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11097-69-1

11097-69-1 | Aroclor 1254, CAS 11097-69-1, 1000 µg/mL in n-Hexane

CAS No: 11097-69-1 Catalog No: AG01FO07 MDL No:

Product Description

Catalog Number:
AG01FO07
Chemical Name:
Aroclor 1254, CAS 11097-69-1, 1000 µg/mL in n-Hexane
CAS Number:
11097-69-1
IUPAC Name:
1,2,3-trichloro-4-(2,3-dichlorophenyl)benzene
InChI:
InChI=1S/C12H5Cl5/c13-8-3-1-2-6(10(8)15)7-4-5-9(14)12(17)11(7)16/h1-5H
InChI Key:
AUGNBQPSMWGAJE-UHFFFAOYSA-N
EC Number:
601-021-3
UNII:
88Z0CKE07W
RTECS Number:
TQ1360000
UN Number:
2315

Properties

Complexity:
259  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
325.88g/mol
Formal Charge:
0
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
0
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
326.422g/mol
Monoisotopic Mass:
323.883g/mol
Rotatable Bond Count:
1  
Topological Polar Surface Area:
0A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
6.7  

Literature

Title Journal
Sex differences in effects of gestational polychlorinated biphenyl exposure on hypothalamic neuroimmune and neuromodulator systems in neonatal rats. Toxicology and applied pharmacology 20180605
Lactational exposure of polychlorinated biphenyls impair Leydig cellular steroidogenesis in F(1) progeny rats. Reproductive toxicology (Elmsford, N.Y.) 20180101
Perinatal exposure to organohalogen pollutants decreases vasopressin content and its mRNA expression in magnocellular neuroendocrine cells activated by osmotic stress in adult rats. Toxicology and applied pharmacology 20170815
Polychlorinated biphenyls impair endometrial receptivity in vitro via regulating mir-30d expression and epithelial mesenchymal transition. Toxicology 20160715
A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens. Archives of toxicology 20151201
Inhibitory effects on osteoblast differentiation in vitro by the polychlorinated biphenyl mixture Aroclor 1254 are mainly associated with the dioxin-like constituents. Toxicology in vitro : an international journal published in association with BIBRA 20150801
The combined effects of DEHP and PCBs on phospholipase in the livers of mice. Environmental toxicology 20150201
Aroclor 1254-induced genotoxicity in male gonads through oxidatively damaged DNA and inhibition of DNA repair gene expression. Mutagenesis 20140901
Gestational and lactational exposure to the polychlorinated biphenyl mixture Aroclor 1254 modulates retinoid homeostasis in rat offspring. Toxicology letters 20140817
Augmented atherogenesis in ApoE-null mice co-exposed to polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicology and applied pharmacology 20140415
Estrogen receptors are involved in polychlorinated biphenyl-induced apoptosis on mouse spermatocyte GC-2 cell line. Toxicology in vitro : an international journal published in association with BIBRA 20140401
A novel MDCKII in vitro model for assessing ABCG2-drug interactions and regulation of ABCG2 transport activity in the caprine mammary gland by environmental pollutants and pesticides. Toxicology in vitro : an international journal published in association with BIBRA 20140401
YY162 prevents ADHD-like behavioral side effects and cytotoxicity induced by Aroclor1254 via interactive signaling between antioxidant potential, BDNF/TrkB, DAT and NET. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20140301
Non-dioxin-like PCBs inhibit [(3)H]WIN-35,428 binding to the dopamine transporter: a structure-activity relationship study. Neurotoxicology 20131201
A novel effect of polychlorinated biphenyls: impairment of the tight junctions in the mouse epididymis. Toxicological sciences : an official journal of the Society of Toxicology 20130801
Effects of oil pollution and persistent organic pollutants (POPs) on glycerophospholipids in liver and brain of male Atlantic cod (Gadus morhua). Chemosphere 20130201
Protective role of quercetin on polychlorinated biphenyls (Aroclor-1254) induced oxidative stress and apoptosis in liver of adult male rats. Journal of biochemical and molecular toxicology 20121201
Assessment of the antimutagenic effect of Doash tea extract fractions. Toxicology and industrial health 20121101
Aroclor 1254 selectively inhibits expression of glial GLT-1 glutamate transporter in the forebrain of chronically exposed adult rat. Toxicology 20121009
Developmental triclosan exposure decreases maternal, fetal, and early neonatal thyroxine: a dynamic and kinetic evaluation of a putative mode-of-action. Toxicology 20121009
Toxic effects of benzo[a]pyrene (Bap) and Aroclor1254 on embryogenesis, larval growth, survival and metamorphosis of the bivalve Meretrix meretrix. Ecotoxicology (London, England) 20120801
The metabonomics of combined dietary exposure to phthalates and polychlorinated biphenyls in mice. Journal of pharmaceutical and biomedical analysis 20120701
The toxic effects of Aroclor 1254 exposure on the osteoblastic cell line MC3T3-E1 and its molecular mechanism. Toxicology 20120516
Polychlorinated biphenyl congeners that increase the glucuronidation and biliary excretion of thyroxine are distinct from the congeners that enhance the serum disappearance of thyroxine. Drug metabolism and disposition: the biological fate of chemicals 20120301
Transferability of a modified embryonic stem cell test using a new endpoint for developmental neurotoxicity. Toxicology mechanisms and methods 20120201
Subchronic polychlorinated biphenyl (Aroclor 1254) exposure produces oxidative damage and neuronal death of ventral midbrain dopaminergic systems. Toxicological sciences : an official journal of the Society of Toxicology 20120201
