020301
[The intervention effects of Angelica sinensis, Salvia miltiorrhiza and ligustrazine on peritoneal macrophages during peritoneal dialysis].	Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20020301
[Effects of ligustrazine on blood vessels and blood components].	Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20020201
Tetramethylpyrazine attenuates spinal cord ischemic injury due to aortic cross-clamping in rabbits.	BMC neurology 20020101
[Expression of transcription factor T-bet/GATA3 in lung cancer patients and its interference by the traditional Chinese herbal medicine].	Zhonghua zhong liu za zhi [Chinese journal of oncology] 20020101
Protective effect of tetramethylpyrazine on absolute ethanol-induced renal toxicity in mice.	Journal of biomedical science 20020101
Protection by tetramethylpyrazine in acute absolute ethanol-induced gastric lesions.	Journal of biomedical science 20020101
Tetramethylpyrazine protects mice against thioacetamide-induced acute hepatotoxicity.	Journal of biomedical science 20020101
Protective effects of ligustrazine on ischemia-reperfusion injury in rat kidneys.	Microsurgery 20020101
Effect of tetramethylpyrazine on lipid peroxidation in streptozotocin-induced diabetic mice.	The American journal of Chinese medicine 20020101
Effects of ligustrazine on hematopoiesis in the early phase of bone marrow transplantation mice.	Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20020101
The effect of ligustrazine on peritoneal transport in peritoneal dialysis.	Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20020101
[Advances in the study on transdermal permeation of active elements of natural drugs in vitro].	Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20020101
Current studies on anti-endotoxic chemical components of traditional Chinese medicine in China.	Acta pharmacologica Sinica 20011201
[Effect of ligustrazine peritoneal dialysate on CD40 expression of rat peritoneal mesothellial cells].	Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20011201
Specific inhibiting characteristics of tetramethylpyrazine, one of the active ingredients of the Chinese herbal medicine 'Chuanxiong,' on platelet thrombus formation under high shear rates.	Thrombosis research 20011001
Separation and determination of ephedrine alkaloids and tetramethylpyrazine in Ephedra sinica Stapf by gas chromatography-mass spectrometry.	Journal of chromatographic science 20010901
Aqueous flare elevation induced by transcorneal application of highly selective agonists for prostaglandin E2 receptor subtypes in pigmented rabbits: effect of tetramethylpyrazine.	Prostaglandins & other lipid mediators 20010701
Effect of tetramethyl pyrazine on L-type calcium channel in rat ventricular myocytes.	Canadian journal of physiology and pharmacology 20010701
Antithrombotic effects of tetramethylpyrazine in in vivo experiments.	International journal of hematology 20010401
[Transporting into the kidney of medications injected into the renal adipose capsules of rats].	Zhonghua yi xue za zhi 20010325
Pharmacokinetics of tetramethylpyrazine in rat blood and brain using microdialysis.	International journal of pharmaceutics 20010323
[Separation and determination of ephedrine alkaloids and 2,3,5,6-tetramethyl pyrazine in Ephedra herba by HPLC].	Se pu = Chinese journal of chromatography 20010301
[Effect of combination of ligustrazine and nitrendipine on hemodynamics in patients with chronic obstructive pulmonary disease].	Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20010301
Effects of tetramethylpyrazine on prostaglandin E(2)- and prostaglandin E(2) receptor agonist-induced disruption of blood-aqueous barrier in pigmented rabbits.	Japanese journal of ophthalmology 20010101
Ligustrazini inhibits endotoxin induced PAI-1 expression in human umbilical vein endothelial cells.	Journal of Tongji Medical University = Tong ji yi ke da xue xue bao 20010101
Effect of ligustrazine on hematopoiesis in bone marrow transplantation mice.	Journal of Tongji Medical University = Tong ji yi ke da xue xue bao 20010101
[Therapeutic mechanism of combination therapy of ligustrazine and nitrendipine in treating patients with chronic obstructive pulmonary disease].	Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20010101
Effects of tetramethylpyrazine on heart rate and pupil diameter in rats.	Zhongguo yao li xue bao = Acta pharmacologica Sinica 19900901

Effect of dihydropyrazines on human hepatoma HepG2 cells: a comparative study using 2,3-dihydro-5,6-dimethylpyrazine and 3-hydro-2,2,5,6-tetramethylpyrazine.

The Journal of toxicological sciences 20140801

Ligustrazine attenuates elevated levels of indoxyl sulfate, kidney injury molecule-1 and clusterin in rats exposed to cadmium.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20140101

Identification and characterization of a tetramethylpyrazine catabolic pathway in Rhodococcus jostii TMP1.

Applied and environmental microbiology 20130601

Ligustrazine attenuates oxidative stress-induced activation of hepatic stellate cells by interrupting platelet-derived growth factor-β receptor-mediated ERK and p38 pathways.

Toxicology and applied pharmacology 20121115

Development of ligustrazine-loaded lipid emulsion: formulation optimization, characterization and biodistribution.

International journal of pharmaceutics 20121101

Effect of Xiongbing compound on the pharmacokinetics and brain targeting of tetramethylpyrazine.

The Journal of pharmacy and pharmacology 20121101

A modified LC-MS/MS method for determination of tetramethylpyrazine in microdialysis samples and calibration of home-made linear probes.

Biomedical chromatography : BMC 20121001

[Effect of tetramethylpyrazine on the expression of macrophage migration inhibitory factor in acute spinal cord injury in rats].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20121001

Tetramethylpyrazine-mediated suppression of C6 gliomas involves inhibition of chemokine receptor CXCR4 expression.

Oncology reports 20120901

Characterization of cocoa liquors by GC-MS and LC-MS/MS: focus on alkylpyrazines and flavanols.

Journal of mass spectrometry : JMS 20120901

Effects of Ligustrazine on pulmonary damage in rats following scald injury.

Burns : journal of the International Society for Burn Injuries 20120801

Therapeutic effects of tetramethylpyrazine nitrone in rat ischemic stroke models.

Journal of neuroscience research 20120801

Effects of tetramethylpyrazine on cardiac function and mortality rate in septic rats.

Chinese journal of integrative medicine 20120801

Interaction of tetramethylpyrazine with two serum albumins by a hybrid spectroscopic method.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20120701

[Protective effect of Ligustrazine preconditioning on hepatic energy metabolism in ischemia/reperfusion injury of rat].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20120701

Novel multi-functional nitrones for treatment of ischemic stroke.

Bioorganic & medicinal chemistry 20120615

Tetramethylpyrazine reverses multidrug resistance in breast cancer cells through regulating the expression and function of P-glycoprotein.

Medical oncology (Northwood, London, England) 20120601

Microemulsion-based patch for transdermal delivery of huperzine A and ligustrazine phosphate in treatment of Alzheimer's disease.

Drug development and industrial pharmacy 20120601

Inhibition of cyclooxygenase-2 by tetramethylpyrazine and its effects on A549 cell invasion and metastasis.

International journal of oncology 20120601

Ligustrazine phosphate ethosomes for treatment of Alzheimer's disease, in vitro and in animal model studies.

AAPS PharmSciTech 20120601

Integrated investigation of lipidome and related signaling pathways uncovers molecular mechanisms of tetramethylpyrazine and butylidenephthalide protecting endothelial cells under oxidative stress.

Molecular bioSystems 20120601

[Effect of salvia miltiorrhiza and Ligustrazine injection on the early myocardial damage of patients with severe burn].

Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 20120601

Evaluation of antioxidant and immunity function of tetramethylpyrazine phosphate tablets in vivo.

Molecules (Basel, Switzerland) 20120508

Effects of ligustrazine on ureteral obstruction-induced renal tubulointerstitial fibrosis.

Phytotherapy research : PTR 20120501

Selective mGluR1 antagonist EMQMCM inhibits the kainate-induced excitotoxicity in primary neuronal cultures and in the rat hippocampus.

Neurotoxicity research 20120501

Ginsenoside-Rb1 and tetramethylpyrazine phosphate act synergistically to prevent dilated cardiomyopathy in cTnTR141W transgenic mice.

