CAS 1115-70-4 | Metformin hydrochloride | CAS Number 1115-70-4

Title	Journal
Metformin alleviated endotoxemia-induced acute lung injury via restoring AMPK-dependent suppression of mTOR.	Chemico-biological interactions 20180801
d-galactose induces premature senescence of lens epithelial cells by disturbing autophagy flux and mitochondrial functions.	Toxicology letters 20180601
Sulfenamide and sulfonamide derivatives of metformin can exert anticoagulant and profibrinolytic properties.	Chemico-biological interactions 20180325
Metformin and epothilone A treatment up regulate pro-apoptotic PARP-1, Casp-3 and H2AX genes and decrease of AKT kinase level to control cell death of human hepatocellular carcinoma and ovary adenocarcinoma cells.	Toxicology in vitro : an international journal published in association with BIBRA 20180301
Modulatory effects of metformin on mutagenicity and epithelial tumor incidence in doxorubicin-treated Drosophila melanogaster.	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20170801
Metformin and caffeic acid regulate metabolic reprogramming in human cervical carcinoma SiHa/HTB-35 cells and augment anticancer activity of Cisplatin via cell cycle regulation.	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20170801
Multidrug and toxin extrusion proteins mediate cellular transport of cadmium.	Toxicology and applied pharmacology 20170101
Lobeglitazone, a Novel Thiazolidinedione, Improves Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes: Its Efficacy and Predictive Factors Related to Responsiveness.	Journal of Korean medical science 20170101
Editor's Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction.	Toxicological sciences : an official journal of the Society of Toxicology 20161201
Effect of canagliflozin and metformin on cortical neurotransmitters in a diabetic rat model.	Chemico-biological interactions 20161025
Metformin Improves Metabolic Memory in High Fat Diet (HFD)-induced Renal Dysfunction.	The Journal of biological chemistry 20161014
Organic Cation Transporter 2 Overexpression May Confer an Increased Risk of Gentamicin-Induced Nephrotoxicity.	Antimicrobial agents and chemotherapy 20160901
Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin.	Nature genetics 20160901
Sodium butyrate reduces insulin-resistance, fat accumulation and dyslipidemia in type-2 diabetic rat: A comparative study with metformin.	Chemico-biological interactions 20160725
Efficacy, safety, and tolerability of ipragliflozin in Asian patients with type 2 diabetes mellitus and inadequate glycemic control with metformin: Results of a phase 3 randomized, placebo-controlled, double-blind, multicenter trial.	Journal of diabetes investigation 20160501
Metformin administration induces hepatotoxic effects in paraoxonase-1-deficient mice.	Chemico-biological interactions 20160405
Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro.	Toxicology letters 20160105
Metformin prevents cancer metastasis by inhibiting M2-like polarization of tumor associated macrophages.	Oncotarget 20151103
Preventing Allograft Rejection by Targeting Immune Metabolism.	Cell reports 20151027
Effective impairment of myeloma cells and their progenitors by blockade of monocarboxylate transportation.	Oncotarget 20151020
Specificity protein (Sp) transcription factors and metformin regulate expression of the long non-coding RNA HULC.	Oncotarget 20150922
Lobeglitazone and pioglitazone as add-ons to metformin for patients with type 2 diabetes: a 24-week, multicentre, randomized, double-blind, parallel-group, active-controlled, phase III clinical trial with a 28-week extension.	Diabetes, obesity & metabolism 20150601
Metformin inhibits 7,12-dimethylbenz[a]anthracene-induced breast carcinogenesis and adduct formation in human breast cells by inhibiting the cytochrome P4501A1/aryl hydrocarbon receptor signaling pathway.	Toxicology and applied pharmacology 20150415
Orotic acid induces hypertension associated with impaired endothelial nitric oxide synthesis.	Toxicological sciences : an official journal of the Society of Toxicology 20150401
Metformin aggravates immune-mediated liver injury in mice.	Archives of toxicology 20150301
Metformin Attenuates Testosterone-Induced Prostatic Hyperplasia in Rats: A Pharmacological Perspective.	Scientific reports 20150101
Pharmacological activation of AMPK ameliorates perivascular adipose/endothelial dysfunction in a manner interdependent on AMPK and SIRT1.	Pharmacological research 20141101
Metformin suppresses CYP1A1 and CYP1B1 expression in breast cancer cells by down-regulating aryl hydrocarbon receptor expression.	Toxicology and applied pharmacology 20141001
Chronic treatment with metformin suppresses toll-like receptor 4 signaling and attenuates left ventricular dysfunction following myocardial infarction.	European journal of pharmacology 20140815
Metformin inhibits hepatitis B virus protein production and replication in human hepatoma cells.	Journal of viral hepatitis 20140801
A phase II, randomized, placebo-controlled, double-blind, multi-dose study of SRT2104, a SIRT1 activator, in subjects with type 2 diabetes.	British journal of clinical pharmacology 20140701
Metformin protects against seizures, learning and memory impairments and oxidative damage induced by pentylenetetrazole-induced kindling in mice.	Biochemical and biophysical research communications 20140613
Involvement of catalase in the protective benefits of metformin in mice with oxidative liver injury.	Chemico-biological interactions 20140605
Empagliflozin as add-on to metformin in patients with type 2 diabetes: a 24-week, randomized, double-blind, placebo-controlled trial.	Diabetes care 20140601
Metformin induces PGC-1α expression and selectively affects hepatic PGC-1α functions.	British journal of pharmacology 20140501
Ondansetron can enhance cisplatin-induced nephrotoxicity via inhibition of multiple toxin and extrusion proteins (MATEs).	Toxicology and applied pharmacology 20131115
Metformin inhibits heme oxygenase-1 expression in cancer cells through inactivation of Raf-ERK-Nrf2 signaling and AMPK-independent pathways.	Toxicology and applied pharmacology 20130901
Transfer of metformin across the rat placenta is mediated by organic cation transporter 3 (OCT3/SLC22A3) and multidrug and toxin extrusion 1 (MATE1/SLC47A1) protein.	Reproductive toxicology (Elmsford, N.Y.) 20130801
Visfatin is expressed in human granulosa cells: regulation by metformin through AMPK/SIRT1 pathways and its role in steroidogenesis.	Molecular human reproduction 20130501
Prenatal metformin exposure in mice programs the metabolic phenotype of the offspring during a high fat diet at adulthood.	PloS one 20130101
Miniaturized ionophore-based potentiometric sensors for the flow-injection determination of metformin in pharmaceutical formulations and biological fluids.	The Analyst 20121207
Metformin use is associated with a decreased incidence of colorectal adenomas in diabetic patients with previous colorectal cancer.	Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20121201
Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling.	Aging 20121201
Type of preadmission antidiabetic treatment and outcome among patients with ischemic stroke: a nationwide follow-up study.	Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 20121101
Population PK/PD analysis of metformin using the signal transduction model.	British journal of clinical pharmacology 20121101
Differential effects of 3 classes of antidiabetic drugs on olanzapine-induced glucose dysregulation and insulin resistance in female rats.	Journal of psychiatry & neuroscience : JPN 20121101
Time to failure of oral therapy in children with type 2 diabetes: a single center retrospective chart review.	Pediatric diabetes 20121101
Dapagliflozin has no effect on markers of bone formation and resorption or bone mineral density in patients with inadequately controlled type 2 diabetes mellitus on metformin.	Diabetes, obesity & metabolism 20121101
Metformin pathways: pharmacokinetics and pharmacodynamics.	Pharmacogenetics and genomics 20121101
The effect of metformin on insulin resistance and exercise parameters in patients with heart failure.	European journal of heart failure 20121101
Metformin exposure affects human and mouse fetal testicular cells.	Human reproduction (Oxford, England) 20121101
Patient education on the benefit and risks of medications goes beyond metformin.	Diabetic medicine : a journal of the British Diabetic Association 20121101
Binding studies of the antidiabetic drug, metformin to calf thymus DNA using multispectroscopic methods.	Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20121101
Metformin targets ovarian cancer stem cells in vitro and in vivo.	Gynecologic oncology 20121101
A high-fat-diet-induced cognitive deficit in rats that is not prevented by improving insulin sensitivity with metformin.	Diabetologia 20121101
Health-related quality of life in women with newly diagnosed polycystic ovary syndrome randomized between clomifene citrate plus metformin or clomifene citrate plus placebo.	Human reproduction (Oxford, England) 20121101
Growth, body composition and metabolic profile of 8-year-old children exposed to metformin in utero.	Scandinavian journal of clinical and laboratory investigation 20121101
Metformin does not alter the risk of lung cancer: a case-control analysis.	Lung cancer (Amsterdam, Netherlands) 20121101
Metformin affects the circadian clock and metabolic rhythms in a tissue-specific manner.	Biochimica et biophysica acta 20121101
Associations of type 2 diabetes and diabetes treatment with breast cancer risk and mortality: a population-based cohort study among British women.	Cancer causes & control : CCC 20121101
Effects of metformin on insulin resistance in heart failure. Which came first: the chicken or the egg?	European journal of heart failure 20121101
Metformin's effect on first-year weight gain: a follow-up study.	Pediatrics 20121101
Fitness, fatness, and metformin.	Medicine and science in sports and exercise 20121101
Orphan nuclear receptor small heterodimer partner negatively regulates growth hormone-mediated induction of hepatic gluconeogenesis through inhibition of signal transducer and activator of transcription 5 (STAT5) transactivation.	The Journal of biological chemistry 20121026
AMP-activated protein kinase: a target for drugs both ancient and modern.	Chemistry & biology 20121026
Central anti-diabetic action of biguanide and thizolidinediones in D-glucose fed and streptozotocin-treated mouse models.	Neuroscience letters 20121018
Long versus short course treatment with metformin and clomiphene citrate for ovulation induction in women with PCOS.	The Cochrane database of systematic reviews 20121017
Removal of charged micropollutants from water by ion-exchange polymers -- effects of competing electrolytes.	Water research 20121015
Molecular mechanisms of lipoapoptosis and metformin protection in GLP-1 secreting cells.	Biochemical and biophysical research communications 20121012
AMP-activated protein kinase stimulates myostatin expression in C2C12 cells.	Biochemical and biophysical research communications 20121012
Effects of metformin on learning and memory behaviors and brain mitochondrial functions in high fat diet induced insulin resistant rats.	Life sciences 20121005
TAp63 is a master transcriptional regulator of lipid and glucose metabolism.	Cell metabolism 20121003
Determination of metformin in rat plasma by HILIC-MS/MS combined with Tecan automation and direct injection.	Biomedical chromatography : BMC 20121001
[Metformin associates lactic acidosis].	Presse medicale (Paris, France : 1983) 20121001
Strict glycaemic control improves skin microcirculation in patients with type 2 diabetes: a report from the Diabetes mellitus And Diastolic Dysfunction (DADD) study.	Diabetes & vascular disease research 20121001
Fatty acids revert the inhibition of respiration caused by the antidiabetic drug metformin to facilitate their mitochondrial β-oxidation.	Biochimica et biophysica acta 20121001
Effect of metformin and spironolactone therapy on OGTT in patients with polycystic ovarian syndrome - a retrospective analysis.	Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20121001
A primary care register for impaired glucose handling (IGH): impact on cardiometabolic profile.	Primary care diabetes 20121001
Metformin therapy in patients with chronic kidney disease.	Diabetes, obesity & metabolism 20121001
Efficacy and safety of alogliptin added to metformin in Japanese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial with an open-label, long-term extension study.	Diabetes, obesity & metabolism 20121001
A randomized controlled trial of an intensive insulin regimen in patients with hyperglycemic acute lymphoblastic leukemia.	Clinical lymphoma, myeloma & leukemia 20121001
Effects of a combination of sitagliptin plus metformin vs metformin monotherapy on glycemic control, β-cell function and insulin resistance in type 2 diabetic patients.	Diabetes research and clinical practice 20121001
Reduction of oxidative stress and inflammation by blunting daily acute glucose fluctuations in patients with type 2 diabetes: role of dipeptidyl peptidase-IV inhibition.	Diabetes care 20121001
Metformin inhibits growth hormone-mediated hepatic PDK4 gene expression through induction of orphan nuclear receptor small heterodimer partner.	Diabetes 20121001
Metformin impairs the growth of liver kinase B1-intact cervical cancer cells.	Gynecologic oncology 20121001
Occurrence and fate of the antidiabetic drug metformin and its metabolite guanylurea in the environment and during drinking water treatment.	Water research 20121001
Add-on therapies to metformin in type 2 diabetes: what modulates the respective decrements in postprandial and basal glucose?	Diabetes technology & therapeutics 20121001
Is there a dose-response relationship of metformin treatment in patients with polycystic ovary syndrome? Results from a multicentric study.	Human reproduction (Oxford, England) 20121001
Ethinyl estradiol-cyproterone acetate versus low-dose pioglitazone-flutamide-metformin for adolescent girls with androgen excess: divergent effects on CD163, TWEAK receptor, ANGPTL4, and LEPTIN expression in subcutaneous adipose tissue.	The Journal of clinical endocrinology and metabolism 20121001
Effect of insulin versus triple oral therapy on the progression of hepatic steatosis in type 2 diabetes.	Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20121001
Different antidiabetic regimens and the development of renal dysfunction in US Veterans with type 2 diabetes mellitus.	Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20121001
Continuous glucose profiles with vildagliptin versus sitagliptin in add-on to metformin: results from the randomized Optima study.	Diabetes & metabolism 20121001
Enhanced cytotoxic effect of low doses of metformin combined with ionizing radiation on hepatoma cells via ATP deprivation and inhibition of DNA repair.	Oncology reports 20121001
Diabetes and pancreatic cancer.	Endocrine-related cancer 20121001
Metformin and breast cancer risk: a meta-analysis and critical literature review.	Breast cancer research and treatment 20121001
Cancer outcomes and all-cause mortality in adults allocated to metformin: systematic review and collaborative meta-analysis of randomised clinical trials.	Diabetologia 20121001
Diabetes: Add-on to metformin in T2DM--linagliptin or glimepiride?	Nature reviews. Endocrinology 20121001
Metformin in early breast cancer: a prospective window of opportunity neoadjuvant study.	Breast cancer research and treatment 20121001
Rejuvenating regeneration: metformin activates endogenous adult stem cells.	Cell cycle (Georgetown, Tex.) 20121001
Status of clomiphene citrate and metformin for infertility in PCOS.	Trends in endocrinology and metabolism: TEM 20121001
Metformin for schizophrenia: an editorial comment to Curtis J, Newall H, Shiers D, Samaras K. 'Considering metformin in cardiometabolic protection in psychosis'.	Acta psychiatrica Scandinavica 20121001
Patterns of medication initiation in newly diagnosed diabetes mellitus: quality and cost implications.	The American journal of medicine 20121001
Insulin sensitization therapy and the heart: focus on metformin and thiazolidinediones.	Heart failure clinics 20121001
Cost-utility analysis of liraglutide versus glimepiride as add-on to metformin in type 2 diabetes patients in China.	International journal of technology assessment in health care 20121001
Effects of saxagliptin added to sub-maximal doses of metformin compared with uptitration of metformin in type 2 diabetes: the PROMPT study.	Current medical research and opinion 20121001
Safety of exenatide once weekly in patients with type 2 diabetes mellitus treated with a thiazolidinedione alone or in combination with metformin for 2 years.	Clinical therapeutics 20121001
Chemerin and apelin are positively correlated with inflammation in obese type 2 diabetic patients.	Chinese medical journal 20121001
[Continuous glucose monitoring in glimipiride plus metformin treated type 2 diabetic patients during the month of Ramadan].	La Tunisie medicale 20121001
[Proposal for the modification of metformin use in patients with chronic kidney disease].	Orvosi hetilap 20120930
What's preventing us from preventing type 2 diabetes?	The New England journal of medicine 20120927
Cerulein hyperstimulation decreases AMP-activated protein kinase levels at the site of maximal zymogen activation.	American journal of physiology. Gastrointestinal and liver physiology 20120915
Glycemic control in youth with type 2 diabetes.	The New England journal of medicine 20120913
Linagliptin: a review of its use in the management of type 2 diabetes mellitus.	Drugs 20120910
Metformin inhibits inflammatory response via AMPK-PTEN pathway in vascular smooth muscle cells.	Biochemical and biophysical research communications 20120907
Addition of liraglutide in patients with Type 2 diabetes well controlled on metformin monotherapy improves several markers of vascular function.	Diabetic medicine : a journal of the British Diabetic Association 20120901
Metformin decreases plasma resistin concentrations in pediatric patients with impaired glucose tolerance: a placebo-controlled randomized clinical trial.	Metabolism: clinical and experimental 20120901
Increase in overall mortality risk in patients with type 2 diabetes receiving glipizide, glyburide or glimepiride monotherapy versus metformin: a retrospective analysis.	Diabetes, obesity & metabolism 20120901
Effect of antidiabetic agents added to metformin on glycaemic control, hypoglycaemia and weight change in patients with type 2 diabetes: a network meta-analysis.	Diabetes, obesity & metabolism 20120901
Imeglimin, a novel glimin oral antidiabetic, exhibits a good efficacy and safety profile in type 2 diabetic patients.	Diabetes, obesity & metabolism 20120901
Metformin preconditioning protects Daphnia pulex from lethal hypoxic insult involving AMPK, HIF and mTOR signaling.	Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20120901
Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats.	Pharmacological research 20120901
Metformin interacts with AMPK through binding to γ subunit.	Molecular and cellular biochemistry 20120901
Inhibition of complex I regulates the mitochondrial permeability transition through a phosphate-sensitive inhibitory site masked by cyclophilin D.	Biochimica et biophysica acta 20120901
The addition of sitagliptin to ongoing metformin therapy significantly improves glycemic control in Chinese patients with type 2 diabetes.	Journal of diabetes 20120901
Interaction of the cardiovascular risk marker asymmetric dimethylarginine (ADMA) with the human cationic amino acid transporter 1 (CAT1).	Journal of molecular and cellular cardiology 20120901
Metformin reverses hexokinase and phosphofructokinase downregulation and intracellular distribution in the heart of diabetic mice.	IUBMB life 20120901
Effects of frequency of follow-up on quality of life of type 2 diabetes patients on oral hypoglycemics.	Diabetes technology & therapeutics 20120901
Association of genetic variation in the organic cation transporters OCT1, OCT2 and multidrug and toxin extrusion 1 transporter protein genes with the gastrointestinal side effects and lower BMI in metformin-treated type 2 diabetes patients.	Pharmacogenetics and genomics 20120901
The C allele of ATM rs11212617 does not associate with metformin response in the Diabetes Prevention Program.	Diabetes care 20120901
Metformin inhibits the development and metastasis of ovarian cancer.	Oncology reports 20120901
Recommendations for diagnosis and management of metformin-induced vitamin B12 (Cbl) deficiency.	Diabetes research and clinical practice 20120901
Diabetes, metformin use, and colon cancer: a population-based cohort study in Taiwan.	European journal of endocrinology 20120901
Metformin inhibits human androgen production by regulating steroidogenic enzymes HSD3B2 and CYP17A1 and complex I activity of the respiratory chain.	Endocrinology 20120901
Abnormal glucose metabolism: diagnosis and management in the ambulatory setting.	Clinical obstetrics and gynecology 20120901
Viewpoint: Central adjudication of myocardial infarction in outcome-driven clinical trials--common patterns in TRITON, RECORD, and PLATO?	Thrombosis and haemostasis 20120901
Targeting the consequences of the metabolic syndrome in the Diabetes Prevention Program.	Arteriosclerosis, thrombosis, and vascular biology 20120901
Investigating metformin for cancer prevention and treatment: the end of the beginning.	Cancer discovery 20120901
AMP-activated protein kinase acts as a negative regulator of high glucose-induced RANKL expression in human periodontal ligament cells.	Chinese medical journal 20120901
Comparative efficacy of thiazolidinediones and metformin for polycystic ovary syndrome.	Saudi medical journal 20120901
A report of the James Watson lecture at Yale University.	The Yale journal of biology and medicine 20120901
Early, aggressive treatment is effective in treating diabetes. Risk of long-term complications reduced significantly.	DukeMedicine healthnews 20120901
Momordica charantia for type 2 diabetes mellitus.	The Cochrane database of systematic reviews 20120815
Diabetes, metformin, and breast cancer in postmenopausal women.	Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120810
Diabetes, metformin, and breast cancer: lilac time?	Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120810
Gliptin versus a sulphonylurea as add-on to metformin.	Lancet (London, England) 20120804
2-year efficacy and safety of linagliptin compared with glimepiride in patients with type 2 diabetes inadequately controlled on metformin: a randomised, double-blind, non-inferiority trial.	Lancet (London, England) 20120804
The effects of metformin on the survival of colorectal cancer patients with diabetes mellitus.	International journal of cancer 20120801
Factors predicting therapeutic efficacy of combination treatment with sitagliptin and metformin in type 2 diabetic patients: the COSMETIC study.	Clinical endocrinology 20120801
Evaluation of dibutyrylchitin as new excipient for sustained drug release.	Drug development and industrial pharmacy 20120801
A case of hypoglycemic hemiparesis and literature review.	Upsala journal of medical sciences 20120801
The risk of overall mortality in patients with Type 2 diabetes receiving different combinations of sulfonylureas and metformin: a retrospective analysis.	Diabetic medicine : a journal of the British Diabetic Association 20120801
Determinants of glycemic control in youth with type 2 diabetes at randomization in the TODAY study.	Pediatric diabetes 20120801
The effect of linagliptin on glycaemic control and tolerability in patients with type 2 diabetes mellitus: a systematic review and meta-analysis.	Diabetes, obesity & metabolism 20120801
Glucose-lowering treatment and clinical results in 163 121 patients with type 2 diabetes: an observational study from the Swedish national diabetes register.	Diabetes, obesity & metabolism 20120801
Metformin monotherapy in youth with recent onset type 2 diabetes: experience from the prerandomization run-in phase of the TODAY study.	Pediatric diabetes 20120801
Efficacy and tolerability of vildagliptin as add-on therapy to metformin in Chinese patients with type 2 diabetes mellitus.	Diabetes, obesity & metabolism 20120801
Relation between diabetes, metformin treatment and the occurrence of malignancies in a Belgian primary care setting.	Diabetes research and clinical practice 20120801
The influence of antidiabetic medications on the development and progression of prostate cancer.	Cancer epidemiology 20120801
Downregulation of chemerin and alleviation of endoplasmic reticulum stress by metformin in adipose tissue of rats.	Diabetes research and clinical practice 20120801
Effect of lifestyle modification and metformin therapy on emerging cardiovascular risk factors in overweight Indian women with polycystic ovary syndrome.	Metabolic syndrome and related disorders 20120801
Effects of chronic treatment with metformin on dipeptidyl peptidase-4 activity, glucagon-like peptide 1 and ghrelin in obese patients with Type 2 diabetes mellitus.	Diabetic medicine : a journal of the British Diabetic Association 20120801
Links among type 2 diabetes, cancer and metformin use: what have we learned?	Diabetes research and clinical practice 20120801
Metformin sensitizes endometrial cancer cells to chemotherapy by repressing glyoxalase I expression.	The journal of obstetrics and gynaecology research 20120801
A potential mechanism of metformin-mediated regulation of glucose homeostasis: inhibition of Thioredoxin-interacting protein (Txnip) gene expression.	Cellular signalling 20120801
Cancer risk in type 2 diabetes.	Current diabetes reports 20120801
Effects of metformin on the expression of GLUT4 in endometrium of obese women with polycystic ovary syndrome.	Biology of reproduction 20120801
Methazolamide is a new hepatic insulin sensitizer that lowers blood glucose in vivo.	Diabetes 20120801
Cardioprotective effects of metformin and vildagliptin in adult rats with insulin resistance induced by a high-fat diet.	Endocrinology 20120801
The treatment of infertility in polycystic ovary syndrome: a brief update.	The Australian & New Zealand journal of obstetrics & gynaecology 20120801
Thyreotropin levels in diabetic patients on metformin treatment.	European journal of endocrinology 20120801
In vitro and in vivo evaluation of a sulfenamide prodrug of basic metformin.	Journal of pharmaceutical sciences 20120801
Comparison of a soluble co-formulation of insulin degludec/insulin aspart vs biphasic insulin aspart 30 in type 2 diabetes: a randomised trial.	European journal of endocrinology 20120801
Inhibition of TNF-α improves the bladder dysfunction that is associated with type 2 diabetes.	Diabetes 20120801
Lower risk of hypoglycemia with sitagliptin compared to glipizide when either is added to metformin therapy: a pre-specified analysis adjusting for the most recently measured HbA(1c) value.	Current medical research and opinion 20120801
Metformin for treatment of antipsychotic-induced amenorrhea and weight gain in women with first-episode schizophrenia: a double-blind, randomized, placebo-controlled study.	The American journal of psychiatry 20120801
Insulin resistance in type 2 diabetic youth.	Current opinion in endocrinology, diabetes, and obesity 20120801
A single-dose, crossover study comparing the pharmacokinetics and pharmacodynamics of 2 formulations of metformin in healthy volunteers.	International journal of clinical pharmacology and therapeutics 20120801
Overview of metformin: special focus on metformin extended release.	Expert opinion on pharmacotherapy 20120801
Combination treatment with ipragliflozin and metformin: a randomized, double-blind, placebo-controlled study in patients with type 2 diabetes mellitus.	Clinical therapeutics 20120801
Metformin is synthetically lethal with glucose withdrawal in cancer cells.	Cell cycle (Georgetown, Tex.) 20120801
Metformin is synthetically lethal with glucose withdrawal in cancer cells.	Cell cycle (Georgetown, Tex.) 20120801
Pregestational diabetes with extreme insulin resistance: use of U-500 insulin in pregnancy.	Obstetrics and gynecology 20120801
Severe hyperandrogenemia and insulin resistance in a 12-year-old girl.	Journal of pediatric and adolescent gynecology 20120801
Metformin as a treatment for antipsychotic drug side effects: special focus on women with schizophrenia.	The American journal of psychiatry 20120801
HbA1C - overall glycemia marker and hemolytic anemia indicator.	Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina 20120801
Efficacy and tolerability of exenatide monotherapy in obese patients with newly diagnosed type 2 diabetes: a randomized, 26 weeks metformin-controlled, parallel-group study.	Chinese medical journal 20120801
Genetic modulation of lipid profiles following lifestyle modification or metformin treatment: the Diabetes Prevention Program.	PLoS genetics 20120801
What comes after metformin for type 2 diabetes.	The Medical letter on drugs and therapeutics 20120723
Dual effect of metformin on breast cancer proliferation in a randomized presurgical trial.	Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120720
Metformin: a diabetes drug for cancer, or a cancer drug for diabetics?	Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120720
Cracking open window of opportunity trials.	Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120720
Antidiabetic II drug metformin in plants: uptake and translocation to edible parts of cereals, oily seeds, beans, tomato, squash, carrots, and potatoes.	Journal of agricultural and food chemistry 20120718
Illuminating the diabetes-cancer link.	Journal of the National Cancer Institute 20120718
Decoupling the role of image size and calorie intake on gastric retention of swelling-based gastric retentive formulations: pre-screening in the dog model.	International journal of pharmaceutics 20120715
Cardiopulmonary and endothelial effects of metformin treatment in an insulin resistant population.	International journal of cardiology 20120712
Risk identification and interventions to prevent type 2 diabetes in adults at high risk: summary of NICE guidance.	BMJ (Clinical research ed.) 20120712
An old drug for new ideas: metformin promotes adult neurogenesis and spatial memory formation.	Cell stem cell 20120706
Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation.	Cell stem cell 20120706
Untuning the tumor metabolic machine: Targeting cancer metabolism: a bedside lesson.	Nature medicine 20120706
Oral pharmacologic treatment of type 2 diabetes mellitus.	Annals of internal medicine 20120703
Oral pharmacologic treatment of type 2 diabetes mellitus.	Annals of internal medicine 20120703
Oral pharmacologic treatment of type 2 diabetes mellitus.	Annals of internal medicine 20120703
The burden of hospitalization related to diabetes mellitus: a population-based study.	Nutrition, metabolism, and cardiovascular diseases : NMCD 20120701
Cost-effectiveness of saxagliptin (Onglyza®) in type 2 diabetes in Sweden.	Primary care diabetes 20120701
Metformin and thiazolidinediones are associated with improved breast cancer-specific survival of diabetic women with HER2+ breast cancer.	Annals of oncology : official journal of the European Society for Medical Oncology 20120701
Cost and clinical implications of diabetes prevention in an Australian setting: a long-term modeling analysis.	Primary care diabetes 20120701
Sitagliptin promotes macrophage-to-faeces reverse cholesterol transport through reduced intestinal cholesterol absorption in obese insulin resistant CETP-apoB100 transgenic mice.	Diabetes, obesity & metabolism 20120701
A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells.	American journal of physiology. Cell physiology 20120701
Fasting plasma glucose 6-12 weeks after starting insulin glargine predicts likelihood of treatment success: a pooled analysis.	Diabetic medicine : a journal of the British Diabetic Association 20120701
Metformin, metabolic stress, and mitochondria. Focus on 'A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells'.	American journal of physiology. Cell physiology 20120701
A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts.	Diabetologia 20120701
Metformin-inclusive sulfonylurea therapy reduces the risk of Parkinson's disease occurring with Type 2 diabetes in a Taiwanese population cohort.	Parkinsonism & related disorders 20120701
Use of thiazolidinedione and cancer risk in Type 2 diabetes: the Hong Kong diabetes registry.	Diabetes research and clinical practice 20120701
The effect of sitagliptin versus glibenclamide on arterial stiffness, blood pressure, lipids, and inflammation in type 2 diabetes mellitus patients.	Diabetes technology & therapeutics 20120701
Metformin for liver cancer prevention in patients with type 2 diabetes: a systematic review and meta-analysis.	The Journal of clinical endocrinology and metabolism 20120701
Metformin-based treatment for obesity-related hypertension: a randomized, double-blind, placebo-controlled trial.	Journal of hypertension 20120701
Metformin protects against the development of fructose-induced steatosis in mice: role of the intestinal barrier function.	Laboratory investigation; a journal of technical methods and pathology 20120701
Diabetes and cancer II: role of diabetes medications and influence of shared risk factors.	Cancer causes & control : CCC 20120701
Efficacy and safety of taspoglutide in patients with type 2 diabetes inadequately controlled with metformin plus pioglitazone over 24 weeks: T-Emerge 3 trial.	The Journal of clinical endocrinology and metabolism 20120701
Effect of canagliflozin, a sodium glucose co-transporter 2 (SGLT2) inhibitor, on bacteriuria and urinary tract infection in subjects with type 2 diabetes enrolled in a 12-week, phase 2 study.	Current medical research and opinion 20120701
Antiproliferative action of metformin in human lung cancer cell lines.	Oncology reports 20120701
Sequential intensification of metformin treatment in type 2 diabetes with liraglutide followed by randomized addition of basal insulin prompted by A1C targets.	Diabetes care 20120701
Identification of anti-melanogenic natural compounds from Galega officinalis and further drug repositioning.	Journal of dermatological science 20120701
Metformin: direct inhibition of rat ovarian theca-interstitial cell proliferation.	Fertility and sterility 20120701
Drug-induced hypoglycaemia in type 2 diabetes.	Expert opinion on drug safety 20120701
Assessment of the pharmacokinetics of co-administered metformin and lobeglitazone, a thiazolidinedione antihyperglycemic agent, in healthy subjects.	Current medical research and opinion 20120701
Protective effect of metformin on periapical lesions in rats by decreasing the ratio of receptor activator of nuclear factor kappa B ligand/osteoprotegerin.	Journal of endodontics 20120701
β-cell function preservation after 3.5 years of intensive diabetes therapy.	Diabetes care 20120701
Liver fat is reduced by an isoenergetic MUFA diet in a controlled randomized study in type 2 diabetic patients.	Diabetes care 20120701
Metabolomic fingerprint reveals that metformin impairs one-carbon metabolism in a manner similar to the antifolate class of chemotherapy drugs.	Aging 20120701
Metformin, but not glimepiride, improves carotid artery diameter and blood flow in patients with type 2 diabetes mellitus.	Clinics (Sao Paulo, Brazil) 20120701
Initial combination therapy with metformin plus colesevelam in drug-naïve Hispanic patients with early type 2 diabetes.	Postgraduate medicine 20120701
The link between polycystic ovarian syndrome and type 2 diabetes: preventive and therapeutic approach in Israel.	The Israel Medical Association journal : IMAJ 20120701
[Basal insulin and GLP-1 agonist potentiate each other (interview by Dr. med Dirk Einecke)].	MMW Fortschritte der Medizin 20120628
Diabetes: insulin plus metformin for T2DM--are there benefits?	Nature reviews. Endocrinology 20120626
[AMPK: a novel target controlling inflammation].	Sheng li xue bao : [Acta physiologica Sinica] 20120625
Insulin glargine versus sitagliptin in insulin-naive patients with type 2 diabetes mellitus uncontrolled on metformin (EASIE): a multicentre, randomised open-label trial.	Lancet (London, England) 20120616
Choosing a blood-glucose-lowering agent after metformin.	Lancet (London, England) 20120616
Exenatide twice daily versus glimepiride for prevention of glycaemic deterioration in patients with type 2 diabetes with metformin failure (EUREXA): an open-label, randomised controlled trial.	Lancet (London, England) 20120616
Differential impact of structurally different anti-diabetic drugs on proliferation and chemosensitivity of acute lymphoblastic leukemia cells.	Cell cycle (Georgetown, Tex.) 20120615
A clinical trial to maintain glycemic control in youth with type 2 diabetes.	The New England journal of medicine 20120614
TODAY--a stark glimpse of tomorrow.	The New England journal of medicine 20120614
Defining the contribution of AMP-activated protein kinase (AMPK) and protein kinase C (PKC) in regulation of glucose uptake by metformin in skeletal muscle cells.	The Journal of biological chemistry 20120608
Metformin induces differentiation in acute promyelocytic leukemia by activating the MEK/ERK signaling pathway.	Biochemical and biophysical research communications 20120608
[Metformin associated with lactic acidosis in treatment of type 2 diabetes].	Ugeskrift for laeger 20120604
[Metformin-associated lactic acidosis can be treated with continuous renal replacement therapy].	Ugeskrift for laeger 20120604
[Treatment of metformin-associated lactate acidosis by haemodialysis].	Ugeskrift for laeger 20120604
Familial diabetes is associated with reduced risk of cancer in diabetic patients: a possible role for metformin.	Medical oncology (Northwood, London, England) 20120601
Metformin and cancer: new applications for an old drug.	Medical oncology (Northwood, London, England) 20120601
Metformin-associated lactic acidosis in a patient with normal kidney function.	Diabetes research and clinical practice 20120601
Myo-inositol may prevent gestational diabetes in PCOS women.	Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20120601
The increased dipeptidyl peptidase-4 activity is not counteracted by optimized glucose control in type 2 diabetes, but is lower in metformin-treated patients.	Diabetes, obesity & metabolism 20120601
Fenugreek attenuation of diabetic nephropathy in alloxan-diabetic rats: attenuation of diabetic nephropathy in rats.	Journal of physiology and biochemistry 20120601
Loss of multidrug and toxin extrusion 1 (MATE1) is associated with metformin-induced lactic acidosis.	British journal of pharmacology 20120601
Effect of antiandrogen treatment on bone density and bone geometry in adolescents with polycystic ovary syndrome.	Journal of pediatric and adolescent gynecology 20120601
Population pharmacokinetics of metformin in obese and non-obese patients with type 2 diabetes mellitus.	European journal of clinical pharmacology 20120601
Persistence with oral contraceptive pills versus metformin in women with polycystic ovary syndrome.	Journal of women's health (2002) 20120601
Metformin in cancer: translational challenges.	Journal of molecular endocrinology 20120601
Initial combination of linagliptin and metformin improves glycaemic control in type 2 diabetes: a randomized, double-blind, placebo-controlled study.	Diabetes, obesity & metabolism 20120601
Intensifying insulin therapy with insulin analog premixes: transitioning from basal insulin in type 2 diabetes.	Diabetes technology & therapeutics 20120601
Pregnancy outcomes and the effect of metformin treatment in women with polycystic ovary syndrome: an overview.	Acta obstetricia et gynecologica Scandinavica 20120601
Metformin inhibits growth and decreases resistance to anoikis in medullary thyroid cancer cells.	Endocrine-related cancer 20120601
AMP-activated protein kinase, stress responses and cardiovascular diseases.	Clinical science (London, England : 1979) 20120601
Combination therapy with metformin plus vildagliptin in type 2 diabetes mellitus.	Expert opinion on pharmacotherapy 20120601
Metformin for treatment of antipsychotic-induced weight gain: a randomized, placebo-controlled study.	Schizophrenia research 20120601
Metformin use among individuals at risk for type 2 diabetes.	Current diabetes reports 20120601
Ablation of both organic cation transporter (OCT)1 and OCT2 alters metformin pharmacokinetics but has no effect on tissue drug exposure and pharmacodynamics.	Drug metabolism and disposition: the biological fate of chemicals 20120601
Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice.	Pharmacology, biochemistry, and behavior 20120601
Atypical protein kinase C in cardiometabolic abnormalities.	Current opinion in lipidology 20120601
Determination of drug toxicity using 3D spheroids constructed from an immortal human hepatocyte cell line.	Toxicological sciences : an official journal of the Society of Toxicology 20120601
Luteinizing hormone facilitates angiogenesis in ovarian epithelial tumor cells and metformin inhibits the effect through the mTOR signaling pathway.	Oncology reports 20120601
Drug interactions with oral antidiabetic agents: pharmacokinetic mechanisms and clinical implications.	Trends in pharmacological sciences 20120601
Microvascular diseases: is a new era coming?	Cardiovascular & hematological agents in medicinal chemistry 20120601
The effect of metformin on the efficacy of antiviral therapy in patients with genotype 1 chronic hepatitis C and insulin resistance.	International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20120601
The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association.	Hepatology (Baltimore, Md.) 20120601
Cellular responses to the metal-binding properties of metformin.	Diabetes 20120601
Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to metformin in subjects with type 2 diabetes.	Diabetes care 20120601
Protein-tyrosine phosphatases are involved in interferon resistance associated with insulin resistance in HepG2 cells and obese mice.	The Journal of biological chemistry 20120601
Vildagliptin added to metformin on β-cell function after a euglycemic hyperinsulinemic and hyperglycemic clamp in type 2 diabetes patients.	Diabetes technology & therapeutics 20120601
The gonadal hormone regulates the plasma lactate levels in type 2 diabetes treated with and without metformin.	Diabetes technology & therapeutics 20120601
The role of combination therapy in type 2 diabetes in the post-ACCORD era.	Current diabetes reports 20120601
Inappropriate metformin prescribing in elderly type 2 diabetes mellitus (T2DM) patients.	Advances in medical sciences 20120601
Antidiabetic drug metformin suppresses endotoxin-induced uveitis in rats.	Investigative ophthalmology & visual science 20120601
Effect of different doses of metformin on serum testosterone and insulin in non-diabetic women with breast cancer: a randomized study.	Clinical breast cancer 20120601
Long-term effects of adding exenatide to a regimen of metformin and/or sulfonylurea in type 2 diabetes: an uncontrolled, open-label trial in Hungary.	Clinical therapeutics 20120601
Altering hirsutism through ovulation induction in women with polycystic ovary syndrome.	Obstetrics and gynecology 20120601
Statin is a reasonable treatment option for patients with Polycystic Ovary Syndrome: a meta-analysis of randomized controlled trials.	Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20120601
Cancer risk associated with use of metformin and sulfonylurea in type 2 diabetes: a meta-analysis.	The oncologist 20120601
Cardiovascular disease and oral agent glucose-lowering therapies in the management of type 2 diabetes.	Diabetes technology & therapeutics 20120601
Glibenclamide-pregnenolone derivative has greater hypoglycemic effects and biodistribution than glibenclamide-OH in alloxan-rats.	Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 20120601
Effect of insulin sensitizer therapy on atherothrombotic and inflammatory profiles associated with insulin resistance.	Mayo Clinic proceedings 20120601
Does metformin increase paraoxonase activity in patients with the metabolic syndrome? Additional data from the MEFISTO study.	Clinical and translational science 20120601
Metformin elicits anticancer effects through the sequential modulation of DICER and c-MYC.	Nature communications 20120529
Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility.	The Cochrane database of systematic reviews 20120516
[Prevention of type 2 diabetes mellitus].	MMW Fortschritte der Medizin 20120516
Metformin and pancreatic cancer: a clue requiring investigation.	Clinical cancer research : an official journal of the American Association for Cancer Research 20120515
Metformin use is associated with better survival of diabetic patients with pancreatic cancer.	Clinical cancer research : an official journal of the American Association for Cancer Research 20120515
Evaluation of guidelines on diabetes medication.	Annals of internal medicine 20120515
Evaluation of guidelines on diabetes medication.	Annals of internal medicine 20120515
Discrepancies among consensus documents, guidelines, clinical practice and the legal framework for the treatment of type 2 diabetes mellitus patients.	Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20120514
Inhibition of hepatic uptake transporters by flavonoids.	European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120512
Metformin-induced AMP-activated protein kinase activation regulates phenylephrine-mediated contraction of rat aorta.	Biochemical and biophysical research communications 20120511
Investigation of an active film coating to prepare new fixed-dose combination tablets for treatment of diabetes.	International journal of pharmaceutics 20120510
[Relationship between the degree of glycemic control and diabetes characteristics and hyperglycemia treatment in type 2 diabetes. DIABES Study].	Medicina clinica 20120505
Effects of metformin on oxidative stress, adenine nucleotides balance, and glucose-induced insulin release impaired by chronic free fatty acids exposure in rat pancreatic islets.	Journal of endocrinological investigation 20120501
A prospective, randomized pilot study evaluating the effects of metformin and lifestyle intervention on patients with prostate cancer receiving androgen deprivation therapy.	BJU international 20120501
Lifestyle intervention improves fitness independent of metformin in obese adolescents.	Medicine and science in sports and exercise 20120501
Initial therapy with the fixed-dose combination of sitagliptin and metformin results in greater improvement in glycaemic control compared with pioglitazone monotherapy in patients with type 2 diabetes.	Diabetes, obesity & metabolism 20120501
Metformin alters the expression profiles of microRNAs in human pancreatic cancer cells.	Diabetes research and clinical practice 20120501
Metformin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and modulation of the mTOR pathway.	Gynecologic oncology 20120501
Chronic GLP-1 receptor activation by exendin-4 induces expansion of pancreatic duct glands in rats and accelerates formation of dysplastic lesions and chronic pancreatitis in the Kras(G12D) mouse model.	Diabetes 20120501
MicroRNA-21-mediated regulation of Sprouty2 protein expression enhances the cytotoxic effect of 5-fluorouracil and metformin in colon cancer cells.	International journal of molecular medicine 20120501
Biowaiver approach for biopharmaceutics classification system class 3 compound metformin hydrochloride using in silico modeling.	Journal of pharmaceutical sciences 20120501
Metformin ameliorates IL-6-induced hepatic insulin resistance via induction of orphan nuclear receptor small heterodimer partner (SHP) in mouse models.	Diabetologia 20120501
Metformin-associated lactic acidosis masquerading as ischemic bowel.	The American journal of medicine 20120501
Pro12Ala polymorphism of the PPAR-γ2 gene, metabolic syndrome and response to metformin in clozapine-treated patients.	Schizophrenia research 20120501
Dapagliflozin, metformin XR, or both: initial pharmacotherapy for type 2 diabetes, a randomised controlled trial.	International journal of clinical practice 20120501
Pharmacokinetic and pharmacodynamic interaction between nifedipine and metformin in rats: competitive inhibition for metabolism of nifedipine and metformin by each other via CYP isozymes.	Xenobiotica; the fate of foreign compounds in biological systems 20120501
Metformin improves pregnancy and live-birth rates in women with polycystic ovary syndrome (PCOS): a multicenter, double-blind, placebo-controlled randomized trial.	The Journal of clinical endocrinology and metabolism 20120501
Efficacy and tolerability of the DPP-4 inhibitor alogliptin combined with pioglitazone, in metformin-treated patients with type 2 diabetes.	The Journal of clinical endocrinology and metabolism 20120501
Initiation of sulfonylureas versus metformin is associated with higher blood pressure at one year.	Pharmacoepidemiology and drug safety 20120501
Glycemic control over 5 years in 4,900 people with type 2 diabetes: real-world diabetes therapy in a clinical trial cohort.	Diabetes care 20120501
Soluble platelet/endothelial cell adhesion molecule (sPECAM)-1 is increased in polycystic ovary syndrome and related to endothelial dysfunction.	Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20120501
Statin use as a moderator of metformin effect on risk for prostate cancer among type 2 diabetic patients.	Diabetes care 20120501
Metformin, other antidiabetic drugs, and risk of Alzheimer's disease: a population-based case-control study.	Journal of the American Geriatrics Society 20120501
Worry vs. knowledge about treatment-associated hypoglycaemia and weight gain in type 2 diabetic patients on metformin and/or sulphonylurea.	Current medical research and opinion 20120501
A systematic review and meta-analysis of randomized controlled trials comparing pioglitazone versus metformin in the treatment of polycystic ovary syndrome.	Current medical research and opinion 20120501
High-performance liquid chromatography quadrupole time-of-flight mass spectrometry method for the analysis of antidiabetic drugs in aqueous environmental samples.	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120501
Therapeutic effects of calcium & vitamin D supplementation in women with PCOS.	Complementary therapies in clinical practice 20120501
Endometrial shedding effect on conception and live birth in women with polycystic ovary syndrome.	Obstetrics and gynecology 20120501
Reweighted Mahalanobis distance matching for cluster-randomized trials with missing data.	Pharmacoepidemiology and drug safety 20120501
Metformin in obesity, cancer and aging: addressing controversies.	Aging 20120501
Metformin and the mTOR inhibitor everolimus (RAD001) sensitize breast cancer cells to the cytotoxic effect of chemotherapeutic drugs in vitro.	Anticancer research 20120501
A retrospective in vitro study of the impact of anti-diabetics and cardioselective pharmaceuticals on breast cancer.	Anticancer research 20120501
[Metformin-associated lactic acidosis: incidence, diagnosis, prognostic factors and treatment].	Revista espanola de anestesiologia y reanimacion 20120501
[Medicines for type 2 diabetes: fine tuning rather than redesign].	Medizinische Monatsschrift fur Pharmazeuten 20120501
[Biguanide].	Nihon rinsho. Japanese journal of clinical medicine 20120501
Association between sitagliptin adherence and self-monitoring of blood glucose.	Journal of diabetes science and technology 20120501
In type 2 diabetes patients, insulin glargine is associated with lower postprandial release of intact proinsulin compared with sulfonylurea treatment.	Journal of diabetes science and technology 20120501
Bioassay-guided antidiabetic study of Phaleria macrocarpa fruit extract.	Molecules (Basel, Switzerland) 20120430
[Vitamin B12 deficiency in diabetic patients taking metformin].	Medicina clinica 20120428
Report was overpositive about their benefits.	BMJ (Clinical research ed.) 20120424
Prescribed with gusto despite 'uncertain' benefits.	BMJ (Clinical research ed.) 20120424
Comparison of metformin and insulin versus insulin alone for type 2 diabetes: systematic review of randomised clinical trials with meta-analyses and trial sequential analyses.	BMJ (Clinical research ed.) 20120419
Survival advantage observed with the use of metformin in patients with type II diabetes and colorectal cancer.	British journal of cancer 20120410
A phase I study of temsirolimus and metformin in advanced solid tumours.	Investigational new drugs 20120401
Initiation of insulin among veterans with type 2 diabetes and sustained elevation of A1c.	Primary care diabetes 20120401
Adherence to hypoglycaemic medication among people with type 2 diabetes in primary care.	Primary care diabetes 20120401
Inhibition of p42 MAPK using a nonviral vector-delivered siRNA potentiates the anti-tumor effect of metformin in prostate cancer cells.	Nanomedicine (London, England) 20120401
Longitudinal change in HbA1c after insulin initiation in primary care patients with type 2 diabetes: a database analysis in UK and Germany.	Primary care diabetes 20120401
Adding saxagliptin to extended-release metformin vs. uptitrating metformin dosage.	Diabetes, obesity & metabolism 20120401
DPP-4 inhibitors in the management of type 2 diabetes: a critical review of head-to-head trials.	Diabetes & metabolism 20120401
Addition of insulin glargine or NPH insulin to metformin monotherapy in poorly controlled type 2 diabetic patients decreases IGF-I bioactivity similarly.	Diabetologia 20120401
Effect of metformin on the proliferation, migration, and MMP-2 and -9 expression of human umbilical vein endothelial cells.	Molecular medicine reports 20120401
Comparative effectiveness of incident oral antidiabetic drugs on kidney function.	Kidney international 20120401
Metformin reduces endogenous reactive oxygen species and associated DNA damage.	Cancer prevention research (Philadelphia, Pa.) 20120401
Distinct effects of pioglitazone and metformin on circulating sclerostin and biochemical markers of bone turnover in men with type 2 diabetes mellitus.	European journal of endocrinology 20120401
Metformin inhibits growth of thyroid carcinoma cells, suppresses self-renewal of derived cancer stem cells, and potentiates the effect of chemotherapeutic agents.	The Journal of clinical endocrinology and metabolism 20120401
Use of antidiabetic agents and the risk of pancreatic cancer: a case-control analysis.	The American journal of gastroenterology 20120401
Effect of saxagliptin as add-on therapy in patients with poorly controlled type 2 diabetes on insulin alone or insulin combined with metformin.	Current medical research and opinion 20120401
Dipeptidyl peptidase-4 inhibitors: 3 years of experience.	Diabetes technology & therapeutics 20120401
Anti-diabetic activities of Acanthopanax senticosus polysaccharide (ASP) in combination with metformin.	International journal of biological macromolecules 20120401
Antidiabetic drug metformin alleviates endotoxin-induced fulminant liver injury in mice.	International immunopharmacology 20120401
Metformin prevents the development of chronic heart failure in the SHHF rat model.	Diabetes 20120401
Metformin reduces vascular production of vasoconstrictor prostanoids in fructose overloaded rats.	Autonomic & autacoid pharmacology 20120401
KCNJ11 gene E23K variant and therapeutic response to sulfonylureas.	European journal of internal medicine 20120401
Reply to: Ahren B et al. Mechanisms of action of the dipeptidyl peptidase-4 inhibitor vildagliptin in humans. Diabetes Obes Metab 2011; 13(9): 775-783 and Ahren B et al. Clinical evidence and mechanistic basis for vildagliptin's action when added to metformin. Diabetes Obes Metab 2011; 13(3): 193-203.	Diabetes, obesity & metabolism 20120401
The design of the liraglutide clinical trial programme.	Diabetes, obesity & metabolism 20120401
Liraglutide: from clinical trials to clinical practice.	Diabetes, obesity & metabolism 20120401
Metformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt/β-catenin signaling.	Cancer prevention research (Philadelphia, Pa.) 20120401
Genetic variants of organic cation transporter 1 (OCT1) and OCT2 significantly reduce lamivudine uptake.	Biopharmaceutics & drug disposition 20120401
Metformin suppresses growth of human head and neck squamous cell carcinoma via global inhibition of protein translation.	Cell cycle (Georgetown, Tex.) 20120401
Steps toward the meaningful translation of prevention strategies for type 2 diabetes.	Diabetes care 20120401
The 10-year cost-effectiveness of lifestyle intervention or metformin for diabetes prevention: an intent-to-treat analysis of the DPP/DPPOS.	Diabetes care 20120401
Long-term safety, tolerability, and weight loss associated with metformin in the Diabetes Prevention Program Outcomes Study.	Diabetes care 20120401
Metformin and hepatic carcinogenesis.	Cancer prevention research (Philadelphia, Pa.) 20120401
Metformin prevents liver tumorigenesis by inhibiting pathways driving hepatic lipogenesis.	Cancer prevention research (Philadelphia, Pa.) 20120401
Metformin prevents the development of oral squamous cell carcinomas from carcinogen-induced premalignant lesions.	Cancer prevention research (Philadelphia, Pa.) 20120401
Prevention of mutagenesis: new potential mechanisms of metformin action in neoplastic cells.	Cancer prevention research (Philadelphia, Pa.) 20120401
Reappraisal of metformin efficacy in the treatment of type 2 diabetes: a meta-analysis of randomised controlled trials.	PLoS medicine 20120401
Recommendations for improving adherence to type 2 diabetes mellitus therapy--focus on optimizing oral and non-insulin therapies.	The American journal of managed care 20120401
The role of the nurse practitioner in the diagnosis and early management of type 2 diabetes.	Journal of the American Academy of Nurse Practitioners 20120401
Therapeutic choices, and the nurse practitioner's role, in type 2 diabetes when metformin alone is no longer enough.	Journal of the American Academy of Nurse Practitioners 20120401
Insulin initiation in type 2 diabetes: what are the treatment regimen options and how can we best help patients feel empowered?	Journal of the American Academy of Nurse Practitioners 20120401
Metformin-induced preferential killing of breast cancer initiating CD44+CD24-/low cells is sufficient to overcome primary resistance to trastuzumab in HER2+ human breast cancer xenografts.	Oncotarget 20120401
Metformin accelerates the growth of BRAF V600E-driven melanoma by upregulating VEGF-A.	Cancer discovery 20120401
Lactic acidosis in a diabetic patient treated with metformin undergoing hepatic resection.	British journal of hospital medicine (London, England : 2005) 20120401
Competitive CE-UV binding tests for selective recognition of bisphenol A by molecularly imprinted polymer particles.	Electrophoresis 20120401
Hepatorenal repercussions of alcoholic exposure in a rat model: a dose-dependent study of metformin intervention.	Iranian biomedical journal 20120401
The role of ATM in response to metformin treatment and activation of AMPK.	Nature genetics 20120328
The role of ATM in response to metformin treatment and activation of AMPK.	Nature genetics 20120328
The role of ATM in response to metformin treatment and activation of AMPK.	Nature genetics 20120328
The effect of metformin on food intake and its potential role in hypothalamic regulation in obese diabetic rats.	Brain research 20120320
Metformin lowers the threshold for stress-induced senescence: a role for the microRNA-200 family and miR-205.	Cell cycle (Georgetown, Tex.) 20120315
Effects of lifestyle modification and metformin on atherosclerotic indices among HIV-infected patients with the metabolic syndrome.	AIDS (London, England) 20120313
Phenformin as prophylaxis and therapy in breast cancer xenografts.	British journal of cancer 20120313
The role of dipeptidyl peptidase-4 inhibitors.	BMJ (Clinical research ed.) 20120312
Dipeptidyl peptidase-4 inhibitors for treatment of type 2 diabetes mellitus in the clinical setting: systematic review and meta-analysis.	BMJ (Clinical research ed.) 20120312
Disposition of metformin: variability due to polymorphisms of organic cation transporters.	Annals of medicine 20120301
Familial occurrence of neonatal diabetes with duplications in chromosome 6q24: treatment with sulfonylurea and 40-yr follow-up.	Pediatric diabetes 20120301
Effect of metformin on survival outcomes in diabetic patients with triple receptor-negative breast cancer.	Cancer 20120301
Diagnosis and therapy of polycystic ovarian syndrome: results of a survey among German gynecologists with a review on literature.	Archives of gynecology and obstetrics 20120301
Impaired gallbladder motility and the effect of metformin therapy in patients with polycystic ovary syndrome.	Clinical endocrinology 20120301
Cost-utility analysis of liraglutide compared with sulphonylurea or sitagliptin, all as add-on to metformin monotherapy in Type 2 diabetes mellitus.	Diabetic medicine : a journal of the British Diabetic Association 20120301
Effects of a combination of oral anti-diabetes drugs with basal insulin therapy on β-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes.	Diabetes/metabolism research and reviews 20120301
Discontinuation of statins among patients with type 2 diabetes.	Diabetes/metabolism research and reviews 20120301
Improved gall bladder motility in PCOS women treated with metformin--interaction of free fatty acids with circulating cholecystokinin?	Clinical endocrinology 20120301
Metformin after bariatric surgery--an acid problem.	Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20120301
Efficacy of metformin for prevention of weight gain in psychiatric populations: a review.	International clinical psychopharmacology 20120301
The impact of initiating biphasic human insulin 30 therapy in type 2 diabetes patients after failure of oral antidiabetes drugs.	Diabetes technology & therapeutics 20120301
Optimization of a dual mechanism gastrofloatable and gastroadhesive delivery system for narrow absorption window drugs.	AAPS PharmSciTech 20120301
Reduction of insulin signaling upregulates angiopoietin-like protein 4 through elevated free fatty acids in diabetic mice.	Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20120301
Altered redox homeostasis in human diabetes saliva.	Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20120301
Comparing the effects of insulin glargine and thiazolidinediones on plasma lipids in type 2 diabetes: a patient-level pooled analysis.	Diabetes/metabolism research and reviews 20120301
Metformin inhibits cell proliferation, migration and invasion by attenuating CSC function mediated by deregulating miRNAs in pancreatic cancer cells.	Cancer prevention research (Philadelphia, Pa.) 20120301
Beneficial effects of metformin and irbesartan on advanced glycation end products (AGEs)-RAGE-induced proximal tubular cell injury.	Pharmacological research 20120301
Metformin differentially activates ER stress signaling pathways without inducing apoptosis.	Disease models & mechanisms 20120301
Rosiglitazone and metformin have opposite effects on intestinal absorption of oligopeptides via the proton-dependent PepT1 transporter.	Molecular pharmacology 20120301
Cellular and molecular mechanisms of metformin: an overview.	Clinical science (London, England : 1979) 20120301
Antihyperglycemic and antihyperlipidemic effect of Santalum album in streptozotocin induced diabetic rats.	Pharmaceutical biology 20120301
Interactions between tumor cells and microenvironment in breast cancer: a new opportunity for targeted therapy.	Cancer science 20120301
Fetuin A in nonalcoholic fatty liver disease: in vivo and in vitro studies.	European journal of endocrinology 20120301
Anti-hyperglycemic and anti-hypercholesterolemic effects of Aloe vera leaf gel in hyperlipidemic type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial.	Planta medica 20120301
A humanized anti-IGF-1R monoclonal antibody (R1507) and/or metformin enhance gemcitabine-induced apoptosis in pancreatic cancer cells.	Oncology reports 20120301
Weight loss/maintenance as an effective tool for controlling type 2 diabetes: novel methodology to sustain weight reduction.	Diabetes/metabolism research and reviews 20120301
Insulin glargine and risk of cancer: a cohort study in the French National Healthcare Insurance Database.	Diabetologia 20120301
The antidiabetic drug metformin inhibits gastric cancer cell proliferation in vitro and in vivo.	Molecular cancer therapeutics 20120301
Overfed Ossabaw swine with early stage metabolic syndrome have normal coronary collateral development in response to chronic ischemia.	Basic research in cardiology 20120301
Potential risks of metformin in transplant patients.	American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20120301
Effects of dapagliflozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin.	The Journal of clinical endocrinology and metabolism 20120301
Type 2 diabetes and obesity metabolic interactions: common factors for breast cancer risk and novel approaches to prevention and therapy.	Current diabetes reviews 20120301
Polycystic kidney disease: a 2011 update.	Current opinion in nephrology and hypertension 20120301
Cost effectiveness of saxagliptin and metformin versus sulfonylurea and metformin in the treatment of type 2 diabetes mellitus in Germany: a Cardiff diabetes model analysis.	Clinical drug investigation 20120301
Metformin versus lifestyle changes in treating women with polycystic ovary syndrome.	Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20120301
Saxagliptin plus metformin combination in patients with type 2 diabetes and renal impairment.	Expert opinion on drug metabolism & toxicology 20120301
Activation of AMP-activated protein kinase (AMPK) provides a metabolic barrier to reprogramming somatic cells into stem cells.	Cell cycle (Georgetown, Tex.) 20120301
Metformin rescues cell surface major histocompatibility complex class I (MHC-I) deficiency caused by oncogenic transformation.	Cell cycle (Georgetown, Tex.) 20120301
Patterns of medication initiation in newly diagnosed diabetes mellitus: quality and cost implications.	The American journal of medicine 20120301
Metformin-induced hepatotoxicity.	Diabetes care 20120301
Comment on: Rowan et al. Metformin in Gestational diabetes: The Offspring Follow-Up (MiG TOFU): body composition at 2 years of age. Diabetes Care 2011;34:2279-2284.	Diabetes care 20120301
Comment on: Rowan et al. Metformin in Gestational diabetes: The Offspring Follow-Up (MiG TOFU): body composition at 2 years of age. Diabetes Care 2011;34:2279-2284.	Diabetes care 20120301
Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy.	Cell death & disease 20120301
Low hemoglobin A(1c)--good diabetic control?	Clinical chemistry 20120301
Incretin-based therapies in clinical practice: from efficacy to effectiveness. Focus on liraglutide.	Minerva endocrinologica 20120301
Neuroendocrine and endocrine dysfunction in the hyperinsulinemic PCOS patient: the role of metformin.	Minerva endocrinologica 20120301
Menopausal obesity and metabolic syndrome - PolSenior study.	Minerva endocrinologica 20120301
Metformin and cancer stem cells: old drug, new targets.	Cancer prevention research (Philadelphia, Pa.) 20120301
The work-up for mixed hyperlipidemia: a case study.	The Journal of family practice 20120301
Antidiabetic and antioxidant effect of Semecarpus anacardium Linn. nut milk extract in a high-fat diet STZ-induced type 2 diabetic rat model.	Journal of dietary supplements 20120301
Better care for PCOS. Studying women's genes to find out what works.	Diabetes forecast 20120301
Design and in vitro and in vivo characterization of mucoadhesive matrix pellets of metformin hydrochloride for oral controlled release: a technical note.	Archives of pharmacal research 20120301
[Use of insulin sensitizers in the treatment of infertility in patients with polycystic ovary syndrome (POS)].	Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia 20120301
Prescription patterns for diabetes mellitus and therapeutic implications: a population-based analysis.	Arquivos brasileiros de endocrinologia e metabologia 20120301
Comparing the efficacy and safety profile of sitagliptin versus glimepiride in patients of type 2 diabetes mellitus inadequately controlled with metformin alone.	The Journal of the Association of Physicians of India 20120301
Metformin associated B12 deficiency.	The Journal of the Association of Physicians of India 20120301
Role of angiotensin II-mediated AMPK inactivation on obesity-related salt-sensitive hypertension.	Biochemical and biophysical research communications 20120217
Antidiabetic effect of total saponins from Entada phaseoloides (L.) Merr. in type 2 diabetic rats.	Journal of ethnopharmacology 20120215
Oral pharmacologic treatment of type 2 diabetes mellitus: a clinical practice guideline from the American College of Physicians.	Annals of internal medicine 20120207
Summaries for patients: Oral drug treatment of type 2 diabetes mellitus: a clinical practice guideline from the American College of Physicians.	Annals of internal medicine 20120207
Drug-induced bullous pemphigoid in diabetes mellitus patients receiving dipeptidyl peptidase-IV inhibitors plus metformin.	Journal of the European Academy of Dermatology and Venereology : JEADV 20120201
Linearization of the MS response function: case study for metformin assay in plasma samples for bioequivalence purposes.	Biomedical chromatography : BMC 20120201
Assessment of treatment algorithms including amantadine, metformin, and zonisamide for the prevention of weight gain with olanzapine: a randomized controlled open-label study.	The Journal of clinical psychiatry 20120201
Metformin as a cause of high stomal output.	Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 20120201
Metformin administration in patients with polycystic ovary syndrome who receive gonadotropins for in vitro fertilization cycles: 10-year experience in a large infertile population.	Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20120201
Metformin-induced leukocytoclastic vasculitis: a case report.	American journal of clinical dermatology 20120201
Diabetes mellitus and risk of hepatocellular carcinoma: a systematic review and meta-analysis.	Diabetes/metabolism research and reviews 20120201
ENPP1 mRNA levels in white blood cells and prediction of metformin efficacy in type 2 diabetic patients: a preliminary evidence.	Nutrition, metabolism, and cardiovascular diseases : NMCD 20120201
Targeting AMPK in the treatment of malignancies.	Journal of cellular biochemistry 20120201
Metformin-associated lactic acidosis following acute kidney injury. Efficacious treatment with continuous renal replacement therapy.	Diabetic medicine : a journal of the British Diabetic Association 20120201
Type 2 diabetes, metformin and lactic acidosis-defining the risk and promoting safe practice.	Diabetic medicine : a journal of the British Diabetic Association 20120201
Metformin-treated patients with type 2 diabetes have normal mitochondrial complex I respiration.	Diabetologia 20120201
Telecare Provides comparable efficacy to conventional self-monitored blood glucose in patients with type 2 diabetes titrating one injection of insulin glulisine-the ELEONOR study.	Diabetes technology & therapeutics 20120201
Unlicensed use of metformin in children and adolescents in Germany and France.	British journal of clinical pharmacology 20120201
Gestational diabetes: implications for cardiovascular health.	Current diabetes reports 20120201
Caveolin-1 is essential for metformin inhibitory effect on IGF1 action in non-small-cell lung cancer cells.	FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20120201
Metformin causes nitric oxide-mediated dilatation in a shorter time than insulin in the iliac artery of the anesthetized pig.	Journal of cardiovascular pharmacology 20120201
Competitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney.	The Journal of pharmacology and experimental therapeutics 20120201
Metformin may antagonize Lin28 and/or Lin28B activity, thereby boosting let-7 levels and antagonizing cancer progression.	Medical hypotheses 20120201
Chemoprevention in colorectal cancer--where we stand and what we have learned from twenty year's experience.	The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland 20120201
Introduction of metformin for gestational diabetes mellitus in clinical practice: Has it had an impact?	European journal of obstetrics, gynecology, and reproductive biology 20120201
Management of diabetes in pregnancy.	Current diabetes reports 20120201
Medical therapy for nonalcoholic fatty liver disease in children and adolescents.	Expert review of gastroenterology & hepatology 20120201
Androgens and antimüllerian hormone in mothers with polycystic ovary syndrome and their newborns.	Fertility and sterility 20120201
Large enhancement of skeletal muscle cell glucose uptake and suppression of hepatocyte glucose-6-phosphatase activity by weak uncouplers of oxidative phosphorylation.	Biochimica et biophysica acta 20120201
Use of metformin is not associated with a decreased risk of colorectal cancer: a case-control analysis.	Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20120201
Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program.	Diabetes care 20120201
Association of biochemical B₁₂ deficiency with metformin therapy and vitamin B₁₂ supplements: the National Health and Nutrition Examination Survey, 1999-2006.	Diabetes care 20120201
Acute renal failure after intragastric balloon in morbidly-obese metformin-treated diabetic patients. Report of two cases.	Nutrition, metabolism, and cardiovascular diseases : NMCD 20120201
Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naive patients with type 2 diabetes (DURATION-4): a 26-week double-blind study.	Diabetes care 20120201
Pharmacokinetics of a fixed-dose glimepiride/sustained-release metformin combination.	International journal of clinical pharmacology and therapeutics 20120201
Mortality after incident cancer in people with and without type 2 diabetes: impact of metformin on survival.	Diabetes care 20120201
Rapid recovery from acute kidney injury in a patient with metformin-associated lactic acidosis and hypothermia.	The American journal of medicine 20120201
Metformin: a potential novel endometrial cancer therapy.	International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20120201
Quantifying the effect of metformin treatment and dose on glycemic control.	Diabetes care 20120201
Highlights from the latest articles in diabetes pharmacogenomics.	Pharmacogenomics 20120201
Male partial hypogonadotrophic hypogonadism with gynaecomastia and metabolic syndrome.	Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 20120201
[Diet, metformin and inositol in overweight and obese women with polycystic ovary syndrome: effects on body composition].	Minerva ginecologica 20120201
Fixed-dose glucose-lowering drug combinations: preventable lactic acidosis.	Prescrire international 20120201
Hypoglycemic effect and mechanism of a proteoglycan from ganoderma lucidum on streptozotocin-induced type 2 diabetic rats.	European review for medical and pharmacological sciences 20120201
Does use of metformin protect against cancer in Type 2 diabetes mellitus?	Journal of endocrinological investigation 20120201

Metformin and caffeic acid regulate metabolic reprogramming in human cervical carcinoma SiHa/HTB-35 cells and augment anticancer activity of Cisplatin via cell cycle regulation.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20170801

Multidrug and toxin extrusion proteins mediate cellular transport of cadmium.

Toxicology and applied pharmacology 20170101

Lobeglitazone, a Novel Thiazolidinedione, Improves Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes: Its Efficacy and Predictive Factors Related to Responsiveness.

Journal of Korean medical science 20170101

Editor's Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction.

Toxicological sciences : an official journal of the Society of Toxicology 20161201

Effect of canagliflozin and metformin on cortical neurotransmitters in a diabetic rat model.

Chemico-biological interactions 20161025

Metformin Improves Metabolic Memory in High Fat Diet (HFD)-induced Renal Dysfunction.

The Journal of biological chemistry 20161014

Organic Cation Transporter 2 Overexpression May Confer an Increased Risk of Gentamicin-Induced Nephrotoxicity.

Antimicrobial agents and chemotherapy 20160901

Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin.

Nature genetics 20160901

Sodium butyrate reduces insulin-resistance, fat accumulation and dyslipidemia in type-2 diabetic rat: A comparative study with metformin.

Chemico-biological interactions 20160725

Efficacy, safety, and tolerability of ipragliflozin in Asian patients with type 2 diabetes mellitus and inadequate glycemic control with metformin: Results of a phase 3 randomized, placebo-controlled, double-blind, multicenter trial.

Journal of diabetes investigation 20160501

Metformin administration induces hepatotoxic effects in paraoxonase-1-deficient mice.

Chemico-biological interactions 20160405

Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro.

Toxicology letters 20160105

Metformin prevents cancer metastasis by inhibiting M2-like polarization of tumor associated macrophages.

Oncotarget 20151103

Preventing Allograft Rejection by Targeting Immune Metabolism.

Cell reports 20151027

Effective impairment of myeloma cells and their progenitors by blockade of monocarboxylate transportation.

Oncotarget 20151020

Specificity protein (Sp) transcription factors and metformin regulate expression of the long non-coding RNA HULC.

Oncotarget 20150922

Lobeglitazone and pioglitazone as add-ons to metformin for patients with type 2 diabetes: a 24-week, multicentre, randomized, double-blind, parallel-group, active-controlled, phase III clinical trial with a 28-week extension.

Diabetes, obesity & metabolism 20150601

Metformin inhibits 7,12-dimethylbenz[a]anthracene-induced breast carcinogenesis and adduct formation in human breast cells by inhibiting the cytochrome P4501A1/aryl hydrocarbon receptor signaling pathway.

Toxicology and applied pharmacology 20150415

Orotic acid induces hypertension associated with impaired endothelial nitric oxide synthesis.

Toxicological sciences : an official journal of the Society of Toxicology 20150401

Metformin aggravates immune-mediated liver injury in mice.

Archives of toxicology 20150301

Metformin Attenuates Testosterone-Induced Prostatic Hyperplasia in Rats: A Pharmacological Perspective.

Scientific reports 20150101

Pharmacological activation of AMPK ameliorates perivascular adipose/endothelial dysfunction in a manner interdependent on AMPK and SIRT1.

Pharmacological research 20141101

Metformin suppresses CYP1A1 and CYP1B1 expression in breast cancer cells by down-regulating aryl hydrocarbon receptor expression.

Toxicology and applied pharmacology 20141001

Chronic treatment with metformin suppresses toll-like receptor 4 signaling and attenuates left ventricular dysfunction following myocardial infarction.

European journal of pharmacology 20140815

Metformin inhibits hepatitis B virus protein production and replication in human hepatoma cells.

Journal of viral hepatitis 20140801

A phase II, randomized, placebo-controlled, double-blind, multi-dose study of SRT2104, a SIRT1 activator, in subjects with type 2 diabetes.

British journal of clinical pharmacology 20140701

Metformin protects against seizures, learning and memory impairments and oxidative damage induced by pentylenetetrazole-induced kindling in mice.

Biochemical and biophysical research communications 20140613

Involvement of catalase in the protective benefits of metformin in mice with oxidative liver injury.

Chemico-biological interactions 20140605

Empagliflozin as add-on to metformin in patients with type 2 diabetes: a 24-week, randomized, double-blind, placebo-controlled trial.

Diabetes care 20140601

Metformin induces PGC-1α expression and selectively affects hepatic PGC-1α functions.

British journal of pharmacology 20140501

Ondansetron can enhance cisplatin-induced nephrotoxicity via inhibition of multiple toxin and extrusion proteins (MATEs).

Toxicology and applied pharmacology 20131115

Metformin inhibits heme oxygenase-1 expression in cancer cells through inactivation of Raf-ERK-Nrf2 signaling and AMPK-independent pathways.

Toxicology and applied pharmacology 20130901

Transfer of metformin across the rat placenta is mediated by organic cation transporter 3 (OCT3/SLC22A3) and multidrug and toxin extrusion 1 (MATE1/SLC47A1) protein.

Reproductive toxicology (Elmsford, N.Y.) 20130801

Visfatin is expressed in human granulosa cells: regulation by metformin through AMPK/SIRT1 pathways and its role in steroidogenesis.

Molecular human reproduction 20130501

Prenatal metformin exposure in mice programs the metabolic phenotype of the offspring during a high fat diet at adulthood.

PloS one 20130101

Miniaturized ionophore-based potentiometric sensors for the flow-injection determination of metformin in pharmaceutical formulations and biological fluids.

The Analyst 20121207

Metformin use is associated with a decreased incidence of colorectal adenomas in diabetic patients with previous colorectal cancer.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20121201

Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling.

Aging 20121201

Type of preadmission antidiabetic treatment and outcome among patients with ischemic stroke: a nationwide follow-up study.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 20121101

Population PK/PD analysis of metformin using the signal transduction model.

British journal of clinical pharmacology 20121101

Differential effects of 3 classes of antidiabetic drugs on olanzapine-induced glucose dysregulation and insulin resistance in female rats.

Journal of psychiatry & neuroscience : JPN 20121101

Time to failure of oral therapy in children with type 2 diabetes: a single center retrospective chart review.

Pediatric diabetes 20121101

Dapagliflozin has no effect on markers of bone formation and resorption or bone mineral density in patients with inadequately controlled type 2 diabetes mellitus on metformin.

Diabetes, obesity & metabolism 20121101

Metformin pathways: pharmacokinetics and pharmacodynamics.

Pharmacogenetics and genomics 20121101

The effect of metformin on insulin resistance and exercise parameters in patients with heart failure.

European journal of heart failure 20121101

Metformin exposure affects human and mouse fetal testicular cells.

Human reproduction (Oxford, England) 20121101

Patient education on the benefit and risks of medications goes beyond metformin.

Diabetic medicine : a journal of the British Diabetic Association 20121101

Binding studies of the antidiabetic drug, metformin to calf thymus DNA using multispectroscopic methods.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20121101

Metformin targets ovarian cancer stem cells in vitro and in vivo.

Gynecologic oncology 20121101

A high-fat-diet-induced cognitive deficit in rats that is not prevented by improving insulin sensitivity with metformin.

Diabetologia 20121101

Health-related quality of life in women with newly diagnosed polycystic ovary syndrome randomized between clomifene citrate plus metformin or clomifene citrate plus placebo.

Human reproduction (Oxford, England) 20121101

Growth, body composition and metabolic profile of 8-year-old children exposed to metformin in utero.

Scandinavian journal of clinical and laboratory investigation 20121101

Metformin does not alter the risk of lung cancer: a case-control analysis.

Lung cancer (Amsterdam, Netherlands) 20121101

Metformin affects the circadian clock and metabolic rhythms in a tissue-specific manner.

Biochimica et biophysica acta 20121101

Associations of type 2 diabetes and diabetes treatment with breast cancer risk and mortality: a population-based cohort study among British women.

Cancer causes & control : CCC 20121101

Effects of metformin on insulin resistance in heart failure. Which came first: the chicken or the egg?

European journal of heart failure 20121101

Metformin's effect on first-year weight gain: a follow-up study.

Pediatrics 20121101

Fitness, fatness, and metformin.

Medicine and science in sports and exercise 20121101

Orphan nuclear receptor small heterodimer partner negatively regulates growth hormone-mediated induction of hepatic gluconeogenesis through inhibition of signal transducer and activator of transcription 5 (STAT5) transactivation.

The Journal of biological chemistry 20121026

AMP-activated protein kinase: a target for drugs both ancient and modern.

Chemistry & biology 20121026

Central anti-diabetic action of biguanide and thizolidinediones in D-glucose fed and streptozotocin-treated mouse models.

Neuroscience letters 20121018

Long versus short course treatment with metformin and clomiphene citrate for ovulation induction in women with PCOS.

The Cochrane database of systematic reviews 20121017

Removal of charged micropollutants from water by ion-exchange polymers -- effects of competing electrolytes.

Water research 20121015

Molecular mechanisms of lipoapoptosis and metformin protection in GLP-1 secreting cells.

Biochemical and biophysical research communications 20121012

AMP-activated protein kinase stimulates myostatin expression in C2C12 cells.

Biochemical and biophysical research communications 20121012

Effects of metformin on learning and memory behaviors and brain mitochondrial functions in high fat diet induced insulin resistant rats.

Life sciences 20121005

TAp63 is a master transcriptional regulator of lipid and glucose metabolism.

Cell metabolism 20121003

Determination of metformin in rat plasma by HILIC-MS/MS combined with Tecan automation and direct injection.

Biomedical chromatography : BMC 20121001

[Metformin associates lactic acidosis].

Presse medicale (Paris, France : 1983) 20121001

Strict glycaemic control improves skin microcirculation in patients with type 2 diabetes: a report from the Diabetes mellitus And Diastolic Dysfunction (DADD) study.

Diabetes & vascular disease research 20121001

Fatty acids revert the inhibition of respiration caused by the antidiabetic drug metformin to facilitate their mitochondrial β-oxidation.

Biochimica et biophysica acta 20121001

Effect of metformin and spironolactone therapy on OGTT in patients with polycystic ovarian syndrome - a retrospective analysis.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20121001

A primary care register for impaired glucose handling (IGH): impact on cardiometabolic profile.

Primary care diabetes 20121001

Metformin therapy in patients with chronic kidney disease.

Diabetes, obesity & metabolism 20121001

Efficacy and safety of alogliptin added to metformin in Japanese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial with an open-label, long-term extension study.

Diabetes, obesity & metabolism 20121001

A randomized controlled trial of an intensive insulin regimen in patients with hyperglycemic acute lymphoblastic leukemia.