Repeated exposure of adult rats to Aroclor 1254 induces neuronal injury and impairs the neurochemical manifestations of the NMDA receptor-mediated intracellular signaling in the hippocampus. Neurotoxicology 20120101
Perinatal exposure to environmental polychlorinated biphenyls sensitizes hippocampus to excitotoxicity ex vivo. Neurotoxicology 20111201
Aroclor 1254, a developmental neurotoxicant, alters energy metabolism- and intracellular signaling-associated protein networks in rat cerebellum and hippocampus. Toxicology and applied pharmacology 20111101
Dietary selenium as a modulator of PCB 126-induced hepatotoxicity in male Sprague-Dawley rats. Toxicological sciences : an official journal of the Society of Toxicology 20111101
Effects of developmental exposure to polychlorinated biphenyls and/or polybrominated diphenyl ethers on cochlear function. Toxicological sciences : an official journal of the Society of Toxicology 20111101
Aroclor1254 interferes with estrogen receptor-mediated neuroprotection against beta-amyloid toxicity in cholinergic SN56 cells. Neurochemistry international 20111001
Embryotoxicity of lead (II) acetate and aroclor 1254 using a new end point of the embryonic stem cell test. International journal of toxicology 20111001
Disruption of spermatogenesis and differential regulation of testicular estrogen receptor expression in mice after polychlorinated biphenyl exposure. Toxicology 20110905
The repressor element 1-silencing transcription factor is a novel molecular target for the neurotoxic effect of the polychlorinated biphenyl mixture aroclor 1254 in neuroblastoma SH-SY5Y cells. The Journal of pharmacology and experimental therapeutics 20110901
Aroclor 1254 disrupts liver glycogen metabolism and enhances acute stressor-mediated glycogenolysis in rainbow trout. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20110901
Enzyme-assisted synthesis of the glucuronide conjugate of psilocin, an hallucinogenic component of magic mushrooms. Drug testing and analysis 20110901
Role of quercetin on PCBs (Aroclor-1254) induced impairment of dopaminergic receptor mRNA expression in cerebral cortex of adult male rats. Neurochemical research 20110801
A preliminary investigation of the environmental impact of a thermal power plant in relation to PCB contamination. Environmental science and pollution research international 20110701
Hydrodechlorination of dichlorobenzenes and their derivatives over Ni-Mo/C catalyst: kinetic analysis and effect of molecular structure of reactant. Chemosphere 20110401
Differential effects of a complex organochlorine mixture on the proliferation of breast cancer cell lines. Environmental research 20110401
Differential expression of androgen and estrogen receptors in PCB (Aroclor 1254)-exposed rat ventral prostate: impact of alpha-tocopherol. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20110101
Enhanced hepatotoxicity induced by repeated exposure to polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin in combination in male rats. Journal of environmental sciences (China) 20110101
Tryptophan hydroxylase: a target for neuroendocrine disruption. Journal of toxicology and environmental health. Part B, Critical reviews 20110101
Elevated whole brain arginine vasotocin with Aroclor 1254 exposure in two Syngnathus pipefishes. Fish physiology and biochemistry 20101201
Effects of chronic dietary exposure to a low-dose of Malathion, Aroclor-1254 and 3-methylcholanthrene on three biomarkers in male mice. Acta biologica Hungarica 20101201
Disruption of thyroid hormone homeostasis in Ugt1a-deficient Gunn rats by microsomal enzyme inducers is not due to enhanced thyroxine glucuronidation. Toxicology and applied pharmacology 20101001
Modulatory effects of lycopene and ellagic acid on reproductive dysfunction induced by polychlorinated biphenyl (Aroclor 1254) in male rats. Basic & clinical pharmacology & toxicology 20100601
Regulation of cytochrome P450 expression in Drosophila: Genomic insights. Pesticide biochemistry and physiology 20100601
Changes in mitogen-activated protein kinase in cerebellar granule neurons by polybrominated diphenyl ethers and polychlorinated biphenyls. Toxicology and applied pharmacology 20100515
Effect of melatonin on PCB (Aroclor 1254) induced neuronal damage and changes in Cu/Zn superoxide dismutase and glutathione peroxidase-4 mRNA expression in cerebral cortex, cerebellum and hippocampus of adult rats. Neuroscience research 20100201
Hyper- and hypo-induction of cytochrome P450 activities with Aroclor 1254 and 3-methylcholanthrene in Cyp1a2(-/-) mice. Chemico-biological interactions 20091210
Stereoselective metabolism of the environmental mammary carcinogen 6-nitrochrysene to trans-1,2-dihydroxy-1,2-dihydro-6-nitrochrysene by aroclor 1254-treated rat liver microsomes and their comparative mutation profiles in a laci mammary epithelial cell line. Chemical research in toxicology 20091201
An exploratory study of diabetes in a First Nation community with respect to serum concentrations of p,p'-DDE and PCBs and fish consumption. International journal of environmental research and public health 20091201
Combined effects of repeated administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin and polychlorinated biphenyls on kidneys of male rats. Archives of environmental contamination and toxicology 20091101
Glutathione S-transferase as a biomarker in the Antarctic bivalve Laternula elliptica after exposure to the polychlorinated biphenyl mixture Aroclor 1254. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20091101