Journal of cardiovascular pharmacology 20120501

Ligustrazine derivatives. Part 4: design, synthesis, and biological evaluation of novel ligustrazine-based stilbene derivatives as potential cardiovascular agents.

Chemical biology & drug design 20120501

[Effects of ligustrazine on the mitochondrial structure and functions in the process myocardial hypertrophy].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20120501

[Garlicin ameliorated pressure overload induced myocardial fibrosis in rats through partial inhibiting TGF-beta1 mediated Smads signal].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20120501

[Effect of different compatibility of tetramethylpyrazine on its pharmacokinetics in vivo].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120501

Synthesis and biological evaluation of new ligustrazine derivatives as anti-tumor agents.

Molecules (Basel, Switzerland) 20120430

TMP prevents retinal neovascularization and imparts neuroprotection in an oxygen-induced retinopathy model.

Investigative ophthalmology & visual science 20120401

[The preparation and evaluation of tissue inducible nerve guide conduit].

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20120401

Synergistic protective effect of astragaloside IV-tetramethylpyrazine against cerebral ischemic-reperfusion injury induced by transient focal ischemia.

Journal of ethnopharmacology 20120306

Preparation and pharmacokinetics in beagle dogs of once-a-day tetramethylpyrazine phosphate sustained-release pellets.

Drug development and industrial pharmacy 20120301

Tetramethylpyrazine attenuates PPAR-γ antagonist-deteriorated oxazolone-induced colitis in mice.

Molecular medicine reports 20120301

Tetramethylpyrazine potentiates arsenic trioxide activity against HL-60 cell lines.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20120301

Transcriptome profiling of heat-resistant strain Bacillus licheniformis CGMCC3962 producing Maotai flavor.

Journal of agricultural and food chemistry 20120227

Effects of Ligustrazine on pancreatic and renal damage after scald injury.

Burns : journal of the International Society for Burn Injuries 20120201

In pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization.

Purinergic signalling 20120201

Ligustrazine attenuates acute lung injury induced by blunt chest trauma.

Saudi medical journal 20120201

Protective effects of ligustrazine on TNF-α-induced endothelial dysfunction.

European journal of pharmacology 20120115

Ligustrazine injection for chronic pulmonary heart disease: a systematic review and meta-analysis.

Evidence-based complementary and alternative medicine : eCAM 20120101

Protective effect of ligustrazine against myocardial ischaemia reperfusion in rats: the role of endothelial nitric oxide synthase.

Clinical and experimental pharmacology & physiology 20120101

Six alkaloids inhibit secretion of IL-1α, TXB(2), ET-1 and E-selectin in LPS-induced endothelial cells.

Immunological investigations 20120101

Meta-analysis of the clinical effect of ligustrazine on diabetic nephropathy.

The American journal of Chinese medicine 20120101

Peripheral arterial and venous response to tilt test after a 60-day bedrest with and without countermeasures (ES-IBREP).

PloS one 20120101

Chinese herb and formulas for promoting blood circulation and removing blood stasis and antiplatelet therapies.

Evidence-based complementary and alternative medicine : eCAM 20120101

Systematic Review of Chinese Herbal Medicines for Preventing in-Stent Coronary Restenosis after Percutaneous Coronary Intervention.

Evidence-based complementary and alternative medicine : eCAM 20120101

The 'brain-skin connection' in protein misfolding and amyloid deposits: embryological, pathophysiological, and therapeutic common grounds?

Frontiers in neurology 20120101

Current situation and perspectives of clinical study in integrative medicine in china.

Evidence-based complementary and alternative medicine : eCAM 20120101

Ligustrazine attenuates myocardial ischemia reperfusion injury in rats by activating the phosphatidylinositol 3-kinase/Akt pathway.

Annals of clinical and laboratory science 20120101

Outcome measures of chinese herbal medicine for coronary heart disease: an overview of systematic reviews.

Evidence-based complementary and alternative medicine : eCAM 20120101

TREM-1 Promotes Pancreatitis-Associated Intestinal Barrier Dysfunction.

Gastroenterology research and practice 20120101

Understanding the mechanism of hepatic fibrosis and potential therapeutic approaches.

Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association 20120101

Preparation of natural borneol/2-hydroxypropyl-β-cyclodextrin inclusion complex and its effect on the absorption of tetramethylpyrazine phosphate in mouse.

Chemical & pharmaceutical bulletin 20120101

Traditional Japanese herbal (kampo) medicines and treatment of ocular diseases: a review.

The American journal of Chinese medicine 20120101

Protective effects of Ligustrazine, Kakonein and Panax Notoginsenoside on the small intestine and immune organs of rats with severe acute pancreatitis.

Hepatobiliary & pancreatic diseases international : HBPD INT 20111201

Ligustrazine derivatives. Part 5: design, synthesis and biological evaluation of novel ligustrazinyloxy-cinnamic acid derivatives as potent cardiovascular agents.

European journal of medicinal chemistry 20111101

[Molecular mechanism of tetramethylpyrazine to induce human promyelocytic HL-60 leukemia cells differentiation].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20111101

Protective effect of tetramethylpyrazine isolated from Ligusticum chuanxiong on nephropathy in rats with streptozotocin-induced diabetes.

Phytomedicine : international journal of phytotherapy and phytopharmacology 20111015

Tetramethylpyrazine inhibits migration of SKOV3 human ovarian carcinoma cells and decreases the expression of interleukin-8 via the ERK1/2, p38 and AP-1 signaling pathways.

Oncology reports 20110901

Ligustrazine inhibits lipopolysaccharide-induced proliferation by affecting P27, Bcl-2 expression in rat mesangial cells.

European journal of pharmacology 20110831

Ligustrazine improves atherosclerosis in rat via attenuation of oxidative stress.

Pharmaceutical biology 20110801

[Inhalation of aerosolized perfluorocarbon combined with tetramethylpyrazine ameliorates hemodynamics and pulmonary histopathology in a porcine model of acute lung injury].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20110801

Ligustrazine formation in Zhenjiang aromatic vinegar: changes during fermentation and storing process.

Journal of the science of food and agriculture 20110701

Tetramethylpyrazine protects spinal cord and reduces inflammation in a rat model of spinal cord ischemia-reperfusion injury.

Journal of vascular surgery 20110701

Protective effects and mechanism of tetramethylpyrazine against lens opacification induced by sodium selenite in rats.

Experimental eye research 20110701

Chuanxiongzine-astragaloside IV decreases IL-1β and Caspase-3 gene expressions in rat brain damaged by cerebral ischemia/reperfusion: a study of real-time quantitative PCR assay.

Sheng li xue bao : [Acta physiologica Sinica] 20110625

Volatile analysis of ground almonds contaminated with naturally occurring fungi.

Journal of agricultural and food chemistry 20110608

Effect of ligustrazine on mice model of hepatic veno-occlusive disease induced by Gynura segetum.

Journal of gastroenterology and hepatology 20110601

Pharmacokinetic study of a novel stroke therapeutic, 2-[[(1,1-dimethylethyl)oxidoimino]methyl]-3,5,6-trimethylpyrazine, by a simple HPLC-UV method in rats.

European journal of drug metabolism and pharmacokinetics 20110601

A comprehensive evaluation of the toxicology of cigarette ingredients: heterocyclic nitrogen compounds.

Inhalation toxicology 20110601

(E,E,E,E)-2,3,5,6-Tetra-kis{2-[4-(dimethyl-amino)-phen-yl]ethen-yl}pyrazine.

Acta crystallographica. Section E, Structure reports online 20110601

Transcriptome analysis of the effects of gomisin a on the recovery of carbon tetrachloride-induced damage in rat liver.

Laboratory animal research 20110601

[Effect of tetramethylpyrazine on JAK-STAT signal transduction in cardiomyocyte hypertrophy].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20110501

Tetramethylpyrazine protects palmitate-induced oxidative damage and mitochondrial dysfunction in C2C12 myotubes.

Life sciences 20110425

The protective mechanism of ligustrazine against renal ischemia/reperfusion injury.

The Journal of surgical research 20110401

Comparison of fermented soybean paste (Doenjang) prepared by different methods based on profiling of volatile compounds.