Clinical lymphoma, myeloma & leukemia 20121001

Effects of a combination of sitagliptin plus metformin vs metformin monotherapy on glycemic control, β-cell function and insulin resistance in type 2 diabetic patients.

Diabetes research and clinical practice 20121001

Reduction of oxidative stress and inflammation by blunting daily acute glucose fluctuations in patients with type 2 diabetes: role of dipeptidyl peptidase-IV inhibition.

Diabetes care 20121001

Metformin inhibits growth hormone-mediated hepatic PDK4 gene expression through induction of orphan nuclear receptor small heterodimer partner.

Diabetes 20121001

Metformin impairs the growth of liver kinase B1-intact cervical cancer cells.

Gynecologic oncology 20121001

Occurrence and fate of the antidiabetic drug metformin and its metabolite guanylurea in the environment and during drinking water treatment.

Water research 20121001

Add-on therapies to metformin in type 2 diabetes: what modulates the respective decrements in postprandial and basal glucose?

Diabetes technology & therapeutics 20121001

Is there a dose-response relationship of metformin treatment in patients with polycystic ovary syndrome? Results from a multicentric study.

Human reproduction (Oxford, England) 20121001

Ethinyl estradiol-cyproterone acetate versus low-dose pioglitazone-flutamide-metformin for adolescent girls with androgen excess: divergent effects on CD163, TWEAK receptor, ANGPTL4, and LEPTIN expression in subcutaneous adipose tissue.

The Journal of clinical endocrinology and metabolism 20121001

Effect of insulin versus triple oral therapy on the progression of hepatic steatosis in type 2 diabetes.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20121001

Different antidiabetic regimens and the development of renal dysfunction in US Veterans with type 2 diabetes mellitus.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20121001

Continuous glucose profiles with vildagliptin versus sitagliptin in add-on to metformin: results from the randomized Optima study.

Diabetes & metabolism 20121001

Enhanced cytotoxic effect of low doses of metformin combined with ionizing radiation on hepatoma cells via ATP deprivation and inhibition of DNA repair.

Oncology reports 20121001

Diabetes and pancreatic cancer.

Endocrine-related cancer 20121001

Metformin and breast cancer risk: a meta-analysis and critical literature review.

Breast cancer research and treatment 20121001

Cancer outcomes and all-cause mortality in adults allocated to metformin: systematic review and collaborative meta-analysis of randomised clinical trials.

Diabetologia 20121001

Diabetes: Add-on to metformin in T2DM--linagliptin or glimepiride?

Nature reviews. Endocrinology 20121001

Metformin in early breast cancer: a prospective window of opportunity neoadjuvant study.

Breast cancer research and treatment 20121001

Rejuvenating regeneration: metformin activates endogenous adult stem cells.

Cell cycle (Georgetown, Tex.) 20121001

Status of clomiphene citrate and metformin for infertility in PCOS.

Trends in endocrinology and metabolism: TEM 20121001

Metformin for schizophrenia: an editorial comment to Curtis J, Newall H, Shiers D, Samaras K. 'Considering metformin in cardiometabolic protection in psychosis'.

Acta psychiatrica Scandinavica 20121001

Patterns of medication initiation in newly diagnosed diabetes mellitus: quality and cost implications.

The American journal of medicine 20121001

Insulin sensitization therapy and the heart: focus on metformin and thiazolidinediones.

Heart failure clinics 20121001

Cost-utility analysis of liraglutide versus glimepiride as add-on to metformin in type 2 diabetes patients in China.

International journal of technology assessment in health care 20121001

Effects of saxagliptin added to sub-maximal doses of metformin compared with uptitration of metformin in type 2 diabetes: the PROMPT study.

Current medical research and opinion 20121001

Safety of exenatide once weekly in patients with type 2 diabetes mellitus treated with a thiazolidinedione alone or in combination with metformin for 2 years.

Clinical therapeutics 20121001

Chemerin and apelin are positively correlated with inflammation in obese type 2 diabetic patients.

Chinese medical journal 20121001

[Continuous glucose monitoring in glimipiride plus metformin treated type 2 diabetic patients during the month of Ramadan].

La Tunisie medicale 20121001

[Proposal for the modification of metformin use in patients with chronic kidney disease].

Orvosi hetilap 20120930

What's preventing us from preventing type 2 diabetes?

The New England journal of medicine 20120927

Cerulein hyperstimulation decreases AMP-activated protein kinase levels at the site of maximal zymogen activation.

American journal of physiology. Gastrointestinal and liver physiology 20120915

Glycemic control in youth with type 2 diabetes.

The New England journal of medicine 20120913

Linagliptin: a review of its use in the management of type 2 diabetes mellitus.

Drugs 20120910

Metformin inhibits inflammatory response via AMPK-PTEN pathway in vascular smooth muscle cells.

Biochemical and biophysical research communications 20120907

Addition of liraglutide in patients with Type 2 diabetes well controlled on metformin monotherapy improves several markers of vascular function.

Diabetic medicine : a journal of the British Diabetic Association 20120901

Metformin decreases plasma resistin concentrations in pediatric patients with impaired glucose tolerance: a placebo-controlled randomized clinical trial.

Metabolism: clinical and experimental 20120901

Increase in overall mortality risk in patients with type 2 diabetes receiving glipizide, glyburide or glimepiride monotherapy versus metformin: a retrospective analysis.

Diabetes, obesity & metabolism 20120901

Effect of antidiabetic agents added to metformin on glycaemic control, hypoglycaemia and weight change in patients with type 2 diabetes: a network meta-analysis.

Diabetes, obesity & metabolism 20120901

Imeglimin, a novel glimin oral antidiabetic, exhibits a good efficacy and safety profile in type 2 diabetic patients.

Diabetes, obesity & metabolism 20120901

Metformin preconditioning protects Daphnia pulex from lethal hypoxic insult involving AMPK, HIF and mTOR signaling.

Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20120901

Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats.

Pharmacological research 20120901

Metformin interacts with AMPK through binding to γ subunit.

Molecular and cellular biochemistry 20120901

Inhibition of complex I regulates the mitochondrial permeability transition through a phosphate-sensitive inhibitory site masked by cyclophilin D.

Biochimica et biophysica acta 20120901

The addition of sitagliptin to ongoing metformin therapy significantly improves glycemic control in Chinese patients with type 2 diabetes.

Journal of diabetes 20120901

Interaction of the cardiovascular risk marker asymmetric dimethylarginine (ADMA) with the human cationic amino acid transporter 1 (CAT1).

Journal of molecular and cellular cardiology 20120901

Metformin reverses hexokinase and phosphofructokinase downregulation and intracellular distribution in the heart of diabetic mice.

IUBMB life 20120901

Effects of frequency of follow-up on quality of life of type 2 diabetes patients on oral hypoglycemics.

Diabetes technology & therapeutics 20120901

Association of genetic variation in the organic cation transporters OCT1, OCT2 and multidrug and toxin extrusion 1 transporter protein genes with the gastrointestinal side effects and lower BMI in metformin-treated type 2 diabetes patients.

Pharmacogenetics and genomics 20120901

The C allele of ATM rs11212617 does not associate with metformin response in the Diabetes Prevention Program.

Diabetes care 20120901

Metformin inhibits the development and metastasis of ovarian cancer.

Oncology reports 20120901

Recommendations for diagnosis and management of metformin-induced vitamin B12 (Cbl) deficiency.

Diabetes research and clinical practice 20120901

Diabetes, metformin use, and colon cancer: a population-based cohort study in Taiwan.

European journal of endocrinology 20120901

Metformin inhibits human androgen production by regulating steroidogenic enzymes HSD3B2 and CYP17A1 and complex I activity of the respiratory chain.

Endocrinology 20120901

Abnormal glucose metabolism: diagnosis and management in the ambulatory setting.

Clinical obstetrics and gynecology 20120901

Viewpoint: Central adjudication of myocardial infarction in outcome-driven clinical trials--common patterns in TRITON, RECORD, and PLATO?

Thrombosis and haemostasis 20120901

Targeting the consequences of the metabolic syndrome in the Diabetes Prevention Program.

Arteriosclerosis, thrombosis, and vascular biology 20120901

Investigating metformin for cancer prevention and treatment: the end of the beginning.

Cancer discovery 20120901

AMP-activated protein kinase acts as a negative regulator of high glucose-induced RANKL expression in human periodontal ligament cells.

Chinese medical journal 20120901

Comparative efficacy of thiazolidinediones and metformin for polycystic ovary syndrome.

Saudi medical journal 20120901

A report of the James Watson lecture at Yale University.

The Yale journal of biology and medicine 20120901

Early, aggressive treatment is effective in treating diabetes. Risk of long-term complications reduced significantly.

DukeMedicine healthnews 20120901

Momordica charantia for type 2 diabetes mellitus.

The Cochrane database of systematic reviews 20120815

Diabetes, metformin, and breast cancer in postmenopausal women.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120810

Diabetes, metformin, and breast cancer: lilac time?

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120810

Gliptin versus a sulphonylurea as add-on to metformin.

Lancet (London, England) 20120804

2-year efficacy and safety of linagliptin compared with glimepiride in patients with type 2 diabetes inadequately controlled on metformin: a randomised, double-blind, non-inferiority trial.

Lancet (London, England) 20120804

The effects of metformin on the survival of colorectal cancer patients with diabetes mellitus.

International journal of cancer 20120801

Factors predicting therapeutic efficacy of combination treatment with sitagliptin and metformin in type 2 diabetic patients: the COSMETIC study.

Clinical endocrinology 20120801

Evaluation of dibutyrylchitin as new excipient for sustained drug release.

Drug development and industrial pharmacy 20120801

A case of hypoglycemic hemiparesis and literature review.

Upsala journal of medical sciences 20120801

The risk of overall mortality in patients with Type 2 diabetes receiving different combinations of sulfonylureas and metformin: a retrospective analysis.

Diabetic medicine : a journal of the British Diabetic Association 20120801

Determinants of glycemic control in youth with type 2 diabetes at randomization in the TODAY study.

Pediatric diabetes 20120801

The effect of linagliptin on glycaemic control and tolerability in patients with type 2 diabetes mellitus: a systematic review and meta-analysis.

Diabetes, obesity & metabolism 20120801

Glucose-lowering treatment and clinical results in 163 121 patients with type 2 diabetes: an observational study from the Swedish national diabetes register.

Diabetes, obesity & metabolism 20120801

Metformin monotherapy in youth with recent onset type 2 diabetes: experience from the prerandomization run-in phase of the TODAY study.

Pediatric diabetes 20120801

Efficacy and tolerability of vildagliptin as add-on therapy to metformin in Chinese patients with type 2 diabetes mellitus.

Diabetes, obesity & metabolism 20120801

Relation between diabetes, metformin treatment and the occurrence of malignancies in a Belgian primary care setting.

Diabetes research and clinical practice 20120801

The influence of antidiabetic medications on the development and progression of prostate cancer.

Cancer epidemiology 20120801

Downregulation of chemerin and alleviation of endoplasmic reticulum stress by metformin in adipose tissue of rats.

Diabetes research and clinical practice 20120801

Effect of lifestyle modification and metformin therapy on emerging cardiovascular risk factors in overweight Indian women with polycystic ovary syndrome.

Metabolic syndrome and related disorders 20120801

Effects of chronic treatment with metformin on dipeptidyl peptidase-4 activity, glucagon-like peptide 1 and ghrelin in obese patients with Type 2 diabetes mellitus.

Diabetic medicine : a journal of the British Diabetic Association 20120801

Links among type 2 diabetes, cancer and metformin use: what have we learned?

Diabetes research and clinical practice 20120801

Metformin sensitizes endometrial cancer cells to chemotherapy by repressing glyoxalase I expression.

The journal of obstetrics and gynaecology research 20120801

A potential mechanism of metformin-mediated regulation of glucose homeostasis: inhibition of Thioredoxin-interacting protein (Txnip) gene expression.

Cellular signalling 20120801

Cancer risk in type 2 diabetes.

Current diabetes reports 20120801

Effects of metformin on the expression of GLUT4 in endometrium of obese women with polycystic ovary syndrome.

Biology of reproduction 20120801

Methazolamide is a new hepatic insulin sensitizer that lowers blood glucose in vivo.

Diabetes 20120801

Cardioprotective effects of metformin and vildagliptin in adult rats with insulin resistance induced by a high-fat diet.

Endocrinology 20120801

The treatment of infertility in polycystic ovary syndrome: a brief update.

The Australian & New Zealand journal of obstetrics & gynaecology 20120801

Thyreotropin levels in diabetic patients on metformin treatment.

European journal of endocrinology 20120801

In vitro and in vivo evaluation of a sulfenamide prodrug of basic metformin.

Journal of pharmaceutical sciences 20120801

Comparison of a soluble co-formulation of insulin degludec/insulin aspart vs biphasic insulin aspart 30 in type 2 diabetes: a randomised trial.

European journal of endocrinology 20120801

Inhibition of TNF-α improves the bladder dysfunction that is associated with type 2 diabetes.

Diabetes 20120801

Lower risk of hypoglycemia with sitagliptin compared to glipizide when either is added to metformin therapy: a pre-specified analysis adjusting for the most recently measured HbA(1c) value.

Current medical research and opinion 20120801

Metformin for treatment of antipsychotic-induced amenorrhea and weight gain in women with first-episode schizophrenia: a double-blind, randomized, placebo-controlled study.

The American journal of psychiatry 20120801

Insulin resistance in type 2 diabetic youth.

Current opinion in endocrinology, diabetes, and obesity 20120801

A single-dose, crossover study comparing the pharmacokinetics and pharmacodynamics of 2 formulations of metformin in healthy volunteers.

International journal of clinical pharmacology and therapeutics 20120801

Overview of metformin: special focus on metformin extended release.

Expert opinion on pharmacotherapy 20120801

Combination treatment with ipragliflozin and metformin: a randomized, double-blind, placebo-controlled study in patients with type 2 diabetes mellitus.

Clinical therapeutics 20120801

Metformin is synthetically lethal with glucose withdrawal in cancer cells.

Cell cycle (Georgetown, Tex.) 20120801

Metformin is synthetically lethal with glucose withdrawal in cancer cells.

Cell cycle (Georgetown, Tex.) 20120801

Pregestational diabetes with extreme insulin resistance: use of U-500 insulin in pregnancy.

Obstetrics and gynecology 20120801

Severe hyperandrogenemia and insulin resistance in a 12-year-old girl.

Journal of pediatric and adolescent gynecology 20120801

Metformin as a treatment for antipsychotic drug side effects: special focus on women with schizophrenia.

The American journal of psychiatry 20120801

HbA1C - overall glycemia marker and hemolytic anemia indicator.

Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina 20120801

Efficacy and tolerability of exenatide monotherapy in obese patients with newly diagnosed type 2 diabetes: a randomized, 26 weeks metformin-controlled, parallel-group study.

Chinese medical journal 20120801

Genetic modulation of lipid profiles following lifestyle modification or metformin treatment: the Diabetes Prevention Program.

PLoS genetics 20120801

What comes after metformin for type 2 diabetes.

The Medical letter on drugs and therapeutics 20120723

Dual effect of metformin on breast cancer proliferation in a randomized presurgical trial.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120720

Metformin: a diabetes drug for cancer, or a cancer drug for diabetics?

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120720

Cracking open window of opportunity trials.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120720

Antidiabetic II drug metformin in plants: uptake and translocation to edible parts of cereals, oily seeds, beans, tomato, squash, carrots, and potatoes.

Journal of agricultural and food chemistry 20120718

Illuminating the diabetes-cancer link.

Journal of the National Cancer Institute 20120718

Decoupling the role of image size and calorie intake on gastric retention of swelling-based gastric retentive formulations: pre-screening in the dog model.

International journal of pharmaceutics 20120715

Cardiopulmonary and endothelial effects of metformin treatment in an insulin resistant population.

International journal of cardiology 20120712

Risk identification and interventions to prevent type 2 diabetes in adults at high risk: summary of NICE guidance.

BMJ (Clinical research ed.) 20120712

An old drug for new ideas: metformin promotes adult neurogenesis and spatial memory formation.

Cell stem cell 20120706

Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation.

Cell stem cell 20120706

Untuning the tumor metabolic machine: Targeting cancer metabolism: a bedside lesson.

Nature medicine 20120706

Oral pharmacologic treatment of type 2 diabetes mellitus.

Annals of internal medicine 20120703

Oral pharmacologic treatment of type 2 diabetes mellitus.

Annals of internal medicine 20120703

Oral pharmacologic treatment of type 2 diabetes mellitus.

Annals of internal medicine 20120703

The burden of hospitalization related to diabetes mellitus: a population-based study.

Nutrition, metabolism, and cardiovascular diseases : NMCD 20120701

Cost-effectiveness of saxagliptin (Onglyza®) in type 2 diabetes in Sweden.

Primary care diabetes 20120701

Metformin and thiazolidinediones are associated with improved breast cancer-specific survival of diabetic women with HER2+ breast cancer.

Annals of oncology : official journal of the European Society for Medical Oncology 20120701

Cost and clinical implications of diabetes prevention in an Australian setting: a long-term modeling analysis.

Primary care diabetes 20120701

Sitagliptin promotes macrophage-to-faeces reverse cholesterol transport through reduced intestinal cholesterol absorption in obese insulin resistant CETP-apoB100 transgenic mice.

Diabetes, obesity & metabolism 20120701

A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells.

American journal of physiology. Cell physiology 20120701

Fasting plasma glucose 6-12 weeks after starting insulin glargine predicts likelihood of treatment success: a pooled analysis.

Diabetic medicine : a journal of the British Diabetic Association 20120701

Metformin, metabolic stress, and mitochondria. Focus on 'A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells'.

American journal of physiology. Cell physiology 20120701

A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts.

Diabetologia 20120701

Metformin-inclusive sulfonylurea therapy reduces the risk of Parkinson's disease occurring with Type 2 diabetes in a Taiwanese population cohort.

Parkinsonism & related disorders 20120701

Use of thiazolidinedione and cancer risk in Type 2 diabetes: the Hong Kong diabetes registry.

Diabetes research and clinical practice 20120701

The effect of sitagliptin versus glibenclamide on arterial stiffness, blood pressure, lipids, and inflammation in type 2 diabetes mellitus patients.

Diabetes technology & therapeutics 20120701

Metformin for liver cancer prevention in patients with type 2 diabetes: a systematic review and meta-analysis.

The Journal of clinical endocrinology and metabolism 20120701

Metformin-based treatment for obesity-related hypertension: a randomized, double-blind, placebo-controlled trial.

Journal of hypertension 20120701

Metformin protects against the development of fructose-induced steatosis in mice: role of the intestinal barrier function.

Laboratory investigation; a journal of technical methods and pathology 20120701

Diabetes and cancer II: role of diabetes medications and influence of shared risk factors.

Cancer causes & control : CCC 20120701

Efficacy and safety of taspoglutide in patients with type 2 diabetes inadequately controlled with metformin plus pioglitazone over 24 weeks: T-Emerge 3 trial.

The Journal of clinical endocrinology and metabolism 20120701

Effect of canagliflozin, a sodium glucose co-transporter 2 (SGLT2) inhibitor, on bacteriuria and urinary tract infection in subjects with type 2 diabetes enrolled in a 12-week, phase 2 study.

Current medical research and opinion 20120701

Antiproliferative action of metformin in human lung cancer cell lines.

Oncology reports 20120701

Sequential intensification of metformin treatment in type 2 diabetes with liraglutide followed by randomized addition of basal insulin prompted by A1C targets.

Diabetes care 20120701

Identification of anti-melanogenic natural compounds from Galega officinalis and further drug repositioning.

Journal of dermatological science 20120701

Metformin: direct inhibition of rat ovarian theca-interstitial cell proliferation.

Fertility and sterility 20120701

Drug-induced hypoglycaemia in type 2 diabetes.

Expert opinion on drug safety 20120701

Assessment of the pharmacokinetics of co-administered metformin and lobeglitazone, a thiazolidinedione antihyperglycemic agent, in healthy subjects.

Current medical research and opinion 20120701

Protective effect of metformin on periapical lesions in rats by decreasing the ratio of receptor activator of nuclear factor kappa B ligand/osteoprotegerin.

Journal of endodontics 20120701

β-cell function preservation after 3.5 years of intensive diabetes therapy.

Diabetes care 20120701

Liver fat is reduced by an isoenergetic MUFA diet in a controlled randomized study in type 2 diabetic patients.

Diabetes care 20120701

Metabolomic fingerprint reveals that metformin impairs one-carbon metabolism in a manner similar to the antifolate class of chemotherapy drugs.

Aging 20120701

Metformin, but not glimepiride, improves carotid artery diameter and blood flow in patients with type 2 diabetes mellitus.

Clinics (Sao Paulo, Brazil) 20120701

Initial combination therapy with metformin plus colesevelam in drug-naïve Hispanic patients with early type 2 diabetes.

Postgraduate medicine 20120701

The link between polycystic ovarian syndrome and type 2 diabetes: preventive and therapeutic approach in Israel.

The Israel Medical Association journal : IMAJ 20120701

[Basal insulin and GLP-1 agonist potentiate each other (interview by Dr. med Dirk Einecke)].

MMW Fortschritte der Medizin 20120628

Diabetes: insulin plus metformin for T2DM--are there benefits?

Nature reviews. Endocrinology 20120626

[AMPK: a novel target controlling inflammation].

Sheng li xue bao : [Acta physiologica Sinica] 20120625

Insulin glargine versus sitagliptin in insulin-naive patients with type 2 diabetes mellitus uncontrolled on metformin (EASIE): a multicentre, randomised open-label trial.

Lancet (London, England) 20120616

Choosing a blood-glucose-lowering agent after metformin.

Lancet (London, England) 20120616

Exenatide twice daily versus glimepiride for prevention of glycaemic deterioration in patients with type 2 diabetes with metformin failure (EUREXA): an open-label, randomised controlled trial.

Lancet (London, England) 20120616

Differential impact of structurally different anti-diabetic drugs on proliferation and chemosensitivity of acute lymphoblastic leukemia cells.

Cell cycle (Georgetown, Tex.) 20120615

A clinical trial to maintain glycemic control in youth with type 2 diabetes.

The New England journal of medicine 20120614

TODAY--a stark glimpse of tomorrow.

The New England journal of medicine 20120614

Defining the contribution of AMP-activated protein kinase (AMPK) and protein kinase C (PKC) in regulation of glucose uptake by metformin in skeletal muscle cells.

The Journal of biological chemistry 20120608

Metformin induces differentiation in acute promyelocytic leukemia by activating the MEK/ERK signaling pathway.

Biochemical and biophysical research communications 20120608

[Metformin associated with lactic acidosis in treatment of type 2 diabetes].

Ugeskrift for laeger 20120604

[Metformin-associated lactic acidosis can be treated with continuous renal replacement therapy].

Ugeskrift for laeger 20120604

[Treatment of metformin-associated lactate acidosis by haemodialysis].

Ugeskrift for laeger 20120604

Familial diabetes is associated with reduced risk of cancer in diabetic patients: a possible role for metformin.

Medical oncology (Northwood, London, England) 20120601

Metformin and cancer: new applications for an old drug.

Medical oncology (Northwood, London, England) 20120601

Metformin-associated lactic acidosis in a patient with normal kidney function.

Diabetes research and clinical practice 20120601

Myo-inositol may prevent gestational diabetes in PCOS women.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20120601

The increased dipeptidyl peptidase-4 activity is not counteracted by optimized glucose control in type 2 diabetes, but is lower in metformin-treated patients.

Diabetes, obesity & metabolism 20120601

Fenugreek attenuation of diabetic nephropathy in alloxan-diabetic rats: attenuation of diabetic nephropathy in rats.

Journal of physiology and biochemistry 20120601

Loss of multidrug and toxin extrusion 1 (MATE1) is associated with metformin-induced lactic acidosis.

British journal of pharmacology 20120601

Effect of antiandrogen treatment on bone density and bone geometry in adolescents with polycystic ovary syndrome.

Journal of pediatric and adolescent gynecology 20120601

Population pharmacokinetics of metformin in obese and non-obese patients with type 2 diabetes mellitus.

European journal of clinical pharmacology 20120601

Persistence with oral contraceptive pills versus metformin in women with polycystic ovary syndrome.

Journal of women's health (2002) 20120601

Metformin in cancer: translational challenges.

Journal of molecular endocrinology 20120601

Initial combination of linagliptin and metformin improves glycaemic control in type 2 diabetes: a randomized, double-blind, placebo-controlled study.

Diabetes, obesity & metabolism 20120601

Intensifying insulin therapy with insulin analog premixes: transitioning from basal insulin in type 2 diabetes.

Diabetes technology & therapeutics 20120601

Pregnancy outcomes and the effect of metformin treatment in women with polycystic ovary syndrome: an overview.

Acta obstetricia et gynecologica Scandinavica 20120601

Metformin inhibits growth and decreases resistance to anoikis in medullary thyroid cancer cells.

Endocrine-related cancer 20120601

AMP-activated protein kinase, stress responses and cardiovascular diseases.

Clinical science (London, England : 1979) 20120601

Combination therapy with metformin plus vildagliptin in type 2 diabetes mellitus.

Expert opinion on pharmacotherapy 20120601

Metformin for treatment of antipsychotic-induced weight gain: a randomized, placebo-controlled study.

Schizophrenia research 20120601

Metformin use among individuals at risk for type 2 diabetes.

Current diabetes reports 20120601

Ablation of both organic cation transporter (OCT)1 and OCT2 alters metformin pharmacokinetics but has no effect on tissue drug exposure and pharmacodynamics.

Drug metabolism and disposition: the biological fate of chemicals 20120601

Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice.

Pharmacology, biochemistry, and behavior 20120601

Atypical protein kinase C in cardiometabolic abnormalities.

Current opinion in lipidology 20120601

Determination of drug toxicity using 3D spheroids constructed from an immortal human hepatocyte cell line.

Toxicological sciences : an official journal of the Society of Toxicology 20120601

Luteinizing hormone facilitates angiogenesis in ovarian epithelial tumor cells and metformin inhibits the effect through the mTOR signaling pathway.

Oncology reports 20120601

Drug interactions with oral antidiabetic agents: pharmacokinetic mechanisms and clinical implications.

Trends in pharmacological sciences 20120601

Microvascular diseases: is a new era coming?

Cardiovascular & hematological agents in medicinal chemistry 20120601

The effect of metformin on the efficacy of antiviral therapy in patients with genotype 1 chronic hepatitis C and insulin resistance.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20120601

The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association.

Hepatology (Baltimore, Md.) 20120601

Cellular responses to the metal-binding properties of metformin.

Diabetes 20120601

Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to metformin in subjects with type 2 diabetes.

Diabetes care 20120601

Protein-tyrosine phosphatases are involved in interferon resistance associated with insulin resistance in HepG2 cells and obese mice.

The Journal of biological chemistry 20120601

Vildagliptin added to metformin on β-cell function after a euglycemic hyperinsulinemic and hyperglycemic clamp in type 2 diabetes patients.

Diabetes technology & therapeutics 20120601

The gonadal hormone regulates the plasma lactate levels in type 2 diabetes treated with and without metformin.

Diabetes technology & therapeutics 20120601

The role of combination therapy in type 2 diabetes in the post-ACCORD era.

Current diabetes reports 20120601

Inappropriate metformin prescribing in elderly type 2 diabetes mellitus (T2DM) patients.

Advances in medical sciences 20120601

Antidiabetic drug metformin suppresses endotoxin-induced uveitis in rats.

Investigative ophthalmology & visual science 20120601

Effect of different doses of metformin on serum testosterone and insulin in non-diabetic women with breast cancer: a randomized study.

Clinical breast cancer 20120601

Long-term effects of adding exenatide to a regimen of metformin and/or sulfonylurea in type 2 diabetes: an uncontrolled, open-label trial in Hungary.

Clinical therapeutics 20120601

Altering hirsutism through ovulation induction in women with polycystic ovary syndrome.

Obstetrics and gynecology 20120601

Statin is a reasonable treatment option for patients with Polycystic Ovary Syndrome: a meta-analysis of randomized controlled trials.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20120601

Cancer risk associated with use of metformin and sulfonylurea in type 2 diabetes: a meta-analysis.

The oncologist 20120601

Cardiovascular disease and oral agent glucose-lowering therapies in the management of type 2 diabetes.

Diabetes technology & therapeutics 20120601

Glibenclamide-pregnenolone derivative has greater hypoglycemic effects and biodistribution than glibenclamide-OH in alloxan-rats.

Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 20120601

Effect of insulin sensitizer therapy on atherothrombotic and inflammatory profiles associated with insulin resistance.

Mayo Clinic proceedings 20120601

Does metformin increase paraoxonase activity in patients with the metabolic syndrome? Additional data from the MEFISTO study.

Clinical and translational science 20120601

Metformin elicits anticancer effects through the sequential modulation of DICER and c-MYC.

Nature communications 20120529

Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility.

The Cochrane database of systematic reviews 20120516

[Prevention of type 2 diabetes mellitus].

MMW Fortschritte der Medizin 20120516

Metformin and pancreatic cancer: a clue requiring investigation.

Clinical cancer research : an official journal of the American Association for Cancer Research 20120515

Metformin use is associated with better survival of diabetic patients with pancreatic cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research 20120515

Evaluation of guidelines on diabetes medication.

Annals of internal medicine 20120515

Evaluation of guidelines on diabetes medication.

Annals of internal medicine 20120515

Discrepancies among consensus documents, guidelines, clinical practice and the legal framework for the treatment of type 2 diabetes mellitus patients.

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20120514

Inhibition of hepatic uptake transporters by flavonoids.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120512

Metformin-induced AMP-activated protein kinase activation regulates phenylephrine-mediated contraction of rat aorta.

Biochemical and biophysical research communications 20120511

Investigation of an active film coating to prepare new fixed-dose combination tablets for treatment of diabetes.

International journal of pharmaceutics 20120510

[Relationship between the degree of glycemic control and diabetes characteristics and hyperglycemia treatment in type 2 diabetes. DIABES Study].

Medicina clinica 20120505

Effects of metformin on oxidative stress, adenine nucleotides balance, and glucose-induced insulin release impaired by chronic free fatty acids exposure in rat pancreatic islets.

Journal of endocrinological investigation 20120501

A prospective, randomized pilot study evaluating the effects of metformin and lifestyle intervention on patients with prostate cancer receiving androgen deprivation therapy.

BJU international 20120501

Lifestyle intervention improves fitness independent of metformin in obese adolescents.

Medicine and science in sports and exercise 20120501

Initial therapy with the fixed-dose combination of sitagliptin and metformin results in greater improvement in glycaemic control compared with pioglitazone monotherapy in patients with type 2 diabetes.

Diabetes, obesity & metabolism 20120501

Metformin alters the expression profiles of microRNAs in human pancreatic cancer cells.

Diabetes research and clinical practice 20120501

Metformin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and modulation of the mTOR pathway.

Gynecologic oncology 20120501

Chronic GLP-1 receptor activation by exendin-4 induces expansion of pancreatic duct glands in rats and accelerates formation of dysplastic lesions and chronic pancreatitis in the Kras(G12D) mouse model.

Diabetes 20120501

MicroRNA-21-mediated regulation of Sprouty2 protein expression enhances the cytotoxic effect of 5-fluorouracil and metformin in colon cancer cells.

International journal of molecular medicine 20120501

Biowaiver approach for biopharmaceutics classification system class 3 compound metformin hydrochloride using in silico modeling.

Journal of pharmaceutical sciences 20120501

Metformin ameliorates IL-6-induced hepatic insulin resistance via induction of orphan nuclear receptor small heterodimer partner (SHP) in mouse models.

Diabetologia 20120501

Metformin-associated lactic acidosis masquerading as ischemic bowel.

The American journal of medicine 20120501

Pro12Ala polymorphism of the PPAR-γ2 gene, metabolic syndrome and response to metformin in clozapine-treated patients.

Schizophrenia research 20120501

Dapagliflozin, metformin XR, or both: initial pharmacotherapy for type 2 diabetes, a randomised controlled trial.

International journal of clinical practice 20120501

Pharmacokinetic and pharmacodynamic interaction between nifedipine and metformin in rats: competitive inhibition for metabolism of nifedipine and metformin by each other via CYP isozymes.

Xenobiotica; the fate of foreign compounds in biological systems 20120501

Metformin improves pregnancy and live-birth rates in women with polycystic ovary syndrome (PCOS): a multicenter, double-blind, placebo-controlled randomized trial.

The Journal of clinical endocrinology and metabolism 20120501

Efficacy and tolerability of the DPP-4 inhibitor alogliptin combined with pioglitazone, in metformin-treated patients with type 2 diabetes.

The Journal of clinical endocrinology and metabolism 20120501

Initiation of sulfonylureas versus metformin is associated with higher blood pressure at one year.

Pharmacoepidemiology and drug safety 20120501

Glycemic control over 5 years in 4,900 people with type 2 diabetes: real-world diabetes therapy in a clinical trial cohort.

Diabetes care 20120501

Soluble platelet/endothelial cell adhesion molecule (sPECAM)-1 is increased in polycystic ovary syndrome and related to endothelial dysfunction.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20120501

Statin use as a moderator of metformin effect on risk for prostate cancer among type 2 diabetic patients.

Diabetes care 20120501

Metformin, other antidiabetic drugs, and risk of Alzheimer's disease: a population-based case-control study.

Journal of the American Geriatrics Society 20120501

Worry vs. knowledge about treatment-associated hypoglycaemia and weight gain in type 2 diabetic patients on metformin and/or sulphonylurea.

Current medical research and opinion 20120501

A systematic review and meta-analysis of randomized controlled trials comparing pioglitazone versus metformin in the treatment of polycystic ovary syndrome.

Current medical research and opinion 20120501

High-performance liquid chromatography quadrupole time-of-flight mass spectrometry method for the analysis of antidiabetic drugs in aqueous environmental samples.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120501

Therapeutic effects of calcium & vitamin D supplementation in women with PCOS.

Complementary therapies in clinical practice 20120501

Endometrial shedding effect on conception and live birth in women with polycystic ovary syndrome.

Obstetrics and gynecology 20120501

Reweighted Mahalanobis distance matching for cluster-randomized trials with missing data.

Pharmacoepidemiology and drug safety 20120501

Metformin in obesity, cancer and aging: addressing controversies.

Aging 20120501

Metformin and the mTOR inhibitor everolimus (RAD001) sensitize breast cancer cells to the cytotoxic effect of chemotherapeutic drugs in vitro.

Anticancer research 20120501

A retrospective in vitro study of the impact of anti-diabetics and cardioselective pharmaceuticals on breast cancer.

Anticancer research 20120501

[Metformin-associated lactic acidosis: incidence, diagnosis, prognostic factors and treatment].

Revista espanola de anestesiologia y reanimacion 20120501

[Medicines for type 2 diabetes: fine tuning rather than redesign].

Medizinische Monatsschrift fur Pharmazeuten 20120501

[Biguanide].

Nihon rinsho. Japanese journal of clinical medicine 20120501

Association between sitagliptin adherence and self-monitoring of blood glucose.

Journal of diabetes science and technology 20120501

In type 2 diabetes patients, insulin glargine is associated with lower postprandial release of intact proinsulin compared with sulfonylurea treatment.

Journal of diabetes science and technology 20120501

Bioassay-guided antidiabetic study of Phaleria macrocarpa fruit extract.

Molecules (Basel, Switzerland) 20120430

[Vitamin B12 deficiency in diabetic patients taking metformin].

Medicina clinica 20120428

Report was overpositive about their benefits.

BMJ (Clinical research ed.) 20120424

Prescribed with gusto despite 'uncertain' benefits.

BMJ (Clinical research ed.) 20120424

Comparison of metformin and insulin versus insulin alone for type 2 diabetes: systematic review of randomised clinical trials with meta-analyses and trial sequential analyses.

BMJ (Clinical research ed.) 20120419

Survival advantage observed with the use of metformin in patients with type II diabetes and colorectal cancer.

British journal of cancer 20120410

A phase I study of temsirolimus and metformin in advanced solid tumours.

Investigational new drugs 20120401

Initiation of insulin among veterans with type 2 diabetes and sustained elevation of A1c.

Primary care diabetes 20120401

Adherence to hypoglycaemic medication among people with type 2 diabetes in primary care.

Primary care diabetes 20120401

Inhibition of p42 MAPK using a nonviral vector-delivered siRNA potentiates the anti-tumor effect of metformin in prostate cancer cells.

Nanomedicine (London, England) 20120401

Longitudinal change in HbA1c after insulin initiation in primary care patients with type 2 diabetes: a database analysis in UK and Germany.

Primary care diabetes 20120401

Adding saxagliptin to extended-release metformin vs. uptitrating metformin dosage.

Diabetes, obesity & metabolism 20120401

DPP-4 inhibitors in the management of type 2 diabetes: a critical review of head-to-head trials.

Diabetes & metabolism 20120401

Addition of insulin glargine or NPH insulin to metformin monotherapy in poorly controlled type 2 diabetic patients decreases IGF-I bioactivity similarly.

Diabetologia 20120401

Effect of metformin on the proliferation, migration, and MMP-2 and -9 expression of human umbilical vein endothelial cells.

Molecular medicine reports 20120401

Comparative effectiveness of incident oral antidiabetic drugs on kidney function.

Kidney international 20120401

Metformin reduces endogenous reactive oxygen species and associated DNA damage.

Cancer prevention research (Philadelphia, Pa.) 20120401

Distinct effects of pioglitazone and metformin on circulating sclerostin and biochemical markers of bone turnover in men with type 2 diabetes mellitus.

European journal of endocrinology 20120401

Metformin inhibits growth of thyroid carcinoma cells, suppresses self-renewal of derived cancer stem cells, and potentiates the effect of chemotherapeutic agents.

The Journal of clinical endocrinology and metabolism 20120401

Use of antidiabetic agents and the risk of pancreatic cancer: a case-control analysis.

The American journal of gastroenterology 20120401

Effect of saxagliptin as add-on therapy in patients with poorly controlled type 2 diabetes on insulin alone or insulin combined with metformin.

Current medical research and opinion 20120401

Dipeptidyl peptidase-4 inhibitors: 3 years of experience.

Diabetes technology & therapeutics 20120401

Anti-diabetic activities of Acanthopanax senticosus polysaccharide (ASP) in combination with metformin.

International journal of biological macromolecules 20120401

Antidiabetic drug metformin alleviates endotoxin-induced fulminant liver injury in mice.

International immunopharmacology 20120401

Metformin prevents the development of chronic heart failure in the SHHF rat model.

Diabetes 20120401

Metformin reduces vascular production of vasoconstrictor prostanoids in fructose overloaded rats.

Autonomic & autacoid pharmacology 20120401

KCNJ11 gene E23K variant and therapeutic response to sulfonylureas.

European journal of internal medicine 20120401

Reply to: Ahren B et al. Mechanisms of action of the dipeptidyl peptidase-4 inhibitor vildagliptin in humans. Diabetes Obes Metab 2011; 13(9): 775-783 and Ahren B et al. Clinical evidence and mechanistic basis for vildagliptin's action when added to metformin. Diabetes Obes Metab 2011; 13(3): 193-203.

Diabetes, obesity & metabolism 20120401

The design of the liraglutide clinical trial programme.

Diabetes, obesity & metabolism 20120401

Liraglutide: from clinical trials to clinical practice.

Diabetes, obesity & metabolism 20120401

Metformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt/β-catenin signaling.

Cancer prevention research (Philadelphia, Pa.) 20120401

Genetic variants of organic cation transporter 1 (OCT1) and OCT2 significantly reduce lamivudine uptake.

Biopharmaceutics & drug disposition 20120401

Metformin suppresses growth of human head and neck squamous cell carcinoma via global inhibition of protein translation.

Cell cycle (Georgetown, Tex.) 20120401

Steps toward the meaningful translation of prevention strategies for type 2 diabetes.

Diabetes care 20120401

The 10-year cost-effectiveness of lifestyle intervention or metformin for diabetes prevention: an intent-to-treat analysis of the DPP/DPPOS.

Diabetes care 20120401

Long-term safety, tolerability, and weight loss associated with metformin in the Diabetes Prevention Program Outcomes Study.

Diabetes care 20120401

Metformin and hepatic carcinogenesis.

Cancer prevention research (Philadelphia, Pa.) 20120401

Metformin prevents liver tumorigenesis by inhibiting pathways driving hepatic lipogenesis.

Cancer prevention research (Philadelphia, Pa.) 20120401

Metformin prevents the development of oral squamous cell carcinomas from carcinogen-induced premalignant lesions.

Cancer prevention research (Philadelphia, Pa.) 20120401

Prevention of mutagenesis: new potential mechanisms of metformin action in neoplastic cells.

Cancer prevention research (Philadelphia, Pa.) 20120401

Reappraisal of metformin efficacy in the treatment of type 2 diabetes: a meta-analysis of randomised controlled trials.

PLoS medicine 20120401

Recommendations for improving adherence to type 2 diabetes mellitus therapy--focus on optimizing oral and non-insulin therapies.

The American journal of managed care 20120401

The role of the nurse practitioner in the diagnosis and early management of type 2 diabetes.

Journal of the American Academy of Nurse Practitioners 20120401

Therapeutic choices, and the nurse practitioner's role, in type 2 diabetes when metformin alone is no longer enough.

Journal of the American Academy of Nurse Practitioners 20120401

Insulin initiation in type 2 diabetes: what are the treatment regimen options and how can we best help patients feel empowered?

Journal of the American Academy of Nurse Practitioners 20120401

Metformin-induced preferential killing of breast cancer initiating CD44+CD24-/low cells is sufficient to overcome primary resistance to trastuzumab in HER2+ human breast cancer xenografts.

Oncotarget 20120401

Metformin accelerates the growth of BRAF V600E-driven melanoma by upregulating VEGF-A.

Cancer discovery 20120401

Lactic acidosis in a diabetic patient treated with metformin undergoing hepatic resection.

British journal of hospital medicine (London, England : 2005) 20120401

Competitive CE-UV binding tests for selective recognition of bisphenol A by molecularly imprinted polymer particles.

Electrophoresis 20120401

Hepatorenal repercussions of alcoholic exposure in a rat model: a dose-dependent study of metformin intervention.

Iranian biomedical journal 20120401

The role of ATM in response to metformin treatment and activation of AMPK.

Nature genetics 20120328

The role of ATM in response to metformin treatment and activation of AMPK.

Nature genetics 20120328

The role of ATM in response to metformin treatment and activation of AMPK.

Nature genetics 20120328

The effect of metformin on food intake and its potential role in hypothalamic regulation in obese diabetic rats.

Brain research 20120320

Metformin lowers the threshold for stress-induced senescence: a role for the microRNA-200 family and miR-205.

Cell cycle (Georgetown, Tex.) 20120315

Effects of lifestyle modification and metformin on atherosclerotic indices among HIV-infected patients with the metabolic syndrome.

AIDS (London, England) 20120313

Phenformin as prophylaxis and therapy in breast cancer xenografts.

British journal of cancer 20120313

The role of dipeptidyl peptidase-4 inhibitors.

BMJ (Clinical research ed.) 20120312

Dipeptidyl peptidase-4 inhibitors for treatment of type 2 diabetes mellitus in the clinical setting: systematic review and meta-analysis.

BMJ (Clinical research ed.) 20120312

Disposition of metformin: variability due to polymorphisms of organic cation transporters.

Annals of medicine 20120301

Familial occurrence of neonatal diabetes with duplications in chromosome 6q24: treatment with sulfonylurea and 40-yr follow-up.

Pediatric diabetes 20120301

Effect of metformin on survival outcomes in diabetic patients with triple receptor-negative breast cancer.

Cancer 20120301

Diagnosis and therapy of polycystic ovarian syndrome: results of a survey among German gynecologists with a review on literature.

Archives of gynecology and obstetrics 20120301

Impaired gallbladder motility and the effect of metformin therapy in patients with polycystic ovary syndrome.

Clinical endocrinology 20120301

Cost-utility analysis of liraglutide compared with sulphonylurea or sitagliptin, all as add-on to metformin monotherapy in Type 2 diabetes mellitus.

Diabetic medicine : a journal of the British Diabetic Association 20120301

Effects of a combination of oral anti-diabetes drugs with basal insulin therapy on β-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes.

Diabetes/metabolism research and reviews 20120301

Discontinuation of statins among patients with type 2 diabetes.

Diabetes/metabolism research and reviews 20120301

Improved gall bladder motility in PCOS women treated with metformin--interaction of free fatty acids with circulating cholecystokinin?

Clinical endocrinology 20120301

Metformin after bariatric surgery--an acid problem.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20120301

Efficacy of metformin for prevention of weight gain in psychiatric populations: a review.

International clinical psychopharmacology 20120301

The impact of initiating biphasic human insulin 30 therapy in type 2 diabetes patients after failure of oral antidiabetes drugs.

Diabetes technology & therapeutics 20120301

Optimization of a dual mechanism gastrofloatable and gastroadhesive delivery system for narrow absorption window drugs.

AAPS PharmSciTech 20120301

Reduction of insulin signaling upregulates angiopoietin-like protein 4 through elevated free fatty acids in diabetic mice.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20120301

Altered redox homeostasis in human diabetes saliva.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20120301

Comparing the effects of insulin glargine and thiazolidinediones on plasma lipids in type 2 diabetes: a patient-level pooled analysis.

Diabetes/metabolism research and reviews 20120301

Metformin inhibits cell proliferation, migration and invasion by attenuating CSC function mediated by deregulating miRNAs in pancreatic cancer cells.

Cancer prevention research (Philadelphia, Pa.) 20120301

Beneficial effects of metformin and irbesartan on advanced glycation end products (AGEs)-RAGE-induced proximal tubular cell injury.

Pharmacological research 20120301

Metformin differentially activates ER stress signaling pathways without inducing apoptosis.

Disease models & mechanisms 20120301

Rosiglitazone and metformin have opposite effects on intestinal absorption of oligopeptides via the proton-dependent PepT1 transporter.

Molecular pharmacology 20120301

Cellular and molecular mechanisms of metformin: an overview.

Clinical science (London, England : 1979) 20120301

Antihyperglycemic and antihyperlipidemic effect of Santalum album in streptozotocin induced diabetic rats.

Pharmaceutical biology 20120301

Interactions between tumor cells and microenvironment in breast cancer: a new opportunity for targeted therapy.

Cancer science 20120301

Fetuin A in nonalcoholic fatty liver disease: in vivo and in vitro studies.

European journal of endocrinology 20120301

Anti-hyperglycemic and anti-hypercholesterolemic effects of Aloe vera leaf gel in hyperlipidemic type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial.

Planta medica 20120301

A humanized anti-IGF-1R monoclonal antibody (R1507) and/or metformin enhance gemcitabine-induced apoptosis in pancreatic cancer cells.

Oncology reports 20120301

Weight loss/maintenance as an effective tool for controlling type 2 diabetes: novel methodology to sustain weight reduction.

Diabetes/metabolism research and reviews 20120301

Insulin glargine and risk of cancer: a cohort study in the French National Healthcare Insurance Database.

Diabetologia 20120301

The antidiabetic drug metformin inhibits gastric cancer cell proliferation in vitro and in vivo.

Molecular cancer therapeutics 20120301

Overfed Ossabaw swine with early stage metabolic syndrome have normal coronary collateral development in response to chronic ischemia.

Basic research in cardiology 20120301

Potential risks of metformin in transplant patients.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20120301

Effects of dapagliflozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin.

The Journal of clinical endocrinology and metabolism 20120301

Type 2 diabetes and obesity metabolic interactions: common factors for breast cancer risk and novel approaches to prevention and therapy.

Current diabetes reviews 20120301

Polycystic kidney disease: a 2011 update.

Current opinion in nephrology and hypertension 20120301

Cost effectiveness of saxagliptin and metformin versus sulfonylurea and metformin in the treatment of type 2 diabetes mellitus in Germany: a Cardiff diabetes model analysis.

Clinical drug investigation 20120301

Metformin versus lifestyle changes in treating women with polycystic ovary syndrome.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20120301

Saxagliptin plus metformin combination in patients with type 2 diabetes and renal impairment.

Expert opinion on drug metabolism & toxicology 20120301

Activation of AMP-activated protein kinase (AMPK) provides a metabolic barrier to reprogramming somatic cells into stem cells.

Cell cycle (Georgetown, Tex.) 20120301

Metformin rescues cell surface major histocompatibility complex class I (MHC-I) deficiency caused by oncogenic transformation.

Cell cycle (Georgetown, Tex.) 20120301

Patterns of medication initiation in newly diagnosed diabetes mellitus: quality and cost implications.

The American journal of medicine 20120301

Metformin-induced hepatotoxicity.

Diabetes care 20120301

Comment on: Rowan et al. Metformin in Gestational diabetes: The Offspring Follow-Up (MiG TOFU): body composition at 2 years of age. Diabetes Care 2011;34:2279-2284.

Diabetes care 20120301

Comment on: Rowan et al. Metformin in Gestational diabetes: The Offspring Follow-Up (MiG TOFU): body composition at 2 years of age. Diabetes Care 2011;34:2279-2284.

Diabetes care 20120301

Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy.

Cell death & disease 20120301

Low hemoglobin A(1c)--good diabetic control?

Clinical chemistry 20120301

Incretin-based therapies in clinical practice: from efficacy to effectiveness. Focus on liraglutide.

Minerva endocrinologica 20120301

Neuroendocrine and endocrine dysfunction in the hyperinsulinemic PCOS patient: the role of metformin.

Minerva endocrinologica 20120301

Menopausal obesity and metabolic syndrome - PolSenior study.

Minerva endocrinologica 20120301

Metformin and cancer stem cells: old drug, new targets.

Cancer prevention research (Philadelphia, Pa.) 20120301

The work-up for mixed hyperlipidemia: a case study.

The Journal of family practice 20120301

Antidiabetic and antioxidant effect of Semecarpus anacardium Linn. nut milk extract in a high-fat diet STZ-induced type 2 diabetic rat model.

Journal of dietary supplements 20120301

Better care for PCOS. Studying women's genes to find out what works.

Diabetes forecast 20120301

Design and in vitro and in vivo characterization of mucoadhesive matrix pellets of metformin hydrochloride for oral controlled release: a technical note.

Archives of pharmacal research 20120301

[Use of insulin sensitizers in the treatment of infertility in patients with polycystic ovary syndrome (POS)].

Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia 20120301

Prescription patterns for diabetes mellitus and therapeutic implications: a population-based analysis.

Arquivos brasileiros de endocrinologia e metabologia 20120301

Comparing the efficacy and safety profile of sitagliptin versus glimepiride in patients of type 2 diabetes mellitus inadequately controlled with metformin alone.

The Journal of the Association of Physicians of India 20120301

Metformin associated B12 deficiency.

The Journal of the Association of Physicians of India 20120301

Role of angiotensin II-mediated AMPK inactivation on obesity-related salt-sensitive hypertension.

Biochemical and biophysical research communications 20120217

Antidiabetic effect of total saponins from Entada phaseoloides (L.) Merr. in type 2 diabetic rats.

Journal of ethnopharmacology 20120215

Oral pharmacologic treatment of type 2 diabetes mellitus: a clinical practice guideline from the American College of Physicians.

Annals of internal medicine 20120207

Summaries for patients: Oral drug treatment of type 2 diabetes mellitus: a clinical practice guideline from the American College of Physicians.

Annals of internal medicine 20120207

Drug-induced bullous pemphigoid in diabetes mellitus patients receiving dipeptidyl peptidase-IV inhibitors plus metformin.

Journal of the European Academy of Dermatology and Venereology : JEADV 20120201

Linearization of the MS response function: case study for metformin assay in plasma samples for bioequivalence purposes.

Biomedical chromatography : BMC 20120201

Assessment of treatment algorithms including amantadine, metformin, and zonisamide for the prevention of weight gain with olanzapine: a randomized controlled open-label study.

The Journal of clinical psychiatry 20120201

Metformin as a cause of high stomal output.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 20120201

Metformin administration in patients with polycystic ovary syndrome who receive gonadotropins for in vitro fertilization cycles: 10-year experience in a large infertile population.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20120201

Metformin-induced leukocytoclastic vasculitis: a case report.

American journal of clinical dermatology 20120201

Diabetes mellitus and risk of hepatocellular carcinoma: a systematic review and meta-analysis.

Diabetes/metabolism research and reviews 20120201

ENPP1 mRNA levels in white blood cells and prediction of metformin efficacy in type 2 diabetic patients: a preliminary evidence.

Nutrition, metabolism, and cardiovascular diseases : NMCD 20120201

Targeting AMPK in the treatment of malignancies.

Journal of cellular biochemistry 20120201

Metformin-associated lactic acidosis following acute kidney injury. Efficacious treatment with continuous renal replacement therapy.

Diabetic medicine : a journal of the British Diabetic Association 20120201

Type 2 diabetes, metformin and lactic acidosis-defining the risk and promoting safe practice.

Diabetic medicine : a journal of the British Diabetic Association 20120201

Metformin-treated patients with type 2 diabetes have normal mitochondrial complex I respiration.

Diabetologia 20120201

Telecare Provides comparable efficacy to conventional self-monitored blood glucose in patients with type 2 diabetes titrating one injection of insulin glulisine-the ELEONOR study.

Diabetes technology & therapeutics 20120201

Unlicensed use of metformin in children and adolescents in Germany and France.

British journal of clinical pharmacology 20120201

Gestational diabetes: implications for cardiovascular health.

Current diabetes reports 20120201

Caveolin-1 is essential for metformin inhibitory effect on IGF1 action in non-small-cell lung cancer cells.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20120201

Metformin causes nitric oxide-mediated dilatation in a shorter time than insulin in the iliac artery of the anesthetized pig.

Journal of cardiovascular pharmacology 20120201

Competitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney.

The Journal of pharmacology and experimental therapeutics 20120201

Metformin may antagonize Lin28 and/or Lin28B activity, thereby boosting let-7 levels and antagonizing cancer progression.

Medical hypotheses 20120201

Chemoprevention in colorectal cancer--where we stand and what we have learned from twenty year's experience.

The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland 20120201

Introduction of metformin for gestational diabetes mellitus in clinical practice: Has it had an impact?

European journal of obstetrics, gynecology, and reproductive biology 20120201

Management of diabetes in pregnancy.

Current diabetes reports 20120201

Medical therapy for nonalcoholic fatty liver disease in children and adolescents.

Expert review of gastroenterology & hepatology 20120201

Androgens and antimüllerian hormone in mothers with polycystic ovary syndrome and their newborns.

Fertility and sterility 20120201

Large enhancement of skeletal muscle cell glucose uptake and suppression of hepatocyte glucose-6-phosphatase activity by weak uncouplers of oxidative phosphorylation.

Biochimica et biophysica acta 20120201

Use of metformin is not associated with a decreased risk of colorectal cancer: a case-control analysis.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20120201

Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program.

Diabetes care 20120201

Association of biochemical B₁₂ deficiency with metformin therapy and vitamin B₁₂ supplements: the National Health and Nutrition Examination Survey, 1999-2006.

Diabetes care 20120201

Acute renal failure after intragastric balloon in morbidly-obese metformin-treated diabetic patients. Report of two cases.

Nutrition, metabolism, and cardiovascular diseases : NMCD 20120201

Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naive patients with type 2 diabetes (DURATION-4): a 26-week double-blind study.

Diabetes care 20120201

Pharmacokinetics of a fixed-dose glimepiride/sustained-release metformin combination.

International journal of clinical pharmacology and therapeutics 20120201

Mortality after incident cancer in people with and without type 2 diabetes: impact of metformin on survival.

Diabetes care 20120201

Rapid recovery from acute kidney injury in a patient with metformin-associated lactic acidosis and hypothermia.

The American journal of medicine 20120201

Metformin: a potential novel endometrial cancer therapy.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20120201

Quantifying the effect of metformin treatment and dose on glycemic control.

Diabetes care 20120201

Highlights from the latest articles in diabetes pharmacogenomics.

Pharmacogenomics 20120201

Male partial hypogonadotrophic hypogonadism with gynaecomastia and metabolic syndrome.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 20120201

[Diet, metformin and inositol in overweight and obese women with polycystic ovary syndrome: effects on body composition].

Minerva ginecologica 20120201

Fixed-dose glucose-lowering drug combinations: preventable lactic acidosis.

Prescrire international 20120201

Hypoglycemic effect and mechanism of a proteoglycan from ganoderma lucidum on streptozotocin-induced type 2 diabetic rats.

European review for medical and pharmacological sciences 20120201

Does use of metformin protect against cancer in Type 2 diabetes mellitus?

Journal of endocrinological investigation 20120201

[Metformin improves epididymal sperm quality and antioxidant function of the testis in diet-induced obesity rats].

Zhonghua nan ke xue = National journal of andrology 20120201

Glycaemic control and cost analysis when changing from gliclazide co-administered with metformin to pre-combined glibenclamide-metformin tablets in type 2 diabetes mellitus.

The Medical journal of Malaysia 20120201

Improvement of metabolic parameters and vascular function by metformin in obese non-diabetic rats.

Life sciences 20120130

Global gene expression profiling in mouse plasma cell tumor precursor and bystander cells reveals potential intervention targets for plasma cell neoplasia.

Blood 20120126

Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers.

Cell cycle (Georgetown, Tex.) 20120115

Energy-sensing factors coactivator peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) and AMP-activated protein kinase control expression of inflammatory mediators in liver: induction of interleukin 1 receptor antagonist.

The Journal of biological chemistry 20120113

Perinatal impact of the use of metformin and glyburide for the treatment of gestational diabetes mellitus.

Journal of perinatal medicine 20120110

Metformin prevents endoplasmic reticulum stress-induced apoptosis through AMPK-PI3K-c-Jun NH2 pathway.

Biochemical and biophysical research communications 20120106

Cancer research. Cancer prevention with a diabetes pill?

Science (New York, N.Y.) 20120106

Evaluation of guideline recommendations on oral medications for type 2 diabetes mellitus: a systematic review.

Annals of internal medicine 20120103

Metformin and phenformin block the peripheral antinociception induced by diclofenac and indomethacin on the formalin test.

Life sciences 20120102

The effect of oral metformin on insulin sensitivity in insulin-resistant ponies.

Veterinary journal (London, England : 1997) 20120101

Determination of metformin and other biguanides in forensic whole blood samples by hydrophilic interaction liquid chromatography-electrospray tandem mass spectrometry.

Biomedical chromatography : BMC 20120101

Lupin seed γ-conglutin lowers blood glucose in hyperglycaemic rats and increases glucose consumption of HepG2 cells.

The British journal of nutrition 20120101

Metformin and improvement of the hepatic insulin resistance index independent of anthropometric changes.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20120101

Caloric restriction and chronic inflammatory diseases.

Oral diseases 20120101

Weight loss significantly reduces serum lipocalin-2 levels in overweight and obese women with polycystic ovary syndrome.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20120101

Unlicensed use of metformin in children and adolescents in the UK.

British journal of clinical pharmacology 20120101

Metformin induced expression of Hsp60 in human THP-1 monocyte cells.

Cell stress & chaperones 20120101

Predictive value of HbA1c for incident diabetes among subjects with impaired glucose tolerance--analysis of the Indian Diabetes Prevention Programmes.

Diabetic medicine : a journal of the British Diabetic Association 20120101

Cancer mortality reduction and metformin: a retrospective cohort study in type 2 diabetic patients.

Diabetes, obesity & metabolism 20120101

Discordant effects on central obesity, hepatic insulin resistance, and alanine aminotransferase of low-dose metformin and thiazolidinedione combination therapy in patients with impaired glucose tolerance.

Diabetes, obesity & metabolism 20120101

Potentially inappropriate prescribing (IP) for elderly medical inpatients in Taiwan: a hospital-based study.

Archives of gerontology and geriatrics 20120101

Metformin in equine metabolic syndrome: an enigma or a dead duck?

Veterinary journal (London, England : 1997) 20120101

Metformin and neoplasia: implications and indications.

Pharmacology & therapeutics 20120101

Effect of metformin therapy on vitamin D and vitamin B₁₂ levels in patients with type 2 diabetes mellitus.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20120101

Discontinuation of metformin in the setting of coronary angiography: clinical uncertainty amongst physicians reflecting a poor evidence base.

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 20120101

Microarray expression analysis in delayed cardioprotection: the effect of exercise, AICAR, or metformin and the possible role of AMP-activated protein kinase (AMPK).

Molecular and cellular biochemistry 20120101

AMP-dependent kinase/mammalian target of rapamycin complex 1 signaling in T-cell acute lymphoblastic leukemia: therapeutic implications.

Leukemia 20120101

Atorvastatin therapy decreases androstenedione and dehydroepiandrosterone sulphate concentrations in patients with polycystic ovary syndrome: randomized controlled study.

Annals of clinical biochemistry 20120101

Effects of pioglitazone add-on to gliclazide and metformin on glycemic control in patients with type 2 diabetes.

Endocrine research 20120101

Metformin effects revisited.

Diabetes research and clinical practice 20120101

Addition of metformin to sildenafil treatment for erectile dysfunction in eugonadal nondiabetic men with insulin resistance. A prospective, randomized, double-blind pilot study.

Journal of andrology 20120101

A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome.

European journal of endocrinology 20120101

Independent and combined effects of exercise training and metformin on insulin sensitivity in individuals with prediabetes.

Diabetes care 20120101

Effects of pioglitazone and metformin on vascular endothelial function in patients with type 2 diabetes treated with sulfonylureas.

Diabetes & vascular disease research 20120101

Effect of initial combination therapy with sitagliptin and metformin on β-cell function in patients with type 2 diabetes.

Diabetes, obesity & metabolism 20120101

Can a protocol for glycaemic control improve type 2 diabetes outcomes after gastric bypass?

Obesity surgery 20120101

The safety, efficacy and predictors for HbA1c reduction of sitagliptin in the treatment of Japanese type 2 diabetes.

Diabetes research and clinical practice 20120101

The cost-effectiveness of saxagliptin versus NPH insulin when used in combination with other oral antidiabetes agents in the treatment of type 2 diabetes mellitus in Poland.

Diabetes technology & therapeutics 20120101

Successful treatment of prediabetes in clinical practice: targeting insulin resistance and β-cell dysfunction.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20120101

Reversible severe deterioration of glycaemic control after withdrawal of metformin treatment.

Diabetologia 20120101

LY294002 and metformin cooperatively enhance the inhibition of growth and the induction of apoptosis of ovarian cancer cells.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20120101

Improvement of hyperandrogenism and hyperinsulinemia during pregnancy in women with polycystic ovary syndrome: possible effect in the ovarian follicular mass of their daughters.

Fertility and sterility 20120101

Lower risk of cancer in patients on metformin in comparison with those on sulfonylurea derivatives: results from a large population-based follow-up study.

Diabetes care 20120101

Metformin and cancer therapy.

Current opinion in oncology 20120101

Sirtuin 1-mediated cellular metabolic memory of high glucose via the LKB1/AMPK/ROS pathway and therapeutic effects of metformin.

Diabetes 20120101

Metformin and heart failure: never say never again.

Expert opinion on pharmacotherapy 20120101

Metformin + saxagliptin for type 2 diabetes.

Expert opinion on pharmacotherapy 20120101

Spontaneous platelet aggregation evaluated by laser light scatter in patients with type 2 diabetes: effects of short-term improved glycemic control and adiponectin.

Translational research : the journal of laboratory and clinical medicine 20120101

Serum level of soluble CD26/dipeptidyl peptidase-4 (DPP-4) predicts the response to sitagliptin, a DPP-4 inhibitor, in patients with type 2 diabetes controlled inadequately by metformin and/or sulfonylurea.

Translational research : the journal of laboratory and clinical medicine 20120101

Diabetes and pancreatic cancer.

Molecular carcinogenesis 20120101

Relationship of type II diabetes and metformin use to ovarian cancer progression, survival, and chemosensitivity.

Obstetrics and gynecology 20120101

For what reasons should metformin be used in the management of polycystic ovary syndrome?

Journal of endocrinological investigation 20120101

Should all women with PCOS be treated for insulin resistance?

Fertility and sterility 20120101

Postmarketing pharmacovigilance of adverse drug reactions: the case of rosiglitazone in Mexico.

International journal of clinical pharmacology and therapeutics 20120101

Metabolic compartments in tumor tissue: implications for therapy.

Cell cycle (Georgetown, Tex.) 20120101

The role of metformin in the management of NAFLD.

Experimental diabetes research 20120101

Proton pump inhibitor therapy associated with lower glycosylated hemoglobin levels in type 2 diabetes.

Journal of the American Board of Family Medicine : JABFM 20120101

Fixed-dose combination antidiabetic therapy: real-world factors associated with prescribing choices and relationship with patient satisfaction and compliance.

Advances in therapy 20120101

Neuroprotection with metformin and thymoquinone against ethanol-induced apoptotic neurodegeneration in prenatal rat cortical neurons.

BMC neuroscience 20120101

Quantifying the impact of drug exposure misclassification due to restrictive drug coverage in administrative databases: a simulation cohort study.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20120101

Variation in CDKAL1 gene is associated with therapeutic response to sulphonylureas.

Physiological research 20120101

Persistence of initial oral antidiabetic treatment in patients with type 2 diabetes mellitus.

Medical science monitor : international medical journal of experimental and clinical research 20120101

Outcome of metformin treatment in polycystic ovary syndrome.

Mymensingh medical journal : MMJ 20120101

Bioequivalence and pharmacokinetic comparison of 3 metformin extended/sustained release tablets in healthy Indian male volunteers.

Arzneimittel-Forschung 20120101

Intracerebroventricular administration of metformin inhibits ghrelin-induced Hypothalamic AMP-kinase signalling and food intake.

Neuroendocrinology 20120101

Treating polycystic ovary syndrome and infertility.

MCN. The American journal of maternal child nursing 20120101

AMP-activated protein kinase plays an important evolutionary conserved role in the regulation of glucose metabolism in fish skeletal muscle cells.

PloS one 20120101

Iodine-based radiographic contrast medium may precipitate metformin-associated lactic acidosis in diabetic patients. A case report, literature review and practical approach.

La Clinica terapeutica 20120101

Therapeutic trial of metformin and bortezomib in a mouse model of tuberous sclerosis complex (TSC).

PloS one 20120101

Swim training reduces metformin levels in fructose-induced insulin resistant rats.

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20120101

Effect of the AMP-kinase modulators AICAR, metformin and compound C on insulin secretion of INS-1E rat insulinoma cells under standard cell culture conditions.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

Effects of some anti-diabetic and cardioprotective agents on proliferation and apoptosis of human coronary artery endothelial cells.

Cardiovascular diabetology 20120101

Podocyte as a potential target of inflammation: role of pioglitazone hydrochloride in patients with type 2 diabetes.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20120101

Metformin efficacy and safety for colorectal polyps: a double-blind randomized controlled trial.

BMC cancer 20120101

Cancer risk in diabetic patients treated with metformin: a systematic review and meta-analysis.

PloS one 20120101

Effectiveness of metformin and lifestyle interventions as an initial treatment in Japanese patients with newly diagnosed type 2 diabetes: a prospective observational study.

The journal of medical investigation : JMI 20120101

Effect of metformin and pioglitazone treatment on cardiovascular risk profile in polycystic ovary syndrome.

Acta medica Indonesiana 20120101

Metformin plus PIAF combination chemotherapy for hepatocellular carcinoma.

Experimental oncology 20120101

Metformin kills and radiosensitizes cancer cells and preferentially kills cancer stem cells.

Scientific reports 20120101

Is metformin indicated as primary ovulation induction agent in women with PCOS? A systematic review and meta-analysis.

Gynecologic and obstetric investigation 20120101

Mechanisms involved in the protective effects of metformin against nonalcoholic fatty liver disease.

Current medicinal chemistry 20120101

Metformin, an antidiabetic agent reduces growth of cutaneous squamous cell carcinoma by targeting mTOR signaling pathway.

Photochemistry and photobiology 20120101

Pancreatic β-cell dysfunction in polycystic ovary syndrome: the role of metformin.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20120101

[Molecular and genetic aspects of heart failure in diabetic patients].

Vestnik Rossiiskoi akademii meditsinskikh nauk 20120101

Hypoglycemics for the treatment of type 2 diabetes in patients with chronic kidney disease: a focus on new agents.

CANNT journal = Journal ACITN 20120101

Obesity and metformin.

Journal of pediatric endocrinology & metabolism : JPEM 20120101

Metformin use in children with obesity and normal glucose tolerance--effects on cardiovascular markers and intrahepatic fat.

Journal of pediatric endocrinology & metabolism : JPEM 20120101

The effects of metformin on inflammatory mediators in obese adolescents with insulin resistance: controlled randomized clinical trial.

Journal of pediatric endocrinology & metabolism : JPEM 20120101

Pharmacogenetics meets metabolomics: discovery of tryptophan as a new endogenous OCT2 substrate related to metformin disposition.

PloS one 20120101

[The influence of metformin and N-acetylcysteine on mammographic density in postmenopausal women].

Voprosy onkologii 20120101

[Drug therapy for diabetes mellitus during pregnancy and breastfeeding in the beginning of 21 century: status quo and new challenges].

Akusherstvo i ginekologiia 20120101

Ketosis-prone type 2 diabetes mellitus in a patient with Sheehan's syndrome: a rare convergence of two distinct endocrine entities.

BMJ case reports 20120101

Metformin rescues the myocardium from doxorubicin-induced energy starvation and mitochondrial damage in rats.

Oxidative medicine and cellular longevity 20120101

Effects of a vildagliptin/metformin combination on markers of atherosclerosis, thrombosis, and inflammation in diabetic patients with coronary artery disease.

Cardiovascular diabetology 20120101

Effect of metformin on hepatic glucose production in Japanese patients with type 2 diabetes mellitus.

Endocrine journal 20120101

Relation between augmentation index and adiponectin during one-year metformin treatment for nonalcoholic steatohepatosis: effects beyond glucose lowering?

Cardiovascular diabetology 20120101

Effects of exenatide vs. metformin on endothelial function in obese patients with pre-diabetes: a randomized trial.

Cardiovascular diabetology 20120101

The evaluation of risk factors associated with adverse drug reactions by metformin in type 2 diabetes mellitus.

Biological & pharmaceutical bulletin 20120101

The influence of type 2 diabetes and glucose-lowering therapies on cancer risk in the Taiwanese.

Experimental diabetes research 20120101

Cost-effectiveness and budget impact of saxagliptine as additional therapy to metformin for the treatment of diabetes mellitus type 2 in the Brazilian private health system.

Revista da Associacao Medica Brasileira (1992) 20120101

Comparison of metformin and insulin in the control of hyperglycaemia in non-diabetic critically ill patients.

Endokrynologia Polska 20120101

[Metformin does not suppress the aromatase expression in breast cancer tissue of patients with concurrent type 2 diabetes].

Voprosy onkologii 20120101

The metabolic syndrome, oxidative stress, environment, and cardiovascular disease: the great exploration.

Experimental diabetes research 20120101

Long-term clinical and economic outcomes associated with liraglutide versus sitagliptin therapy when added to metformin in the treatment of type 2 diabetes: a CORE Diabetes Model analysis.

Journal of medical economics 20120101

Initial combination therapy with metformin plus colesevelam improves lipoprotein particles in patients with early type 2 diabetes mellitus.

Journal of clinical lipidology 20120101

The role of PPARα in metformin-induced attenuation of mitochondrial dysfunction in acute cardiac ischemia/reperfusion in rats.

International journal of molecular sciences 20120101

[The influence of glucose on the free radical peroxidation of low density lipoproteins in vitro and in vivo].

Biomeditsinskaia khimiia 20120101

The glucose-deprivation network counteracts lapatinib-induced toxicity in resistant ErbB2-positive breast cancer cells.

Molecular systems biology 20120101

[Treatment of infertility].

Duodecim; laaketieteellinen aikakauskirja 20120101

Effects of genetic variants previously associated with fasting glucose and insulin in the Diabetes Prevention Program.

PloS one 20120101

Metformin inhibits growth of hepatocellular carcinoma cells by inducing apoptosis via mitochondrion-mediated pathway.

Asian Pacific journal of cancer prevention : APJCP 20120101

Fatal metformin intoxication with markedly elevated blood and liver concentrations.

Journal of analytical toxicology 20120101

Use of computer alerts to prevent the inappropriate use of metformin in an inpatient setting.

Quality management in health care 20120101

Genetics of type 2 diabetes mellitus and other specific types of diabetes; its role in treatment modalities.

Diabetes & metabolic syndrome 20120101

Glycemic control and weight changes in patients with type 2 diabetes intensified to three insulin regimens after therapeutic failure to exenatide.

Acta clinica Belgica 20120101

Metformin prevents and reverses inflammation in a non-diabetic mouse model of nonalcoholic steatohepatitis.

PloS one 20120101

Lovastatin induces multiple stress pathways including LKB1/AMPK activation that regulate its cytotoxic effects in squamous cell carcinoma cells.

PloS one 20120101

Renal podocyte injury in a rat model of type 2 diabetes is prevented by metformin.

Experimental diabetes research 20120101

Activation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in Drosophila.

PloS one 20120101

[Pharmacogenetic features of the effect of metformin in patients with coronary heart disease in the presence of metabolic syndrome and type 2 diabetes mellitus in terms of PPAR-gamma2 gene polymorphism].

Terapevticheskii arkhiv 20120101

[Role of metformin in diabetes treatment--is metformin falling from grace?].

Nederlands tijdschrift voor geneeskunde 20120101

Metformin stimulates FGF21 expression in primary hepatocytes.

Experimental diabetes research 20120101

Metformin reduces hepatic expression of SIRT3, the mitochondrial deacetylase controlling energy metabolism.

PloS one 20120101

5'-AMP-activated protein kinase (AMPK) regulates progesterone receptor transcriptional activity in breast cancer cells.

Biochemical and biophysical research communications 20111209

Antileukemic effects of AMPK activators on BCR-ABL-expressing cells.

Blood 20111208

Metformin regulates hepatic lipid metabolism through activating AMP-activated protein kinase and inducing ATGL in laying hens.

European journal of pharmacology 20111205

Controlling release of metformin HCl through incorporation into stomach specific floating alginate beads.

Molecular pharmaceutics 20111205

More favorable progesterone receptor phenotype of breast cancer in diabetics treated with metformin.

Medical oncology (Northwood, London, England) 20111201

Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1: predictions of metformin interactions.

The pharmacogenomics journal 20111201

Metformin-related lactic acidosis in patients with acute kidney injury.

International urology and nephrology 20111201

Thiazolidinediones and metformin associated with improved survival of diabetic prostate cancer patients.

Annals of oncology : official journal of the European Society for Medical Oncology 20111201

Metformin in prostate cancer: two for the price of one.

Annals of oncology : official journal of the European Society for Medical Oncology 20111201

The effects of rosiglitazone and metformin on inflammation and endothelial dysfunction in patients with type 2 diabetes mellitus.

Acta diabetologica 20111201

Dialysis therapy for lactic acidosis caused by metformin intoxication: presentation of two cases.

Human & experimental toxicology 20111201

Metformin as an antitumor agent in cancer prevention and treatment.

Journal of diabetes 20111201

Effects of combined exenatide and pioglitazone therapy on hepatic fat content in type 2 diabetes.

Obesity (Silver Spring, Md.) 20111201

Alogliptin as a third oral antidiabetic drug in patients with type 2 diabetes and inadequate glycaemic control on metformin and pioglitazone: a 52-week, randomized, double-blind, active-controlled, parallel-group study.

Diabetes, obesity & metabolism 20111201

Metformin opposes impaired AMPK and SIRT1 function and deleterious changes in core clock protein expression in white adipose tissue of genetically-obese db/db mice.

Diabetes, obesity & metabolism 20111201

Differences in insulin treatment satisfaction following randomized addition of biphasic, prandial or basal insulin to oral therapy in type 2 diabetes.

Diabetes, obesity & metabolism 20111201

The effects of metformin and letrozole on endometrium and ovary in a rat model.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20111201

Randomized study of repaglinide alone and in combination with metformin in Chinese subjects with type 2 diabetes naive to oral antidiabetes therapy.

Expert opinion on pharmacotherapy 20111201

Targeting the renin-angiotensin system: potential beneficial effects of the angiotensin II receptor blockers in patients with nonalcoholic steatohepatitis.

Hepatology (Baltimore, Md.) 20111201

Interleukin-6 as an early chronic inflammatory marker in polycystic ovary syndrome with insulin receptor substrate-2 polymorphism.

American journal of reproductive immunology (New York, N.Y. : 1989) 20111201

Reduced cell proliferation and neuroblast differentiation in the dentate gyrus of high fat diet-fed mice are ameliorated by metformin and glimepiride treatment.

Neurochemical research 20111201

Pioglitazone reduces urinary albumin excretion in renin-angiotensin system inhibitor-treated type 2 diabetic patients with hypertension and microalbuminuria: the APRIME study.

Clinical and experimental nephrology 20111201

Preactivation of AMPK by metformin may ameliorate the epithelial cell damage caused by renal ischemia.

American journal of physiology. Renal physiology 20111201

Bitter melon extracts in diabetic and normal rats favorably influence blood glucose and blood pressure regulation.

Journal of medicinal food 20111201

The cardioprotective effects of metformin.

Current opinion in lipidology 20111201

Chromatin occupancy of transcription factor 7-like 2 (TCF7L2) and its role in hepatic glucose metabolism.

Diabetologia 20111201

Sulfonylureas or dipeptidyl peptidase (DPP-4) inhibitors in the management of type 2 diabetes: debate is not yet closed.

Current diabetes reports 20111201

Adiponectin levels in nonalcoholic fatty liver disease.

Metabolism: clinical and experimental 20111201

Pharmacokinetics of a fixed-dose combination of atorvastatin and metformin extended release versus concurrent administration of individual formulations: a randomized, open-label, two-treatment, two-period, two-sequence, single-dose, crossover, bioequivalence study.

Clinical drug investigation 20111201

Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene.

Biochemical pharmacology 20111201

Serine racemase rs391300 G/A polymorphism influences the therapeutic efficacy of metformin in Chinese patients with diabetes mellitus type 2.

Clinical and experimental pharmacology & physiology 20111201

IGF1/insulin receptor kinase inhibition by BMS-536924 is better tolerated than alloxan-induced hypoinsulinemia and more effective than metformin in the treatment of experimental insulin-responsive breast cancer.

Endocrine-related cancer 20111201

Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status.

Diabetologia 20111201

Current perspectives of insulin resistance and polycystic ovary syndrome.