Aroclor 1254 induced cytotoxicity and mitochondrial dysfunction in isolated rat hepatocytes. Toxicology 20090821
Influence of aroclor 1254 on benzo(a)pyrene-induced DNA breakage, oxidative DNA damage, and cytochrome P4501A activity in human hepatoma cell line. Environmental toxicology 20090801
Aroclor 1254 impairs spermatogenesis and induces oxidative stress in rat testicular mitochondria. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090801
Oxidative stress alters creatine kinase system in serum and brain regions of polychlorinated biphenyl (Aroclor 1254)-exposed rats: protective role of melatonin. Basic & clinical pharmacology & toxicology 20090801
Protein expression profiling in the African clawed frog Xenopus laevis tadpoles exposed to the polychlorinated biphenyl mixture aroclor 1254. Molecular & cellular proteomics : MCP 20090401
Developmental exposure to polychlorinated biphenyls interferes with experience-dependent dendritic plasticity and ryanodine receptor expression in weanling rats. Environmental health perspectives 20090301
Effects of Aroclor 1254 on oxidative stress in developing Xenopus laevis tadpoles. Ecotoxicology and environmental safety 20090201
Two compartment model of diazepam biotransformation in an organotypical culture of primary human hepatocytes. Toxicology and applied pharmacology 20090115
Role of N-methyl-D-aspartate receptors in polychlorinated biphenyl mediated neurotoxicity. Toxicology letters 20090110
Studies on the protective role of lycopene against polychlorinated biphenyls (Aroclor 1254)-induced changes in StAR protein and cytochrome P450 scc enzyme expression on Leydig cells of adult rats. Reproductive toxicology (Elmsford, N.Y.) 20090101
Simultaneous extraction and clean-up of polychlorinated biphenyls and their metabolites from small tissue samples using pressurized liquid extraction. Journal of chromatography. A 20081219
Transcriptomic responses of European flounder (Platichthys flesus) to model toxicants. Aquatic toxicology (Amsterdam, Netherlands) 20081111
Protective role of melatonin on PCB (Aroclor 1,254) induced oxidative stress and changes in acetylcholine esterase and membrane bound ATPases in cerebellum, cerebral cortex and hippocampus of adult rat brain. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20081001
Transcriptional up-regulation of disk abalone selenium dependent glutathione peroxidase by H(2)O(2) oxidative stress and Vibrio alginolyticus bacterial infection. Fish & shellfish immunology 20081001
Expression profiling of interindividual variability following xenobiotic exposures in primary human hepatocyte cultures. Toxicology and applied pharmacology 20080901
Polychlorinated biphenyl (Aroclor 1254) inhibits testosterone biosynthesis and antioxidant enzymes in cultured rat Leydig cells. Reproductive toxicology (Elmsford, N.Y.) 20080801
Cross-talk between aryl hydrocarbon receptor and mitogen-activated protein kinase signaling pathway in liver cancer through c-raf transcriptional regulation. Molecular cancer research : MCR 20080801
Immuno-localisations (GSSP) of subcellular accumulation sites of phenanthrene, aroclor 1254 and lead (Pb) in relation to cytopathologies in the gills and digestive gland of the mussel Mytilus edulis. Marine environmental research 20080701
Characterization of the genotoxicity of nitrilotriacetic acid. Environmental and molecular mutagenesis 20080701
Attenuating effect of daidzein on polychlorinated biphenyls-induced oxidative toxicity in mouse testicular cells. Journal of Zhejiang University. Science. B 20080701
Toxicogenomic analysis of gender, chemical, and dose effects in livers of TCDD- or aroclor 1254-exposed rats using a multifactor linear model. Toxicological sciences : an official journal of the Society of Toxicology 20080401
Developmental exposure to polychlorinated biphenyls influences stroke outcome in adult rats. Environmental health perspectives 20080401
Detection of early signals of hepatotoxicity by gene expression profiling studies with cultures of metabolically competent human hepatocytes. Archives of toxicology 20080201
Polychlorinated biphenyl effects on avian hepatic enzyme induction and thyroid function. General and comparative endocrinology 20080201
Topoisomerase II inhibition involves characteristic chromosomal expression patterns. BMC genomics 20080101
Effects of Aroclor 1254 on femoral bone metabolism in adult male Wistar rats. Toxicology 20071130
Identification of new flavone-8-acetic acid metabolites using mouse microsomes and comparison with human microsomes. Drug metabolism and disposition: the biological fate of chemicals 20071101
Effects of polychlorinated biphenyls (PCBs) on expression of neurotrophic factors in C6 glial cells in culture. Neurotoxicology 20071101
Feminizing/demasculinizing effects of polychlorinated biphenyls on the secondary sexual development of Xenopus laevis. Aquatic toxicology (Amsterdam, Netherlands) 20071015
Piscine UDP-glucuronosyltransferase 1B. Aquatic toxicology (Amsterdam, Netherlands) 20071015
Oxidative stress modulates membrane bound ATPases in brain regions of PCB (Aroclor 1254) exposed rats: protective role of alpha-tocopherol. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20070801
Polychlorinated biphenyls modulated tumorigenesis in Sprague Dawley rats: correlation with mixed function oxidase activities and superoxide (O2* ) formation potentials and implied mode of action. Toxicological sciences : an official journal of the Society of Toxicology 20070801