Journal of food science 20110401

Monoclinic polymorph of 2,5-bis[4-(dimethyl-amino)-styr-yl]-3,6-dimethyl-pyrazine.

Acta crystallographica. Section E, Structure reports online 20110401

Additive effect of tetramethylpyrazine and deferoxamine in the treatment of spinal cord injury caused by aortic cross-clamping in rats.

Spinal cord 20110201

3-(4-Hy-droxy-3-meth-oxy-phen-yl)acrylic acid-2,3,5,6-tetra-methyl-pyrazine (2/1).

Acta crystallographica. Section E, Structure reports online 20110201

An antioxidant phytotherapy to rescue neuronal oxidative stress.

Evidence-based complementary and alternative medicine : eCAM 20110101

Mediation of Endogenous β-Endorphin in the Plasma Glucose-Lowering Action of Herbal Products Observed in Type 1-Like Diabetic Rats.

Evidence-based complementary and alternative medicine : eCAM 20110101

Antihypertension Induced by Tanshinone IIA Isolated from the Roots of Salvia miltiorrhiza.

Evidence-based complementary and alternative medicine : eCAM 20110101

Kainic acid-induced neurodegenerative model: potentials and limitations.

Journal of biomedicine & biotechnology 20110101

Pathophysiology, treatment, and animal and cellular models of human ischemic stroke.

Molecular neurodegeneration 20110101

[Protective effect of valsartan or/and ligustrazine on hippocampal neuronal loss in rats with vascular dementia].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20110101

Differential proteomic analysis of platelets suggested possible signal cascades network in platelets treated with salvianolic acid B.

PloS one 20110101

Tetramethylpyrazine inhibits hypoxia-induced pulmonary vascular leakage in rats via the ROS-HIF-VEGF pathway.

Pharmacology 20110101

Preparation of a ligustrazine ethosome patch and its evaluation in vitro and in vivo.

International journal of nanomedicine 20110101

Attenuating effect of pretreatment with Yiqifumai on lipopolysaccharide-induced intestine injury and survival rate in rat.

Journal of inflammation (London, England) 20110101

Effect of Guanabenz on Rat AMD Models and Rabbit Choroidal Blood Flow.

The open ophthalmology journal 20110101

Effect of Ligusticum wallichii aqueous extract on oxidative injury and immunity activity in myocardial ischemic reperfusion rats.

International journal of molecular sciences 20110101

Anti-inflammatory effects of Chinese medicinal herbs on cerebral ischemia.

Chinese medicine 20110101

Pharmacokinetics of ligustrazine ethosome patch in rats and anti-myocardial ischemia and anti-ischemic reperfusion injury effect.

International journal of nanomedicine 20110101

Mechanisms underlying purinergic P2X3 receptor-mediated mechanical allodynia induced in diabetic rats.

Molecular pain 20110101

Role of Bone Morphogenetic Proteins-7 (BMP-7) in the Renal Improvement Effect of DangGui (Angelica sinensis) in Type-1 Diabetic Rats.

Evidence-based complementary and alternative medicine : eCAM 20110101

Microemulsion-based novel transdermal delivery system of tetramethylpyrazine: preparation and evaluation in vitro and in vivo.

International journal of nanomedicine 20110101

Preparation and evaluation of quercetin-loaded lecithin-chitosan nanoparticles for topical delivery.

International journal of nanomedicine 20110101

Evaluation of the Possible Mechanisms of Antihypertensive Activity of Loranthus micranthus: An African Mistletoe.

Biochemistry research international 20110101

The importance of the stem cell marker prominin-1/CD133 in the uptake of transferrin and in iron metabolism in human colon cancer Caco-2 cells.

PloS one 20110101

Enhanced transdermal delivery of evodiamine and rutaecarpine using microemulsion.

International journal of nanomedicine 20110101

A review on mucoadhesive polymer used in nasal drug delivery system.

Journal of advanced pharmaceutical technology & research 20110101

Cytoprotective effects of CSTMP, a novel stilbene derivative, against H2O2-induced oxidative stress in human endothelial cells.

Pharmacological reports : PR 20110101

P2X receptors and modulation of pain transmission: focus on effects of drugs and compounds used in traditional Chinese medicine.

Neurochemistry international 20101201

Effects of tetramethylpyrazine on nitric oxide/cGMP signaling after cerebral vasospasm in rabbits.

Brain research 20101118

The protective effect of tetramethylpyrazine on cartilage explants and chondrocytes.

Journal of ethnopharmacology 20101111

Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples.

Archives of toxicology 20101101

Synthesis of novel ligustrazine derivatives as NA+/H+ exchange inhibitors.

Chemistry & biodiversity 20101101

Ligustrazine as a salvage agent for patients with relapsed or refractory non-Hodgkin's lymphoma.

Chinese medical journal 20101101

Protective effects of ligustrazine, kakonein and Panax notoginsenosides on multiple organs in rats with severe acute pancreatitis.

Methods and findings in experimental and clinical pharmacology 20101101

Impacts of bicyclo-monoterpene enhancers on transdermal delivery of ligustrazine.

Yao xue xue bao = Acta pharmaceutica Sinica 20101101

A feeding strategy for tetramethylpyrazine production by Bacillus subtilis based on the stimulating effect of ammonium phosphate.

Bioprocess and biosystems engineering 20101001

Coadministration of huperzine A and ligustrazine phosphate effectively reverses scopolamine-induced amnesia in rats.

Pharmacology, biochemistry, and behavior 20101001

TMPDP, a tetramethylpyrazine derivative, protects vascular endothelial cells from oxidation damage by hydrogen peroxide.

Die Pharmazie 20101001

[Simultaneous determination of five effective components in Rhizoma Chuanxiong by RP-HPLC].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101001

[Permeability of blood-brain barrier oxygen-glucose deprivation induced by tetramethylpyrazine-puerarin in vitro].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101001

[Pharmacokinetics studies on tetramethylpyrazine by intravenous administration in rats].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20101001

[Inhibitory effect of TBN on platelet aggregation in rabbit].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100901

Volatile composition and sensory analysis of Italian gianduja torrone.

Journal of the science of food and agriculture 20100815

Production of tetramethylpyrazine by batch culture of Bacillus subtilis with optimal pH control strategy.

Journal of industrial microbiology & biotechnology 20100801

[Effect of ligustrazine hydrocklorde on induced alcoholic fatty liver in vitro].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20100801

[Determination of plasma protein binding rate of tetramethylpyrazine phosphate by ultrafiltration].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100801

Alleviation of CCl4-induced cirrhosis in rats by tetramethylpyrazine is associated with downregulation of leptin and TGF-beta1 pathway.

Drug and chemical toxicology 20100701

[Perioperative intervention of tetramethylpyrazine on free skin flap transplantation].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20100701

Tetramethylpyrazine inhibits production of nitric oxide and inducible nitric oxide synthase in lipopolysaccharide-induced N9 microglial cells through blockade of MAPK and PI3K/Akt signaling pathways, and suppression of intracellular reactive oxygen species.

Journal of ethnopharmacology 20100616

Neuroprotection and enhanced neurogenesis by tetramethylpyrazine in adult rat brain after focal ischemia.

Neurological research 20100601

Tetramethylpyrazine promotes proliferation and differentiation of neural stem cells from rat brain in hypoxic condition via mitogen-activated protein kinases pathway in vitro.

Neuroscience letters 20100419

[Comparative study on pharmacokinetics of tetramethylpyrazine, ferulic acid and their compatibility].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100401

[Effects of tetramethylpyrazine on fractalkine and tumor necrosis factor-alpha expression in patients with chronic pulmonary heart disease].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20100401

Chuanxiongzine relaxes isolated corpus cavernosum strips and raises intracavernous pressure in rabbits.

International journal of impotence research 20100301

Protective action of tetramethylpyrazine phosphate against dilated cardiomyopathy in cTnT(R141W) transgenic mice.

Acta pharmacologica Sinica 20100301

Stabilization of mitochondrial function by tetramethylpyrazine protects against kainate-induced oxidative lesions in the rat hippocampus.

Free radical biology & medicine 20100215

Effect of tetramethylpyrazine on DRG neuron P2X3 receptor involved in transmitting pain after burn.

