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1094-61-7

1094-61-7 | β-Nicotinamide mononucleotide

CAS No: 1094-61-7 Catalog No: AG003880 MDL No:MFCD00038748

Product Description

Catalog Number:
AG003880
Chemical Name:
β-Nicotinamide mononucleotide
CAS Number:
1094-61-7
Molecular Formula:
C11H15N2O8P
Molecular Weight:
334.2192
MDL Number:
MFCD00038748
IUPAC Name:
[(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate
InChI:
InChI=1S/C11H15N2O8P/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19/h1-4,7-9,11,14-15H,5H2,(H3-,12,16,17,18,19)/t7-,8-,9-,11-/m1/s1
InChI Key:
DAYLJWODMCOQEW-TURQNECASA-N
SMILES:
O[C@@H]1[C@H](O)[C@H](O[C@H]1[n+]1cccc(c1)C(=O)N)COP(=O)(O)[O-]
EC Number:
214-136-5
UNII:
2KG6QX4W0V

Properties

Complexity:
455  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Defined Bond Stereocenter Count:
0
Exact Mass:
334.057g/mol
Formal Charge:
0
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0
Molecular Weight:
334.221g/mol
Monoisotopic Mass:
334.057g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
166A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-3.5  

Literature

Title Journal
Oxyresveratrol stimulates mucin production in an NAD(+)-dependent manner in human intestinal goblet cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20180801
METALLOPROTEINS. A tethered niacin-derived pincer complex with a nickel-carbon bond in lactate racemase. Science (New York, N.Y.) 20150703
A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome. Cell metabolism 20141104
Elevated microRNA-34a in obesity reduces NAD+ levels and SIRT1 activity by directly targeting NAMPT. Aging cell 20131201
Resistin impairs SIRT1 function and induces senescence-associated phenotype in hepatocytes. Molecular and cellular endocrinology 20130905
A urinary metabonomics study on biochemical changes in yeast-induced pyrexia rats: a new approach to elucidating the biochemical basis of the febrile response. Chemico-biological interactions 20130625
Comparison of the formation of nicotinic acid conjugates in leaves of different plant species. Plant physiology and biochemistry : PPB 20121101
Induced fit and the catalytic mechanism of isocitrate dehydrogenase. Biochemistry 20120911
Molecular determinants of ligand selectivity for the human multidrug and toxin extruder proteins MATE1 and MATE2-K. The Journal of pharmacology and experimental therapeutics 20120601
Enzymatic biofuel cells utilizing a biomimetic cofactor. Chemical communications (Cambridge, England) 20120211
Characterization of human nicotinate phosphoribosyltransferase: Kinetic studies, structure prediction and functional analysis by site-directed mutagenesis. Biochimie 20120201
Effects of long-acting somatostatin analogues on adrenal growth and phosphoribosyl pyrophosphate formation in experimental diabetes. International journal of experimental pathology 20120201
Catalysis-based inhibitors of the calcium signaling function of CD38. Biochemistry 20120110
The high-resolution crystal structure of periplasmic Haemophilus influenzae NAD nucleotidase reveals a novel enzymatic function of human CD73 related to NAD metabolism. The Biochemical journal 20120101
Identification of mitochondrial electron transport chain-mediated NADH radical formation by EPR spin-trapping techniques. Biochemistry 20111220
Nicotinamide mononucleotide protects against pro-inflammatory cytokine-mediated impairment of mouse islet function. Diabetologia 20111201
Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell metabolism 20111005
Mitochondria-localized NAD biosynthesis by nicotinamide mononucleotide adenylyltransferase in Jerusalem artichoke (Helianthus tuberosus L.) heterotrophic tissues. Planta 20111001
Effect of nicotinamide mononucleotide on insulin secretion and gene expressions of PDX-1 and FoxO1 in RIN-m5f cells. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20111001
ArsAB, a novel enzyme from Sporomusa ovata activates phenolic bases for adenosylcobamide biosynthesis. Molecular microbiology 20110801
A fluorometric assay for high-throughput screening targeting nicotinamide phosphoribosyltransferase. Analytical biochemistry 20110501
Comparative genomics of NAD(P) biosynthesis and novel antibiotic drug targets. Journal of cellular physiology 20110201
Wld(S) reduces paraquat-induced cytotoxicity via SIRT1 in non-neuronal cells by attenuating the depletion of NAD. PloS one 20110101
Nicotinamide phosphoribosyltransferase/visfatin does not catalyze nicotinamide mononucleotide formation in blood plasma. PloS one 20110101
Recognition of nucleoside monophosphate substrates by Haemophilus influenzae class C acid phosphatase. Journal of molecular biology 20101210
A possibility of nutriceuticals as an anti-aging intervention: activation of sirtuins by promoting mammalian NAD biosynthesis. Pharmacological research 20100701
Visualization and quantification of NAD(H) in brain sections by a novel histo-enzymatic nitrotetrazolium blue staining technique. Brain research 20100226
Identification of Isn1 and Sdt1 as glucose- and vitamin-regulated nicotinamide mononucleotide and nicotinic acid mononucleotide [corrected] 5'-nucleotidases responsible for production of nicotinamide riboside and nicotinic acid riboside. The Journal of biological chemistry 20091211
Detection and pharmacological modulation of nicotinamide mononucleotide (NMN) in vitro and in vivo. Biochemical pharmacology 20090515
Tailoring RNA modular units on a common scaffold: a modular ribozyme with a catalytic unit for beta-nicotinamide mononucleotide-activated RNA ligation. RNA (New York, N.Y.) 20090501
Mechanism-based small molecule probes for labeling CD38 on live cells. Journal of the American Chemical Society 20090211
Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: role of nicotinamide mononucleotide. Cardiovascular research 20090201
Extracellular Nampt promotes macrophage survival via a nonenzymatic interleukin-6/STAT3 signaling mechanism. The Journal of biological chemistry 20081212
Theoretical studies of the quinolinic acid to nicotinic acid mononucleotide transformation. The Journal of organic chemistry 20081205
Visfatin: a new player in mesangial cell physiology and diabetic nephropathy. American journal of physiology. Renal physiology 20081101
Weak coupling of ATP hydrolysis to the chemical equilibrium of human nicotinamide phosphoribosyltransferase. Biochemistry 20081021
Covalent and noncovalent intermediates of an NAD utilizing enzyme, human CD38. Chemistry & biology 20081020
Biosynthesis of trigonelline from nicotinate mononucleotide in mungbean seedlings. Phytochemistry 20080101
Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice. Aging cell 20080101
Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme. Cell metabolism 20071101
Crystal structure of human nicotinamide riboside kinase. Structure (London, England : 1993) 20070801
Nicotinamidase participates in the salvage pathway of NAD biosynthesis in Arabidopsis. The Plant journal : for cell and molecular biology 20070301
Arabidopsis thaliana nicotinate/nicotinamide mononucleotide adenyltransferase (AtNMNAT) is required for pollen tube growth. The Plant journal : for cell and molecular biology 20070201
Crystal structure of visfatin/pre-B cell colony-enhancing factor 1/nicotinamide phosphoribosyltransferase, free and in complex with the anti-cancer agent FK-866. Journal of molecular biology 20060908
Probing hot spots at protein-ligand binding sites: a fragment-based approach using biophysical methods. Journal of medicinal chemistry 20060810
The simultaneous measurement of nicotinamide adenine dinucleotide and related compounds by liquid chromatography/electrospray ionization tandem mass spectrometry. Analytical biochemistry 20060515
Crystal structure of quinolinic acid phosphoribosyltransferase from Helicobacter pylori. Proteins 20060401
The first crystal structure of a thioacylenzyme intermediate in the ALDH family: new coenzyme conformation and relevance to catalysis. Biochemistry 20060307
NAD(P) synthesis and pyridine nucleotide cycling in plants and their potential importance in stress conditions. Journal of experimental botany 20060101
Construction of an artificial ribozyme which ligates an RNA fragment activated by nicotinamide mononucleotide. Nucleic acids symposium series (2004) 20060101
NAD-, NMN-, and NADP-dependent modification of dinitrogenase reductases from Rhodospirillum rubrum and Azotobacter vinelandii. FEBS letters 20051024
Interactions between melatonin and nicotinamide nucleotide: NADH preservation in cells and in cell-free systems by melatonin. Journal of pineal research 20050901
NAD deamidation 'a new reaction' by an enzyme from Aspergillus terreus DSM 826. Antonie van Leeuwenhoek 20050201
NAD+ specificity of bacterial DNA ligase revealed. Structure (London, England : 1993) 20040801
Structural rearrangement accompanying NAD+ synthesis within a bacterial DNA ligase crystal. Structure (London, England : 1993) 20040801
Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. Cell 20040514
Structure and function of nicotinamide mononucleotide adenylyltransferase. Current medicinal chemistry 20040401
ADP-ribosyl cyclase; crystal structures reveal a covalent intermediate. Structure (London, England : 1993) 20040301
Effects of hydrogen peroxide upon nicotinamide nucleotide metabolism in Escherichia coli: changes in enzyme levels and nicotinamide nucleotide pools and studies of the oxidation of NAD(P)H by Fe(III). The Journal of biological chemistry 20031024
Porin OmpP2 of Haemophilus influenzae shows specificity for nicotinamide-derived nucleotide substrates. The Journal of biological chemistry 20030704
Crystallization and preliminary X-ray crystallographic analysis of quinolinate phosphoribosyltransferase of Helicobacter pylori. Acta crystallographica. Section D, Biological crystallography 20030701
Identification and characterization of a second NMN adenylyltransferase gene in Saccharomyces cerevisiae. Protein expression and purification 20030201
Crystal structure and site-directed mutagenesis of enzymatic components from Clostridium perfringens iota-toxin. Journal of molecular biology 20030117
Substrate specificity of mammalian pyridine nucleotide transglycosidases. Journal of nutritional science and vitaminology 20020601
Synthesis of pyridine nucleotide analogs consisting of nicotinoylamino acids by means of transglycosidation reactions catalyzed by mammalian pyridine nucleotide transglycosidases. Journal of nutritional science and vitaminology 20020601
Crystal structure of human nicotinamide mononucleotide adenylyltransferase in complex with NMN. FEBS letters 20020410
Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities. Journal of molecular biology 20020222
Purification and structure of the major product obtained by reaction of NADPH and NMNH with the myeloperoxidase/hydrogen peroxide/chloride system. European journal of biochemistry 20010501
A disubstituted NAD+ analogue is a nanomolar inhibitor of trypanosomal glyceraldehyde-3-phosphate dehydrogenase. Bioorganic & medicinal chemistry letters 20010122
Mechanism and activation for allosteric adenosine 5'-monophosphate nucleosidase. Kinetic alpha-deuterium isotope effects for the enzyme-catalyzed hydrolysis of adenosine 5'-monophosphate and nicotinamide mononucleotide. The Journal of biological chemistry 19860405

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