Standardization of the perchlorate discharge assay for thyroid toxicity testing in rats. Regulatory toxicology and pharmacology : RTP 20070801
Cytotoxic effects and aromatase inhibition by xenobiotic endocrine disrupters alone and in combination. Toxicology and applied pharmacology 20070715
Polybrominated diphenyl ethers and ortho-substituted polychlorinated biphenyls as neuroendocrine disruptors of vasopressin release: effects during physiological activation in vitro and structure-activity relationships. Toxicological sciences : an official journal of the Society of Toxicology 20070701
Early embryonic exposure to polychlorinated biphenyls disrupts heat-shock protein 70 cognate expression in zebrafish. Journal of toxicology and environmental health. Part A 20070601
PCB (Aroclor 1254) enhances oxidative damage in rat brain regions: protective role of ascorbic acid. Neurotoxicology 20070501
Polychlorinated biphenyl-induced neurotoxicity in organotypic cocultures of developing rat ventral mesencephalon and striatum. Toxicological sciences : an official journal of the Society of Toxicology 20070501
Differential regulation of thyroid hormone receptor-mediated function by endocrine disruptors. Archives of pharmacal research 20070501
Effects of vitamins C and E on steroidogenic enzymes mRNA expression in polychlorinated biphenyl (Aroclor 1254) exposed adult rat Leydig cells. Toxicology 20070411
Protective effects of insulin on polychlorinated biphenyls-induced disruption of actin cytoskeleton in hippocampal neurons. Environmental toxicology 20070401
Effects of aqueous exposure to polychlorinated biphenyls (Aroclor 1254) on physiology and behavior of smolt development of Atlantic salmon. Aquatic toxicology (Amsterdam, Netherlands) 20070310
Ameliorative effect of vitamins (alpha-tocopherol and ascorbic acid) on PCB (Aroclor 1254) induced oxidative stress in rat epididymal sperm. Reproductive toxicology (Elmsford, N.Y.) 20070201
Effects of polychlorinated biphenyl (Aroclor 1254) on steroidogenesis and antioxidant system in cultured adult rat Leydig cells. The Journal of endocrinology 20070201
Comparative evaluation of hepatotoxic and nephrotoxic effects of aroclors 1221 and 1254 in female rats. Cell biochemistry and function 20070101
The thyroid disruptor 1,1,1-trichloro-2,2-bis(p-chlorophenyl)-ethane appears to be an uncompetitive inverse agonist for the thyrotropin receptor. The Journal of pharmacology and experimental therapeutics 20070101
Environmental estrogens induce mast cell degranulation and enhance IgE-mediated release of allergic mediators. Environmental health perspectives 20070101
Comparative 1-substituted imidazole inhibition of cytochrome p450 isozyme-selective activities in human and mouse hepatic microsomes. Drug metabolism reviews 20070101
Transcriptional profiling reveals barcode-like toxicogenomic responses in the zebrafish embryo. Genome biology 20070101
Role of alpha-tocopherol on antioxidant status in liver, lung and kidney of PCB exposed male albino rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20061201
Primary cultured cells as sensitive in vitro model for assessment of toxicants--comparison to hepatocytes and gill epithelia. Aquatic toxicology (Amsterdam, Netherlands) 20061116
Prenatal Aroclor 1254 exposure and brain sexual differentiation: effect on the expression of testosterone metabolizing enzymes and androgen receptors in the hypothalamus of male and female rats. Reproductive toxicology (Elmsford, N.Y.) 20061101
Thyroid hormone status of Atlantic croaker exposed to Aroclor 1254 and selected PCB congeners. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20061101
Modulatory effects of Aroclors 1221 and 1254 on bone turnover and vertebral histology in intact and ovariectomized rats. Toxicology letters 20061025
Polychlorinated biphenyl exposure delays metamorphosis and alters thyroid hormone system gene expression in developing Xenopus laevis. Environmental research 20061001
Identification, sequencing and expression of selenium-dependent glutathione peroxidase transcript in the freshwater bivalve Unio tumidus exposed to Aroclor 1254. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20061001
Involvement of the nitric oxide/protein kinase G pathway in polychlorinated biphenyl-induced cell death in SH-SY 5Y neuroblastoma cells. Journal of neuroscience research 20060815
Impact of heavy metals and organochlorines on hsp70 and hsc70 gene expression in black sea bream fibroblasts. Aquatic toxicology (Amsterdam, Netherlands) 20060812
Polychlorinated biphenyl-induced reduction of dopamine transporter expression as a precursor to Parkinson's disease-associated dopamine toxicity. Toxicological sciences : an official journal of the Society of Toxicology 20060801
PCB congener-specific disruption of reproductive neuroendocrine function in Atlantic croaker. Marine environmental research 20060701
In vitro basal and metabolism-mediated cytotoxicity of flavonoids. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20060601
Fasting augments PCB impact on liver metabolism in anadromous arctic char. Toxicological sciences : an official journal of the Society of Toxicology 20060601
Polychlorinated biphenyls, sex steroid hormones and liver retinoids in adult male European common frogs Rana temporaria. Chemosphere 20060501
Gene expression and estrogen sensitivity in rat uterus after developmental exposure to the polybrominated diphenylether PBDE 99 and PCB. Toxicology 20060315