Burns : journal of the International Society for Burn Injuries 20100201

High-yield fermentative preparation of tetramethylpyrazine by Bacillus sp. using an endogenous precursor approach.

Journal of industrial microbiology & biotechnology 20100201

[Effect of Ligusticum and its two main components on muscle atrophy in a hind limb unloaded rat model].

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20100201

The effect of tetramethylpyrazine on hydrogen peroxide-induced oxidative damage in human umbilical vein endothelial cells.

Basic & clinical pharmacology & toxicology 20100101

Inhibition of tetramethylpyrazine on P-gp, MRP2, MRP3 and MRP5 in multidrug resistant human hepatocellular carcinoma cells.

Oncology reports 20100101

Mechanism of tetramethylpyrazine analogue CXC195 inhibition of hydrogen peroxide-induced apoptosis in human endothelial cells.

Biological & pharmaceutical bulletin 20100101

Alkylpyrazines and other volatiles in cocoa liquors at pH 5 to 8, by Selected Ion Flow Tube-Mass Spectrometry (SIFT-MS).

Journal of food science 20100101

Stem cell-based neuroprotective and neurorestorative strategies.

International journal of molecular sciences 20100101

Circumvention of multi-drug resistance of cancer cells by Chinese herbal medicines.

Chinese medicine 20100101

Endothelium-independent vasorelaxation by Ligusticum wallichii in isolated rat aorta: comparison of a butanolic fraction and tetramethylpyrazine, the main active component of Ligusticum wallichii.

Biological & pharmaceutical bulletin 20100101

Effect of salvianolic acid B and paeonol on blood lipid metabolism and hemorrheology in myocardial ischemia rabbits induced by pituitruin.

International journal of molecular sciences 20100101

Herb network construction and co-module analysis for uncovering the combination rule of traditional Chinese herbal formulae.

BMC bioinformatics 20100101

Effect of Tetramethylpyrazine on RPE degeneration, choroidal blood flow and oxidative stress of RPE cells.

International journal of ophthalmology 20100101

Traditional Chinese medicine Bak Foong Pills alters uterine quiescence - possible role in alleviation of dysmenorrhoeal symptoms.

Cell biology international 20091201

[Relationship of tetramethylpyrazine on expression of vascular endothelial growth factor and development of adjuvant-induced arthritis in rats].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20091101

[Studies on protection and mechanism of tetramethylpyrazine on myocardial injury of rats with DHF].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20091101

Syntheses, structures, and photoluminescence of a series of silver(I) sulfonates with pyrazine derivatives.

Dalton transactions (Cambridge, England : 2003) 20091014

[Artificial neural network parameters optimization software and its application in the design of sustained release tablets].

Yao xue xue bao = Acta pharmaceutica Sinica 20091001

Formation and identification of trimethylimidazole during tetramethylpyrazine production from glucose by Bacillus strains.

Biotechnology letters 20090901

Ligustrazine inhibits B16F10 melanoma metastasis and suppresses angiogenesis induced by Vascular Endothelial Growth Factor.

Biochemical and biophysical research communications 20090821

Tetramethylpyrazine suppresses interleukin-8 expression in LPS-stimulated human umbilical vein endothelial cell by blocking ERK, p38 and nulear factor-kappaB signaling pathways.

Journal of ethnopharmacology 20090817

[Protective effects of tetramethylpyrazine on rat myocardial cells infected by Coxsackie virus B3 and its signal transduction mechanism].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20090801

[Effects of tetramethylpyrazine on thrombin-induced tissue factor expression in vascular endothelial cells].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20090801

[The enhancing effect of borneol on the absorption of tetramethylpyrazine].

Yao xue xue bao = Acta pharmaceutica Sinica 20090801

Development of a GC x GC-TOFMS method using SPME to determine volatile compounds in cacao beans.

Journal of separation science 20090701

[Effect of tetramethylpyrazine added to vitrification solution on peripheral nerve allografts regeneration].

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery 20090701

Brain pharmacokinetics of tetramethylpyrazine after intranasal and intravenous administration in awake rats.

International journal of pharmaceutics 20090622

Comparative protective effect of N-acetyl cysteine and tetramethylpyrazine in rats with gentamicin nephrotoxicity.

Journal of applied toxicology : JAT 20090501

Ligustrazine derivatives. Part 3: Design, synthesis and evaluation of novel acylpiperazinyl derivatives as potential cerebrocardiac vascular agents.

Bioorganic & medicinal chemistry 20090415

In reference to Fu et al. (neuro-Oncology 2008:10139-152).

Neuro-oncology 20090401

Antioxidative effect of the herbal remedy Qin Huo Yi Hao and its active component tetramethylpyrazine on high glucose-treated endothelial cells.

Life sciences 20090327

Antioxidation and anti-inflammation by haem oxygenase-1 contribute to protection by tetramethylpyrazine against gentamicin-induced apoptosis in murine renal tubular cells.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20090301

Protective effect of tetraethyl pyrazine against focal cerebral ischemia/reperfusion injury in rats: therapeutic time window and its mechanism.

Thrombosis research 20090301

[Effects of tetramethylpyrazine on angiotensin II -induced proliferation and type I collagen synthesis of rat cardiac fibroblasts].

Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20090301

Hydrogen sulfide protects from intestinal ischaemia-reperfusion injury in rats.

The Journal of pharmacy and pharmacology 20090201

Therapeutic time window and mechanism of tetramethylpyrazine on transient focal cerebral ischemia/reperfusion injury in rats.

Neuroscience letters 20090102

[Effects of ligustrazine injection on high glucose-induced type I collagen, matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 expressions in human peritoneal mesothelial cells in vitro].

Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20090101

Atorvastatin ameliorates cerebral vasospasm and early brain injury after subarachnoid hemorrhage and inhibits caspase-dependent apoptosis pathway.

BMC neuroscience 20090101

[Effect of tetramethylpyrazine on expression of Smad7 and SnoN in rats with UUO].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090101

Chinese medicines as a resource for liver fibrosis treatment.

Chinese medicine 20090101

Neurological and neurobehavioral assessment of experimental subarachnoid hemorrhage.

BMC neuroscience 20090101

Purinergic mechanosensory transduction and visceral pain.

Molecular pain 20090101

Protective effect of chuanxiongzine-puerarin in a rat model of transient middle cerebral artery occlusion-induced focal cerebral ischemia.

Nuclear medicine communications 20081201

[The influence of JNK inhibitor on hemodynamics after ischemia/reperfusion injury to the heart in rats].

Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20081201

Forty-six cases of vertebrobasilar insufficiency treated by acupuncture plus intravenous infusion of ligustrazine.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 20081201

Effect of chitosan structure properties and molecular weight on the intranasal absorption of tetramethylpyrazine phosphate in rats.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20081101

[Effect of ligustrazine on expression of RhoA mRNA, ROCK-II protein in the lung and airway inflammation of allergic asthma model mice].

Zhonghua er ke za zhi = Chinese journal of pediatrics 20081101

[Regulatory effect of ligustrazine and Radix astragalus on RANTES and receptor CCR5 expression in the genesis and development process of endometriosis].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20081101

[Effects of ligustrazine on extracellular acetylcholine levels in rat brain dialysate].

Yao xue xue bao = Acta pharmaceutica Sinica 20081101

Ferulic acid, but not tetramethylpyrazine, significantly attenuates retinal ischemia/reperfusion-induced alterations by acting as a hydroxyl radical scavenger.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20081001

Antioxidative and thrombolytic TMP nitrone for treatment of ischemic stroke.

Bioorganic & medicinal chemistry 20081001

Effect of tetramethylpyrazine on primary afferent transmission mediated by P2X3 receptor in neuropathic pain states.

Brain research bulletin 20080905

Effect of ligustrazine injection on levels of interleukin-4 and interferon-gamma in patients with bronchial asthma.

Chinese journal of integrative medicine 20080901

[The efficacy of tetramethylpyrazine-eluting stents on inhibiting neointima formation in porcine coronary arteries].

Zhonghua xin xue guan bing za zhi 20080901

Anti-apoptotic and neuroprotective effects of Tetramethylpyrazine following subarachnoid hemorrhage in rats.