Diabetic medicine : a journal of the British Diabetic Association 20111201

Exenatide decreases hepatic fibroblast growth factor 21 resistance in non-alcoholic fatty liver disease in a mouse model of obesity and in a randomised controlled trial.

Diabetologia 20111201

Mechanisms underlying metformin-induced secretion of glucagon-like peptide-1 from the intestinal L cell.

Endocrinology 20111201

Protective role of antidiabetic drug metformin against gentamicin induced apoptosis in auditory cell line.

Hearing research 20111201

Metformin reduces risk of ovarian hyperstimulation syndrome in patients with polycystic ovary syndrome during gonadotropin-stimulated in vitro fertilization cycles: a randomized, controlled trial.

Fertility and sterility 20111201

The pharmacogenetics of metformin and its impact on plasma metformin steady-state levels and glycosylated hemoglobin A1c.

Pharmacogenetics and genomics 20111201

Dual inhibition of tumor energy pathway by 2-deoxyglucose and metformin is effective against a broad spectrum of preclinical cancer models.

Molecular cancer therapeutics 20111201

Linagliptin for the treatment of type 2 diabetes (pharmacokinetic evaluation).

Expert opinion on drug metabolism & toxicology 20111201

Comparisons of persistence and durability among three oral antidiabetic therapies using electronic prescription-fill data: the impact of adherence requirements and stockpiling.

Clinical pharmacology and therapeutics 20111201

Effects of acarbose versus glibenclamide on glycemic excursion and oxidative stress in type 2 diabetic patients inadequately controlled by metformin: a 24-week, randomized, open-label, parallel-group comparison.

Clinical therapeutics 20111201

Drug treatment of obesity.

The Psychiatric clinics of North America 20111201

Progression to insulin for patients with diabetes mellitus using the Texas Medicaid database.

Clinical therapeutics 20111201

Current world literature.

Current opinion in lipidology 20111201

Monitoring metformin in cardiac patients exposed to contrast media using ultra-high-performance liquid chromatography tandem mass-spectrometry.

Therapeutic drug monitoring 20111201

Pregnancy management of women with pregestational diabetes.

Endocrinology and metabolism clinics of North America 20111201

Beyond metformin: initiating combination therapy in patients with type 2 diabetes mellitus.

Pharmacotherapy 20111201

Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue.

Cell cycle (Georgetown, Tex.) 20111201

[Metformin and insulin in chronic heart failure: contraindications not contraindicated and indications not indicated].

Giornale italiano di cardiologia (2006) 20111201

A novel cardioprotective agent in cardiac transplantation: metformin activation of AMP-activated protein kinase decreases acute ischemia-reperfusion injury and chronic rejection.

The Yale journal of biology and medicine 20111201

AICAR, a small chemical molecule, primes osteogenic differentiation of adult mesenchymal stem cells.

The International journal of artificial organs 20111201

Metformin: multi-faceted protection against cancer.

Oncotarget 20111201

Diabetes, cancer, and metformin: connections of metabolism and cell proliferation.

Annals of the New York Academy of Sciences 20111201

Economic evaluation of outpatients with type 2 diabetes mellitus assisted by a pharmaceutical care service.

Arquivos brasileiros de endocrinologia e metabologia 20111201

AMPK in BCR-ABL expressing leukemias. Regulatory effects and therapeutic implications.

Oncotarget 20111201

Metformin as an adjunct to insulin for glycemic control in patients with type 2 diabetes after CABG surgery: a randomized double blind clinical trial.

Pakistan journal of biological sciences : PJBS 20111201

[Incretin-based therapy for treating patients with type 2 diabetes].

Orvosi hetilap 20111127

Prognostic influence of metformin as first-line chemotherapy for advanced nonsmall cell lung cancer in patients with type 2 diabetes.

Cancer 20111115

Metformin protects against doxorubicin-induced cardiotoxicity: involvement of the adiponectin cardiac system.

Free radical biology & medicine 20111115

Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells.

Cancer biology & therapy 20111115

Cost-effectiveness of second-line antihyperglycemic therapy in patients with type 2 diabetes mellitus inadequately controlled on metformin.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20111108

Relevance of the OCT1 transporter to the antineoplastic effect of biguanides.

Biochemical and biophysical research communications 20111104

Insulin resistance and liver microcirculation in a rat model of early NAFLD.

Journal of hepatology 20111101

Can the therapeutic effects of temozolomide be potentiated by stimulating AMP-activated protein kinase with olanzepine and metformin?

British journal of pharmacology 20111101

Fatty acid-binding protein-4 plasma levels are associated to metabolic abnormalities and response to therapy in girls and young women with androgen excess.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20111101

A randomized, parallel group, double-blind, multicentre study comparing the efficacy and safety of Avandamet (rosiglitazone/metformin) and metformin on long-term glycaemic control and bone mineral density after 80 weeks of treatment in drug-naïve type 2 diabetes mellitus patients.

Diabetes, obesity & metabolism 20111101

Rosiglitazone versus rosiglitazone and metformin versus rosiglitazone and losartan in the treatment of nonalcoholic steatohepatitis in humans: a 12-month randomized, prospective, open- label trial.

Hepatology (Baltimore, Md.) 20111101

Exendin-4 upregulates the expression of Wnt-4, a novel regulator of pancreatic β-cell proliferation.

American journal of physiology. Endocrinology and metabolism 20111101

Efficacy and safety of linagliptin in persons with type 2 diabetes inadequately controlled by a combination of metformin and sulphonylurea: a 24-week randomized study.

Diabetic medicine : a journal of the British Diabetic Association 20111101

Use of metformin and the risk of ovarian cancer: a case-control analysis.

Gynecologic oncology 20111101

Elevated circulating vaspin levels were decreased by rosiglitazone therapy in T2DM patients with poor glycemic control on metformin alone.

Cytokine 20111101

Clinical, endocrine and metabolic effects of metformin vs N-acetyl-cysteine in women with polycystic ovary syndrome.

European journal of obstetrics, gynecology, and reproductive biology 20111101

Effects of short-term therapy with glibenclamide and repaglinide on incretin hormones and oxidative damage associated with postprandial hyperglycaemia in people with type 2 diabetes mellitus.

Diabetes research and clinical practice 20111101

Associations between the use of metformin, sulphonylureas, or diet alone and cardiovascular outcomes in 6005 people with type 2 diabetes in the FIELD study.

Diabetes research and clinical practice 20111101

Effects of simvastatin and metformin on polycystic ovary syndrome after six months of treatment.

The Journal of clinical endocrinology and metabolism 20111101

Treatment of androgen excess in adolescent girls: ethinylestradiol-cyproteroneacetate versus low-dose pioglitazone-flutamide-metformin.

The Journal of clinical endocrinology and metabolism 20111101

Efficacy and safety of saxagliptin added to metformin in Asian people with type 2 diabetes mellitus: a randomized controlled trial.

Diabetes research and clinical practice 20111101

Inhibition of hepatitis C virus replication through adenosine monophosphate-activated protein kinase-dependent and -independent pathways.

Microbiology and immunology 20111101

Weight beneficial treatments for type 2 diabetes.

The Journal of clinical endocrinology and metabolism 20111101

Linking biological activity with herbal constituents by systems biology-based approaches: effects of Panax ginseng in type 2 diabetic Goto-Kakizaki rats.

Molecular bioSystems 20111101

Does metformin affect the ovarian response to gonadotropins for in vitro fertilization treatment in patients with polycystic ovary syndrome and reduced ovarian reserve? A randomized controlled trial.

Fertility and sterility 20111101

Insulin sensitizers may attenuate lean mass loss in older men with diabetes.

Diabetes care 20111101

Should combination therapy be the paradigm for future nonalcoholic steatohepatitis clinical trials?

Hepatology (Baltimore, Md.) 20111101

A common 5'-UTR variant in MATE2-K is associated with poor response to metformin.

Clinical pharmacology and therapeutics 20111101

[Slow the pace of renal failure in autosomal dominant polycystic kidney disease: hopes and disappointments].

Presse medicale (Paris, France : 1983) 20111101

Pharmacokinetics of metformin in girls aged 9 years.

Clinical pharmacokinetics 20111101

Pharmacokinetic comparison of a new sustained-release formulation of glimepiride/metformin 1/500 mg combination tablet and a sustained-release formulation of glimepiride/metformin 2/500 mg combination tablet in healthy Korean male volunteers: a randomized, 2-sequence, 2-period, 2-treatment crossover study.

Clinical therapeutics 20111101

Characterizing the structure of pharmaceutical granules obtained by wet granulation with varying amounts of water via Raman chemical imaging.

Applied spectroscopy 20111101

Insulin sensitisers in the treatment of non-alcoholic fatty liver disease: a systematic review.

Health technology assessment (Winchester, England) 20111101

Pioglitazone may accelerate disease course of slowly progressive type 1 diabetes.

Diabetes/metabolism research and reviews 20111101

Metabolic correction in the management of diabetic peripheral neuropathy: improving clinical results beyond symptom control.

Current clinical pharmacology 20111101

Metformin and the ATM DNA damage response (DDR): accelerating the onset of stress-induced senescence to boost protection against cancer.

Aging 20111101

Prevalence of diabetic retinopathy in Peruvian patients with type 2 diabetes: results of a hospital-based retinal telescreening program.

Revista panamericana de salud publica = Pan American journal of public health 20111101

Lactic acidosis, hypotension, and sensorineural hearing loss following intentional metformin overdose.

Current drug safety 20111101

Therapeutic effect of metformin and vitamin E versus prescriptive diet in obese adolescents with fatty liver.

International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 20111101

Combination of TS-021 with metformin improves hyperglycemia and synergistically increases pancreatic β-cell mass in a mouse model of type 2 diabetes.

Life sciences 20111024

[Hypoglycemia].

Praxis 20111019

In vitro and in vivo anti-melanoma action of metformin.

European journal of pharmacology 20111015

Metformin prevents anti-osteogenic in vivo and ex vivo effects of rosiglitazone in rats.

European journal of pharmacology 20111015

Effect of aqueous extract of the leaves of Acalypha wilkesiana 'Godseffiana' Muell Arg (Euphorbiaceae) on the hematology, plasma biochemistry and ocular indices of oxidative stress in alloxan induced diabetic rats.

Journal of ethnopharmacology 20111011

Hypoglycaemic activity and molecular mechanisms of Caesalpinia ferrea Martius bark extract on streptozotocin-induced diabetes in Wistar rats.

Journal of ethnopharmacology 20111011

Statins for women with polycystic ovary syndrome not actively trying to conceive.

The Cochrane database of systematic reviews 20111005

Intensive glucose control and cardiovascular outcomes in type 2 diabetes.

Heart, lung & circulation 20111001

Type 2 diabetes mellitus and medications for type 2 diabetes mellitus are associated with risk for and mortality from cancer in a German primary care cohort.

Metabolism: clinical and experimental 20111001

Can metformin reduce the incidence of gestational diabetes mellitus in pregnant women with polycystic ovary syndrome? Prospective cohort study.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20111001

Metformin counters both lipolytic/inflammatory agents-decreased hormone sensitive lipase phosphorylation at Ser-554 and -induced lipolysis in human adipocytes.

Archives of physiology and biochemistry 20111001

A systematic review of metformin to limit weight-gain with atypical antipsychotics.

Journal of clinical pharmacy and therapeutics 20111001

Inlay osmotic pump tablets containing metformin and glipizide.

Drug development and industrial pharmacy 20111001

Metformin pharmacokinetics in nondiabetic pregnant women with polycystic ovary syndrome.

European journal of clinical pharmacology 20111001

Pectin from Passiflora edulis shows anti-inflammatory action as well as hypoglycemic and hypotriglyceridemic properties in diabetic rats.

Journal of medicinal food 20111001

Long-term metformin treatment is able to reduce the prevalence of metabolic syndrome and its hepatic involvement in young hyperinsulinaemic overweight patients with polycystic ovarian syndrome.

Clinical endocrinology 20111001

Metformin stimulates osteoprotegerin and reduces RANKL expression in osteoblasts and ovariectomized rats.

Journal of cellular biochemistry 20111001

Does metformin influence the insulin-, IGF I- and IGF II-receptor gene expression and Akt phosphorylation in human decidualized endometrial stromal cells?

European journal of obstetrics, gynecology, and reproductive biology 20111001

Organic cation transporter 3: expression in failing and nonfailing human heart and functional characterization.

Journal of cardiovascular pharmacology 20111001

Activated AMPK inhibits PPAR-{alpha} and PPAR-{gamma} transcriptional activity in hepatoma cells.

American journal of physiology. Gastrointestinal and liver physiology 20111001

Incomplete aerobic degradation of the antidiabetic drug Metformin and identification of the bacterial dead-end transformation product Guanylurea.

Chemosphere 20111001

Association of the SLC30A8 missense polymorphism R325W with proinsulin levels at baseline and after lifestyle, metformin or troglitazone intervention in the Diabetes Prevention Program.

Diabetologia 20111001

Hypoglycemic effects and constituents of the barks of Cyclocarya paliurus and their inhibiting activities to glucosidase and glycogen phosphorylase.

Fitoterapia 20111001

The role of metformin and thiazolidinediones in the regulation of hepatic glucose metabolism and its clinical impact.

Trends in pharmacological sciences 20111001

Metformin and/or clomiphene do not adversely affect liver or renal function in women with polycystic ovary syndrome.

The Journal of clinical endocrinology and metabolism 20111001

APPL1 mediates adiponectin-induced LKB1 cytosolic localization through the PP2A-PKCzeta signaling pathway.

Molecular endocrinology (Baltimore, Md.) 20111001

GLUT2 accumulation in enterocyte apical and intracellular membranes: a study in morbidly obese human subjects and ob/ob and high fat-fed mice.

Diabetes 20111001

mTORC1 activity as a determinant of cancer risk--rationalizing the cancer-preventive effects of adiponectin, metformin, rapamycin, and low-protein vegan diets.

Medical hypotheses 20111001

Metformin as a geroprotector.

Rejuvenation research 20111001

Retrospective chart review of children with type 2 diabetes mellitus evaluating the efficacy of metformin vs. insulin vs. combination insulin/metformin.

Southern medical journal 20111001

Metformin in gestational diabetes: the offspring follow-up (MiG TOFU): body composition at 2 years of age.

Diabetes care 20111001

Reduced risk of colorectal cancer with metformin therapy in patients with type 2 diabetes: a meta-analysis.

Diabetes care 20111001

Metformin therapy during pregnancy: good for the goose and good for the gosling too?

Diabetes care 20111001

Metformin and colorectal cancer risk in diabetic patients.

Diabetes care 20111001

Garlic (Allium sativum) supplementation with standard antidiabetic agent provides better diabetic control in type 2 diabetes patients.

Pakistan journal of pharmaceutical sciences 20111001

[Pancreatic diseases: update 2011].

Deutsche medizinische Wochenschrift (1946) 20111001

Bioequivalence assessment of metformin hydrochloride using a limited sampling strategy.

International journal of clinical pharmacology and therapeutics 20111001

Norepinephrine uptake mechanisms in cardiovascular disease deserve our attention.

Journal of cardiovascular pharmacology 20111001

Fixed dose combination diabetes medicines - usage in the Australian veteran population.

Australian family physician 20111001

[Rare cause of insufficient metabolic control of diabetes mellitus - Case 10/2011].

Deutsche medizinische Wochenschrift (1946) 20111001

Obesity and insulin resistance in breast cancer--chemoprevention strategies with a focus on metformin.

Breast (Edinburgh, Scotland) 20111001

Genome protective effect of metformin as revealed by reduced level of constitutive DNA damage signaling.

Aging 20111001

Metformin intoxication requiring dialysis.

Hemodialysis international. International Symposium on Home Hemodialysis 20111001

Metformin hydrochloride-loaded poly(vinyl alcohol) composites as drug delivery systems.

Journal of nanoscience and nanotechnology 20111001

Interaction of cinnamic acid derivatives with commercial hypoglycemic drugs on 2-deoxyglucose uptake in 3T3-L1 adipocytes.

Journal of agricultural and food chemistry 20110928

[Dipeptidyl-peptidase-4 inhibitors (gliptins): a new class of oral antidiabetic drugs].

Orvosi hetilap 20110911

Interventions for latent autoimmune diabetes (LADA) in adults.

The Cochrane database of systematic reviews 20110907

Pressure-independent cerebrovascular remodelling and changes in myogenic reactivity in diabetic Goto-Kakizaki rat in response to glycaemic control.

Acta physiologica (Oxford, England) 20110901

Inflammatory-metabolic parameters in obese and nonobese normoandrogenemic polycystic ovary syndrome during metformin and oral contraceptive treatment.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20110901

Metformin promotes progesterone receptor expression via inhibition of mammalian target of rapamycin (mTOR) in endometrial cancer cells.

The Journal of steroid biochemistry and molecular biology 20110901

Use of metformin in pediatric age.

Pediatric diabetes 20110901

Treatment with insulin sensitizer metformin improves arterial properties, metabolic parameters, and liver function in patients with nonalcoholic fatty liver disease: a randomized, placebo-controlled trial.

Metabolism: clinical and experimental 20110901

Triple oral fixed-dose diabetes polypill versus insulin plus metformin efficacy demonstration study in the treatment of advanced type 2 diabetes (TrIED study-II).

Diabetes, obesity & metabolism 20110901

An analysis of early insulin glargine added to metformin with or without sulfonylurea: impact on glycaemic control and hypoglycaemia.

Diabetes, obesity & metabolism 20110901

Randomized controlled trial of different doses of metformin for ovulation induction in infertile women with polycystic ovary syndrome.

The journal of obstetrics and gynaecology research 20110901

Thyroidal effect of metformin treatment in patients with polycystic ovary syndrome.

Clinical endocrinology 20110901

Thyrotropin-lowering effect of metformin in a patient with resistance to thyroid hormone.

Clinical endocrinology 20110901

A treatment strategy implementing combination therapy with sitagliptin and metformin results in superior glycaemic control versus metformin monotherapy due to a low rate of addition of antihyperglycaemic agents.

Diabetes, obesity & metabolism 20110901

Prognostic value of total testosterone for pregnancy during treatment in patients with clomiphene-citrate-resistant polycystic ovary syndrome: a pilot study.

Archives of gynecology and obstetrics 20110901

Multifactorial intervention in individuals with type 2 diabetes and microalbuminuria: the Microalbuminuria Education and Medication Optimisation (MEMO) study.

Diabetes research and clinical practice 20110901

Exenatide or glimepiride added to metformin on metabolic control and on insulin resistance in type 2 diabetic patients.

European journal of pharmacology 20110901

Characterization of the inhibitory effects of N-butylpyridinium chloride and structurally related ionic liquids on organic cation transporters 1/2 and human toxic extrusion transporters 1/2-k in vitro and in vivo.

Drug metabolism and disposition: the biological fate of chemicals 20110901

Metformin for gestational diabetes in routine clinical practice.

Diabetic medicine : a journal of the British Diabetic Association 20110901

Therapeutic effects of metformin in breast cancer: involvement of the immune system?

Cancer immunology, immunotherapy : CII 20110901

Effects of Portulaca oleracea L. seeds in treatment of type-2 diabetes mellitus patients as adjunctive and alternative therapy.

Journal of ethnopharmacology 20110901

Uptake and translocation of metformin, ciprofloxacin and narasin in forage- and crop plants.

Chemosphere 20110901

Could there be a role for metformin in type 1 and type 2 diabetic pregnancies?

Diabetologia 20110901

AMP-activated protein kinase: also regulated by ADP?

Trends in biochemical sciences 20110901

Vildagliptin improves endothelium-dependent vasodilatation in type 2 diabetes.

Diabetes care 20110901

A case of lactic acidosis (LA) after administration of tenofovir and metformin in a diabetic patient with recently diagnosed HIV infection.

Journal of renal care 20110901

Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: a randomized, 52-week, double-blind, active-controlled noninferiority trial.

Diabetes care 20110901

Adherence to oral antidiabetic agents with pioglitazone and metformin: comparison of fixed-dose combination therapy with monotherapy and loose-dose combination therapy.

Clinical therapeutics 20110901

Efficacy and safety of sitagliptin and the fixed-dose combination of sitagliptin and metformin vs. pioglitazone in drug-naïve patients with type 2 diabetes.

International journal of clinical practice 20110901

Potent anti-proliferative effects of metformin on trastuzumab-resistant breast cancer cells via inhibition of erbB2/IGF-1 receptor interactions.

Cell cycle (Georgetown, Tex.) 20110901

Effects of exenatide on measures of β-cell function after 3 years in metformin-treated patients with type 2 diabetes.

Diabetes care 20110901

Incretin-based therapy and the quest for sustained improvements in β-cell health.

Diabetes care 20110901

Liver uptake of biguanides in rats.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20110901

Metformin inhibits melanoma development through autophagy and apoptosis mechanisms.

Cell death & disease 20110901

Efficacy of Chinese patent medicine Tian Gui Capsule in patients with polycystic ovary syndrome: a randomized controlled trial.

Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20110901

Intensifying type 2 diabetes therapy: assessing the options. Introduction.

The Journal of family practice 20110901

Options for intensifying diabetes treatment.

The Journal of family practice 20110901

Activation of imidazoline I-2B receptor by metformin to increase glucose uptake in skeletal muscle.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20110901

Anti-Müllerian hormone in women with polycystic ovary syndrome before and after therapy with metformin.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20110901

[Effect of metformin on apoptosis of renal cell carcinoma cells in vitro and its mechanisms].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20110901

Diabetes mellitus and the risk of cancer.

Minerva endocrinologica 20110901

Hypoglycemic effects and biochemical mechanisms of oat products on streptozotocin-induced diabetic mice.

Journal of agricultural and food chemistry 20110824

Metformin abolishes increased tumor (18)F-2-fluoro-2-deoxy-D-glucose uptake associated with a high energy diet.

Cell cycle (Georgetown, Tex.) 20110815

Profibrinolytic, antithrombotic, and antiinflammatory effects of an insulin-sensitizing strategy in patients in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial.

Circulation 20110809

Glycated hemoglobin as a prognostic risk marker in nondiabetic patients after acute myocardial infarction: what now?

Circulation 20110809

Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control.

Cell metabolism 20110803

The impact of oral contraceptives and metformin on anti-Müllerian hormone serum levels in women with polycystic ovary syndrome and biochemical hyperandrogenemia.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20110801

AMPK and vasculoprotection.

Pharmacology & therapeutics 20110801

Influence of CYP2C9 gene polymorphisms on response to glibenclamide in type 2 diabetes mellitus patients.

European journal of clinical pharmacology 20110801

Treatment intensification in patients with type 2 diabetes who failed metformin monotherapy.

Diabetes, obesity & metabolism 20110801

Mortality and cardiovascular risk associated with different insulin secretagogues compared with metformin in type 2 diabetes, with or without a previous myocardial infarction: a nationwide study.

European heart journal 20110801

Resolving drug effects from class effects among drugs for type 2 diabetes mellitus: more support for cardiovascular outcome assessments.

European heart journal 20110801

Influence of LH and high-density lipoprotein cholesterol (HDL-C) on metformin response in women with polycystic ovary syndrome.

European journal of obstetrics, gynecology, and reproductive biology 20110801

The complete control of glucose level utilizing the composition of ketogenic diet with the gluconeogenesis inhibitor, the anti-diabetic drug metformin, as a potential anti-cancer therapy.

Medical hypotheses 20110801

Metformin improves cardiac function in a nondiabetic rat model of post-MI heart failure.

American journal of physiology. Heart and circulatory physiology 20110801

Do women with ovaries of polycystic morphology without any other features of PCOS benefit from short-term metformin co-treatment during IVF? A double-blind, placebo-controlled, randomized trial.

Human reproduction (Oxford, England) 20110801

Use of metformin before and during assisted reproductive technology in non-obese young infertile women with polycystic ovary syndrome: a prospective, randomized, double-blind, multi-centre study.

Human reproduction (Oxford, England) 20110801

Metformin as adjuvant therapy to IVF in women with PCOS: when is intention-to-treat unintentional?

Human reproduction (Oxford, England) 20110801

Mice lacking TR4 nuclear receptor develop mitochondrial myopathy with deficiency in complex I.

Molecular endocrinology (Baltimore, Md.) 20110801

AMP-activated protein kinase: a potential player in Alzheimer's disease.

Journal of neurochemistry 20110801

Early metformin therapy (age 8-12 years) in girls with precocious pubarche to reduce hirsutism, androgen excess, and oligomenorrhea in adolescence.

The Journal of clinical endocrinology and metabolism 20110801

Effect of concomitant statin, metformin, or aspirin on rituximab treatment for diffuse large B-cell lymphoma.

Leukemia & lymphoma 20110801

Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial.

Breast cancer research and treatment 20110801

Impact of rosiglitazone therapy on the lipid profile, glycemic control, and medication costs among type 2 diabetes patients.

Current medical research and opinion 20110801

Menopause and risk of diabetes in the Diabetes Prevention Program.

Menopause (New York, N.Y.) 20110801

Lifestyle intervention in postmenopausal women: winning the game against diabetes.

Menopause (New York, N.Y.) 20110801

Metformin induces G1 cell cycle arrest and inhibits cell proliferation in nasopharyngeal carcinoma cells.

Anatomical record (Hoboken, N.J. : 2007) 20110801

Weight-reducing effects of metformin are sustained over 40 weeks for psychiatric inpatients receiving polypharmacy.

Journal of clinical psychopharmacology 20110801

Effect of combined metformin and oral contraceptive therapy on metabolic factors and endothelial function in overweight and obese women with polycystic ovary syndrome.

Fertility and sterility 20110801

Impact of metformin on the prognosis of cirrhosis induced by viral hepatitis C in diabetic patients.

The Journal of clinical endocrinology and metabolism 20110801

Impact of insulin-sensitizing agents on risk for liver cancer and liver-related death in diabetic patients with compensated hepatitis C cirrhosis.

The Journal of clinical endocrinology and metabolism 20110801

Glucolipotoxicity and beta cells in type 2 diabetes mellitus: target for durable therapy?

Diabetes research and clinical practice 20110801

Metabolic syndrome and mental illness. Weight gain and other unhealthy attributes increase risk of diabetes and heart disease.

The Harvard mental health letter 20110801

[Diabetes and cancer risk: oncologic considerations].

Orvosi hetilap 20110717

Metformin attenuates streptozotocin-induced diabetic nephropathy in rats through modulation of oxidative stress genes expression.

Chemico-biological interactions 20110715

A convenient synthesis of novel pyranosyl homo-C-nucleosides and their antidiabetic activities.

Carbohydrate research 20110715

Liquid chromatographic determination of sitagliptin either alone or in ternary mixture with metformin and sitagliptin degradation product.

Talanta 20110715

Insulin management of type 2 diabetes mellitus.

American family physician 20110715

Nonalcoholic fatty liver disease: Targeted therapy in children--what is the right way?

Nature reviews. Gastroenterology & hepatology 20110712

Influence of therapy with metformin on the concentration of certain divalent cations in patients with non-insulin-dependent diabetes mellitus.

Biological trace element research 20110701

Isolated and combined action of tamoxifen and metformin in wild-type, tamoxifen-resistant, and estrogen-deprived MCF-7 cells.

Breast cancer research and treatment 20110701

Anti-inflammatory effects of thiazolidinediones in human airway smooth muscle cells.

American journal of respiratory cell and molecular biology 20110701

Activated AMPK and prostaglandins are involved in the response to conjugated linoleic acid and are sufficient to cause lipid reductions in adipocytes.

The Journal of nutritional biochemistry 20110701

Adipose triglyceride lipase expression in human adipose tissue and muscle. Role in insulin resistance and response to training and pioglitazone.

Metabolism: clinical and experimental 20110701

Effect of metformin on oxidative stress, nitrosative stress and inflammatory biomarkers in type 2 diabetes patients.

Diabetes research and clinical practice 20110701

Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats.

Clinical science (London, England : 1979) 20110701

Saxagliptin, a potent, selective inhibitor of DPP-4, does not alter the pharmacokinetics of three oral antidiabetic drugs (metformin, glyburide or pioglitazone) in healthy subjects.

Diabetes, obesity & metabolism 20110701

The effect of initial therapy with the fixed-dose combination of sitagliptin and metformin compared with metformin monotherapy in patients with type 2 diabetes mellitus.

Diabetes, obesity & metabolism 20110701

Promoter-specific effects of metformin on aromatase transcript expression.

Steroids 20110701

AMP-activated protein kinase is activated in adipose tissue of individuals with type 2 diabetes treated with metformin: a randomised glycaemia-controlled crossover study.

Diabetologia 20110701

A Dose-Ranging Study of the DPP-IV Inhibitor PF-734200 Added to Metformin in Subjects With Type 2 Diabetes*.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20110701

Sitagliptin more effectively achieves a composite endpoint for A1C reduction, lack of hypoglycemia and no body weight gain compared with glipizide.

Diabetes research and clinical practice 20110701

The effects of metformin or orlistat on obese women with polycystic ovary syndrome: a prospective randomized open-label study.

Journal of assisted reproduction and genetics 20110701

Intensive glucose control and risk of cancer in patients with type 2 diabetes.

Diabetologia 20110701

The administration of metformin during pregnancy reduces polycystic ovary syndrome related gestational complications.

European journal of obstetrics, gynecology, and reproductive biology 20110701

Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1.

Cancer research 20110701

Metformin attenuates pressure overload-induced cardiac hypertrophy via AMPK activation.

Acta pharmacologica Sinica 20110701

Should metformin be our antiglycemic agent of choice post-transplantation?

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20110701

Mechanisms for membrane transport of metformin in human intestinal epithelial Caco-2 cells.

Biopharmaceutics & drug disposition 20110701

Comparison of the dipeptidyl peptidase-4 inhibitor vildagliptin and the sulphonylurea gliclazide in combination with metformin, in Muslim patients with type 2 diabetes mellitus fasting during Ramadan: results of the VECTOR study.

Current medical research and opinion 20110701

LKB1/AMPK/mTOR signaling pathway in hematological malignancies: from metabolism to cancer cell biology.

Cell cycle (Georgetown, Tex.) 20110701

Responsiveness to metformin in girls with androgen excess: collective influence of genetic polymorphisms.

Fertility and sterility 20110701

Clinical practice and implications of recent diabetes trials.

Current opinion in cardiology 20110701

Metformin and exercise in type 2 diabetes: examining treatment modality interactions.

Diabetes care 20110701

Suppression of FoxO1 activity by long-chain fatty acyl analogs.

Diabetes 20110701

Trends in drug prescriptions to diabetic patients from 2000 to 2008 in Italy's Lombardy Region: a large population-based study.

Diabetes research and clinical practice 20110701

Efficacy and safety of saxagliptin combination therapy in US patients with type 2 diabetes.

Postgraduate medicine 20110701

Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells.

Cancer 20110701

Changes over time in glycemic control, insulin sensitivity, and beta-cell function in response to low-dose metformin and thiazolidinedione combination therapy in patients with impaired glucose tolerance.

Diabetes care 20110701

What's next for diabetes prevention?

Diabetes care 20110701

Adherence to medication under mandatory and voluntary mail benefit designs.

The American journal of managed care 20110701

Metformin-induced hemolytic anemia.

The Israel Medical Association journal : IMAJ 20110701

More adverse neurological consequences of metformin-induced vitamin B12 deficiency.

Southern medical journal 20110701

Melatonin and metformin inhibit skin carcinogenesis and lipid peroxidation induced by benz(a)pyrene in female mice.

Bulletin of experimental biology and medicine 20110701

Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice.

Fertility and sterility 20110630

Insulin resistance influences central opioid activity in polycystic ovary syndrome.

Fertility and sterility 20110630

Effects of metformin in adolescents with polycystic ovary syndrome undertaking lifestyle therapy: a pilot randomized double-blind study.

Fertility and sterility 20110630

Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes.

Behavioural brain research 20110620

AMPK induces MUC5B expression via p38 MAPK in NCI-H292 airway epithelial cells.

Biochemical and biophysical research communications 20110617

Metformin amplifies chemotherapy-induced AMPK activation and antitumoral growth.

Clinical cancer research : an official journal of the American Association for Cancer Research 20110615

Levels of evidence needed for changing indications, contraindications, and Food and Drug Administration labeling: the case of metformin.

Archives of internal medicine 20110613

Inhibition of the Unfolded Protein Response by metformin in renal proximal tubular epithelial cells.

Biochemical and biophysical research communications 20110610

Baicalin upregulates the genetic expression of antioxidant enzymes in Type-2 diabetic Goto-Kakizaki rats.

Life sciences 20110606

AMP-activated protein kinase attenuates Wnt/β-catenin signaling in human osteoblastic Saos-2 cells.

Molecular and cellular endocrinology 20110606

Metformin-associated lactic acidosis treated with prolonged hemodialysis.

The American journal of emergency medicine 20110601

The anti-atherogenic aspect of metformin treatment in insulin resistant women with the polycystic ovary syndrome: role of the newly established pro-inflammatory adipokine Acute-phase Serum Amyloid A; evidence of an adipose tissue-monocyte axis.

Atherosclerosis 20110601

Double-transfected MDCK cells expressing human OCT1/MATE1 or OCT2/MATE1: determinants of uptake and transcellular translocation of organic cations.

British journal of pharmacology 20110601

Impaired renal function modifies the risk of severe hypoglycaemia among users of insulin but not glyburide: a population-based nested case-control study.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20110601

Metformin should be considered in the treatment of gestational diabetes: a prospective randomised study.

BJOG : an international journal of obstetrics and gynaecology 20110601

Metformin for obesity and glucose dysregulation in patients with schizophrenia receiving antipsychotic drugs.

Journal of psychopharmacology (Oxford, England) 20110601

Initial combination therapy with saxagliptin and metformin provides sustained glycaemic control and is well tolerated for up to 76 weeks.

Diabetes, obesity & metabolism 20110601

Prognostic implications of glucose-lowering treatment in patients with acute myocardial infarction and diabetes: experiences from an extended follow-up of the Diabetes Mellitus Insulin-Glucose Infusion in Acute Myocardial Infarction (DIGAMI) 2 Study.

Diabetologia 20110601

Impact of a glycogen phosphorylase inhibitor and metformin on basal and glucagon-stimulated hepatic glucose flux in conscious dogs.

The Journal of pharmacology and experimental therapeutics 20110601

Early onset and high prevalence of gestational diabetes in PCOS and insulin resistant women before and after assisted reproduction.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20110601

Do placebo based validation standards mimic real batch products behaviour? Case studies.

Journal of pharmaceutical and biomedical analysis 20110601

Liraglutide therapy in Prader-Willi syndrome.

Diabetic medicine : a journal of the British Diabetic Association 20110601

Induction of apoptosis by metformin in epithelial ovarian cancer: involvement of the Bcl-2 family proteins.

Gynecologic oncology 20110601

Oral exposure to drugs with immune-adjuvant potential induces hypersensitivity responses to the reporter antigen TNP-OVA.

Toxicological sciences : an official journal of the Society of Toxicology 20110601

Nonalcoholic fatty liver disease and type 2 diabetes mellitus: the hidden epidemic.

The American journal of the medical sciences 20110601

Scintigraphic diagnosis of Erdheim-Chester disease.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110601

DURATION-2: efficacy and safety of switching from maximum daily sitagliptin or pioglitazone to once-weekly exenatide.

Diabetic medicine : a journal of the British Diabetic Association 20110601

Simultaneous quantitation of metformin and sitagliptin from mouse and human dried blood spots using laser diode thermal desorption tandem mass spectrometry.

Journal of pharmaceutical and biomedical analysis 20110601

In search of the 'LINK': Acute Phase Serum Amyloid A.

Atherosclerosis 20110601

PIOfix-study: effects of pioglitazone/metformin fixed combination in comparison with a combination of metformin with glimepiride on diabetic dyslipidemia.

Diabetes technology & therapeutics 20110601

Acute kidney injury associated with metformin.

The American journal of emergency medicine 20110601

Investigation of the potential effects of metformin on atherothrombotic risk factors in hyperlipidemic rats.

European journal of pharmacology 20110601

Effects of metformin and pioglitazone on serum pentosidine levels in type 2 diabetes mellitus.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20110601

Effect of gastric bypass surgery on the absorption and bioavailability of metformin.

Diabetes care 20110601

Ovarian drilling for surgical treatment of polycystic ovarian syndrome: a comprehensive review.

Reproductive biomedicine online 20110601

Effects of a MATE protein inhibitor, pyrimethamine, on the renal elimination of metformin at oral microdose and at therapeutic dose in healthy subjects.

Clinical pharmacology and therapeutics 20110601

Metformin associated lactic acidosis: incidence and clinical correlation with metformin serum concentration measurements.

Journal of clinical pharmacy and therapeutics 20110601

Increased F-18 FDG intestinal uptake in diabetic patients on metformin: a matched case-control analysis.

Clinical nuclear medicine 20110601

Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice.

Diabetes 20110601

Management of metabolic syndrome in children and adolescents.

Nutrition, metabolism, and cardiovascular diseases : NMCD 20110601

Oral hypoglycemic agents in pregnancy.

Obstetrics and gynecology clinics of North America 20110601

Quiz page June 2011. Profound metabolic acidosis and abdominal pain in a diabetic patient on long-term hemodialysis.

American journal of kidney diseases : the official journal of the National Kidney Foundation 20110601

Use of metformin in the setting of mild-to-moderate renal insufficiency.

Diabetes care 20110601

What, how, and how much should patients with burns be fed?

The Surgical clinics of North America 20110601

Analysis of factors predicting success of metformin and clomiphene treatment for women with infertility owing to PCOS-related ovulation dysfunction in a randomised controlled trial.

The Australian & New Zealand journal of obstetrics & gynaecology 20110601

How can primary care providers manage pediatric obesity in the real world?

Journal of the American Academy of Nurse Practitioners 20110601

Exenatide improves weight loss insulin sensitivity and β-cell function following administration to a type 2 diabetic HIV patient on antiretroviral therapy.

Annales d'endocrinologie 20110601

Effect of aspirin on the expression of hepatocyte NF-κB and serum TNF-α in streptozotocin-induced type 2 diabetic rats.

Journal of Korean medical science 20110601

Anticancer effects of metformin and its potential use as a therapeutic agent for breast cancer.

Future oncology (London, England) 20110601

Metformin: a new option in cancer treatment.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20110601

Metformin for cancer prevention.

Frontiers of medicine 20110601

Beneficial effects of metformin on primary cardiomyocytes via activation of adenosine monophosphate-activated protein kinase.

Chinese medical journal 20110601

Effects of co-administration of methanol leaf extract of Catharanthus roseus on the hypoglycemic activity of metformin and glibenclamide in rats.

Asian Pacific journal of tropical medicine 20110601

Effectiveness of adding vildagliptin to the treatment of diabetic patients nonresponsive to the combination of metformin and a sulphonylurea.

Arquivos brasileiros de endocrinologia e metabologia 20110601

Recent diabetes issues affecting the primary care clinician.

Southern medical journal 20110601

Effect of folic acid supplementation on homocysteine, serum total antioxidant capacity, and malondialdehyde in patients with type 2 diabetes mellitus.

Journal of the American College of Nutrition 20110601

Therapeutic effects of biguanide vs. statin in polycystic ovary syndrome: a randomized clinical trial.

Pakistan journal of biological sciences : PJBS 20110601

Combined effects of atorvastatin and metformin on glucose-induced variations of inflammatory process in patients with diabetes mellitus.

International journal of cardiology 20110519

Effect of antihyperglycemic agents added to metformin and a sulfonylurea on glycemic control and weight gain in type 2 diabetes: a network meta-analysis.

Annals of internal medicine 20110517

Anti-diabetic effects of mildronate alone or in combination with metformin in obese Zucker rats.

European journal of pharmacology 20110511

Metformin reduces the stimulatory effect of obesity on in vivo Walker-256 tumor development and increases the area of tumor necrosis.

Life sciences 20110509

[Metformin - mechanisms of action and use for the treatment of type 2 diabetes mellitus].

Postepy higieny i medycyny doswiadczalnej (Online) 20110506

Activation of AMP-activated protein kinase may not be involved in AICAR- and metformin-mediated meiotic arrest in bovine denuded and cumulus-enclosed oocytes in vitro.

Zygote (Cambridge, England) 20110501

Effects of metabolic acidosis on expression levels of renal drug transporters.

Pharmaceutical research 20110501

Metformin improves semen characteristics of oligo-terato-asthenozoospermic men with metabolic syndrome.

Fertility and sterility 20110501

Metformin restores endothelial function in aorta of diabetic rats.

British journal of pharmacology 20110501

Metformin associated with lower mortality in diabetic patients with early stage hepatocellular carcinoma after radiofrequency ablation.

Journal of gastroenterology and hepatology 20110501

A 5-week study of the pharmacokinetics and pharmacodynamics of LY2189265, a novel, long-acting glucagon-like peptide-1 analogue, in patients with type 2 diabetes.

Diabetes, obesity & metabolism 20110501

Effects of pioglitazone versus metformin on circulating endothelial microparticles and progenitor cells in patients with newly diagnosed type 2 diabetes--a randomized controlled trial.

Diabetes, obesity & metabolism 20110501

Effect of dose escalation of metformin on clinical features, insulin sensitivity and androgen profile in polycystic ovary syndrome.

European journal of obstetrics, gynecology, and reproductive biology 20110501

Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer's-like changes.

Neuropharmacology 20110501

The effect of a one-year weight reduction program on serum uric acid in overweight/obese children and adolescents.

Clinical chemistry and laboratory medicine 20110501

The metabolic status modulates the effect of metformin on the antimullerian hormone-androgens-insulin interplay in obese women with polycystic ovary syndrome.

The Journal of clinical endocrinology and metabolism 20110501

Insulin therapy has a complex relationship with measure of oxidative stress in type 2 diabetes: a case for further study.

Diabetes/metabolism research and reviews 20110501

Predictors of response to dipeptidyl peptidase-4 inhibitors: evidence from randomized clinical trials.

Diabetes/metabolism research and reviews 20110501

Effects of insulin and oral anti-diabetic agents on glucose metabolism, vascular dysfunction and skeletal muscle inflammation in type 2 diabetic subjects.

Diabetes/metabolism research and reviews 20110501

Diabetes mellitus type 2 through oncology lens.

Medical hypotheses 20110501

Effect of sitagliptin plus metformin on β-cell function, islet integrity and islet gene expression in Zucker diabetic fatty rats.

Diabetes research and clinical practice 20110501

Mevalonate pathway inhibitors affect anticancer drug-induced cell death and DNA damage response of human sarcoma cells.

Cancer letters 20110501

Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types.

Cancer research 20110501

Effects of rosiglitazone, glyburide, and metformin on β-cell function and insulin sensitivity in ADOPT.

Diabetes 20110501

Metformin induces both caspase-dependent and poly(ADP-ribose) polymerase-dependent cell death in breast cancer cells.

Molecular cancer research : MCR 20110501

Preventive therapy for breast cancer: a consensus statement.

The Lancet. Oncology 20110501

Renal function in type 2 diabetes with rosiglitazone, metformin, and glyburide monotherapy.

Clinical journal of the American Society of Nephrology : CJASN 20110501

Determination of rosiglitazone and metformin in human serum by CE-ESI-MS.

Journal of separation science 20110501

Metformin sensitizes insulin signaling through AMPK-mediated PTEN down-regulation in preadipocyte 3T3-L1 cells.

Journal of cellular biochemistry 20110501

Metformin inhibits nuclear receptor TR4-mediated hepatic stearoyl-CoA desaturase 1 gene expression with altered insulin sensitivity.

Diabetes 20110501

Pivotal role of timely basal insulin replacement after metformin failure in sustaining long-term blood glucose control at a target in type 2 diabetes.

Diabetes care 20110501

Comment on: Chen et al. Utilizing the second-meal effect in type 2 diabetes: practical use of a soya-yogurt snack. Diabetes Care 2010;33:2552-2554.

Diabetes care 20110501

Metformin suppresses ovarian cancer growth and metastasis with enhancement of cisplatin cytotoxicity in vivo.

Neoplasia (New York, N.Y.) 20110501

Insulin treatment for type 2 diabetes: when to start, which to use.

Cleveland Clinic journal of medicine 20110501

Metformin activates an ataxia telangiectasia mutated (ATM)/Chk2-regulated DNA damage-like response.

Cell cycle (Georgetown, Tex.) 20110501

Liraglutide for the treatment of type 2 diabetes.

Health technology assessment (Winchester, England) 20110501

Metformin: an effective attenuator of risperidone-induced insulin resistance hyperglycemia and dyslipidemia in rats.

Indian journal of experimental biology 20110501

Type 2 diabetes mellitus: practical approaches for primary care physicians.

The Journal of the American Osteopathic Association 20110501

[Improved virologic response in chronic hepatitis C treated with peginterferon, ribavirin and add-on drug].

Nihon rinsho. Japanese journal of clinical medicine 20110501

Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial.

JAMA 20110427

[Metformin treatment with or without life style changes in patients with polycystic ovary syndrome].

Orvosi hetilap 20110417

Liver kinase B1 (LKB1) in the pathogenesis of UVB-induced murine basal cell carcinoma.

Archives of biochemistry and biophysics 20110415

AMP-activated protein kinase regulates neuronal polarization by interfering with PI 3-kinase localization.

Science (New York, N.Y.) 20110408

AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice.

Cell metabolism 20110406

Electrodeless, accurate pH determination in highly basic media using a new set of (1)H NMR pH indicators.

Journal of pharmaceutical and biomedical analysis 20110405

The effect of comprehensive lifestyle intervention or metformin on obesity in young women.

Nutrition, metabolism, and cardiovascular diseases : NMCD 20110401

The impact of type 2 diabetes and antidiabetic drugs on cancer cell growth.

Journal of cellular and molecular medicine 20110401

The anti-diabetic drug metformin suppresses self-renewal and proliferation of trastuzumab-resistant tumor-initiating breast cancer stem cells.

Breast cancer research and treatment 20110401

The effect of different hormone therapies on anti-müllerian hormone serum levels in anovulatory women of reproductive age.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20110401

Metformin induces Rab4 through AMPK and modulates GLUT4 translocation in skeletal muscle cells.

Journal of cellular physiology 20110401

Metabolic syndrome in severe mental disorders.

Metabolic syndrome and related disorders 20110401

Metformin inhibits HMGB1 release in LPS-treated RAW 264.7 cells and increases survival rate of endotoxaemic mice.

British journal of pharmacology 20110401

Metformin induces osteoblast differentiation via orphan nuclear receptor SHP-mediated transactivation of Runx2.

Bone 20110401

Abnormal metabolism flexibility in response to high palmitate concentrations in myotubes derived from obese type 2 diabetic patients.

Biochimica et biophysica acta 20110401

Self-reported experience of hypoglycemia among adults with type 2 diabetes mellitus (Exhype).

Diabetes research and clinical practice 20110401

Metformin and digestive disorders.

Diabetes & metabolism 20110401

Are sulfonylureas less desirable than DPP-4 inhibitors as add-on to metformin in the treatment of type 2 diabetes?

Current diabetes reports 20110401

Effect of simvastatin and fenofibrate on cytokine release and systemic inflammation in type 2 diabetes mellitus with mixed dyslipidemia.

The American journal of cardiology 20110401

Metformin modulates IL-8, IL-1β, ICAM and IGFBP-1 expression in human endometrial stromal cells.

Reproductive biomedicine online 20110401

Pharmacotherapy: GLP-1 analogues and insulin: sound the wedding bells?

Nature reviews. Endocrinology 20110401

One year of liraglutide treatment offers sustained and more effective glycaemic control and weight reduction compared with sitagliptin, both in combination with metformin, in patients with type 2 diabetes: a randomised, parallel-group, open-label trial.

International journal of clinical practice 20110401

Activation of AMP-kinase by policosanol requires peroxisomal metabolism.

Lipids 20110401

Micro(mi)RNA expression profile of breast cancer epithelial cells treated with the anti-diabetic drug metformin: induction of the tumor suppressor miRNA let-7a and suppression of the TGFβ-induced oncomiR miRNA-181a.

Cell cycle (Georgetown, Tex.) 20110401

Updated genetic score based on 34 confirmed type 2 diabetes Loci is associated with diabetes incidence and regression to normoglycemia in the diabetes prevention program.

Diabetes 20110401

[Recommendations for the pharmacological treatment of hyperglycemia in type 2 diabetes].

Atencion primaria 20110401

Lixisenatide for type 2 diabetes mellitus.

Expert opinion on investigational drugs 20110401

Efficacy and safety of the dipeptidyl peptidase-4 inhibitor PF-734200 added to metformin in Type 2 diabetes.

Diabetic medicine : a journal of the British Diabetic Association 20110401

Diabetes and pancreatic cancer: chicken or egg?

Pancreas 20110401

Antidiabetic treatments and risk of hospitalisation with myocardial infarction: a nationwide case-control study.

Pharmacoepidemiology and drug safety 20110401

Long term patterns of use after initiation of oral antidiabetic drug therapy.

Pharmacoepidemiology and drug safety 20110401

Improvement in metformin and insulin utilisation in the Australian veteran population associated with quality use of medicines intervention programs.

Pharmacoepidemiology and drug safety 20110401

Comment on: Chen et al. utilizing the second-meal effect in type 2 diabetes: practical use of a soya-yogurt snack. Diabetes Care 2010;33:2552–2554.

Diabetes care 20110401

[Efficacy and tolerability of sitagliptin in type 2 diabetic patients inadequately controlled with metformin. A prospective observational study in austrian primary care].

Wiener klinische Wochenschrift 20110401

Metformin is a reasonable first-line treatment option for non-obese women with infertility related to anovulatory polycystic ovary syndrome--a meta-analysis of randomised trials.

The Australian & New Zealand journal of obstetrics & gynaecology 20110401

[Effectiveness of metformin in prevention of development of hyperglycemia and neuronal damage caused by ischemic stress].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20110401

The risks and benefits of implementing glycemic control guidelines in frail older adults with diabetes mellitus.

Journal of the American Geriatrics Society 20110401

Gerosuppressant metformin: less is more.

Aging 20110401

Effects of metformin on plasma concentrations of glucose and mannose, G6Pase and PEPCK activity, and mRNA expression in the liver and kidney of chickens.

British poultry science 20110401

Fecal incontinence resolved using metformin withdrawal.

Journal of the American Geriatrics Society 20110401

Ultra-performance liquid chromatography electrospray ionization-tandem mass spectrometry method for the estimation of miglitol in human plasma using metformin as the internal standard.

Drug testing and analysis 20110401

Relations of adiponectin to levels of metabolic parameters and sexual hormones in elderly type 2 diabetic patients.

Gender medicine 20110401

New therapeutic options: management strategies to optimize glycemic control.

The Journal of the American Osteopathic Association 20110401

[Colorectal cancer and diabetes].

Vnitrni lekarstvi 20110401

[Dyspeptic syndrome associated with antidiabetic therapy].

Vnitrni lekarstvi 20110401

[Therapeutic approaches to improve blood glucose control in a patient with type 2 diabetes on a metformin-sulfonylurea combination].

Revue medicale de Liege 20110401

[Effects of metformin therapy on markers of coagulation disorders in hyperinsulinemic women with polycystic ovary syndrome].

Ginekologia polska 20110401

Diagnosis and management of acromegaly: giant invasive adenoma.

Acta medica Indonesiana 20110401

Hypoglycemic effect of bitter melon compared with metformin in newly diagnosed type 2 diabetes patients.

Journal of ethnopharmacology 20110324

Saxagliptin/metformin (kombiglyze XR) for type 2 diabetes.

The Medical letter on drugs and therapeutics 20110321

Effects of metformin on the reproductive system of androgenized female rats.

Fertility and sterility 20110315

Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo.

Oncogene 20110310

Occult metformin toxicity in three patients with profound lactic acidosis.

The Journal of emergency medicine 20110301

Metformin for weight reduction in non-diabetic patients on antipsychotic drugs: a systematic review and meta-analysis.

Journal of psychopharmacology (Oxford, England) 20110301

The anorexigenic effects of metformin involve increases in hypothalamic leptin receptor expression.

Metabolism: clinical and experimental 20110301

Divergent effects of ethinylestradiol-drospirenone and flutamide-metformin on follistatin in adolescents and women with hyperinsulinemic androgen excess.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20110301

Combined metformin and clomiphene citrate versus highly purified FSH for ovulation induction in clomiphene-resistant PCOS women: a randomised controlled trial.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20110301

Thiazolidinediones plus metformin association on body weight in patients with type 2 diabetes.

Diabetes research and clinical practice 20110301

Effect of combining rosiglitazone with either metformin or insulin on β-cell mass and function in an animal model of Type 2 diabetes characterized by reduced β-cell mass at birth.

Journal of diabetes 20110301

Metformin vs thiazolidinediones for treatment of clinical, hormonal and metabolic characteristics of polycystic ovary syndrome: a meta-analysis.

Clinical endocrinology 20110301

Metformin inhibits P-glycoprotein expression via the NF-κB pathway and CRE transcriptional activity through AMPK activation.

British journal of pharmacology 20110301

Multiple outcomes associated with the use of metformin and sulphonylureas in type 2 diabetes: a population-based cohort study in Italy.

European journal of clinical pharmacology 20110301

Combined metformin and clomiphene citrate versus laparoscopic ovarian diathermy for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a randomized controlled trial.

The journal of obstetrics and gynaecology research 20110301

What to add in with metformin in type 2 diabetes?

QJM : monthly journal of the Association of Physicians 20110301

Metformin-associated lactic acidosis: is it really just an association?

The American journal of emergency medicine 20110301

Metformin treatment exerts antiinvasive and antimetastatic effects in human endometrial carcinoma cells.

The Journal of clinical endocrinology and metabolism 20110301

The effects of metformin with lifestyle therapy in polycystic ovary syndrome: a randomized double-blind study.

Fertility and sterility 20110301

Clinical evidence and mechanistic basis for vildagliptin's action when added to metformin.

Diabetes, obesity & metabolism 20110301

Effect of metformin on cardiovascular events and mortality: a meta-analysis of randomized clinical trials.

Diabetes, obesity & metabolism 20110301

Efficacy and safety of insulin detemir once daily in combination with sitagliptin and metformin: the TRANSITION randomized controlled trial.

Diabetes, obesity & metabolism 20110301

Improved glycemic control induced by both metformin and repaglinide is associated with a reduction in blood levels of 3-deoxyglucosone in nonobese patients with type 2 diabetes.

European journal of endocrinology 20110301

Phosphorylation and activation of AMP-activated protein kinase (AMPK) by metformin in the human ovary requires insulin.

Endocrinology 20110301

Role of decreased circulating hepcidin concentrations in the iron excess of women with the polycystic ovary syndrome.

The Journal of clinical endocrinology and metabolism 20110301

Action of metformin on the insulin-signaling pathway and on glucose transport in human granulosa cells.

The Journal of clinical endocrinology and metabolism 20110301

Oral hypoglycemic agents for gestational diabetes mellitus?

Expert opinion on drug safety 20110301

Rifampin enhances the glucose-lowering effect of metformin and increases OCT1 mRNA levels in healthy participants.

Clinical pharmacology and therapeutics 20110301

Tubular injury in a rat model of type 2 diabetes is prevented by metformin: a possible role of HIF-1α expression and oxygen metabolism.

Diabetes 20110301

Metformin or thiazolidinedione therapy in PCOS?

Nature reviews. Endocrinology 20110301

Metformin for olanzapine-induced weight gain: a systematic review and meta-analysis.

British journal of clinical pharmacology 20110301

Exenatide twice daily versus premixed insulin aspart 70/30 in metformin-treated patients with type 2 diabetes: a randomized 26-week study on glycemic control and hypoglycemia.

Diabetes care 20110301

Lactic acidosis after concomitant treatment with metformin and tenofovir in a patient with HIV infection.

Journal of renal care 20110301

Can modeling of health outcomes facilitate regulatory decision making? The benefit-risk tradeoff for rosiglitazone in 1999 vs. 2007.

Clinical pharmacology and therapeutics 20110301

Sitagliptin and metformin--novel combination therapy.

Expert opinion on pharmacotherapy 20110301

Liraglutide improves treatment satisfaction in people with Type 2 diabetes compared with sitagliptin, each as an add on to metformin.

Diabetic medicine : a journal of the British Diabetic Association 20110301

Which oral agent to use when metformin is no longer effective?

QJM : monthly journal of the Association of Physicians 20110301

[Recommendations for the pharmacological treatment of hyperglycemia in type 2 diabetes].

Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion 20110301

[Recommendations for the pharmacological treatment of hyperglycemia in type 2 diabetes].

Revista clinica espanola 20110301

[Effects of antidiabetic drug metformin on human breast carcinoma cells with different estrogen receptor expressing in vitro].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20110301

[Effect of short-term intensive therapy with glimepiride and metformin in newly diagnosed type 2 diabetic patients].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20110301

Protection of pancreatic INS-1 β-cells from glucose- and fructose-induced cell death by inhibiting mitochondrial permeability transition with cyclosporin A or metformin.

Cell death & disease 20110301

Exploring long-term protection of normal human fibroblasts and epithelial cells from chemotherapy in cell culture.

Oncotarget 20110301

Metformin versus metformin plus rosiglitazone in women with polycystic ovary syndrome.

Chinese medical journal 20110301

Design of a decision support system to help clinicians manage glycemia in patients with type 2 diabetes mellitus.

Journal of diabetes science and technology 20110301

The fixed combination of pioglitazone and metformin improves biomarkers of platelet function and chronic inflammation in type 2 diabetes patients: results from the PIOfix study.

Journal of diabetes science and technology 20110301

[Clinical vignette. Which combination of oral glucose-lowering agents to use after failure of metformin monotherapy in type 2 diabetes?].

Revue medicale de Liege 20110301

When metformin fails in type 2 diabetes mellitus.

Archives of internal medicine 20110227

Insulin and metformin may prevent renal injury in young type 2 diabetic Goto-Kakizaki rats.

European journal of pharmacology 20110225

[Expression of aquaporin 7 in perirenal adipose tissue of Otsuka Long-Evans Tokushima Fatty diabetic rats].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20110218

Genomics: Drugs, diabetes and cancer.

Nature 20110217

[Mini-review BMJ 'rational testing' Praxis 2011;100(2):99-103].

Praxis 20110216

Interaction of phytochemicals with hypoglycemic drugs on glucose uptake in L6 myotubes.

Phytomedicine : international journal of phytotherapy and phytopharmacology 20110215

Sitagliptin/metformin fixed-dose combination: in patients with type 2 diabetes mellitus.

Drugs 20110212

[Short-lasting lactic acidosis after heart arrest].

Ugeskrift for laeger 20110207

Fat redistribution preferentially reflects the anti-inflammatory benefits of pioglitazone treatment.

Metabolism: clinical and experimental 20110201

Database evaluation of the effects of long-term rosiglitazone treatment on cardiovascular outcomes in patients with type 2 diabetes.

Journal of clinical pharmacology 20110201

Metformin plus oral contraceptive may decrease plasma sCD40 ligand in women with PCOS patients.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20110201

Antihyperglycemic effects of baicalin on streptozotocin - nicotinamide induced diabetic rats.

Phytotherapy research : PTR 20110201

Early metformin therapy to delay menarche and augment height in girls with precocious pubarche.

Fertility and sterility 20110201

Aging and TOR: interwoven in the fabric of life.

Cellular and molecular life sciences : CMLS 20110201

Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-α in mice.

Diabetologia 20110201

Evaluation of metformin in early breast cancer: a modification of the traditional paradigm for clinical testing of anti-cancer agents.

Breast cancer research and treatment 20110201

Low HDL cholesterol, metformin use, and cancer risk in type 2 diabetes: the Hong Kong Diabetes Registry.

Diabetes care 20110201

Metformin decreases GnRH- and activin-induced gonadotropin secretion in rat pituitary cells: potential involvement of adenosine 5' monophosphate-activated protein kinase (PRKA).

Biology of reproduction 20110201

Effects of rosiglitazone/metformin fixed-dose combination therapy and metformin monotherapy on serum vaspin, adiponectin and IL-6 levels in drug-naïve patients with type 2 diabetes.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20110201

Diabetes, metformin and lactic acidosis.

Clinical endocrinology 20110201

Interaction of glibenclamide and metformin at the level of translation in pancreatic β cells.

The Journal of endocrinology 20110201

PRKA/AMPK: integrating energy status with fertility in pituitary gonadotrophs.

Biology of reproduction 20110201

New aspects of an old drug: metformin as a glucagon-like peptide 1 (GLP-1) enhancer and sensitiser.

Diabetologia 20110201

When should an insulin sensitizing agent be used in the treatment of polycystic ovary syndrome?

Clinical endocrinology 20110201

AMPK/TSC2/mTOR-signaling intermediates are not necessary for LKB1-mediated nuclear retention of PTEN tumor suppressor.

Neuro-oncology 20110201

Metformin treatment for small benign thyroid nodules in patients with insulin resistance.

Metabolic syndrome and related disorders 20110201

Study comparing the effect of pioglitazone in combination with either metformin or sulphonylureas on lipid profile and glycaemic control in patients with type 2 diabetes (ECLA).

Current medical research and opinion 20110201

Metformin improves cardiac function in rats via activation of AMP-activated protein kinase.

Clinical and experimental pharmacology & physiology 20110201

Metformin and the incidence of prostate cancer in patients with type 2 diabetes.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20110201

Prenatal androgenization of female mice programs an increase in firing activity of gonadotropin-releasing hormone (GnRH) neurons that is reversed by metformin treatment in adulthood.

Endocrinology 20110201

Improved glycaemic control with reduced hypoglycaemic episodes and without weight gain using long-term modern premixed insulins in type 2 diabetes.

International journal of clinical practice 20110201

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes.

Nature genetics 20110201

Pharmacological management of type 2 diabetes: the potential of incretin-based therapies.

Diabetes, obesity & metabolism 20110201

Efficacy and safety of treatment with sitagliptin or glimepiride in patients with type 2 diabetes inadequately controlled on metformin monotherapy: a randomized, double-blind, non-inferiority trial.

Diabetes, obesity & metabolism 20110201

Phosphoprotein enriched in diabetes gene product (Ped/pea-15) is increased in omental adipose tissue of women with the polycystic ovary syndrome: ex vivo regulation of ped/pea-15 by glucose, insulin and metformin.

Diabetes, obesity & metabolism 20110201

Simultaneous determination and pharmacokinetic study of metformin and rosiglitazone in human plasma by HPLC-ESI-MS.

Journal of chromatographic science 20110201

Effects of metformin on body weight and body composition in obese insulin-resistant children: a randomized clinical trial.

Diabetes 20110201

Clinical pharmacokinetics of metformin.

Clinical pharmacokinetics 20110201

Oral hypoglycaemic agents during pregnancy: The evidence for effectiveness and safety.

Best practice & research. Clinical obstetrics & gynaecology 20110201

Metformin reverses progestin resistance in endometrial cancer cells by downregulating GloI expression.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20110201

Pharmacotherapy for obese adolescents.

Pediatric clinics of North America 20110201

[Perioperative management of chronic treatment and medical devices. Endocrine pathology].

Annales francaises d'anesthesie et de reanimation 20110201

If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice.

Aging 20110201

Optimizing outcomes for GLP-1 agonists.

The Journal of the American Osteopathic Association 20110201

[Metformin prevents non-alcoholic fatty liver disease in rats: role of phospholipase A2/lysophosphatidylcholine lipoapoptosis pathway in hepatocytes].

Zhonghua er ke za zhi = Chinese journal of pediatrics 20110201

Diabetes drug could work against Alzheimer's, animal study suggests.

Pakistan journal of biological sciences : PJBS 20110201

AMP-activated protein kinase (AMPK) positively regulates osteoblast differentiation via induction of Dlx5-dependent Runx2 expression in MC3T3E1 cells.

Biochemical and biophysical research communications 20110128

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy.

Science (New York, N.Y.) 20110128

Polyphenols-rich Vernonia amygdalina shows anti-diabetic effects in streptozotocin-induced diabetic rats.

Journal of ethnopharmacology 20110127

In vitro and in vivo acute antihyperglycemic effects of five selected indigenous plants from Jordan used in traditional medicine.

Journal of ethnopharmacology 20110127

Metformin reduces cisplatin-mediated apoptotic death of cancer cells through AMPK-independent activation of Akt.

European journal of pharmacology 20110125

Summaries for patients: Does adding exenatide to insulin treatment benefit patients with type 2 diabetes?

Annals of internal medicine 20110118

Use of twice-daily exenatide in Basal insulin-treated patients with type 2 diabetes: a randomized, controlled trial.

Annals of internal medicine 20110118

Metformin activates AMP kinase through inhibition of AMP deaminase.

The Journal of biological chemistry 20110107

Metformin attenuates ovarian cancer cell growth in an AMP-kinase dispensable manner.

Journal of cellular and molecular medicine 20110101

Addition of metformin to exogenous glucagon-like peptide-1 results in increased serum glucagon-like peptide-1 concentrations and greater glucose lowering in type 2 diabetes mellitus.

Metabolism: clinical and experimental 20110101

Does long-term metformin treatment increase cardiac lipoprotein lipase?

Metabolism: clinical and experimental 20110101

Effect of the insulin sensitizers metformin and pioglitazone on endothelial function in young women with polycystic ovary syndrome: a prospective randomized study.

Fertility and sterility 20110101

Efficacy and safety of metformin for treatment of type 2 diabetes in elderly Japanese patients.

Geriatrics & gerontology international 20110101

A comparison of twice-daily biphasic insulin aspart 70/30 and once-daily insulin glargine in persons with type 2 diabetes mellitus inadequately controlled on basal insulin and oral therapy: a randomized, open-label study.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20110101

Statin therapy improves sustained virologic response among diabetic patients with chronic hepatitis C.

Gastroenterology 20110101

Iatrogenic hyperhomocysteinemia in patients with metabolic syndrome: a systematic review and metaanalysis.

Atherosclerosis 20110101

Pharmacological treatment of the pathogenetic defects in type 2 diabetes: the randomized multicenter South Danish Diabetes Study.

Diabetes care 20110101

AMP-activated protein kinase regulates glucagon secretion from mouse pancreatic alpha cells.

Diabetologia 20110101

Metformin can activate imidazoline I-2 receptors to lower plasma glucose in type 1-like diabetic rats.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20110101

Differential effects of rosiglitazone and metformin on postprandial lipemia in patients with HIV-lipodystrophy.

Arteriosclerosis, thrombosis, and vascular biology 20110101

Metformin use and mortality in ambulatory patients with diabetes and heart failure.

Circulation. Heart failure 20110101

OCT1 Expression in adipocytes could contribute to increased metformin action in obese subjects.

Diabetes 20110101

Effect of pioglitazone on serum concentrations of osteoprotegerin in patients with type 2 diabetes mellitus.

European journal of endocrinology 20110101

Metformin and cancer occurrence in insulin-treated type 2 diabetic patients.

Diabetes care 20110101

Metformin in type 1 diabetes reduces insulin requirements without significantly improving glycaemic control. Reply to Schatz H [letter].

Diabetologia 20110101

Glucose homeostasis in rainbow trout fed a high-carbohydrate diet: metformin and insulin interact in a tissue-dependent manner.

American journal of physiology. Regulatory, integrative and comparative physiology 20110101

Metformin attenuates ventricular hypertrophy by activating the AMP-activated protein kinase-endothelial nitric oxide synthase pathway in rats.

Clinical and experimental pharmacology & physiology 20110101

Relationship between serum osteocalcin and glycaemic variability in Type 2 diabetes.

Clinical and experimental pharmacology & physiology 20110101

The anti-diabetic drug metformin suppresses the metastasis-associated protein CD24 in MDA-MB-468 triple-negative breast cancer cells.

Oncology reports 20110101

Lack of pharmacokinetic interaction between dapagliflozin, a novel sodium-glucose transporter 2 inhibitor, and metformin, pioglitazone, glimepiride or sitagliptin in healthy subjects.

Diabetes, obesity & metabolism 20110101

Safety and efficacy of linagliptin as add-on therapy to metformin in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled study.

Diabetes, obesity & metabolism 20110101

Liraglutide provides similar glycaemic control as glimepiride (both in combination with metformin) and reduces body weight and systolic blood pressure in Asian population with type 2 diabetes from China, South Korea and India: a 16-week, randomized, double-blind, active control trial(*).

Diabetes, obesity & metabolism 20110101

Effect of sulphonylurea treatment on glycaemic control is related to TCF7L2 genotype in patients with type 2 diabetes.

Diabetes, obesity & metabolism 20110101

Metformin and incident breast cancer among diabetic women: a population-based case-control study in Denmark.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20110101

Management of type 2 diabetes: evolving strategies for the treatment of patients with type 2 diabetes.

Metabolism: clinical and experimental 20110101

Achieving glycemic goal with initial versus sequential combination therapy using metformin and pioglitazone in type 2 diabetes mellitus.

Current medical research and opinion 20110101

Add-on therapies to metformin for type 2 diabetes.

Expert opinion on pharmacotherapy 20110101

Metformin may maintain weight loss in obese patients with dysglycaemia initially treated with rimonabant.

Diabetic medicine : a journal of the British Diabetic Association 20110101

Guideline-conformity of initiation with oral hypoglycemic treatment for patients with newly therapy-dependent type 2 diabetes mellitus in Austria.

Pharmacoepidemiology and drug safety 20110101

Clinical pearls in general internal medicine.

Mayo Clinic proceedings 20110101

[Fatty liver and its clinical management in obese adolescents].

Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion 20110101

Metformin and atorvastatin combination further protect the liver in type 2 diabetes with hyperlipidaemia.

Diabetes/metabolism research and reviews 20110101

Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: a representative population prospective cohort study of 800,000 individuals.

BMC cancer 20110101

Chemoprevention of hormone receptor-negative breast cancer: new approaches needed.

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 20110101

Metformin decreases thyrotropin in overweight women with polycystic ovarian syndrome and hypothyroidism.

Diabetes & vascular disease research 20110101

Electroconvulsive therapy for the treatment of refractory mania.

Journal of psychiatric practice 20110101

Recommendations for the pharmacologic treatment of hyperglycemia in type 2 diabetes. Consensus document.

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20110101

Advantages of extended-release metformin in patients with type 2 diabetes mellitus.

Postgraduate medicine 20110101

Incidence of dementia is increased in type 2 diabetes and reduced by the use of sulfonylureas and metformin.

Journal of Alzheimer's disease : JAD 20110101

Insulin resistance: pathophysiology and rationale for treatment.

Annals of nutrition & metabolism 20110101

Environmental and genetic preconditioning for long-term anoxia responses requires AMPK in Caenorhabditis elegans.

PloS one 20110101

Management of cardiovascular risk factors with pioglitazone combination therapies in type 2 diabetes: an observational cohort study.

Cardiovascular diabetology 20110101

The effect of weight loss and treatment with metformin on serum vaspin levels in women with polycystic ovary syndrome.

Endocrine journal 20110101

Metformin: the safest hypoglycaemic agent in chronic kidney disease?

Nephron. Clinical practice 20110101

Comparison of antioxidant effects of honey, glibenclamide, metformin, and their combinations in the kidneys of streptozotocin-induced diabetic rats.

International journal of molecular sciences 20110101

Metformin-induced lactic acidosis: no one left behind.

Critical care (London, England) 20110101

Metformin: its emerging role in oncology.

Hormones (Athens, Greece) 20110101

[Metformin in type 2 diabetes. An extensive observational study confirms the agent as first choice--so far].

Lakartidningen 20110101

In vitro and in vivo effects of metformin on human adipose tissue adiponectin.

Obesity facts 20110101

Determination of metformin hydrochloride using precolumn derivatization with acetaldehyde and capillary electrophoresis coupled with electrochemiluminescence.

Luminescence : the journal of biological and chemical luminescence 20110101

Vitamin B12 in metformin-treated diabetic patients: a cross-sectional study in Brazil.

Revista da Associacao Medica Brasileira (1992) 20110101

The value of sex hormone binding globulin (SHBG) in predicting treatment response in polycystic ovary syndrome (PCOS).

Clinical laboratory 20110101

Establishment of a database of metformin plasma concentrations and erythrocyte levels in normal and emergency situations.

Clinical drug investigation 20110101

Glibenclamide or metformin combined with honey improves glycemic control in streptozotocin-induced diabetic rats.

International journal of biological sciences 20110101

[Plasmapheresis as treatment for severe hypertriglyceridemia].

Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion 20110101

Total cholesterol, high density lipoprotein and triglyceride for cardiovascular disease in elderly patients treated with metformin.

Archives of pharmacal research 20110101

Understanding the benefit of metformin use in cancer treatment.

BMC medicine 20110101

Targeting type 2 diabetes.

Handbook of experimental pharmacology 20110101

Determinants of an optimal response to pioglitazone in terms of HDL-cholesterol.

Internal medicine (Tokyo, Japan) 20110101

[Metformin slows down ageing processes at the cellular level in SHR mice].

Tsitologiia 20110101

Prolonged hemodialysis for severe metformin intoxication.

Renal failure 20110101

[Metformin-induced lactic acidosis due to acute renal failure].

Anales del sistema sanitario de Navarra 20110101

Concomitant oral antihyperglycemic agent use and associated treatment outcomes after initiation of insulin therapy.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20110101

Repositioning chloroquine and metformin to eliminate cancer stem cell traits in pre-malignant lesions.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 20110101

Combination therapy with vemurafenib (PLX4032/RG7204) and metformin in melanoma cell lines with distinct driver mutations.

Journal of translational medicine 20110101

[Therapeutic approach to dyslipidemia and goal achievement in a Spanish population with type 2 diabetes without cardiovascular disease].

Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion 20110101

Mechanism of AMPK suppression of LXR-dependent Srebp-1c transcription.

International journal of biological sciences 20110101

Effects of metformin and rosiglitazone on peripheral insulin resistance and β-cell function in obesity: a double-blind, randomized, controlled study.

The Journal of international medical research 20110101

Variation in KCNQ1 is associated with therapeutic response to sulphonylureas.

Medical science monitor : international medical journal of experimental and clinical research 20110101

Obesity and type 2 diabetes mellitus in South Dakota: focused insight into prevalence, physiology and treatment.

South Dakota medicine : the journal of the South Dakota State Medical Association 20110101

The effect of metformin on the myocardial tolerance to ischemia-reperfusion injury in the rat model of diabetes mellitus type II.

Experimental diabetes research 20110101

Double-blind, randomized, multicentre, and active comparator controlled investigation of the effect of pioglitazone, metformin, and the combination of both on cardiovascular risk in patients with type 2 diabetes receiving stable basal insulin therapy: the PIOCOMB study.

Cardiovascular diabetology 20110101

Pancreatogenic diabetes: special considerations for management.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20110101

Metformin plus temozolomide-based chemotherapy as adjuvant treatment for WHO grade III and IV malignant gliomas.

Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20110101

Latin American consensus: children born small for gestational age.

BMC pediatrics 20110101

Antidiabetic drug metformin induces apoptosis in human MCF breast cancer via targeting ERK signaling.

Oncology research 20110101

Proton pump inhibitors inhibit metformin uptake by organic cation transporters (OCTs).

PloS one 20110101

The effect of an intracerebroventricular injection of metformin or AICAR on the plasma concentrations of melatonin in the ewe: potential involvement of AMPK?

BMC neuroscience 20110101

Inhibitory effect of metformin on oxidation of NADH-dependent substrates in rat liver homogenate.

Physiological research 20110101

The beneficial effect of α-glucosidase inhibitor on glucose variability compared with sulfonylurea in Taiwanese type 2 diabetic patients inadequately controlled with metformin: preliminary data.

Journal of diabetes and its complications 20110101

Bioequivalence of saxagliptin/metformin extended-release (XR) fixed-dose combination tablets and single-component saxagliptin and metformin XR tablets in healthy adult subjects.

Clinical drug investigation 20110101

What your doctor is reading.

Diabetes self-management 20110101

Management of metformin-associated lactic acidosis by continuous renal replacement therapy.

PloS one 20110101

Colesevelam hydrochloride added to background metformin therapy in patients with type 2 diabetes mellitus: a pooled analysis from 3 clinical studies.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20110101

The Hirsute woman: challenges in evaluation and management.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20110101

Nutritional improvement of metabolic syndrome parameters in immature fructose-fed wild-type mice.

Molecular medicine reports 20110101

Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153.

Neoplasma 20110101

Metformin treatment has no beneficial effect in a dose-response survival study in the SOD1(G93A) mouse model of ALS and is harmful in female mice.

PloS one 20110101

Formulation and evaluation of metformin oro-dispersible tablets.

Acta poloniae pharmaceutica 20110101

RLIP76, a glutathione-conjugate transporter, plays a major role in the pathogenesis of metabolic syndrome.

PloS one 20110101

[Efficacy of metformin as initial therapy in patients with coronary artery disease and diabetes type 2].

Likars'ka sprava 20110101

The nephrologist's role in metformin-induced lactic acidosis.

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20110101

Metformin-induced lactic acidosis: usefulness of measuring levels and therapy with high-flux haemodialysis.

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20110101

[Metformin in adolescents and adults with type 1 diabetes mellitus: not evidence-based].

Nederlands tijdschrift voor geneeskunde 20110101

[Reactive-dystrophic processes in salivary glands (sialoadenoses) running on the background of metabolic syndrome].

Stomatologiia 20110101

Simultaneous spectrophotometric determination of metformin hydrochloride and glibenclamide in binary mixtures using combined discrete and continuous wavelet transforms.

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20110101

Metformin-associated lactic acidosis in Chinese patients with type II diabetes.

Pharmacology 20110101

Metformin restores the correlation between serum-oxidized LDL and leptin levels in type 2 diabetic patients.

Redox report : communications in free radical research 20110101

Antidiabetic pharmacology: a link between metabolic syndrome and neuro-oncology?

Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20110101

[Guideline: type 2 diabetes mellitus therapy: metformin, a critical perspective].

Acta medica portuguesa 20110101

Changes in labelling for metformin use in patients with type 2 diabetes and heart failure: documented safety outweighs theoretical risks.

Open medicine : a peer-reviewed, independent, open-access journal 20110101

Second-line therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy: a systematic review and mixed-treatment comparison meta-analysis.

Open medicine : a peer-reviewed, independent, open-access journal 20110101

Role of activation of 5'-adenosine monophosphate-activated protein kinase in gastric ulcer healing in diabetic rats.

Pharmacology 20110101

Development and validation of new assay method for the simultaneous analysis of diltiazem, metformin, pioglitazone and rosiglitazone by RP-HPLC and its applications in pharmaceuticals and human serum.