Antioxidant effect of ascorbic acid on PCB (Aroclor 1254) induced oxidative stress in hypothalamus of albino rats. Clinica chimica acta; international journal of clinical chemistry 20060301
Heme-oxygenase-1 promotes polychlorinated biphenyl mixture aroclor 1254-induced oxidative stress and dopaminergic cell injury. Toxicological sciences : an official journal of the Society of Toxicology 20060301
Polychlorinated biphenyls alter expression of alpha-synuclein, synaptophysin and parkin in the rat brain. Toxicology letters 20060220
Polychlorinated biphenyls exert selective effects on cellular composition of white matter in a manner inconsistent with thyroid hormone insufficiency. Endocrinology 20060201
Ontogenetic alterations in prototypical transcription factors in the rat cerebellum and hippocampus following perinatal exposure to a commercial PCB mixture. Neurotoxicology 20060101
Selective metabolism of E-3,4-bis(4-ethylphenyl)hex-3-ene in rat liver microsomes. Archives of toxicology 20060101
Purkinje cell and cerebellar effects following developmental exposure to PCBs and/or MeHg. Neurotoxicology and teratology 20060101
Transcriptome profiling of human hepatocytes treated with Aroclor 1254 reveals transcription factor regulatory networks and clusters of regulated genes. BMC genomics 20060101
Involvement of calcium and calmodulin in the regulation of ovarian steroidogenesis in Atlantic croaker (Micropogonias undulatus) and modulation by Aroclor 1254. General and comparative endocrinology 20051201
Protective effect of quercetin on aroclor 1254-induced oxidative damage in cultured chicken spermatogonial cells. Toxicological sciences : an official journal of the Society of Toxicology 20051201
Apoptosis in bovine cumulus-oocyte complexes after exposure to polychlorinated biphenyl mixtures during in vitro maturation. Reproduction (Cambridge, England) 20051201
Studies on the protective role of vitamin C and E against polychlorinated biphenyl (Aroclor 1254)--induced oxidative damage in Leydig cells. Free radical research 20051101
Cytoprotective effect of green tea extract and quercetin against hydrogen peroxide-induced oxidative stress. Archives of pharmacal research 20051101
Involvement of Na+-Ca2+ exchanger in intracellular Ca2+ increase and neuronal injury induced by polychlorinated biphenyls in human neuroblastoma SH-SY5Y cells. The Journal of pharmacology and experimental therapeutics 20051001
Comparison of TCDD and PCB CYP1A induction sensitivities in fresh hepatocytes from human donors, sprague-dawley rats, and rhesus monkeys and HepG2 cells. Toxicological sciences : an official journal of the Society of Toxicology 20051001
Effect of Aroclor 1254 on Sertoli cellular antioxidant system, androgen binding protein and lactate in adult rat in vitro. Toxicology 20050901
Protective effects of antioxidant vitamins on Aroclor 1254-induced toxicity in cultured chicken embryo hepatocytes. Toxicology in vitro : an international journal published in association with BIBRA 20050801
Endocrine disruptive effects of polychlorinated biphenyls on the thyroid gland in female rats. The Tohoku journal of experimental medicine 20050801
Nile tilapia, Oreochromis niloticus L., reproduction inhibition by dietary exposure to Aroclor 1254. Bulletin of environmental contamination and toxicology 20050801
o-Aminoazotoluene does induce the enzymes of its own mutagenic activation in mouse liver. Toxicology 20050701
Treatment with a dietary fat substitute decreased Arochlor 1254 contamination in an obese diabetic male. The Journal of nutritional biochemistry 20050601
Dietary exposure to Aroclor 1254 alters gene expression in Xenopus laevis frogs. Environmental research 20050501
Maternal thyroid hormone increases HES expression in the fetal rat brain: an effect mimicked by exposure to a mixture of polychlorinated biphenyls (PCBs). Brain research. Developmental brain research 20050421
Organochlorine detection in the shed skins of snakes. Ecotoxicology and environmental safety 20050301
Early developmental exposure to BDE 99 or Aroclor 1254 affects neurobehavioural profile: interference from the administration route. Neurotoxicology 20050301
Toxic and hormonal effects of polychlorinated biphenyls on cultured testicular germ cells of embryonic chickens. Toxicology letters 20050215
Influence of polychlorinated biphenyls and turning preference on striatal dopamine metabolism. Journal of toxicology and environmental health. Part A 20050213
Impact of polychlorinated biphenyl Aroclor 1254 on testicular antioxidant system in adult rats. Human & experimental toxicology 20050201
Impact of PCB mixture (Aroclor 1254) and TBT and a mixture of both on swimming behavior, body growth and enzymatic biotransformation activities (GST) of young carp (Cyprinus carpio). Aquatic toxicology (Amsterdam, Netherlands) 20050118
Aroclor 1254 exposure reduces disease resistance and innate immune responses in fasted Arctic charr. Environmental toxicology and chemistry 20050101
The inhibitory effects of polychlorinated biphenyl Aroclor 1254 on Leydig cell LH receptors, steroidogenic enzymes and antioxidant enzymes in adult rats. Reproductive toxicology (Elmsford, N.Y.) 20050101
Effect of anaesthetics[sol ]terminal procedures on neurotransmitters from non-dosed and aroclor 1254-dosed rats. Journal of applied toxicology : JAT 20050101
Ontogenetic development, sexual differentiation, and effects of Aroclor 1254 exposure on expression of the arylhydrocarbon receptor and of the arylhydrocarbon receptor nuclear translocator in the rat hypothalamus. Reproductive toxicology (Elmsford, N.Y.) 20050101