Autonomic neuroscience : basic & clinical 20080818

[Mechanism of ligustrazine promoting hematopoietic reconstitution in syngenic bone marrow transplanted mice].

Zhongguo shi yan xue ye xue za zhi 20080801

[Tetramethylpyrazine accelerated spinal cord repair through regulation of caspase-3 and neurofilament protein expression: an acute spinal cord injury model in rats].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20080801

[Determination and fingerprint analysis of tetramethylpyrazine and ferulic acid in Ligusticum chuanxiong].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080801

Amelioration of cisplatin-induced nephrotoxicity in rats by tetramethylpyrazine, a major constituent of the Chinese herb Ligusticum wallichi.

Experimental biology and medicine (Maywood, N.J.) 20080701

[Effect of acupuncture on target action of ligustrazine in treatment of toxic deafness induced by gentamicin in guinea pigs].

Zhongguo zhen jiu = Chinese acupuncture & moxibustion 20080701

Protective effects of tetramethylpyrazine on rat retinal cell cultures.

Neurochemistry international 20080501

[Effects of tetramethylpyrazine on the scores of the water maze and the long-term potentiation of hippocampus in epileptic Sprague Dawley rats].

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20080501

Preparation of molecularly imprinted adsorptive resin for trapping of ligustrazine from the traditional Chinese herb Ligusticum chuanxiong Hort.

Analytica chimica acta 20080407

Tetramethylpyrazine inhibits activities of glioma cells and glutamate neuro-excitotoxicity: potential therapeutic application for treatment of gliomas.

Neuro-oncology 20080401

[Impacts of tetramethylpyrazine on BDNF, bFGF expression and neuron-protection in severe brain injury tissue of rat].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20080301

[Effects of tetramethylpyrazine on endothelin and nitric oxide contents in plasma and cerebrospinal fluid after subarachnoid hemorrhage].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20080301

Biocompatibility of tetramethylpyrazine-eluting stents in normal porcine coronary arteries.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20080201

[Effect of puerarin and ligustrazine on cultured hippocampal neurons injury induced by Abeta25-35].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080201

[Influence of borneol on nasal absorption of Ligustrazinee].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080201

[Optimization of ligustrazine phosphate thermosensitive gel formulation by central composite design-response surface methodology].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080201

Protective effect of tetramethylpyrazine and salvianolic acid B on apoptosis of rat cerebral microvascular endothelial cell under high shear stress.

Clinical hemorheology and microcirculation 20080101

A simple gas chromatographic method for the simultaneous determination and pharmacokinetic study of tetramethylpyrazine phosphate and borneol in mouse plasma and brain tissue after oral administration of the fufang tetramethylpyrazine phosphate tablets.

Journal of chromatographic science 20080101

Suppression of blood lipid concentrations by volatile Maillard reaction products.

Nutrition (Burbank, Los Angeles County, Calif.) 20080101

Effect of ligustrazine on chronic allograft nephropathy in rats.

Transplantation proceedings 20071201

[Effect of tetramethylpyrazine on platelet activation and vascular endothelial function in patients with acute coronary syndrome undergoing percutaneous coronary intervention].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20071201

[Ligustrazine and cimetidine therapy for the prevention of Henoch-Schonlein purpura nephritis in children: a follow-up study of 380 cases].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20071001

Muscle composition after 14-day hindlimb unloading in rats: effects of two herbal compounds.

Aviation, space, and environmental medicine 20071001

Pharmacological activity of cardiovascular agents from herbal medicine.

Cardiovascular & hematological agents in medicinal chemistry 20071001

[Effects of acupoint-embedding of medicinal thread and electroacupuncture on contents of TNF-alpha and IL-6 of hippocampus tissue in rats with focal cerebral ischemia-reperfusion injury].

Zhen ci yan jiu = Acupuncture research 20071001

Effects of cinnamene enhancers on transdermal delivery of ligustrazine hydrochloride.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20070901

[Aqueous humor penetration of ligustrazine hydrochloride eye drops after topical administration in rabbit eyes].

Yan ke xue bao = Eye science 20070901

Attenuation of streptomycin ototoxicity by tetramethylpyrazine and its effect on K⁺ channels in the outer hair cells of guinea pig cochlea.

Sheng li xue bao : [Acta physiologica Sinica] 20070825

Tetramethylpyrazine-eluting stents prevented in-stent restenosis in a porcine model.

Journal of cardiovascular pharmacology 20070801

Quantitative study of the drug efflux kinetics from sensitive and MDR human breast cancer cells.

Biochimica et biophysica acta 20070701

[Effects of tetramethylpyrazine on brain oxidative damage induced by intracerebral perfusion of L-DOPA in rats with Parkinson's disease].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20070701

Tetramethylpyrazine inhibits agiontensin II-induced nuclear factor-kappaB activation and bone morphogenetic protein-2 downregulation in rat vascular smooth muscle cells.

Sheng li xue bao : [Acta physiologica Sinica] 20070625

Supramolecular synthon polymorphism in 2 : 1 co-crystal of 4-hydroxybenzoic acid and 2,3,5,6-tetramethylpyrazine.

Chemical communications (Cambridge, England) 20070621

The enhancing effect of synthetical borneol on the absorption of tetramethylpyrazine phosphate in mouse.

International journal of pharmaceutics 20070607

Protective effect of ligustrazine on accelerated anti-glomerular basement membrane antibody nephritis in rats is based on its antioxidant properties.

European journal of pharmacology 20070601

Delayed protection of tetramethylpyrazine on neonatal rat cardiomyocytes subjected to anoxia-reoxygenation injury.

Basic & clinical pharmacology & toxicology 20070601

[Effect of ligustrazine on nNOS expression and neuranagenesis in adult rats after cerebral ischemia-reperfusion injury].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20070601

[Relationship between cardiomyocyte protein synthesis and cell viability].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20070601

[Effect of ligustrazine on cell proliferation in subventricular zone in rat brain with focal cerebral ischemia-reperfusion injury].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20070601

Design, synthesis, and biological activities of novel Ligustrazine derivatives.

Bioorganic & medicinal chemistry 20070515

Ligustrazine attenuates acute myocardium injury after thermal trauma.

Burns : journal of the International Society for Burn Injuries 20070501

Neuroprotective effects of tetramethylpyrazine on hydrogen peroxide-induced apoptosis in PC12 cells.

Cell biology international 20070501

[Effect of ligustrazine on migration of neuronal precursors after focal cerebral ischemia in adult rats].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20070501

[Effect of ligustrazine and L-arginine on function of mitochondria in myocardium after ischemia/reperfusion injury of myocardium in rabbits].

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20070501

Ligustrazine alleviates gastric mucosal injury in a rat model of acute necrotizing pancreatitis.

Hepatobiliary & pancreatic diseases international : HBPD INT 20070401

Tetramethylpyrazine protects rat renal tubular cell apoptosis induced by gentamicin.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20070301

Tetramethylpyrazine suppresses HIF-1alpha, TNF-alpha, and activated caspase-3 expression in middle cerebral artery occlusion-induced brain ischemia in rats.

Acta pharmacologica Sinica 20070301

[Establishment of oxygen and glucose deprive model of in vitro cultured hippocampal neuron and effect of ligustrazine on intracellular Ca+ level in model neurons].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20070301

Proteomic analysis of the effects of tetramethylpyrazine on irradiated QXMSC1 cells.

Biological & pharmaceutical bulletin 20070201

[Effect of ligustrazine on expression of Fas/FasL in pulmonary injury induced by ischemia/reperfusion in rabbits].

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20070201

The cardioprotective effect of isosteviol on rats with heart ischemia-reperfusion injury.

Life sciences 20070102

Effect of tetramethylpyrazine on rat experimental choroidal neovascularization in vivo and endothelial cell cultures in vitro.

Current eye research 20070101

Effect and mechanism of ligustrazine on Th1/Th2 cytokines in a rat asthma model.

The American journal of Chinese medicine 20070101

Tetramethylpyrazine inhibits angiotensin II-increased NAD(P)H oxidase activity and subsequent proliferation in rat aortic smooth muscle cells.