Journal of chromatographic science 20110101

Combination therapy with metformin and fenofibrate for insulin resistance in obesity.

The Journal of international medical research 20110101

[Severe lactic acidosis due to metformin: report of 3 cases].

Annales de biologie clinique 20110101

Metformin represses self-renewal of the human breast carcinoma stem cells via inhibition of estrogen receptor-mediated OCT4 expression.

PloS one 20110101

Metformin and lactic acidosis.

Acta clinica Belgica 20110101

Metformin-associated lactic acidosis (MALA): case report.

Acta clinica Belgica 20110101

Risk of death and cardiovascular outcomes with thiazolidinediones: a study with the general practice research database and secondary care data.

PloS one 20110101

AMP-activated protein kinase (AMPK) mediates nutrient regulation of thioredoxin-interacting protein (TXNIP) in pancreatic beta-cells.

PloS one 20110101

Metabolomics reveals reduction of metabolic oxidation in women with polycystic ovary syndrome after pioglitazone-flutamide-metformin polytherapy.

PloS one 20110101

[Breast cancer subtypes and their endocrine-metabolic basis; practical aspects].

Voprosy onkologii 20110101

[Antidiabetes drug metformin is a donor of nitric oxide: ESR measurement of efficiency].

Biofizika 20110101

Drug-drug interaction study between a novel oral ibandronate formulation and metformin.

Arzneimittel-Forschung 20110101

Metformin plus temozolomide-based chemotherapy as adjuvant treatment for WHO grade III and IV malignant gliomas.

Journal of B.U.ON. : official journal of the Balkan Union of Oncology 20110101

[Effectiveness of aromatase inhibitors in comparison with metformin for neoadjuvant treatment in patients with endometrial cancer].

Voprosy onkologii 20110101

Probable hepatotoxicity associated with the use of metformin in type 2 diabetes.

BMJ case reports 20110101

Metformin and insomnia: an interesting story.

Diabetes & metabolic syndrome 20110101

Development and validation of a stability indicating capillary electrophoresis method for the determination of metformin hydrochloride in tablets.

Journal of pharmaceutical and biomedical analysis 20101215

Holiday reading: Learning medicine through riddles.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20101214

Synthesis and biological activity of trans-tiliroside derivatives as potent anti-diabetic agents.

Molecules (Basel, Switzerland) 20101210

[Metformin treatment causes persisting lactic acidosis after cardiac arrest].

Ugeskrift for laeger 20101206

[New clinical data with metformin therapy in patients with diabetes mellitus].

Orvosi hetilap 20101205

Failure to metformin and insulin secretagogue monotherapy: an observational cohort study.

Acta diabetologica 20101201

Baseline atherosclerosis parameter could assess the risk of bone loss during pioglitazone treatment in type 2 diabetes mellitus.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20101201

Fertility treatment in women with polycystic ovary syndrome: a decision analysis of different oral ovulation induction agents.

Fertility and sterility 20101201

Low-dose pioglitazone, flutamide, metformin plus an estro-progestagen for non-obese young women with polycystic ovary syndrome: increasing efficacy and persistent safety over 30 months.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20101201

Metformin 2,500 mg/day in the treatment of obese women with polycystic ovary syndrome and its effect on weight, hormones, and lipid profile.

Archives of gynecology and obstetrics 20101201

Efficacy of metformin therapy in adolescent girls with androgen excess: relation to sex hormone-binding globulin and androgen receptor polymorphisms.

Fertility and sterility 20101201

Insulin-sensitizing agents in the treatment of polycystic ovary syndrome: an update.

Current opinion in obstetrics & gynecology 20101201

Diabetes and cancer.

QJM : monthly journal of the Association of Physicians 20101201

Novel drugs in familial combined hyperlipidemia: lessons from type 2 diabetes mellitus.

Current opinion in lipidology 20101201

Negative regulation of stress-induced matrix metalloproteinase-9 by Sirt1 in skin tissue.

Experimental dermatology 20101201

Mechanisms of metformin action on glucose transport and metabolism in human adipocytes.

Biochemical pharmacology 20101201

Investigation of Metformin HCl lot-to-lot variation on flowability differences exhibited during drug product processing.

Journal of pharmaceutical sciences 20101201

Metformin treatment is associated with a low risk of mortality in diabetic patients with heart failure: a retrospective nationwide cohort study.

Diabetologia 20101201

Protective effect of Clerodendron glandulosum extract against experimentally induced metabolic syndrome in rats.

Pharmaceutical biology 20101201

Genetic downregulation of AMPK-alpha isoforms uncovers the mechanism by which metformin decreases FA uptake and oxidation in skeletal muscle cells.

American journal of physiology. Cell physiology 20101201

Metformin treatment may increase omentin-1 levels in women with polycystic ovary syndrome.

Diabetes 20101201

Sitagliptin attenuates metformin-mediated AMPK phosphorylation through inhibition of organic cation transporters.

Xenobiotica; the fate of foreign compounds in biological systems 20101201

Acute and long-term effects of metformin on the function and insulin secretory responsiveness of clonal β-cells.

Biological chemistry 20101201

Metformin versus placebo from first trimester to delivery in polycystic ovary syndrome: a randomized, controlled multicenter study.

The Journal of clinical endocrinology and metabolism 20101201

AMPK as a therapeutic target in renal cell carcinoma.

Cancer biology & therapy 20101201

A placebo-controlled trial of exenatide twice-daily added to thiazolidinediones alone or in combination with metformin.

Diabetes, obesity & metabolism 20101201

Effects of metformin on BRIN-BD11 beta-cell insulin secretory desensitization induced by prolonged exposure to sulphonylureas.

Diabetes, obesity & metabolism 20101201

Limitations of metformin use in patients with kidney disease: are they warranted?

Diabetes, obesity & metabolism 20101201

Remission of diabetes mellitus type 2 with severe hyperglycemia after Exenatide treatment.

Diabetes research and clinical practice 20101201

Dipeptidyl peptidase-4 inhibitors administered in combination with metformin result in an additive increase in the plasma concentration of active GLP-1.

Clinical pharmacology and therapeutics 20101201

Serum sialic acid changes in type 2 diabetic patients on metformin or rosiglitazone treatment.

Journal of clinical pharmacy and therapeutics 20101201

AMPK signaling: a targetable tumor suppressor pathway?

Cancer biology & therapy 20101201

Linagliptin (BI 1356), a potent and selective DPP-4 inhibitor, is safe and efficacious in combination with metformin in patients with inadequately controlled Type 2 diabetes.

Diabetic medicine : a journal of the British Diabetic Association 20101201

Impact of medication discontinuation on increased intestinal FDG accumulation in diabetic patients treated with metformin.

AJR. American journal of roentgenology 20101201

Therapeutic trials in nonalcoholic steatohepatitis: insulin sensitizers and related methodological issues.

Hepatology (Baltimore, Md.) 20101201

Continuous glucose monitoring reveals different glycemic responses of moderate- vs high-carbohydrate lunch meals in people with type 2 diabetes.

Journal of the American Dietetic Association 20101201

Utilizing the second-meal effect in type 2 diabetes: practical use of a soya-yogurt snack.

Diabetes care 20101201

Considering options for attenuating postmeal glucose excursions.

Diabetes care 20101201

Effects of pioglitazone and metformin fixed-dose combination therapy on cardiovascular risk markers of inflammation and lipid profile compared with pioglitazone and metformin monotherapy in patients with type 2 diabetes.

Journal of clinical hypertension (Greenwich, Conn.) 20101201

Impact of treatment with metformin on adipokines in patients with polycystic ovary syndrome.

European cytokine network 20101201

Metformin during pregnancy in polycystic ovary syndrome: another vitamin bites the dust.

The Journal of clinical endocrinology and metabolism 20101201

Old age may not be a contraindication to the use of metformin.

Journal of the Chinese Medical Association : JCMA 20101201

Fasting plasma lactate concentrations in ambulatory elderly patients with type 2 diabetes receiving metformin therapy: a retrospective cross-sectional study.

Journal of the Chinese Medical Association : JCMA 20101201

[Antidiabetic therapy--a new possibility in the complex therapy of cancer?].

Magyar onkologia 20101201

Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice.

Aging 20101201

[Induction of ovulation].

Journal de gynecologie, obstetrique et biologie de la reproduction 20101201

A new shine on an old med. The story of metformin's past, present, and possible future.

Diabetes forecast 20101201

Metformin and sex: Why suppression of aging may be harmful to young male mice.

Aging 20101201

[Metformin as the first line antidiabetic agent].

Vnitrni lekarstvi 20101201

[Limited sampling strategy to estimate pharmacokinetic parameters of orally administered metformin hydrochloride].

Yao xue xue bao = Acta pharmaceutica Sinica 20101201

Appropriate insulin initiation dosage for insulin-naive type 2 diabetes outpatients receiving insulin monotherapy or in combination with metformin and/or pioglitazone.

Chinese medical journal 20101201

Metformin use and mortality among patients with diabetes and atherothrombosis.

Archives of internal medicine 20101122

The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation.

Blood 20101118

Metformin against TGFβ-induced epithelial-to-mesenchymal transition (EMT): from cancer stem cells to aging-associated fibrosis.

Cell cycle (Georgetown, Tex.) 20101115

Determination of metformin in mouse, rat, dog and human plasma samples by laser diode thermal desorption/atmospheric pressure chemical ionization tandem mass spectrometry.

Journal of pharmaceutical and biomedical analysis 20101102

Effects of metformin plus simvastatin on polycystic ovary syndrome: a prospective, randomized, double-blind, placebo-controlled study.

Fertility and sterility 20101101

Adiponectin levels in women with polycystic ovary syndrome: impact of metformin treatment in a randomized controlled study.

Fertility and sterility 20101101

Effects of metformin and leuprolide acetate on insulin resistance and testosterone levels in nondiabetic postmenopausal women: a randomized, placebo-controlled trial.

Fertility and sterility 20101101

Metformin, naltrexone, or the combination of prednisolone and antiandrogenic oral contraceptives as first-line therapy in hyperinsulinemic women with polycystic ovary syndrome.

Fertility and sterility 20101101

pH 6.68--surviving severe metformin intoxication.

QJM : monthly journal of the Association of Physicians 20101101

Transient vision loss in a patient with metformin-associated lactic acidosis.

The American journal of emergency medicine 20101101

Clinical outcomes after radical prostatectomy in diabetic patients treated with metformin.

Urology 20101101

AMP-activated protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of transcription 3 (STAT3).

Diabetologia 20101101

Safety and tolerability of vildagliptin vs. thiazolidinedione as add-on to metformin in type 2 diabetic patients with and without mild renal impairment: a retrospective analysis of the GALIANT study.

Diabetes research and clinical practice 20101101

AMP kinase acts as a negative regulator of RANKL in the differentiation of osteoclasts.

Bone 20101101

Oral hypoglycemic agents vs insulin in management of gestational diabetes: a systematic review and metaanalysis.

American journal of obstetrics and gynecology 20101101

Saxagliptin is non-inferior to glipizide in patients with type 2 diabetes mellitus inadequately controlled on metformin alone: a 52-week randomised controlled trial.

International journal of clinical practice 20101101

Effects of metformin in experimental stroke.

Stroke 20101101

Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Bioorganic & medicinal chemistry letters 20101101

Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin.

Pharmacogenetics and genomics 20101101

Glycemic and weight changes after persistent use of incident oral diabetes therapy: a Veterans Administration retrospective cohort study.

Pharmacoepidemiology and drug safety 20101101

N-acetyl cysteine plus clomiphene citrate versus metformin and clomiphene citrate in treatment of clomiphene-resistant polycystic ovary syndrome: a randomized controlled trial.

Journal of women's health (2002) 20101101

Metformin and cancer risk in diabetic patients: a systematic review and meta-analysis.

Cancer prevention research (Philadelphia, Pa.) 20101101

Meta-analysis: insulin sensitizers for the treatment of non-alcoholic steatohepatitis.

Alimentary pharmacology & therapeutics 20101101

Regression to normoglycaemia by fenofibrate in pre-diabetic subjects complicated with hypertriglyceridaemia: a prospective randomized controlled trial.

Diabetic medicine : a journal of the British Diabetic Association 20101101

Diabetes mellitus and increased risk of cancer: focus on metformin and the insulin analogs.

Pharmacotherapy 20101101

A randomized, triple masked, placebo-controlled clinical trial for controlling childhood obesity.

World journal of pediatrics : WJP 20101101

Metformin for aging and cancer prevention.

Aging 20101101

Pronounced weight gain in insulin-treated patients with type 2 diabetes mellitus is associated with an unfavourable cardiometabolic risk profile.

The Netherlands journal of medicine 20101101

Does metformin increase the risk of fatal or nonfatal lactic acidosis?

American family physician 20101101

[Tough glucose reduction necessary in newly diagnosed diabetes].

Lakartidningen 20101101

[Medication of the month. Sitagliptin-metformin fixed combination (Janumet)].

Revue medicale de Liege 20101101

Successful strategy to improve glucose tolerance in Thai obese youth.

Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20101101

Post-prandial carbohydrate modulation via gut--Indian perspective.

The Journal of the Association of Physicians of India 20101101

A prospective, parallel group, open-labeled, comparative, multi-centric, active controlled study to evaluate the safety, tolerability and benefits of fixed dose combination of acarbose and metformin versus metformin alone in type 2 diabetes.

The Journal of the Association of Physicians of India 20101101

Rosiglitazone plus metformin to prevent type 2 diabetes mellitus.

Lancet (London, England) 20101023

Rosiglitazone plus metformin to prevent type 2 diabetes mellitus.

Lancet (London, England) 20101023

Rosiglitazone plus metformin to prevent type 2 diabetes mellitus.

Lancet (London, England) 20101023

AMPK-dependent repression of hepatic gluconeogenesis via disruption of CREB.CRTC2 complex by orphan nuclear receptor small heterodimer partner.

The Journal of biological chemistry 20101015

Comparison of effects of 3 mg drospirenone plus 20 μg ethinyl estradiol alone or combined with metformin or cyproterone acetate on classic metabolic cardiovascular risk factors in nonobese women with polycystic ovary syndrome.

Fertility and sterility 20101001

The effect of metformin treatment for 2 years without caloric restriction on endocrine and metabolic parameters in women with polycystic ovary syndrome.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20101001

Treatment of clinical insulin resistance in children: a systematic review.

Obesity reviews : an official journal of the International Association for the Study of Obesity 20101001

[Metformin-associated hepatotoxicity].

Medicina intensiva 20101001

The effect of metformin on anthropometrics and insulin resistance in patients receiving atypical antipsychotic agents: a meta-analysis.

The Journal of clinical psychiatry 20101001

Direct healthcare costs of patients with type 2 diabetes using long-acting insulin analogues or NPH insulin in a basal insulin-only regimen.

Primary care diabetes 20101001

Comparison of metformin and clomiphene citrate therapy for induction of ovulation in the polycystic ovary syndrome.

Archives of gynecology and obstetrics 20101001

Comparison of potential risks of lactic acidosis induction by biguanides in rats.

Regulatory toxicology and pharmacology : RTP 20101001

Efficacy of primary prevention interventions when fasting and postglucose dysglycemia coexist: analysis of the Indian Diabetes Prevention Programmes (IDPP-1 and IDPP-2).

Diabetes care 20101001

Metformin compared with glyburide for the management of gestational diabetes.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20101001

Relationships between daily acute glucose fluctuations and cognitive performance among aged type 2 diabetic patients.

Diabetes care 20101001

Generation, validation and humanisation of a novel insulin resistant cell model.

Biochemical pharmacology 20101001

Multifactorial treatment increases endothelial progenitor cells in patients with type 2 diabetes.

Diabetologia 20101001

Metformin in type 1 diabetes reduces insulin requirements without significantly improving glycaemic control.

Diabetologia 20101001

Genetic polymorphisms in organic cation transporter 1 (OCT1) in Chinese and Japanese populations exhibit altered function.

The Journal of pharmacology and experimental therapeutics 20101001

Metformin and placebo therapy both improve weight management and fasting insulin in obese insulin-resistant adolescents: a prospective, placebo-controlled, randomized study.

European journal of endocrinology 20101001

Hepatotoxicity associated with metformin therapy in treatment of type 2 diabetes mellitus with nonalcoholic fatty liver disease.

The Annals of pharmacotherapy 20101001

Organic cation transporter 1 polymorphisms predict the metabolic response to metformin in women with the polycystic ovary syndrome.

The Journal of clinical endocrinology and metabolism 20101001

National survey on management of weight reduction in PCOS women in the United Kingdom.

European journal of obstetrics, gynecology, and reproductive biology 20101001

Metformin is associated with improved left ventricular diastolic function measured by tissue Doppler imaging in patients with diabetes.

European journal of endocrinology 20101001

Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program.

Diabetes 20101001

Pharmacokinetic and pharmacodynamic evaluation of sitagliptin plus metformin.

Expert opinion on drug metabolism & toxicology 20101001

Metformin and energy metabolism in breast cancer: from insulin physiology to tumour-initiating stem cells.

Current molecular medicine 20101001

Decision trees for identifying predictors of treatment effectiveness in clinical trials and its application to ovulation in a study of women with polycystic ovary syndrome.

Human reproduction (Oxford, England) 20101001

Metabolic syndrome with the atypical antipsychotics.

Current opinion in endocrinology, diabetes, and obesity 20101001

Treatment of polycystic ovary syndrome (PCOS) with metformin ameliorates insulin resistance in parallel with the decrease of serum interleukin-6 concentrations.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20101001

Saxagliptin and metformin XR combination therapy provides glycemic control over 24 hours in patients with T2DM inadequately controlled with metformin.

Current medical research and opinion 20101001

Efficacy and safety of saxagliptin in combination with metformin compared with sitagliptin in combination with metformin in adult patients with type 2 diabetes mellitus.

Diabetes/metabolism research and reviews 20101001

Effect of pioglitazone and acarbose on endothelial inflammation biomarkers during oral glucose tolerance test in diabetic patients treated with sulphonylureas and metformin.

Journal of clinical pharmacy and therapeutics 20101001

Ovulation induction in polycystic ovary syndrome: No. 242, May 2010.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20101001

Pharmacotherapy of ovarian hyperstimulation syndrome.

Expert opinion on pharmacotherapy 20101001

Metformin action on AMP-activated protein kinase: a translational research approach to understanding a potential new therapeutic target.

Diabetic medicine : a journal of the British Diabetic Association 20101001

Using a PCT-wide electronic system called the Deadly Trio database to provide safety alerts about prescribing of metformin in renal disease.

Diabetic medicine : a journal of the British Diabetic Association 20101001

Effect of Metformin on mortality in patients with heart failure and type 2 diabetes mellitus.

The American journal of cardiology 20101001

Pharmacokinetic interaction between itraconazole and metformin in rats: competitive inhibition of metabolism of each drug by each other via hepatic and intestinal CYP3A1/2.

British journal of pharmacology 20101001

BI-10773, a sodium-glucose cotransporter 2 inhibitor for the potential oral treatment of type 2 diabetes mellitus.

Current opinion in investigational drugs (London, England : 2000) 20101001

Simultaneous determination of metformin, cimetidine, famotidine, and ranitidine in human serum and dosage formulations using HPLC with UV detection.

Journal of chromatographic science 20101001

Early clinical studies with liraglutide.

International journal of clinical practice. Supplement 20101001

Can acute overdose of metformin lead to lactic acidosis?

The American journal of emergency medicine 20101001

Pharmacokinetics of metformin after enteral administration in insulin-resistant ponies.

American journal of veterinary research 20101001

Initial short-term intensive insulin therapy as a strategy for evaluating the preservation of beta-cell function with oral antidiabetic medications: a pilot study with sitagliptin.

Diabetes, obesity & metabolism 20101001

Continuation versus discontinuation of insulin secretagogues when initiating insulin in type 2 diabetes.

Diabetes, obesity & metabolism 20101001

The relationship between the drug concentration profiles in plasma and the drug doses in the colon.

Chemical & pharmaceutical bulletin 20101001

Effects of metformin plus gliclazide compared with metformin alone on circulating endothelial progenitor cell in type 2 diabetic patients.

Endocrine 20101001

What are these lesions that spread from the lips. Fixed drug eruption.

JAAPA : official journal of the American Academy of Physician Assistants 20101001

Successful management of high-dose metformin intoxication. Role of vasopressin in the management of severe lactic acidosis.

Middle East journal of anaesthesiology 20101001

AID-induced genotoxic stress promotes B cell differentiation in the germinal center via ATM and LKB1 signaling.

Molecular cell 20100924

Metformin selectively attenuates mitochondrial H2O2 emission without affecting respiratory capacity in skeletal muscle of obese rats.

Free radical biology & medicine 20100915

Nickel oxide nanotubes-carbon microparticles/Nafion nanocomposite for the electrooxidation and sensitive detection of metformin.

Talanta 20100915

Metformin regulates breast cancer stem cell ontogeny by transcriptional regulation of the epithelial-mesenchymal transition (EMT) status.

Cell cycle (Georgetown, Tex.) 20100915

The importance of regulation of blood glucose levels through activation of peripheral 5'-AMP-activated protein kinase on ischemic neuronal damage.

Brain research 20100910

Intercourse compliance, ovulation, and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome (PPCOS) Trial.

Fertility and sterility 20100901

Letrozole versus combined metformin and clomiphene citrate for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a randomized controlled trial.

Fertility and sterility 20100901

Comparison of the effects of sibutramine versus sibutramine plus metformin in obese women.

Clinical and experimental medicine 20100901

Baseline serum total adiponectin level is positively associated with changes in bone mineral density after 1-year treatment of type 2 diabetes mellitus.

Metabolism: clinical and experimental 20100901

Effects of metformin administration on plasma gonadotropin levels in women with infertility, with an in vitro study of the direct effects on the pituitary gonadotrophs.

Pituitary 20100901

Effects of metformin and weight loss on serum alanine aminotransferase activity in the diabetes prevention program.

Obesity (Silver Spring, Md.) 20100901

Dietary energy availability affects primary and metastatic breast cancer and metformin efficacy.

Breast cancer research and treatment 20100901

Metformin inhibits aromatase expression in human breast adipose stromal cells via stimulation of AMP-activated protein kinase.

Breast cancer research and treatment 20100901

Coordinated maintenance of muscle cell size control by AMP-activated protein kinase.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20100901

Glucose-lowering therapies and cancer risk: the trials and tribulations of trials and observations.

Diabetologia 20100901

Experience of malignancies with oral glucose-lowering drugs in the randomised controlled ADOPT (A Diabetes Outcome Progression Trial) and RECORD (Rosiglitazone Evaluated for Cardiovascular Outcomes and Regulation of Glycaemia in Diabetes) clinical trials.

Diabetologia 20100901

Can postprandial blood glucose excursion be predicted in type 2 diabetes?

Diabetes care 20100901

Systematic care to reduce ethnic disparities in diabetes care.

Diabetes research and clinical practice 20100901

Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells.

International journal of radiation oncology, biology, physics 20100901

The role of serum lactate in the acute care setting.

Journal of intensive care medicine 20100901

Metformin administration restores allopregnanolone response to adrenocorticotropic hormone (ACTH) stimulation in overweight hyperinsulinemic patients with PCOS.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20100901

Metformin versus acarbose therapy in patients with polycystic ovary syndrome (PCOS): a prospective randomised double-blind study.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20100901

Hyperinsulinemia precedes insulin resistance in mice lacking pancreatic beta-cell leptin signaling.

Endocrinology 20100901

New strategies in pancreatic cancer: emerging epidemiologic and therapeutic concepts.

Clinical cancer research : an official journal of the American Association for Cancer Research 20100901

Sulphonylurea-metformin combination therapy, cardiovascular disease and all-cause mortality: the Fremantle Diabetes Study.

Diabetes, obesity & metabolism 20100901

Vildagliptin add-on to metformin produces similar efficacy and reduced hypoglycaemic risk compared with glimepiride, with no weight gain: results from a 2-year study.

Diabetes, obesity & metabolism 20100901

Metformin: taking away the candy for cancer?

European journal of cancer (Oxford, England : 1990) 20100901

Initial nonadherence, primary failure and therapeutic success of metformin monotherapy in clinical practice.

Current medical research and opinion 20100901

Metabolism and karyotype analysis of oocytes from patients with polycystic ovary syndrome.

Human reproduction (Oxford, England) 20100901

Lactic acidosis induced by metformin: incidence, management and prevention.

Drug safety 20100901

Dose-dependent effects of the once-daily GLP-1 receptor agonist lixisenatide in patients with Type 2 diabetes inadequately controlled with metformin: a randomized, double-blind, placebo-controlled trial.

Diabetic medicine : a journal of the British Diabetic Association 20100901

Impaired glucose tolerance and insulin resistance in heart failure: underrecognized and undertreated?

Journal of cardiac failure 20100901

Metformin suppresses colorectal aberrant crypt foci in a short-term clinical trial.

Cancer prevention research (Philadelphia, Pa.) 20100901

Metformin and other biguanides in oncology: advancing the research agenda.

Cancer prevention research (Philadelphia, Pa.) 20100901

Chemoprevention meets glucose control.

Cancer prevention research (Philadelphia, Pa.) 20100901

Metformin prevents tobacco carcinogen--induced lung tumorigenesis.

Cancer prevention research (Philadelphia, Pa.) 20100901

Metformin induced severe hypophosphatemia in a patient on hemodialysis.

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia 20100901

Distinguishing among incretin-based therapies. Glucose-lowering effects of incretin-based therapies.

The Journal of family practice 20100901

Distinguishing among incretin-based therapies. Safety, tolerability, and nonglycemic effects of incretin-based therapies.

The Journal of family practice 20100901

Distinguishing among incretin-based therapies. Patient education and self-management.

The Journal of family practice 20100901

Distinguishing among incretin-based therapies. Introduction.

The Journal of family practice 20100901

Distinguishing among incretin-based therapies. Pathophysiology of type 2 diabetes mellitus: potential role of incretin-based therapies.

The Journal of family practice 20100901

Metformin in polycystic ovary syndrome.

Annals of the New York Academy of Sciences 20100901

Effect of metformin taken in the 'fresh' in vitro fertilization/intracytoplasmic sperm injection cycle upon subsequent frozen embryo replacement in women with polycystic ovary syndrome.

Human fertility (Cambridge, England) 20100901

[Anti-cancer activity of metformin: new perspectives for an old drug].

Revue medicale suisse 20100901

Countering side effects.

Journal of psychiatric practice 20100901

The adjunctive use of metformin to treat or prevent atypical antipsychotic-induced weight gain: a review.

Journal of psychiatric practice 20100901

Benefits of self-monitoring blood glucose in the management of new-onset Type 2 diabetes mellitus: the St Carlos Study, a prospective randomized clinic-based interventional study with parallel groups.

Journal of diabetes 20100901

Top ways to reduce your risk of developing diabetes.

Mayo Clinic health letter (English ed.) 20100901

Effects of metformin and short-term lifestyle modification on the improvement of male hypogonadism associated with metabolic syndrome.

Minerva endocrinologica 20100901

The RCPE UK Consensus Statement on Diabetes.

The journal of the Royal College of Physicians of Edinburgh 20100901

Impact of 6 weeks of treatment with low-dose metformin and atorvastatin on glucose-induced changes of endothelial function in adults with newly diagnosed type 2 diabetes mellitus: A single-blind study.

Clinical therapeutics 20100901

Results of a model analysis of the cost-effectiveness of liraglutide versus exenatide added to metformin, glimepiride, or both for the treatment of type 2 diabetes in the United States.

Clinical therapeutics 20100901

Metformin-associated lactic acidosis (MALA): clinical profile and outcomes in patients admitted to the intensive care unit.

Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 20100901

[Clinical practice guidelines in type 2 diabetes mellitus: similarities and discrepancies].

Medicina clinica 20100901

[Reporting adverse reactions and events in randomised clinical trials].

Ugeskrift for laeger 20100830

Evaluation of consumer medication information dispensed in retail pharmacies.

Archives of internal medicine 20100809

Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomised trial.

Lancet (London, England) 20100807

Individualised incretin-based treatment for type 2 diabetes.

Lancet (London, England) 20100807

Glucose metabolism in burn patients: the role of insulin and other endocrine hormones.

Burns : journal of the International Society for Burn Injuries 20100801

Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells.

Breast cancer research and treatment 20100801

Metformin versus dietary treatment in nonalcoholic hepatic steatosis: a randomized study.

International journal of obesity (2005) 20100801

Metformin attenuates cardiac fibrosis by inhibiting the TGFbeta1-Smad3 signalling pathway.

Cardiovascular research 20100801

AMP-activated protein kinase (AMPK) activation regulates in vitro bone formation and bone mass.

Bone 20100801

Glucose-lowering agents and cancer mortality rates in type 2 diabetes: assessing effects of time-varying exposure.

Diabetologia 20100801

Effects of the peroxisome proliferator-activated receptor (PPAR)-gamma agonist pioglitazone on renal and hormonal responses to salt in diabetic and hypertensive individuals.

Diabetologia 20100801

AMP-activated protein kinase deficiency exacerbates aging-induced myocardial contractile dysfunction.

Aging cell 20100801

Number of circulating endothelial progenitor cells as a marker of vascular endothelial function for type 2 diabetes.

Vascular medicine (London, England) 20100801

Hypoglycemic symptoms in patients with type 2 diabetes in Asia-Pacific-Real-life effectiveness and care patterns of diabetes management: the RECAP-DM study.

Diabetes research and clinical practice 20100801

Metformin and cancer: licence to heal?

Expert opinion on investigational drugs 20100801

Metformin attenuates production of nitric oxide in response to lipopolysaccharide by inhibiting MyD88-independent pathway.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20100801

Evaluation of the potential for pharmacokinetic and pharmacodynamic interactions between dutogliptin, a novel DPP4 inhibitor, and metformin, in type 2 diabetic patients.

Current medical research and opinion 20100801

Nearly fatal metabolic acidosis: septic or toxic?

European journal of emergency medicine : official journal of the European Society for Emergency Medicine 20100801

A dose range finding study of novel oral insulin (IN-105) under fed conditions in type 2 diabetes mellitus subjects.

Diabetes, obesity & metabolism 20100801

Polymorphisms of the LEP- and LEPR genes, metabolic profile after prolonged clozapine administration and response to the antidiabetic metformin.

Schizophrenia research 20100801

Evaluation of a focal lesion in the liver. answer to the clinical challenges and images in GI question: image 3: Focal fatty infiltration.

Gastroenterology 20100801

Relationship between cumulative dose of thiazolidinediones and clinical outcomes in type 2 diabetic patients with history of heart failure: a population-based cohort study in Taiwan.

Pharmacoepidemiology and drug safety 20100801

Insulin pump therapy in patients with type 2 diabetes safely improved glycemic control using a simple insulin dosing regimen.

Diabetes technology & therapeutics 20100801

Cimetidine-induced lactic acidosis and acute pancreatitis.

Southern medical journal 20100801

[Rapid blood pH recovery in comatose patients with lactic acidosis is life saving].

Der Internist 20100801

Metformin and contrast media.

Radiology 20100801

Self-monitoring of blood glucose in tablet-treated type 2 diabetic patients (ZODIAC).

The Netherlands journal of medicine 20100801

Frequent reoccurrence of hypoglycemia in a type 2 diabetic patient with insulin antibodies.

Molecular diagnosis & therapy 20100801

Modern approach to metabolic rehabilitation of cancer patients: biguanides (phenformin and metformin) and beyond.

Future oncology (London, England) 20100801

[Effects of metformin on proliferation of human colon carcinoma cell line SW-480].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20100801

Metformin treatment for Type 2 diabetes in pregnancy?

Best practice & research. Clinical endocrinology & metabolism 20100801

Adding noninsulin antidiabetic drugs to metformin therapy for type 2 diabetes.

JAMA 20100728

Adding noninsulin antidiabetic drugs to metformin therapy for type 2 diabetes.

JAMA 20100728

Approval of chronic medication - Discovery Health hits new lows.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 20100727

[Vitamin B12 deficiency secondary to metformin therapy].

Medicina clinica 20100717

[Metformin and vitamin B12 deficiency].

Medicina clinica 20100717

Low-dose combination therapy with rosiglitazone and metformin to prevent type 2 diabetes mellitus (CANOE trial): a double-blind randomised controlled study.

Lancet (London, England) 20100710

Preventing type 2 diabetes with low-dose combinations.

Lancet (London, England) 20100710

Pioglitazone in addition to metformin improves erythrocyte deformability in patients with Type 2 diabetes mellitus.

Clinical science (London, England : 1979) 20100709

Protective effect of metformin in CD1 mice placed on a high carbohydrate-high fat diet.

Biochemical and biophysical research communications 20100702

Metformin overdose with a resultant serum pH of 6.59: survival without sequalae.

The Journal of emergency medicine 20100701

Three cases of severe metformin-related lactic acidosis.

European journal of anaesthesiology 20100701

Pioglitazone decreases plasma cholesteryl ester transfer protein mass, associated with a decrease in hepatic triglyceride content, in patients with type 2 diabetes.

Diabetes care 20100701

Effects of metformin on glucose metabolism of perfused rat livers.

Molecular and cellular biochemistry 20100701

Metformin suppresses hepatic gluconeogenesis and lowers fasting blood glucose levels through reactive nitrogen species in mice.

Diabetologia 20100701

A single nucleotide polymorphism in STK11 influences insulin sensitivity and metformin efficacy in hyperinsulinemic girls with androgen excess.

Diabetes care 20100701

Further improvement in postprandial glucose control with addition of exenatide or sitagliptin to combination therapy with insulin glargine and metformin: a proof-of-concept study.

Diabetes care 20100701

The oral dipeptidyl peptidase-4 inhibitor sitagliptin increases circulating endothelial progenitor cells in patients with type 2 diabetes: possible role of stromal-derived factor-1alpha.

Diabetes care 20100701

Prospects for new antimicrobials based on N,N-dimethylbiguanide complexes as effective agents on both planktonic and adhered microbial strains.

European journal of medicinal chemistry 20100701

Metformin, an antidiabetic agent, suppresses the production of tumor necrosis factor and tissue factor by inhibiting early growth response factor-1 expression in human monocytes in vitro.

The Journal of pharmacology and experimental therapeutics 20100701

Role of KLF15 in regulation of hepatic gluconeogenesis and metformin action.

Diabetes 20100701

N,N-dimethylbiguanide complexes displaying low cytotoxicity as potential large spectrum antimicrobial agents.

European journal of medicinal chemistry 20100701

The 11-beta-hydroxysteroid dehydrogenase type 1 inhibitor INCB13739 improves hyperglycemia in patients with type 2 diabetes inadequately controlled by metformin monotherapy.

Diabetes care 20100701

PCOSMIC: a multi-centre randomized trial in women with PolyCystic Ovary Syndrome evaluating Metformin for Infertility with Clomiphene.

Human reproduction (Oxford, England) 20100701

Patient-reported outcomes in patients with type 2 diabetes treated with liraglutide or glimepiride, both as add-on to metformin.

Primary care diabetes 20100701

Metformin: a therapeutic option for treating nonalcoholic fatty liver disease.

Digestive diseases and sciences 20100701

Metformin suppresses azoxymethane-induced colorectal aberrant crypt foci by activating AMP-activated protein kinase.

Molecular carcinogenesis 20100701

Pioglitazone versus metformin in two rat models of glucose intolerance and diabetes.

Pakistan journal of pharmaceutical sciences 20100701

An energetic tale of AMPK-independent effects of metformin.

The Journal of clinical investigation 20100701

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state.

The Journal of clinical investigation 20100701

Influence of metformin on GLUT1 gene and protein expression in rat streptozotocin diabetes mellitus model.

Archives of physiology and biochemistry 20100701

Metformin blocks migration and invasion of tumour cells by inhibition of matrix metalloproteinase-9 activation through a calcium and protein kinase Calpha-dependent pathway: phorbol-12-myristate-13-acetate-induced/extracellular signal-regulated kinase/activator protein-1.

British journal of pharmacology 20100701

Use of metformin in the treatment of polycystic ovary syndrome.

Women's health (London, England) 20100701

Analysis of metformin treatment for adolescent obesity at 48 rather than 24 weeks after treatment cessation.

Archives of pediatrics & adolescent medicine 20100701

Acute metformin overdose.

Annals of emergency medicine 20100701

Improving glycemic control and cardiometabolic risk through integrated treatment plans.

The Journal of the American Osteopathic Association 20100701

The increasing epidemiology of diabetes and review of current treatment algorithms.

The Journal of the American Osteopathic Association 20100701

Illustrative case and discussion: a 58-year-old man with diabetes.

The Journal of the American Osteopathic Association 20100701

Risks and benefits of attaining HbA(1c) goals: examining the evidence.

The Journal of the American Osteopathic Association 20100701

A single-center, open, comparative study of the effect of using self-monitoring of blood glucose to guide therapy on preclinical atherosclerotic markers in type 2 diabetic subjects.

Journal of diabetes science and technology 20100701

Influence of oral antidiabetic drugs on hyperglycemic response to foods in persons with type 2 diabetes mellitus as assessed by continuous glucose monitoring system: a pilot study.

Journal of diabetes science and technology 20100701

A retrospective cohort study of economic outcomes and adherence to monotherapy with metformin, pioglitazone, or a sulfonylurea among patients with type 2 diabetes mellitus in the United States from 2003 to 2005.

Clinical therapeutics 20100701

Comparison of the bioavailability and tolerability of fixed-dose combination glimepiride/metformin 2/500-mg tablets versus separate tablets: A single-dose, randomized-sequence, open-label, two-period crossover study in healthy Korean volunteers.

Clinical therapeutics 20100701

Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-controlled trial.

Lancet (London, England) 20100626

Effect of the anti-diabetic drug metformin on bone mass in ovariectomized rats.

European journal of pharmacology 20100610

Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation.

Cell metabolism 20100609

Comparative effects of telmisartan, sitagliptin and metformin alone or in combination on obesity, insulin resistance, and liver and pancreas remodelling in C57BL/6 mice fed on a very high-fat diet.

Clinical science (London, England : 1979) 20100608

An assessment of lifestyle modification versus medical treatment with clomiphene citrate, metformin, and clomiphene citrate-metformin in patients with polycystic ovary syndrome.

Fertility and sterility 20100601

AMPK agonists ameliorate sodium and fluid transport and inflammation in cystic fibrosis airway epithelial cells.

American journal of respiratory cell and molecular biology 20100601

Effects of sitagliptin or metformin added to pioglitazone monotherapy in poorly controlled type 2 diabetes mellitus patients.

Metabolism: clinical and experimental 20100601

Metformin regulates palmitate-induced apoptosis and ER stress response in HepG2 liver cells.

Immunopharmacology and immunotoxicology 20100601

Laparoscopic ovarian diathermy vs clomiphene citrate plus metformin as second-line strategy for infertile anovulatory patients with polycystic ovary syndrome: a randomized controlled trial.

American journal of obstetrics and gynecology 20100601

Metformin induces reductions in plasma cobalamin and haptocorrin bound cobalamin levels in elderly diabetic patients.

Clinical biochemistry 20100601

Novel assay of metformin levels in patients with type 2 diabetes and varying levels of renal function: clinical recommendations.

Diabetes care 20100601

Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase.

Endocrine-related cancer 20100601

Long-term metformin use is associated with decreased risk of breast cancer.

Diabetes care 20100601

Treatment of type 2 diabetes and outcomes in patients with heart failure: a nested case-control study from the U.K. General Practice Research Database.

Diabetes care 20100601

Epidemiological aspects of neoplasms in diabetes.

Acta diabetologica 20100601

Adjunct therapy for type 1 diabetes mellitus.

Nature reviews. Endocrinology 20100601

LC-MS/MS method using unbonded silica column and aqueous/methanol mobile phase for the simultaneous quantification of a drug candidate and co-administered metformin in rat plasma.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100601

Metformin provides weight reduction for hospitalized patients receiving polypharmacy.

Journal of clinical psychopharmacology 20100601

Metformin: safety in cardiac patients.

Postgraduate medical journal 20100601

Review: metformin: potential benefits and use in chronic kidney disease.

Nephrology (Carlton, Vic.) 20100601

Metformin-induced regulation of the intestinal D-glucose transporters.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20100601

[Comparison on efficacy and safety of two regimens for treatment of type 2 diabetes mellitus: glargine plus metformin versus neutral protamine hagedorn plus metformin].

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20100601

[Hypoglycemic therapy in heart disease patients with type 2 diabetes mellitus].

Giornale italiano di cardiologia (2006) 20100601

[Effect of metformin on the formation of hepatic fibrosis in type 2 diabetic rats].

Yao xue xue bao = Acta pharmaceutica Sinica 20100601

RCPE UK consensus statement on diabetes.

The journal of the Royal College of Physicians of Edinburgh 20100601

Development of directly compressible metformin hydrochloride by the spray-drying technique.

Acta pharmaceutica (Zagreb, Croatia) 20100601

Metformin reduces intracellular reactive oxygen species levels by upregulating expression of the antioxidant thioredoxin via the AMPK-FOXO3 pathway.

Biochemical and biophysical research communications 20100528

Reduced serum vitamin B-12 in patients taking metformin.

BMJ (Clinical research ed.) 20100520

[Treatment guidelines for hyperglycaemia in type 2 diabetes patients with stable chronic heart failure or ischemic cardiomyopathy without heart failure].

Medicina clinica 20100508

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner.

Cell metabolism 20100505

Metformin effects on ovarian ultrasound appearance and steroidogenic function in normal-weight normoinsulinemic women with polycystic ovary syndrome: a randomized double-blind placebo-controlled clinical trial.

Fertility and sterility 20100501

Acidosis in the hospital setting: is metformin a common precipitant?

Internal medicine journal 20100501

Effects of testosterone and metformin on glucose metabolism in endometrium.

Fertility and sterility 20100501

The cardiovascular effects of metformin: further reasons to consider an old drug as a cornerstone in the therapy of type 2 diabetes mellitus.

Current vascular pharmacology 20100501

The use of metformin in type 1 diabetes: a systematic review of efficacy.

Diabetologia 20100501

Effects of unsaturated fatty acids on progesterone secretion and selected protein kinases in goat granulosa cells.

Domestic animal endocrinology 20100501

Effects of exenatide plus rosiglitazone on beta-cell function and insulin sensitivity in subjects with type 2 diabetes on metformin.

Diabetes care 20100501

Clearance of the high intestinal (18)F-FDG uptake associated with metformin after stopping the drug.

European journal of nuclear medicine and molecular imaging 20100501

Pharmacokinetics of metformin during pregnancy.

Drug metabolism and disposition: the biological fate of chemicals 20100501

Assessing the cost-effectiveness of drug and lifestyle intervention following opportunistic screening for pre-diabetes in primary care.

Diabetologia 20100501

Metformin prevents experimental gentamicin-induced nephropathy by a mitochondria-dependent pathway.

Kidney international 20100501

Diabetes therapy and cancer risk: causal effects and other plausible explanations.

Diabetologia 20100501

Clinical evaluation of combined therapy for type 2 diabetes.

Current medical research and opinion 20100501

Metformin supplementation and life span in Fischer-344 rats.

The journals of gerontology. Series A, Biological sciences and medical sciences 20100501

Metformin and reduced risk of hepatocellular carcinoma in diabetic patients with chronic liver disease.

Liver international : official journal of the International Association for the Study of the Liver 20100501

[Revascularization in patients with type 2 diabetes and coronary artery disease: BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) Study Group].

Der Internist 20100501

Crosstalk between insulin/insulin-like growth factor-1 receptors and G protein-coupled receptor signaling systems: a novel target for the antidiabetic drug metformin in pancreatic cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research 20100501

The lysosome among targets of metformin: new anti-inflammatory uses for an old drug?

Expert opinion on therapeutic targets 20100501

Diabetes: preventing type 2 diabetes mellitus: is metformin the answer?

Nature reviews. Endocrinology 20100501

Understanding the inter-relationship between improved glycaemic control, hypoglycaemia and weight change within a long-term economic model.

Diabetes, obesity & metabolism 20100501

Adding insulin glargine vs. NPH insulin to metformin results in a more efficient postprandial beta-cell protection in individuals with type 2 diabetes.

Diabetes, obesity & metabolism 20100501

Efficacy and safety of sitagliptin and metformin as initial combination therapy and as monotherapy over 2 years in patients with type 2 diabetes.

Diabetes, obesity & metabolism 20100501

[Sequential treatment with insulin glargine and metformin, and exenatide in a patient with newly diagnosed type-2 diabetes].

Deutsche medizinische Wochenschrift (1946) 20100501

Amelioration of aminoglycoside nephrotoxicity requires protection of renal mitochondria.

Kidney international 20100501

Metformin in cancer therapy: a new perspective for an old antidiabetic drug?

Molecular cancer therapeutics 20100501

Effective switch from premixed to basal-prandial insulin to achieve glycemic goals in type 2 diabetes.

Postgraduate medicine 20100501

Obesity, hyperinsulinemia and breast cancer: novel targets and a novel role for metformin.

Expert review of molecular diagnostics 20100501

Everything old is new again: spironolactone and metformin in the treatment of acne.

Journal of drugs in dermatology : JDD 20100501

[Indication of metformin in the management of hormonal dysfunction secondary to polycystic ovarian syndrome: prospective comparative study of 63 cases].

La Tunisie medicale 20100501

Calorie restriction: what recent results suggest for the future of ageing research.

European journal of clinical investigation 20100501

Type 2 diabetes and cardiovascular disease in polycystic ovary syndrome: what are the risks and can they be reduced?

Diabetic medicine : a journal of the British Diabetic Association 20100501

Safety and tolerability of high doses of taspoglutide, a once-weekly human GLP-1 analogue, in diabetic patients treated with metformin: a randomized double-blind placebo-controlled study.

Diabetic medicine : a journal of the British Diabetic Association 20100501

Incorporating practical lifestyle management for obesity.

The Journal of family practice 20100501

Diabetes drug interferes with vitamin B12.

Harvard heart letter : from Harvard Medical School 20100501

Effect of Cyclea peltata Lam. roots aqueous extract on glucose levels, lipid profile, insulin, TNF-alpha and skeletal muscle glycogen in type 2 diabetic rats.

Indian journal of experimental biology 20100501

Addition of incretin therapy to metformin in type 2 diabetes.

Lancet (London, England) 20100424

Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomised, parallel-group, open-label trial.

Lancet (London, England) 20100424

Hypoglycemic effects of Cecropia pachystachya in normal and alloxan-induced diabetic rats.

Journal of ethnopharmacology 20100421

Association of diabetes duration and diabetes treatment with the risk of hepatocellular carcinoma.

Cancer 20100415

Effect of noninsulin antidiabetic drugs added to metformin therapy on glycemic control, weight gain, and hypoglycemia in type 2 diabetes.

JAMA 20100414

Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.

The Cochrane database of systematic reviews 20100414

[Diagnosis and treatment of polycystic ovary syndrome].

Orvosi hetilap 20100404

Atorvastatin pretreatment augments the effect of metformin in patients with polycystic ovary syndrome (PCOS).

Clinical endocrinology 20100401

Novel inflammatory markers in overweight women with and without polycystic ovary syndrome and following pharmacological intervention.

Journal of endocrinological investigation 20100401

Metformin regresses endometriotic implants in rats by improving implant levels of superoxide dismutase, vascular endothelial growth factor, tissue inhibitor of metalloproteinase-2, and matrix metalloproteinase-9.

American journal of obstetrics and gynecology 20100401

Combination therapy with sulfonylureas and metformin and the prevention of death in type 2 diabetes: a nested case-control study.

Pharmacoepidemiology and drug safety 20100401

Sulphonyurea as a cause of severe hypoglycaemia in the community.

Primary care diabetes 20100401

Potent and specific inhibition of mMate1-mediated efflux of type I organic cations in the liver and kidney by pyrimethamine.

The Journal of pharmacology and experimental therapeutics 20100401

Changes in prandial glucagon levels after a 2-year treatment with vildagliptin or glimepiride in patients with type 2 diabetes inadequately controlled with metformin monotherapy.

Diabetes care 20100401

Increased glycation and oxidative damage to apolipoprotein B100 of LDL cholesterol in patients with type 2 diabetes and effect of metformin.

Diabetes 20100401

Metformin normalizes type 2 diabetes-induced decrease in cell proliferation and neuroblast differentiation in the rat dentate gyrus.

Neurochemical research 20100401

Combining short-term metformin treatment and one bout of exercise does not increase insulin action in insulin-resistant individuals.

American journal of physiology. Endocrinology and metabolism 20100401

Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5.

The Journal of endocrinology 20100401

Genetic deletion or pharmacological inhibition of dipeptidyl peptidase-4 improves cardiovascular outcomes after myocardial infarction in mice.

Diabetes 20100401

Systemic and local effects of metformin administration in patients with polycystic ovary syndrome (PCOS): relationship to the ovulatory response.

Human reproduction (Oxford, England) 20100401

[An approach to adopt in patients with metformin-associated vitamin B12 deficiency].

Atencion primaria 20100401

Metformin reverses hexokinase and 6-phosphofructo-1-kinase inhibition in skeletal muscle, liver and adipose tissues from streptozotocin-induced diabetic mouse.

Archives of biochemistry and biophysics 20100401

The effects of metformin and letrozole on endometriosis and comparison of the two treatment agents in a rat model.

Human reproduction (Oxford, England) 20100401

Dehydroepiandrosterone to induce murine models for the study of polycystic ovary syndrome.

The Journal of steroid biochemistry and molecular biology 20100401

Diabetes medications related to an increased risk of falls and fall-related morbidity in the elderly.

The Annals of pharmacotherapy 20100401

Insulin sensitiser agents alone and in co-treatment with r-FSH for ovulation induction in PCOS women.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20100401

Efficacy of metformin and topiramate in prevention and treatment of second-generation antipsychotic-induced weight gain.

The Annals of pharmacotherapy 20100401

Role of human placental apical membrane transporters in the efflux of glyburide, rosiglitazone, and metformin.

American journal of obstetrics and gynecology 20100401

Twelve weeks treatment with the DPP-4 inhibitor, sitagliptin, prevents degradation of peptide YY and improves glucose and non-glucose induced insulin secretion in patients with type 2 diabetes mellitus.

Diabetes, obesity & metabolism 20100401

Metformin induces glucose uptake in human preadipocyte-derived adipocytes from various fat depots.

Diabetes, obesity & metabolism 20100401

Use of metformin to control clozapine-associated weight gain in an adolescent with schizoaffective disorder.

Journal of child and adolescent psychopharmacology 20100401

Insulin, insulin resistance, obesity, and cancer.

Current diabetes reports 20100401

Hirsutism: Diagnosis and management.

Gender medicine 20100401

The impact of publishing medical specialty society guidelines on subsequent adoption of best practices: a case study with type 2 diabetes.

International journal of clinical practice 20100401

Safety and efficacy of treatment with sitagliptin or glipizide in patients with type 2 diabetes inadequately controlled on metformin: a 2-year study.

International journal of clinical practice 20100401

Biopharmaceutical evaluation of formulated metformin/rosiglitazone tablets.

Drug discoveries & therapeutics 20100401

Life threatening lactic acidosis.

BMJ (Clinical research ed.) 20100324

Toxicity and toxicokinetics of metformin in rats.

Toxicology and applied pharmacology 20100315

Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells.

Cancer research 20100315

Metformin: a therapeutic opportunity in breast cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research 20100315

Metformin and cancer: doses, mechanisms and the dandelion and hormetic phenomena.

Cell cycle (Georgetown, Tex.) 20100315

Intracellular succinylation of 8-chloroadenosine and its effect on fumarate levels.

The Journal of biological chemistry 20100312

Insulin regimens in type 2 diabetes.

The New England journal of medicine 20100311

Insulin regimens in type 2 diabetes.

The New England journal of medicine 20100311

[Discharge letter with therapeutic recommendations: you have to sort out!].

MMW Fortschritte der Medizin 20100311

Metformin induces suppression of NAD(P)H oxidase activity in podocytes.

Biochemical and biophysical research communications 20100305

Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation.

Cell metabolism 20100303

Effect of rimonabant and metformin on glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 in obese women with polycystic ovary syndrome.

Clinical endocrinology 20100301

[Vitamin B12 deficiency in patients treated with metformin: an approach to adopt].

Atencion primaria 20100301

Effects of rosiglitazone and metformin treatment on apelin, visfatin, and ghrelin levels in patients with type 2 diabetes mellitus.

Metabolism: clinical and experimental 20100301

Drug release and its relationship with kinetic and thermodynamic parameters of drug sorption onto starch acetate fibers.

Biotechnology and bioengineering 20100301

Endoplasmic reticulum stress involved in the course of lipogenesis in fatty acids-induced hepatic steatosis.

Journal of gastroenterology and hepatology 20100301

Acute rhabdomyolysis during treatment with amisulpride and metformin.

European journal of clinical pharmacology 20100301

Metformin influence on hormone levels at birth, in PCOS mothers and their newborns.

Human reproduction (Oxford, England) 20100301

Pharmacokinetic interaction between telithromycin and metformin in diabetes mellitus rats.

Xenobiotica; the fate of foreign compounds in biological systems 20100301

Secondary failure of metformin monotherapy in clinical practice.

Diabetes care 20100301

Variability and impact on design of bioequivalence studies.

Basic & clinical pharmacology & toxicology 20100301

Metformin inhibits inflammatory angiogenesis in a murine sponge model.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20100301

Efficacy and safety of monotherapy of sitagliptin compared with metformin in patients with type 2 diabetes.

Diabetes, obesity & metabolism 20100301

Serum galectin-3 is elevated in obesity and negatively correlates with glycosylated hemoglobin in type 2 diabetes.

The Journal of clinical endocrinology and metabolism 20100301

Could oral hypoglycemics be the new therapeutic answer to chronic obstructive pulmonary disease?

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 20100301

Metformin-induced vitamin B12 deficiency presenting as a peripheral neuropathy.

Southern medical journal 20100301

Clinical, metabolic, and endocrine parameters in response to metformin and lifestyle intervention in women with polycystic ovary syndrome: a randomized, double-blind, and placebo control trial.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20100301

Titration of inhaled human insulin (Exubera) in a treat-to-target regimen for patients with type 2 diabetes.

Diabetes technology & therapeutics 20100301

Exenatide versus glibenclamide in patients with diabetes.

Diabetes technology & therapeutics 20100301

Metformin for atypical antipsychotic-induced weight gain and glucose metabolism dysregulation: review of the literature and clinical suggestions.

CNS drugs 20100301

Association between vitamin B12 levels and mortality in hospitalized older adults.

Journal of the American Geriatrics Society 20100301

Diabetes: Strategies to prevent the type 2 diabetes mellitus epidemic.

Nature reviews. Endocrinology 20100301

The effect of metformin on alveolar bone in ligature-induced periodontitis in rats: a pilot study.

Journal of periodontology 20100301

Metformin improves sustained virologic response in difficult-to-cure hepatitis C: more questions than answers.

Hepatology (Baltimore, Md.) 20100301

Impact of metformin-induced gastrointestinal symptoms on quality of life and adherence in patients with type 2 diabetes.

Postgraduate medicine 20100301

Metformin therapy and outcomes in patients with advanced systolic heart failure and diabetes.

Journal of cardiac failure 20100301

Metformin use in patients with diabetes mellitus and heart failure: friend or foe?

Journal of cardiac failure 20100301

Severe metabolic acidosis secondary to coadministration of creatine and metformin, a case report.

The American journal of emergency medicine 20100301

Glucose supply and insulin demand dynamics of antidiabetic agents.

Journal of diabetes science and technology 20100301

[GLP-1: a new therapeutic principle for the treatment of type 2 diabetes mellitus].

Medizinische Klinik (Munich, Germany : 1983) 20100301

New therapeutic options: management strategies to optimize glycemic control.

The Journal of the American Osteopathic Association 20100301

[Sugar: results of a Belgian observational study on the use of sitagliptin in patients with type 2 diabetes].

Revue medicale de Liege 20100301

Tectone, a new antihyperglycemic anthraquinone from Tectona grandis leaves.

Natural product communications 20100301

Comparison of metformin, gliclazide MR and rosiglitazone in monotherapy and in combination for type 2 diabetes.

Arquivos brasileiros de endocrinologia e metabologia 20100301

A comparison of efficacy and safety of vildagliptin and gliclazide in combination with metformin in patients with Type 2 diabetes inadequately controlled with metformin alone: a 52-week, randomized study.

Diabetic medicine : a journal of the British Diabetic Association 20100301

Thailand Diabetic Registry cohort: predicting death in Thai diabetic patients and causes of death.

Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20100301

Metformin reduces lipid accumulation in macrophages by inhibiting FOXO1-mediated transcription of fatty acid-binding protein 4.

Biochemical and biophysical research communications 20100226

Metformin stinks, literally.

Annals of internal medicine 20100216

Enhancement of muscle cell glucose uptake by medicinal plant species of Canada's native populations is mediated by a common, metformin-like mechanism.

Journal of ethnopharmacology 20100203

Effect of metformin on serum visfatin levels in patients with polycystic ovary syndrome.

Fertility and sterility 20100201

Metformin therapy to reduce weight gain and visceral adiposity in children and adolescents with neurogenic or myogenic motor deficit.

Pediatric diabetes 20100201

Gastroprotective effects of the insulin sensitizers rosiglitazone and metformin against indomethacin-induced gastric ulcers in Type 2 diabetic rats.

Clinical and experimental pharmacology & physiology 20100201

Effect of metformin on bone marrow progenitor cell differentiation: in vivo and in vitro studies.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20100201

Intraperitoneal fat and insulin resistance in obese adolescents.

Obesity (Silver Spring, Md.) 20100201

Improvement in quality-of-life questionnaire measures in obese adolescent females with polycystic ovary syndrome treated with lifestyle changes and oral contraceptives, with or without metformin.

Fertility and sterility 20100201

Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression.

Metabolism: clinical and experimental 20100201

Metformin: an old medication of new fashion: evolving new molecular mechanisms and clinical implications in polycystic ovary syndrome.

European journal of endocrinology 20100201

AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC.

American journal of physiology. Endocrinology and metabolism 20100201

Metformin versus laparoscopic ovarian drilling in clomiphene- and insulin-resistant women with polycystic ovary syndrome.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20100201

Metformin decreases IGF1-induced cell proliferation and protein synthesis through AMP-activated protein kinase in cultured bovine granulosa cells.

Reproduction (Cambridge, England) 20100201

Metformin associated with lower cancer mortality in type 2 diabetes: ZODIAC-16.

Diabetes care 20100201

Metformin in chronic hepatitis C virus hepatitis: caution needed with sex-based subgroup analysis.

Hepatology (Baltimore, Md.) 20100201

Effects of metformin with or without supplementation with folate on homocysteine levels and vascular endothelium of women with polycystic ovary syndrome.

Diabetes care 20100201

Evaluation of a simple policy for pre- and post-prandial blood glucose self-monitoring in people with type 2 diabetes not on insulin.

Diabetes research and clinical practice 20100201

Metformin reduces arterial stiffness and improves endothelial function in young women with polycystic ovary syndrome: a randomized, placebo-controlled, crossover trial.

The Journal of clinical endocrinology and metabolism 20100201

Metformin increases phagocytosis and acidifies lysosomal/endosomal compartments in AMPK-dependent manner in rat primary microglia.

Naunyn-Schmiedeberg's archives of pharmacology 20100201

Heterozygous variants of multidrug and toxin extrusions (MATE1 and MATE2-K) have little influence on the disposition of metformin in diabetic patients.

Pharmacogenetics and genomics 20100201

Androgen excess in women: not just a cosmetic problem.

Annales d'endocrinologie 20100201

Should physicians prescribe metformin to women with polycystic ovary syndrome PCOS?

Annales d'endocrinologie 20100201

Efficacy and safety of sitagliptin when added to insulin therapy in patients with type 2 diabetes.

Diabetes, obesity & metabolism 20100201

Reproductive endocrinology: live birth prediction in polycystic ovary syndrome.

Nature reviews. Endocrinology 20100201

Effects of oral contraceptives and metformin on the outcome of in vitro maturation in infertile women with polycystic ovary syndrome.

Journal of women's health (2002) 20100201

Metformin extended release treatment of adolescent obesity: a 48-week randomized, double-blind, placebo-controlled trial with 48-week follow-up.

Archives of pediatrics & adolescent medicine 20100201

SLC22A2 gene 808 G/T variant is related to plasma lactate concentration in Chinese type 2 diabetics treated with metformin.

Acta pharmacologica Sinica 20100201

Best methods for identification and treatment of PCOS.

Minerva ginecologica 20100201

Metformin's effect on exercise and postexercise substrate oxidation.

International journal of sport nutrition and exercise metabolism 20100201

Optimization of a metformin effervescent floating tablet containing hydroxypropylmethylcellulose and stearic acid.

Die Pharmazie 20100201

Transitory activation of AMPK at reperfusion protects the ischaemic-reperfused rat myocardium against infarction.

Cardiovascular drugs and therapy 20100201

Efficacy of metformin in the treatment of diabetes mellitus complicating thalassemia major.

La Tunisie medicale 20100201

Low-abundant adiponectin receptors in visceral adipose tissue of humans and rats are further reduced in diabetic animals.

Archives of medical research 20100201

Effect of metformin on renal microsomal proteins, lipid peroxidation and antioxidant status in dexamethasone-induced type-2 diabetic mice.

Indian journal of biochemistry & biophysics 20100201

Slower clearance of intravenous metformin in rats with acute renal failure induced by uranyl nitrate: contribution of slower renal and non-renal clearances.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20100131

The role of organic cation transporters (OCTs) in the transfer of metformin in the dually perfused human placenta.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20100131

Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.

The Cochrane database of systematic reviews 20100120

Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility.

The Cochrane database of systematic reviews 20100120

Metformin, B(12), and enhanced breast cancer response to chemotherapy.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100110

Endothelial function and insulin resistance in polycystic ovary syndrome: the effects of medical therapy.

Fertility and sterility 20100101

Effects of vildagliptin twice daily vs. sitagliptin once daily on 24-hour acute glucose fluctuations.

Journal of diabetes and its complications 20100101

Comparison of four different treatment regimens on coagulation parameters, hormonal and metabolic changes in women with polycystic ovary syndrome.

Archives of gynecology and obstetrics 20100101

The MALAdy of metformin poisoning: Is CVVH the cure?

American journal of therapeutics 20100101

Weight loss, HbA1c reduction, and tolerability of cetilistat in a randomized, placebo-controlled phase 2 trial in obese diabetics: comparison with orlistat (Xenical).

Obesity (Silver Spring, Md.) 20100101

The role of hyperglycemia in burned patients: evidence-based studies.

Shock (Augusta, Ga.) 20100101

Metformin: safety in cardiac patients.

Heart (British Cardiac Society) 20100101

Pioglitazone, but not metformin, reduces liver fat in Type-2 diabetes mellitus independent of weight changes.

Journal of diabetes and its complications 20100101

Metformin reverses the deleterious effects of high glucose on osteoblast function.

Journal of diabetes and its complications 20100101

Efficacy of insulin-sensitizing agents in nonalcoholic fatty liver disease.

European journal of gastroenterology & hepatology 20100101

Treatment of nonalcoholic fatty liver disease in children: TONIC trial design.

Contemporary clinical trials 20100101

The role of family history in clinical symptoms and therapeutic outcomes of women with polycystic ovary syndrome.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20100101

Pubertal metformin therapy to reduce total, visceral, and hepatic adiposity.

The Journal of pediatrics 20100101

Effects of colesevelam, rosiglitazone, or sitagliptin on glycemic control and lipid profile in patients with type 2 diabetes mellitus inadequately controlled by metformin monotherapy.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20100101

Rosiglitazone decreases C-reactive protein to a greater extent relative to glyburide and metformin over 4 years despite greater weight gain: observations from a Diabetes Outcome Progression Trial (ADOPT).

Diabetes care 20100101

Many Americans have pre-diabetes and should be considered for metformin therapy.

Diabetes care 20100101

Metformin is a potent inhibitor of endometrial cancer cell proliferation--implications for a novel treatment strategy.

Gynecologic oncology 20100101

High-throughput assay for modulators of mitochondrial membrane potential identifies a novel compound with beneficial effects on db/db mice.

Diabetes 20100101

Glycemia and its relationship to outcomes in the metformin in gestational diabetes trial.

Diabetes care 20100101

Association of metformin, elevated homocysteine, and methylmalonic acid levels and clinically worsened diabetic peripheral neuropathy.

Diabetes care 20100101

Effect of rosiglitazone, metformin, and glyburide on bone biomarkers in patients with type 2 diabetes.

The Journal of clinical endocrinology and metabolism 20100101

Incorporating the antidiabetic drug metformin in HER2-positive breast cancer treated with neo-adjuvant chemotherapy and trastuzumab: an ongoing clinical-translational research experience at the Catalan Institute of Oncology.

Annals of oncology : official journal of the European Society for Medical Oncology 20100101

Interaction between polymorphisms in the OCT1 and MATE1 transporter and metformin response.

Pharmacogenetics and genomics 20100101

Pioglitazone compared with metformin increases pericardial fat volume in patients with type 2 diabetes mellitus.

The Journal of clinical endocrinology and metabolism 20100101

Metformin extends life span of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo.

Cell cycle (Georgetown, Tex.) 20100101

Metformin compared with glyburide in gestational diabetes: a randomized controlled trial.

Obstetrics and gynecology 20100101

Continuation of metformin reduces early pregnancy loss in obese Pakistani women with polycystic ovarian syndrome.

Gynecologic and obstetric investigation 20100101

The art and science of medical guidelines: what we know and what we believe.

Radiology 20100101

Systematic review of current guidelines, and their evidence base, on risk of lactic acidosis after administration of contrast medium for patients receiving metformin.

Radiology 20100101

Pharmacokinetics of alogliptin when administered with food, metformin, or cimetidine: a two-phase, crossover study in healthy subjects.

International journal of clinical pharmacology and therapeutics 20100101

Nutrition-related vitamin B12 deficiency in patients in Pakistan with type 2 diabetes mellitus not taking metformin.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20100101

Quantitative spot-test analysis of metformin in pharmaceutical preparations using ultraviolet-visible diffuse reflectance spectroscopy.

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20100101

Effect of meglitinides on postprandial ghrelin secretion pattern in type 2 diabetes mellitus.

Diabetes technology & therapeutics 20100101

Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1.

PloS one 20100101

Evaluation of efficacy and tolerability of gliclazide and metformin combination: a multicentric study in patients with type 2 diabetes mellitus uncontrolled on monotherapy with sulfonylurea or metformin.

American journal of therapeutics 20100101

Reaching HbA1c goals with saxagliptin in combination with other oral antidiabetic drugs.

Postgraduate medicine 20100101

Managing highly insulin-resistant diabetes mellitus: weight loss approaches and medical management.

Postgraduate medicine 20100101

Metabolic regulation of neuronal plasticity by the energy sensor AMPK.

PloS one 20100101

Hemoglobin A1c for the diagnosis of diabetes: practical considerations.

Polskie Archiwum Medycyny Wewnetrznej 20100101

Effect of pioglitazone on various parameters of insulin resistance including lipoprotein subclass according to particle size by a gel-permeation high-performance liquid chromatography in newly diagnosed patients with type 2 diabetes.

Endocrine journal 20100101

Oxygen consumption is depressed in patients with lactic acidosis due to biguanide intoxication.

Critical care (London, England) 20100101

Epidemiology, assessment, and management of excess abdominal fat in persons with HIV infection.

AIDS reviews 20100101

Relationship between drug release and some physical parameters of drug sorption onto PLA fibers.

Journal of biomaterials science. Polymer edition 20100101

Metformin treatment of diabetes mellitus increases the risk for pancreatitis in patients bearing the CFTR-mutation S573C.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101

Determination of metformin hydrochloride and glyburide in an antihyperglycemic binary mixture using high-performance liquid chromatographic-UV and spectrometric methods.

Journal of AOAC International 20100101

Improved glycemic control with insulin glargine versus pioglitazone as add-on therapy to sulfonylurea or metformin in patients with uncontrolled type 2 diabetes mellitus.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20100101

[Antihypertensive effect of metformin in essential hypertensive patients with hyperinsulinemia.].

Zhonghua nei ke za zhi 20100101

The BARI 2D study: a randomised trial of therapies for type 2 diabetes and coronary artery disease.

Diabetes & vascular disease research 20100101

Pre-existing cardiovascular diseases and glycemic control in patients with type 2 diabetes mellitus in Europe: a matched cohort study.

Cardiovascular diabetology 20100101

Excretion of estrogens, catecholestrogens and phytoestrogens in carriers of BRCA1 gene mutations: effects of metformin.

Neoplasma 20100101

Clarifying metformin's role and risks in liver dysfunction.

Journal of the American Pharmacists Association : JAPhA 20100101

FGFR3 mutations and the skin: report of a patient with a FGFR3 gene mutation, acanthosis nigricans, hypochondroplasia and hyperinsulinemia and review of the literature.

Dermatology (Basel, Switzerland) 20100101

Insulin resistance and response to antiviral therapy in chronic hepatitis C: mechanisms and management.

Digestive diseases (Basel, Switzerland) 20100101

Pregnancy outcome in women with polycystic ovary syndrome comparing the effects of laparoscopic ovarian drilling and clomiphene citrate stimulation in women pre-treated with metformin: a retrospective study.

Reproductive biology and endocrinology : RB&E 20100101

Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial.

BMJ (Clinical research ed.) 20100101

A new look at established therapies: practical tools for optimizing insulin use.

The Diabetes educator 20100101

Probable hypoglycemic adverse drug reaction associated with prickly pear cactus, glipizide, and metformin in a patient with type 2 diabetes mellitus.

The Annals of pharmacotherapy 20100101

The vitamin E reduces liver lipoperoxidation and fibrosis in a model of nonalcoholic steatohepatitis.

Arquivos de gastroenterologia 20100101

Metformin reduces body weight gain and improves glucose intolerance in high-fat diet-fed C57BL/6J mice.

Biological & pharmaceutical bulletin 20100101

Links between granuloma annulare, necrobiosis lipoidica diabeticorum and childhood diabetes: a matter of time?

Pediatric dermatology 20100101

Saxagliptin: a new dipeptidyl peptidase-4 inhibitor for type 2 diabetes.

Cardiology in review 20100101

[Lipid profile in obese and non-obese women with polycystic ovary syndrome treated with metformin].

Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion 20100101

Diabetes and cancer: a consensus report.

CA: a cancer journal for clinicians 20100101

Comparison of pioglitazone vs glyburide in early heart failure: insights from a randomized controlled study of patients with type 2 diabetes and mild cardiac disease.

Congestive heart failure (Greenwich, Conn.) 20100101

Antioxidant protective effect of glibenclamide and metformin in combination with honey in pancreas of streptozotocin-induced diabetic rats.

International journal of molecular sciences 20100101

The efficacy and safety of insulin-sensitizing drugs in HIV-associated lipodystrophy syndrome: a meta-analysis of randomized trials.

BMC infectious diseases 20100101

What your doctor is reading.

Diabetes self-management 20100101

Cost effectiveness of insulin glargine plus oral antidiabetes drugs compared with premixed insulin alone in patients with type 2 diabetes mellitus in Canada.

Applied health economics and health policy 20100101

Comment: Efficacy of metformin and topiramate in prevention and treatment of second-generation antipsychotic-induced weight gain.

The Annals of pharmacotherapy 20100101

[Mechanism of inhibition of hepatic glucose production by metformin: a new concept for an old remedy].

Medecine sciences : M/S 20100101

Initial combination therapy with metformin and colesevelam for achievement of glycemic and lipid goals in early type 2 diabetes.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20100101

Preliminary data on effects of metformin on PED/PEA-15 cellular levels in obese women with polycystic ovary syndrome.

Journal of endocrinological investigation 20100101

Low-dose metformin improves pregnancy rate in in vitro fertilization repeaters without polycystic ovary syndrome: prediction of effectiveness by multiple parameters related to insulin resistance.

Hormones (Athens, Greece) 20100101

How much do you know about metformin?

Diabetes self-management 20100101

An economic evaluation of colesevelam when added to metformin-, insulin- or sulfonylurea-based therapies in patients with uncontrolled type 2 diabetes mellitus.

PharmacoEconomics 20100101

[Effect of previous diabetes therapy on tumor receptor phenotype in breast cancer: comparison of metformin and sulphonylurea derivatives].

Voprosy onkologii 20100101

Increased expression of hepatic organic cation transporter 1 and hepatic distribution of metformin in high-fat diet-induced obese mice.

Drug metabolism and pharmacokinetics 20100101

Effects of metformin on rosiglitazone-induced cardiac hypertrophy in mice.

Biological & pharmaceutical bulletin 20100101

Management of diabetes mellitus in Cushing's syndrome.

Neuroendocrinology 20100101

[Dynamics of structural-functional parameters of cardiovascular system during use of complex therapy of women with type 2 diabetes mellitus].

Kardiologiia 20100101

A systems biology approach to identify effective cocktail drugs.

BMC systems biology 20100101

Diabetes treatment patterns and goal achievement in primary diabetes care (DiaRegis) - study protocol and patient characteristics at baseline.

Cardiovascular diabetology 20100101

Metabolic engineering of resveratrol and other longevity boosting compounds.

BioFactors (Oxford, England) 20100101

Life span extension by resveratrol, rapamycin, and metformin: The promise of dietary restriction mimetics for an healthy aging.

BioFactors (Oxford, England) 20100101

[Capabilities of hypoglycemic therapy in women with decompensated type 2 diabetes mellitus].

Terapevticheskii arkhiv 20100101

Bioequivalence of sitagliptin/metformin fixed-dose combination tablets and concomitant administration of sitagliptin and metformin in healthy adult subjects: a randomized, open-label, crossover study.

Clinical drug investigation 20100101

Clinical outcomes of ovulation induction with metformin, clomiphene citrate and human menopausal gonadotrophin in polycystic ovary syndrome.

The Journal of international medical research 20100101

[Sonographic ovarian vascularization and volume in women with polycystic ovary syndrome treated with clomiphene citrate and metformin].

Ginecologia y obstetricia de Mexico 20100101

Persistence patterns with oral antidiabetes drug treatment in newly treated patients--a population-based study.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20100101

Metformin has adenosine-monophosphate activated protein kinase (AMPK)-independent effects on LPS-stimulated rat primary microglial cultures.

Pharmacological reports : PR 20100101

Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide.

Pharmacological reports : PR 20100101

Activation of the AMP-activated protein kinase enhances glucose-stimulated insulin secretion in mouse β-cells.

Islets 20100101

Justification of metformin hydrochloride biowaiver criteria based on bioequivalence study.

Arzneimittel-Forschung 20100101

Metformin: 'Old warrior for a new battle'.

Indian journal of cancer 20100101

[Melatonin and metformin inhibit skin carcinogenesis induced by benz(a)pyrene in mice].

Voprosy onkologii 20100101

Teaching an old drug new tricks: metformin as a targeted therapy for lung cancer.

Seminars in thoracic and cardiovascular surgery 20100101

Outcome of severe lactic acidosis associated with metformin accumulation.

Critical care (London, England) 20100101

Determination of impurities in medical products containing metformin hydrochloride.

Acta poloniae pharmaceutica 20100101

Optimization and validation of an RP-HPLC method for direct determination of metformin hydrochloride in human urine and in a dosage form.

Journal of AOAC International 20100101

Part D coverage gap and adherence to diabetes medications.

The American journal of managed care 20100101

[Influence of metformin and N-acetylcysteine on hormonal and genotoxic effects of estrogens and glucose in convalescent cancer patients].

Voprosy onkologii 20100101

[The effects of metformin plus sulfonylurea therapy on clinical features of the metabolic syndrome].

Medicinski pregled 20100101

Perioperative use of metformin in cardiac surgery.

Medicina (Kaunas, Lithuania) 20100101

Determination of metformin in human plasma and urine by high-performance liquid chromatography using small sample volume and conventional octadecyl silane column.

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20100101

[Formulation by design of experiments of immediate release tablets with metformin hydrochloride and glibenclamide].

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20100101

[Efficacy of short-term metformin application in complex treatment of patients with coronary artery disease and concomitant metabolic syndrome].

Likars'ka sprava 20100101

[Efficacy of complex therapy with metformin and ramipril combination for patients with metabolic syndrome].

Likars'ka sprava 20100101

Metformin and lactic acidosis. NSAIDs and renin-angiotensin-aldosterone system.

BMJ (Clinical research ed.) 20091223

Metformin and lactic acidosis. Metformin: framed again?

BMJ (Clinical research ed.) 20091223

Metformin as an addition to conventional chemotherapy in breast cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20091210

Triple verses glimepiride plus metformin therapy on cardiovascular risk biomarkers and diabetic cardiomyopathy in insulin resistance type 2 diabetes mellitus rats.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20091208

Sulphonylureas and cancer: a case-control study.

Acta diabetologica 20091201

Impact of acute kidney injury on metformin-associated lactic acidosis.

International urology and nephrology 20091201

Long-standing hidradenitis suppurativa treated effectively with metformin.

Clinical and experimental dermatology 20091201

Changes in health state utilities with changes in body mass in the Diabetes Prevention Program.

Obesity (Silver Spring, Md.) 20091201

The backbone of oral glucose-lowering therapy: time for a paradigm shift?

Fundamental & clinical pharmacology 20091201

Recovery of acanthosis nigricans under prolonged metformin treatment in an adolescent with normal weight.

Journal of endocrinological investigation 20091201

Acute metformin overdose: examining serum pH, lactate level, and metformin concentrations in survivors versus nonsurvivors: a systematic review of the literature.

Annals of emergency medicine 20091201

Activation of AMP-activated kinase as a strategy for managing autosomal dominant polycystic kidney disease.

Medical hypotheses 20091201

Androgen receptor antagonism and an insulin sensitizer block the advancement of vaginal opening by high-fat diet in mice.

Biology of reproduction 20091201

Drug sorption onto and release from soy protein fibers.

Journal of materials science. Materials in medicine 20091201

Synergistic effect of phytochemicals in combination with hypoglycemic drugs on glucose uptake in myotubes.

Phytomedicine : international journal of phytotherapy and phytopharmacology 20091201

Osteoblast differentiation is functionally associated with decreased AMP kinase activity.

Journal of cellular physiology 20091201

Comparison of metformin treatment and laparoscopic ovarian diathermy in patients with polycystic ovary syndrome.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20091201

The European Exenatide study of long-term exenatide vs. glimepiride for type 2 diabetes: rationale and patient characteristics.