Spatial alternation deficits following developmental exposure to Aroclor 1254 and/or methylmercury in rats. Toxicological sciences : an official journal of the Society of Toxicology 20041201
Polychlorinated biphenyl mixture aroclor 1254-induced oxidative stress plays a role in dopaminergic cell injury. Neurotoxicology 20041201
Differential in vitro neurotoxicity of the flame retardant PBDE-99 and of the PCB Aroclor 1254 in human astrocytoma cells. Toxicology letters 20041201
Effects of Vitamin C and E on PCB (Aroclor 1254) induced oxidative stress, androgen binding protein and lactate in rat Sertoli cells. Reproductive toxicology (Elmsford, N.Y.) 20041201
Developmental exposure to 4-hydroxy-2,3,3',4',5-pentachlorobiphenyl (4-OH-CB107): long-term effects on brain development, behavior, and brain stem auditory evoked potentials in rats. Toxicological sciences : an official journal of the Society of Toxicology 20041101
Estrogenic and toxic effects of polychlorinated biphenyls on cultured ovarian germ cells of embryonic chickens. Reproductive toxicology (Elmsford, N.Y.) 20041101
Metabolic fate of the Ah receptor ligand 6-formylindolo[3,2-b]carbazole. Chemico-biological interactions 20041015
Xenobiotic substances such as PCB mixtures (Aroclor 1254) and TBT can influence swimming behavior and biotransformation activity (GST) of carp (Cyprinus carpio). Environmental toxicology 20041001
Antioxidant role of zinc in PCB (Aroclor 1254) exposed ventral prostate of albino rats. The Journal of nutritional biochemistry 20041001
Promotion of thyroid tumors in rats by pregnenolone-16alpha-carbonitrile (PCN) and polychlorinated biphenyl (PCB). Toxicological sciences : an official journal of the Society of Toxicology 20040901
Dietary selenium supplementation prolongs pentobarbital induced hypnosis. The Journal of nutritional biochemistry 20040901
Inhibition of aroclor 1254-induced depletion of stored calcium prevents the cell death in catecholaminergic cells. Toxicology 20040805
Blarina brevicauda as a biological monitor of polychlorinated biphenyls: evaluation of hepatic cytochrome P450 induction. Environmental toxicology and chemistry 20040801
Effects of vitamin supplementation on PCB (Aroclor 1254)-induced changes in ventral prostatic androgen and estrogen receptors. Endocrine research 20040801
A comparative study of the expression of CYP1A and CYP4 genes in aquatic invertebrate (freshwater mussel, Unio tumidus) and vertebrate (rainbow trout, Oncorhynchus mykiss). Aquatic toxicology (Amsterdam, Netherlands) 20040730
Randomized controlled trial of dietary intervention: association between level of urinary phenolics and anti-mutagenicity. Mutation research 20040711
Aroclor 1254 inhibits tryptophan hydroxylase activity in rat brain. Archives of toxicology 20040601
Polychlorinated biphenyls (PCBs) exert thyroid hormone-like effects in the fetal rat brain but do not bind to thyroid hormone receptors. Environmental health perspectives 20040401
Impact of polychlorinated biphenyl (Aroclor 1254) and vitamin C on antioxidant system of rat ventral prostate. Asian journal of andrology 20040301
Early developmental neurotoxicity of a PCB/organochlorine mixture in rodents after gestational and lactational exposure. Toxicological sciences : an official journal of the Society of Toxicology 20040101
Antioxidant responses to benzo[a]pyrene and Aroclor 1254 exposure in the green-lipped mussel, Perna viridis. Environmental pollution (Barking, Essex : 1987) 20040101
Vitamin E co-treatment reduces Aroclor 1254-induced impairment of reproductive neuroendocrine function in Atlantic croaker. Marine environmental research 20040101
Subcritical (hot/liquid) water dechlorination of PCBs (Aroclor 1254) with metal additives and in waste paint. Environmental science & technology 20031215
Studies on the metabolism of the thiofurans furfuryl mercaptan and 2-methyl-3-furanthiol in rat liver. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20031201
Effect of polychlorinated biphenyl, Aroclor 1254 on rat epididymis. The Indian journal of medical research 20031201
Exposure and time dependent DNA strand breakage in hepatopancreas of green-lipped mussels (Perna viridis) exposed to Aroclor 1254, and mixtures of B[a]P and Aroclor 1254. Marine pollution bulletin 20031001
In vitro assay of thyroid disruptors affecting TSH-stimulated adenylate cyclase activity. Journal of endocrinological investigation 20031001
Effects of a mixture of polychlorinated biphenyls (Aroclor 1254) on the transcriptional activity of thyroid hormone receptor. Journal of endocrinological investigation 20031001
Benzo(a)pyrene induced micronucleus formation was modulated by persistent organic pollutants (POPs) in metabolically competent human HepG2 cells. Toxicology letters 20030930
Expression of drug-metabolizing enzymes, nuclear transcription factors and ABC transporters in Caco-2 cells. Xenobiotica; the fate of foreign compounds in biological systems 20030901
Polychlorinated biphenyls induce caspase-dependent cell death in cultured embryonic rat hippocampal but not cortical neurons via activation of the ryanodine receptor. Toxicology and applied pharmacology 20030701
Reductive dechlorination of polychlorinated biphenyls in sediment from the Twelve Mile Creek arm of Lake Hartwell, South Carolina, USA. Environmental toxicology and chemistry 20030601
Studies on the induction of rat hepatic CYP1A, CYP2B, CYP3A and CYP4A subfamily form mRNAs in vivo and in vitro using precision-cut rat liver slices. Xenobiotica; the fate of foreign compounds in biological systems 20030501