The American journal of Chinese medicine 20070101

Ligustrazine alleviates acute renal injury in a rat model of acute necrotizing pancreatitis.

World journal of gastroenterology 20061221

Tetramethylpyrazine production from glucose by a newly isolated Bacillus mutant.

Applied microbiology and biotechnology 20061201

[Study on metabolism of tetramethylpyrazine in system of rat liver microsomes].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061201

X-ray diffraction and inelastic neutron scattering study of 1:1 tetramethylpyrazine chloranilic acid complex: temperature, isotope, and pressure effects.

The Journal of chemical physics 20061121

Ligustrazine alleviates acute lung injury in a rat model of acute necrotizing pancreatitis.

Hepatobiliary & pancreatic diseases international : HBPD INT 20061101

[The effect of ligustrazine on cells proliferation in cortex and striatum after focal cerebral ischemia in adult rats].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20061101

Preventive effect of tetramethylpyrazine on intestinal mucosal injury in rats with acute necrotizing pancreatitis.

World journal of gastroenterology 20061021

[Effects of ligustrazine on hippocampal dentate gyrus cell proliferation after focal cerebral ischemia in adult rats].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20061001

[Effect of ligustrazine on the expression of bFGF in bone marrow stromal cells of mice after BMT].

Zhongguo shi yan xue ye xue za zhi 20061001

[Effects of tetramethylpyrazine on expression of vascular endothelial growth factor and hypoxia-induced factor-1alpha by rat peritoneal macrophages].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061001

Tetramethylpyrazine induces heme oxygenase-1 expression and attenuates myocardial ischemia/reperfusion injury in rats.

Journal of biomedical science 20060901

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology 20060901

[Effect of ligustrazine on cell proliferation in subventricular zone of lateral cerebral ventricle after adult rat suffering from focal cerebral ischemia].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20060901

[The effect of tetramethylpyrazine on the pharmacokinetics of intragastrically administered cyclosporine A in rats].

Yao xue xue bao = Acta pharmaceutica Sinica 20060901

[Effects of ligustrazine injection on lymph circulation in rats with acute microcirculation disturbance].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20060901

Effect of citric acid and glycine addition on acrylamide and flavor in a potato model system.

Journal of agricultural and food chemistry 20060809

Tetramethylpyrazine attenuates adriamycin-induced apoptotic injury in rat renal tubular cells NRK-52E.

Planta medica 20060801

[Therapeutic effects of intraarticular injection of ligustrazine on knee osteoarthritis].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20060801

[Inhibition of extracts from 17 Chinese herbs on periodontal pathogenic microbes].

Shanghai kou qiang yi xue = Shanghai journal of stomatology 20060801

[Investigation of the in vivo desintegration and transit behavior of tetramethylpyrazine phosphate pulsincap capsule in the gastrointestinal tract of dogs by gamma scintigraphy].

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20060801

[Effects of D-limonene and L-limonene on transdermal absorption of ligustrazine hydrochloride].

Yao xue xue bao = Acta pharmaceutica Sinica 20060801

[Effect of ligustrazine, synthetic borneol on lasting time of ciliary movement].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20060801

[The effects of tetramethylpyrazine on lung injury induced by brain ischemia/reperfusion].

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20060801

Effects of four Si-Wu-Tang's constituents and their combination on irradiated mice.

Biological & pharmaceutical bulletin 20060701

[Effect of Ligustrazine on type I, III collagen synthesis in lung tissue of silica-treated rat].

Wei sheng yan jiu = Journal of hygiene research 20060701

Simultaneous determination of Gastrodin and Ligustrazine hydrochloride in dog plasma by gradient high-performance liquid chromatography.

Journal of pharmaceutical and biomedical analysis 20060616

Involvement of intracellular and extracellular Ca2+ in tetramethylpyrazine-induced colonic anion secretion.

Cell biology international 20060601

Effect of Ligustrazine on liver injury after burn trauma.

Burns : journal of the International Society for Burn Injuries 20060501

Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Inhibitory mechanisms of tetramethylpyrazine in middle cerebral artery occlusion (MCAO)-induced focal cerebral ischemia in rats.

Planta medica 20060401

Low frequency internal modes of 1,2,4,5-tetramethylbenzene, tetramethylpyrazine and tetramethyl-1,4-benzoquinone INS, Raman, infrared and theoretical DFT studies.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20060301

[The effects of tetramethylpyrazine in combination with rhein on proliferation and apoptosis in human liver cell L-02 induced by TGFb1 and TG].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20060301

[Protective effect of ligustrazine and propofol on peri-operational liver ischemia-reperfusion injury].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20060301

Ligustrazine inhibits high voltage-gated Ca(2+) and TTX-resistant Na(+) channels of primary sensory neuron and thermal nociception in the rat: a study on peripheral mechanism.

Neuroscience bulletin 20060301

[Effects of tetramethylpyrazine on large-conductance Ca²⁺-activated potassium channels in porcine coronary artery smooth muscle cells].

Sheng li xue bao : [Acta physiologica Sinica] 20060225

Neuroprotection by tetramethylpyrazine against ischemic brain injury in rats.

Neurochemistry international 20060201

[Effects of tetramethylpyrazine on fibrosis of atrial tissue and atrial fibrillation in a canine model of congestive heart failure induced by ventricular tachypacing].

Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20060101

Simple high-performance liquid chromatographic method for the determination of tetramethylpyrazine phosphate in very small volumes of dog plasma: application to a pharmacokinetic study.

Journal of chromatographic science 20060101

[Interferential effect of ligustrazine injection on lymph circulation during the recovery of hemorrhagic shock in rats].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20060101

Anti-apoptotic and neuroprotective effects of Tetramethylpyrazine following spinal cord ischemia in rabbits.

BMC neuroscience 20060101

Effects of enantiomer and isomer permeation enhancers on transdermal delivery of ligustrazine hydrochloride.

Pharmaceutical development and technology 20060101

Preclinical and clinical examinations of Salvia miltiorrhiza and its tanshinones in ischemic conditions.

Chinese medicine 20060101

The underlying cellular mechanism in the effect of tetramethylpyrazine on the anion secretion of colonic mucosa.

The Japanese journal of physiology 20051201

[Effect of ligustrazine on the expression and activity of heme oxygenase-1 in the pulmonary ischemia/reperfusion injury in rabbits].

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20051101

Tetramethylpyrazine downregulates angiotensin II-induced endothelin-1 gene expression in vascular endothelial cells.

Clinical and experimental pharmacology & physiology 20051001

Role of cGMP signals in tetramethylpyrazine induced relaxation of the isolated rat aortic strip.

Life sciences 20050812

[Effects of Ligustrazine and Radix Astragali on activities of myosin adenosine triphosphatase of soleus muscle and muscle atrophy in tail-suspended rats].

Hang tian yi xue yu yi xue gong cheng = Space medicine & medical engineering 20050801

[Protective effects of ligustrazine against photoreceptor cell injury induced by N-methyl-N-nitrosourea and its mechanism].

Yao xue xue bao = Acta pharmaceutica Sinica 20050801

Tetramethylpyrazine stimulates cystic fibrosis transmembrane conductance regulator-mediated anion secretion in distal colon of rodents.

World journal of gastroenterology 20050721

Tetramethylpyrazine protected photoreceptor cells of rats by modulating nuclear translocation of NF-kappaB.

Acta pharmacologica Sinica 20050701

Inhibition of cyclic strain-induced endothelin-1 secretion by tetramethylpyrazine.

Clinical and experimental pharmacology & physiology 20050701

[Protective effect of tetramethylpyrazine on the respiratory inhibition induced by hypoxia in rats].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20050701

Ligustrazine attenuates acute lung injury after burn trauma.

Burns : journal of the International Society for Burn Injuries 20050601

[Determination of ligustrazine in human plasma by high performance liquid chromatography with solid-phase extraction].

Se pu = Chinese journal of chromatography 20050501

[Effect of tetramethylpyrazine on the responses of respiration and expression of nNOS in brainstem to hypoxia in rats].