Diabetes, obesity & metabolism 20091201

Effects of pioglitazone and rosiglitazone combined with metformin on body weight in people with diabetes.

Diabetes, obesity & metabolism 20091201

Spectrophotometric and HPLC determinations of anti-diabetic drugs, rosiglitazone maleate and metformin hydrochloride, in pure form and in pharmaceutical preparations.

European journal of medicinal chemistry 20091201

Glucose homeostasis is impaired by a paradoxical interaction between metformin and insulin in carnivorous rainbow trout.

American journal of physiology. Regulatory, integrative and comparative physiology 20091201

Management strategies for ovulation induction in women with polycystic ovary syndrome and known clomifene citrate resistance.

Current opinion in obstetrics & gynecology 20091201

Efficacy and safety of pioglitazone/metformin fixed-dose combination therapy compared with pioglitazone and metformin monotherapy in treating patients with T2DM.

Current medical research and opinion 20091201

Development of Gelucire 43/01 beads of metformin hydrochloride for floating delivery.

AAPS PharmSciTech 20091201

Changes in weight and metabolic parameters during treatment with antipsychotics and metformin: do the data inform as to potential guideline development? A systematic review of clinical studies.

International journal of clinical practice 20091201

Treatment of insulin resistance with metformin in naïve genotype 1 chronic hepatitis C patients receiving peginterferon alfa-2a plus ribavirin.

Hepatology (Baltimore, Md.) 20091201

Lipase maturation factor 1: its expression in Zucker diabetic rats, and effects of metformin and fenofibrate.

Diabetes & metabolism 20091201

LKB1 and mammalian target of rapamycin as predictive factors for the anticancer efficacy of metformin.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20091201

Comparison of simvastatin and metformin in treatment of polycystic ovary syndrome: prospective randomized trial.

The Journal of clinical endocrinology and metabolism 20091201

Metformin toxicity.

European journal of emergency medicine : official journal of the European Society for Emergency Medicine 20091201

Current understanding of the pharmacogenomics of metformin.

Clinical pharmacology and therapeutics 20091201

Can metformin or rosiglitazone reduce metabolic side effects associated with atypical antipsychotics?

Issues in mental health nursing 20091201

Effects of Escherichia coli lipopolysaccharide on the metformin pharmacokinetics in rats.

Xenobiotica; the fate of foreign compounds in biological systems 20091201

Metformin, hepatitis C, and insulin resistance: sufficient evidence?

Hepatology (Baltimore, Md.) 20091201

Drugs that suppress TSH or cause central hypothyroidism.

Best practice & research. Clinical endocrinology & metabolism 20091201

Dapagliflozin, an oral sodium glucose cotransporter type 2 inhibitor for the treatment of type 2 diabetes mellitus.

IDrugs : the investigational drugs journal 20091201

Pharmacokinetics and bioequivalence evaluation of gliclazide/metformin combination tablet and equivalent doses of gliclazide and metformin in healthy Korean subjects.

International journal of clinical pharmacology and therapeutics 20091201

Metformin increases plasma ghrelin in Type 2 diabetes.

British journal of clinical pharmacology 20091201

Long-term glycaemic effects of pioglitazone compared with placebo as add-on treatment to metformin or sulphonylurea monotherapy in PROactive (PROactive 18).

Diabetic medicine : a journal of the British Diabetic Association 20091201

Comparison of antihyperglycemic effects of creatine and metformin in type II diabetic patients.

Clinical and investigative medicine. Medecine clinique et experimentale 20091201

Mysterious metformin.

The oncologist 20091201

Effects of metformin on serum levels of sex hormone, leptin and insulin in ovariectomized Sprague-Dawley rats.

Die Pharmazie 20091201

Type 2 diabetes mellitus with pancreatic beta cell dysfunction in 3 horses confirmed with minimal model analysis.

Equine veterinary journal 20091201

Serum bicarbonate: can it be a marker of metformin induced acidosis in geriatrics?

Nepal Medical College journal : NMCJ 20091201

Metformin primarily decreases plasma glucose not by gluconeogenesis suppression but by activating glucose utilization in a non-obese type 2 diabetes Goto-Kakizaki rats.

European journal of pharmacology 20091125

If mammalian target of metformin indirectly is mammalian target of rapamycin, then the insulin-like growth factor-1 receptor axis will audit the efficacy of metformin in cancer clinical trials.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20091120

Adiponectin downregulates galectin-3 whose cellular form is elevated whereas its soluble form is reduced in type 2 diabetic monocytes.

FEBS letters 20091119

AMPK: Evidence for an energy-sensing cytokinetic tumor suppressor.

Cell cycle (Georgetown, Tex.) 20091115

Metformin use in renal dysfunction: is a serum creatinine threshold appropriate?

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20091115

10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.

Lancet (London, England) 20091114

Yin-Yang regulation of adiponectin signaling by APPL isoforms in muscle cells.

The Journal of biological chemistry 20091113

Continuation of metformin after introduction of insulin in type 2 diabetes.

BMJ (Clinical research ed.) 20091109

Relationship of plasma creatinine and lactic acid in type 2 diabetic patients without renal dysfunction.

Chinese medical journal 20091105

Effect of preconceptional metformin on abortion risk in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials.

Fertility and sterility 20091101

Metformin use and prostate cancer in Caucasian men: results from a population-based case-control study.

Cancer causes & control : CCC 20091101

Effects of 1-year treatment with metformin on metabolic and cardiovascular risk factors in non-diabetic upper-body obese subjects with mild glucose anomalies: a post-hoc analysis of the BIGPRO1 trial.

Diabetes & metabolism 20091101

Glucose, metformin, and AICAR regulate the expression of G protein-coupled receptor members in INS-1 beta cell.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20091101

Depression, depression treatment, and insulin sensitivity in adults at risk for type 2 diabetes.

Diabetes research and clinical practice 20091101

Interaction of beta-blockers with the renal uptake transporter OCT2.

Diabetes, obesity & metabolism 20091101

A comparison of uptake of metformin and phenformin mediated by hOCT1 in human hepatocytes.

Biopharmaceutics & drug disposition 20091101

Determination of metformin in human plasma using hydrophilic interaction liquid chromatography-tandem mass spectrometry.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20091101

Establishment and characterization of a novel method for evaluating gluconeogenesis using hepatic cell lines, H4IIE and HepG2.

Archives of biochemistry and biophysics 20091101

Protective role of the antidiabetic drug metformin against chronic experimental pulmonary hypertension.

British journal of pharmacology 20091101

[Female patient with type 2 diabetes in coma with metabolic acidosis].

Der Internist 20091101

Goals of treatment for type 2 diabetes: beta-cell preservation for glycemic control.

Diabetes care 20091101

Changing the treatment paradigm for type 2 diabetes.

Diabetes care 20091101

Beta-cell protection and therapy for latent autoimmune diabetes in adults.

Diabetes care 20091101

Is there evidence that oral hypoglycemic agents reduce cardiovascular morbidity or mortality? No.

Diabetes care 20091101

Is there evidence that oral hypoglycemic agents reduce cardiovascular morbidity/mortality? Yes.

Diabetes care 20091101

A summary of the ADVANCE Trial.

Diabetes care 20091101

Clinical practice in type 2 diabetes: After metformin and lifestyle, then what?

The Journal of family practice 20091101

Rationale, design, and baseline data of the insulin glargine (Lantus) versus insulin detemir (Levemir) Treat-To-Target (L2T3) study: A multinational, randomized noninferiority trial of basal insulin initiation in type 2 diabetes.

Diabetes technology & therapeutics 20091101

Comparative study of low-dose pioglitazone or metformin treatment in Japanese diabetic patients with metabolic syndrome.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20091101

[Liraglutide: a human GLP-1 analogue for the treatment of diabetes mellitus type 2].

Medizinische Monatsschrift fur Pharmazeuten 20091101

Treating type 2 diabetes. A specialist's approach.

Advance for nurse practitioners 20091101

Metformin--a convenient alternative to insulin for Indian women with diabetes in pregnancy.

Indian journal of medical sciences 20091101

Grapefruit juice improves glycemic control but exacerbates metformin-induced lactic acidosis in non-diabetic rats.

Methods and findings in experimental and clinical pharmacology 20091101

Metformin inhibits nuclear factor kappaB activation and decreases serum high-sensitivity C-reactive protein level in experimental atherogenesis of rabbits.

Heart and vessels 20091101

Pharmacokinetic comparison of a new glimepiride 1-mg + metformin 500-mg combination tablet formulation and a glimepiride 2-mg + metformin 500-mg combination tablet formulation: a single-dose, randomized, open-label, two-period, two-way crossover study in healthy, fasting Korean male volunteers.

Clinical therapeutics 20091101

Combined pioglitazone and metformin treatment maintains the beneficial effect of short-term insulin infusion in patients with type 2 diabetes: results from a pilot study.

Journal of diabetes science and technology 20091101

Effect of metformin on miscarriage in pregnant patients with polycystic ovary syndrome.

The West Indian medical journal 20091101

Metformin: fifty-two not out.

Journal of the Indian Medical Association 20091101

Three-year efficacy of complex insulin regimens in type 2 diabetes.

The New England journal of medicine 20091029

Saxagliptin.

Drugs 20091022

Metformin suppresses glucose-6-phosphatase expression by a complex I inhibition and AMPK activation-independent mechanism.

Biochemical and biophysical research communications 20091016

Determination of metformin and its prodrugs in human and rat blood by hydrophilic interaction liquid chromatography.

Journal of pharmaceutical and biomedical analysis 20091015

Development and validation of an analytical method for metformin hydrochloride and its related compound (1-cyanoguanidine) in tablet formulations by HPLC-UV.

Talanta 20091015

[Type 2 diabetes: interview with Prof. Stephan Matthaei. Reaching HbA1c target value while preventing hypoglycemia].

MMW Fortschritte der Medizin 20091015

[Combination antidiabetic therapy. Better control of blood glucose values].

MMW Fortschritte der Medizin 20091015

Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility.

The Cochrane database of systematic reviews 20091007

Metformin restores impaired HDL-mediated cholesterol efflux due to glycation.

Atherosclerosis 20091001

Vertebral fractures in males with type 2 diabetes treated with rosiglitazone.

Bone 20091001

Twice-daily and three-times-daily dosing of a repaglinide/metformin fixed-dose combination tablet provide similar glycaemic control.

Diabetes, obesity & metabolism 20091001

Short-term metformin treatment for clomiphene citrate-resistant women with polycystic ovary syndrome.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20091001

Effect of adjunct metformin treatment on levels of plasma lipids in patients with type 1 diabetes.

Diabetes, obesity & metabolism 20091001

Is it the time for metformin to take place in adjuvant treatment of Her-2 positive breast cancer? Teaching new tricks to old dogs.

Medical hypotheses 20091001

Metformin promotes induction of lipoprotein lipase in skeletal muscle through activation of adenosine monophosphate-activated protein kinase.

Metabolism: clinical and experimental 20091001

Metformin inhibits aromatase via an extracellular signal-regulated kinase-mediated pathway.

Endocrinology 20091001

Regulation of glucose-6-phosphatase gene expression by insulin and metformin.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20091001

Changes in insulin secretion and insulin sensitivity in relation to the glycemic outcomes in subjects with impaired glucose tolerance in the Indian Diabetes Prevention Programme-1 (IDPP-1).

Diabetes care 20091001

Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver.

Hepatology (Baltimore, Md.) 20091001

Insulin-based versus triple oral therapy for newly diagnosed type 2 diabetes: which is better?

Diabetes care 20091001

Comparison of vildagliptin and thiazolidinedione as add-on therapy in patients inadequately controlled with metformin: results of the GALIANT trial--a primary care, type 2 diabetes study.

Diabetes, obesity & metabolism 20091001

Effects of guggulsterone isolated from Commiphora mukul in high fat diet induced diabetic rats.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20091001

Effect of rosiglitazone, metformin and medical nutrition treatment on arterial stiffness, serum MMP-9 and MCP-1 levels in drug naive type 2 diabetic patients.

Diabetes research and clinical practice 20091001

Metformin: diamonds are forever.

Expert opinion on pharmacotherapy 20091001

Vildagliptin therapy and hypoglycaemia in Muslim type 2 diabetes patients during Ramadan.

International journal of clinical practice 20091001

Effects of bed-time insulin versus pioglitazone on abdominal fat accumulation, inflammation and gene expression in adipose tissue in patients with type 2 diabetes.

Diabetes research and clinical practice 20091001

Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): a randomised controlled trial.

Diabetologia 20091001

Baicalin reduces mitochondrial damage in streptozotocin-induced diabetic Wistar rats.

Diabetes/metabolism research and reviews 20091001

Metformin does not improve the reproductive or metabolic profile in women with polycystic ovary syndrome (PCOS).

Reproductive sciences (Thousand Oaks, Calif.) 20091001

The transmembrane transport of metformin by osteoblasts from rat mandible.

Archives of oral biology 20091001

Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission.

Cancer research 20091001

Zinc-activated C-peptide resistance to the type 2 diabetic erythrocyte is associated with hyperglycemia-induced phosphatidylserine externalization and reversed by metformin.

Molecular bioSystems 20091001

Metformin in the treatment of clomiphene citrate-resistant women with polycystic ovary syndrome undergoing in vitro fertilisation treatment: a randomised controlled trial.

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 20091001

Diabetic diarrhea.

Current gastroenterology reports 20091001

Oral glucose tolerance test (OGTT) in normal control and glucose induced hyperglycemic rats with Coccinia cordifolia l. and Catharanthus roseus L.

Pakistan journal of pharmaceutical sciences 20091001

Hepatic drug transporters, old and new: pharmacogenomics, drug response, and clinical relevance.

Hepatology (Baltimore, Md.) 20091001

Therapies for type 2 diabetes and coronary artery disease.

The New England journal of medicine 20091001

Hyperinsulinemia and risk for hepatocellular carcinoma in patients with chronic liver diseases and Type 2 diabetes mellitus.

Expert review of gastroenterology & hepatology 20091001

[Oral hypoglycaemic agents in 2009].

Therapeutische Umschau. Revue therapeutique 20091001

[Insulin and type 2 diabetes mellitus].

Therapeutische Umschau. Revue therapeutique 20091001

Gastroretentive drug delivery of metformin hydrochloride: formulation and in vitro evaluation using 3(2) full factorial design.

Current drug delivery 20091001

Long-term glycaemic control with metformin-sulphonylurea-pioglitazone triple therapy in PROactive (PROactive 17).

Diabetic medicine : a journal of the British Diabetic Association 20091001

Adipose tissue, metabolic syndrome and polycystic ovary syndrome: from pathophysiology to treatment.

Reproductive biomedicine online 20091001

Insulin sensitizers in nonalcoholic fatty liver disease and steatohepatitis: Current status.

Advances in therapy 20091001

[Glargine insulin and cancer risk].

Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion 20091001

Polycystic ovary syndrome and metabolic comorbidities: therapeutic options.

Drugs of today (Barcelona, Spain : 1998) 20091001

[Photosensitivity induced by metformin: a report of 3 cases].

La Tunisie medicale 20091001

Antidiabetic effects of Artemisia sphaerocephala Krasch. gum, a novel food additive in China, on streptozotocin-induced type 2 diabetic rats.

Journal of ethnopharmacology 20090925

Effects of initiating insulin and metformin on glycemic control and inflammatory biomarkers among patients with type 2 diabetes: the LANCET randomized trial.

JAMA 20090916

Metformin associated lactic acidosis.

BMJ (Clinical research ed.) 20090916

Attenuation of hepatic expression and secretion of selenoprotein P by metformin.

Biochemical and biophysical research communications 20090911

[Polycystic ovary syndrome. Diet helps control hormone chaos].

MMW Fortschritte der Medizin 20090910

Investigating infertility.

BMJ (Clinical research ed.) 20090909

Low-dose pioglitazone and low-dose flutamide added to metformin and oestro-progestagens for hyperinsulinaemic women with androgen excess: add-on benefits disclosed by a randomized double-placebo study over 24 months.

Clinical endocrinology 20090901

Supplementation with cholecalciferol does not improve glycaemic control in diabetic subjects with normal serum 25-hydroxyvitamin D levels.

European journal of nutrition 20090901

Twice-daily dosing of a repaglinide/metformin fixed-dose combination tablet provides glycaemic control comparable to rosiglitazone/metformin tablet.

Diabetes, obesity & metabolism 20090901

The efficacy and safety of saxagliptin when added to metformin therapy in patients with inadequately controlled type 2 diabetes with metformin alone.

Diabetes care 20090901

The effect of metformin in overweight patients with type 1 diabetes and poor metabolic control.

Basic & clinical pharmacology & toxicology 20090901

Insulin and metformin regulate circulating and adipose tissue chemerin.

Diabetes 20090901

Effect of DHEA and metformin on corpus luteum in mice.

Reproduction (Cambridge, England) 20090901

TSH-lowering effect of metformin in type 2 diabetic patients: differences between euthyroid, untreated hypothyroid, and euthyroid on L-T4 therapy patients.

Diabetes care 20090901

Metformin for obesity in children and adolescents: a systematic review.

Diabetes care 20090901

Effects of rosiglitazone on fasting plasma fibroblast growth factor-21 levels in patients with type 2 diabetes mellitus.

European journal of endocrinology 20090901

The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin.

Clinical pharmacology and therapeutics 20090901

Diabetes medications and body weight.

Expert opinion on drug safety 20090901

Metformin improves postprandial glucose homeostasis in rainbow trout fed dietary carbohydrates: a link with the induction of hepatic lipogenic capacities?

American journal of physiology. Regulatory, integrative and comparative physiology 20090901

New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes.

Diabetes care 20090901

The influence of glucose-lowering therapies on cancer risk in type 2 diabetes.

Diabetologia 20090901

Regression from pre-diabetes to normal glucose regulation in the diabetes prevention program.

Diabetes care 20090901

Telmisartan inhibits cytokine-induced nuclear factor-kappaB activation independently of the peroxisome proliferator-activated receptor-gamma.

Hypertension research : official journal of the Japanese Society of Hypertension 20090901

Earlier triple therapy with pioglitazone in patients with type 2 diabetes.

Diabetes, obesity & metabolism 20090901

Rationale and design of a clinical trial to evaluate metformin and colesevelam HCl as first-line therapy in type 2 diabetes and colesevelam HCl in prediabetes.

Current medical research and opinion 20090901

Selective regulation of cellular and secreted multimeric adiponectin by antidiabetic therapies in humans.

American journal of physiology. Endocrinology and metabolism 20090901

Total and acylated ghrelin levels in type 2 diabetic patients: similar levels observed after treatment with metformin, pioglitazone or diet therapy.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20090901

Antidiabetic agents and cardiovascular risk in type 2 diabetes.

Nature reviews. Endocrinology 20090901

In situ forming formulation: development, evaluation, and optimization using 3(3) factorial design.

AAPS PharmSciTech 20090901

Rosiglitazone maleate + metformin hydrochloride extend: review of an emerging compound.

Expert opinion on investigational drugs 20090901

Association of scavenger receptors in adipose tissue with insulin resistance in nondiabetic humans.

Arteriosclerosis, thrombosis, and vascular biology 20090901

Pharmacotherapy in pediatric obesity: current agents and future directions.

Reviews in endocrine & metabolic disorders 20090901

Diabetes: HOME reveals new data on a cornerstone of treatment.

Nature reviews. Endocrinology 20090901

Metformin, cancer, alphabet soup, and the role of epidemiology in etiologic research.

Diabetes care 20090901

Expanding the arsenal: metformin for the treatment of triple-negative breast cancer?

Cell cycle (Georgetown, Tex.) 20090901

[Usefulness of metformin in diabetes-related bone disease].

Clinical calcium 20090901

Occurrence of the antidiabetic drug metformin in sewage and surface waters in Germany.

Journal of environmental monitoring : JEM 20090901

Selecting among ADA/EASD tier 1 and tier 2 treatment options.

The Journal of family practice 20090901

Practical applications of therapy with a glucagon-like peptide-1 receptor agonist.

The Journal of family practice 20090901

Patient education and monitoring recommendations for the use of glucagon-like peptide-1 receptor agonists.

The Journal of family practice 20090901

Is it time to test metformin in breast cancer prevention trials? A reply to the authors.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20090901

Initiation of prandial insulin therapy with AIR inhaled insulin or insulin lispro in patients with type 2 diabetes: A randomized noninferiority trial.

Diabetes technology & therapeutics 20090901

A comparison between simplified and intensive dose-titration algorithms using AIR inhaled insulin for insulin-naive patients with type 2 diabetes in a randomized noninferiority trial.

Diabetes technology & therapeutics 20090901

Treating patients with type 2 diabetes: what is after lifestyle management and metformin? A focus on the glucagon-like peptide-1 receptor agonists.

The Journal of family practice 20090901

Continuous venovenous haemodiafiltration for metformin-induced lactic acidosis.

Anaesthesia and intensive care 20090901

In vivo metabolic phenotyping of myocardial substrate metabolism in rodents: differential efficacy of metformin and rosiglitazone monotherapy.

Circulation. Cardiovascular imaging 20090901

Metformin-diet ameliorates coronary heart disease risk factors and facilitates resumption of regular menses in adolescents with polycystic ovary syndrome.

Journal of pediatric endocrinology & metabolism : JPEM 20090901

Ultra-performance hydrophilic interaction LC-MS/MS for the determination of metformin in mouse plasma.

Bioanalysis 20090901

[Use of metformin in polycystic ovary syndrome].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20090827

Metformin, diet and breast cancer: an avenue for chemoprevention.

Cell cycle (Georgetown, Tex.) 20090815

Metformin disrupts crosstalk between G protein-coupled receptor and insulin receptor signaling systems and inhibits pancreatic cancer growth.

Cancer research 20090815

[Primary preventive effect of metformin upon atherosclerosis in patients with type 2 diabetes mellitus].

Zhonghua yi xue za zhi 20090811

The effect of metformin treatment on ovarian stromal blood flow in women with polycystic ovary syndrome.

Archives of gynecology and obstetrics 20090801

Amelioration of metformin-induced hypothyroidism by Withania somnifera and Bauhinia purpurea extracts in Type 2 diabetic mice.

Phytotherapy research : PTR 20090801

The effects of brain-derived neurotrophic factor and metformin on in vitro developmental competence of bovine oocytes.

Zygote (Cambridge, England) 20090801

Antidiabetic therapies affect risk of pancreatic cancer.

Gastroenterology 20090801

Genetic variation in the organic cation transporter 1 is associated with metformin response in patients with diabetes mellitus.

The pharmacogenomics journal 20090801

Metformin in combination with structured lifestyle intervention improved body mass index in obese adolescents, but did not improve insulin resistance.

Endocrine 20090801

Direct comparison among oral hypoglycemic agents and their association with insulin resistance evaluated by euglycemic hyperinsulinemic clamp: the 60's study.

Metabolism: clinical and experimental 20090801

Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic beta-cell at submaximal glucose concentrations.

Endocrinology 20090801

Metformin decreases angiogenesis via NF-kappaB and Erk1/2/Erk5 pathways by increasing the antiangiogenic thrombospondin-1.

Cardiovascular research 20090801

Pleiotropic action of short-term metformin and fenofibrate treatment, combined with lifestyle intervention, in type 2 diabetic patients with mixed dyslipidemia.

Diabetes care 20090801

Prescribing metformin in type 2 diabetes with a contraindication: prevalence and outcome.

Pharmacy world & science : PWS 20090801

A cohort study of thiazolidinediones and fractures in older adults with diabetes.

The Journal of clinical endocrinology and metabolism 20090801

Comparison of vildagliptin and metformin monotherapy in elderly patients with type 2 diabetes: a 24-week, double-blind, randomized trial.

Diabetes, obesity & metabolism 20090801

Antihyperglycaemic medication modifies factors of postprandial satiety in type 2 diabetes.

Diabetes, obesity & metabolism 20090801

Adiponectin downregulates CD163 whose cellular and soluble forms are elevated in obesity.

European journal of clinical investigation 20090801

Effects of metformin on mammalian target of rapamycin in a mouse model of endometrial hyperplasia.

European journal of obstetrics, gynecology, and reproductive biology 20090801

Extended release metformin for metabolic control assistance during prolonged clozapine administration: a 14 week, double-blind, parallel group, placebo-controlled study.

Schizophrenia research 20090801

Evaluation of the potential for steady-state pharmacokinetic and pharmacodynamic interactions between the DPP-4 inhibitor linagliptin and metformin in healthy subjects.

Current medical research and opinion 20090801

Effect of metformin on weight gain during antihypertensive treatment with a beta-blocker in Chinese patients.

American journal of hypertension 20090801

Sustained hyperglycemia among patients with diabetes: what matters when action is needed?

Diabetes care 20090801

The use of oral antidiabetic medications in gestational diabetes mellitus.

Current diabetes reports 20090801

The use of metformin in the management of polycystic ovary syndrome and associated anovulatory infertility: the current evidence.

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 20090801

Pregnancy outcomes in women with gestational diabetes treated with metformin or insulin: a case-control study.

Diabetic medicine : a journal of the British Diabetic Association 20090801

Type 2 diabetes: target HbA1c of about 7%.

Prescrire international 20090801

Clinical results of treating type 2 diabetic patients with sitagliptin, vildagliptin or saxagliptin--diabetes control and potential adverse events.

Best practice & research. Clinical endocrinology & metabolism 20090801

[Glycemic control in type 2 diabetic patients in public and private healthcare service].

Arquivos brasileiros de endocrinologia e metabologia 20090801

The role of insulin-sensitizing agents in the treatment of polycystic ovary syndrome.

Drugs 20090730

The first bioreversible prodrug of metformin with improved lipophilicity and enhanced intestinal absorption.

Journal of medicinal chemistry 20090723

Regulation of visceral adipose tissue-derived serine protease inhibitor by nutritional status, metformin, gender and pituitary factors in rat white adipose tissue.

The Journal of physiology 20090715

Assessment of genomic instability in normal and diabetic rats treated with metformin.

Chemico-biological interactions 20090715

Metformin in breast cancer: time for action.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090710

Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090710

WITHDRAWN: Insulin-sensitising drugs for polycystic ovary syndrome.

The Cochrane database of systematic reviews 20090708

Enhancing CD8 T-cell memory by modulating fatty acid metabolism.

Nature 20090702

Immunology: A metabolic switch to memory.

Nature 20090702

Pioglitazone vs glimepiride: Differential effects on vascular endothelial function in patients with type 2 diabetes.

Atherosclerosis 20090701

Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD).

Diabetes care 20090701

Metformin usages in women with heart failure.

American journal of obstetrics and gynecology 20090701

Lysophosphatidylcholine--biomarker of Metformin action: studied using UPLC/MS/MS.

Biomedical chromatography : BMC 20090701

Anti-Müllerian hormone concentrations in androgen-suppressed women with polycystic ovary syndrome.

Human reproduction (Oxford, England) 20090701

Treatment with the human once-weekly glucagon-like peptide-1 analog taspoglutide in combination with metformin improves glycemic control and lowers body weight in patients with type 2 diabetes inadequately controlled with metformin alone: a double-blind placebo-controlled study.

Diabetes care 20090701

Metformin in renal failure--weigh the evidence.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20090701

Beneficial endocrine but adverse exocrine effects of sitagliptin in the human islet amyloid polypeptide transgenic rat model of type 2 diabetes: interactions with metformin.

Diabetes 20090701

Independent anti-inflammatory effect of insulin in newly diagnosed type 2 diabetes.

Diabetes/metabolism research and reviews 20090701

Adjuncts for ovarian stimulation: when do we adopt 'orphan indications' for approved drugs?

Fertility and sterility 20090701

Does glucose infusion exacerbate metformin-associated lactate acidosis? A case report.

Diabetes research and clinical practice 20090701

Metformin induces unique biological and molecular responses in triple negative breast cancer cells.

Cell cycle (Georgetown, Tex.) 20090701

Three different premixed combinations of biphasic insulin aspart - comparison of the efficacy and safety in a randomized controlled clinical trial in subjects with type 2 diabetes.

Diabetes, obesity & metabolism 20090701

The effects of metformin on uterine tissue of hyperandrogenized BALB/c mice.

Molecular human reproduction 20090701

Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin.

Pharmacogenetics and genomics 20090701

Metformin-associated lactic acidosis: a prognostic and therapeutic study.

Critical care medicine 20090701

Metformin administration was associated with a modification of LH, prolactin and insulin secretion dynamics in women with polycystic ovarian syndrome.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20090701

Why check metformin levels?

Critical care medicine 20090701

Nonalcoholic hepatic steatosis in Zucker diabetic rats: spontaneous evolution and effects of metformin and fenofibrate.

Obesity (Silver Spring, Md.) 20090701

Bone disease, gestational diabetes mellitus, and health care.

Diabetes care 20090701

Regulation of glyceraldehyde 3-phosphate dehydrogenase expression by metformin in HepG2 cells.

Biological & pharmaceutical bulletin 20090701

mTOR inhibitors and the anti-diabetic biguanide metformin: new insights into the molecular management of breast cancer resistance to the HER2 tyrosine kinase inhibitor lapatinib (Tykerb).

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20090701

Change in glucometer settings as a cause of sudden deterioration of glycemic control in type 2 diabetes.

Diabetes technology & therapeutics 20090701

Addressing metformin.

Canadian family physician Medecin de famille canadien 20090701

[Advantages of Chinese medicine for treatment of blood sugar and lipid metabolic disorders in patients with polycystic ovarian syndrome].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20090701

Simultaneous determination of metformin hydrochloride and pioglitazone hydrochloride in binary mixture and in their ternary mixture with pioglitazone acid degradate using spectrophotometric and chemometric methods.

Drug testing and analysis 20090701

[HbA1c 8.5% in elderly people with diabetes: is it good enough?].

MMW Fortschritte der Medizin 20090625

Thiazolidinediones and clinical outcomes in type 2 diabetes.

Lancet (London, England) 20090620

Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial.

Lancet (London, England) 20090620

Metformin attenuated the autoimmune disease of the central nervous system in animal models of multiple sclerosis.

Journal of immunology (Baltimore, Md. : 1950) 20090615

A randomized trial of therapies for type 2 diabetes and coronary artery disease.

The New England journal of medicine 20090611

Efficacy predictors for metformin and clomiphene citrate treatment in anovulatory infertile patients with polycystic ovary syndrome.

Fertility and sterility 20090601

Effects of metformin versus ethinyl-estradiol plus cyproterone acetate on ambulatory blood pressure monitoring and carotid intima media thickness in women with the polycystic ovary syndrome.

Fertility and sterility 20090601

The effect of metformin on leptin in obese patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease.

Acta diabetologica 20090601

Colesevelam HCl effects on atherogenic lipoprotein subclasses in subjects with type 2 diabetes.

Atherosclerosis 20090601

Disturbed stress responses in women with polycystic ovary syndrome.

Psychoneuroendocrinology 20090601

The risk of developing coronary artery disease or congestive heart failure, and overall mortality, in type 2 diabetic patients receiving rosiglitazone, pioglitazone, metformin, or sulfonylureas: a retrospective analysis.

Acta diabetologica 20090601

Glycemic variability correlates strongly with postprandial beta-cell dysfunction in a segment of type 2 diabetic patients using oral hypoglycemic agents.

Diabetes care 20090601

Functional characterization of the human organic cation transporter 2 variant p.270Ala>Ser.

Drug metabolism and disposition: the biological fate of chemicals 20090601

Exogenous glucose-dependent insulinotropic polypeptide worsens post prandial hyperglycemia in type 2 diabetes.

Diabetes 20090601

Glucagon-like peptide-1 receptor agonists in type 2 diabetes: a meta-analysis of randomized clinical trials.

European journal of endocrinology 20090601

Targeted disruption of the multidrug and toxin extrusion 1 (mate1) gene in mice reduces renal secretion of metformin.

Molecular pharmacology 20090601

Reduced-function SLC22A1 polymorphisms encoding organic cation transporter 1 and glycemic response to metformin: a GoDARTS study.

Diabetes 20090601

Concomitant reduction in low-density lipoprotein cholesterol and glycated hemoglobin with colesevelam hydrochloride in patients with type 2 diabetes: a pooled analysis.

Metabolic syndrome and related disorders 20090601

Autophagy in human type 2 diabetes pancreatic beta cells.

Diabetologia 20090601

A cost-effectiveness analysis of pioglitazone plus metformin compared with rosiglitazone plus metformin from a third-party payer perspective in the US.

Current medical research and opinion 20090601

Balancing risk and benefit with oral hypoglycemic drugs.

The Mount Sinai journal of medicine, New York 20090601

AMP-activated protein kinase-dependent and -independent mechanisms underlying in vitro antiglioma action of compound C.

Biochemical pharmacology 20090601

Current therapeutic drugs for type 2 diabetes, still useful after 50 years?

Anesthesia and analgesia 20090601

Reduced daily risk of glycemic variability: comparison of exenatide with insulin glargine.

Diabetes technology & therapeutics 20090601

Competact, a fixed combination of pioglitazone and metformin, improves metabolic markers in type 2 diabetes patients with insufficient glycemic control by metformin alone--results from a post-marketing surveillance trial under daily routine conditions.

Diabetes technology & therapeutics 20090601

[Metformin also as first choice in patients with normal weight. Has its use increased?].

Atencion primaria 20090601

Management of atypical antipsychotic drug-induced weight gain: focus on metformin.

Pharmacotherapy 20090601

Metformin/Repaglinide (PrandiMet) for type 2 diabetes.

The Medical letter on drugs and therapeutics 20090601

Metformin and insulin meet in a most atypical way.

Cell metabolism 20090601

Ethnic origin is unrelated to autoimmunity and residual pancreatic function in 471 youth with clinically diagnosed type 2 diabetes.

Pediatric diabetes 20090601

Metformin is a unique drug.

Canadian family physician Medecin de famille canadien 20090601

Taking the stress out of insulin initiation in type 2 diabetes mellitus.

Canadian family physician Medecin de famille canadien 20090601

Comparison of vildagliptin and pioglitazone in patients with type 2 diabetes inadequately controlled with metformin.

Diabetes, obesity & metabolism 20090601

Saxagliptin given in combination with metformin as initial therapy improves glycaemic control in patients with type 2 diabetes compared with either monotherapy: a randomized controlled trial.

Diabetes, obesity & metabolism 20090601

Metformin for weight control in pediatric patients on atypical antipsychotic medication.

Journal of child and adolescent psychopharmacology 20090601

Investigation of the effect of oral metformin on dipeptidylpeptidase-4 (DPP-4) activity in Type 2 diabetes.

Diabetic medicine : a journal of the British Diabetic Association 20090601

The effects of calcium-vitamin D and metformin on polycystic ovary syndrome: a pilot study.

Taiwanese journal of obstetrics & gynecology 20090601

Sitagliptin + metformin: new combination. Do not use this combination. Sitagliptin provides a slight increase of glucose-lowering effects, but there is a disturbing potential for long-term adverse effects: infections, depression, and cancer.

Prescrire international 20090601

Non-functional parathyroid carcinoma: a review of the literature and report of a case requiring extensive surgery.

Head and neck pathology 20090601

[Metformin effects upon blood pressure and glucose metabolism of monossodium glutamate induced-obese spontaneously hypertensive rats].

Arquivos brasileiros de endocrinologia e metabologia 20090601

Initial therapy for type 2 diabetes. Examination of a combination approach.

Advance for nurse practitioners 20090601

Baicalin improves antioxidant status of streptozotocin-induced diabetic Wistar rats.

Journal of agricultural and food chemistry 20090527

Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase.

Circulation 20090519

Metformin inhibits TNF-alpha-induced IkappaB kinase phosphorylation, IkappaB-alpha degradation and IL-6 production in endothelial cells through PI3K-dependent AMPK phosphorylation.

International journal of cardiology 20090515

Genome-wide inhibitory impact of the AMPK activator metformin on [kinesins, tubulins, histones, auroras and polo-like kinases] M-phase cell cycle genes in human breast cancer cells.

Cell cycle (Georgetown, Tex.) 20090515

Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein.

Cell 20090515

[Insulin secretion is increased depending on glucose.. Metabolism regulation in type 2 diabetes mellitus over five paths].

MMW Fortschritte der Medizin 20090507

[Anti-diabetic treatment, insulin resistance and cardiovascular disease in patients with type 2 diabetes].

Ugeskrift for laeger 20090504

Insulin resistance directly contributes to androgenic potential within ovarian theca cells.

Fertility and sterility 20090501

The effects of metformin on endogenous androgens and SHBG in women: a systematic review and meta-analysis.

Clinical endocrinology 20090501

One-year treatment with exenatide improves beta-cell function, compared with insulin glargine, in metformin-treated type 2 diabetic patients: a randomized, controlled trial.

Diabetes care 20090501

Efficacy and tolerability of vildagliptin in patients with type 2 diabetes inadequately controlled with metformin monotherapy.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20090501

Treatment choice and effectiveness of adding sulphonylurea or glitazones to metformin for the treatment of type 2 diabetes mellitus.

Diabetes, obesity & metabolism 20090501

Metabonomic study of biochemical changes in the serum of type 2 diabetes mellitus patients after the treatment of metformin hydrochloride.

Journal of pharmaceutical and biomedical analysis 20090501

Metformin prevents myocardial reperfusion injury by activating the adenosine receptor.

Journal of cardiovascular pharmacology 20090501

Continuous subcutaneous insulin infusion versus multiple daily insulin injections in type 2 diabetes: a meta-analysis.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20090501

Effect of two starting insulin regimens in patients with type II diabetes not controlled on a combination of oral antihyperglycemic medications.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20090501

Efficacy and safety of therapy with metformin plus pioglitazone in the treatment of patients with type 2 diabetes: a double-blind, placebo-controlled, clinical trial.

Current medical research and opinion 20090501

Vildagliptin plus metformin combination therapy provides superior glycaemic control to individual monotherapy in treatment-naive patients with type 2 diabetes mellitus.

Diabetes, obesity & metabolism 20090501

Study of the pharmacokinetic interaction of vildagliptin and metformin in patients with type 2 diabetes.

Current medical research and opinion 20090501

Incretin hormone secretion in women with polycystic ovary syndrome: roles of obesity, insulin sensitivity, and treatment with metformin.

Metabolism: clinical and experimental 20090501

Islet enhancer vildagliptin: a powerful partner with metformin for the treatment of patients with type 2 diabetes.

Diabetes, obesity & metabolism 20090501

Metformin--the gold standard in type 2 diabetes: what does the evidence tell us?

Diabetes, obesity & metabolism 20090501

The scientific evidence: vildagliptin and the benefits of islet enhancement.

Diabetes, obesity & metabolism 20090501

Translating science into clinical practice: focus on vildagliptin in combination with metformin.

Diabetes, obesity & metabolism 20090501

Gestational diabetes mellitus: developments in diagnosis and treatment.

Women's health (London, England) 20090501

Role of metformin in the treatment of gestational diabetes.

The Annals of pharmacotherapy 20090501

Pharmacokinetics and bioavailability of metformin in horses.

American journal of veterinary research 20090501

Pharmacological interventions for nonalcoholic fatty liver disease in adults and in children: a systematic review.

Journal of pediatric gastroenterology and nutrition 20090501

[Protective effects of metformin on low-density lipoprotein-induced endothelial dysfunction in rats].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20090501

Short-term treatment with metformin improves the cardiovascular risk profile in first-degree relatives of subjects with type 2 diabetes mellitus who have a metabolic syndrome and normal glucose tolerance without changes in C-reactive protein or fibrinogen.

Clinics (Sao Paulo, Brazil) 20090501

By the way, doctor. I've had type 2 diabetes for 12 years; I'm now 81. I take metformin plus Januvia. My doctor has never suggested that I monitor myself on a daily basis with a meter. My hemoglobin A1c has been creeping up and is now at 7. Should I be getting more aggressive in my treatment?

Harvard health letter 20090501

In vive effects of gliclazide and metformin on the plasma concentration of caffeine in healthy rats.

Pakistan journal of biological sciences : PJBS 20090501

The renaissance of metformin in endocrine clinical practice.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20090501

Can technology improve adherence to long-term therapies?

Journal of diabetes science and technology 20090501

Pioglitazone improves cardiac function and alters myocardial substrate metabolism without affecting cardiac triglyceride accumulation and high-energy phosphate metabolism in patients with well-controlled type 2 diabetes mellitus.

Circulation 20090421

Lost in translation: modulation of the metabolic-functional relation in the diabetic human heart.

Circulation 20090421

Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome.

The Cochrane database of systematic reviews 20090415

[Progress in therapy for diabetes mellitus--insulin-resistance ameliorating agents].

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20090410

Structural determinants of inhibitor interaction with the human organic cation transporter OCT2 (SLC22A2).

Naunyn-Schmiedeberg's archives of pharmacology 20090401

[Metformine induces false-positive (18)F-FDG PET/CT uptake].

Presse medicale (Paris, France : 1983) 20090401

The effect of metformin on the incidence of type 2 diabetes mellitus and cardiovascular disease risk factors in overweight and obese subjects--the Carmos study.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20090401

An RCT of metformin versus orlistat for the management of obese anovulatory women.

Human reproduction (Oxford, England) 20090401

Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes.

Diabetes care 20090401

Changes in albumin excretion in the diabetes prevention program.

Diabetes care 20090401

Metabolic and endocrine effects of metformin and metformin plus cyclic medroxyprogesterone acetate in women with polycystic ovary syndrome.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20090401

Involvement of human multidrug and toxin extrusion 1 in the drug interaction between cimetidine and metformin in renal epithelial cells.

The Journal of pharmacology and experimental therapeutics 20090401

Effect of progression from impaired glucose tolerance to diabetes on cardiovascular risk factors and its amelioration by lifestyle and metformin intervention: the Diabetes Prevention Program randomized trial by the Diabetes Prevention Program Research Group.

Diabetes care 20090401

Simulated physician learning intervention to improve safety and quality of diabetes care: a randomized trial.

Diabetes care 20090401

Genetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function.

The pharmacogenomics journal 20090401

Glycemic control prevents microvascular remodeling and increased tone in type 2 diabetes: link to endothelin-1.

American journal of physiology. Regulatory, integrative and comparative physiology 20090401

Long-term improvement of metabolic control with pioglitazone in a woman with diabetes mellitus related to Dunnigan syndrome: a case report.

Diabetes & metabolism 20090401

Study rationale and design of the CIMT trial: the Copenhagen Insulin and Metformin Therapy trial.

Diabetes, obesity & metabolism 20090401

Pioglitazone treatment in type 2 diabetes mellitus when combined with portion control diet modifies the metabolic syndrome.

Diabetes, obesity & metabolism 20090401

Adherence in patients transferred from immediate release metformin to a sustained release formulation: a population-based study.

Diabetes, obesity & metabolism 20090401

AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease.

Clinical science (London, England : 1979) 20090401

Use of a claims-based active drug safety surveillance system to assess the risk of acute pancreatitis with exenatide or sitagliptin compared to metformin or glyburide.

Current medical research and opinion 20090401

The case. A suicidal woman with delayed high anion gap metabolic acidosis.

Kidney international 20090401

Free fatty acid kinetics during long-term treatment with pioglitazone added to sulfonylurea or metformin in Type 2 diabetes.

Journal of internal medicine 20090401

Metformin suppresses high glucose-induced poly(adenosine diphosphate-ribose) polymerase overactivation in aortic endothelial cells.

Metabolism: clinical and experimental 20090401

Hyperinsulinaemia and iron perturbation in patients with type 2 diabetes.

International journal of clinical practice 20090401

Effect of eslicarbazepine acetate on the pharmacokinetics of metformin in healthy subjects.

International journal of clinical pharmacology and therapeutics 20090401

Treating prediabetes with metformin: systematic review and meta-analysis.

Canadian family physician Medecin de famille canadien 20090401

Nateglinide combination therapy with basal insulin and metformin in patients with Type 2 diabetes.

Diabetic medicine : a journal of the British Diabetic Association 20090401

Evaluating the equivalence of clomiphene citrate with and without metformin in ovulation induction in PCOS patients.

Journal of assisted reproduction and genetics 20090401

Customised birthweight centiles are useful for identifying small-for-gestational-age babies in women with type 2 diabetes.

The Australian & New Zealand journal of obstetrics & gynaecology 20090401

Metformin-induced encephalopathy without lactic acidosis in a patient with contraindication for metformin.

Hemodialysis international. International Symposium on Home Hemodialysis 20090401

Is metformin beneficial for the treatment of infertility in women with PCOS?

JAAPA : official journal of the American Academy of Physician Assistants 20090401

[Alarming increase of the number of metformin intoxications. Ten times doubled number of inquiries to the Swedish Poison Information Center since 2000].

Lakartidningen 20090401

Insulin sensitizing actions of fenugreek seed polyphenols, quercetin & metformin in a rat model.

The Indian journal of medical research 20090401

Prevention of gestational diabetes mellitus by continuing metformin therapy throughout pregnancy in women with polycystic ovary syndrome.

The journal of obstetrics and gynaecology research 20090401

Metabonomic variations in the drug-treated type 2 diabetes mellitus patients and healthy volunteers.

Journal of proteome research 20090401

Long-term effect of metformin on metabolic parameters in the polycystic ovary syndrome.

Diabetes & vascular disease research 20090401

Long-term effects of metformin on metabolism and microvascular and macrovascular disease in patients with type 2 diabetes mellitus.

Archives of internal medicine 20090323

Antioxidant activity of chito-oligosaccharides on pancreatic islet cells in streptozotocin-induced diabetes in rats.

World journal of gastroenterology 20090321

[Certain beginning of insulin therapy: yes, we can, but...].

Praxis 20090318

Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro.

Cell cycle (Georgetown, Tex.) 20090315

Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERalpha negative MDA-MB-435 breast cancer model.

Breast cancer research and treatment 20090301

Utility of metformin in breast cancer treatment, is neoangiogenesis a risk factor?

Breast cancer research and treatment 20090301

Pioglitazone reduces monocyte activation in type 2 diabetes.

Acta diabetologica 20090301

Management and 1 year outcome for UK children with type 2 diabetes.

Archives of disease in childhood 20090301

Reduced antidiabetic effect of metformin and down-regulation of hepatic Oct1 in rats with ethynylestradiol-induced cholestasis.

Pharmaceutical research 20090301

Comparison of glycaemic control in patients with Type 2 diabetes on basal insulin and fixed combination oral antidiabetic treatment: results of a pilot study.

Acta diabetologica 20090301

Effects of an antiandrogenic oral contraceptive pill compared with metformin on blood coagulation tests and endothelial function in women with the polycystic ovary syndrome: influence of obesity and smoking.

European journal of endocrinology 20090301

The antidiabetic drug metformin: a pharmaceutical AMPK activator to overcome breast cancer resistance to HER2 inhibitors while decreasing risk of cardiomyopathy.

Annals of oncology : official journal of the European Society for Medical Oncology 20090301

Relationship between HbA1c and hypoglycaemia in patients with type 2 diabetes treated with different insulin regimens in combination with metformin.

Diabetes/metabolism research and reviews 20090301

Mechanism of action of metformin in nonalcoholic steatohepatitis.

Alimentary pharmacology & therapeutics 20090301

Self blood glucose monitoring in type 2 diabetes. A financial impact analysis based on UK primary care.

International journal of clinical practice 20090301

Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: a preliminary study.

Diabetes 20090301

Efficacy and safety of initial combination therapy with sitagliptin and metformin in patients with type 2 diabetes: a 54-week study.

Current medical research and opinion 20090301

Metabolic effect of repaglinide or acarbose when added to a double oral antidiabetic treatment with sulphonylureas and metformin: a double-blind, cross-over, clinical trial.

Current medical research and opinion 20090301

Is it time to test metformin in breast cancer clinical trials?

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20090301

Diabetes treatment.

Diabetes care 20090301

Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes: response to Nathan et al.

Diabetes care 20090301

Erlotinib-induced hepatitis complicated by fatal lactic acidosis in an elderly man with lung cancer.

The Annals of pharmacotherapy 20090301

Treatment with metformin is protective against limitations in instrumental activities of daily living in older subjects with type 2 diabetes mellitus.

Journal of the American Geriatrics Society 20090301

Metformin and atorvastatin reduce adhesion formation in a rat uterine horn model.

Reproductive biomedicine online 20090301

Prevalence of diabetic peripheral neuropathy and relation to glycemic control therapies at baseline in the BARI 2D cohort.

Journal of the peripheral nervous system : JPNS 20090301

Development of novel mucoadhesive pellets of metformin hydrochloride.

Archives of pharmacal research 20090301

[Effect of the Gly972Arg, SNP43 and Prol2Ala polymorphisms of the genes IRS1, CAPN10 and PPARG2 on secondary failure to sulphonylurea and metformin in patients with type 2 diabetes in Yucatán, México].

Investigacion clinica 20090301

[Vildagliptin (Galvus) and fixed combination vildagliptine-metformin (Eucreas) in the treatment of type 2 diabetes].

Revue medicale de Liege 20090301

Validation of anti-aging drugs by treating age-related diseases.

Aging 20090301

Comparative therapeutic effects of metformin and vitamin E in a model of non-alcoholic steatohepatitis in the young rat.

European journal of pharmacology 20090214

Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure.

Circulation research 20090213

Possible metformin effect on adrenal androgens during pretreatment and IVF cycle in women with polycystic ovary syndrome.

Fertility and sterility 20090201

Comparison of clomiphene citrate, metformin, or the combination of both for first-line ovulation induction, achievement of pregnancy, and live birth in Asian women with polycystic ovary syndrome: a randomized controlled trial.

Fertility and sterility 20090201

Continuation of metformin in the first trimester of women with polycystic ovarian syndrome is not associated with increased perinatal morbidity.

European journal of pediatrics 20090201

Effect of metformin, orlistat and pioglitazone treatment on mean insulin resistance and its biological variability in polycystic ovary syndrome.

Clinical endocrinology 20090201

Controlled release metformin hydrochloride microspheres of ethyl cellulose prepared by different methods and study on the polymer affected parameters.

Journal of microencapsulation 20090201

Clomiphene citrate, metformin or both as first-step approach in treating anovulatory infertility in patients with polycystic ovary syndrome (PCOS): a systematic review of head-to-head randomized controlled studies and meta-analysis.

Clinical endocrinology 20090201

Treatment of non-alcoholic fatty liver disease with metformin versus lifestyle intervention in insulin-resistant adolescents.

Pediatric diabetes 20090201

Severe metformin intoxication treated with prolonged haemodialyses and plasma exchange.

European journal of emergency medicine : official journal of the European Society for Emergency Medicine 20090201

Stimulation of lactate production in human granulosa cells by metformin and potential involvement of adenosine 5' monophosphate-activated protein kinase.

The Journal of clinical endocrinology and metabolism 20090201

The association of ENPP1 K121Q with diabetes incidence is abolished by lifestyle modification in the diabetes prevention program.

The Journal of clinical endocrinology and metabolism 20090201

The citrus fruit flavonoid naringenin suppresses hepatic glucose production from Fao hepatoma cells.

Molecular nutrition & food research 20090201

Metformin for the prevention of androgen deprivation induced metabolic syndrome, obesity and type 2 diabetes.

Medical hypotheses 20090201

O-glycoside biomarker of apolipoprotein C3: responsiveness to obesity, bariatric surgery, and therapy with metformin, to chronic or severe liver disease and to mortality in severe sepsis and graft vs host disease.

Journal of proteome research 20090201

Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review.

Endocrine reviews 20090201

Fifty-two-week efficacy and safety of vildagliptin vs. glimepiride in patients with type 2 diabetes mellitus inadequately controlled on metformin monotherapy.

Diabetes, obesity & metabolism 20090201

Nateglinide and glibenclamide metabolic effects in naïve type 2 diabetic patients treated with metformin.

Journal of clinical pharmacy and therapeutics 20090201

Adiponectin upregulates monocytic activin A but systemic levels are not altered in obesity or type 2 diabetes.

Cytokine 20090201

CE with direct sample injection for the determination of metformin in plasma for type 2 diabetic mellitus: An adequate alternative to HPLC.

Journal of separation science 20090201

Treatment of non-alcoholic fatty liver disease in children: swim at your own risk.

Pediatric diabetes 20090201

[Pharmacogenomics: inter-ethnic and intra-ethnic differences in pharmacokinetic and pharmacodynamic profiles of clinically relevant drugs].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20090201

Metabolic risks in older adults receiving second-generation antipsychotic medication.

Current psychiatry reports 20090201

Alogliptin: a new, highly selective dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes.

Expert opinion on pharmacotherapy 20090201

db/+ Mice as an alternate model in antidiabetic drug discovery research.

Archives of medical research 20090201

Drug evaluation: vildagliptin-metformin single-tablet combination.

Advances in therapy 20090201

Successful treatment of severe lactic acidosis caused by a suicide attempt with a metformin overdose.

The Kaohsiung journal of medical sciences 20090201

[Metformin in serum. Results of a study as basis for preliminary therapeutic recommendations].

Lakartidningen 20090201

[Optimisation of pharmacological therapy in a patient with a newly diagnosed type 2 diabetes].

Revue medicale de Liege 20090201

Adverse effect of pioglitazone in military personnel and their families: a preliminary report.

Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20090201

Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats.

Journal of ethnopharmacology 20090130

Follow-up of intensive glucose control in type 2 diabetes.

The New England journal of medicine 20090122

Follow-up of intensive glucose control in type 2 diabetes.

The New England journal of medicine 20090122

Follow-up of intensive glucose control in type 2 diabetes.

The New England journal of medicine 20090122

Metformin added to insulin therapy for type 1 diabetes mellitus in adolescents.

The Cochrane database of systematic reviews 20090121

Glucose control and vascular complications in veterans with type 2 diabetes.

The New England journal of medicine 20090108

Addition of biphasic insulin aspart 30 to optimized metformin and pioglitazone treatment of type 2 diabetes mellitus: The ACTION Study (Achieving Control Through Insulin plus Oral ageNts).

Diabetes, obesity & metabolism 20090101

Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERalpha negative MDA-MB-435 breast cancer model.

Breast cancer research and treatment 20090101

Do thiazide diuretics alter the pharmacokinetics of metformin in patients with type 2 diabetes already established on metformin?

British journal of clinical pharmacology 20090101

Efficacy of glimepiride/metformin combination versus glibenclamide/metformin in patients with uncontrolled type 2 diabetes mellitus.

Journal of diabetes and its complications 20090101

Insulin sensitizing drugs for weight loss in women of reproductive age who are overweight or obese: systematic review and meta-analysis.

Human reproduction update 20090101

Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD (liraglutide effect and action in diabetes)-2 study.

Diabetes care 20090101

Clinical and behavioral correlates of achieving and maintaining glycemic targets in an underserved population with type 2 diabetes.

Diabetes care 20090101

Clinical trial: pilot study of metformin for the treatment of non-alcoholic steatohepatitis.

Alimentary pharmacology & therapeutics 20090101

Mechanisms of metformin inhibiting lipolytic response to isoproterenol in primary rat adipocytes.

Journal of molecular endocrinology 20090101

Combined thiazolidinedione-metformin treatment synergistically improves insulin signalling to insulin receptor substrate-1-dependent phosphatidylinositol 3-kinase, atypical protein kinase C and protein kinase B/Akt in human diabetic muscle.

Diabetologia 20090101

Antiandrogenic contraceptives increase serum adiponectin in obese polycystic ovary syndrome patients.

Obesity (Silver Spring, Md.) 20090101

Efficacy and safety of exenatide in patients of Asian descent with type 2 diabetes inadequately controlled with metformin or metformin and a sulphonylurea.

Diabetes research and clinical practice 20090101

Treatment options for HIV-associated central fat accumulation.

AIDS patient care and STDs 20090101

Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management.

Hepatology (Baltimore, Md.) 20090101

Increased insulin sensitivity by metformin enhances intense-pulsed-light-assisted hair removal in patients with polycystic ovary syndrome.

Dermatology (Basel, Switzerland) 20090101

Enoxaparin-metformin and enoxaparin alone may safely reduce pregnancy loss.

Translational research : the journal of laboratory and clinical medicine 20090101

Benefits and risks of oral diabetes agents compared with insulin in women with gestational diabetes: a systematic review.

Obstetrics and gynecology 20090101

The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells.

Cell cycle (Georgetown, Tex.) 20090101

Efficacy and safety of adding the dipeptidyl peptidase-4 inhibitor alogliptin to metformin therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy: a multicentre, randomised, double-blind, placebo-controlled study.

International journal of clinical practice 20090101

Metformin maintains the weight loss and metabolic benefits following rimonabant treatment in obese women with polycystic ovary syndrome (PCOS).

Clinical endocrinology 20090101

Assessing the appropriate use of metformin in an inpatient setting and the effectiveness of two pharmacy-based measures to improve guideline adherence.

Quality management in health care 20090101

Identification of multidrug and toxin extrusion (MATE1 and MATE2-K) variants with complete loss of transport activity.

Journal of human genetics 20090101

Determinants of interleukin-6 and C-reactive protein vary in polycystic ovary syndrome, as do effects of short- and long-term metformin therapy.

Hormone research 20090101

A combination of grape seed-derived procyanidins and gypenosides alleviates insulin resistance in mice and HepG2 cells.

Journal of food science 20090101

Metformin treatment in diabetes and heart failure: when academic equipoise meets clinical reality.

Trials 20090101

Efficacy and safety of biphasic insulin aspart 70/30 versus exenatide in subjects with type 2 diabetes failing to achieve glycemic control with metformin and a sulfonylurea.

Current medical research and opinion 20090101

Hot flashes and fatigue relieved by metformin.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20090101

Hyperreninemia characterizing women with polycystic ovary syndrome improves after metformin therapy.

Kidney & blood pressure research 20090101

Should dialysis be offered in all cases of metformin-associated lactic acidosis?

Critical care (London, England) 20090101

Pioglitazone metabolic effect in metformin-intolerant obese patients treated with sibutramine.

Internal medicine (Tokyo, Japan) 20090101

Efficacy of metformin supplementation during ovarian stimulation of lean PCOS patients undergoing in vitro fertilization.

Acta obstetricia et gynecologica Scandinavica 20090101

Metformin in chemically-induced mammary carcinogenesis in rats.

Neoplasma 20090101

Metformin and lactic acidosis in patients with type 2 diabetes--from pride and prejudice to sense and sensibility.

Acta clinica Belgica 20090101

Diabetic cardiomyopathy: effects of fenofibrate and metformin in an experimental model--the Zucker diabetic rat.

Cardiovascular diabetology 20090101

[Application of numerical convolution in in vivo/in vitro correlation research].

Yao xue xue bao = Acta pharmaceutica Sinica 20090101

Column high-performance liquid chromatographic method for the simultaneous determination of rosiglitazone and metformin in a pharmaceutical preparation.

Journal of AOAC International 20090101

The ADDITION-Cambridge trial protocol: a cluster -- randomised controlled trial of screening for type 2 diabetes and intensive treatment for screen-detected patients.

BMC public health 20090101

The management of gestational diabetes.

Vascular health and risk management 20090101

PCOS.

BMJ clinical evidence 20090101

Impact of prandial plus basal vs basal insulin on glycemic variability in type 2 diabetic patients.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20090101

Soluble CD40 ligand, plasminogen activator inhibitor-1 and thrombin-activatable fibrinolysis inhibitor-1-antigen in normotensive type 2 diabetic subjects without diabetic complications. Effects of metformin and rosiglitazone.

Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20090101

beta cell protecting and immunomodulatory activities of Paecilomyces Hepiali Chen mycelium in STZ induced T1DM mice.

The American journal of Chinese medicine 20090101

[A clinical case of lactic acidosis development in a diabetic patient taking metformin].

Anesteziologiia i reanimatologiia 20090101

[Drug treatment of insulin resistance].

Revue medicale de Bruxelles 20090101

Metformin effects on clomifene-induced ovulation in the polycystic ovary syndrome.

La Tunisie medicale 20090101

Psychometric evaluation of the Diabetes Symptom Checklist-Revised (DSC-R)--a measure of symptom distress.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20090101

Rosiglitazone and myocardial infarction in patients previously prescribed metformin.

PloS one 20090101

Thiazolidinediones and cardiovascular events in patients with type 2 diabetes mellitus: a retrospective cohort study of over 473,000 patients using the National Health Insurance database in Taiwan.

Drug safety 20090101

The effect of ethinylestradiol (EE)/cyproterone acetate (CA) and EE/CA plus metformin treatment on adhesion molecules in cases with polycystic ovary syndrome (PCOS).

Internal medicine (Tokyo, Japan) 20090101

Evaluation of the repaglinide efficiency in comparison to the glimepiride in the type 2 diabetes patients poorly regulated by the metmorfine administration.

Bratislavske lekarske listy 20090101

Metformin plus pentoxifylline versus prescriptive diet in non-alcoholic steatohepatitis (NASH): a randomized controlled pilot trial.

Gastroenterologie clinique et biologique 20090101

[Effect of metformin on the clinical course of gout and insulin resistance].

Klinicheskaia meditsina 20090101

Mechanisms involved in metformin action in the treatment of polycystic ovary syndrome.

Current pharmaceutical design 20090101

Oral antidiabetic agents: anti-atherosclerotic properties beyond glucose lowering?

Current pharmaceutical design 20090101

An attempt at conservative treatment in selected cases of type I endometrial carcinoma (stage I a/G1) in young women.

European journal of gynaecological oncology 20090101

[Oral blood glucose-lowering medication as a monotherapy in gestational diabetes: a hotly debated topic].

Nederlands tijdschrift voor geneeskunde 20090101

Metformin in patients with non-alcoholic fatty liver disease: a randomized, controlled trial.

Scandinavian journal of gastroenterology 20090101

Beneficial effects of telmisartan in an HIV+ diabetic insulin-dependent patient.

International journal of immunopathology and pharmacology 20090101

Metformin, estrogen replacement therapy and gonadotropin inhibition fail to improve insulin sensitivity in a girl with aromatase deficiency.

Hormone research 20090101

What your doctor is reading.

Diabetes self-management 20090101

Combining insulin with metformin or an insulin secretagogue in non-obese patients with type 2 diabetes: 12 month, randomised, double blind trial.

BMJ (Clinical research ed.) 20090101

Lifestyle modification and metformin as long-term treatment options for obese adolescents: study protocol.

BMC public health 20090101

Risk of cardiovascular disease and all cause mortality among patients with type 2 diabetes prescribed oral antidiabetes drugs: retrospective cohort study using UK general practice research database.

BMJ (Clinical research ed.) 20090101

Leptin concentrations in patients with polycystic ovary syndrome before and after met-formin treatment depending on insulin resistance, body mass index and androgen con-centrations--introductory report.

Folia histochemica et cytobiologica 20090101

[Adipose tissue inflammation and atherosclerosis].

Kardiologiia 20090101

[Could oral antidiabetic agents be useful in the management of different types of diabetes and syndromes of insulin resistance in children and adolescents?].

Przeglad lekarski 20090101

Treatment with sitagliptin or metformin does not increase body weight despite predicted reductions in urinary glucose excretion.

Journal of diabetes science and technology 20090101

Optimising the medical management of hyperglycaemia in type 2 diabetes in the Middle East: pivotal role of metformin.

International journal of clinical practice 20090101

[Effects of the combined treatment with Metformin/Glimepiride on endothelial function of patients with type 2 diabetes mellitus. A positron emission tomography (PET) evaluation study].

Archivos de cardiologia de Mexico 20090101

How to explain a PaO2 of 140 mmHg in a venous line?

Acta bio-medica : Atenei Parmensis 20090101

Metformin and troglitazone in the treatment of female infertility associated with polycystic ovarian syndrome.

JNMA; journal of the Nepal Medical Association 20090101

[Metformin--an inhibitor of early stages of protein glycation].

Folia medica Cracoviensia 20090101

Use of bar coding technology to flag ER patients on metformin-containing drugs.

Radiology management 20090101

Metformin induces apoptosis of pancreatic cancer cells.

World journal of gastroenterology 20081221

Coagulanolide, a withanolide from Withania coagulans fruits and antihyperglycemic activity.

Bioorganic & medicinal chemistry letters 20081215

Changes in metformin pharmacokinetics after intravenous and oral administration to rats with short-term and long-term diabetes induced by streptozotocin.

Journal of pharmaceutical sciences 20081201

A comparison between rimonabant and metformin in reducing biochemical hyperandrogenaemia and insulin resistance in patients with polycystic ovary syndrome (PCOS): a randomized open-label parallel study.

Clinical endocrinology 20081201

Metformin increases fasting plasma peptide tyrosine tyrosine (PYY) in women with polycystic ovarian syndrome (PCOS).

Clinical endocrinology 20081201

Effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on beta-cell function in patients with type 2 diabetes: a model-based approach.

Diabetes, obesity & metabolism 20081201

Oral combination therapy: repaglinide plus metformin for treatment of type 2 diabetes.

Diabetes, obesity & metabolism 20081201

Effect of FeSO4 treatment on glucose metabolism in diabetic rats.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20081201

Efficacy and safety of vildagliptin monotherapy during 2-year treatment of drug-naïve patients with type 2 diabetes: comparison with metformin.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20081201

Short-term metabolic and cardiovascular effects of metformin in markedly obese adolescents with normal glucose tolerance.

Pediatric diabetes 20081201

Mechanisms of myocyte cytotoxicity induced by the multiple receptor tyrosine kinase inhibitor sunitinib.

Molecular pharmacology 20081201

Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro.

Toxicology and applied pharmacology 20081201

Prevention of diabetes in women with a history of gestational diabetes: effects of metformin and lifestyle interventions.

The Journal of clinical endocrinology and metabolism 20081201

Metformine for psychosis associated with the menstrual cycle in a patient with polycystic ovary syndrome.

Archives of women's mental health 20081201

Differences in effects of insulin glargine or pioglitazone added to oral anti-diabetic therapy in patients with type 2 diabetes: what to add--insulin glargine or pioglitazone?

Diabetes research and clinical practice 20081201

Risk of coronary artery disease associated with initial sulphonylurea treatment of patients with type 2 diabetes: a matched case-control study.

Diabetes research and clinical practice 20081201

Metformin regulates osteoblast and adipocyte differentiation of rat mesenchymal stem cells.

The Journal of pharmacy and pharmacology 20081201

Metformin and lactic acidosis.

British journal of anaesthesia 20081201

Clinical correlates of histopathology in pediatric nonalcoholic steatohepatitis.

Gastroenterology 20081201

Gestational diabetes: an opportunity for improvement.

The Journal of clinical endocrinology and metabolism 20081201

Insulin-lowering effects of metformin in women with early breast cancer.

Clinical breast cancer 20081201

PCOS and infertility.

Panminerva medica 20081201

Fast capillary electrophoresis coupled with time-of-flight mass spectrometry under separation conditions of high electrical field strengths.

The Analyst 20081201

Use of metformin in polycystic ovary syndrome.

American journal of obstetrics and gynecology 20081201

[Constitutional syndrome associated to metformin induced hepatotoxicity].

Gastroenterologia y hepatologia 20081201

Exenatide and acute pancreatitis.

The Journal of the Association of Physicians of India 20081201

Safety and efficacy of nateglinide/metformin combination therapy in the treatment of type 2 diabetes.

Vascular health and risk management 20081201

[Six-month effectiveness and tolerability of pioglitazone in combination with sulfonylureas or metformin for the treatment of type 2 diabetes mellitus].

Medicina clinica 20081129

Insulin resistance and fertility in polycystic ovary syndrome.

Journal of medicine and life 20081115

Metformin, but not pioglitazone, decreases postchallenge plasma ghrelin levels in type 2 diabetic patients: a possible role in weight stability?

Diabetes, obesity & metabolism 20081101

Genetic variants of the organic cation transporter 2 influence the disposition of metformin.

Clinical pharmacology and therapeutics 20081101

Stearoyl-coenzyme A desaturase 1 gene expression increases after pioglitazone treatment and is associated with peroxisomal proliferator-activated receptor-gamma responsiveness.

The Journal of clinical endocrinology and metabolism 20081101

[New therapies for type 2 diabetes: what place for incretin-based agents and rimonabant compared to the previous ones?].

La Revue de medecine interne 20081101

AICAR decreases the activity of two distinct amiloride-sensitive Na+-permeable channels in H441 human lung epithelial cell monolayers.

American journal of physiology. Lung cellular and molecular physiology 20081101

The impact of metformin, oral contraceptives, and lifestyle modification on polycystic ovary syndrome in obese adolescent women in two randomized, placebo-controlled clinical trials.

The Journal of clinical endocrinology and metabolism 20081101

Effects of pioglitazone and metformin on NEFA-induced insulin resistance in type 2 diabetes.

Diabetologia 20081101

The effects of pioglitazone and metformin on plasma visfatin levels in patients with treatment naive type 2 diabetes mellitus.

Diabetes research and clinical practice 20081101

Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysis.

Diabetes care 20081101

Metformin suppresses intestinal polyp growth in ApcMin/+ mice.

Cancer science 20081101

Hyperglycaemia secondary to mirtazapine therapy in a 37-year-old man.

The Australian and New Zealand journal of psychiatry 20081101

Current and emerging therapies in nonalcoholic fatty liver disease.

Seminars in liver disease 20081101

Rosiglitazone, but not glimepiride, improves myocardial diastolic function in association with reduction in oxidative stress in type 2 diabetic patients without overt heart disease.

Diabetes & vascular disease research 20081101

Impact of metformin, oral contraceptives, and lifestyle modification on polycystic ovary syndrome in obese adolescent women: do we need a new drug?

The Journal of clinical endocrinology and metabolism 20081101

Mechanisms of action of metformin in type 2 diabetes and associated complications: an overview.

Mini reviews in medicinal chemistry 20081101

Use of insulin-sensitizing agents in the treatment of polycystic ovary syndrome.

Fertility and sterility 20081101

Treatment of white coat hypertension with metformin.

International heart journal 20081101

[Safety of metformin in the treatment of elderly type 2 diabetes mellitus].

Zhonghua nei ke za zhi 20081101

Effectiveness and long-term safety of thiazolidinediones and metformin in renal transplant recipients.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20081101

Effects of basal insulin analog and metformin on glycaemia control and weight as risk factors for endothelial dysfunction.

Bosnian journal of basic medical sciences 20081101

Severe acanthosis nigricans in a 17 year-old female with partial lipodystrophic syndrome.

Journal of pediatric endocrinology & metabolism : JPEM 20081101

Metformin enhances the differentiation and mineralization of osteoblastic MC3T3-E1 cells via AMP kinase activation as well as eNOS and BMP-2 expression.

Biochemical and biophysical research communications 20081024

Summaries for patients. Comparison of two types of insulin added to diabetes pills in poorly controlled type 2 diabetes.

Annals of internal medicine 20081021

Addition of neutral protamine lispro insulin or insulin glargine to oral type 2 diabetes regimens for patients with suboptimal glycemic control: a randomized trial.

Annals of internal medicine 20081021

[Toxic metformin-associated acute pancreatitis without kidney failure].

Medicina clinica 20081018

[Initial therapy of diabetes mellitus in the family practice. Give yourself time!].

MMW Fortschritte der Medizin 20081016

Colesevelam hydrochloride therapy in patients with type 2 diabetes mellitus treated with metformin: glucose and lipid effects.

Archives of internal medicine 20081013

10-year follow-up of intensive glucose control in type 2 diabetes.

The New England journal of medicine 20081009

Association between hepatocellular carcinoma and type 2 diabetes mellitus in Italy: potential role of insulin.

World journal of gastroenterology 20081007

Effect of metformin pretreatment on pregnancy outcome of in vitro matured oocytes retrieved from women with polycystic ovary syndrome.

Fertility and sterility 20081001

Medication adherence and treatment success in the National Institute of Child Health and Human Development-Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial.

Fertility and sterility 20081001

Therapeutic response to metformin in an underweight patient with polycystic ovarian syndrome.

Fertility and sterility 20081001

Alteration of ghrelin-neuropeptide Y network in obese patients with polycystic ovary syndrome: role of hyperinsulinism.

Clinical endocrinology 20081001

Metformin and oral contraceptive treatments reduced circulating asymmetric dimethylarginine (ADMA) levels in patients with polycystic ovary syndrome (PCOS).

Atherosclerosis 20081001

Homeostasis model assessment-insulin resistance (HOMA-IR), a key role for assessing the ovulation function in polycystic ovary syndrome (PCOS) patients with insulin resistance.

Endocrine journal 20081001

Improvement of endothelial function with metformin and rosiglitazone treatment in women with polycystic ovary syndrome.

European journal of endocrinology 20081001

Cimetidine does not appear to influence the distribution of metformin into human milk.

British journal of clinical pharmacology 20081001

Transcellular transport of organic cations in double-transfected MDCK cells expressing human organic cation transporters hOCT1/hMATE1 and hOCT2/hMATE1.

Biochemical pharmacology 20081001

Metformin induces oxidative stress in white adipocytes and raises uncoupling protein 2 levels.

The Journal of endocrinology 20081001

Thiazolidinediones in type 2 diabetes: a cardiology perspective.

The Annals of pharmacotherapy 20081001

No effect of metformin on the innate airway hyperresponsiveness and increased responses to ozone observed in obese mice.

Journal of applied physiology (Bethesda, Md. : 1985) 20081001

First versus repeat treatment with a lifestyle intervention program: attendance and weight loss outcomes.

International journal of obesity (2005) 20081001

Metformin increases HDL3-cholesterol and decreases subcutaneous truncal fat in nondiabetic patients with HIV-associated lipodystrophy.

AIDS patient care and STDs 20081001

Janumet: a combination product suitable for use in patients with Type 2 diabetes.

Expert opinion on investigational drugs 20081001

Managing hyperglycaemia.

The British journal of general practice : the journal of the Royal College of General Practitioners 20081001

Does continuous use of metformin throughout pregnancy improve pregnancy outcomes in women with polycystic ovarian syndrome?

The journal of obstetrics and gynaecology research 20081001

A randomized, controlled trial of the effects of rosiglitazone on adipokines, and inflammatory and fibrinolytic markers in diabetic patients: study design and protocol.

The Canadian journal of cardiology 20081001

[Current evidence-based medicine for early intervention in diabetes].

Nihon rinsho. Japanese journal of clinical medicine 20081001

Metformin-responsive classic salt-losing congenital adrenal hyperplasia due to 21-hydroxylase deficiency: a case report.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20081001

[United Kingdom Prospective Diabetes Study (UKPDS): 10 years later].

Revue medicale de Liege 20081001

The effects of Diane-35 and metformin in treatment of polycystic ovary syndrome: an updated systematic review.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20081001

The effects of adiponectin and metformin on prostate and colon neoplasia involve activation of AMP-activated protein kinase.

Cancer prevention research (Philadelphia, Pa.) 20081001

Vildagliptin and vildagliptin/metformin: new drug. Same limited efficacy as sitagliptin in type 2 diabetes.

Prescrire international 20081001

Does metformin augment the ovulation inducing effects of clomiphene in non-obese women with polycystic ovary syndrome?

Journal of the Indian Medical Association 20081001

A 39-year-old man with HIV-associated lipodystrophy.

JAMA 20080903

Effects of metformin on peripheral insulin sensitivity and intracellular lipid contents in muscle and liver of overweight Japanese subjects.

Diabetes, obesity & metabolism 20080901

Weight changes in type 2 diabetes and the impact of gender.

Diabetes, obesity & metabolism 20080901

Effect of chronic rosiglitazone, metformin and glyburide treatment on beta-cell mass, function and insulin sensitivity in mZDF rats.

Diabetes, obesity & metabolism 20080901

Acute effect of metformin on exercise capacity in active males.

Diabetes, obesity & metabolism 20080901

Relationship between abnormal glucose tolerance test and history of previous recurrent miscarriages, and beneficial effect of metformin in these patients: a prospective clinical study.

Fertility and sterility 20080901

Effects of insulin resistance on endothelial function: possible mechanisms and clinical implications.

Diabetes, obesity & metabolism 20080901

Efficacy and safety of sitagliptin when added to ongoing metformin therapy in patients with type 2 diabetes.

Diabetes, obesity & metabolism 20080901

Potential benefits of early addition of rosiglitazone in combination with glimepiride in the treatment of type 2 diabetes.

Diabetes, obesity & metabolism 20080901

Metformin treatment of rats with diet-induced overweight and hypertriglyceridemia decreases plasma triglyceride concentrations, while decreasing triglyceride and increasing ketone body output by the isolated perfused liver.

Acta diabetologica 20080901

Metformin attenuates the stimulatory effect of a high-energy diet on in vivo LLC1 carcinoma growth.

Endocrine-related cancer 20080901

The effects of 8 months of metformin on circulating GGT and ALT levels in obese women with polycystic ovarian syndrome.

International journal of clinical practice 20080901

Metformin improves endothelial function in normoinsulinemic PCOS patients: a new prospective.

Human reproduction (Oxford, England) 20080901

Dehydroepiandrosterone and metformin modulate progesterone-induced blocking factor (PIBF), cyclooxygenase 2 (COX2) and cytokines in early pregnant mice.

The Journal of steroid biochemistry and molecular biology 20080901

Metformin normalizes endothelial function by suppressing vasoconstrictor prostanoids in mesenteric arteries from OLETF rats, a model of type 2 diabetes.

American journal of physiology. Heart and circulatory physiology 20080901

Strategies to control antipsychotic-induced weight gain.

Psychoneuroendocrinology 20080901

Effect of cationic drugs on the transporting activity of human and rat OCT/Oct 1-3 in vitro and implications for drug-drug interactions.

Xenobiotica; the fate of foreign compounds in biological systems 20080901

Effects of pioglitazone on serum fetuin-A levels in patients with type 2 diabetes mellitus.

Metabolism: clinical and experimental 20080901

Metabolic effects of various antidiabetic and hypolipidaemic agents on a high-fat diet and multiple low-dose streptozocin (MLDS) mouse model of diabetes.

The Journal of pharmacy and pharmacology 20080901

Cancer and aging: more puzzles, more promises?

Cell cycle (Georgetown, Tex.) 20080901

Clinical development of metformin extended-release tablets for type 2 diabetes: an overview.

Expert opinion on drug metabolism & toxicology 20080901

Monogenic polycystic ovary syndrome due to a mutation in the lamin A/C gene is sensitive to thiazolidinediones but not to metformin.

European journal of endocrinology 20080901

Metformin slows down aging and extends life span of female SHR mice.

Cell cycle (Georgetown, Tex.) 20080901

Genetic variants of organic cation transporter 2 (OCT2) significantly reduce metformin uptake in oocytes.

Xenobiotica; the fate of foreign compounds in biological systems 20080901

Physicochemical interactions of metformin hydrochloride and glibenclamide with several health foods.