DNA adducts in cultures of polychlorinated biphenyl-treated human hepatocytes. Toxicology and applied pharmacology 20030415
Induction of T(4) UDP-GT activity, serum thyroid stimulating hormone, and thyroid follicular cell proliferation in mice treated with microsomal enzyme inducers. Toxicology and applied pharmacology 20030401
Changes in enantiomeric fractions during microbial reductive dechlorination of PCB132, PCB149, and araclor 1254 in Lake Hartwell sediment microcosms. Environmental science & technology 20030315
Inhibition of mutagenicity of food-derived heterocyclic amines by sulphoraphene--an isothiocyanate isolated from radish. Planta medica 20030201
Mutagenic activation of arylamines by subcellular fractions of Chamaelea gallina clams exposed to environmental pollutants. Environmental and molecular mutagenesis 20030101
Development of a DNA microarray for toxicology based on hepatotoxin-regulated sequences. EHP toxicogenomics : journal of the National Institute of Environmental Health Sciences 20030101
Polychlorinated biphenyls alter extraneuronal but not tissue dopamine concentrations in adult rat striatum: an in vivo microdialysis study. Environmental health perspectives 20021101
A novel mechanism for endocrine-disrupting effects of polychlorinated biphenyls: direct effects on gonadotropin-releasing hormone neurones. Journal of neuroendocrinology 20021001
Activity of protein kinase C modulates the apoptosis induced by polychlorinated biphenyls in human leukemic HL-60 cells. Toxicology letters 20020905
Effects of perinatal exposure to a polybrominated diphenyl ether (PBDE 99) on mouse neurobehavioural development. Neurotoxicology 20020901
Aroclor 1254-induced cytotoxicity in catecholaminergic CATH.a cells related to the inhibition of NO production. Toxicology 20020815
Polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs) and chlorinated paraffins (CPs) in rats-testing interactions and mechanisms for thyroid hormone effects. Toxicology 20020815
Neurobehavioral assessments of rats perinatally exposed to a commercial mixture of polychlorinated biphenyls. Toxicological sciences : an official journal of the Society of Toxicology 20020701
In vitro toxicity and interactions of environmental contaminants (Arochlor 1254 and mercury) and immunomodulatory agents (lipopolysaccharide and cortisol) on thymocytes from lake trout (Salvelinus namaycush). Fish & shellfish immunology 20020701
Effects of PCB exposure on the toxic impact of organophosphorus insecticides. Toxicological sciences : an official journal of the Society of Toxicology 20020601
Polychlorinated biphenyl-induced apoptosis of murine spleen cells is aryl hydrocarbon receptor independent but caspases dependent. Toxicology and applied pharmacology 20020601
Fasting modifies Aroclor 1254 impact on plasma cortisol, glucose and lactate responses to a handling disturbance in Arctic charr. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20020601
Proacrosin-deficient mice and zona pellucida modifications in an experimental model of multifactorial infertility. Molecular human reproduction 20020501
The polychlorinated biphenyl mixture aroclor 1254 induces death of rat cerebellar granule cells: the involvement of the N-methyl-D-aspartate receptor and reactive oxygen species. Toxicology and applied pharmacology 20020315
Polychlorinated biphenyls interfere with androgen-induced transcriptional activation and hormone binding. Toxicology and applied pharmacology 20020315
Increase in rat liver UDP-glucuronosyltransferase mRNA by microsomal enzyme inducers that enhance thyroid hormone glucuronidation. Drug metabolism and disposition: the biological fate of chemicals 20020301
Microsomal activation of dibenzo[def,mno]chrysene (anthanthrene), a hexacyclic aromatic hydrocarbon without a bay-region, to mutagenic metabolites. Chemical research in toxicology 20020301
Effect of microsomal enzyme inducers on the biliary excretion of triiodothyronine (T(3)) and its metabolites. Toxicological sciences : an official journal of the Society of Toxicology 20020201
Damaging effects of polychlorinated biphenyls on chicken primordial germ cells. Reproduction, fertility, and development 20020101
Identification of differentially expressed genes in Dreissena polymorpha exposed to contaminants. Marine environmental research 20020101
Induction of DNA strand breakage and apoptosis in the eel Anguilla anguilla. Marine environmental research 20020101
Identification of calcium-dependent and -independent signaling pathways involved in polychlorinated biphenyl-induced cyclic AMP-responsive element-binding protein phosphorylation in developing cortical neurons. Neuroscience 20020101
Differential effects of two lots of aroclor 1254: congener-specific analysis and neurochemical end points. Environmental health perspectives 20011101
Differential effects of two lots of aroclor 1254 on enzyme induction, thyroid hormones, and oxidative stress. Environmental health perspectives 20011101
Increased biliary excretion of thyroxine by microsomal enzyme inducers. Toxicology and applied pharmacology 20011101
Aroclor 1254 inhibits the mitochondrial permeability transition and release of cytochrome c: a possible mechanism for its in vivo toxicity. Toxicology and applied pharmacology 20011015
Effects of neonatal polychlorinated biphenyl exposure on female sexual behavior. Physiology & behavior 20011001
Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles. Toxicology and applied pharmacology 20010815