Sheng li xue bao : [Acta physiologica Sinica] 20050425

Tetramethylpyrazine inhibits ATP-activated currents in rat dorsal root ganglion neurons.

Brain research 20050408

[Effect of danshensu and ligustrazine on related genes of myocardial hypertrophy induced by angiotensin II].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20050401

Activation of apical CFTR and basolateral Ca(2+)-activated K+ channels by tetramethylpyrazine in Caco-2 cell line.

European journal of pharmacology 20050314

[Experimental study of evaluation on neuroprotective effect for tetramethylpyrazine against focal cerebral ischemic injury with diffusion-weighted magnetic resonance imaging].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20050201

[Evaluation of the efficacy of ligustrazine collaborated with magnesium sulfate in the treatment of pregnancy-induced hypertension in rats].

Shi yan sheng wu xue bao 20050201

[Effects of three Chinese traditional drugs on afferent discharge from single muscle spindle in toads].

Hang tian yi xue yu yi xue gong cheng = Space medicine & medical engineering 20050201

Antioxidative effects of tetramethylpyrazine on acute ethanol-induced lipid peroxidation.

The American journal of Chinese medicine 20050101

Enhancing effects of ligustrazine on expression of CD31 and hematopoietic reconstitution in syngenic bone marrow transplantation of mice.

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20050101

Effects of ligustrazine on the contraction of isolated rabbit corpus cavernosum strips.

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20050101

Liquid chromatography-mass spectrometry method for determination of tetramethylpyrazine and its metabolite in dog plasma.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041225

[Effect of ligustrazine on airway remodeling in asthmatic rats].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20041201

Tetramethylpyrazine reduces ischemic brain injury in rats.

Neuroscience letters 20041130

[Effects of combination therapy of rehin and tetramethylpyrazine on experimental hepatic fibrosis induced by tetrachloride].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20041101

The electrochemistry and determination of Ligustrazine hydrochloride.

Analytical and bioanalytical chemistry 20041001

[Effect of tetramethylpyrazine on lipopolysaccharides induced macrophage cyclo-oxidase-2 expression and apoptosis of cardiac myocytes].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20041001

[Protective effect of tetramethylpyrazine and L-arginine on rats with acute myocardial infarction].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20041001

[Study on ligustrazine in reversing multidrug resistance of HepG2/ADM cell in vitro].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20041001

Improvement of barrier function and stimulation of colonic epithelial anion secretion by Menoease Pills.

World journal of gastroenterology 20040901

The protective effects of ligustrazine on ischemia-reperfusion and DPPH free radical-induced myocardial injury in isolated rat hearts.

Planta medica 20040901

Protective effect of tetramethylpyrazine on learning and memory function in D-galactose-lesioned mice.

Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih 20040901

Effect of ligustrazine on ischemia-reperfusion injury in murine kidney.

Transplantation proceedings 20040901

Preparative isolation and purification of chuanxiongzine from the medicinal plant Ligusticum chuanxiong by high-speed counter-current chromatography.

Journal of chromatography. A 20040827

[Effect of chuanxiongzine on the relaxation of isolated rabbit corpus cavernosum tissues].

Zhonghua nan ke xue = National journal of andrology 20040801

[Effects of ligustrazine on expression of PECAM-1/CD31 and hematopoietic reconstitution in syngenic bone marrow transplantation of mice].

Zhongguo shi yan xue ye xue za zhi 20040801

[Experimental study on prevention and treatment of bronchial asthma by compound Chinese herbal monomer recipe].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20040801

[Study on the interactions between four components in Ligusticum chuanxiong rhizome and acceptors on cardiac muscle membrane].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20040701

Differential Cl- and HCO3- mediated anion secretion by different colonic cell types in response to tetromethylpyrazine.

World journal of gastroenterology 20040615

[The effect of ligustrazine on the expression of CD44 in bone marrow of bone marrow transplantation mice].

Zhongguo shi yan xue ye xue za zhi 20040601

[Cardiac hemodynamics after suprarenal ligation of the inferior vena cava and the resection of the right kidney or injection of ligustrazine in rats].

Ai zheng = Aizheng = Chinese journal of cancer 20040501

[Effect of ligustrazine on expressions of basic fibroblast growth factor and its receptor in bone marrow of mice with acute radiation injury].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20040501

[Effect of ligustrazine on injury of vascular endothelial cells ECV-304 induced by hypoxia and lack of glucose].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20040501

[Effect of ligustrazine on the expression of LFA-1 and ICAM-1 in bone marrow transplantation recipient mice].

Zhongguo shi yan xue ye xue za zhi 20040401

Effects of electroacupuncture plus intra-carotid drug injection on rheoencephalogram in patients with cerebral infarction.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 20040301

[Effect of Ligustrazine on the expression of vascular endothelial growth factor in bone marrow stromal cells of radiation injured mice].

Zhongguo shi yan xue ye xue za zhi 20040201

[Progress of the study on effective integredients from Chinese herbal medicine in anti-tumor metastasis].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20040201

Type two cytokines predominance of human lung cancer and its reverse by traditional Chinese medicine TTMP.

Cellular & molecular immunology 20040201

Studies on the aroma of cupuassu liquor by headspace solid-phase microextraction and gas chromatography.

Journal of chromatography. A 20040130

Effect of tetramethylpyrazine on acute nociception mediated by signaling of P2X receptor activation in rat.

Brain research 20040109

[Chemical profiles of methylpyrazines contained in commercially available natto].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20040101

Nitric oxide-mediated vasorelaxation by Rhizoma Ligustici wallichii in isolated rat thoracic aorta.

Phytomedicine : international journal of phytotherapy and phytopharmacology 20040101

Inhibition of shear-induced platelet aggregation in rat by tetramethylpyrazine and salvianolic acid B.

Clinical hemorheology and microcirculation 20040101

Effect of ligustrazine on the expression of LFA-1, ICAM-1 following bone marrow transplantation in mice.

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20040101

[Effect of tetromethylpyrazine and aminoguanidine on expression of vascular endothelial growth factor in kidney of diabetic rats].

Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20040101

Pickles, pectin, and penicillin.

Annual review of microbiology 20040101

Preparation of cardiovascular disease-related genes microarray and its application in exploring ligustrazine-induced changes in endothelial gene expression.

Polish journal of pharmacology 20040101

Inhibitory effects of ligustrazine, a modulator of thromboxane-prostacycline-nitric oxide balance, on renal injury in rats with passive Heyman nephritis.

Nephron. Physiology 20040101

The oxygen radical generator pyrogallol impairs cardiomyocyte contractile function via a superoxide and p38 MAP kinase-dependent pathway: protection by anisodamine and tetramethylpyrazine.

Cardiovascular toxicology 20040101

Basolateral membrane mechanisms involved in ligustrazine-stimulated anion secretion in rat distal colon.

Sheng li xue bao : [Acta physiologica Sinica] 20031225

[Protective effect of ligustrazine on insulin resistance after local cerebral ischemia of rat].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20031201

Effect of tetramethylpyrazine on exocrine pancreatic and bile secretion.

World journal of gastroenterology 20031115

Tetramethylpyrazine elicits disparate responses in cardiac contraction and intracellular Ca(2+) transients in isolated adult rat ventricular myocytes.

Vascular pharmacology 20031101

Effect of tetramethylpyrazine on potassium channels to lower calcium concentration in cultured aortic smooth muscle cells.

Clinical and experimental pharmacology & physiology 20031001

[Effect of tetramethylpyrazine on learning, memory and cholinergic system in D-galactose-lesioned mice].

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20031001

[Effect of ligustrazine on cell cycle and prostacyclin of injured vascular endothelial cells induced by hypoxia and lack of glucose].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20031001

[Ligustrazine and Salvia miltiorrhiza injection solution in complementary therapy of pregnancy-induced hypertension: clinical analysis of 60 cases].

Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20030901

[Effects of tetramethylpyrazine on cytosolic free calcium concentration in penis corpus cavernsum smooth muscle cells in rabbits].

Zhonghua nan ke xue = National journal of andrology 20030801

[Effect of ligustrazine on proliferative glomerulonephritis].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20030801

Effect of tetramethylpyrazine on P-selectin and hepatic/renal ischemia and reperfusion injury in rats.