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20080901

Considerations regarding the use of metformin with olanzapine.

The American journal of psychiatry 20080901

Olanzapine treatment and weight gain: considering the lipid side effects of antipsychotics.

The American journal of psychiatry 20080901

Pupillary autonomic neuropathy simulating partial Horner syndrome in diabetes mellitus and its reversal with control of blood glucose.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 20080901

Approach to the patient with prediabetes.

The Journal of clinical endocrinology and metabolism 20080901

Metformin: a multitasking medication.

Diabetes & vascular disease research 20080901

Metformin therapy and clinical uses.

Diabetes & vascular disease research 20080901

Improvement of glycaemic and lipid profiles with muraglitazar plus metformin in patients with type 2 diabetes: an active-control trial with glimepiride.

Diabetes & vascular disease research 20080901

Effect of metformin-containing antidiabetic regimens on all-cause mortality in veterans with type 2 diabetes mellitus.

The American journal of the medical sciences 20080901

[Effects of Yuquan pills on pharmacokinetics of metformin hydrochloride in diabetic rats].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080901

Addressing insulin resistance in Type 1 diabetes.

Diabetic medicine : a journal of the British Diabetic Association 20080901

[When oral therapy of type 2 diabetes fails--basal insulin is more effective than change in life style (interview by Dr. Thomas Meissner)].

MMW Fortschritte der Medizin 20080828

Association between oral antidiabetic use, adverse events and outcomes in patients with type 2 diabetes.

Diabetes, obesity & metabolism 20080801

Nateglinide, alone or in combination with metformin, is effective and well tolerated in treatment-naïve elderly patients with type 2 diabetes.

Diabetes, obesity & metabolism 20080801

Effect of homocysteine-lowering therapy on arterial elasticity and metabolic parameters in metformin-treated diabetic patients.

Atherosclerosis 20080801

Metformin, arterial function, intima-media thickness and nitroxidation in metabolic syndrome: the mefisto study.

Clinical and experimental pharmacology & physiology 20080801

Coronary heart disease outcomes in patients receiving antidiabetic agents in the PharMetrics database 2000-2007.

Pharmacoepidemiology and drug safety 20080801

Auto-immune neutropenia associated with metformin in a patient with splenic marginal zone lymphoma.

Pharmacy world & science : PWS 20080801

Mechanisms underlying saturable intestinal absorption of metformin.

Drug metabolism and disposition: the biological fate of chemicals 20080801

Is the combination of sulfonylureas and metformin associated with an increased risk of cardiovascular disease or all-cause mortality?: a meta-analysis of observational studies.

Diabetes care 20080801

Metformin inhibits intracellular lipid accumulation in the murine pre-adipocyte cell line, 3T3-L1.

Diabetes, obesity & metabolism 20080801

Does adding metformin to clomifene citrate lead to higher pregnancy rates in a subset of women with polycystic ovary syndrome?

Human reproduction (Oxford, England) 20080801

In vitro metformin anti-neoplastic activity in epithelial ovarian cancer.

Gynecologic oncology 20080801

Extended-release metformin does not reduce the clomiphene citrate dose required to induce ovulation in polycystic ovary syndrome.

The Journal of clinical endocrinology and metabolism 20080801

Metformin and the intestine.

Diabetologia 20080801

Dehydroepiandrosterone and metformin regulate proliferation of murine T lymphocytes.

Clinical and experimental immunology 20080801

Hyperbolic relationship between insulin secretion and sensitivity on oral glucose tolerance test.

Obesity (Silver Spring, Md.) 20080801

Heeding clues to metformin-associated lactic acidosis: prompt response can save life.

Emergency medicine journal : EMJ 20080801

Insulin-sensitizing agents and reproductive function in polycystic ovary syndrome patients.

Current opinion in obstetrics & gynecology 20080801

Reverse of progestin-resistant atypical endometrial hyperplasia by metformin and oral contraceptives.

Obstetrics and gynecology 20080801

Comparison of gene expression changes induced by biguanides in db/db mice liver.

The Journal of toxicological sciences 20080801

Is pharmacogenomics our future? Metformin, ovulation and polymorphism of the STK11 gene in polycystic ovary syndrome.

Pharmacogenomics 20080801

A randomized, double-blind, placebo-controlled trial of metformin treatment for weight gain associated with initiation of risperidone in children and adolescents.

Saudi medical journal 20080801

Metformin use in polycystic ovary syndrome: metabolic benefits and diabetes prevention.

The American journal of medicine 20080801

A study of the pharmacokinetic interactions of the direct renin inhibitor aliskiren with metformin, pioglitazone and fenofibrate in healthy subjects.

Current medical research and opinion 20080801

Insulin, insulin-like growth factors and neoplasia.

Best practice & research. Clinical endocrinology & metabolism 20080801

New combination treatments in the management of diabetes: focus on sitagliptin-metformin.

Vascular health and risk management 20080801

Metformin dispersible tablets: line extension. A welcome formulation of an essential drug.

Prescrire international 20080801

Mitochondrial respiratory complex I regulates neutrophil activation and severity of lung injury.

American journal of respiratory and critical care medicine 20080715

Targeting AMPK: a new therapeutic opportunity in breast cancer.

Critical reviews in oncology/hematology 20080701

Sex differences in diabetes risk and the effect of intensive lifestyle modification in the Diabetes Prevention Program.

Diabetes care 20080701

The effect of metformin treatment on VEGF and PAI-1 levels in obese type 2 diabetic patients.

Diabetes research and clinical practice 20080701

Adjust to target in type 2 diabetes: comparison of a simple algorithm with carbohydrate counting for adjustment of mealtime insulin glulisine.

Diabetes care 20080701

Serum uric acid concentration as non-classic cardiovascular risk factor in women with polycystic ovary syndrome: effect of treatment with ethinyl-estradiol plus cyproterone acetate versus metformin.

Human reproduction (Oxford, England) 20080701

Metformin-associated lactic acidosis in type 2 diabetes mellitus: incidence and presentation in common clinical practice.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20080701

Retinol-binding protein 4 and insulin resistance in polycystic ovary syndrome.

Diabetes care 20080701

Prevalence of risk determinants for metformin-associated lactic acidosis and metformin utilization in the study of health in pomerania.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20080701

Clinical trial: insulin-sensitizing agents may reduce consequences of insulin resistance in individuals with non-alcoholic steatohepatitis.

Alimentary pharmacology & therapeutics 20080701

Comparison of single and combined treatment with exenatide and metformin on menstrual cyclicity in overweight women with polycystic ovary syndrome.

The Journal of clinical endocrinology and metabolism 20080701

The effect of metformin on measurements of insulin sensitivity and beta cell response in 18 horses and ponies with insulin resistance.

Equine veterinary journal 20080701

Metformin induces cardioprotection against ischaemia/reperfusion injury in the rat heart 24 hours after administration.

Basic & clinical pharmacology & toxicology 20080701

Treatment options in insulin resistance obesity-related acanthosis nigricans.

The Annals of pharmacotherapy 20080701

Pharmacologic treatment options for prediabetes.

Nature clinical practice. Endocrinology & metabolism 20080701

Metformin in the treatment of infertility in polycystic ovarian syndrome: an alternative perspective.

Fertility and sterility 20080701

OCT2 polymorphisms and in-vivo renal functional consequence: studies with metformin and cimetidine.

Pharmacogenetics and genomics 20080701

Effects of swimming on the pharmacokinetics and glucose tolerance of metformin in insulin-resistant rats.

Biopharmaceutics & drug disposition 20080701

Adiponectin receptors: expression in Zucker diabetic rats and effects of fenofibrate and metformin.

Metabolism: clinical and experimental 20080701

An observational study of reduction of insulin resistance and prevention of development of type 2 diabetes mellitus in women with polycystic ovary syndrome treated with metformin and diet.

Metabolism: clinical and experimental 20080701

The risk of heart failure in patients with type 2 diabetes treated with oral agent monotherapy.

European journal of heart failure 20080701

Effects of metformin and ethinyl estradiol-cyproterone acetate on clinical, endocrine and metabolic factors in women with polycystic ovary syndrome.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20080701

A reappraisal of the role of polycystic ovary syndrome in recurrent miscarriage.

Reproductive biomedicine online 20080701

How does blood glucose control with metformin influence intensive insulin protocols? Evidence for involvement of oxidative stress and inflammatory cytokines.

Advances in therapy 20080701

Plasma cytokines in obese women with polycystic ovary syndrome, before and after metformin treatment.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20080701

Simultaneous estimation of metformin hydrochloride, pioglitazone hydrochloride, and glimepiride by RP-HPLC in tablet formulation.

Journal of chromatographic science 20080701

Organic cation transporters.

Xenobiotica; the fate of foreign compounds in biological systems 20080701

Metformin protects the brain against the oxidative imbalance promoted by type 2 diabetes.

Medicinal chemistry (Shariqah (United Arab Emirates)) 20080701

Adult metformin ingestions reported to Texas poison control centers, 2000-2006.

Human & experimental toxicology 20080701

Assessment of the efficacy and tolerability of a fixed dose combination of atorvastatin 10 mg + metformin SR 500 mg in diabetic dyslipidaemia in adult Indian patients.

Journal of the Indian Medical Association 20080701

Evidence for AMPK-dependent regulation of exocytosis of lipoproteins in a model liver cell line.

Experimental cell research 20080610

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level.

Oncogene 20080605

A 40-year-old woman with diabetes contemplating pregnancy after gastric bypass surgery.

JAMA 20080604

[Metformin role in the treatment of type 2 diabetes in 2008].

Revue medicale suisse 20080604

Rosiglitazone is more effective than metformin in improving fasting indexes of glucose metabolism in severely obese, non-diabetic patients.

Diabetes, obesity & metabolism 20080601

Antiretroviral therapy and the human immunodeficiency virus--improved survival but at what cost?

Diabetes, obesity & metabolism 20080601

The effect of pioglitazone as add-on therapy to metformin or sulphonylurea compared to a fixed-dose combination of metformin and glibenclamide on diabetic dyslipidaemia.

Nutrition, metabolism, and cardiovascular diseases : NMCD 20080601

AMP-activated protein kinase mediates glucocorticoid-induced metabolic changes: a novel mechanism in Cushing's syndrome.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080601

Metformin reverts deleterious effects of advanced glycation end-products (AGEs) on osteoblastic cells.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20080601

Metformin: effects on micro and macrovascular complications in type 2 diabetes.

Cardiovascular drugs and therapy 20080601

Interaction of oral antidiabetic drugs with hepatic uptake transporters: focus on organic anion transporting polypeptides and organic cation transporter 1.

Diabetes 20080601

Impact of metformin and rosiglitazone treatment on glucose transporter 4 mRNA expression in women with polycystic ovary syndrome.

European journal of endocrinology 20080601

Population exposure-response modeling of metformin in patients with type 2 diabetes mellitus.

Journal of clinical pharmacology 20080601

Metformin decreases the adipokine vaspin in overweight women with polycystic ovary syndrome concomitant with improvement in insulin sensitivity and a decrease in insulin resistance.

Diabetes 20080601

Metabolic actions of metformin in the heart can occur by AMPK-independent mechanisms.

American journal of physiology. Heart and circulatory physiology 20080601

Treatment of impaired glucose tolerance in childhood.

Nature clinical practice. Endocrinology & metabolism 20080601

Weight loss of black, white, and Hispanic men and women in the Diabetes Prevention Program.

Obesity (Silver Spring, Md.) 20080601

Glycaemic control and adverse events in patients with type 2 diabetes treated with metformin + sulphonylurea: a meta-analysis.

Diabetes, obesity & metabolism 20080601

Glycaemic control among patients with type 2 diabetes mellitus in seven European countries: findings from the Real-Life Effectiveness and Care Patterns of Diabetes Management (RECAP-DM) study.

Diabetes, obesity & metabolism 20080601

Hypoglycaemia in patients with type 2 diabetes treated with a combination of metformin and sulphonylurea therapy in France.

Diabetes, obesity & metabolism 20080601

Hypoglycaemic symptoms, treatment satisfaction, adherence and their associations with glycaemic goal in patients with type 2 diabetes mellitus: findings from the Real-Life Effectiveness and Care Patterns of Diabetes Management (RECAP-DM) Study.

Diabetes, obesity & metabolism 20080601

Development of a diabetes treatment simulation model: with application to assessing alternative treatment intensification strategies on survival and diabetes-related complications.

Diabetes, obesity & metabolism 20080601

Cost-effectiveness of sitagliptin-based treatment regimens in European patients with type 2 diabetes and haemoglobin A1c above target on metformin monotherapy.

Diabetes, obesity & metabolism 20080601

Effects of cross-link breakers, glycation inhibitors and insulin sensitisers on HDL function and the non-enzymatic glycation of apolipoprotein A-I.

Diabetologia 20080601

Acarbose for polycystic ovary syndrome.

The Annals of pharmacotherapy 20080601

Effect of food on the pharmacokinetics of a vildagliptin/metformin (50/1000 mg) fixed-dose combination tablet in healthy volunteers.

Current medical research and opinion 20080601

Role of metformin for weight management in patients without type 2 diabetes.

The Annals of pharmacotherapy 20080601

Effect of succinic acid monoethyl ester on hemoglobin glycation and tail tendon collagen properties in type 2 diabetic rats.

Fundamental & clinical pharmacology 20080601

Mecobalamin.

Expert opinion on investigational drugs 20080601

Metformin as a weight-loss tool in 'at-risk' obese adolescents: a magic bullet?

The Journal of pediatrics 20080601

Addition of metformin to a lifestyle modification program in adolescents with insulin resistance.

The Journal of pediatrics 20080601

Carrier-mediated transport of metformin across the human placenta determined by using the ex vivo perfusion of the placental cotyledon model.

Prenatal diagnosis 20080601

Type 2 diabetes: a well-characterised but suboptimally controlled disease. Can we bridge the divide?

Diabetes & metabolism 20080601

Thiazolidinedione addition reduces the serum retinol-binding protein 4 in type 2 diabetic patients treated with metformin and sulfonylurea.

Translational research : the journal of laboratory and clinical medicine 20080601

Drugs in infertility and fetal safety.

Fertility and sterility 20080601

Pharmacotherapy for obesity in menopausal women.

Menopause international 20080601

Metformin, B12 and homocysteine levels: the plausible cause or effect?

Journal of the Formosan Medical Association = Taiwan yi zhi 20080601

Metformin use in children with nonalcoholic fatty liver disease: an open-label, 24-month, observational pilot study.

Clinical therapeutics 20080601

[Effect of insulin plus rosiglitazone or metformin on serum N-terminal pro-brain natriuretic peptide in type 2 diabetes mellitus: a randomized-controlled study].

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20080601

[Incretin-mimetic drugs, an insulin alternative in type 2 diabetes].

Soins; la revue de reference infirmiere 20080601

[Non-alcoholic fatty liver disease--new view].

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20080601

Combination treatment in the management of type 2 diabetes: focus on vildagliptin and metformin as a single tablet.

Vascular health and risk management 20080601

Combining insulins with oral antidiabetic agents: effect on hyperglycemic control, markers of cardiovascular risk and disease.

Vascular health and risk management 20080601

Metformin plus sibutramine for olanzapine-associated weight gain and metabolic dysfunction in schizophrenia: a 12-week double-blind, placebo-controlled pilot study.

Psychiatry research 20080530

Capillary liquid chromatography and capillary electrochromatography using silica hydride stationary phases.

Journal of chromatography. A 20080516

Metformin for metabolic dysregulation in schizophrenic patients treated with olanzapine.

Progress in neuro-psychopharmacology & biological psychiatry 20080515

The antidiabetic effects of cysteinyl metformin, a newly synthesized agent, in alloxan- and streptozocin-induced diabetic rats.

Chemico-biological interactions 20080509

Metformin versus insulin for the treatment of gestational diabetes.

The New England journal of medicine 20080508

Gestational diabetes--setting limits, exploring treatments.

The New England journal of medicine 20080508

Effect of metformin on IGF-1 and IGFBP-1 levels in obese patients with polycystic ovary syndrome.

European journal of obstetrics, gynecology, and reproductive biology 20080501

Economic evaluation of the treatment of type 2 diabetes with insulin glargine based on the LAPTOP trial.

The European journal of health economics : HEPAC : health economics in prevention and care 20080501

Response to Pokharna and Kanna: initial treatment with rosiglitazone/metformin fixed-dose combination therapy compared with monotherapy with either rosiglitazone or metformin in patients with uncontrolled type 2 diabetes.

Diabetes, obesity & metabolism 20080501

Triplet pregnancy after metformin in a woman with polycystic ovary syndrome.

Fertility and sterility 20080501

Metformin treatment does not affect total leptin levels and free leptin index in obese patients with polycystic ovary syndrome.

Fertility and sterility 20080501

A systematic review of commonly used medical treatments for hirsutism in women.

Clinical endocrinology 20080501

Metformin protects the ischemic heart by the Akt-mediated inhibition of mitochondrial permeability transition pore opening.

Basic research in cardiology 20080501

Rosiglitazone-associated fractures in type 2 diabetes: an Analysis from A Diabetes Outcome Progression Trial (ADOPT).

Diabetes care 20080501

Impact of fixed-dose combination drugs on adherence to prescription medications.

Journal of general internal medicine 20080501

Metformin treatment for four years to reduce total and visceral fat in low birth weight girls with precocious pubarche.

The Journal of clinical endocrinology and metabolism 20080501

Establishing pragmatic estimated glomerular filtration rate thresholds to guide metformin prescribing: careful assessment of risks and benefits is required.

Diabetic medicine : a journal of the British Diabetic Association 20080501

Drug insight: insulin-sensitizing drugs in the treatment of polycystic ovary syndrome--a reappraisal.

Nature clinical practice. Endocrinology & metabolism 20080501

Rosiglitazone therapy improves insulin resistance parameters in overweight and obese diabetic patients intolerant to metformin.

Archives of medical research 20080501

Extended-release metformin in Asian patients.

International journal of clinical practice 20080501

The metabolic effects of once daily extended-release metformin in patients with type 2 diabetes: a multicentre study.

International journal of clinical practice 20080501

CB1 receptor blockade and its impact on cardiometabolic risk factors: overview of the RIO programme with rimonabant.

Journal of neuroendocrinology 20080501

Impact of metformin versus repaglinide on non-glycaemic cardiovascular risk markers related to inflammation and endothelial dysfunction in non-obese patients with type 2 diabetes.

European journal of endocrinology 20080501

Pubertal adiposity after fetal growth restraint: toward a calorie restriction mimetic approach.

Metabolism: clinical and experimental 20080501

Efficacy of berberine in patients with type 2 diabetes mellitus.

Metabolism: clinical and experimental 20080501

Psoriatic exacerbation associated with insulin therapy.

Diabetes care 20080501

Reality of severe metformin-induced lactic acidosis in the absence of chronic renal impairment.

The Netherlands journal of medicine 20080501

Bioequivalence of vildagliptin/metformin fixed-dose combination tablets and a free combination of vildagliptin and metformin in healthy subjects.

International journal of clinical pharmacology and therapeutics 20080501

[Metformin and kidneys].

Vnitrni lekarstvi 20080501

Metformin in polycystic ovary syndrome.

The New England journal of medicine 20080424

Metformin in polycystic ovary syndrome.

The New England journal of medicine 20080424

Metformin in polycystic ovary syndrome.

The New England journal of medicine 20080424

Metformin in polycystic ovary syndrome.

The New England journal of medicine 20080424

Antipsychotic-induced weight gain in patients with schizophrenia.

JAMA 20080423

Metformin and lactic acidosis in an Australian community setting: the Fremantle Diabetes Study.

The Medical journal of Australia 20080421

[Metformin should not be used by patients with reduced renal function].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20080417

Doctors seek to prevent breast cancer recurrence by lowering insulin levels.

Journal of the National Cancer Institute 20080416

Polycystic ovary syndrome.

Best practice & research. Clinical obstetrics & gynaecology 20080401

5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside reduces glucose uptake via the inhibition of Na+/H+ exchanger 1 in isolated rat ventricular cardiomyocytes.

Endocrinology 20080401

Adiponectin, change in adiponectin, and progression to diabetes in the Diabetes Prevention Program.

Diabetes 20080401

Pharmacokinetic interaction between DA-8159, a new erectogenic, and metformin in rats: competitive inhibition of metabolism via hepatic CYP3A1/2.

British journal of pharmacology 20080401

Clinical review: Antiandrogens for the treatment of hirsutism: a systematic review and metaanalyses of randomized controlled trials.

The Journal of clinical endocrinology and metabolism 20080401

Clinical review: Insulin sensitizers for the treatment of hirsutism: a systematic review and metaanalyses of randomized controlled trials.

The Journal of clinical endocrinology and metabolism 20080401

Attenuation of hypertension development by scavenging methylglyoxal in fructose-treated rats.

Journal of hypertension 20080401

The dipeptidyl peptidase-4 inhibitor PHX1149 improves blood glucose control in patients with type 2 diabetes mellitus.

Diabetes, obesity & metabolism 20080401

Glycaemic control in critically ill patients with myotonic dystrophy.

Anaesthesia 20080401

Use of metformin in polycystic ovary syndrome: a meta-analysis.

Obstetrics and gynecology 20080401

Dietary intervention versus metformin to improve the reproductive outcome in women with polycystic ovarian syndrome.

Saudi medical journal 20080401

Polymorphism in human organic cation transporters and metformin action.

Pharmacogenomics 20080401

Cellulose acetate microspheres as floating depot systems to increase gastric retention of antidiabetic drug: formulation, characterization and in vitro-in vivo evaluation.

Drug development and industrial pharmacy 20080401

Pretreatments before the induction of ovulation in assisted reproduction technologies: evidence-based medicine in 2007.

Annals of the New York Academy of Sciences 20080401

Resistin is expressed in human hepatocytes and induces insulin resistance.

Endocrine 20080401

[Metformin. Contraindications in heart failure reconsidered].

Medizinische Monatsschrift fur Pharmazeuten 20080401

Effects of metformin on QT and QTc interval dispersion of diabetic rats.

Arquivos brasileiros de cardiologia 20080401

Metformin: a review.

Drugs of today (Barcelona, Spain : 1998) 20080401

Use of metformin in obese adolescents with hyperinsulinemia: a 6-month, randomized, double-blind, placebo-controlled clinical trial.

Journal of pediatric endocrinology & metabolism : JPEM 20080401

Novel combination treatment of type 2 diabetes DPP-4 inhibition + metformin.

Vascular health and risk management 20080401

Metformin and lifestyle changes help people taking antipsychotics lose weight.

The Harvard mental health letter 20080401

Is the metabolic syndrome an intracellular Cushing state? Effects of multiple humoral factors on the transcriptional activity of the hepatic glucocorticoid-activating enzyme (11beta-hydroxysteroid dehydrogenase type 1) gene.

Molecular and cellular endocrinology 20080326

Diabetes specialists keep ACCORD data in perspective.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080315

Sitagliptin: a novel agent for the management of type 2 diabetes mellitus.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080315

[The effectiveness in type 2 diabetes prevention: a forced landing to reality].

Medicina clinica 20080308

AICAR induces astroglial differentiation of neural stem cells via activating the JAK/STAT3 pathway independently of AMP-activated protein kinase.

The Journal of biological chemistry 20080307

Examination of metformin hydrochloride in a continuous dissolution/HDM system.

International journal of pharmaceutics 20080303

C-reactive protein levels are unaffected by metformin during pretreatment and an IVF cycle in women with polycystic ovary syndrome.

Fertility and sterility 20080301

Prevention of gestational diabetes by metformin plus diet in patients with polycystic ovary syndrome.

Fertility and sterility 20080301

Effect of pioglitazone on heart function and N-terminal pro-brain natriuretic peptide levels of patients with type 2 diabetes.

Acta diabetologica 20080301

Ovulatory response to treatment of polycystic ovary syndrome is associated with a polymorphism in the STK11 gene.

The Journal of clinical endocrinology and metabolism 20080301

Erythromelalgia in a diabetic patient managed with gabapentin.

Diabetes research and clinical practice 20080301

Elevated depression symptoms, antidepressant medicine use, and risk of developing diabetes during the diabetes prevention program.

Diabetes care 20080301

Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS-mediated signaling.

Diabetes 20080301

Clinical predictors of disease progression and medication initiation in untreated patients with type 2 diabetes and A1C less than 7%.

Diabetes care 20080301

2-year effects of pioglitazone add-on to sulfonylurea or metformin on oral glucose tolerance in patients with type 2 diabetes.

Diabetes research and clinical practice 20080301

Therapeutic options for elderly diabetic subjects: open label, randomized clinical trial of insulin glargine added to oral antidiabetic drugs versus increased dosage of oral antidiabetic drugs.

Acta diabetologica 20080301

The effect of AMP-activated kinase activation on gonadotrophin-releasing hormone secretion in GT1-7 cells and its potential role in hypothalamic regulation of the oestrous cyclicity in rats.

Journal of neuroendocrinology 20080301

Association between use of thiazolidinediones or other oral antidiabetics and psoriasis: A population based case-control study.

Journal of the American Academy of Dermatology 20080301

Inhibition of glucokinase translocation by AMP-activated protein kinase is associated with phosphorylation of both GKRP and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

American journal of physiology. Regulatory, integrative and comparative physiology 20080301

Effects of exenatide versus insulin analogues on weight change in subjects with type 2 diabetes: a pooled post-hoc analysis.

Current medical research and opinion 20080301

Metformin addition attenuates olanzapine-induced weight gain in drug-naive first-episode schizophrenia patients: a double-blind, placebo-controlled study.

The American journal of psychiatry 20080301

Cardiovascular, metabolic and hormonal responses to the progressive exercise performed to exhaustion in patients with type 2 diabetes treated with metformin or glyburide.

Diabetes, obesity & metabolism 20080301

Does metformin improve polycystic ovary syndrome symptoms through reduction in body iron stores?

European journal of endocrinology 20080301

Consensus on infertility treatment related to polycystic ovary syndrome.

Human reproduction (Oxford, England) 20080301

Metformin does not suppress thyrotropin.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20080301

Artificially low HbA1c associated with treatment with ribavirin.

BMJ (Clinical research ed.) 20080301

[AMPK: a link between metabolism and reproduction?].

Medecine sciences : M/S 20080301

Outlook: metformin use in infertile patients with polycystic ovary syndrome: an evidence-based overview.

Reproductive biomedicine online 20080301

Formulation and in vitro studies of a fixed-dose combination of a bilayer matrix tablet containing metformin HCl as sustained release and glipizide as immediate release.

Drug development and industrial pharmacy 20080301

[Metformin and type-2 diabetes mellitus].

Atencion primaria 20080301

Cost-utility analysis of intensive blood glucose control with metformin versus usual care in overweight type 2 diabetes mellitus patients in Beijing, P.R. China.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20080301

Cost-effectiveness analysis of thiazolidinediones in uncontrolled type 2 diabetic patients receiving sulfonylureas and metformin in Thailand.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20080301

Beneficial effects of strategies for primary prevention of diabetes on cardiovascular risk factors: results of the Indian Diabetes Prevention Programme.

Diabetes & vascular disease research 20080301

Achieving glycosylated hemoglobin targets using the combination of repaglinide and metformin in type 2 diabetes: a reanalysis of earlier data in terms of current targets.

Clinical therapeutics 20080301

[Adjunctive therapies to glycaemic control of type 1 diabetes mellitus].

Arquivos brasileiros de endocrinologia e metabologia 20080301

[Lactic acidosis caused by metformin].

Anales de medicina interna (Madrid, Spain : 1984) 20080301

AMP-activated protein kinase subunit interactions: beta1:gamma1 association requires beta1 Thr-263 and Tyr-267.

The Journal of biological chemistry 20080222

Insulin in the adjuvant breast cancer setting: a novel therapeutic target for lifestyle and pharmacologic interventions?

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080220

Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells.

Circulation 20080219

Efficient delivery of siRNA using dendritic poly(L-lysine) for loss-of-function analysis.

Journal of controlled release : official journal of the Controlled Release Society 20080218

Clinical decisions. Management of type 2 diabetes--polling results.

The New England journal of medicine 20080214

[Insulin-using woman with type 2 diabetes and weight problems].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20080214

An overview of pancreatic beta-cell defects in human type 2 diabetes: implications for treatment.

Regulatory peptides 20080207

Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics.

Clinical pharmacology and therapeutics 20080201

Sustained-release matrix tablets of metformin hydrochloride in combination with triacetyl-beta-cyclodextrin.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20080201

Spatio-temporal expression patterns of aurora kinases a, B, and C and cytoplasmic polyadenylation-element-binding protein in bovine oocytes during meiotic maturation.

Biology of reproduction 20080201

Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP.

Diabetes 20080201

Impairment of the antioxidant properties of serum albumin in patients with diabetes: protective effects of metformin.

Clinical science (London, England : 1979) 20080201

Comparison of different drugs as add-on treatments to metformin in type 2 diabetes: a meta-analysis.

Diabetes research and clinical practice 20080201

Pioglitazone (7.5 mg/day) added to flutamide-metformin in women with androgen excess: additional increments of visfatin and high molecular weight adiponectin.

Clinical endocrinology 20080201

Management of type 2 diabetes in the obese patient: current concerns and emerging therapies.

Current medical research and opinion 20080201

Sitagliptin, a DPP-4 inhibitor for the treatment of patients with type 2 diabetes: a review of recent clinical trials.

Current medical research and opinion 20080201

The ratio of leptin to adiponectin can be used as an index of insulin resistance.

Metabolism: clinical and experimental 20080201

Efficacy and safety of sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes.

Current medical research and opinion 20080201

The investigation and management of severe hyperandrogenism pre- and postmenopause: non-tumor disease is strongly associated with metabolic syndrome and typically responds to insulin-sensitization with metformin.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20080201

STOPP (Screening Tool of Older Person's Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment). Consensus validation.

International journal of clinical pharmacology and therapeutics 20080201

High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase.

Hepatology (Baltimore, Md.) 20080201

Type 2 diabetes mellitus and heart failure.

Pharmacotherapy 20080201

Optimizing antidiabetic treatment options for patients with type 2 diabetes mellitus and cardiovascular comorbidities.

Pharmacotherapy 20080201

Combined therapy with insulin plus oral agents: is there any advantage? An argument in favor.

Diabetes care 20080201

Treatment of type 2 diabetes with combined therapy: what are the pros and cons?

Diabetes care 20080201

Insulin as a first-line therapy in type 2 diabetes: should the use of sulfonylureas be halted?

Diabetes care 20080201

The nuts and bolts of achieving end points with real-time continuous glucose monitoring.

Diabetes care 20080201

Effects of cysteine on metformin pharmacokinetics in rats with protein-calorie malnutrition: partial restoration of some parameters to control levels.

The Journal of pharmacy and pharmacology 20080201

Optimization of metformin HCl 500 mg sustained release matrix tablets using Artificial Neural Network (ANN) based on Multilayer Perceptrons (MLP) model.

Chemical & pharmaceutical bulletin 20080201

Metformin-associated lactic acidosis following contrast media-induced nephrotoxicity.

European journal of anaesthesiology 20080201

Metformin-induced lactic acidosis and acute pancreatitis precipitated by diuretic, celecoxib, and candesartan-associated acute kidney dysfunction.

Clinical toxicology (Philadelphia, Pa.) 20080201

Meta-analysis: metformin treatment in persons at risk for diabetes mellitus.

The American journal of medicine 20080201

Oral antidiabetic medication adherence and glycemic control in managed care.

The American journal of managed care 20080201

Ovulation induction in polycystic ovary syndrome.

Minerva ginecologica 20080201

Medical therapy in women with polycystic ovarian syndrome before and during pregnancy and lactation.

Minerva ginecologica 20080201

Role of metformin in patients with polycystic ovary syndrome: the state of the art.

Minerva ginecologica 20080201

A retrospective analysis of the fasting plasma glucose and glycosylated hemoglobin and pharmacotherapy change patterns among type 2 diabetes mellitus patients.

Clinical therapeutics 20080201

[Metformin and AMPK: an old drug and a new enzyme in the context of metabolic syndrome].

Arquivos brasileiros de endocrinologia e metabologia 20080201

Impact of metformin on peak aerobic capacity.

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 20080201

Sitagliptin: new drug. Type 2 diabetes: limited efficacy, too many unknown risks.

Prescrire international 20080201

The use of metformin as first line treatment in polycystic ovary syndrome.

Irish medical journal 20080201

Therapeutic approach of type 2 diabetes mellitus with GLP-1 based therapies.

Diabetes & metabolism 20080201

DPP-4 inhibitors and GLP-1 analogues: for whom? Which place for incretins in the management of type 2 diabetic patients?

Diabetes & metabolism 20080201

Long versus short course treatment with Metformin and Clomiphene Citrate for ovulation induction in women with PCOS.

The Cochrane database of systematic reviews 20080123

Clinical decisions. Management of type 2 diabetes.

The New England journal of medicine 20080117

Lifestyle intervention and metformin for treatment of antipsychotic-induced weight gain: a randomized controlled trial.

JAMA 20080109

HPLC-UV determination of metformin in human plasma for application in pharmacokinetics and bioequivalence studies.

Journal of pharmaceutical and biomedical analysis 20080107

Metformin for the treatment of the polycystic ovary syndrome.

The New England journal of medicine 20080103

Determination of metformin transfer across the human placenta using a dually perfused ex vivo placental cotyledon model.

European journal of obstetrics, gynecology, and reproductive biology 20080101

Medication use and disease management of type 2 diabetes in Belgium.

Pharmacy world & science : PWS 20080101

Metformin and body weight.

International journal of obesity (2005) 20080101

Safety and efficacy of repaglinide in combination with metformin and bedtime NPH insulin as an insulin treatment regimen in type 2 diabetes.

Diabetes research and clinical practice 20080101

High and typical 18F-FDG bowel uptake in patients treated with metformin.

European journal of nuclear medicine and molecular imaging 20080101

Metformin promotes isolated rat liver mitochondria impairment.

Molecular and cellular biochemistry 20080101

Comparison of the effects of pioglitazone and metformin on hepatic and extra-hepatic insulin action in people with type 2 diabetes.

Diabetes 20080101

Decreased in vivo oxidative stress and decreased platelet activation following metformin treatment in newly diagnosed type 2 diabetic subjects.

Diabetes/metabolism research and reviews 20080101

Why insulin sensitizers but not secretagogues should be retained when initiating insulin in type 2 diabetes.

Diabetes/metabolism research and reviews 20080101

Efficacy and treatment satisfaction of once-daily insulin glargine plus one or two oral antidiabetic agents versus continuing premixed human insulin in patients with Type 2 diabetes previously on long-term conventional insulin therapy: the SWITCH Pilot Study.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20080101

Asymmetrical dimethylarginine, inflammatory and metabolic parameters in women with polycystic ovary syndrome before and after metformin treatment.

The Journal of clinical endocrinology and metabolism 20080101

Efficacy and tolerability of vildagliptin vs. pioglitazone when added to metformin: a 24-week, randomized, double-blind study.

Diabetes, obesity & metabolism 20080101

Neuroprotective role of antidiabetic drug metformin against apoptotic cell death in primary cortical neurons.

Journal of molecular neuroscience : MN 20080101

Lowering the threshold for defining microalbuminuria: effects of a lifestyle-metformin intervention in obese 'normoalbuminuric' non-diabetic subjects.

American journal of hypertension 20080101

Increased hematocrit and reduced blood pressure following control of glycemia in diabetes.

Clinical hemorheology and microcirculation 20080101

Comparison of fixed-dose rosiglitazone/metformin combination therapy with sulphonylurea plus metformin in overweight individuals with Type 2 diabetes inadequately controlled on metformin alone.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20080101

Metformin-associated lactic acidosis in patients with renal impairment solely due to drug accumulation?

Diabetes, obesity & metabolism 20080101

Glucose lowering treatment in patients with coronary artery disease is prognostically important not only in established but also in newly detected diabetes mellitus: a report from the Euro Heart Survey on Diabetes and the Heart.

European heart journal 20080101

The impact of glucose lowering treatment on long-term prognosis in patients with type 2 diabetes and myocardial infarction: a report from the DIGAMI 2 trial.

European heart journal 20080101

Pioglitazone and metformin for increased small low-density lipoprotein in polycystic ovary syndrome: counterpoint.

American journal of obstetrics and gynecology 20080101

Impact of metformin versus the prandial insulin secretagogue, repaglinide, on fasting and postprandial glucose and lipid responses in non-obese patients with type 2 diabetes.

European journal of endocrinology 20080101

Polycystic ovarian syndrome, biomarkers, and metformin: research, risk, and reality.

The Journal of clinical endocrinology and metabolism 20080101

Functional involvement of the organic cation transporter 2 (rOct2) in the renal uptake of organic cations in rats.

The Journal of international medical research 20080101

Metformin in therapy naive patients with polycystic ovary syndrome.

Human reproduction update 20080101

Emerging concepts in the medical and surgical treatment of obesity.

Frontiers of hormone research 20080101

Non-insulin antidiabetic therapy in cardiac patients: current problems and future prospects.

Advances in cardiology 20080101

Choosing first-line therapy for management of type 2 diabetes.

American family physician 20080101

Estimating the long-term cost-effectiveness of exenatide in the United States: an adjunctive treatment for type 2 diabetes mellitus.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20080101

Acne in adult women.

Skinmed 20080101

[The possibility of prevention of type 2 diabetes].

Endokrynologia Polska 20080101

Serum transforming growth factor-beta 1 levels in normoalbuminuric and normotensive patients with type 2 diabetes. Effect of metformin and rosiglitazone.

Hormones (Athens, Greece) 20080101

Metformin: effective and safe in renal disease?

International urology and nephrology 20080101

Effects of Persea americana Mill (Lauraceae) ['Avocado'] ethanolic leaf extract on blood glucose and kidney function in streptozotocin-induced diabetic rats and on kidney cell lines of the proximal (LLCPK1) and distal tubules (MDBK).

Methods and findings in experimental and clinical pharmacology 20080101

Re: 'Effect of metformin and rosiglitazone in a prepubertal boy with Alström syndrome', Sinha SK et al., JPEM 2007; 20: 1045-1052.

Journal of pediatric endocrinology & metabolism : JPEM 20080101

An overview of obesity in children with psychiatric disorders taking atypical antipsychotics.

Harvard review of psychiatry 20080101

Pediatric obesity: parallels with addiction and treatment recommendations.

Harvard review of psychiatry 20080101

Metformin and parameters of physical health.

Internal medicine (Tokyo, Japan) 20080101

[Efficacy and safety of the use of metformin in patients with chronic heart failure and type 2 diabetes mellitus. results of the study 'rational effective mulicomponent therapy in the battle against diabetes mellitus in patients with chronic heart failure'].

Kardiologiia 20080101

Effect of the addition of rosiglitazone to metformin or sulfonylureas versus metformin/sulfonylurea combination therapy on ambulatory blood pressure in people with type 2 diabetes: a randomized controlled trial (the RECORD study).

Cardiovascular diabetology 20080101

Effects of diabetes mellitus induced by alloxan on the pharmacokinetics of metformin in rats: restoration of pharmacokinetic parameters to the control state by insulin treatment.

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20080101

Metformin-induced lactic acidosis in a type 2 diabetic patient with acute renal failure.

La Clinica terapeutica 20080101

Metformin-associated lactic acidosis in a pregnant patient.

Gynecologic and obstetric investigation 20080101

A comparison of select cardiovascular outcomes by antidiabetic prescription drug classes used to treat type 2 diabetes among Military Health System beneficiaries, fiscal year 2003-2006.

American journal of therapeutics 20080101

Metformin reduces cellular lysophosphatidylcholine and thereby may lower apolipoprotein B secretion in primary human hepatocytes.

Biochimica et biophysica acta 20080101

[Metformin therapy in polycystic ovary syndrome].

Ginekologia polska 20080101

Scutellaria baicalensis enhances the anti-diabetic activity of metformin in streptozotocin-induced diabetic Wistar rats.

The American journal of Chinese medicine 20080101

[Multiple risk factors and drug interactions leading to severe lactic acidosis].

Therapie 20080101

Improvement of autoimmune hypoglycemia by decreasing circulating free insulin concentrations with metformin.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20080101

Intensification of oxidative stress and inflammation in type 2 diabetes despite antihyperglycemic treatment.

Cardiovascular diabetology 20080101

Evaluation of adverse events of oral antihyperglycemic monotherapy experienced by a geriatric population in a real-world setting: a retrospective cohort analysis.

Drugs & aging 20080101

Effects of pretreatment with low-dose metformin on metabolic parameters and weight gain by pioglitazone in Japanese patients with type 2 diabetes.

Internal medicine (Tokyo, Japan) 20080101

Haemoglobin A1c goal attainment in relation to dose in patients with diabetes mellitus taking metformin: a nested, case-control study.

Clinical drug investigation 20080101

[Metformin in the clinical practice. Polish Society of Endocrinology consensus based on the European and American medical societies].

Endokrynologia Polska 20080101

Homeostasis model assessment (HOMA) as surrogate insulinization criteria in patients with type 2 diabetes.

American journal of therapeutics 20080101

Metformin has no major effects on glucose homeostasis in pregnant women with PCOS: results of a randomized double-blind study.

Scandinavian journal of clinical and laboratory investigation 20080101

Fixed-dose combination tablet of repaglinide and metformin is bioequivalent to concomitantly administered individual tablets of repaglinide and metformin : randomized, single-blind, three-period crossover study in healthy subjects.

Clinical drug investigation 20080101

Metformin in the treatment of polycystic ovary syndrome.

Current pharmaceutical design 20080101

Insulin resistance postburn: underlying mechanisms and current therapeutic strategies.

Journal of burn care & research : official publication of the American Burn Association 20080101

Performing meta-analysis with incomplete statistical information in clinical trials.

BMC medical research methodology 20080101

Metformin use in decompensated heart failure.

Cardiology in review 20080101

Organic cation transporters and their pharmacokinetic and pharmacodynamic consequences.

Drug metabolism and pharmacokinetics 20080101

Metformin Trumps insulin in the treatment of gestational diabetes.

Medscape journal of medicine 20080101

Desaturase activities and metabolic control in type 2 diabetes.

Prostaglandins, leukotrienes, and essential fatty acids 20080101

Quality of diabetes care among patients managed by teleconsultation.

Journal of telemedicine and telecare 20080101

Insulin resistance: a potential new target for therapy in patients with heart failure.

Cardiovascular therapeutics 20080101

Undiagnosed type 2 diabetes mellitus presenting with orbital cellulitis.

Orbit (Amsterdam, Netherlands) 20080101

Metformin: effective in the prevention of new-onset type 2 diabetes?

Progress in cardiovascular nursing 20080101

Effect of adjunct metformin treatment in patients with type-1 diabetes and persistent inadequate glycaemic control. A randomized study.

PloS one 20080101

Outcomes of adding second hypoglycemic drug after metformin monotherapy failure among type 2 diabetes in Hungary.

Health and quality of life outcomes 20080101

[Used of oral antidiabetic agents in pediatric patients - own observations].

Endokrynologia Polska 20080101

Metformin-associated lactic acidosis in an intensive care unit.

Critical care (London, England) 20080101

Antidiabetic and antioxidant activities of major flavonoids of Cynanchum acutum L. (Asclepiadaceae) growing in Egypt.

Zeitschrift fur Naturforschung. C, Journal of biosciences 20080101

Estradiol-to-testosterone ratio is associated with response to metformin treatment in women with clomiphene citrate-resistant polycystic ovary syndrome (PCOS).

Chang Gung medical journal 20080101

[Avandia and avandamet in the treatment of patients with diabetes mellitus type 2: effects on secretion of some fat tissue hormones].

Terapevticheskii arkhiv 20080101

Alterations of coagulation in metformin intoxication.

Hormones (Athens, Greece) 20080101

[Suggestions for prevention of adverse reactions after intravasal administration of iodinated contrast media].

Rontgenpraxis; Zeitschrift fur radiologische Technik 20080101

Combined treatment of intrapancreatic autologous bone marrow stem cells and hyperbaric oxygen in type 2 diabetes mellitus.

Cell transplantation 20080101

Identification and treatment of prediabetes to prevent progression to type 2 diabetes.

Clinical cornerstone 20080101

Diabetes: glycaemic control in type 2.

BMJ clinical evidence 20080101

Contraindications to metformin therapy among patients with type 2 diabetes mellitus.

Pharmacy world & science : PWS 20071201

Pioglitazone: an anti-diabetic compound with anti-aging properties.

Biogerontology 20071201

The effects of metformin on metabolic and cardiovascular risk factors in nonobese women with polycystic ovary syndrome.

Clinical endocrinology 20071201

Effect of metformin on clastogenic and biochemical changes induced by adriamycin in Swiss albino mice.

Mutation research 20071201

Comparison of insulin monotherapy and combination therapy with insulin and metformin or insulin and rosiglitazone or insulin and acarbose in type 2 diabetes.

Acta diabetologica 20071201

Oxidative stress and endothelium influenced by metformin in type 2 diabetes mellitus.

European journal of clinical pharmacology 20071201

Effects of tetraalkylammonium compounds with different affinities for organic cation transporters on the pharmacokinetics of metformin.

Biopharmaceutics & drug disposition 20071201

The Pro12Ala variant at the peroxisome proliferator-activated receptor gamma gene and change in obesity-related traits in the Diabetes Prevention Program.

Diabetologia 20071201

Use of insulin sensitizers in NASH.

Endocrinology and metabolism clinics of North America 20071201

Polycystic ovarian syndrome--prognosis and treatment outcomes.

Current opinion in obstetrics & gynecology 20071201

Metformin therapy in patients with type 2 diabetes complicated by heart failure.

American heart journal 20071201

[Overdose of metformin secondary to acute renal insufficiency: a report of six cases].

Medicina intensiva 20071201

Use of metformin according to estimated glomerular filtration rate: the threshold and the equation are important.

Diabetic medicine : a journal of the British Diabetic Association 20071201

Estimated glomerular filtration rate (eGFR) and metformin.

Diabetic medicine : a journal of the British Diabetic Association 20071201

Metformin in heart failure.

Diabetes care 20071201

Non-surgical interventions for threatened and recurrent miscarriages.

Singapore medical journal 20071201

DPP-4 inhibitors.

Best practice & research. Clinical endocrinology & metabolism 20071201

Metformin discontinuation rate among patients with type-2 diabetes mellitus in Basrah, Iraq.

Saudi medical journal 20071201

Effect of rosiglitazone and metformin on insulin resistance in patients infected with human immunodeficiency virus receiving highly active antiretroviral therapy containing protease inhibitor: randomized prospective controlled clinical trial.

Croatian medical journal 20071201

Metformin decreases circulating acylation-stimulating protein levels in polycystic ovary syndrome.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20071201

Blurred vision.

The Netherlands journal of medicine 20071201

[Inflammation, atherosclerosis, classic cardiovascular risk factors, biostatistics, clinical significance. Where are we?].

Revista espanola de cardiologia 20071201

[Rosuvastatin and metformin decrease inflammation and oxidative stress in patients with hypertension and dyslipidemia].

Revista espanola de cardiologia 20071201

Exenatide: new drug. Type 2 diabetes for some overweight patients.

Prescrire international 20071201

Cardiovascular risk in women with polycystic ovary syndrome.

Minerva endocrinologica 20071201

Insulin glargine added to therapy with oral antidiabetic agents improves glycemic control and reduces long-term complications in patients with type 2 diabetes - a simulation with the Diabetes Mellitus Model (DMM).

International journal of clinical pharmacology and therapeutics 20071201

A review of thiazolidinediones and metformin in the treatment of type 2 diabetes with focus on cardiovascular complications.

Vascular health and risk management 20071201

Clinical management strategies for type 2 diabetes.

JAAPA : official journal of the American Academy of Physician Assistants 20071201

The nurse's role in discouraging clinical inertia in diabetes management: optimizing cardiovascular health among African-Americans.

Journal of National Black Nurses' Association : JNBNA 20071201

Pharmacotherapy for obesity.

Current atherosclerosis reports 20071201

Incretin enhancers and the evolution of antihyperglycemic therapy in type 2 diabetes.

Endocrinology and metabolism clinics of North America 20071201

Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells.

Cancer research 20071115

Physical-chemical characterization of binary systems of metformin hydrochloride with triacetyl-beta-cyclodextrin.

Journal of pharmaceutical and biomedical analysis 20071105

Letter to the editor in reference to article titled: Initial treatment with rosiglitazone/metformin fixed-dose combination therapy compared with monotherapy with either rosiglitazone or metformin in patients with uncontrolled type 2 diabetes.

Diabetes, obesity & metabolism 20071101

When a friend can become an enemy! Recognition and management of metformin-associated lactic acidosis.

Kidney international 20071101

Medical therapy for diabetes is associated with increased use of lower endoscopy.

Pharmacoepidemiology and drug safety 20071101

Maternal diabetes adversely affects AMP-activated protein kinase activity and cellular metabolism in murine oocytes.

American journal of physiology. Endocrinology and metabolism 20071101

A central role for neuronal adenosine 5'-monophosphate-activated protein kinase in cancer-induced anorexia.

Endocrinology 20071101

Efficacy of metformin in obese and non-obese women with polycystic ovary syndrome: a randomized, double-blinded, placebo-controlled cross-over trial.

Human reproduction (Oxford, England) 20071101

Lactate levels in Asian patients with type 2 diabetes mellitus on metformin and its association with dose of metformin and renal function.

International journal of clinical practice 20071101

Normalization of metabolic syndrome using fenofibrate, metformin or their combination.

Diabetes, obesity & metabolism 20071101

Dietary intervention versus metformin to improve the reproductive outcome in women with polycystic ovary syndrome. A prospective comparative study.

Saudi medical journal 20071101

Anti-diabetic effects of compound K versus metformin versus compound K-metformin combination therapy in diabetic db/db mice.

Biological & pharmaceutical bulletin 20071101

Flutamide metformin for post-menarcheal girls with preclinical ovarian androgen excess: evidence for differential response by androgen receptor genotype.

European journal of endocrinology 20071101

Metformin improves polycystic ovary syndrome symptoms irrespective of pre-treatment insulin resistance.

European journal of endocrinology 20071101

Glycemic response to newly initiated diabetes therapies.

The American journal of managed care 20071101

Improved meal-related insulin processing contributes to the enhancement of B-cell function by the DPP-4 inhibitor vildagliptin in patients with type 2 diabetes.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20071101

FPIN's clinical inquiries. Metformin therapy and diabetes prevention in adolescents who are obese.

American family physician 20071101

Effect of biphasic insulin aspart 30 combined with metformin on glycaemic control in obese people with type 2 diabetes.

Bosnian journal of basic medical sciences 20071101

Rosiglitazone improves endothelial function and inflammation but not asymmetric dimethylarginine or oxidative stress in patients with type 2 diabetes mellitus.

Vascular medicine (London, England) 20071101

Efficacy and treatment satisfaction of once-daily insulin glargine plus one or two oral antidiabetic agents versus continuing premixed human insulin in patients with type 2 diabetes previously on long-term conventional insulin therapy: the Switch pilot study.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20071101

Effect of glyburide-metformin combination tablet in patients with type 2 diabetes.

Journal of the Chinese Medical Association : JCMA 20071101

[New data on hypoglycemia risk and beta cell function].

MMW Fortschritte der Medizin 20071101

Tolerability and efficacy of exenatide and titrated insulin glargine in adult patients with type 2 diabetes previously uncontrolled with metformin or a sulfonylurea: a multinational, randomized, open-label, two-period, crossover noninferiority trial.

Clinical therapeutics 20071101

Mealtime 50/50 basal + prandial insulin analogue mixture with a basal insulin analogue, both plus metformin, in the achievement of target HbA1c and pre- and postprandial blood glucose levels in patients with type 2 diabetes: a multinational, 24-week, randomized, open-label, parallel-group comparison.

Clinical therapeutics 20071101

Comparison of biphasic insulin aspart 30 given three times daily or twice daily in combination with metformin versus oral antidiabetic drugs alone in patients with poorly controlled type 2 diabetes: a 16-week, randomized, open-label, parallel-group trial conducted in russia.

Clinical therapeutics 20071101

Metformin and insulin in the management of gestational diabetes mellitus: preliminary results of a comparison.

The Journal of reproductive medicine 20071101

[Blood pressure and type 2 diabetes mellitus: impact of the insulin therapy].

La Tunisie medicale 20071101

Addition of biphasic, prandial, or basal insulin to oral therapy in type 2 diabetes.

The New England journal of medicine 20071025

Direct determination of metformin in urine by adsorptive catalytic square-wave voltammetry.

Journal of pharmaceutical and biomedical analysis 20071018

Activation of mammalian target of rapamycin complex 1 and insulin resistance induced by palmitate in hepatocytes.

Biochemical and biophysical research communications 20071012

Effect of metformin on serum lipoprotein lipase mass levels and LDL particle size in type 2 diabetes mellitus patients.

Diabetes research and clinical practice 20071001

Evaluation of endothelial function in women with polycystic ovary syndrome.

European journal of obstetrics, gynecology, and reproductive biology 20071001

A comparison of mealtime insulin aspart and human insulin in combination with metformin in type 2 diabetes patients.

Diabetes research and clinical practice 20071001

Metformin transport by a newly cloned proton-stimulated organic cation transporter (plasma membrane monoamine transporter) expressed in human intestine.

Drug metabolism and disposition: the biological fate of chemicals 20071001

Effects of water deprivation on the pharmacokinetics of metformin in rats.

Biopharmaceutics & drug disposition 20071001

Establishing pragmatic estimated GFR thresholds to guide metformin prescribing.

Diabetic medicine : a journal of the British Diabetic Association 20071001

A randomized placebo-controlled trial of metformin for the treatment of HIV lipodystrophy.

HIV medicine 20071001

beta-cell function and anti-diabetic pharmacotherapy.

Diabetes/metabolism research and reviews 20071001

Effects of pioglitazone and metformin on intracellular lipid content in liver and skeletal muscle of individuals with type 2 diabetes mellitus.

Metabolism: clinical and experimental 20071001

A comment on 'the risk of coronary heart disease in type 2 diabetic patients exposed to thiazolidinediones compared to metformin and sulfonylurea therapy'.

Pharmacoepidemiology and drug safety 20071001

Adipose tissue and diabetes therapy: do we hit the target?

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20071001

Novel endocrine disrupter effects of classic and atypical antipsychotic agents and divalproex: induction of adrenal hyperandrogenism, reversible with metformin or rosiglitazone.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20071001

Risk of multiple gestation after ovulation induction in polycystic ovary syndrome.

The Journal of reproductive medicine 20071001

Sitagliptin with metformin: profile of a combination for the treatment of type 2 diabetes.

Drugs of today (Barcelona, Spain : 1998) 20071001

[Clinical study on effect of Bushen Huayu Qutan Recipe in treating polycystic ovarian syndrome].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20071001

[Relation of serum uric acid levels with basic metabolic parameters in patients with metabolic syndrome during insulin-sensitizing therapy].

Georgian medical news 20071001

Polycystic ovary syndrome and female reproduction.

British journal of nursing (Mark Allen Publishing) 20071001

Who should benefit from the use of alpha-glucosidase inhibitors?

Current diabetes reports 20071001

[Simultaneous determination of metformin and glipizide in human plasma by liquid chromatography-tandem mass spectrometry].

Yao xue xue bao = Acta pharmaceutica Sinica 20071001

Pattern of potential drug-drug interactions in diabetic out-patients in a tertiary care teaching hospital in Nepal.

The Medical journal of Malaysia 20071001

Managing anovulatory infertility and polycystic ovary syndrome.

BMJ (Clinical research ed.) 20070929

Liquid chromatography tandem mass spectrometry method for simultaneous determination of antidiabetic drugs metformin and glyburide in human plasma.

Journal of pharmaceutical and biomedical analysis 20070921

Metformin, heart failure, and lactic acidosis: is metformin absolutely contraindicated?

BMJ (Clinical research ed.) 20070908

Catalytic action of copper (II) ion on electrochemical oxidation of metformine and voltammetric determination of metformine in pharmaceuticals.

Journal of pharmaceutical and biomedical analysis 20070903

The effects of rosiglitazone, metformin, and diet with exercise in nonalcoholic fatty liver disease.

Digestive diseases and sciences 20070901

Long-term treatment combining continuous subcutaneous insulin infusion with oral hypoglycaemic agents is effective in type 2 diabetes.

Diabetes & metabolism 20070901

Comparison between vildagliptin and metformin to sustain reductions in HbA(1c) over 1 year in drug-naïve patients with Type 2 diabetes.

Diabetic medicine : a journal of the British Diabetic Association 20070901

Increased body iron stores of obese women with polycystic ovary syndrome are a consequence of insulin resistance and hyperinsulinism and are not a result of reduced menstrual losses.

Diabetes care 20070901

Possible role of 5'AMP-activated protein kinase in the metformin-mediated arrest of bovine oocytes at the germinal vesicle stage during in vitro maturation.

Biology of reproduction 20070901

AMP kinase activation increases glucose uptake, decreases apoptosis, and improves pregnancy outcome in embryos exposed to high IGF-I concentrations.

Diabetes 20070901

Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, in patients with type 2 diabetes mellitus inadequately controlled on glimepiride alone or on glimepiride and metformin.

Diabetes, obesity & metabolism 20070901

Clomiphene citrate versus metformin as first-line approach for the treatment of anovulation in infertile patients with polycystic ovary syndrome.

The Journal of clinical endocrinology and metabolism 20070901

Persisting benefits 12-18 months after discontinuation of pubertal metformin therapy in low birthweight girls.

Clinical endocrinology 20070901

Pharmacotherapeutic options for overweight adolescents.

The Annals of pharmacotherapy 20070901

[Pharmacological recommendations in the daily metabolic control of diabetes mellitus type 2. The role of the new insulins].

Revista clinica espanola 20070901

The management of insulin resistance in polycystic ovary syndrome.

Trends in endocrinology and metabolism: TEM 20070901

Liver dysfunction in paediatric obesity: a randomized, controlled trial of metformin.

Acta paediatrica (Oslo, Norway : 1992) 20070901

Drug-induced vitamin B12 deficiency.

The Nurse practitioner 20070901

Rosiglitazone and myocardial infarction: cause for concern or misleading meta-analysis?

Diabetic medicine : a journal of the British Diabetic Association 20070901

Clomiphene versus metformin for ovulation induction in polycystic ovary syndrome: the winner is ...

The Journal of clinical endocrinology and metabolism 20070901

[Alternative approaches to ovarian stimulation].

Gynecologie, obstetrique & fertilite 20070901

The effects of tesaglitazar as add-on treatment to metformin in patients with poorly controlled type 2 diabetes.

Diabetes & vascular disease research 20070901

Hyperhomocysteinemia, deep vein thrombosis and vitamin B12 deficiency in a metformin-treated diabetic patient.

Journal of the Formosan Medical Association = Taiwan yi zhi 20070901

Obesity and the polycystic ovary syndrome.

Minerva endocrinologica 20070901

[The effect of metformin on insulin receptor protein tyrosine kinase activity of HIT-T15 cell exposed to high concentration glucose and free fatty acid].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20070901

[Fat cells becoming ever more prolific--editorial].

Vnitrni lekarstvi 20070901

[Serum level of retinol-binding protein 4 in obese patients with insulin resistance and in patients with type 2 diabetes treated with metformin].

Vnitrni lekarstvi 20070901

Effect of metformin and rosiglitazone in a prepubertal boy with Alström syndrome.

Journal of pediatric endocrinology & metabolism : JPEM 20070901

Metabolic syndrome: are we at risk?

Nepal Medical College journal : NMCJ 20070901

Economic effect of augmentation strategies in patients with type 2 diabetes initiated on sulfonylureas.

Managed care interface 20070901

[Pioglitazone protects the type-2-diabetes patient from myocardial infarction and stroke].

MMW Fortschritte der Medizin 20070802

Continuous glucose monitoring versus self-monitoring of blood glucose in the treatment of gestational diabetes mellitus.

Diabetes research and clinical practice 20070801

Impact of fasting and postprandial glycemia on overall glycemic control in type 2 diabetes Importance of postprandial glycemia to achieve target HbA1c levels.

Diabetes research and clinical practice 20070801

Formulation and development of hydrodynamically balanced system for metformin: in vitro and in vivo evaluation.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20070801

Effects of adenosine monophosphate-activated kinase activators on bovine oocyte nuclear maturation in vitro.

Molecular reproduction and development 20070801

N-acetyl cysteine vs. metformin in treatment of clomiphene citrate-resistant polycystic ovary syndrome: a prospective randomized controlled study.

Fertility and sterility 20070801

Comparison of two doses of metformin (2.5 and 1.5 g/day) for the treatment of polycystic ovary syndrome and their effect on body mass index and waist circumference.

Fertility and sterility 20070801

Effect of initial combination therapy with sitagliptin, a dipeptidyl peptidase-4 inhibitor, and metformin on glycemic control in patients with type 2 diabetes.

Diabetes care 20070801

Metformin suppresses interleukin (IL)-1beta-induced IL-8 production, aromatase activation, and proliferation of endometriotic stromal cells.

The Journal of clinical endocrinology and metabolism 20070801

Insulin sensitivity after metformin suspension in normal-weight women with polycystic ovary syndrome.

The Journal of clinical endocrinology and metabolism 20070801

Pharmacological activators of AMP-activated protein kinase have different effects on Na+ transport processes across human lung epithelial cells.

British journal of pharmacology 20070801

Both slow-release and regular-form metformin improve glycemic control without altering plasma visfatin level in patients with type 2 diabetes mellitus.

Metabolism: clinical and experimental 20070801

Polycystic ovary syndrome update in adolescence.

Current opinion in pediatrics 20070801

Metformin prevents an adaptive increase in GSH and induces apoptosis under the conditions of GSH deficiency in H4IIE cells.

Journal of toxicology and environmental health. Part A 20070801

Loss of glycemic control in patients with type 2 diabetes mellitus who were receiving initial metformin, sulfonylurea, or thiazolidinedione monotherapy.

Pharmacotherapy 20070801

Formulation and optimization of sustained release matrix tablet of metformin HCl 500 mg using response surface methodology.

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20070801

Secondary failure of glycemic control for patients adding thiazolidinedione or sulfonylurea therapy to a metformin regimen.

The American journal of managed care 20070801

Functional involvement of organic cation transporter1 (OCT1/Oct1) in the hepatic uptake of organic cations in humans and rats.

Xenobiotica; the fate of foreign compounds in biological systems 20070801

The incretin mimetic exenatide as a monotherapy in patients with type 2 diabetes.

Diabetes technology & therapeutics 20070801

Effects of pioglitazone in combination with metformin or a sulfonylurea compared to a fixed-dose combination of metformin and glibenclamide in patients with type 2 diabetes.

Diabetes technology & therapeutics 20070801

Effects of early use of pioglitazone in combination with metformin in patients with newly diagnosed type 2 diabetes.

Current medical research and opinion 20070801

Type 2 diabetes: the end of clinical inertia.

Southern medical journal 20070801

Pioglitazone + metformin: new drug. A combination product to avoid.

Prescrire international 20070801

Changing incident diabetes regimens: a Veterans Administration cohort study from 2000 to 2005.

Diabetes care 20070801

Acromegaly symptoms without pituitary adenoma in an adolescent.

Journal of pediatric endocrinology & metabolism : JPEM 20070801

Treatment update: thiazolidinediones in combination with metformin for the treatment of type 2 diabetes.

Vascular health and risk management 20070801

Analysis of metformin dosage formulations by capillary electrophoresis at nano scale detection.

Combinatorial chemistry & high throughput screening 20070801

Metformin reduces thyrotropin levels in obese, diabetic women with primary hypothyroidism on thyroxine replacement therapy.

Endocrine 20070801

Initiating insulin in patients with type 2 diabetes.

The Journal of family practice 20070801

[Metformin-related lactic acidosis in an 85-year-old woman].

Nederlands tijdschrift voor geneeskunde 20070728

[Metformin-related lactic acidosis in an 85-year-old woman].

Nederlands tijdschrift voor geneeskunde 20070728

[Metformin-related lactic acidosis in an 85-year-old woman].

Nederlands tijdschrift voor geneeskunde 20070728

Activation of 5'-AMP-activated kinase with diabetes drug metformin induces casein kinase Iepsilon (CKIepsilon)-dependent degradation of clock protein mPer2.

The Journal of biological chemistry 20070720

Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth.

Cancer research 20070715

Rosiglitazone evaluated for cardiovascular outcomes--an interim analysis.

The New England journal of medicine 20070705

Rosiglitazone and cardiotoxicity--weighing the evidence.

The New England journal of medicine 20070705

Differential effect of pioglitazone (PGZ) and rosiglitazone (RGZ) on postprandial glucose and lipid metabolism in patients with type 2 diabetes mellitus: a prospective, randomized crossover study.

Diabetes/metabolism research and reviews 20070701

Prospective, randomized trial of metformin and vitamins for the reduction of plasma homocysteine in insulin-resistant polycystic ovary syndrome.

Fertility and sterility 20070701

Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration.

American journal of physiology. Heart and circulatory physiology 20070701

Metformin and exercise reduce muscle FAT/CD36 and lipid accumulation and blunt the progression of high-fat diet-induced hyperglycemia.

American journal of physiology. Endocrinology and metabolism 20070701

Comment on: Nauck MA, Duran S, Kim D et al (2007) A comparison of twice-daily exenatide and biphasic insulin aspart in patients with type 2 diabetes who were suboptimally controlled with sulfonylurea and metformin: a non-inferiority study. Diabetologia 50:259-267.

Diabetologia 20070701

A randomized controlled trial examining combinations of repaglinide, metformin and NPH insulin.

Diabetic medicine : a journal of the British Diabetic Association 20070701

Comparison of ethinyl-estradiol plus cyproterone acetate versus metformin effects on classic metabolic cardiovascular risk factors in women with the polycystic ovary syndrome.

The Journal of clinical endocrinology and metabolism 20070701

Impact of oral antihyperglycemic therapy on all-cause mortality among patients with diabetes in the Veterans Health Administration.

Diabetes care 20070701

Differential effect of beta-blocker therapy on insulin resistance as a function of insulin sensitizer use: results from GEMINI.

Diabetic medicine : a journal of the British Diabetic Association 20070701

Simultaneous determination of metformin and rosiglitazone in human plasma by liquid chromatography/tandem mass spectrometry with electrospray ionization: application to a pharmacokinetic study.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070701

Effects of lifestyle changes and metformin on salt sensitivity and nitric oxide metabolism in obese salt-sensitive Hispanics.

Journal of human hypertension 20070701

Metformin as an adjunctive treatment to control body weight and metabolic dysfunction during olanzapine administration: a multicentric, double-blind, placebo-controlled trial.

Schizophrenia research 20070701

Simultaneous assay of metformin and glibenclamide in human plasma based on extraction-less sample preparation procedure and LC/(APCI)MS.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070701

A case of fatal intoxication from metformin.

Journal of forensic sciences 20070701

Oral antidiabetic agents in pregnancy and lactation: a paradigm shift?

The Annals of pharmacotherapy 20070701

The different mechanisms of insulin sensitizers to prevent type 2 diabetes in OLETF rats.

Diabetes/metabolism research and reviews 20070701

Coronary heart disease outcomes in patients receiving antidiabetic agents.

Pharmacoepidemiology and drug safety 20070701

Prevention of contrast-induced nephropathy: a critical review.

Current opinion in nephrology and hypertension 20070701

[Status of glitazones in treatment of type 2 diabetes mellitus].

Der Internist 20070701

Short-term effects of metformin in type 2 diabetes.

Diabetes, obesity & metabolism 20070701

Nateglinide or gliclazide in combination with metformin for treatment of patients with type 2 diabetes mellitus inadequately controlled on maximum doses of metformin alone: 1-year trial results.

Diabetes, obesity & metabolism 20070701

Retinol binding protein 4 expression in humans: relationship to insulin resistance, inflammation, and response to pioglitazone.

The Journal of clinical endocrinology and metabolism 20070701

Pharmacological management of gestational diabetes: an overview.

Diabetes care 20070701

A trial in progress: gestational diabetes. Treatment with metformin compared with insulin (the Metformin in Gestational Diabetes [MiG] trial).

Diabetes care 20070701

Metformin administration improves leukocyte count in women with polycystic ovary syndrome: a 6-month prospective study.

European journal of endocrinology 20070701

Sodium alginate microspheres of metformin HCl: formulation and in vitro evaluation.

Current drug delivery 20070701

Effects of lifestyle intervention and metformin on weight management and markers of metabolic syndrome in obese adolescents.

Journal of the American Academy of Nurse Practitioners 20070701

Preventing diabetes, Part II: an action plan.

Harvard men's health watch 20070701

New medications help those with diabetes avoid heart trouble. Drugs mimic the body's natural insulin and glucose controls, but diet and exercise are still keys to controlling the disease.

Heart advisor 20070701

Pioglitazone and metformin.

Drugs of today (Barcelona, Spain : 1998) 20070701

Effects of bacterial lipopolysaccharide on the pharmacokinetics of metformin in rats.

International journal of pharmaceutics 20070607

Sitagliptin/metformin (Janumet) for type 2 diabetes.

The Medical letter on drugs and therapeutics 20070604

Increase of multiple pregnancies caused by ovulation induction with gonadotropin in combination with metformin in infertile women with polycystic ovary syndrome.

Fertility and sterility 20070601

AMP-activated protein kinase agonists increase mRNA content of the muscle-specific ubiquitin ligases MAFbx and MuRF1 in C2C12 cells.

American journal of physiology. Endocrinology and metabolism 20070601

Simple and rapid method determination for metformin in human plasma using high performance liquid chromatography tandem mass spectrometry: application to pharmacokinetic studies.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070601

Body size and shape changes and the risk of diabetes in the diabetes prevention program.

Diabetes 20070601

A randomized, double-blind, placebo-controlled, multicenter study to assess the efficacy and safety of topiramate controlled release in the treatment of obese type 2 diabetic patients.

Diabetes care 20070601

The effects of metformin and glibenclamide on glucose metabolism, counter-regulatory hormones and cardiovascular responses in women with Type 2 diabetes during exercise of moderate intensity.

Diabetic medicine : a journal of the British Diabetic Association 20070601

Polycystic ovary syndrome: androgens and hypertension.

Hypertension (Dallas, Tex. : 1979) 20070601

A double-blind randomized study comparing the effects of continuing or not continuing rosiglitazone + metformin therapy when starting insulin therapy in people with Type 2 diabetes.

Diabetic medicine : a journal of the British Diabetic Association 20070601

Is metformin the treatment of choice for anovulation in polycystic ovary syndrome?

Nature clinical practice. Endocrinology & metabolism 20070601

Rosiglitazone RECORD study: glucose control outcomes at 18 months.

Diabetic medicine : a journal of the British Diabetic Association 20070601

Metformin and glitazones: do they really help PCOS patients?

The Journal of family practice 20070601

Sleep apnea is induced by a high-fat diet and reversed and prevented by metformin in non-obese rats.

Obesity (Silver Spring, Md.) 20070601

Metformin/rosiglitazone combination pill (Avandamet) for the treatment of patients with Type 2 diabetes.

Expert opinion on pharmacotherapy 20070601

The use of oral antidiabetic agents in primary care.

Australian family physician 20070601

Janumet.

JAAPA : official journal of the American Academy of Physician Assistants 20070601

Comparison of the kinetic characteristics of inhibitory effects exerted by biguanides and H2-blockers on human and rat organic cation transporter-mediated transport: Insight into the development of drug candidates.

Xenobiotica; the fate of foreign compounds in biological systems 20070601

Severe hypoglycemia in a patient with type 2 diabetes mellitus on metformin monotherapy.

The Journal of the Association of Physicians of India 20070601

Effect of chronic co-administration of metformin and vitamin C on plasma glucose and lipid concentrations in normal rats.

African journal of medicine and medical sciences 20070601

[Classic drug in diabetes therapy. Revise contraindications?].

MMW Fortschritte der Medizin 20070531

Release of non-neuronal acetylcholine from the isolated human placenta is affected by antidepressants.

Life sciences 20070530

CCAAT/enhancer-binding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) mice.

The Journal of biological chemistry 20070525

Metformin prevents methylglyoxal-induced apoptosis of mouse Schwann cells.

Biochemical and biophysical research communications 20070525

New treatments for diabetes.

The New England journal of medicine 20070524

[Polycystic ovary syndrome (PCOS)].

MMW Fortschritte der Medizin 20070524

Hospital admission associated with Medicare Part D 'doughnut hole'.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20070515

[Efficacy and safety of extended-release metformin in treatment of type 2 diabetes mellitus].

Zhonghua yi xue za zhi 20070515

Treatment of infertility in the polycystic ovary syndrome.

The New England journal of medicine 20070510

Treatment of infertility in the polycystic ovary syndrome.

The New England journal of medicine 20070510

Anti-diabetic effects of Cichorium intybus in streptozotocin-induced diabetic rats.

Journal of ethnopharmacology 20070504

Metformin prolongs the postprandial fall in plasma ghrelin concentrations in type 2 diabetes.

Diabetes/metabolism research and reviews 20070501

Metabolic syndrome does not increase the risk of conversion of impaired glucose tolerance to diabetes in Asian Indians--Result of Indian diabetes prevention programme.

Diabetes research and clinical practice 20070501

The risk of coronary heart disease in type 2 diabetic patients exposed to thiazolidinediones compared to metformin and sulfonylurea therapy.

Pharmacoepidemiology and drug safety 20070501

Metformin versus oral contraceptive pill in polycystic ovary syndrome: a Cochrane review.

Human reproduction (Oxford, England) 20070501

Combined low-dose pioglitazone, flutamide, and metformin for women with androgen excess.

The Journal of clinical endocrinology and metabolism 20070501

Lowering effect on postprandial glycemic response of nopales added to Mexican breakfasts.

Diabetes care 20070501

Comment on: Evans JMM, Ogston SA, Emslie-Smith A, Morris AD (2006) Risk of mortality and adverse cardiovascular outcomes in type 2 diabetes: a comparison of patients treated with sulfonylureas and metformin. Diabetologia 49:930-936.

Diabetologia 20070501

Introducing estimated glomerular filtration rate (eGFR) into clinical practice in the UK: implications for the use of metformin.

Diabetic medicine : a journal of the British Diabetic Association 20070501

Diabetes care for patients with peripheral arterial disease.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 20070501

Short-term effects of metformin in type 2 diabetes.

Diabetes, obesity & metabolism 20070501

Weight gain in type 2 diabetes mellitus.

Diabetes, obesity & metabolism 20070501

Targeting hyperglycaemia with either metformin or repaglinide in non-obese patients with type 2 diabetes: results from a randomized crossover trial.

Diabetes, obesity & metabolism 20070501

Metformin and fetal malformations.

Fertility and sterility 20070501

Dual antiglioma action of metformin: cell cycle arrest and mitochondria-dependent apoptosis.

Cellular and molecular life sciences : CMLS 20070501

Pharmacogenetics of metformin response: a step in the path toward personalized medicine.

The Journal of clinical investigation 20070501

Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action.

The Journal of clinical investigation 20070501

Controlled natural cycle IVF: a novel approach for a dominant follicle during an in-vitro maturation cycle.

Reproductive biomedicine online 20070501

Do we need new drugs for the treatment of type 2 diabetes mellitus?

The Netherlands journal of medicine 20070501

What is the best first-step therapeutic approach in treating anovulatory infertility in patients with polycystic ovary syndrome? Questions that are still unanswered.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20070501

Metformin in normal-weight hirsute women with polycystic ovary syndrome with normal insulin sensitivity.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20070501

Blood pressure control and inflammatory markers in type 2 diabetic patients treated with pioglitazone or rosiglitazone and metformin.

Hypertension research : official journal of the Japanese Society of Hypertension 20070501

[Effect of lifestyle adjustment, metformin and rosiglitazone in polycystic ovary syndrome].

Zhonghua fu chan ke za zhi 20070501

Treatment of type 2 diabetes mellitus and the incretin system.

South Dakota medicine : the journal of the South Dakota State Medical Association 20070501

Comparison of extended-release metformin in combination with a sulfonylurea (glyburide) to sulfonylurea monotherapy in adult patients with type 2 diabetes: a multicenter, double-blind, randomized, controlled, phase III study.

Clinical therapeutics 20070501

Induction of long-term glycemic control in type 2 diabetic patients using pioglitazone and metformin combination.

The Journal of the Association of Physicians of India 20070501

[Metformin-related lactic acidosis in an 85-year-old woman].

Nederlands tijdschrift voor geneeskunde 20070428

[Fatal autointoxication with metformin].

Nederlands tijdschrift voor geneeskunde 20070428

Meglitinide analogues for type 2 diabetes mellitus.

The Cochrane database of systematic reviews 20070418

[Diabetes type 2 in pediatrics: diagnosis and management].

Revue medicale suisse 20070418

[ADOPT study: Reevaluation of antidiabetic drugs. Control of diabetes].

MMW Fortschritte der Medizin 20070412

[Consulting Prof. Dr. Stephan Matthaei. Quakenbrück diabetes center. Prescription relevant conclusions].

MMW Fortschritte der Medizin 20070412

The long and short of metformin-related vitamin B12 deficiency.

Archives of internal medicine 20070409

Vitamin B12 deficiency in patients receiving metformin: clinical data.

Archives of internal medicine 20070409

Metformin and vitamin B12 deficiency: association and not causation may play a major role in cohort studies.

Archives of internal medicine 20070409

Effect of Sclerocarya birrea (Anacardiaceae) stem bark methylene chloride/methanol extract on streptozotocin-diabetic rats.

Journal of ethnopharmacology 20070404

Summaries for patients. Exenatide therapy for type 2 diabetes.

Annals of internal medicine 20070403

The effect of adding exenatide to a thiazolidinedione in suboptimally controlled type 2 diabetes: a randomized trial.

Annals of internal medicine 20070403

Exenatide in combination therapy: small study, big market, and many unanswered questions.

Annals of internal medicine 20070403

An open-label pilot study of the combination therapy of metformin and fluoxetine for weight reduction.

International journal of obesity (2005) 20070401

Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone.

The Journal of clinical endocrinology and metabolism 20070401

Acute effects of metformin therapy include improvement of insulin resistance and ovarian morphology.

Fertility and sterility 20070401

Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin.

Diabetes care 20070401

Insulin glargine in combination with nateglinide in people with Type 2 diabetes: a randomized placebo-controlled trial.