Hepatocellular iron accumulation and increased cell proliferation in polychlorinated biphenyl-exposed Sprague-Dawley rats and the development of hepatocarcinogenesis. Toxicological sciences : an official journal of the Society of Toxicology 20010701
Perinatal exposure to polychlorinated biphenyls Aroclor 1016 or 1254 did not alter brain catecholamines nor delayed alternation performance in Long-Evans rats. Brain research bulletin 20010701
Developmental exposure of rats to a reconstituted PCB mixture or aroclor 1254: effects on long-term potentiation and [3H]MK-801 binding in occipital cortex and hippocampus. Toxicological sciences : an official journal of the Society of Toxicology 20010601
A comparison of aroclor 1254-induced and uninduced rat liver microsomes to human liver microsomes in phenytoin O-deethylation, coumarin 7-hydroxylation, tolbutamide 4-hydroxylation, S-mephenytoin 4'-hydroxylation, chloroxazone 6-hydroxylation and testosterone 6beta-hydroxylation. Chemico-biological interactions 20010516
Optimization of an exogenous metabolic activation system for FETAX. I. Post-isolation rat liver microsome mixtures. Drug and chemical toxicology 20010501
Microarray analysis of hepatotoxins in vitro reveals a correlation between gene expression profiles and mechanisms of toxicity. Toxicology letters 20010331
Pilot studies evaluating the lung tumor yield in cigarette smoke-exposed mice. International journal of oncology 20010301
Disruption of neuroendocrine control of luteinizing hormone secretion by aroclor 1254 involves inhibition of hypothalamic tryptophan hydroxylase activity. Biology of reproduction 20010301
Environmental toxicant effects on neuroendocrine function. Endocrine 20010301
The effect of polychlorinated biphenyls on the high affinity uptake of the neurotransmitters, dopamine, serotonin, glutamate and GABA, into rat brain synaptosomes. Toxicology 20010221
Induction of nuclear transcription factors, cytochrome P450 monooxygenases, and glutathione S-transferase alpha gene expression in Aroclor 1254-treated rat hepatocyte cultures. Biochemical pharmacology 20010115
Effects of xenoestrogen treatment on zona radiata protein and vitellogenin expression in Atlantic salmon (Salmo salar). Aquatic toxicology (Amsterdam, Netherlands) 20000601
Lead and Aroclor 1254 disrupt reproductive neuroendocrine function in Atlantic croaker. Marine environmental research 20000101
Levels and membrane localization of the c-K-ras p21 protein in lungs of mice of different genetic strains and effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and Aroclor 1254. Carcinogenesis 19980301
Modulation of the hepatic expression of the estrogen-regulated mRNA stabilizing factor by estrogenic and antiestrogenic nonsteroidal xenobiotics. Biochemical pharmacology 19970515
Interaction with the aromatic hydrocarbon receptor, CYP1A induction, and mutagenicity of a series of diaminotoluenes: implications for their carcinogenicity. Toxicology and applied pharmacology 19960701
Oxidative stress in fish exposed to model xenobiotics. Oxidatively modified forms of Cu,Zn-superoxide dismutase as potential biomarkers. Chemico-biological interactions 19951222
Promotion of N-nitrosodiethylamine-initiated hepatocellular tumors and hepatoblastomas by 2,3,7,8-tetrachlorodibenzo-p-dioxin or Aroclor 1254 in C57BL/6, DBA/2, and B6D2F1 mice. Cancer research 19951101
Dissimilar frequency of hepatoblastomas and hepatic cystadenomas and adenocarcinomas arising in hepatocellular neoplasms of D2B6F1 mice initiated with N-nitrosodiethylamine and subsequently given Aroclor-1254, dichlorodiphenyltrichloroethane, or phenobarbital. Toxicologic pathology 19940101
1-Nitronaphthalene toxicity in rat lung and liver: effects of inhibiting and inducing cytochrome P450 activity. Toxicology and applied pharmacology 19931001
Transplacental transfer of polychlorinated biphenyls induces simultaneously the expression of P450 isoenzymes and the protooncogenes c-Ha-ras and c-raf. Biochemical pharmacology 19930406
Search for Ha-ras codon 61 mutations in liver tumours caused by hexachlorobenzene and Aroclor 1254 in C57BL/10ScSn mice with iron overload. Carcinogenesis 19921001
Protective role of aqueous turmeric extract against mutagenicity of direct-acting carcinogens as well as benzo [alpha] pyrene-induced genotoxicity and carcinogenicity. Journal of cancer research and clinical oncology 19920101
Activation of amino-alpha-carboline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and a copper phthalocyanine cellulose extract of cigarette smoke condensate by cytochrome P-450 enzymes in rat and human liver microsomes. Cancer research 19911001
Induction of hepatic cytochrome P-450IA1 in pigeons treated in vivo with Aroclor 1254, a commercial mixture of polychlorinated biphenyls (PCBs). Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology 19910101
Regulation of cytochrome P-450j, a high-affinity N-nitrosodimethylamine demethylase, in rat hepatic microsomes. Biochemistry 19870421
Detoxifying activities in alveolar macrophages of rats treated with acetylcysteine, diethyl maleate and/or aroclor. Anticancer research 19860101
Prominent role of DT-diaphorase as a cellular mechanism reducing chromium(VI) and reverting its mutagenicity. Cancer research 19850701
Modifications in the myeloclastogenic effect of benzene in mice with toluene, phenobarbital, 3-methylcholanthrene, Aroclor 1254 and SKF-525A. Mutation research 19840301
Modification of hexachlorophene toxicity by dieldrin and aroclor 1254. Toxicology 19740901

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