World journal of gastroenterology 20030715

Synthesis of the novel liqustrazine derivatives and Their protective effect on injured vascular endothelial cell damaged by hydrogen peroxide.

Bioorganic & medicinal chemistry letters 20030707

Convolution method to predict drug concentration profiles of 2,3,5,6-tetramethylpyrazine following transdermal application.

International journal of pharmaceutics 20030618

[Comparing effect in the management of erectile dysfunction by using 2 sets of drugs of intracavernosal injection].

Zhonghua nan ke xue = National journal of andrology 20030601

Tetramethylpyrazine as potassium channel opener to lower calcium influx into cultured aortic smooth muscle cells.

Planta medica 20030601

[Effect of ligustrazine on the expression of Bcl-2 protein and apoptosis in rabbit articular chondrocytes in monolayer culture].

Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University 20030601

Mechanisms responsible for the in vitro relaxation of ligustrazine on porcine left anterior descending coronary artery.

European journal of pharmacology 20030516

[Clinical application and pharmacological actions of ligustrazine].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20030501

[Progress on TCM drug-therapy of antagonizing arteriosclerosis].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20030501

Iron-induced oxidative damage and apoptosis in cerebellar granule cells: attenuation by tetramethylpyrazine and ferulic acid.

European journal of pharmacology 20030425

AgC(CN)3-based coordination polymers.

Inorganic chemistry 20030421

Tetramethylpyrazine scavenges superoxide anion and decreases nitric oxide production in human polymorphonuclear leukocytes.

Life sciences 20030418

[Effect of tetramethylpyrazine on endothelin, von Willebrand factor and thromboxane A2 during cardiopulmonary bypass in patients of congenital heart disease with pulmonary hypertension].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20030401

[Study on the effects of tetramethylpyrazine on tumor cells: survey and prospects].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20030401

Physicochemical characterization and percutaneous delivery of 2,3,5,6-tetramethylpyrazine.

International journal of pharmaceutics 20030306

Comparative studies of LFA-1/ICAM-1 interaction by micropipette and flow chamber techniques.

Biorheology 20030101

The effects of Ligustrazine on the expression of bFGF and bFGFR in bone marrow in radiation injured mice.

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20030101

The prediction of plasma and brain levels of 2,3,5,6-tetramethylpyrazine following transdermal application.

AAPS pharmSci 20021201

In vitro permeation of tetramethylpyrazine across porcine buccal mucosa.

Acta pharmacologica Sinica 20020901

[Preparation and in vitro release of tetramethylpyrazine phosphate pulsincap capsule controlled by an erodible plug].

Yao xue xue bao = Acta pharmaceutica Sinica 20020901

Inhibitory effects of potassium channel blockers on tetramethylpyrazine-induced relaxation of rat aortic strip in vitro.

Life sciences 20020802

[Effect of tetramethylpyrazine on voltage-dependent channels in aortic smooth muscle of rat].

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20020801

Effects of various principles from Chinese herbal medicine on rhodamine123 accumulation in brain capillary endothelial cells.

Acta pharmacologica Sinica 20020701

Hepatoprotective and therapeutic effects of tetramethylpyrazine on acute econazole-induced liver injury.

Planta medica 20020601

[Effect of ligustrazine on bone marrow hematopoiesis in mice after bone marrow transplantation].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20020501

[Effects of ligustrazin on lipid peroxidation during hepatic ischemia reperfusion injury].

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20020501

Use of gas chromatography-olfactometry to identify key odorant compounds in dark chocolate. Comparison of samples before and after conching.

Journal of agricultural and food chemistry 20020410

[Cultivation of fibroblasts derived from urethral scar and the effects of salviae miltiorrhizae and ligustrazine on its growth].

Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao 20020401

Protective effects of tetramethylpyrazine on kainate-induced excitotoxicity in hippocampal culture.

Neuroreport 20020325

Studies on single-cell adhesion probability between lymphocytes and endothelial cells with micropipette technique.

Microvascular research 20020301

[Protective effect of tetramethylpyrazine on red blood cells during autotransfusion].

Zhonghua yi xue za zhi 20020301

[The intervention effects of Angelica sinensis, Salvia miltiorrhiza and ligustrazine on peritoneal macrophages during peritoneal dialysis].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20020301

[Effects of ligustrazine on blood vessels and blood components].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20020201

Tetramethylpyrazine attenuates spinal cord ischemic injury due to aortic cross-clamping in rabbits.

BMC neurology 20020101

[Expression of transcription factor T-bet/GATA3 in lung cancer patients and its interference by the traditional Chinese herbal medicine].

Zhonghua zhong liu za zhi [Chinese journal of oncology] 20020101

Protective effect of tetramethylpyrazine on absolute ethanol-induced renal toxicity in mice.

Journal of biomedical science 20020101

Protection by tetramethylpyrazine in acute absolute ethanol-induced gastric lesions.

Journal of biomedical science 20020101

Tetramethylpyrazine protects mice against thioacetamide-induced acute hepatotoxicity.

Journal of biomedical science 20020101

Protective effects of ligustrazine on ischemia-reperfusion injury in rat kidneys.

Microsurgery 20020101

Effect of tetramethylpyrazine on lipid peroxidation in streptozotocin-induced diabetic mice.

The American journal of Chinese medicine 20020101

Effects of ligustrazine on hematopoiesis in the early phase of bone marrow transplantation mice.

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20020101

The effect of ligustrazine on peritoneal transport in peritoneal dialysis.

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20020101

[Advances in the study on transdermal permeation of active elements of natural drugs in vitro].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20020101

Current studies on anti-endotoxic chemical components of traditional Chinese medicine in China.

Acta pharmacologica Sinica 20011201

[Effect of ligustrazine peritoneal dialysate on CD40 expression of rat peritoneal mesothellial cells].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20011201

Specific inhibiting characteristics of tetramethylpyrazine, one of the active ingredients of the Chinese herbal medicine 'Chuanxiong,' on platelet thrombus formation under high shear rates.

Thrombosis research 20011001

Separation and determination of ephedrine alkaloids and tetramethylpyrazine in Ephedra sinica Stapf by gas chromatography-mass spectrometry.

Journal of chromatographic science 20010901

Aqueous flare elevation induced by transcorneal application of highly selective agonists for prostaglandin E2 receptor subtypes in pigmented rabbits: effect of tetramethylpyrazine.

Prostaglandins & other lipid mediators 20010701

Effect of tetramethyl pyrazine on L-type calcium channel in rat ventricular myocytes.

Canadian journal of physiology and pharmacology 20010701

Antithrombotic effects of tetramethylpyrazine in in vivo experiments.

International journal of hematology 20010401

[Transporting into the kidney of medications injected into the renal adipose capsules of rats].

Zhonghua yi xue za zhi 20010325

Pharmacokinetics of tetramethylpyrazine in rat blood and brain using microdialysis.

International journal of pharmaceutics 20010323

[Separation and determination of ephedrine alkaloids and 2,3,5,6-tetramethyl pyrazine in Ephedra herba by HPLC].

Se pu = Chinese journal of chromatography 20010301

[Effect of combination of ligustrazine and nitrendipine on hemodynamics in patients with chronic obstructive pulmonary disease].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20010301

Effects of tetramethylpyrazine on prostaglandin E(2)- and prostaglandin E(2) receptor agonist-induced disruption of blood-aqueous barrier in pigmented rabbits.

Japanese journal of ophthalmology 20010101

Ligustrazini inhibits endotoxin induced PAI-1 expression in human umbilical vein endothelial cells.

Journal of Tongji Medical University = Tong ji yi ke da xue xue bao 20010101

Effect of ligustrazine on hematopoiesis in bone marrow transplantation mice.

Journal of Tongji Medical University = Tong ji yi ke da xue xue bao 20010101

[Therapeutic mechanism of combination therapy of ligustrazine and nitrendipine in treating patients with chronic obstructive pulmonary disease].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20010101

Effects of tetramethylpyrazine on heart rate and pupil diameter in rats.

Zhongguo yao li xue bao = Acta pharmacologica Sinica 19900901