Diabetic medicine : a journal of the British Diabetic Association 20070401

Clinical characteristics influencing the effectiveness of metformin on Japanese type 2 diabetes receiving sulfonylureas.

Endocrine journal 20070401

Metformin treatment in pregnant women with polycystic ovary syndrome--is reduced complication rate mediated by changes in the uteroplacental circulation?

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 20070401

Initial monotherapy with either metformin or sulphonylureas often fails to achieve or maintain current glycaemic goals in patients with Type 2 diabetes in UK primary care.

Diabetic medicine : a journal of the British Diabetic Association 20070401

Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer.

British journal of pharmacology 20070401

Metformin therapy in girls with polycystic ovary syndrome: a self-controlled clinical trial.

Archives of Iranian medicine 20070401

The safety of metformin in heart failure.

The Annals of pharmacotherapy 20070401

Glimepiride versus metformin as monotherapy in pediatric patients with type 2 diabetes: a randomized, single-blind comparative study.

Diabetes care 20070401

Factors associated with diabetes onset during metformin versus placebo therapy in the diabetes prevention program.

Diabetes 20070401

The effects of metformin and rosiglitazone, alone and in combination, on the ovary and endometrium in polycystic ovary syndrome.

American journal of obstetrics and gynecology 20070401

FPIN's clinical inquiries. Glycemic control in patients with type 2 diabetes.

American family physician 20070401

Larval zebrafish as a model for glucose metabolism: expression of phosphoenolpyruvate carboxykinase as a marker for exposure to anti-diabetic compounds.

Journal of molecular endocrinology 20070401

Treatment options for type 2 diabetes in adolescents and youth: a study of the comparative efficacy of metformin alone or in combination with rosiglitazone or lifestyle intervention in adolescents with type 2 diabetes.

Pediatric diabetes 20070401

Metformin: new indication. Useful for some children with type 2 diabetes.

Prescrire international 20070401

Effects of metformin treatment in women with polycystic ovary syndrome depends on insulin resistance.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20070401

Canadian Association of Radiologists: consensus guidelines for the prevention of contrast-induced nephropathy.

Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes 20070401

Effect of metformin therapy on plasma adiponectin and leptin levels in obese and insulin resistant postmenopausal females with type 2 diabetes.

Georgian medical news 20070401

[Clinical effects of metformin in patients with polcystic ovarian syndrome].

Ginecologia y obstetricia de Mexico 20070401

Metformin and polycystic ovary syndrome.

Current opinion in endocrinology, diabetes, and obesity 20070401

Glycemic durability of monotherapy for diabetes.

The New England journal of medicine 20070329

Glycemic durability of monotherapy for diabetes.

The New England journal of medicine 20070329

[Exenatide--an incretin-mimetic agent for the treatment of type 2 diabetes mellitus].

Deutsche medizinische Wochenschrift (1946) 20070316

[Metformin and vitamin B 12 deficiency].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20070315

An investigation into keratinolytic enzymes to enhance ungual drug delivery.

International journal of pharmaceutics 20070306

Insulin levels, insulin resistance and the use of metformin in polycystic ovary syndrome.

The Medical journal of Australia 20070305

Role of metformin in the initiation of pharmacotherapy for type 2 diabetes: an Asian-Pacific perspective.

Diabetes research and clinical practice 20070301

Improvement in coronary vascular dysfunction produced with euglycaemic control in patients with type 2 diabetes.

Heart (British Cardiac Society) 20070301

Effects of insulin therapy on liver fat content and hepatic insulin sensitivity in patients with type 2 diabetes.

American journal of physiology. Endocrinology and metabolism 20070301

Effects of metformin on bovine granulosa cells steroidogenesis: possible involvement of adenosine 5' monophosphate-activated protein kinase (AMPK).

Biology of reproduction 20070301

Metformin improves skin capillary reactivity in normoglycaemic subjects with the metabolic syndrome.

Diabetic medicine : a journal of the British Diabetic Association 20070301

Metformin reduces endothelial cell expression of both the receptor for advanced glycation end products and lectin-like oxidized receptor 1.

Metabolism: clinical and experimental 20070301

Insulin counter-regulatory factors, fibrinogen and C-reactive protein during olanzapine administration: effects of the antidiabetic metformin.

International clinical psychopharmacology 20070301

Effect of adding sitagliptin, a dipeptidyl peptidase-4 inhibitor, to metformin on 24-h glycaemic control and beta-cell function in patients with type 2 diabetes.

Diabetes, obesity & metabolism 20070301

Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: a randomized, double-blind, non-inferiority trial.

Diabetes, obesity & metabolism 20070301

Pharmacologic therapy of polycystic ovary syndrome.

Clinical obstetrics and gynecology 20070301

Ovulation induction management of PCOS.

Clinical obstetrics and gynecology 20070301

Pregnancy considerations in women with polycystic ovary syndrome.

Clinical obstetrics and gynecology 20070301

A randomized trial of the effects of rosiglitazone and metformin on inflammation and subclinical atherosclerosis in patients with type 2 diabetes.

American heart journal 20070301

Effects of medical therapy on insulin resistance and the cardiovascular system in polycystic ovary syndrome.

Diabetes care 20070301

An anti-aging drug today: from senescence-promoting genes to anti-aging pill.

Drug discovery today 20070301

Treatment of fibrosis in nonalcoholic fatty liver disease.

Current gastroenterology reports 20070301

Race, ethnicity, and use of thiazolidinediones among US adults with diabetes.

Current medical research and opinion 20070301

Insulin as initial therapy in type 2 diabetes: effective, safe, and well accepted.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20070301

Metformin before and during pregnancy and lactation in polycystic ovary syndrome.

Expert opinion on drug safety 20070301

[Detection of LADA-type diabetes in overweight diabetic patients. Is treatment with metformin suitable?].

Atencion primaria 20070301

Metformin administration is more effective when non-obese patients with polycystic ovary syndrome show both hyperandrogenism and hyperinsulinemia.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20070301

[Vascular dysfunction in metabolic disorders: evaluation of some therapeutic interventions].

Bulletin de l'Academie nationale de medecine 20070301

AMP-activated protein kinase in metabolic control and insulin signaling.

Circulation research 20070216

Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.

The New England journal of medicine 20070208

Treating the polycystic ovary syndrome the old-fashioned way.

The New England journal of medicine 20070208

Succinic acid monoethyl ester, a novel insulinotropic agent: effect on lipid composition and lipid peroxidation in streptozotocin-nicotin-amide induced type 2 diabetic rats.

Molecular and cellular biochemistry 20070201

A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy.

American journal of physiology. Renal physiology 20070201

Polycystic ovary-related miscarriage: should metformin be proposed to such frustrated women?

Human reproduction (Oxford, England) 20070201

Human visfatin expression: relationship to insulin sensitivity, intramyocellular lipids, and inflammation.

The Journal of clinical endocrinology and metabolism 20070201

Metformin inhibits adenosine 5'-monophosphate-activated kinase activation and prevents increases in neuropeptide Y expression in cultured hypothalamic neurons.

Endocrinology 20070201

Effects of chronic rosiglitazone therapy on gene expression in human adipose tissue in vivo in patients with type 2 diabetes.

The Journal of clinical endocrinology and metabolism 20070201

A comparison of twice-daily exenatide and biphasic insulin aspart in patients with type 2 diabetes who were suboptimally controlled with sulfonylurea and metformin: a non-inferiority study.

Diabetologia 20070201

Simultaneous determination of metformin and glipizide in human plasma by liquid chromatography-tandem mass spectrometry.

Biomedical chromatography : BMC 20070201

Effects of rosiglitazone and metformin on inflammatory markers and adipokines: decrease in interleukin-18 is an independent factor for the improvement of homeostasis model assessment-beta in type 2 diabetes mellitus.

Clinical endocrinology 20070201

Metabolic effects of pioglitazone and rosiglitazone in patients with diabetes and metabolic syndrome treated with metformin.

Internal medicine journal 20070201

Severe lactic acidosis and rhabdomyolysis following metformin and ramipril overdose.

British journal of anaesthesia 20070201

Twelve weeks' treatment with diazoxide without insulin supplementation in Type 2 diabetes is feasible but does not improve insulin secretion.

Diabetic medicine : a journal of the British Diabetic Association 20070201

Antidiabetic agents in subjects with mild dysglycaemia: prevention or early treatment of type 2 diabetes?

Diabetes & metabolism 20070201

[Drug treatment of type 2 diabetes].

Presse medicale (Paris, France : 1983) 20070201

Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the Diabetes Prevention Program.

Diabetes 20070201

Is metformin safe in patients with mild renal insufficiency?

Diabetes care 20070201

An open, randomized, parallel-group study to compare the efficacy and safety profile of inhaled human insulin (Exubera) with glibenclamide as adjunctive therapy in patients with type 2 diabetes poorly controlled on metformin: response to Barnett et al.

Diabetes care 20070201

Don't throw the baby out with the bath water: mortality with combination metformin and sulfonylurea.

Diabetes/metabolism research and reviews 20070201

Are the beneficial cardiovascular effects of simvastatin and metformin also associated with a hormone-dependent mechanism improving insulin sensitivity?

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20070201

Combination of oral antidiabetic agents with basal insulin versus premixed insulin alone in randomized elderly patients with type 2 diabetes mellitus.

Journal of the American Geriatrics Society 20070201

Metformin: preventable lactic acidosis.

Prescrire international 20070201

Formulation and evaluation of ethyl cellulose microspheres prepared by the multiple emulsion technique.

Die Pharmazie 20070201

Design and in vitro testing of a floatable gastroretentive tablet of metformin hydrochloride.

Die Pharmazie 20070201

Sitagliptin.

Nature reviews. Drug discovery 20070201

Antidiabetic prescriptions and glycemic control in German patients with type 2 diabetes mellitus: a retrospective database study.

Clinical therapeutics 20070201

C-reactive protein in obese PCOS women and the effect of metformin therapy.

Bosnian journal of basic medical sciences 20070201

Drugs improving insulin resistance for non-alcoholic fatty liver disease and/or non-alcoholic steatohepatitis.

The Cochrane database of systematic reviews 20070124

Insulin-sensitising drugs versus the combined oral contraceptive pill for hirsutism, acne and risk of diabetes, cardiovascular disease, and endometrial cancer in polycystic ovary syndrome.

The Cochrane database of systematic reviews 20070124

Metformin therapy in a transgenic mouse model of Huntington's disease.

Neuroscience letters 20070110

[Metformin can cause vitamin B 12 deficiency in diabetes].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20070104

Anti-diabetic effects of Sutherlandia frutescens in Wistar rats fed a diabetogenic diet.

Journal of ethnopharmacology 20070103

Effects of metformin and rosiglitazone in HIV-infected patients with hyperinsulinemia and elevated waist/hip ratio.

AIDS (London, England) 20070102

Efficacy and safety of topiramate in combination with metformin in the treatment of obese subjects with type 2 diabetes: a randomized, double-blind, placebo-controlled study.

International journal of obesity (2005) 20070101

Prevalence of the metabolic syndrome in Zhejiang Chinese obese children and adolescents and the effect of metformin combined with lifestyle intervention.

International journal of obesity (2005) 20070101

Effects of pioglitazone and metformin on beta-cell function in nondiabetic subjects at high risk for type 2 diabetes.

American journal of physiology. Endocrinology and metabolism 20070101

Phentermine, sibutramine and metformin could be used for the prevention and treatment of steroid-induced weight gain.

Medical hypotheses 20070101

Comparison of clomiphene citrate, metformin, or the combination of both for first-line ovulation induction and achievement of pregnancy in 154 women with polycystic ovary syndrome.

Fertility and sterility 20070101

Human organic cation transporter (OCT1 and OCT2) gene polymorphisms and therapeutic effects of metformin.

Journal of human genetics 20070101

Effect of metformin administration on plasma advanced glycation end product levels in women with polycystic ovary syndrome.

Metabolism: clinical and experimental 20070101

The perioperative management of metformin for the oral and maxillofacial surgery patient: risks and recommendations.

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20070101

Thinking like a pancreas: perioperative glycemic control.

Anesthesia and analgesia 20070101

Recent metformin ingestion does not increase in-hospital morbidity or mortality after cardiac surgery.

Anesthesia and analgesia 20070101

A lifetime modelled economic evaluation comparing pioglitazone and rosiglitazone for the treatment of type 2 diabetes mellitus in the UK.

PharmacoEconomics 20070101

Oral antidiabetic drugs: bioavailability assessment of fixed-dose combination tablets of pioglitazone and metformin. Effect of body weight, gender, and race on systemic exposures of each drug.

Journal of clinical pharmacology 20070101

Oral antidiabetic drugs: effect of food on absorption of pioglitazone and metformin from a fixed-dose combination tablet.

Journal of clinical pharmacology 20070101

Weight changes following the initiation of new anti-hyperglycaemic therapies.

Diabetes, obesity & metabolism 20070101

The addition of metformin in type 1 diabetes improves insulin sensitivity, diabetic control, body composition and patient well-being.

Diabetes, obesity & metabolism 20070101

[Severe lactic acidosis associated to metformin intoxication].

Nutricion hospitalaria 20070101

Metformin and vitamin B12 deficiency: the role of H2 receptor antagonists and proton pump inhibitors.

Age and ageing 20070101

The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial.

Journal of alternative and complementary medicine (New York, N.Y.) 20070101

Metformin restores the penile expression of nitric oxide synthase in high-fat-fed obese rats.

Journal of andrology 20070101

Regulation of the atherogenic properties of vascular smooth muscle proteoglycans by oral anti-hyperglycemic agents.

Journal of diabetes and its complications 20070101

Effects of metformin or rosiglitazone on serum concentrations of homocysteine, folate, and vitamin B12 in patients with type 2 diabetes mellitus.

Journal of diabetes and its complications 20070101

An optimized in vitro assay for screening compounds that stimulate liver cell glucose utilization with low cytotoxicity.

Journal of pharmacological and toxicological methods 20070101

A comparative study of the effects of hypoglycemic agents on serum electrolytes in the diabetic patients.

Pakistan journal of pharmaceutical sciences 20070101

[ADOPT study: which first-line glucose-lowering oral medication in type 2 diabetes?].

Revue medicale de Liege 20070101

Metformin-associated lactic acidosis in a burn patient.

Journal of burn care & research : official publication of the American Burn Association 20070101

Homocysteine levels are unaffected by metformin treatment in both nonpregnant and pregnant women with polycystic ovary syndrome.

Acta obstetricia et gynecologica Scandinavica 20070101

Metabolic effects of two years of exenatide treatment on diabetes, obesity, and hepatic biomarkers in patients with type 2 diabetes: an interim analysis of data from the open-label, uncontrolled extension of three double-blind, placebo-controlled trials.

Clinical therapeutics 20070101

Hypoglycaemic and hypotensive effects of Globimetula cupulata (DC) Van Tieghem (Loranthaceae) aqueous leaf extract in rats.

Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners 20070101

Metformin plus low-dose glimeperide significantly improves Homeostasis Model Assessment for insulin resistance (HOMA(IR)) and beta-cell function (HOMA(beta-cell)) without hyperinsulinemia in patients with type 2 diabetes mellitus.

American journal of therapeutics 20070101

Exenatide: a review of its use in patients with type 2 diabetes mellitus (as an adjunct to metformin and/or a sulfonylurea).

Drugs 20070101

[Metformin-induced acute lactic acidosis].

Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20070101

Increased prothrombin time and lactic acidosis: rofecoxib drug interaction with acenocoumarin and metformin.

Annals of cardiac anaesthesia 20070101

Comparison of the effects of pioglitazone and metformin on insulin resistance and hormonal markers in patients with impaired glucose tolerance and early diabetes.

Hypertension research : official journal of the Japanese Society of Hypertension 20070101

Thiazolidinedione induced thyroid associated orbitopathy.

BMC ophthalmology 20070101

Relative bioavailability and bioequivalence of metforphin hydrochloride extended-released and immediate-released tablets in healthy Chinese volunteers.

European journal of drug metabolism and pharmacokinetics 20070101

Progress in the treatment of diabetes type 1 and 2.

Pediatric endocrinology, diabetes, and metabolism 20070101

Effect of insulin-metformin combination on hepatic steatosis in patients with type 2 diabetes.

Journal of diabetes and its complications 20070101

Comparison of the effects of zinc alone and zinc associated with selenium and vitamin E on insulin sensitivity and oxidative stress in high-fructose-fed rats.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 20070101

[Medical treatment of type 2 diabetes. Recommendations for good practice].

Diabetes & metabolism 20070101

Bioequivalence study of two metformin formulations.

Arzneimittel-Forschung 20070101

Effects of simvastatin and metformin on inflammation and insulin resistance in individuals with mild metabolic syndrome.

American journal of cardiovascular drugs : drugs, devices, and other interventions 20070101

[ADOPT study. Glitazone controls diabetes progression].

MMW Fortschritte der Medizin 20070101

[New class of oral antidiabetic drugs. Effective in combination with metformin].

MMW Fortschritte der Medizin 20070101

Ovulation disorders: Part II. Anovulation associated with normal estrogen.

Clinical and experimental obstetrics & gynecology 20070101

Management of type 2 diabetes mellitus associated with pituitary gigantism.

Pituitary 20070101

[New rank order of antidiabetic drugs. Using glitazone before sulfonylurea drugs? (interview by Dr. Dirk Einecke)].

MMW Fortschritte der Medizin 20070101

Metformin-associated lactic acidosis precipitated by diarrhea.

American journal of therapeutics 20070101

Changes in glucose tolerance with metformin treatment in polycystic ovary syndrome: a retrospective analysis.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20070101

Nutritional approach to metabolic changes arising out of schizophrenia therapy: case report.

Internal medicine (Tokyo, Japan) 20070101

Cardiovascular benefits and safety profile of acarbose therapy in prediabetes and established type 2 diabetes.

Cardiovascular diabetology 20070101

Sitagliptin: a novel drug for the treatment of type 2 diabetes.

Cardiology in review 20070101

Does metformin prevent short-term oxidant-induced dna damage? In vitro study on lymphocytes from aged subjects.

Journal of basic and clinical physiology and pharmacology 20070101

[Insulin resistance in type 2 diabetes patients].

Przeglad lekarski 20070101

[No influence of imatinib on type 2 diabetes].

Przeglad lekarski 20070101

[Metformin-associated lactic acidosis and acute renal failure secondary to cardiac catheterism].

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20070101

The role of metformin in polycystic ovary syndrome: a systematic review.

Human reproduction update 20070101

Recognition of fasting or overall hyperglycaemia when starting insulin treatment in patients with type 2 diabetes in general practice.

Scandinavian journal of primary health care 20070101

[Pathogenetic treatment of non-alcoholic steatohepatitis: arguments, efficacy, safety].

Terapevticheskii arkhiv 20070101

[The effect of metformin on fasting and postprandial insulin secretion in obese patients with diabetes mellitus type 2].

Srpski arhiv za celokupno lekarstvo 20070101

Unmet needs in controlling metabolic disease.

Reviews in cardiovascular medicine 20070101

[Angioedema associated with enalapril].

Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20070101

Focus on metformin - a major cardiovascular medication. 'Diabesity - the biggest epidemic in human history'.

Cardiovascular journal of Africa 20070101

Metformin is effective in achieving biochemical response in patients with nonalcoholic fatty liver disease (NAFLD) not responding to lifestyle interventions.

Annals of hepatology 20070101

Effects of nateglinide and glibenclamide on prothrombotic factors in naïve type 2 diabetic patients treated with metformin: a 1-year, double-blind, randomized clinical trial.

Internal medicine (Tokyo, Japan) 20070101

Rosiglitazone : a review of its use in type 2 diabetes mellitus.

Drugs 20070101

[Metabolic and hemodynamic effects of combined treatment with metformine and rosiglitasone (avandium) in patients with diabetes mellitus type 2 and high cardiovascular risk].

Terapevticheskii arkhiv 20070101

Metabolic effects of rosiglitazone and metformin in Greek patients with recently diagnosed type 2 diabetes.

In vivo (Athens, Greece) 20070101

Metformin.

Endocrine research 20070101

Oral metformin-ascorbic acid co-administration ameliorates alcohol-induced hepatotoxicity in rats.

Nigerian quarterly journal of hospital medicine 20070101

Identification and treatment of prediabetes to prevent progression to type 2 diabetes.

Clinical cornerstone 20070101

Is exenatide improving the treatment of type 2 diabetes? Analysis of the individual clinical trials with exenatide.

Reviews on recent clinical trials 20070101

[Metformin and type 2 diabetes: the UKPDS experience].

Journees annuelles de diabetologie de l'Hotel-Dieu 20070101

[Metformin, fifty years since the arrival of this molecule!].

Journees annuelles de diabetologie de l'Hotel-Dieu 20070101

Metformin as first choice in oral diabetes treatment: the UKPDS experience.

Journees annuelles de diabetologie de l'Hotel-Dieu 20070101

Oral hypoglycemic agents and heart.

Indian heart journal 20070101

Insulin sensitizers in treatment of nonalcoholic fatty liver disease: Systematic review.

World journal of gastroenterology 20061228

[Biguanides].

Nihon rinsho. Japanese journal of clinical medicine 20061228

[Change in ghrelin level with the amelioration of glucose and lipid metabolic disorder in OLETF rats].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20061218

Glucose utilization is suppressed in the gut of insulin-resistant high fat-fed rats and is restored by metformin.

Biochemical pharmacology 20061215

Metformin does not prevent DNA damage in lymphocytes despite its antioxidant properties against cumene hydroperoxide-induced oxidative stress.

Mutation research 20061210

[Metformine hydrochloride reduces both acanthosis nigricans and insulin resistance in Japanese young female].

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20061210

Management of hyperglycaemia in type 2 diabetes: the end of recurrent failure?

BMJ (Clinical research ed.) 20061209

Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy.

The New England journal of medicine 20061207

Thiazolidinediones for initial treatment of type 2 diabetes?

The New England journal of medicine 20061207

Metformin increases the PGC-1alpha protein and oxidative enzyme activities possibly via AMPK phosphorylation in skeletal muscle in vivo.

Journal of applied physiology (Bethesda, Md. : 1985) 20061201

Stimulation of AMP-activated protein kinase is essential for the induction of drug metabolizing enzymes by phenobarbital in human and mouse liver.

Molecular pharmacology 20061201

Contemporary medical therapy for polycystic ovary syndrome.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20061201

Effects of metformin and clomiphene citrate on ovarian vascularity in patients with polycystic ovary syndrome.

Fertility and sterility 20061201

Determination of metformin based on amplification of its voltammetric response by a combination of molecular wire and carbon nanotubes.

Analytical and bioanalytical chemistry 20061201

A Diabetes Outcome Progression Trial (ADOPT): baseline characteristics of Type 2 diabetic patients in North America and Europe.

Diabetic medicine : a journal of the British Diabetic Association 20061201

Effects of pioglitazone and metformin on plasma adiponectin in newly detected type 2 diabetes mellitus.

Clinical endocrinology 20061201

Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone.

Diabetes care 20061201

[Development of body weight during antidiabetic treatment].

Deutsche medizinische Wochenschrift (1946) 20061201

[Oral antidiabetic therapy].

Deutsche medizinische Wochenschrift (1946) 20061201

Sustainability of 8% weight loss, reduction of insulin resistance, and amelioration of atherogenic-metabolic risk factors over 4 years by metformin-diet in women with polycystic ovary syndrome.

Metabolism: clinical and experimental 20061201

Gaining: pediatric patients and use of atypical antipsychotics.

The American journal of psychiatry 20061201

A randomized, double-blind, placebo-controlled trial of metformin treatment of weight gain associated with initiation of atypical antipsychotic therapy in children and adolescents.

The American journal of psychiatry 20061201

Metformin reduces abortion in pregnant women with polycystic ovary syndrome.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20061201

Mathematical modeling shows exenatide improved beta-cell function in patients with type 2 diabetes treated with metformin or metformin and a sulfonylurea.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20061201

What can the clinician do to improve implantation?

Reproductive biomedicine online 20061201

Tolerability and effectiveness of fluoxetine, metformin and sibutramine in reducing anthropometric and metabolic parameters in obese patients.

Arquivos brasileiros de endocrinologia e metabologia 20061201

Metformin: 50 years old, fit as a fiddle, and indispensable for its pivotal role in type 2 diabetes management.

Diabetes & metabolism 20061201

A proof of concept, preliminary study to determine the effect of Yogasnas in controlling type 2 diabetes mellitus in newly detected subjects (when compared to metformin monotherapy).

The Journal of the Association of Physicians of India 20061201

Endogenous insulin signaling protects cultured neurons from oxygen-glucose deprivation-induced cell death.

Neuroscience 20061117

[Human insulin vs. analogs. What is the cost of supplementary insulin therapy?].

MMW Fortschritte der Medizin 20061109

Tissue-specific expression and regulation of GSK-3 in human skeletal muscle and adipose tissue.

American journal of physiology. Endocrinology and metabolism 20061101

Comment on: Evans JM, Ogston SA, Emslie-Smith A, Morris A (2006) risk of mortality and adverse cardiovascular outcomes in type 2 diabetes: a comparison of patients treated with sulfonylureas and metformin. Diabetologia 49:930-936.

Diabetologia 20061101

Determination of antihyperglycemic biguanides in serum and urine using an ion-pair solid-phase extraction technique followed by HPLC-UV on a pentafluorophenylpropyl column and on an octadecyl column.

Biomedical chromatography : BMC 20061101

Metformin and early pregnancy?

Fertility and sterility 20061101

Dose-independent pharmacokinetics of metformin in rats: Hepatic and gastrointestinal first-pass effects.

Journal of pharmaceutical sciences 20061101

Comment on: Evans JMM, Ogston SA, Emslie-Smith A, Morris AD (2006) risk of mortality and adverse cardiovascular outcomes in type 2 diabetes: a comparison of patients treated with sulfonylureas and metformin. Diabetologia 49:930-936.

Diabetologia 20061101

Is the addition of metformin efficacious in the treatment of clomiphene citrate-resistant patients with polycystic ovary syndrome? A structured literature review.

Fertility and sterility 20061101

Improvement in glycaemic control with rosiglitazone/metformin fixed-dose combination therapy in patients with type 2 diabetes with very poor glycaemic control.

Diabetes, obesity & metabolism 20061101

Initial treatment with rosiglitazone/metformin fixed-dose combination therapy compared with monotherapy with either rosiglitazone or metformin in patients with uncontrolled type 2 diabetes.

Diabetes, obesity & metabolism 20061101

Weight gain and insulin requirement in type 2 diabetic patients during the first year after initiating insulin therapy dependent on baseline BMI.

Diabetes, obesity & metabolism 20061101

Use of insulin sensitizing agents in the treatment of polycystic ovary syndrome.

Fertility and sterility 20061101

Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells.

Cancer research 20061101

The CC genotype of the GNAS T393C polymorphism is associated with obesity and insulin resistance in women with polycystic ovary syndrome.

European journal of endocrinology 20061101

Long-term efficacy of metformin therapy in nonobese individuals with type 2 diabetes.

Diabetes care 20061101

Comparison of glargine insulin versus rosiglitazone addition in poorly controlled type 2 diabetic patients on metformin plus sulfonylurea.

Diabetes care 20061101

[Prevention and treatment for development and progression of diabetic macroangiopathy with pioglitazone and metformin].

Nihon rinsho. Japanese journal of clinical medicine 20061101

Clinical inquiries. What is the role of combination therapy (insulin plus oral medication) in type 2 diabetes?

The Journal of family practice 20061101

Generation of reactive oxygen species by endothelial and smooth muscle cells: influence of hyperglycemia and metformin.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20061101

[Acute pancreatitis, acute kidney failure, metformin intoxication and villous rectal adenoma].

Medicina intensiva 20061101

Relationship of body size and shape to the development of diabetes in the diabetes prevention program.

Obesity (Silver Spring, Md.) 20061101

Metformin and antihypertensive therapy with drugs blocking the renin angiotensin system, a cause of concern?

Clinical nephrology 20061101

Changes in weight, papilledema, headache, visual field, and life status in response to diet and metformin in women with idiopathic intracranial hypertension with and without concurrent polycystic ovary syndrome or hyperinsulinemia.

Translational research : the journal of laboratory and clinical medicine 20061101

Is metformin a primary ovulatory agent in patients with polycystic ovary syndrome?

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20061101

Metformin: now or later?

Harvard health letter 20061101

Prevention of diabetes: lifestyle and metformin are the way forward.

BMJ (Clinical research ed.) 20061028

[The practice guideline 'Diabetes mellitus type 2' (second revision) from the Dutch College of General Practitioners; a response from the perspective of general practice].

Nederlands tijdschrift voor geneeskunde 20061021

[The practice guideline 'Diabetes mellitus type 2' (second revision) from the Dutch College of General Practitioners; a response from the perspective of general practice].

Nederlands tijdschrift voor geneeskunde 20061021

Solid phase extraction--non-aqueous capillary electrophoresis for determination of metformin, phenformin and glyburide in human plasma.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061020

Alpha-glucosidase inhibitors for people with impaired glucose tolerance or impaired fasting blood glucose.

The Cochrane database of systematic reviews 20061018

Case records of the Massachusetts General Hospital. Case 31-2006. A 15-year-old girl with severe obesity.

The New England journal of medicine 20061012

Inhibition of dipeptidyl peptidase-IV activity by metformin enhances the antidiabetic effects of glucagon-like peptide-1.

European journal of pharmacology 20061010

Risk factors of vitamin B(12) deficiency in patients receiving metformin.

Archives of internal medicine 20061009

Polycystic ovarian syndrome--prognosis and outcomes.

Best practice & research. Clinical obstetrics & gynaecology 20061001

Preparation and in vitro/in vivo evaluation of sustained-release metformin hydrochloride pellets.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20061001

Transfer of metformin across the dually perfused human placental lobule.

American journal of obstetrics and gynecology 20061001

Treatment with flutamide, metformin, and their combination added to a hypocaloric diet in overweight-obese women with polycystic ovary syndrome: a randomized, 12-month, placebo-controlled study.

The Journal of clinical endocrinology and metabolism 20061001

Effects of enzyme inducers and inhibitors on the pharmacokinetics of metformin in rats: involvement of CYP2C11, 2D1 and 3A1/2 for the metabolism of metformin.

British journal of pharmacology 20061001

Incretin mimetics as a novel therapeutic option for hepatic steatosis.

Liver international : official journal of the International Association for the Study of the Liver 20061001

Rosiglitazone reduces microalbuminuria and blood pressure independently of glycemia in type 2 diabetes patients with microalbuminuria.

Journal of hypertension 20061001

The Pregnancy in Polycystic Ovary Syndrome study: baseline characteristics of the randomized cohort including racial effects.

Fertility and sterility 20061001

Effect of metformin plus roziglitazone compared with metformin alone on glycaemic control in well-controlled Type 2 diabetes.

Diabetic medicine : a journal of the British Diabetic Association 20061001

The effect of metformin on blood glucose control in overweight patients with Type 1 diabetes.

Diabetic medicine : a journal of the British Diabetic Association 20061001

Ovarian stockpiling in polycystic ovary syndrome, infertility, and the combined use of rosiglitazone and metformin.

Diabetes care 20061001

Triple therapy in type 2 diabetes: insulin glargine or rosiglitazone added to combination therapy of sulfonylurea plus metformin in insulin-naïve patients: response to Rosenstock et al.

Diabetes care 20061001

An open, randomized, parallel-group study to compare the efficacy and safety profile of inhaled human insulin (Exubera) with meformin as adjunctive therapy in patients with type 2 diabetes poorly controlled on a sulfonylurea: response to Barnett et al.

Diabetes care 20061001

[Metformin-associated lactic acidosis].

Annales francaises d'anesthesie et de reanimation 20061001

Effects of melatonin and zinc on glycemic control in type 2 diabetic patients poorly controlled with metformin.

Saudi medical journal 20061001

Tolerability and pharmacokinetics of metformin and the dipeptidyl peptidase-4 inhibitor sitagliptin when co-administered in patients with type 2 diabetes.

Current medical research and opinion 20061001

Comparison of metformin versus rosiglitazone in patients with Acanthosis nigricans: a pilot study.

Journal of drugs in dermatology : JDD 20061001

The influence of age on the effects of lifestyle modification and metformin in prevention of diabetes.

The journals of gerontology. Series A, Biological sciences and medical sciences 20061001

Metformin-associated lactic acidosis in a patient with vertebral artery dissection.

Southern medical journal 20061001

Starting insulin therapy in type 2 diabetes: twice-daily biphasic insulin Aspart 30 plus metformin versus once-daily insulin glargine plus glimepiride.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20061001

Thiazolidinediones may not reduce diabetes incidence in type 1 diabetes.

Annals of the New York Academy of Sciences 20061001

Some effect of metformin on insulin resistance in an infant with leprechaunism.

Journal of pediatric endocrinology & metabolism : JPEM 20061001

Acute renal failure from contrast medium: beware patients taking metformin..

BMJ (Clinical research ed.) 20060923

[The metabolic syndrome and sports].

MMW Fortschritte der Medizin 20060921

Strategies to reduce the risk of contrast-induced nephropathy.

The American journal of cardiology 20060918

[Intensified insulin therapy. Is there an alternative to BE count?].

MMW Fortschritte der Medizin 20060914

Effects of metformin on microvascular function and exercise tolerance in women with angina and normal coronary arteries: a randomized, double-blind, placebo-controlled study.

Journal of the American College of Cardiology 20060905

Metformin-induced stimulation of adenosine 5' monophosphate-activated protein kinase (PRKA) impairs progesterone secretion in rat granulosa cells.

Biology of reproduction 20060901

Metformin treatment is effective in obese teenage girls with PCOS.

Human reproduction (Oxford, England) 20060901

The Pro12Ala variant of the PPARG gene is a risk factor for peroxisome proliferator-activated receptor-gamma/alpha agonist-induced edema in type 2 diabetic patients.

The Journal of clinical endocrinology and metabolism 20060901

Changes in patient weight and the impact of antidiabetic therapy during the first 5 years after diagnosis of diabetes mellitus.

Diabetologia 20060901

Utilisation of antihyperglycaemic drugs in ten European countries: different developments and different levels.

Diabetologia 20060901

Metformin influences cardiomyocyte cell death by pathways that are dependent and independent of caspase-3.

Diabetologia 20060901

Effects of melatonin and zinc on lipid profile and renal function in type 2 diabetic patients poorly controlled with metformin.

Journal of pineal research 20060901

Pregnancy outcome after first-trimester exposure to metformin: a meta-analysis.

Fertility and sterility 20060901

Rare case of metformin-induced leukocytoclastic vasculitis.

The Annals of pharmacotherapy 20060901

Plasma dipeptidyl peptidase-IV activity in patients with type-2 diabetes mellitus correlates positively with HbAlc levels, but is not acutely affected by food intake.

European journal of endocrinology 20060901

Glycaemic control without weight gain in insulin requiring type 2 diabetes: 1-year results of the GAME regimen.

Diabetes, obesity & metabolism 20060901

Preventing type 2 diabetes using combination therapy: design and methods of the CAnadian Normoglycaemia Outcomes Evaluation (CANOE) trial.

Diabetes, obesity & metabolism 20060901

Insulin sensitivity during oral glucose tolerance test and its relations to parameters of glucose metabolism and endothelial function in type 2 diabetic subjects under metformin and thiazolidinedione.

Diabetes, obesity & metabolism 20060901

Inhaled insulin as adjunctive therapy in subjects with type 2 diabetes failing oral agents: a controlled proof-of-concept study.

Diabetes, obesity & metabolism 20060901

Should metformin be prescribed to overweight adolescents in whom dietary/behavioural modifications have not helped?

Archives of disease in childhood 20060901

Adherence to preventive medications: predictors and outcomes in the Diabetes Prevention Program.

Diabetes care 20060901

Neither LKB1 nor AMPK are the direct targets of metformin.

Gastroenterology 20060901

Reductions in biomarkers of cardiovascular risk in type 2 diabetes with rosiglitazone added to metformin compared with dose escalation of metformin: an EMPIRE trial sub-study.

Current medical research and opinion 20060901

[Four cases of lactic acidosis following metformin treatment].

Lakartidningen 20060901

Five weeks of treatment with the GLP-1 analogue liraglutide improves glycaemic control and lowers body weight in subjects with type 2 diabetes.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20060901

Predictors of metabolic control at one year in a population of pediatric patients with type 2 diabetes mellitus: a retrospective study.

Journal of pediatric endocrinology & metabolism : JPEM 20060901

Effects of rosiglitazone and metformin on postprandial paraoxonase-1 and monocyte chemoattractant protein-1 in human immunodeficiency virus-infected patients with lipodystrophy.

European journal of pharmacology 20060821

[Improved blood sugar control plus weight loss].

MMW Fortschritte der Medizin 20060817

Metformin treatment to prevent early puberty in girls with precocious pubarche.

The Journal of clinical endocrinology and metabolism 20060801

The effect of the ingestion of Ginkgo biloba extract (EGb 761) on the pharmacokinetics of metformin in non-diabetic and type 2 diabetic subjects--a double blind placebo-controlled, crossover study.

Clinical nutrition (Edinburgh, Scotland) 20060801

The mechanisms involved in the action of metformin in regulating ovarian function in hyperandrogenized mice.

Molecular human reproduction 20060801

Effect of adiponectin on carotid arterial stiffness in type 2 diabetic patients treated with pioglitazone and metformin.

Metabolism: clinical and experimental 20060801

Total cellular calcium and magnesium content of cultured human peripheral blood mononuclear cells following exposure to antidiabetic drugs.

Acta diabetologica 20060801

An open, randomized, parallel-group study to compare the efficacy and safety profile of inhaled human insulin (Exubera) with glibenclamide as adjunctive therapy in patients with type 2 diabetes poorly controlled on metformin.

Diabetes care 20060801

Metformin-pioglitazone and metformin-rosiglitazone effects on non-conventional cardiovascular risk factors plasma level in type 2 diabetic patients with metabolic syndrome.

Journal of clinical pharmacy and therapeutics 20060801

Glycaemic and nonglycaemic effects of pioglitazone in triple oral therapy of patients with type 2 diabetes.

Journal of internal medicine 20060801

Use of metformin for prevention of ovarian hyperstimulation syndrome: a novel approach.

Reproductive biomedicine online 20060801

Metformin reduces lipolysis in primary rat adipocytes stimulated by tumor necrosis factor-alpha or isoproterenol.

Journal of molecular endocrinology 20060801

Metformin-like effect of Salvia officinalis (common sage): is it useful in diabetes prevention?

The British journal of nutrition 20060801

Metformin increases blood flow and forearm glucose uptake in a group of non-obese type 2 diabetes patients.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20060801

Acute alopecia due to metformin treatment for polycystic ovarian syndrome.

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 20060801

Infertility in polycystic ovary syndrome: focus on low-dose gonadotropin treatment.

Endocrine 20060801

Lifestyle choices, diet, and insulin sensitizers in polycystic ovary syndrome.

Endocrine 20060801

Thailand diabetes registry project: glycemic control in Thai type 2 diabetes and its relation to hypoglycemic agent usage.

Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20060801

Metformin beyond diabetes: new life for an old drug.

Current diabetes reviews 20060801

Diagnosis and new approaches in the therapy of gestational diabetes mellitus.

Current diabetes reviews 20060801

Effect of insulin-sensitizing agents in combination with ezetimibe, and valsartan in rats with non-alcoholic fatty liver disease.

World journal of gastroenterology 20060721

Metformin reduces angiotensin-mediated intracellular production of reactive oxygen species in endothelial cells through the inhibition of protein kinase C.

Biochemical pharmacology 20060714

Glucose utilization is suppressed in the gut of insulin-resistant high fat-fed rats and is restored by metformin.

Biochemical pharmacology 20060714

Intestinal permeability of metformin using single-pass intestinal perfusion in rats.

World journal of gastroenterology 20060707

Combined renal replacement therapy for severe metformin-induced lactic acidosis.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20060701

Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle.

American journal of physiology. Endocrinology and metabolism 20060701

Metformin treatment of polycystic ovary syndrome improves health-related quality-of-life, emotional distress and sexuality.

Human reproduction (Oxford, England) 20060701

Adverse reactions to intravenous iodinated contrast media: a primer for radiologists.

Emergency radiology 20060701

Effects of short-term and long-term metformin treatment on menstrual cyclicity in women with polycystic ovary syndrome.

Fertility and sterility 20060701

Global gene expression analysis in liver of obese diabetic db/db mice treated with metformin.

Diabetologia 20060701

Dominant Western health care: type 2 diabetes mellitus.

Journal of transcultural nursing : official journal of the Transcultural Nursing Society 20060701

Expanding role of AMPK in endocrinology.

Trends in endocrinology and metabolism: TEM 20060701

Long-term effects of exenatide therapy over 82 weeks on glycaemic control and weight in over-weight metformin-treated patients with type 2 diabetes mellitus.

Diabetes, obesity & metabolism 20060701

Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes.

Diabetes, obesity & metabolism 20060701

Moxonidine improves glycaemic control in mildly hypertensive, overweight patients: a comparison with metformin.

Diabetes, obesity & metabolism 20060701

Association of insulin resistance with hyperglycemia in streptozotocin-diabetic pigs: effects of metformin at isoenergetic feeding in a type 2-like diabetic pig model.

Metabolism: clinical and experimental 20060701

Inhibitors of the Maillard reaction and AGE breakers as therapeutics for multiple diseases.

Drug discovery today 20060701

Toxicology case of the month: oral hypoglycaemic overdose.

Emergency medicine journal : EMJ 20060701

Low-dose flutamide-metformin therapy for hyperinsulinemic hyperandrogenism in nonobese adolescents and women.

Fertility and sterility 20060701

Ovulation induction in women with polycystic ovary syndrome.

Fertility and sterility 20060701

Insulin-sensitizing agents in women with polycystic ovary syndrome.

Fertility and sterility 20060701

Prenatal growth restraint followed by catch-up of weight: a hyperinsulinemic pathway to polycystic ovary syndrome.

Fertility and sterility 20060701

Treatment with a thiazolidinedione increases eye protrusion in a subgroup of patients with type 2 diabetes.

Clinical endocrinology 20060701

Metformin therapy improves coronary microvascular function in patients with polycystic ovary syndrome and insulin resistance.

Clinical endocrinology 20060701

Case studies in swelling polymeric gastric retentive tablets.

Expert opinion on drug delivery 20060701

The effect of metformin on fat distribution and the metabolic syndrome in women with polycystic ovary syndrome--a randomised, double-blind, placebo-controlled trial.

BJOG : an international journal of obstetrics and gynaecology 20060701

Cheilitis - the only presentation of photosensitivity.

Journal of the European Academy of Dermatology and Venereology : JEADV 20060701

A randomized trial of adding insulin glargine vs. avoidance of insulin in people with Type 2 diabetes on either no oral glucose-lowering agents or submaximal doses of metformin and/or sulphonylureas. The Canadian INSIGHT (Implementing New Strategies with Insulin Glargine for Hyperglycaemia Treatment) Study.

Diabetic medicine : a journal of the British Diabetic Association 20060701

Comparison of insulin lispro mixture 25/75 with insulin glargine during a 24-h standardized test-meal period in patients with Type 2 diabetes.

Diabetic medicine : a journal of the British Diabetic Association 20060701

Comparison of nateglinide and gliclazide in combination with metformin, for treatment of patients with Type 2 diabetes mellitus inadequately controlled on maximum doses of metformin alone.

Diabetic medicine : a journal of the British Diabetic Association 20060701

Beta-cell response to metformin-glibenclamide combination tablets (Glucovance) in patients with type 2 diabetes.

International journal of clinical practice 20060701

Metformin improves menstrual patterns, endocrine and metabolic profile in obese hyperinsulinemic women with a polycystic ovary syndrome.

Prilozi 20060701

Race and medication adherence in Medicaid enrollees with type-2 diabetes.

Journal of the National Medical Association 20060701

Use of metformin for ovulation induction in women who have polycystic ovary syndrome with or without evidence of insulin resistance.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC 20060701

Pioglitazone: an antidiabetic drug with cardiovascular therapeutic effects.

Expert review of cardiovascular therapy 20060701

Neonatal outcome in polycystic ovarian syndrome patients treated with metformin during pregnancy.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 20060701

Development and validation of RP-HPLC method for the analysis of metformin.

Pakistan journal of pharmaceutical sciences 20060701

Effect of N-benzoyl-D-phenylalanine and metformin on insulin receptors in neonatal streptozotocin-induced diabetic rats: studies on insulin binding to erythrocytes.

Archives of physiology and biochemistry 20060701

Effect of clomifene citrate plus metformin and clomifene citrate plus placebo on induction of ovulation in women with newly diagnosed polycystic ovary syndrome: randomised double blind clinical trial.

BMJ (Clinical research ed.) 20060624

Drugs for anovulatory infertility in polycystic ovary syndrome.

BMJ (Clinical research ed.) 20060624

Patient characteristics not described.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20060620

Gerontology: eat your cake and have it.

Nature 20060615

Comparative efficacy of glimepiride and/or metformin with insulin in type 2 diabetes.

Diabetes research and clinical practice 20060601

A systematic review and meta-analysis of randomized controlled trials on metformin co-administration during gonadotrophin ovulation induction or IVF in women with polycystic ovary syndrome.

Human reproduction (Oxford, England) 20060601

Efficacy of combined metformin-letrozole in comparison with metformin-clomiphene citrate in clomiphene-resistant infertile women with polycystic ovarian disease.

Human reproduction (Oxford, England) 20060601

Metformin therapy during puberty delays menarche, prolongs pubertal growth, and augments adult height: a randomized study in low-birth-weight girls with early-normal onset of puberty.

The Journal of clinical endocrinology and metabolism 20060601

Indices of low-grade chronic inflammation in polycystic ovary syndrome and the beneficial effect of metformin.

Human reproduction (Oxford, England) 20060601

The use of metformin for women with PCOS undergoing IVF treatment.

Human reproduction (Oxford, England) 20060601

Long-term metformin treatment stimulates cardiomyocyte glucose transport through an AMP-activated protein kinase-dependent reduction in GLUT4 endocytosis.

Endocrinology 20060601

A mechanism-based disease progression model for comparison of long-term effects of pioglitazone, metformin and gliclazide on disease processes underlying Type 2 Diabetes Mellitus.

Journal of pharmacokinetics and pharmacodynamics 20060601

Randomized, controlled trial of metformin for obesity and insulin resistance in children and adolescents: improvement in body composition and fasting insulin.

The Journal of clinical endocrinology and metabolism 20060601

Metformin inhibits cytokine-induced nuclear factor kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells.

Hypertension (Dallas, Tex. : 1979) 20060601

Insulin-sensitizing agents in polycystic ovary syndrome.

European journal of endocrinology 20060601

An open, randomized, parallel-group study to compare the efficacy and safety profile of inhaled human insulin (Exubera) with metformin as adjunctive therapy in patients with type 2 diabetes poorly controlled on a sulfonylurea.

Diabetes care 20060601

Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome.

Cell metabolism 20060601

Metformin prevents alcohol-induced liver injury in the mouse: Critical role of plasminogen activator inhibitor-1.

Gastroenterology 20060601

Metformin and the fate of fat.

Gastroenterology 20060601

Effects of metformin on insulin resistance, androgen concentration, ovulation and pregnancy rates in women with polycystic ovary syndrome following laparoscopic ovarian drilling.

The journal of obstetrics and gynaecology research 20060601

[Insulin sensitizer--anti-diabetic drugs, metformin and pioglitazone that can improve insulin resistance].

Nihon rinsho. Japanese journal of clinical medicine 20060601

Metformin, vitamin E, and diet for patients with nonalcoholic fatty liver disease.

The American journal of gastroenterology 20060601

Prevention of diabetes and cardiovascular disease in women with PCOS: treatment with insulin sensitizers.

Best practice & research. Clinical endocrinology & metabolism 20060601

Pregnancy complications in PCOS.

Best practice & research. Clinical endocrinology & metabolism 20060601

Thiazolidinedione derivatives in type 2 diabetes mellitus.

The Netherlands journal of medicine 20060601

Effects of metformin on inappropriate LH release in women with polycystic ovarian syndrome and insulin resistance.

Reproductive biomedicine online 20060601

Incretin mimetics and dipeptidyl peptidase-IV inhibitors: a review of emerging therapies for type 2 diabetes.

Diabetes technology & therapeutics 20060601

Symptoms and treatments of polycystic ovary syndrome.

British journal of nursing (Mark Allen Publishing) 20060601

Glycemic control and treatment failure with pioglitazone versus glibenclamide in type 2 diabetes mellitus: a 42-month, open-label, observational, primary care study.

Current medical research and opinion 20060601

[Clinical analysis of 4 treatments for woman polycystic ovarian syndrome with infertility].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20060601

Metformin-diet ameliorates coronary heart disease risk factors and facilitates resumption of regular menses in adolescents with polycystic ovary syndrome.

Journal of pediatric endocrinology & metabolism : JPEM 20060601

Female infertility.

Clinical evidence 20060601

[Therapeutic effects of insulin-sensitizing drugs on nonalcoholic fatty liver disease: experiment with rats].

Zhonghua yi xue za zhi 20060516

Apparent resolution of type 2 diabetes mellitus after initiation of potent antiretroviral therapy in a man from Africa with HIV infection.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20060515

Metformin versus rosiglitazone in the treatment of polycystic ovary syndrome.

European journal of obstetrics, gynecology, and reproductive biology 20060501

Risk of mortality and adverse cardiovascular outcomes in type 2 diabetes: a comparison of patients treated with sulfonylureas and metformin.

Diabetologia 20060501

To: Holstein A, Stumvoll M (2005) Contraindications can damage your health--is metformin a case in point? Diabetologia 48:2454-2459.

Diabetologia 20060501

Two weeks of metformin improves clomiphene citrate-induced ovulation and metabolic profiles in women with polycystic ovary syndrome.

Fertility and sterility 20060501

Chemiluminescence determination of metformin based on hydroxyl radical reaction and molecularly imprinted polymer on-line enrichment.

Analytical and bioanalytical chemistry 20060501

Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Long-term efficacy of sulfonylureas: a United Kingdom Prospective Diabetes Study perspective.

Metabolism: clinical and experimental 20060501

Improvement of glycemic control, triglycerides, and HDL cholesterol levels with muraglitazar, a dual (alpha/gamma) peroxisome proliferator-activated receptor activator, in patients with type 2 diabetes inadequately controlled with metformin monotherapy: A double-blind, randomized, pioglitazone-comparative study.

Diabetes care 20060501

Metformin improves endothelial vascular reactivity in first-degree relatives of type 2 diabetic patients with metabolic syndrome and normal glucose tolerance.

Diabetes care 20060501

Metformin-induced pancreatitis: A possible adverse drug effect during acute renal failure.

Diabetes care 20060501

Metformin hydrochloride and recurrent miscarriage in a woman with polycystic ovary syndrome.

Fertility and sterility 20060501

Lipids in polycystic ovary syndrome: role of hyperinsulinemia and effects of metformin.

American journal of obstetrics and gynecology 20060501

Effects of growth hormone treatment on neutrophil count in children born small for gestational age.

Pediatrics 20060501

Glumetza: once-a-day dosing for management of type 2 diabetes.

The Nurse practitioner 20060501

[Nephrotoxicity after the use of intravenous X-ray contrast media in a type 2 diabetic being treated with metformin].

Ugeskrift for laeger 20060501

Expanding applications for metformin in polycystic ovarian syndrome.

The Journal of pediatrics 20060501

Growth, motor, and social development in breast- and formula-fed infants of metformin-treated women with polycystic ovary syndrome.

The Journal of pediatrics 20060501

Gonadotropin-releasing hormone antagonist and metformin for treatment of polycystic ovary syndrome patients undergoing in vitro fertilization-embryo transfer.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20060501

Exenatide: an incretin mimetic for the treatment of type 2 diabetes mellitus.

Clinical therapeutics 20060501

The effects of combined insulin and metformin therapy in obese patients with diabetes mellitus type 2 in the early stage of the disease.

Bosnian journal of basic medical sciences 20060501

[Factors influencing homocysteineamia in type 2 diabetic patients].

La Tunisie medicale 20060501

Preventing nephropathy induced by contrast medium.

The New England journal of medicine 20060427

Metformin reduces blood pressure and restores endothelial function in aorta of streptozotocin-induced diabetic rats.

Life sciences 20060425

Osteogenic actions of the anti-diabetic drug metformin on osteoblasts in culture.

European journal of pharmacology 20060424

[Effect of fenofibrate and metformin on lipotoxicity in OLETF rat kidney].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20060418

Treatment of nonalcoholic fatty liver disease.

World journal of gastroenterology 20060414

Metformin and type 2 diabetes mellitus.

Canadian family physician Medecin de famille canadien 20060410

Hirsutism.

The New England journal of medicine 20060406

Bax translocates to mitochondria of heart cells during simulated ischaemia: involvement of AMP-activated and p38 mitogen-activated protein kinases.

The Biochemical journal 20060401

Transporters as a determinant of drug clearance and tissue distribution.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20060401

Effects of rosiglitazone and metformin on pancreatic beta cell gene expression.

Diabetologia 20060401

LKB1: a sweet side to Peutz-Jeghers syndrome?

Trends in molecular medicine 20060401

Use of an electronic medical record to detect patients at high risk of metformin-induced lactic acidosis.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20060401

Metformin extended release for the treatment of type 2 diabetes mellitus.

Expert opinion on pharmacotherapy 20060401

Optimal treatments for the metabolic syndrome.

Arteriosclerosis, thrombosis, and vascular biology 20060401

5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and metformin inhibit hepatic glucose phosphorylation by an AMP-activated protein kinase-independent effect on glucokinase translocation.

Diabetes 20060401

Efficacy, tolerability, and safety of a novel once-daily extended-release metformin in patients with type 2 diabetes.

Diabetes care 20060401

The association among autonomic nervous system function, incident diabetes, and intervention arm in the Diabetes Prevention Program.

Diabetes care 20060401

Pregnancy outcome in infertile patients with polycystic ovary syndrome who were treated with metformin.

Fertility and sterility 20060401

Ovulation induction in infertile patients with polycystic ovary syndrome.

Minerva ginecologica 20060401

[From cancer to diabetes treatment : the tumor suppressor LKB1 as a new pharmacological target].

Medecine sciences : M/S 20060401

[Regulation of energy metabolism by AMPK: a novel therapeutic approach for the treatment of metabolic and cardiovascular diseases].

Medecine sciences : M/S 20060401

Effects of metformin on the glycemic control, lipid profile, and arterial blood pressure of type 2 diabetic patients with metabolic syndrome already on insulin.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20060401

Severe acidosis in patients taking metformin--rapid reversal and survival despite high APACHE score.

Diabetic medicine : a journal of the British Diabetic Association 20060401

Diabetes with partial lipodystrophy following sclerodermatous chronic graft vs. host disease.

Diabetic medicine : a journal of the British Diabetic Association 20060401

Insulin secretion and sensitivity as determinants of HbA1c in type 2 diabetes.

European journal of clinical investigation 20060401

Study on a new precolumn derivatization method in the determination of metformin hydrochloride.

Journal of chromatographic science 20060401

No more surrogate end-points in randomised trials: the PCOSMIC trial protocol for women with polycystic ovary syndrome using metformin for infertility with clomiphene.

The Australian & New Zealand journal of obstetrics & gynaecology 20060401

Glimepiride versus pioglitazone combination therapy in subjects with type 2 diabetes inadequately controlled on metformin monotherapy: results of a randomized clinical trial.

Current medical research and opinion 20060401

Outcome of clinical pregnancies after ovulation induction using metformin.

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 20060401

A simple method to evaluate the risk of heart failure during glitazone therapy.

Diabetes technology & therapeutics 20060401

Effect of metformin on survival rate in experimental sepsis.

Diabetes & metabolism 20060401

Ovulatory disorders and infertility.

The Journal of reproductive medicine 20060401

Elimination of metformin-croscarmellose sodium interaction by competition.

International journal of pharmaceutics 20060327

Dried blood spot liquid chromatography assay for therapeutic drug monitoring of metformin.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060307

Aminoguanidine and metformin prevent the reduced rate of HDL-mediated cell cholesterol efflux induced by formation of advanced glycation end products.

The international journal of biochemistry & cell biology 20060301

Metformin prevents endotoxin-induced liver injury after partial hepatectomy.

The Journal of pharmacology and experimental therapeutics 20060301

Early effects of metformin in women with polycystic ovary syndrome: a prospective randomized, double-blind, placebo-controlled trial.

The Journal of clinical endocrinology and metabolism 20060301

Metformin inhibits proinflammatory responses and nuclear factor-kappaB in human vascular wall cells.

Arteriosclerosis, thrombosis, and vascular biology 20060301

Metformin-glibenclamide versus metformin plus rosiglitazone in patients with type 2 diabetes inadequately controlled on metformin monotherapy.

Diabetes, obesity & metabolism 20060301

Tissue-specific regulation of malonyl-CoA decarboxylase activity in OLETF rats.

Diabetes, obesity & metabolism 20060301

Differential effect of glimepiride and rosiglitazone on metabolic control of type 2 diabetic patients treated with metformin: a randomized, double-blind, clinical trial.

Diabetes, obesity & metabolism 20060301

Insulin glargine or NPH combined with metformin in type 2 diabetes: the LANMET study.

Diabetologia 20060301

Effects of metformin and thiazolidinediones on suppression of hepatic glucose production and stimulation of glucose uptake in type 2 diabetes: a systematic review.

Diabetologia 20060301

Plasminogen activator inhibitor activity, 4G5G polymorphism of the plasminogen activator inhibitor 1 gene, and first-trimester miscarriage in women with polycystic ovary syndrome.

Metabolism: clinical and experimental 20060301

Insulin sensitizing pharmacotherapy for prevention of myocardial infarction in patients with diabetes mellitus.

The American journal of cardiology 20060301

Metformin use and diabetic pregnancy-has its time come?

Diabetic medicine : a journal of the British Diabetic Association 20060301

Pregnancy in women with Type 2 diabetes: who takes metformin and what is the outcome?

Diabetic medicine : a journal of the British Diabetic Association 20060301

Effect of pregnancy on the pharmacokinetics of metformin.

Diabetic medicine : a journal of the British Diabetic Association 20060301

Metformin-related vitamin B12 deficiency.

Age and ageing 20060301

Beneficial effect of metformin on pregnancy outcome in women with polycystic ovary syndrome is not associated with major changes in C-reactive protein levels or indices of coagulation.

Fertility and sterility 20060301

Metformin restores leptin sensitivity in high-fat-fed obese rats with leptin resistance.

Diabetes 20060301

Novel mechanism for plasma glucose-lowering action of metformin in streptozotocin-induced diabetic rats.

Diabetes 20060301

Stability of body weight in type 2 diabetes.

Diabetes care 20060301

Treatment escalation and rise in HbA1c following successful initial metformin therapy.

Diabetes care 20060301

Triple therapy in type 2 diabetes: insulin glargine or rosiglitazone added to combination therapy of sulfonylurea plus metformin in insulin-naive patients.

Diabetes care 20060301

Role of the N, N'-dimethylbiguanide metformin in the treatment of female prepuberal BALB/c mice hyperandrogenized with dehydroepiandrosterone.

Reproduction (Cambridge, England) 20060301

Randomized placebo-controlled trial of metformin for adolescents with polycystic ovary syndrome.

Archives of pediatrics & adolescent medicine 20060301

Metformin and heart failure: innocent until proven guilty.

Diabetes care 20060301

Therapy of NAFLD: insulin sensitizing agents.

Journal of clinical gastroenterology 20060301

Metformin for prevention of weight gain and insulin resistance with olanzapine: a double-blind placebo-controlled trial.

Canadian journal of psychiatry. Revue canadienne de psychiatrie 20060301

Metformin-associated lactic acidosis treated with continuous renal replacement therapy.

Clinical therapeutics 20060301

Is metformin or clomiphene citrate more effective for ovulation induction in polycystic ovary syndrome?

Nature clinical practice. Endocrinology & metabolism 20060301

[Diagnosis of vitamin B12 deficiency revised].

Nederlands tijdschrift voor geneeskunde 20060225

Metformin use during the first trimester of pregnancy. Is it safe?

Canadian family physician Medecin de famille canadien 20060210

[Prevention of contrast nephropathy; guidelines from the Department Nephrology of the University Medical Centre Groningen].

Nederlands tijdschrift voor geneeskunde 20060204

Effect of ecdysterone on glucose metabolism in vitro.

Life sciences 20060202

Discontinuous low-dose flutamide-metformin plus an oral or a transdermal contraceptive in patients with hyperinsulinaemic hyperandrogenism: normalizing effects on CRP, TNF-alpha and the neutrophil/lymphocyte ratio.

Human reproduction (Oxford, England) 20060201

Uterine effects of metformin administration in anovulatory women with polycystic ovary syndrome.

Human reproduction (Oxford, England) 20060201

Mitochondrial dysfunction as the cause of the failure to precondition the diabetic human myocardium.

Cardiovascular research 20060201

The Indian Diabetes Prevention Programme shows that lifestyle modification and metformin prevent type 2 diabetes in Asian Indian subjects with impaired glucose tolerance (IDPP-1).

Diabetologia 20060201

Metformin improves atypical protein kinase C activation by insulin and phosphatidylinositol-3,4,5-(PO4)3 in muscle of diabetic subjects.

Diabetologia 20060201

Population pharmacokinetics of metformin in late pregnancy.

Therapeutic drug monitoring 20060201

Variability in renal clearance of substrates for renal transporters in chinese subjects.

Journal of clinical pharmacology 20060201

The effect of obesity on glycaemic response to metformin or sulphonylureas in Type 2 diabetes.

Diabetic medicine : a journal of the British Diabetic Association 20060201

Low insulin-like growth factor-II levels predict weight gain in normal weight subjects with type 2 diabetes.

The American journal of medicine 20060201

Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase.

Diabetes 20060201

Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin.

Diabetes care 20060201

Improving metabolic control leads to better working memory in adults with type 2 diabetes.

Diabetes care 20060201

Lifestyle intervention is associated with lower prevalence of urinary incontinence: the Diabetes Prevention Program.

Diabetes care 20060201

Metformin in pregnancy: its time has not yet come.

Diabetes care 20060201

Clinical Research Network launches TONIC trial for treatment of nonalcoholic fatty liver disease in children.

Journal of pediatric gastroenterology and nutrition 20060201

Fulfilling our assignment to improve the health of all: good science just isn't enough.

Annals of behavioral medicine : a publication of the Society of Behavioral Medicine 20060201

Comparison of lipid profiles and lipoprotein a levels in patients with type 2 diabetes mellitus during oral hypoglycemic or insulin therapy.

Saudi medical journal 20060201

Understanding the causes and management of hirsutism.

Nursing times 20060201

Metformin increases insulin sensitivity and plasma beta-endorphin in human subjects.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20060201

Medication costs as a primary cause of nonadherence in the elderly.

The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists 20060201

A randomized controlled trial of the efficacy of rosiglitazone and clomiphene citrate versus metformin and clomiphene citrate in women with clomiphene citrate-resistant polycystic ovary syndrome.

Fertility and sterility 20060201

Insulin resistance and improvements in signal transduction.

Endocrine 20060201

[Metformin hydrochloride ameliorates adiponectin levels and insulin sensitivity in adolescents with metabolic syndrome].

Zhonghua er ke za zhi = Chinese journal of pediatrics 20060201

The ROS production induced by a reverse-electron flux at respiratory-chain complex 1 is hampered by metformin.

Journal of bioenergetics and biomembranes 20060201

Pioglitazone/metformin (Actoplus met).

The Medical letter on drugs and therapeutics 20060130

Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.

The Cochrane database of systematic reviews 20060125

Effect of high-fat diet and metformin treatment on ventilation and sleep apnea in non-obese rats.

Respiratory physiology & neurobiology 20060125

[Traditional contraindications to the use of metformin -- more harmful than beneficial?].

Deutsche medizinische Wochenschrift (1946) 20060120

Review article: Drug therapy for non-alcoholic fatty liver disease.

Alimentary pharmacology & therapeutics 20060115

Increased plasma adiponectin in response to pioglitazone does not result from increased gene expression.

American journal of physiology. Endocrinology and metabolism 20060101

Combined lifestyle modification and metformin in obese patients with polycystic ovary syndrome. A randomized, placebo-controlled, double-blind multicentre study.

Human reproduction (Oxford, England) 20060101

Effect of rosiglitazone and nateglinide on serum glucose and lipid profile alone or in combination with the biguanide metformin in diabetic rats.

Pharmacological research 20060101

Thyrotropin suppression by metformin.

The Journal of clinical endocrinology and metabolism 20060101

Biphasic insulin aspart 30 plus metformin: an effective combination in type 2 diabetes.

Diabetes, obesity & metabolism 20060101

Effects of metformin and oleic acid on adipocyte expression of resistin.

Diabetes, obesity & metabolism 20060101

Long-term glycaemic efficacy and weight changes associated with thiazolidinediones when added at an advanced stage of type 2 diabetes.

Diabetes, obesity & metabolism 20060101

Retrospective review of metformin in inpatients and outpatients at the University of Michigan.

Diabetes care 20060101

Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells.

Diabetes 20060101

Natural antibiotics and insulin sensitivity: the role of bactericidal/permeability-increasing protein.

Diabetes 20060101

Diabetes treatments have differential effects on nontraditional cardiovascular risk factors.

Journal of diabetes and its complications 20060101

Low-dose flutamide-metformin therapy for hyperinsulinemic hyperandrogenism in non-obese adolescents and women.

Human reproduction update 20060101

Higher-order multiple pregnancy associated with metformin in women with polycystic ovary syndrome: two cases and review of the literature.

Fertility and sterility 20060101

Metformin-associated lactic acidosis precipitated by acute renal failure.

The American journal of the medical sciences 20060101

Severe lactic acidosis treated with prolonged hemodialysis: recovery after massive overdoses of metformin.

Seminars in dialysis 20060101

Insulin dynamics predict body mass index and z-score response to insulin suppression or sensitization pharmacotherapy in obese children.

The Journal of pediatrics 20060101

Metformin delays the manifestation of diabetes and vascular dysfunction in Goto-Kakizaki rats by reduction of mitochondrial oxidative stress.

Diabetes/metabolism research and reviews 20060101

Insulin-lowering agents inhibit synthesis of testosterone in ovaries of DHEA-induced PCOS rats.

Gynecologic and obstetric investigation 20060101

Metformin administration modulates neurosteroids secretion in non-obese amenorrhoic patients with polycystic ovary syndrome.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20060101

Anti-diabetic drug use and the risk of motor vehicle crash in the elderly.

The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique 20060101

[Glucose control in cardiac disease].

Clinical research in cardiology : official journal of the German Cardiac Society 20060101

An update on the Diabetes Prevention Program.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20060101

Can glycemic targets be achieved-- in particular with two daily injections of a mix of intermediate- and short-acting insulin?

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20060101

In vitro availability of metformin in presence of h(2) receptor antagonists.

Pakistan journal of pharmaceutical sciences 20060101

Three-year mortality in diabetic patients treated with different combinations of insulin secretagogues and metformin.

Diabetes/metabolism research and reviews 20060101

Exenatide elicits sustained glycaemic control and progressive reduction of body weight in patients with type 2 diabetes inadequately controlled by sulphonylureas with or without metformin.

Diabetes/metabolism research and reviews 20060101

Combined n-benzoyl-d-phenylalanine and metformin treatment reverses changes in the fatty acid composition of streptozotocin diabetic rats.

Journal of basic and clinical physiology and pharmacology 20060101

The case for combination therapy as first-line treatment for the type 2 diabetic patient.

Treatments in endocrinology 20060101

Spotlight on pioglitazone in type 2 diabetes mellitus.

Treatments in endocrinology 20060101

[A clinical case of development of lactic acid acidosis in a diabetic patient taking metformin].

Anesteziologiia i reanimatologiia 20060101

AMPK or ZMPK?

Medical hypotheses 20060101

Cost-effectiveness of rosiglitazone combination therapy for the treatment of type 2 diabetes mellitus in the UK.

PharmacoEconomics 20060101

Cost-effectiveness of rosiglitazone oral combination for the treatment of type 2 diabetes in Germany.

PharmacoEconomics 20060101

Lifetime health consequences and cost-effectiveness of rosiglitazone in combination with metformin for the treatment of type 2 diabetes in Spain.

PharmacoEconomics 20060101

Polycystic ovary syndrome and metformin in pregnancy.

Acta obstetricia et gynecologica Scandinavica 20060101

Pharmacological and surgical intervention for the prevention of diabetes.

Nestle Nutrition workshop series. Clinical & performance programme 20060101

Metformin prevents embryonic resorption induced by hyperandrogenisation with dehydroepiandrosterone in mice.

Reproduction, fertility, and development 20060101

Assessment of prescribing information for generic drugs manufactured in the Middle East and marketed in Saudi Arabia.

Annals of Saudi medicine 20060101

The treatment of type 2 diabetes mellitus in youth : which therapies?

Treatments in endocrinology 20060101

Spontaneous singleton and twin pregnancy in two patients with polycystic ovary syndrome and type 2 diabetes following treatment with metformin combined with rosiglitazone.

Annals of Saudi medicine 20060101

Lack of pharmacokinetic interaction for ISIS 113715, a 2'-0-methoxyethyl modified antisense oligonucleotide targeting protein tyrosine phosphatase 1B messenger RNA, with oral antidiabetic compounds metformin, glipizide or rosiglitazone.

Clinical pharmacokinetics 20060101

Glycoprotein changes in non-insulin dependent diabetic rats: effect of N-benzoyl-D-phenylalanine and metformin.

Therapie 20060101

[Probability of control of the patient with diabetes exclusively treated with pharmacological therapy].

Revista medica del Instituto Mexicano del Seguro Social 20060101

Metformin and pioglitazone: Effectively treating insulin resistance.

Current medical research and opinion 20060101

A fixed-dose combination of pioglitazone and metformin: A promising alternative in metabolic control.

Current medical research and opinion 20060101

Relationship of oral antihyperglycemic (sulfonylurea or metformin) medication adherence and hemoglobin A1c goal attainment for HMO patients enrolled in a diabetes disease management program.

Journal of managed care pharmacy : JMCP 20060101

Effects of glibornuride versus metformin on eye lenses and skin in experimental diabetes.

Arzneimittel-Forschung 20060101

Obesity is associated with altered metabolic and reproductive activity in the mare: effects of metformin on insulin sensitivity and reproductive cyclicity.

Reproduction, fertility, and development 20060101

Course of glycaemia in poorly controlled type 2 diabetes patients 2.5 years after optimizing oral treatment in general practice.

The European journal of general practice 20060101

The use of insulin sensitising agents in ovulation induction in women with polycystic ovary syndrome.

Hormones (Athens, Greece) 20060101

Treatment of type 2 diabetes. Use of fixed-dose oral combinations.

Postgraduate medicine 20060101

The role of continuous renal replacement therapy in the treatment of poisoning.

Seminars in dialysis 20060101

Association of diet alone, insulin, sulfonylureas, metformin, and thiazolidinediones with the severity of coronary artery disease in patients with diabetes mellitus.

American journal of therapeutics 20060101

[Quality of ambulatory care of non-insulin dependent diabetic patients].

Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit 20060101

Polycystic ovary syndrome in adolescents: current and future treatment options.

Paediatric drugs 20060101

Pioglitazone/metformin.

Drugs 20060101

5 '-Amino-4-imidazolecarboxamide riboside induces apoptosis in human neuroblastoma cells via the mitochondrial pathway.

Nucleosides, nucleotides & nucleic acids 20060101

Hypoglycemia in Type 2 diabetic patients randomized to and maintained on monotherapy with diet, sulfonylurea, metformin, or insulin for 6 years from diagnosis: UKPDS73.

Journal of diabetes and its complications 20060101

Update on the management of polycystic ovary syndrome.

Pharmacological reports : PR 20060101

Type 2 diabetes mellitus: a review of pharmacological treatment.

Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria 20060101

From the World Congress of Cardiology, Barcelona, 2006--Support for wider metformin usage in type 2 diabetes.

Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners 20060101

Effects of rosiglitazone and pioglitazone combined with metformin on the prothrombotic state of patients with type 2 diabetes mellitus and metabolic syndrome.

The Journal of international medical research 20060101

Utilization of diabetes medication and cost of testing supplies in Saskatchewan, 2001.

BMC health services research 20060101

[Clinical, hormonal and biochemical changes after treatment with metformin and weight reduction in women with polycystic ovary syndrome].

Akusherstvo i ginekologiia 20060101

The role of metformin in the treatment of polycystic ovary syndrome (PCOS).

Chang Gung medical journal 20060101

Ovarian stimulation in polycystic ovarian syndrome.

International surgery 20060101

[Effect of 6-month treatment with oral antiandrogen alone and in combination with insulin sensitizers on body composition, hormonal and metabolic parameters in women with polycystic ovary syndrome (PCOS) in order to determine therapeutic strategy].

Akusherstvo i ginekologiia 20060101

Sudden reversible osmotic lens damage ('sugar cracks') after initiation of metformin.

The New England journal of medicine 20051215

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.

Science (New York, N.Y.) 20051209

The beneficial effects of insulin and metformin on in vitro developmental potential of porcine oocytes and embryos.

Biology of reproduction 20051201

The effects of rosiglitazone and metformin on oxidative stress and homocysteine levels in lean patients with polycystic ovary syndrome.

Human reproduction (Oxford, England) 20051201

Rosiglitazone treatment increases subcutaneous adipose tissue glucose uptake in parallel with perfusion in patients with type 2 diabetes: a double-blind, randomized study with metformin.

The Journal of clinical endocrinology and metabolism 20051201

[Therapeutic options for nonalcoholic fatty liver disease and steatohepatitis].

Der Internist 20051201

Long-term effects on lipids and lipoproteins of pioglitazone versus gliclazide addition to metformin and pioglitazone versus metformin addition to sulphonylurea in the treatment of type 2 diabetes.

Diabetologia 20051201

Contraindications can damage your health--is metformin a case in point?

Diabetologia 20051201

Insulin signalling downstream of protein kinase B is potentiated by 5'AMP-activated protein kinase in rat hearts in vivo.

Diabetologia 20051201

Type 2 diabetes mellitus in youth: the complete picture to date.

Pediatric clinics of North America 20051201

Insulin analogues in children and teens with type 1 diabetes: advantages and caveats.

Pediatric clinics of North America 20051201

Oral agents in managing diabetes mellitus in children and adolescents.

Pediatric clinics of North America 20051201

Predictive value of glucose-insulin ratio in PCOS and profile of women who will benefit from metformin therapy: obese, lean, hyper or normoinsulinemic?

European journal of obstetrics, gynecology, and reproductive biology 20051201

Metformin administration and laparoscopic ovarian drilling improve ovarian response to clomiphene citrate (CC) in oligo-anovulatory CC-resistant women with polycystic ovary syndrome.

Clinical endocrinology 20051201

Effects of rosiglitazone added to submaximal doses of metformin compared with dose escalation of metformin in type 2 diabetes: the EMPIRE Study.

Current medical research and opinion 20051201

[Effects of metformin on fatty liver in insulin-resistant rats].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20051201

Description and preliminary evaluation of a Multiagent Intelligent Dosing System (MAIDS) to manage combination insulin-oral agent therapy in type 2 diabetes.

Diabetes technology & therapeutics 20051201

[Metformin in the treatment of type 2 diabetes in overweighted or obese patients].

Anales de medicina interna (Madrid, Spain : 1984) 20051201

The effects of rosiglitazone and metformin on insulin resistance and serum androgen levels in obese and lean patients with polycystic ovary syndrome.

Journal of endocrinological investigation 20051201

Management of the metabolic syndrome.

Panminerva medica 20051201

Possible metformin-induced hepatotoxicity.

The American journal of geriatric pharmacotherapy 20051201

[Advance in treatment of polycystic ovary syndrome].

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20051201

[Effects of metformin on endothelial dysfunction of the renal circulation resulting from acute hyperglycemia in non-diabetic rabbits].

Arquivos brasileiros de endocrinologia e metabologia 20051201

Glycaemic control in type 2 diabetes.

Clinical evidence 20051201

Polycystic ovary syndrome.

Clinical evidence 20051201

Medicine. Cancer-suppressing enzyme adds a link to type 2 diabetes.

Science (New York, N.Y.) 20051125

Identification of potential caloric restriction mimetics by microarray profiling.

Physiological genomics 20051117

New drugs.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20051115

Inflammatory markers and the metabolic syndrome.

Atherosclerosis 20051101

Improvement in endothelial structure and function after metformin treatment in young normal-weight women with polycystic ovary syndrome: results of a 6-month study.

The Journal of clinical endocrinology and metabolism 20051101

Combination therapy using metformin or thiazolidinediones and insulin in the treatment of diabetes mellitus.

Diabetes, obesity & metabolism 20051101

Metformin revisited: re-evaluation of its properties and role in the pharmacopoeia of modern antidiabetic agents.

Diabetes, obesity & metabolism 20051101

Treating insulin resistance in type 2 diabetes with metformin and thiazolidinediones.

Diabetes, obesity & metabolism 20051101

Review article: the treatment of fatty liver disease associated with the metabolic syndrome.

Alimentary pharmacology & therapeutics 20051101

Autosampler programming for improved sample throughput in liquid chromatography/mass spectrometry.

Clinical chemistry 20051101

Simultaneous determination of metformin and gliclazide in human plasma by liquid chromatography-tandem mass spectrometry: application to a bioequivalence study of two formulations in healthy volunteers.

Journal of mass spectrometry : JMS 20051101

Insulin-sensitisers in the treatment of polycystic ovary syndrome.

Expert opinion on pharmacotherapy 20051101

Effect of metformin on the growth hormone response to growth hormone-releasing hormone in obese women with polycystic ovary syndrome.

Fertility and sterility 20051101

Glumetza offers once-a-day dosing for type 2 diabetes patients.

The Nurse practitioner 20051101

Lactic acidosis. Lactic acidosis associated with metformin use in treatment of type 2 diabetes mellitus.

Geriatrics 20051101

Impact of metformin therapy in patients with polycystic ovarian syndrome.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 20051101

Simultaneous determination of metformin and glimepride in pharmaceutical dosage form by reverse-phase liquid chromatography.

Journal of separation science 20051101

Drug treatment of type 2 diabetes in adults.

Nursing standard (Royal College of Nursing (Great Britain) : 1987) 20051101

The 'worried-well', insulin resistance and metformin therapy.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 20051101

Metformin: old wine in new bottle--evolving technology and therapy in diabetes.

The Journal of the Association of Physicians of India 20051101

Drug therapy in prediabetes.

Journal of the Indian Medical Association 20051101

Prevention of type 2 diabetes in the prediabetic population.

Journal of the Indian Medical Association 20051101

Metformin treatment restores the altered microvascular reactivity in neonatal streptozotocin-induced diabetic rats increasing NOS activity, but not NOS expression.

Life sciences 20051007

The Diabetes Prevention Program and the metabolic syndrome.

Annals of internal medicine 20051004

The Diabetes Prevention Program and the metabolic syndrome.

Annals of internal medicine 20051004

Antidiabetic therapy and the risk of heart failure in type 2 diabetic patients: an independent effect or confounding by indication.

Pharmacoepidemiology and drug safety 20051001

A randomized controlled trial evaluating metformin pre-treatment and co-administration in non-obese insulin-resistant women with polycystic ovary syndrome treated with controlled ovarian stimulation plus timed intercourse or intrauterine insemination.

Human reproduction (Oxford, England) 20051001

Safety and tolerability of pioglitazone, metformin, and gliclazide in the treatment of type 2 diabetes.

Diabetes research and clinical practice 20051001

Rosiglitazone effects on blood pressure and metabolic parameters in nondipper diabetic patients.

Diabetes research and clinical practice 20051001

Patient-tailored conventional ovulation induction algorithms in anovulatory infertility.

Trends in endocrinology and metabolism: TEM 20051001

Acute myopathy in a type 2 diabetic patient on combination therapy with metformin, fenofibrate and rosiglitazone.

Diabetologia 20051001

Fulminant lactic acidosis in two patients with Type 2 diabetes treated with metformin.

Diabetic medicine : a journal of the British Diabetic Association 20051001

Effect of N-benzoyl-d-phenylalanine on lipid profile in liver of neonatal streptozotocin diabetic rats.

Fundamental & clinical pharmacology 20051001

Rosiglitazone plus metformin is effective and well tolerated in clinical practice: results from large observational studies in people with type 2 diabetes.

International journal of clinical practice 20051001

Improved clinical outcomes associated with metformin in patients with diabetes and heart failure.

Diabetes care 20051001

Metformin and heart failure: innocent until proven guilty.

Diabetes care 20051001

Metformin alters insulin signaling and viability of human granulosa cells.

Fertility and sterility 20051001

Metformin.

Nursing times 20051001

Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1.

Drug metabolism and pharmacokinetics 20051001

Cancer protection.

Harvard health letter 20051001

Insulin in type 2 diabetes: a useful alternative despite limited assessment based on surrogate endpoints.

Prescrire international 20051001

Effects of insulin sensitizers on islet transplantation.

Transplantation proceedings 20051001

Triple therapy with glimepiride in patients with type 2 diabetes mellitus inadequately controlled by metformin and a thiazolidinedione: results of a 30-week, randomized, double-blind, placebo-controlled, parallel-group study.

Clinical therapeutics 20051001

Rosiglitazone/metformin fixed-dose combination compared with uptitrated metformin alone in type 2 diabetes mellitus: a 24-week, multicenter, randomized, double-blind, parallel-group study.

Clinical therapeutics 20051001

Investigation of the pharmacokinetic and pharmacodynamic interactions between memantine and glyburide/metformin in healthy young subjects: a single-center, multiple-dose, open-label study.

Clinical therapeutics 20051001

Goat's rue - French lilac - Italian fitch - Spanish sainfoin: gallega officinalis and metformin: the Edinburgh connection.

The journal of the Royal College of Physicians of Edinburgh 20051001

Determination of metformin in human plasma by high-performance liquid chromatography.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050925

[Metformin for type-2 diabetes mellitus. Systematic review and meta-analysis].

Atencion primaria 20050915

[The rehabilitation of metformin].

Atencion primaria 20050915

Hypoglycemic effect of Malmea depressa root on streptozotocin diabetic rats.

Journal of ethnopharmacology 20050914

[Metformin-associated lactic acidosis in a patient with pre-existing risk factors].

Praxis 20050907

Summaries for patients. HIV lipodystrophy: rosiglitazone or metformin?

Annals of internal medicine 20050906

Comparison of rosiglitazone and metformin for treating HIV lipodystrophy: a randomized trial.

Annals of internal medicine 20050906

Ameliorating effect of FK614, a novel nonthiazolidinedione peroxisome proliferator-activated receptor gamma agonist, on insulin resistance in Zucker fatty rat.

European journal of pharmacology 20050905

High neutrophil count in girls and women with hyperinsulinaemic hyperandrogenism: normalization with metformin and flutamide overcomes the aggravation by oral contraception.

Human reproduction (Oxford, England) 20050901

Serum and follicular fluid levels of soluble Fas, soluble Fas ligand and apoptosis of luteinized granulosa cells in PCOS patients undergoing IVF.

Human reproduction (Oxford, England) 20050901

Rosiglitazone Evaluated for Cardiac Outcomes and Regulation of Glycaemia in Diabetes (RECORD): study design and protocol.

Diabetologia 20050901

Metformin reduces C-reactive protein but not complement factor C3 in overweight patients with Type 2 diabetes mellitus.

Diabetic medicine : a journal of the British Diabetic Association 20050901

Insulin initiation in Type 2 diabetes.

Diabetic medicine : a journal of the British Diabetic Association 20050901

Management of diabetes during Ramadan.

Diabetic medicine : a journal of the British Diabetic Association 20050901

Metformin improves endothelial function in patients with metabolic syndrome.

Journal of internal medicine 20050901

Stockpiling of ovarian follicles and the response to rosiglitazone.

Diabetes care 20050901

Severe lactic acidosis complicating metformin overdose successfully treated with high-volume venovenous hemofiltration and aggressive alkalinization.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20050901

Bioequivalence studies with metformin: comparability of reference tablets from different origins.

International journal of clinical pharmacology and therapeutics 20050901

Plasminogen activator inhibitor 1 and miscarriage after metformin treatment and laparoscopic ovarian drilling in patients with polycystic ovary syndrome.

Fertility and sterility 20050901

Metformin treatment in patients with polycystic ovary syndrome undergoing in vitro fertilization: a prospective randomized trial.

Fertility and sterility 20050901

The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenografts.

Molecular cancer therapeutics 20050901

Metformin as treatment for overweight and obese adults: a systematic review.

Annals of family medicine 20050901

Effect of metformin and rosiglitazone on lipid metabolism in HIV infected patients receiving protease inhibitor containing HAART.

Acta dermatovenerologica Alpina, Pannonica, et Adriatica 20050901

Insulin resistance in polycystic ovarian disease.

Southern medical journal 20050901

Increased A-ring reduction of glucocorticoids in obese Zucker rats: effects of insulin sensitization.

Obesity research 20050901

Long-term effects of glimepiride or rosiglitazone in combination with metformin on blood pressure control in type 2 diabetic patients affected by the metabolic syndrome: a 12-month, double-blind, randomized clinical trial.

Clinical therapeutics 20050901

The effects of rosiglitazone and metformin on menstrual cyclicity and hirsutism in polycystic ovary syndrome.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20050901

Metformin's contraindications should be contraindicated.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20050830

Metformin's contraindications: needed for now.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20050830

[Triple oral therapy in type 2 diabetes].

Revue medicale suisse 20050824

Metformin reduces adiponectin protein expression and release in 3T3-L1 adipocytes involving activation of AMP activated protein kinase.

European journal of pharmacology 20050822

[Polycystic ovary syndrome. New pathophysiological discoveries--therapeutic consequences].

Ugeskrift for laeger 20050822

Summaries for patients. The outcomes and costs of diabetes prevention with a diet and exercise program or metformin: a computer model.

Annals of internal medicine 20050816

Clinical outcomes and cost-effectiveness of strategies for managing people at high risk for diabetes.

Annals of internal medicine 20050816

Safety of metformin use during the first trimester.

Canadian family physician Medecin de famille canadien 20050810

[Type 2 diabetic patient with reduced beta-cell function. New substance class: incretin-mimetics].

MMW Fortschritte der Medizin 20050804

Metformin and weight loss in obese women with polycystic ovary syndrome: comparison of doses.

The Journal of clinical endocrinology and metabolism 20050801

Effect of buformin and metformin on formation of advanced glycation end products by methylglyoxal.

Clinica chimica acta; international journal of clinical chemistry 20050801

Drugs for diabetes.

Treatment guidelines from the Medical Letter 20050801

Changes in liver tests during 1-year treatment of patients with Type 2 diabetes with pioglitazone, metformin or gliclazide.

Diabetic medicine : a journal of the British Diabetic Association 20050801

Comparison of metabolic effects of pioglitazone, metformin, and glimepiride over 1 year in Japanese patients with newly diagnosed Type 2 diabetes.

Diabetic medicine : a journal of the British Diabetic Association 20050801

Insulin pump therapy vs. multiple daily injections in obese Type 2 diabetic patients.

Diabetic medicine : a journal of the British Diabetic Association 20050801

Long-term effects of pioglitazone and metformin on insulin sensitivity in patients with Type 2 diabetes mellitus.

Diabetic medicine : a journal of the British Diabetic Association 20050801

Improved meal-related beta-cell function and insulin sensitivity by the dipeptidyl peptidase-IV inhibitor vildagliptin in metformin-treated patients with type 2 diabetes over 1 year.

Diabetes care 20050801

Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazone.

Diabetes 20050801

Role of insulin secretion and sensitivity in the evolution of type 2 diabetes in the diabetes prevention program: effects of lifestyle intervention and metformin.

Diabetes 20050801

Usefulness of the addition of metformin to insulin in pediatric patients with type 1 diabetes mellitus.

Pediatrics international : official journal of the Japan Pediatric Society 20050801

Pioglitazone, rosiglitazone, and rosiglitazone + metformin: new drugs. Glitazone + oral antidiabetic combination: inadequately evaluated.

Prescrire international 20050801

The patient with polycystic ovary syndrome.

The Practitioner 20050801

Effects of antidiabetic treatment with metformin and insulin on serum and adipose tissue adiponectin levels in db/db mice.

Endocrine journal 20050801

Markedly improved glycemic control and enhanced insulin sensitivity in a patient with type 2 diabetes complicated by a suprasellar tumor treated with pioglitazone and metformin.

Internal medicine (Tokyo, Japan) 20050801

Randomized controlled trial evaluating response to metformin versus standard therapy in the treatment of adolescents with polycystic ovary syndrome.

Journal of pediatric endocrinology & metabolism : JPEM 20050801

In vitro and in vivo evaluation of two extended release preparations of combination metformin and glipizide.

Drug development and industrial pharmacy 20050801

Comparison of peripheral metabolic effects of insulin and metformin following severe burn injury.

The Journal of trauma 20050801

Evaluation of efficacy and safety of fixed dose combination of glimepiride 2 mg pluspioglitazone 15 mg plus metformin SR 500 mg in the management of patients with type-2 diabetes mellitus.

Journal of the Indian Medical Association 20050801

Metformin monotherapy for type 2 diabetes mellitus.

The Cochrane database of systematic reviews 20050720

Serum anti-Müllerian hormone levels remain high until late reproductive age and decrease during metformin therapy in women with polycystic ovary syndrome.

Human reproduction (Oxford, England) 20050701

Prospective parallel randomized, double-blind, double-dummy controlled clinical trial comparing clomiphene citrate and metformin as the first-line treatment for ovulation induction in nonobese anovulatory women with polycystic ovary syndrome.

The Journal of clinical endocrinology and metabolism 20050701

Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase.

The Journal of biological chemistry 20050701

Ultra-short metformin pretreatment for clomiphene citrate-resistant polycystic ovary syndrome.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20050701

Effects of pentoxifylline on oxidative stress and levels of EGF and NO in blood of diabetic type-2 patients; a randomized, double-blind placebo-controlled clinical trial.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20050701

Metformin treatment of PCOS during adolescence and the reproductive period.

European journal of obstetrics, gynecology, and reproductive biology 20050701

The effect of metformin and rosiglitazone on postprandial lipid metabolism in obese insulin-resistant subjects.

Diabetes, obesity & metabolism 20050701

Design and evaluation of compound metformin/glipizide elementary osmotic pump tablets.

The Journal of pharmacy and pharmacology 20050701

Does metformin decrease blood pressure in patients with Type 2 diabetes intensively treated with insulin?

Diabetic medicine : a journal of the British Diabetic Association 20050701

Metformin prevents high-glucose-induced endothelial cell death through a mitochondrial permeability transition-dependent process.

Diabetes 20050701

Signaling pathways involved in human vascular smooth muscle cell proliferation and matrix metalloproteinase-2 expression induced by leptin: inhibitory effect of metformin.

Diabetes 20050701

Long-term treatment with rosiglitazone and metformin reduces the extent of, but does not prevent, islet amyloid deposition in mice expressing the gene for human islet amyloid polypeptide.

Diabetes 20050701

Insulin-sensitizing antihyperglycemic drugs and mortality after acute myocardial infarction: insights from the National Heart Care Project.

Diabetes care 20050701

Felodipine-influenced gingival enlargement in an uncontrolled type 2 diabetic patient.

Journal of periodontology 20050701

[HPLC determination of metformin hydrochloride-related substances].

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20050701

Metformin prevents the impairment of endothelium-dependent vascular relaxation induced by high glucose challenge in rabbit isolated perfused kidneys.

Naunyn-Schmiedeberg's archives of pharmacology 20050701

Regulation of SNARK activity in response to cellular stresses.

Biochimica et biophysica acta 20050620

[Medical management of primary nonalcoholic fatty liver disease].

Medicina clinica 20050618

Metformin and reduced risk of cancer in diabetic patients.

BMJ (Clinical research ed.) 20050604

[What dosage of antidiabetics?].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20050602

Severe metformin intoxication with lactic acidosis in an adolescent.

European journal of pediatrics 20050601

Neutrophil count in small-for-gestational age children: contrasting effects of metformin and growth hormone therapy.

The Journal of clinical endocrinology and metabolism 20050601

Administration of B-group vitamins reduces circulating homocysteine in polycystic ovarian syndrome patients treated with metformin: a randomized trial.

Human reproduction (Oxford, England) 20050601

Enhanced insulin-stimulated glycogen synthesis in response to insulin, metformin or rosiglitazone is associated with increased mRNA expression of GLUT4 and peroxisomal proliferator activator receptor gamma co-activator 1.

Diabetologia 20050601

Long-term efficacy and tolerability of add-on pioglitazone therapy to failing monotherapy compared with addition of gliclazide or metformin in patients with type 2 diabetes.

Diabetologia 20050601

Is metformin therapy for polycystic ovary syndrome safe during pregnancy?

Basic & clinical pharmacology & toxicology 20050601

Estimating live birth rates after ovulation induction in polycystic ovary syndrome: sample size calculations for the pregnancy in polycystic ovary syndrome trial.

Contemporary clinical trials 20050601

Efficacy and safety of hypoglycemic drugs in children with type 2 diabetes mellitus.

Pharmacotherapy 20050601

Secondary failure rates associated with metformin and sulfonylurea therapy for type 2 diabetes mellitus.

Pharmacotherapy 20050601

Metformin decreases intracellular production of reactive oxygen species in aortic endothelial cells.

Metabolism: clinical and experimental 20050601

Excretion of metformin into breast milk and the effect on nursing infants.

Obstetrics and gynecology 20050601

The 'worried-well', insulin resistance and metformin therapy.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 20050601

Insulin-sensitizers may protect against CHF.

Health news (Waltham, Mass.) 20050601

Metformin decelerates aging and development of mammary tumors in HER-2/neu transgenic mice.

Bulletin of experimental biology and medicine 20050601

[Insulin sensitizers in the treatment of polycystic ovary].

Ginecologia y obstetricia de Mexico 20050601

[Treatment experience with metformin in polycystic ovary syndrome].

Orvosi hetilap 20050522

Effectiveness and side effects of thiazolidinediones for type 2 diabetes.

The Medical journal of Australia 20050502

Pioglitazone improves insulin sensitivity through reduction in muscle lipid and redistribution of lipid into adipose tissue.

American journal of physiology. Endocrinology and metabolism 20050501

The importance of IRS-1 Gly972Arg polymorphism in evaluating the response to metformin treatment in polycystic ovary syndrome.

Human reproduction (Oxford, England) 20050501

Role of insulin secretagogues and insulin sensitizing agents in the prevention of cardiovascular disease in patients who have diabetes.

Cardiology clinics 20050501

A catalytic multi-pumping flow system for the chemiluminometric determination of metformin.

Analytical and bioanalytical chemistry 20050501

Therapeutic approaches to combating lipoatrophy: do they work?

The Journal of antimicrobial chemotherapy 20050501

Long term cardiovascular effects of oral antidiabetic agents in non-diabetic patients with insulin resistance: double blind, prospective, randomised study.

Heart (British Cardiac Society) 20050501

A randomized study of orlistat in combination with a weight management programme in obese patients with Type 2 diabetes treated with metformin.

Diabetic medicine : a journal of the British Diabetic Association 20050501

Continuing metformin when starting insulin in patients with Type 2 diabetes: a double-blind randomized placebo-controlled trial.

Diabetic medicine : a journal of the British Diabetic Association 20050501

Inhibition of dipeptidyl peptidase IV activity by oral metformin in Type 2 diabetes.

Diabetic medicine : a journal of the British Diabetic Association 20050501

Patients with Type 2 diabetes treated with metformin: prevalence of contraindications and their correlation with discontinuation.

Diabetic medicine : a journal of the British Diabetic Association 20050501

A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease.

The American journal of gastroenterology 20050501

Effects of metformin and rosiglitazone treatment on insulin signaling and glucose uptake in patients with newly diagnosed type 2 diabetes: a randomized controlled study.

Diabetes 20050501

Intensive lifestyle intervention or metformin on inflammation and coagulation in participants with impaired glucose tolerance.

Diabetes 20050501

Glycemic control continues to deteriorate after sulfonylureas are added to metformin among patients with type 2 diabetes.

Diabetes care 20050501

Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea.

Diabetes care 20050501

Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes.

Diabetes care 20050501

Effect on glycemic control of the addition of 2.5 mg glipizide GITS to metformin in patients with T2DM.

Diabetes research and clinical practice 20050501

Placental passage of metformin in women with polycystic ovary syndrome.

Fertility and sterility 20050501

Metformin administration improves endothelial function in women with polycystic ovary syndrome.

European journal of endocrinology 20050501

The fatty liver and insulin resistance.

Current molecular medicine 20050501

Antithrombotic effects of rosiglitazone-metformin versus glimepiride-metformin combination therapy in patients with type 2 diabetes mellitus and metabolic syndrome.

Pharmacotherapy 20050501

A site-specific controlled-release system for metformin.

The Journal of pharmacy and pharmacology 20050501

[Study on the effect of qinggan jiangtang tablet in improving the insulin resistance in patients with multiple metabolic syndrome].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20050501

Metformin: an advance in ovulation induction.

Irish medical journal 20050501

Efficacy of once- or twice-daily extended release metformin compared with thrice-daily immediate release metformin in type 2 diabetes mellitus.

The Journal of the Association of Physicians of India 20050501

[Use of oral lipid-lowering drugs in patients with type-2 diabetes mellitus].

Atencion primaria 20050430

[Therapy with oral antidiabetic agents -- special considerations in the case of coronary heart disease].

Deutsche medizinische Wochenschrift (1946) 20050429

[Controversial therapeutic strategies in the treatment of type 2 diabetes mellitus].

MMW Fortschritte der Medizin 20050428

Summaries for patients. The effect of diet and exercise or metformin on the metabolic syndrome.

Annals of internal medicine 20050419

The effect of metformin and intensive lifestyle intervention on the metabolic syndrome: the Diabetes Prevention Program randomized trial.

Annals of internal medicine 20050419

Homocysteine levels in women with polycystic ovary syndrome treated with metformin versus rosiglitazone: a randomized study.

Human reproduction (Oxford, England) 20050401

Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): implication of macrophages resident in the AT.

The Journal of clinical endocrinology and metabolism 20050401

What mediates the benefits associated with dipeptidyl peptidase-IV inhibition?

Diabetologia 20050401

Twice-daily pre-mixed insulin rather than basal insulin therapy alone results in better overall glycaemic control in patients with Type 2 diabetes.

Diabetic medicine : a journal of the British Diabetic Association 20050401

Reduced cardiovascular morbidity and mortality associated with metformin use in subjects with Type 2 diabetes.

Diabetic medicine : a journal of the British Diabetic Association 20050401

Impact of intensive lifestyle and metformin therapy on cardiovascular disease risk factors in the diabetes prevention program.

Diabetes care 20050401

Renal status among patients using metformin in a primary care setting.

Diabetes care 20050401

Metformin prevents glucose-induced protein kinase C-beta2 activation in human umbilical vein endothelial cells through an antioxidant mechanism.

Diabetes 20050401

Prevention of type 2 diabetes with troglitazone in the Diabetes Prevention Program.

Diabetes 20050401

A phase 2 clinical trial of metformin as a treatment for non-diabetic paediatric non-alcoholic steatohepatitis.

Alimentary pharmacology & therapeutics 20050401

[Metformin-induced cholestatic hepatitis].

Gastroenterologia y hepatologia 20050401

Effect of Sanguis draxonis (a Chinese traditional herb) on the formation of insulin resistance in rats.

Diabetes research and clinical practice 20050401

Does metformin modify ovarian responsiveness during exogenous FSH ovulation induction in normogonadotrophic anovulation? A placebo-controlled double-blind assessment.

European journal of endocrinology 20050401

[Perioperative treatment of patients with Diabetes mellitus].

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20050401

Research profile. Treating prediabetes. Exercise, metformin, or both? Barry Braun, PhD.

Diabetes forecast 20050401

Medicaid managed care: disparities in the use of thiazolidinediones compared with metformin.

Journal of the National Medical Association 20050401

Plasma homocysteine levels in patients with type 2 diabetes in a Mediterranean population: relation with nutritional and other factors.

Nutrition, metabolism, and cardiovascular diseases : NMCD 20050401

The management of type II diabetes.

SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging 20050401

The development and validation of liquid chromatography method for the simultaneous determination of metformin and glipizide, gliclazide, glibenclamide or glimperide in plasma.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050325

Polycystic ovary syndrome.

The New England journal of medicine 20050324

[Cardiovascular risk to be considered. Proinsulin test for stage-adjusted therapy].

MMW Fortschritte der Medizin 20050310

Responses of serum androgen and insulin resistance to metformin and pioglitazone in obese, insulin-resistant women with polycystic ovary syndrome.

The Journal of clinical endocrinology and metabolism 20050301

Unexpected recovery from prolonged hypoglycemic coma: a protective role of metformin?

Intensive care medicine 20050301

Haematocrit, type 2 diabetes, and endothelium-dependent vasodilatation of resistance vessels.

European heart journal 20050301

Metformin-induced suppression of glucose-6-phosphatase expression is independent of insulin signaling in rat hepatoma cells.

International journal of molecular medicine 20050301

Comparison of pioglitazone with other antidiabetic drugs for associated incidence of liver failure: no evidence of increased risk of liver failure with pioglitazone.

Diabetes, obesity & metabolism 20050301

Effects of metformin on the body composition in subjects with risk factors for type 2 diabetes.

Diabetes, obesity & metabolism 20050301

Improvement of glycaemic control with rebound following orlistat initiation and cessation associated with minimal weight change.

Diabetic medicine : a journal of the British Diabetic Association 20050301

Low-dose metformin improves hyperglycaemia related to myotonic dystrophy.

Diabetic medicine : a journal of the British Diabetic Association 20050301

Comparative outcomes study of metformin intervention versus conventional approach the COSMIC Approach Study.

Diabetes care 20050301

The effects of rosiglitazone and metformin on the plasma concentrations of resistin in patients with type 2 diabetes mellitus.

Metabolism: clinical and experimental 20050301

Summaries for patients. The cost-effectiveness of strategies to prevent type 2 diabetes.

Annals of internal medicine 20050301

The cost-effectiveness of lifestyle modification or metformin in preventing type 2 diabetes in adults with impaired glucose tolerance.

Annals of internal medicine 20050301

Antihyperglycemics during the perioperative period.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20050301

Intensive care treatment of severe mixed metabolic acidosis.

Acta anaesthesiologica Scandinavica 20050301

Glycemic management of type 2 diabetes: an emerging strategy with oral agents, insulins, and combinations.

Endocrinology and metabolism clinics of North America 20050301

Insulin monotherapy vs. combination therapy.

American family physician 20050301

Polycystic ovary syndrome--a management update.

Australian family physician 20050301

Effect of N-benzoyl-D-phenylalanine on streptozotocin-induced changes in the lipid and lipoprotein profile in rats.

The Journal of pharmacy and pharmacology 20050301

Diabetes in the new General Medical Services contract: targets and adherence to metformin therapy.

International journal of clinical practice 20050301

Protective effects of metformin treatment on the liver injury of streptozotocin-diabetic rats.

Human & experimental toxicology 20050301

[Specific aspects of diabetes management in the elderly].

MMW Fortschritte der Medizin 20050217

Diabetes mellitus in a domesticated Spanish mustang.

Journal of the American Veterinary Medical Association 20050215

Thiazolidinediones, metformin, and outcomes in older patients with diabetes and heart failure: an observational study.

Circulation 20050208

[Nothing here follows protocol F. Elderly diabetic patients are not 'DMP qualified'].

MMW Fortschritte der Medizin 20050203

Orlistat is as beneficial as metformin in the treatment of polycystic ovarian syndrome.

The Journal of clinical endocrinology and metabolism 20050201

Determinants of subclinical diabetic heart disease.

Diabetologia 20050201

Influence of metformin on glucose intolerance and muscle catabolism following severe burn injury.

Annals of surgery 20050201

Combined use of metformin and ethinyl estradiol-cyproterone acetate in polycystic ovary syndrome.

European journal of obstetrics, gynecology, and reproductive biology 20050201

Regarding the use of HOMA to aid drug selection.

Diabetic medicine : a journal of the British Diabetic Association 20050201

Educational intervention: a tool for decreasing medication errors.

International journal for quality in health care : journal of the International Society for Quality in Health Care 20050201

Comparison of basal insulin added to oral agents versus twice-daily premixed insulin as initial insulin therapy for type 2 diabetes.

Diabetes care 20050201

Initiating insulin therapy in type 2 Diabetes: a comparison of biphasic and basal insulin analogs.

Diabetes care 20050201

Comparison of effect of pioglitazone with metformin or sulfonylurea (monotherapy and combination therapy) on postload glycemia and composite insulin sensitivity index during an oral glucose tolerance test in patients with type 2 diabetes.

Diabetes care 20050201

Clinical inquiries. Do insulin-sensitizing drugs increase ovulation rates for women with PCOS?

The Journal of family practice 20050201

Differential regulation of insulin action and tumor necrosis factor alpha system activity by metformin.

Metabolism: clinical and experimental 20050201

[Study on therapeutic effects of metformin on rat fatty livers induced by high fat feeding].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20050201

[Drug therapy for nonalcoholic fatty liver disease].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20050201

Which oral drug is right for your type 2 diabetes? New thinking on oral drug combinations that can provide better glycemic control.

Health news (Waltham, Mass.) 20050201

Effects of metformin and ethinyl estradiol-cyproterone acetate on lipid levels in obese and non-obese women with polycystic ovary syndrome.

European journal of endocrinology 20050201

Thiazolidinediones for treatment of polycystic ovary syndrome.

Pharmacotherapy 20050201

The effect of short-term glycemic regulation with gliclazide and metformin on postprandial lipemia.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20050201

[Pathophysiological conditions progressing from impaired glucose tolerance: type 2 diabetes mellitus].

Nihon rinsho. Japanese journal of clinical medicine 20050201

[Characteristic of metformin for treatment of impaired glucose tolerance].

Nihon rinsho. Japanese journal of clinical medicine 20050201

[Diabetes prevention program (metformin)].

Nihon rinsho. Japanese journal of clinical medicine 20050201

[Diet therapy for impaired glucose tolerance].

Nihon rinsho. Japanese journal of clinical medicine 20050201

[Therapies for newly-onset diabetic patients].

Nihon rinsho. Japanese journal of clinical medicine 20050201

[Treatment for coronary artery disease patients with impaired glucose tolerance].

Nihon rinsho. Japanese journal of clinical medicine 20050201

Metformin transport by renal basolateral organic cation transporter hOCT2.

Pharmaceutical research 20050201

Use of metformin in pregnancies with diabetes: a case series from India.

The Journal of the Association of Physicians of India 20050201

Pioglitazone in a subgroup of patients with type 2 diabetes meeting the criteria for metabolic syndrome.

International journal of clinical practice 20050201

[DIGAMI 2: breaking the spell of insulin for heart infarct. Re the article in DMW 45/2004].

Deutsche medizinische Wochenschrift (1946) 20050128

Development and validation for high selective quantitative determination of metformin in human plasma by cation exchanging with normal-phase LC/MS/MS.

Journal of pharmaceutical and biomedical analysis 20050104

Long-term therapy with addition of pioglitazone to metformin compared with the addition of gliclazide to metformin in patients with type 2 diabetes: a randomized, comparative study.

Diabetes/metabolism research and reviews 20050101

Flutamide-metformin plus ethinylestradiol-drospirenone for lipolysis and antiatherogenesis in young women with ovarian hyperandrogenism: the key role of metformin at the start and after more than one year of therapy.

The Journal of clinical endocrinology and metabolism 20050101

Comparison of the effects of acarbose and metformin use on ovulation rates in clomiphene citrate-resistant polycystic ovary syndrome.

Human reproduction (Oxford, England) 20050101

Pharmacologic prevention or delay of type 2 diabetes mellitus.

The Annals of pharmacotherapy 20050101

Metformin-diet benefits in women with polycystic ovary syndrome in the bottom and top quintiles for insulin resistance.

Metabolism: clinical and experimental 20050101

Effect of N-benzoyl-D-phenylalanine and metformin on carbohydrate metabolic enzymes in neonatal streptozotocin diabetic rats.

Clinica chimica acta; international journal of clinical chemistry 20050101

The effect of combination therapy with metformin and combined oral contraceptives (COC) versus COC alone on insulin sensitivity, hyperandrogenaemia, SHBG and lipids in PCOS patients.

Human reproduction (Oxford, England) 20050101

Effects of short-term treatment with metformin on markers of endothelial function and inflammatory activity in type 2 diabetes mellitus: a randomized, placebo-controlled trial.

Journal of internal medicine 20050101

Antidiabetic drugs and heart failure risk in patients with type 2 diabetes in the U.K. primary care setting.

Diabetes care 20050101

Islet adaptation to insulin resistance: mechanisms and implications for intervention.

Diabetes, obesity & metabolism 20050101

Efficacy, dose-response relationship and safety of once-daily extended-release metformin (Glucophage XR) in type 2 diabetic patients with inadequate glycaemic control despite prior treatment with diet and exercise: results from two double-blind, placebo-controlled studies.

Diabetes, obesity & metabolism 20050101

Insulin sensitizing drugs increase the endogenous dopaminergic tone in obese insulin-resistant women with polycystic ovary syndrome.

The Journal of endocrinology 20050101

Metformin reduces serum mullerian-inhibiting substance levels in women with polycystic ovary syndrome after protracted treatment.

Fertility and sterility 20050101

Metabolic syndrome: evaluation of pathological and therapeutic outcomes.

American heart journal 20050101

Insulin sensitizers: past, present and future.

Mymensingh medical journal : MMJ 20050101

Effects of a combination of rhGH and metformin on adiponectin levels in patients with metabolic syndrome.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20050101

Metformin monotherapy in lean women with polycystic ovary syndrome.

Reproductive biomedicine online 20050101

[Clinicogenetic aspects of carbohydrate metabolism disorders and efficacy of their correction with moxonidine and metformine in patients with arterial hypertension].

Terapevticheskii arkhiv 20050101

Trends in the prevalence and management of diagnosed type 2 diabetes 1994-2001 in England and Wales.

BMC family practice 20050101

AMPK activation as a strategy for reversing the endothelial lipotoxicity underlying the increased vascular risk associated with insulin resistance syndrome.

Medical hypotheses 20050101

Effect of pioglitazone on metabolic syndrome risk factors: results of double-blind, multicenter, randomized clinical trials.

Current medical research and opinion 20050101

Long-term effect of glimepiride and rosiglitazone on non-conventional cardiovascular risk factors in metformin-treated patients affected by metabolic syndrome: a randomized, double-blind clinical trial.

The Journal of international medical research 20050101

Steady-state pharmacokinetics of a novel extended-release metformin formulation.

Clinical pharmacokinetics 20050101

[Metformin for the treatment of polycystic ovary syndrome].

Akusherstvo i ginekologiia 20050101

Rosiglitazone/Metformin.

Drugs 20050101

[Insulin sensitizers].

Revue medicale de Liege 20050101

[Towards a tripple oral therapy in the pharmacological treatment of type 2 diabetes?].

Revue medicale de Liege 20050101

Exenatide.

Drugs 20050101

Presentation of polycystic ovary syndrome and its management with clomiphene alone and in combination with metformin.

Journal of Ayub Medical College, Abbottabad : JAMC 20050101

Effects of metformin combined with cyproterone acetate on clinical features, endocrine and metabolism of non-obese women with polycystic ovarian syndrome.

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20050101

Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice.

Experimental gerontology 20050101

Metformin extended release: metformin gastric retention, metformin GR, metformin XR.

Drugs in R&D 20050101

Effect of N-benzoyl-D-phenylalanine, a new potential oral antidiabetic agent, in neonatal streptozotocin-induced diabetes in rats.

Pharmacological reports : PR 20050101

Manufacturing violations prompt seizure of Paxil CR, Avandamet.

FDA consumer 20050101

Metformin in the treatment of clomiphene citrate-resistant women with high BMI and primary infertility: clinical results and reproductive outcome.

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 20050101

Estimation of pioglitazone hydrochloride and metformin hydrochloride in tablets by derivative spectrophotometry and liquid chromatographic methods.

Journal of AOAC International 20050101

Metformin lactic acidosis and anaesthesia: myth or reality?

Acta anaesthesiologica Belgica 20050101

Polycystic ovary syndrome (PCOS) in the adolescent patient: recommendations for practice.

Pediatric nursing 20050101

Willingness to pay for inhaled insulin: a contingent valuation approach.

PharmacoEconomics 20050101

[Molecular action of insulin-sensitizing agents].

Endokrynologia Polska 20050101

[Follow-up of the use of metformin among the high risk population].

Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20050101

Diabetes associated with atypical antipsychotic treatment may be severe but reversible: case report.

International journal of psychiatry in medicine 20050101

[Use of metformin (siofor) in patients with gout and insulin resistance (pilot 6-month results)].

Terapevticheskii arkhiv 20050101

Role of metformin in correcting hyperinsulinemia, menstrual irregularity and anovulation in polycystic ovary syndrome.

Journal of Ayub Medical College, Abbottabad : JAMC 20050101

Response to diet and metformin in women with idiopathic intracranial hypertension with and without concurrent polycystic ovary syndrome or hyperinsulinemia.

MedGenMed : Medscape general medicine 20050101

Case 25-2004: a woman with severe obesity, diabetes, and hypertension.

The New England journal of medicine 20041223

[Rosiglitazone-metformin fixed dose combination for treatment of type 2 diabetes].

Presse medicale (Paris, France : 1983) 20041218

Women with polycystic ovary syndrome (PCOS) often undergo protracted treatment with metformin and are disinclined to stop: indications for a change in licensing arrangements?

Human reproduction (Oxford, England) 20041201

Effect of metformin vs. placebo treatment on serum fatty acids in non-diabetic obese insulin resistant individuals.

Prostaglandins, leukotrienes, and essential fatty acids 20041201

Metformin in polycystic ovary syndrome.

Current opinion in obstetrics & gynecology 20041201

[Oral diabetes treatment. Which substance is indicated at which time?].

Der Internist 20041201

Augmented metabolic control improves myocardial diastolic function and perfusion in patients with non-insulin dependent diabetes.

Heart (British Cardiac Society) 20041201

Metformin therapy in women with polycystic ovary syndrome.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20041201

Non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD/NASH): treatment.

Best practice & research. Clinical gastroenterology 20041201

Metformin prevents the development of acute lipid-induced insulin resistance in the rat through altered hepatic signaling mechanisms.

Diabetes 20041201

Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes.

Diabetes care 20041201

Real world effectiveness of rosiglitazone added to maximal (tolerated) doses of metformin and a sulphonylurea agent: response to Roy et al.

Diabetes care 20041201

Alpha-lipoic acid, an anti-obesity agent?

Expert opinion on investigational drugs 20041201

Enhancement of insulin-stimulated myocardial glucose uptake in patients with Type 2 diabetes treated with rosiglitazone.

Diabetic medicine : a journal of the British Diabetic Association 20041201

Efficacy and safety of pioglitazone versus metformin in patients with type 2 diabetes mellitus: a double-blind, randomized trial.

The Journal of clinical endocrinology and metabolism 20041201

Retrobulbar injection of methylprednisolone in diffuse diabetic macular edema.

Retina (Philadelphia, Pa.) 20041201

Link between metformin and lactic acidosis?

American family physician 20041201

Radical-induced oxidation of metformin.

European journal of biochemistry 20041201

Association of diabetes mellitus and glycemic control strategies with clinical outcomes after acute coronary syndromes.

American heart journal 20041201

Addition of rosiglitazone to glimepirid and metformin combination therapy in type 2 diabetes.

Endocrine journal 20041201

Initiating oral glucose-lowering therapy with metformin in type 2 diabetic patients: an evidence-based strategy to reduce the burden of late-developing diabetes complications.

Diabetes & metabolism 20041201

Combined therapy with insulin lispro Mix 75/25 plus metformin or insulin glargine plus metformin: a 16-week, randomized, open-label, crossover study in patients with type 2 diabetes beginning insulin therapy.

Clinical therapeutics 20041201

Adherence to a fixed-dose combination of rosiglitazone maleate/metformin hydrochloride in subjects with type 2 diabetes mellitus: a retrospective database analysis.

Clinical therapeutics 20041201

Test and teach. Number Fifty-three. Diagnosis: Diabetes-related dyslipidaemia.

Pathology 20041201

Polycystic ovary syndrome.

Clinical evidence 20041201

Effects of metformin on glucagon-like peptide-1 levels in obese patients with and without Type 2 diabetes.

Diabetes, nutrition & metabolism 20041201

Effects of two different glibenclamide dose-strengths in the fixed combination with metformin in patients with poorly controlled T2DM: a double blind, prospective, randomised, cross-over clinical trial.

Diabetes, nutrition & metabolism 20041201

[Effects of glimepiride and metformin on free fatty acid in patients with Type 2 diabetes mellitus].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20041201

AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells.

The Journal of biological chemistry 20041112

Reduced serum dipeptidyl peptidase-IV after metformin and pioglitazone treatments.

Biochemical and biophysical research communications 20041105

Insulin-sensitizing agents as primary therapy for patients with polycystic ovarian syndrome.

Human reproduction (Oxford, England) 20041101

Are laparoscopic ovarian diathermy and gonadotropin administration the only therapeutic second-steps in clomiphene-citrate resistant women with polycystic ovary syndrome?

Human reproduction (Oxford, England) 20041101

Pre-prandial vs. post-prandial capillary glucose measurements as targets for repaglinide dose titration in people with diet-treated or metformin-treated Type 2 diabetes: a randomized controlled clinical trial.

Diabetic medicine : a journal of the British Diabetic Association 20041101

Economic evaluation of therapeutic interventions to prevent Type 2 diabetes in Canada.

Diabetic medicine : a journal of the British Diabetic Association 20041101

Impact of metformin on glucose metabolism in nondiabetic, obese African Americans: a placebo-controlled, 24-month randomized study.

Diabetes care 20041101

Effects of metformin treatment on luteal phase progesterone concentration in polycystic ovary syndrome.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20041101

Metformin in type 2 diabetes.

The Journal of family practice 20041101

Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin.

The Journal of clinical endocrinology and metabolism 20041101

Metformin inhibits leptin secretion via a mitogen-activated protein kinase signalling pathway in brown adipocytes.

The Journal of endocrinology 20041101

Adiponectin and C-reactive protein in obesity, type 2 diabetes, and monodrug therapy.

Metabolism: clinical and experimental 20041101

Does metformin induce ovulation in normoandrogenic anovulatory women?

American journal of obstetrics and gynecology 20041101

Metformin or gliclazide, rather than glibenclamide, attenuate progression of carotid intima-media thickness in subjects with type 2 diabetes.

Diabetologia 20041101

Dysregulation of growth hormone in acquired generalized lipodystrophy.

Saudi medical journal 20041101

Dietary intake in the diabetes prevention program cohort: baseline and 1-year post randomization.

Annals of epidemiology 20041101

Hepatotoxicity of drugs used for treatment of obesity and its comorbidities.

Seminars in liver disease 20041101

A lesson in early morning hyperglycemia.

The Nurse practitioner 20041101

Redefining insulin therapy in type 2 diabetes mellitus.

Postgraduate medicine 20041101

Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species.

The Journal of biological chemistry 20041015

Dupuytren's disease risk factors.

Journal of hand surgery (Edinburgh, Scotland) 20041001

Metformin--current restrictions should be alleviated.

Journal of internal medicine 20041001

The combination oral and nutritional treatment of late-onset diabetes mellitus (CONTROL DM) trial results.

Diabetic medicine : a journal of the British Diabetic Association 20041001

Two N,N-dimethylbiguanidium salts displaying double hydrogen bonds to the counter-ions.

Acta crystallographica. Section C, Crystal structure communications 20041001

Editorial: Metformin--comparison with other therapies in ovulation induction in polycystic ovary syndrome.

The Journal of clinical endocrinology and metabolism 20041001

Metformin administration versus laparoscopic ovarian diathermy in clomiphene citrate-resistant women with polycystic ovary syndrome: a prospective parallel randomized double-blind placebo-controlled trial.

The Journal of clinical endocrinology and metabolism 20041001

Increased plasma concentration of macrophage migration inhibitory factor (MIF) and MIF mRNA in mononuclear cells in the obese and the suppressive action of metformin.

The Journal of clinical endocrinology and metabolism 20041001

Do risk factors for lactic acidosis influence dosing of metformin?

Journal of clinical pharmacy and therapeutics 20041001

Effects of metformin and rosiglitazone, alone and in combination, in nonobese women with polycystic ovary syndrome and normal indices of insulin sensitivity.

Fertility and sterility 20041001

Pregnancy loss, polycystic ovary syndrome, thrombophilia, hypofibrinolysis, enoxaparin, metformin.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20041001

Effects of pioglitazone on the components of diabetic dyslipidaemia: results of double-blind, multicentre, randomised studies.

International journal of clinical practice 20041001

Efficacy of metformin on ovulation induction in Asian women with polycystic ovary syndrome.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20041001

[Therapy objectives and daily practice--to which extent are blood sugar target values accessible in daily practice?].

Praxis 20040929

[Assessment of the management of type 2 diabetes].

Presse medicale (Paris, France : 1983) 20040925

Metformin inhibits mitochondrial permeability transition and cell death: a pharmacological in vitro study.

The Biochemical journal 20040915

Rapid and sensitive liquid chromatography-tandem mass spectrometric method for the quantitation of metformin in human plasma.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040905

Erythema multiforme from metformin.

The Annals of pharmacotherapy 20040901

Nateglinide alone or with metformin safely improves glycaemia to target in patients up to an age of 84.

Diabetes, obesity & metabolism 20040901

Outcomes of initiation of therapy with once-daily combination of a thiazolidinedione and a biguanide at an early stage of type 2 diabetes.

Diabetes, obesity & metabolism 20040901

Effect of Pancreas Tonic (an ayurvedic herbal supplement) in type 2 diabetes mellitus.

Metabolism: clinical and experimental 20040901

Pharmacokinetics and dose proportionality of extended-release metformin following administration of 1000, 1500, 2000 and 2500 mg in healthy volunteers.

Biopharmaceutics & drug disposition 20040901

Insulin sensitization for girls with precocious pubarche and with risk for polycystic ovary syndrome: effects of prepubertal initiation and postpubertal discontinuation of metformin treatment.

The Journal of clinical endocrinology and metabolism 20040901

Flutamide-metformin plus ethinylestradiol-drospirenone for lipolysis and antiatherogenesis in young women with ovarian hyperandrogenism: the key role of early, low-dose flutamide.

The Journal of clinical endocrinology and metabolism 20040901

Nonadherence as a predictor of antidiabetic drug therapy intensification (augmentation).

Pharmacoepidemiology and drug safety 20040901

Metformin ameliorates treatment of obese type 2 diabetic patients with mental retardation; its effects on eating behavior and serum leptin levels.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20040901

[Current concept of polycystic ovary syndrome].

Zhonghua fu chan ke za zhi 20040901

[Clinical study on treating insulin resistance and promoting ovulation in polycystic ovary syndrome].

Zhonghua fu chan ke za zhi 20040901

Glycemic control with metformin or insulin therapy in adolescents with type 2 diabetes mellitus.

Journal of pediatric endocrinology & metabolism : JPEM 20040901

Durable efficacy of metformin/glibenclamide combination tablets (Glucovance) during 52 weeks of open-label treatment in type 2 diabetic patients with hyperglycaemia despite previous sulphonylurea monotherapy.

International journal of clinical practice 20040901

Cardiovascular effects of treatment of type 2 diabetes with pioglitazone, metformin and gliclazide.

International journal of clinical practice 20040901

Avandamet: combined metformin-rosiglitazone treatment for insulin resistance in type 2 diabetes.

International journal of clinical practice 20040901

Is ovulation induction still a therapeutic problem in patients with polycystic ovary syndrome?

Journal of endocrinological investigation 20040901

Metformin versus flutamide in the treatment of metabolic consequences of non-obese young women with polycystic ovary syndrome: a randomized prospective study.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20040901

Increased insulin-like growth factor-I levels in women with polycystic ovary syndrome, and beneficial effects of metformin therapy.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20040901

Fatty acid composition of erythrocyte phospholipids is related to insulin levels, secretion and resistance in obese type 2 diabetics on Metformin.

Clinica chimica acta; international journal of clinical chemistry 20040816

Insulin resistance and metformin in polycystic ovary syndrome.

European journal of obstetrics, gynecology, and reproductive biology 20040810

[Progress in diagnosis of and therapy for diabetic lactic acidosis].

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20040810

Metformin therapy and diabetes in pregnancy.

The Medical journal of Australia 20040802

Metformin causes reduction of food intake and body weight gain and improvement of glucose intolerance in combination with dipeptidyl peptidase IV inhibitor in Zucker fa/fa rats.

The Journal of pharmacology and experimental therapeutics 20040801

Metformin reduces pregnancy complications without affecting androgen levels in pregnant polycystic ovary syndrome women: results of a randomized study.

Human reproduction (Oxford, England) 20040801

Endothelial dysfunction, inflammation and diabetes.

Reviews in endocrine & metabolic disorders 20040801

Comparison of the effect of orlistat vs orlistat plus metformin on weight loss and insulin resistance in obese women.

International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 20040801

Flutamide-metformin plus an oral contraceptive (OC) for young women with polycystic ovary syndrome: switch from third- to fourth-generation OC reduces body adiposity.

Human reproduction (Oxford, England) 20040801

Laparoscopic treatment of polycystic ovaries: is its place diminishing?

Current opinion in obstetrics & gynecology 20040801

Metformin-induced stimulation of AMP-activated protein kinase in beta-cells impairs their glucose responsiveness and can lead to apoptosis.

Biochemical pharmacology 20040801

Combination of intermittent haemodialysis and high-volume continuous haemofiltration for the treatment of severe metformin-induced lactic acidosis.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20040801

Metformin, pre-eclampsia, and pregnancy outcomes in women with polycystic ovary syndrome.

Diabetic medicine : a journal of the British Diabetic Association 20040801

Effects of rosiglitazone and metformin on liver fat content, hepatic insulin resistance, insulin clearance, and gene expression in adipose tissue in patients with type 2 diabetes.

Diabetes 20040801

The differential effects of metformin on markers of endothelial activation and inflammation in subjects with impaired glucose tolerance: a placebo-controlled, randomized clinical trial.

The Journal of clinical endocrinology and metabolism 20040801

A randomized, 48-week, placebo-controlled trial of intensive lifestyle modification and/or metformin therapy in overweight women with polycystic ovary syndrome: a pilot study.

Fertility and sterility 20040801

Treatment of polycystic ovary syndrome in adolescents.

American family physician 20040801

Comparing the long-term cost-effectiveness of repaglinide plus metformin versus nateglinide plus metformin in type 2 diabetes patients with inadequate glycaemic control: an application of the CORE Diabetes Model in type 2 diabetes.

Current medical research and opinion 20040801

Liquid chromatographic/electrospray ionization mass spectrometric identification of the oxidation end-products of metformin in aqueous solutions.

Journal of mass spectrometry : JMS 20040801

Nonalcoholic fatty liver disease in the pediatric population.

Clinics in liver disease 20040801

Metformin monitoring and change in serum creatinine levels in patients undergoing radiologic procedures involving administration of intravenous contrast media.

Pharmacotherapy 20040801

Monitoring safety and effectiveness in patients receiving metformin.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20040801

Effect of metformin on the clinical and metabolic assessment of women with polycystic ovary syndrome.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20040801

Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte.

The Journal of biological chemistry 20040730

[2-year data of large clinical comparative studies. Type 2 diabetes: lasting metabolic control with pioglitazone].

MMW Fortschritte der Medizin 20040722

Metformin and serious adverse effects.

The Medical journal of Australia 20040705

Pharmacodynamic-pharmacokinetic profiles of metformin hydrochloride from a mucoadhesive formulation of a polysaccharide with antidiabetic property in streptozotocin-induced diabetic rat models.

Biomaterials 20040701

The effect of metformin on blood pressure, plasma cholesterol and triglycerides in type 2 diabetes mellitus: a systematic review.

Journal of internal medicine 20040701

Biowaiver extension potential to BCS Class III high solubility-low permeability drugs: bridging evidence for metformin immediate-release tablet.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20040701

Improved glycemic control without weight gain using triple therapy in type 2 diabetes.

Diabetes care 20040701

Real world effectiveness of rosiglitazone added to maximal (tolerated) doses of metformin and a sulfonylurea agent: a systematic evaluation of triple oral therapy in a minority population.

Diabetes care 20040701

The phantom of lactic acidosis due to metformin in patients with diabetes.

Diabetes care 20040701

The combined effect of triple therapy with rosiglitazone, metformin, and insulin aspart in type 2 diabetic patients: response to Poulsen et al.

Diabetes care 20040701

Twice-Daily NPH or mixture insulins versus triple therapy: apples versus oranges: response to Poulsen et al.

Diabetes care 20040701

Metformin in the treatment of non-alcoholic steatohepatitis: a pilot open label trial.

Alimentary pharmacology & therapeutics 20040701

Review of nonsurgical and surgical treatment and the role of insulin-sensitizing agents in the management of infertile women with polycystic ovary syndrome.

Acta obstetricia et gynecologica Scandinavica 20040701

Evidence based medicine, guidelines and common sense.

Age and ageing 20040701

Direct demonstration of lipid sequestration as a mechanism by which rosiglitazone prevents fatty-acid-induced insulin resistance in the rat: comparison with metformin.

Diabetologia 20040701

Enhancement of early- and late-phase insulin secretion and insulin sensitivity by the combination of repaglinide and metformin in type 2 diabetes mellitus.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20040701

Why hold the metformin?

Nursing 20040701

Surgical treatment of polycystic ovary syndrome associated with infertility.

Reproductive biomedicine online 20040701

Pharmacokinetic-pharmacodynamic modeling for the relationship between glucose-lowering effect and plasma concentration of metformin in volunteers.

Archives of pharmacal research 20040701

Rosiglitazone maleate/metformin hydrochloride: a new formulation therapy for type 2 diabetes.

Drugs of today (Barcelona, Spain : 1998) 20040701

Effect of metformin on plasma homocysteine, vitamin B12 and folic acid: a cross-sectional study in patients with type 2 diabetes mellitus.

Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20040701

Revisit of metformin treatment in polycystic ovarian syndrome.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20040701

Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion.

American journal of physiology. Endocrinology and metabolism 20040601

Increased adipose tissue expression of Grb14 in several models of insulin resistance.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040601

Height, weight, and motor-social development during the first 18 months of life in 126 infants born to 109 mothers with polycystic ovary syndrome who conceived on and continued metformin through pregnancy.

Human reproduction (Oxford, England) 20040601

Metformin treatment before IVF/ICSI in women with polycystic ovary syndrome; a prospective, randomized, double blind study.

Human reproduction (Oxford, England) 20040601

Glibenclamide-induced acute haemolytic anaemia revealing a G6PD-deficiency.

Diabetes research and clinical practice 20040601

Metformin attenuates progression of carotid arterial wall thickness in patients with type 2 diabetes.

Diabetes research and clinical practice 20040601

Should we continue or stop insulin sensitizing drugs during pregnancy?

Current opinion in obstetrics & gynecology 20040601

Metformin (Glucophage) inhibits tyrosine phosphatase activity to stimulate the insulin receptor tyrosine kinase.

Biochemical pharmacology 20040601

Hyperandrogenism and the skin.

Journal of the American Academy of Dermatology 20040601

Understanding the rising incidence of type 2 diabetes in adolescence.

Archives of disease in childhood 20040601

Vascular effects of improving metabolic control with metformin or rosiglitazone in type 2 diabetes.

Diabetes care 20040601

Rosiglitazone plus metformin: combination therapy for Type 2 diabetes.

Expert opinion on pharmacotherapy 20040601

Relation of metformin treatment to clinical events in diabetic patients undergoing percutaneous intervention.

The American journal of cardiology 20040601

Comparison of efficacy of spironolactone with metformin in the management of polycystic ovary syndrome: an open-labeled study.

The Journal of clinical endocrinology and metabolism 20040601

Efficacy and tolerability of initial combination therapy with nateglinide and metformin in treatment-naïve patients with type 2 diabetes.

Current medical research and opinion 20040601

[Primary prevention of diabetes mellitus type 2].

Der Internist 20040601

Development of calorie restriction mimetics as a prolongevity strategy.

Annals of the New York Academy of Sciences 20040601

Splanchnic haemodynamics in non-alcoholic fatty liver disease: effect of a dietary/pharmacological treatment. A pilot study.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20040601

Lipoatrophic diabetes in an elderly woman: clinical course and serum adipocytokine concentrations.

Endocrine journal 20040601

A comparison of the effects of thiazolidinediones and metformin on metabolic control in patients with type 2 diabetes mellitus.

Clinical therapeutics 20040601

[Lactic acidosis in diabetic patient treated with metformin].

Anales de medicina interna (Madrid, Spain : 1984) 20040601

Metabolic variations with oral antidiabetic drugs in patients with Type 2 diabetes: comparison between glimepiride and metformin.

Diabetes, nutrition & metabolism 20040601

Use of glimepiride and insulin sensitizers in the treatment of type 2 diabetes--a study in Indians.

The Journal of the Association of Physicians of India 20040601

Effect of potassium chloride and cationic drug on swelling, erosion and release from kappa-carrageenan matrices.

AAPS PharmSciTech 20040601

[Metformin, an efficacious drug in the treatment of polycystic ovary syndrome].

Deutsche medizinische Wochenschrift (1946) 20040507

Metformin therapy and diabetes in pregnancy.

The Medical journal of Australia 20040503

Polycystic ovary syndrome in adolescence--a therapeutic conundrum.

Human reproduction (Oxford, England) 20040501

Toxic effects from metformin exposure.

The Annals of pharmacotherapy 20040501

Screening for and treatment of polycystic ovary syndrome in teenagers.

Experimental biology and medicine (Maywood, N.J.) 20040501

Glycemic treatment: Control of glycemia.

Diabetes care 20040501

Starting insulin in type 2 diabetes: continue oral hypoglycemic agents? A randomized trial in primary care.

The Journal of family practice 20040501

Differential effects of metformin and exercise on muscle adiposity and metabolic indices in human immunodeficiency virus-infected patients.

The Journal of clinical endocrinology and metabolism 20040501

Pioglitazone as monotherapy or in combination with sulfonylurea or metformin enhances insulin sensitivity (HOMA-S or QUICKI) in patients with type 2 diabetes.

Current medical research and opinion 20040501

Systematic review of the long-term effects and economic consequences of treatments for obesity and implications for health improvement.

Health technology assessment (Winchester, England) 20040501

Medical treatment regimens of hirsutism.

Reproductive biomedicine online 20040501

By the way, doctor. I'm a 63-year-old woman with impaired fasting glucose, and I'd like to take Glucophage or Avandia to prevent or delay the onset of diabetes. My weight was well controlled until my 50s, when it started to rise. I think impaired fasting glucose caused the weight gain.

Harvard health letter 20040501

A validated HPLC method with ultraviolet detection for the determination of buformin in plasma.

Biomedical chromatography : BMC 20040501

Effects of metformin on clinical and biochemical parameters in polycystic ovary syndrome.

The Journal of reproductive medicine 20040501

[Cost-effective analysis of preventive treatment on diabetes].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 20040501

Which treatment options should be used in adolescents with polycystic ovary syndrome?

Journal of pediatric endocrinology & metabolism : JPEM 20040501

[Diabetes mellitus, oxidative stress and advanced glycation endproducts].

Annales pharmaceutiques francaises 20040501

Assessment of quality control parameters and interchangeability of multisourced metformin HCl tablets marketed in Nigeria.

Bollettino chimico farmaceutico 20040501

Pioglitazone plus a sulphonylurea or metformin is associated with increased lipoprotein particle size in patients with type 2 diabetes.

Diabetes & vascular disease research 20040501

[Diabetes update: preventing type 2 diabetes. Individualized stepwise therapy (oral antidiabetic agents). Multifactorial intervention].

Praxis 20040428

Treatment of insulin resistance in diabetes mellitus.

European journal of pharmacology 20040419

Metformin therapy increases insulin-like growth factor binding protein-1 in hyperinsulinemic women with polycystic ovary syndrome.

European journal of obstetrics, gynecology, and reproductive biology 20040415

The effects of metformin on insulin resistance, clomiphene-induced ovulation and pregnancy rates in women with polycystic ovary syndrome.

European journal of obstetrics, gynecology, and reproductive biology 20040415

Impaired glucose tolerance and impaired fasting glucose.

American family physician 20040415

Rapid determination of metformin in human plasma by liquid chromatography-tandem mass spectrometry method.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040405

Electronic monitoring and counseling to improve medication adherence.

Behaviour research and therapy 20040401

Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions?

Diabetes 20040401

Ethinylestradiol-drospirenone, flutamide-metformin, or both for adolescents and women with hyperinsulinemic hyperandrogenism: opposite effects on adipocytokines and body adiposity.

The Journal of clinical endocrinology and metabolism 20040401

Metformin induced acute pancreatitis precipitated by renal failure.

Postgraduate medical journal 20040401

Effect of pramlintide on weight in overweight and obese insulin-treated type 2 diabetes patients.

Obesity research 20040401

Gastrointestinal tolerability of extended-release metformin tablets compared to immediate-release metformin tablets: results of a retrospective cohort study.

Current medical research and opinion 20040401

Experiences of a poison center with metformin-associated lactic acidosis.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20040401

[Effects of rosiglitazone and metformin on insulin resistance in high-fat diet rats].

Zhonghua nei ke za zhi 20040401

Should insulin-sensitizing drugs be used in the treatment of polycystic ovary syndrome?

Reproductive biomedicine online 20040401

The effect of oral folic acid on glutathione, glycaemia and lipids in Type 2 diabetes.

Diabetes, nutrition & metabolism 20040401

[Prevention by life style intervention and medication. To run away from type 2 diabetes].

MMW Fortschritte der Medizin 20040401

Activation of glycogen phosphorylase with 5-aminoimidazole-4-carboxamide riboside (AICAR). Assessment of glycogen as a precursor of mannosyl residues in glycoconjugates.

The Journal of biological chemistry 20040326

[Long-term HbA1c stable. Insulin sensitizer keeps diabetes in check].

MMW Fortschritte der Medizin 20040325

The combination of metformin and a dipeptidyl peptidase IV inhibitor prevents 5-fluorouracil-induced reduction of small intestine weight.

European journal of pharmacology 20040319

Metformin-stimulated mannose transport in dermal fibroblasts.

The Journal of biological chemistry 20040312

Fast liquid chromatographic-tandem mass spectrometric (LC-MS-MS) determination of metformin in plasma samples.

Journal of pharmaceutical and biomedical analysis 20040310

[Etiology of and therapy for type-2 diabetes mellitus].

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20040310

Optimal glycemic control in type 2 diabetes mellitus: fasting and postprandial glucose in context.

Archives of internal medicine 20040308

Type 2 diabetes mellitus: what is the optimal treatment regimen?

The American journal of medicine 20040308

Metformin hepatotoxicity.

Annals of internal medicine 20040302

Effects of insulin-sensitising agents in mice with hepatic insulin resistance.

Diabetologia 20040301

Prevention of weight gain in type 2 diabetes requiring insulin treatment.

Diabetes, obesity & metabolism 20040301

Pharmacologic therapy for HIV-associated lipodystrophy.

The Annals of pharmacotherapy 20040301

Metformin in the treatment of patients with non-alcoholic steatohepatitis.

Alimentary pharmacology & therapeutics 20040301

Diabetic ketoacidosis in a patient with chronic calcific pancreatitis after minor papilla stent insertion.

Gastrointestinal endoscopy 20040301

Metformin during pregnancy reduces insulin, insulin resistance, insulin secretion, weight, testosterone and development of gestational diabetes: prospective longitudinal assessment of women with polycystic ovary syndrome from preconception throughout pregnancy.

Human reproduction (Oxford, England) 20040301

Six-month treatment with low-dose dexamethasone further reduces androgen levels in PCOS women treated with diet and lifestyle advice, and metformin.

Human reproduction (Oxford, England) 20040301

Blood pressure and cardiac autonomic nervous system in obese type 2 diabetic patients: effect of metformin administration.

American journal of hypertension 20040301

Insulin resistance as a therapeutic target for improved endothelial function: metformin.

Current drug targets. Cardiovascular & haematological disorders 20040301

Pioglitazone reduces blood pressure in non-dipping diabetic patients.

Minerva endocrinologica 20040301

Combination of metformin and thiazolidindiones restore insulin signalling in insulin-resistant cultured myotubes.

Life sciences 20040227

Effects of exercise training and metformin on body composition and cardiovascular indices in HIV-infected patients.

AIDS (London, England) 20040220

Glycemic control with glyburide/metformin tablets in combination with rosiglitazone in patients with type 2 diabetes: a randomized, double-blind trial.

The American journal of medicine 20040215

Addition of pioglitazone or bedtime insulin to maximal doses of sulfonylurea and metformin in type 2 diabetes patients with poor glucose control: a prospective, randomized trial.

The American journal of medicine 20040215

The continuing legacy of the United Kingdom Prospective Diabetes Study.

The Medical journal of Australia 20040202

3.5 years of insulin therapy with insulin glargine improves in vivo endothelial function in type 2 diabetes.

Arteriosclerosis, thrombosis, and vascular biology 20040201

Effect of flutamide and metformin administered alone or in combination in dieting obese women with polycystic ovary syndrome.

Clinical endocrinology 20040201

Metformin and lactic acidosis: cause or coincidence? A review of case reports.

Journal of internal medicine 20040201

Mild cobalamin deficiency associated with long-term metformin intake--reply.

Journal of internal medicine 20040201

Diabetes in a nonpancreatectomized child with nesidioblastosis.

Diabetes care 20040201

Metformin in obstetric and gynecologic practice: a review.

Obstetrical & gynecological survey 20040201

Treatment of PCOS with metformin and other insulin-sensitizing agents.

Current diabetes reports 20040201

Effect of metformin treatment on multiple cardiovascular disease risk factors in patients with type 2 diabetes mellitus.

Metabolism: clinical and experimental 20040201

Nonobese women with polycystic ovary syndrome respond better than obese women to treatment with metformin.

Fertility and sterility 20040201

Dexamethasone reduces androgen levels in metformin-treated patients with polycystic ovary syndrome.

Fertility and sterility 20040201

The treatment of polycystic ovary syndrome.

Minerva ginecologica 20040201

Metformin for the treatment of the polycystic ovary syndrome.

Minerva ginecologica 20040201

Comparison of pioglitazone and metformin efficacy using homeostasis model assessment.

Diabetic medicine : a journal of the British Diabetic Association 20040201

Metformin-induced encephalopathy without lactic acidosis.

Diabetic medicine : a journal of the British Diabetic Association 20040201

[Lactic acidosis and acute abdomen from biguanide intoxication].

Der Anaesthesist 20040201

Beneficial effects of addition of oral spray insulin (Oralin) on insulin secretion and metabolic control in subjects with type 2 diabetes mellitus suboptimally controlled on oral hypoglycemic agents.

Diabetes technology & therapeutics 20040201

Simultaneous determination of metformin in combination with rosiglitazone by reversed-phase liquid chromatography.

Journal of chromatographic science 20040201

Intensive lifestyle changes or metformin in patients with impaired glucose tolerance: modeling the long-term health economic implications of the diabetes prevention program in Australia, France, Germany, Switzerland, and the United Kingdom.

Clinical therapeutics 20040201

Long-term glycaemic control with pioglitazone in patients with type 2 diabetes.

International journal of clinical practice 20040201

Survival after myocardial infarction in patients with type 2 diabetes.

JPMA. The Journal of the Pakistan Medical Association 20040201

Metformin and serious adverse effects.

The Medical journal of Australia 20040119

Use of metformin is a cause of vitamin B12 deficiency.

American family physician 20040115

The effect of metformin treatment to ovarian response in cases with PCOS.

Archives of gynecology and obstetrics 20040101

Effects of short-term metformin treatment on insulin sensitivity of blood glucose and free fatty acids.

Diabetes, obesity & metabolism 20040101

Decrease in serum C-reactive protein levels by troglitazone is associated with pretreatment insulin resistance, but independent of its effect on glycemia, in type 2 diabetic subjects.

Diabetes research and clinical practice 20040101

Favorable effects of pioglitazone and metformin compared with gliclazide on lipoprotein subfractions in overweight patients with early type 2 diabetes.

Diabetes care 20040101

One-year glycemic control with a sulfonylurea plus pioglitazone versus a sulfonylurea plus metformin in patients with type 2 diabetes.

Diabetes care 20040101

Nine weeks of bedtime diazoxide is well tolerated and improves beta-cell function in subjects with Type 2 diabetes.

Diabetic medicine : a journal of the British Diabetic Association 20040101

Metformin administration modulates and restores luteinizing hormone spontaneous episodic secretion and ovarian function in nonobese patients with polycystic ovary syndrome.

Fertility and sterility 20040101

Metformin therapy increases insulin-stimulated release of D-chiro-inositol-containing inositolphosphoglycan mediator in women with polycystic ovary syndrome.

The Journal of clinical endocrinology and metabolism 20040101

Modeling the efficiency of reaching a target intermediate end point: a case study in type 2 diabetes in the United States.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20040101

Insulin sensitization early after menarche prevents progression from precocious pubarche to polycystic ovary syndrome.

The Journal of pediatrics 20040101

Effects of short term metformin administration on androgens in diabetic men.

Saudi medical journal 20040101

Evaluation of the oral antihyperglycemic drug metformin in normal and diabetic cats.

Journal of veterinary internal medicine 20040101

Simultaneous high-performance liquid chromatographic determination of pioglitazone and metformin in pharmaceutical-dosage form.

Journal of chromatographic science 20040101

Complementary mode of action of rosiglitazone and metformin in a single tablet for the treatment of diabetes mellitus type 2.

Arzneimittel-Forschung 20040101

Should the insulin resistance syndrome be treated in the elderly?

Drugs & aging 20040101

Effects of a combination of recombinant human growth hormone with metformin on glucose metabolism and body composition in patients with metabolic syndrome.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20040101

Impact of adjunctive thiazolidinedione therapy on blood lipid levels and glycemic control in patients with type 2 diabetes.

Current medical research and opinion 20040101

Pioglitazone is effective therapy for elderly patients with type 2 diabetes mellitus.

Drugs & aging 20040101

Longitudinal metabolic observation of metformin effects during pregnancy in hyperinsulinemic women with polycystic ovary syndrome: a case report.

Journal of endocrinological investigation 20040101

[Acute kidney failure and severe lactic acidosis caused by metformin successfully treated with hemodialysis].

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20040101

[Treatment of adolescents with type 2 diabetes].

Klinische Padiatrie 20040101

Assessment of insulin resistance and effect of metformin in nonalcoholic steatohepatitis--a preliminary report.

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology 20040101

Metformin-associated respiratory alkalosis.

American journal of therapeutics 20040101

Mortality in type 2 diabetic subjects prescribed metformin and sulphonylurea drugs in combination: cohort study.

Diabetes/metabolism research and reviews 20040101

Metformin for prevention of type 2 diabetes.

The Annals of pharmacotherapy 20040101

Using metformin safely. X-ray with caution.

Diabetes self-management 20040101

Metformin extended release--DepoMed: metformin, metformin gastric retention, metformin GR.

Drugs in R&D 20040101

AMPK activation may suppress hepatic production of C-reactive protein by stimulating nitric oxide synthase.

Medical hypotheses 20040101

Chronic activation of AMP-activated kinase as a strategy for slowing aging.

Medical hypotheses 20040101

Does bitter melon contain an activator of AMP-activated kinase?

Medical hypotheses 20040101

Severe diarrhoea complicating metformin therapy: an unusual presentation.

Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria 20040101

Insulin as initial therapy for type 2 diabetes is not in the patient's best interest.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20040101

Insulin: thoroughly modern therapy.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20040101

Towards single-tablet therapy for type 2 diabetes mellitus. Rationale and recent developments.

Treatments in endocrinology 20040101

Extended-release metformin hydrochloride. Single-composition osmotic tablet formulation.

Treatments in endocrinology 20040101

Single-composition extended-release metformin hydrochloride. A viewpoint by David Bell.

Treatments in endocrinology 20040101

Single-composition extended-release metformin hydrochloride. A viewpoint by Vivian Fonseca.

Treatments in endocrinology 20040101

[Combined use of metformin and Diane35 in polycystic ovary syndrome].

Akusherstvo i ginekologiia 20040101

Transfer of metformin into human milk.

Advances in experimental medicine and biology 20040101

[Assessment of efficacy of combined therapy with antihypertensive agents and biguanides in patients with metabolic syndrome].

Kardiologiia 20040101

Community pharmacists' counseling about metformin-associated lactic acidosis.

Journal of the American Pharmacists Association : JAPhA 20040101

Metformin versus sibutramine in the treatment of hyperinsulinemia in chronically anovulating women.

Bratislavske lekarske listy 20040101

The efficacy of repaglinide monotherapy and in combination with metformin in Indonesian type 2 diabetes mellitus patients.

Acta medica Indonesiana 20040101

Tolerability profile of metformin/glibenclamide combination tablets (Glucovance): a new treatment for the management of type 2 diabetes mellitus.

Drug safety 20040101

[Efficacy and safety of glimepiride plus metformin in a single presentation, as combined therapy, in patients with type 2 diabetes mellitus and secondary failure to glibenclamide, as monotherapy].

Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion 20040101

Effects of KST48 [(2R,5SR)3-(2-chlorobenzoyl)-5-(4-chlorophenoxymethyl)-2(3,4-dichlorophenyl) oxazolidine] on glucose transport in L6 myocytes.

Arzneimittel-Forschung 20040101

Reversible renal insufficiency attributable to thyroid hormone withdrawal in a patient with type 2 diabetes mellitus.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20040101

Determination of metformin in plasma using a new ion pair solid phase extraction technique and ion pair liquid chromatography.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20031225

[Continuation 50. Type 2 diabetes: possibilities and limitations of pharmacological therapy].

MMW Fortschritte der Medizin 20031218

[Insulin resistance in polycystic ovary syndrome].

Wiener klinische Wochenschrift 20031215

[Blood sugar inspite of maximal metformin dosage. New fixed combination forces HbA1c down].

MMW Fortschritte der Medizin 20031211

Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association. October 7, 2003.

Circulation 20031209

Peroxisome proliferator-activated receptor-gamma agonists in atherosclerosis: current evidence and future directions.

Current opinion in lipidology 20031201

The role of metformin in the management of polycystic ovary syndrome.

Current opinion in obstetrics & gynecology 20031201

Therapy after single oral agent failure: adding a second oral agent or an insulin mixture?

Diabetes research and clinical practice 20031201

Metformin lactic acidosis, acute renal failure and rofecoxib.

British journal of anaesthesia 20031201

The combined effect of triple therapy with rosiglitazone, metformin, and insulin aspart in type 2 diabetic patients.

Diabetes care 20031201

Safety issues on metformin use.

Diabetes care 20031201

Comparison of repaglinide and nateglinide in combination with metformin: response to Raskin et al.

Diabetes care 20031201

Metabolic and psychosocial effects of minimal invasive gastric banding for morbid obesity.

Metabolism: clinical and experimental 20031201

Acarbose for the prevention of diabetes.

Cleveland Clinic journal of medicine 20031201

Acarbose for the prevention of diabetes.

Cleveland Clinic journal of medicine 20031201

Improvement of acanthosis nigricans on isotretinoin and metformin.

Journal of drugs in dermatology : JDD 20031201

[Endocrine and metabolic effects of metformin in combination with compound cyproterone acetate in women with polycystic ovarian syndrome].

Zhonghua fu chan ke za zhi 20031201

Metformin protects against carbon tetrachloride hepatotoxicity in mice.

Journal of pharmacological sciences 20031201

Metformin hydrochloride in the treatment of type 2 diabetes mellitus: a clinical review with a focus on dual therapy.

Clinical therapeutics 20031201

[The use of oral antidiabetic drugs in the treatment of polycystic ovary syndrome].

Zentralblatt fur Gynakologie 20031201

Role of oral anti-diabetic agents in modifying cardiovascular risk factors.

Minerva medica 20031201

[Progress in the prevention of type 2 diabetes].

Wiener klinische Wochenschrift 20031128

Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus: systematic review and meta-analysis.

Archives of internal medicine 20031124

[Physical activity in hyperglycemia and type 2 diabetes. Effective but still underutilized].

MMW Fortschritte der Medizin 20031120

[Metformin and lactic acidosis--fact or fiction? A review of current data].

Praxis 20031119

Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial.

Journal of internal medicine 20031101

Nitric oxide generation mediated by beta-adrenoceptors is impaired in platelets from patients with Type 2 diabetes mellitus.

Diabetologia 20031101

Obese patients with polycystic ovary syndrome: evidence that metformin does not restore sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by ovarian steroids.

The Journal of clinical endocrinology and metabolism 20031101

Comparison of additional metformin or NPH insulin to mealtime insulin lispro therapy with mealtime human insulin therapy in secondary OAD failure.

Diabetes, obesity & metabolism 20031101

Greater reductions in A1C in type 2 diabetic patients new to therapy with glyburide/metformin tablets as compared to glyburide co-administered with metformin.

Diabetes, obesity & metabolism 20031101

Effect of metformin on fibrinolytic parameters in insulin-treated, type 2 diabetic patients.

Diabetes & metabolism 20031101

Comparison of repaglinide vs. gliclazide in combination with bedtime NPH insulin in patients with Type 2 diabetes inadequately controlled with oral hypoglycaemic agents.

Diabetic medicine : a journal of the British Diabetic Association 20031101

Beneficial effects of triple drug combination of pioglitazone with glibenclamide and metformin in type 2 diabetes mellitus patients on insulin therapy.

The Journal of the Association of Physicians of India 20031101

Metformin in polycystic ovary syndrome: systematic review and meta-analysis.

BMJ (Clinical research ed.) 20031025

Genetic cause of hyperglycaemia and response to treatment in diabetes.

Lancet (London, England) 20031018

Metformin as additional therapy in adolescents with poorly controlled type 1 diabetes: randomised placebo-controlled trial with aspects on insulin sensitivity.

European journal of endocrinology 20031001

New drugs and dosage forms.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20031001

Metformin reduces serum C-reactive protein levels in women with polycystic ovary syndrome.

The Journal of clinical endocrinology and metabolism 20031001

Flutamide-metformin therapy to reduce fat mass in hyperinsulinemic ovarian hyperandrogenism: effects in adolescents and in women on third-generation oral contraception.

The Journal of clinical endocrinology and metabolism 20031001

Insulin-lowering agents in the management of polycystic ovary syndrome.

Endocrine reviews 20031001

Nonalcoholic steatohepatitis: role of leptin in pathogenesis and benefits of metformin in treatment.

The American journal of gastroenterology 20031001

Inadequacy of therapeutic education: a risk factor of hypoglycaemia.

Diabetes research and clinical practice 20031001

Recombinant glucagon-like peptide-1 (7-36 amide) lowers fasting serum glucose in a broad spectrum of patients with type 2 diabetes.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20031001

Effects of metformin or gemfibrozil on the lipodystrophy of HIV-infected patients receiving protease inhibitors.

Antiviral therapy 20031001

Unexpected survival from severe metformin-associated lactic acidosis.

The Netherlands journal of medicine 20031001

Treatment of atypical endometrial hyperplasia with an insulin-sensitizing agent.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20031001

[Is type-2 diabetes mellitus preventable?].

Orvosi hetilap 20030928

[Lactic acidosis as adverse effect of metformin].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20030925

[Optimized diabetes therapy in type 2 diabetics].

Medizinische Klinik (Munich, Germany : 1983) 20030915

Heart failure: treatment and ethnic origin.

Lancet (London, England) 20030913

Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death.

Endocrinology 20030901

Management of the overweight patient with Type 2 diabetes.

Diabetic medicine : a journal of the British Diabetic Association 20030901

Lipoprotein risk factors for cardiovascular disease in patients with type 2 diabetes mellitus treated with oral antihyperglycaemic agents.

Diabetes, obesity & metabolism 20030901

Within-trial cost-effectiveness of lifestyle intervention or metformin for the primary prevention of type 2 diabetes.

Diabetes care 20030901

Preventing, delaying, or masking type 2 diabetes with metformin in the diabetes prevention program?

Diabetes care 20030901

Metformin or antiandrogen in the treatment of hirsutism in polycystic ovary syndrome.

The Journal of clinical endocrinology and metabolism 20030901

Estimating the contribution of genes and environment to variation in renal drug clearance.

Pharmacogenetics 20030901

Current biochemical studies of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis suggest a new therapeutic approach.

The American journal of gastroenterology 20030901

Is metformin more than an oral hypoglycaemic agent?