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Home > Imidazoles > 106807-72-1
106807-72-1 | 5-[2,2,2-trideuterio-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole;hydrochloride
CAS No: 106807-72-1 Catalog No: AG00830P MDL No:
Product Description
Catalog Number:
AG00830P
Chemical Name:
5-[2,2,2-trideuterio-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole;hydrochloride
CAS Number:
106807-72-1
Molecular Formula:
C13H17ClN2
Molecular Weight:
236.7405
IUPAC Name:
5-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole;hydrochloride
InChI:
InChI=1S/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13;/h4-8,11H,1-3H3,(H,14,15);1H
InChI Key:
VPNGEIHDPSLNMU-UHFFFAOYSA-N
SMILES:
Cc1cccc(c1C)C(c1cnc[nH]1)C.Cl
Properties
Complexity:
205
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
236.108g/mol
Formal Charge:
0
Heavy Atom Count:
16
Hydrogen Bond Acceptor Count:
1
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
236.743g/mol
Monoisotopic Mass:
236.108g/mol
Rotatable Bond Count:
2
Topological Polar Surface Area:
28.7A^2
Undefined Atom Stereocenter Count:
1
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
| Role of the equine CYP3A94, CYP3A95 and CYP3A97 in ketamine metabolism in presence of medetomidine, diazepam and methadone studied by enantioselective capillary electrophoresis. | Toxicology in vitro : an international journal published in association with BIBRA 20180801 |
| α2C-Adrenoceptors modulate L-DOPA uptake in opossum kidney cells and in the mouse kidney. | American journal of physiology. Renal physiology 20121001 |
| Central vagal activation by alpha(2) -adrenergic stimulation is impaired in spontaneously hypertensive rats. | Acta physiologica (Oxford, England) 20120901 |
| Comparison of S(+)-ketamine and ketamine, with medetomidine, for field anaesthesia in the European brown hare (Lepus europaeus). | Veterinary anaesthesia and analgesia 20120901 |
| Evaluation of effectiveness, safety and reliability of intramuscular medetomidine-ketamine for captive great apes. | The Veterinary record 20120825 |
| Ephedrine accelerates psychomotor recovery from anesthesia in macaque monkeys. | Journal of medical primatology 20120801 |
| Effects of intramuscular administration of tiletamine-zolazepam with and without sedative pretreatment on plasma and serum biochemical values and glucose tolerance test results in Japanese black bears (Ursus thibetanus japonicus). | American journal of veterinary research 20120801 |
| Preliminary studies of chemical immobilization of captive juvenile estuarine (Crocodylus porosus) and Australian freshwater (C. johnstoni) crocodiles with medetomidine and reversal with atipamezole. | Veterinary anaesthesia and analgesia 20120701 |
| Use of a medetomidine-ketamine combination for anesthesia in captive common hippopotami (Hippopotamus amphibius). | Journal of the American Veterinary Medical Association 20120701 |
| Medetomidine immobilisation and atipamezole reversal in large estuarine crocodiles (Crocodylus porosus) using metabolically scaled dosages. | Australian veterinary journal 20120601 |
| Apoptotic neurodegeneration and spatial memory are not affected by sedative and anaesthetics doses of ketamine/medetomidine combinations in adult mice. | British journal of anaesthesia 20120501 |
| Medetomidine continuous rate intravenous infusion in horses in which surgical anaesthesia is maintained with isoflurane and intravenous infusions of lidocaine and ketamine. | Veterinary anaesthesia and analgesia 20120501 |
| Effect of medetomidine-butorphanol and dexmedetomidine-butorphanol combinations on intraocular pressure in healthy dogs. | Veterinary anaesthesia and analgesia 20120501 |
| Cardiopulmonary and sedative effects of the peripheral α2-adrenoceptor antagonist MK 0467 administered intravenously or intramuscularly concurrently with medetomidine in dogs. | American journal of veterinary research 20120501 |
| Comparison of the effects of xylazine bolus versus medetomidine constant rate infusion on cardiopulmonary function and depth of anesthesia in horses anesthetized with isoflurane. | Journal of the American Veterinary Medical Association 20120415 |
| Comparison of the effects of xylazine bolus versus medetomidine constant rate infusion on the stress response, urine production, and anesthetic recovery characteristics in horses anesthetized with isoflurane. | Journal of the American Veterinary Medical Association 20120415 |
| Effects of medetomidine and ketamine on the regional cerebral blood flow in cats: a SPECT study. | Veterinary journal (London, England : 1997) 20120401 |
| The effect of repetitive intraperitoneal anesthesia by application of fentanyl-medetomidine and midazolam in laboratory rats. | Journal of investigative surgery : the official journal of the Academy of Surgical Research 20120401 |
| Field immobilization of feral 'Judas' donkeys (Equus asinus) by remote injection of medetomidine and ketamine and antagonism with atipamezole. | Journal of wildlife diseases 20120401 |
| Optimal medetomidine dose when combined with ketamine and tiletamine-zolazepam to immobilize white-tailed deer. | Journal of wildlife diseases 20120401 |
| Pharmacological modulation of functional connectivity: α2-adrenergic receptor agonist alters synchrony but not neural activation. | NeuroImage 20120301 |
| A comparison of two different ketamine and diazepam combinations with an alphaxalone and medetomidine combination for induction of anaesthesia in sheep. | New Zealand veterinary journal 20120301 |
| Low frequency stimulation of the perforant pathway generates anesthesia-specific variations in neural activity and BOLD responses in the rat dentate gyrus. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20120201 |
| Developmental and behavioral effects of medetomidine following in ovo injection in chicks. | Neurotoxicology and teratology 20120101 |
| Transplacental transfer of medetomidine and ketamine in pregnant ewes. | Laboratory animals 20120101 |
| Medetomidine, an α(2)-adrenergic agonist, activates cardiac vagal nerve through modulation of baroreflex control. | Circulation journal : official journal of the Japanese Circulation Society 20120101 |
| Pharmacokinetics and pharmacodynamics of intravenous medetomidine in the horse. | Veterinary anaesthesia and analgesia 20120101 |
| Medetomidine-ketamine-isoflurane anaesthesia in pygmy hippopotami (Choeropsis liberiensis)--a case series. | Veterinary anaesthesia and analgesia 20120101 |
| Chemical immobilization of raccoons (Procyon lotor) with ketamine-medetomidine mixture and reversal with atipamezole. | Journal of wildlife diseases 20120101 |
| Inhibition of firefly luciferase by general anesthetics: effect on in vitro and in vivo bioluminescence imaging. | PloS one 20120101 |
| Short-term effects of medetomidine on photosynthesis and protein synthesis in periphyton, epipsammon and plankton communities in relation to predicted environmental concentrations. | Biofouling 20120101 |
| Capture, anesthesia, and disturbance of free-ranging brown bears (Ursus arctos) during hibernation. | PloS one 20120101 |
| Analysis of uncoupling protein 2-deficient mice upon anaesthesia and sedation revealed a role for UCP2 in locomotion. | PloS one 20120101 |
| Liquid chromatography tandem mass spectrometry for the simultaneous quantitative analysis of ketamine and medetomidine in ovine plasma. | Biomedical chromatography : BMC 20111201 |
| Clinical evaluation of total intravenous anesthesia using a combination of propofol and medetomidine following anesthesia induction with medetomidine, guaifenesin and propofol for castration in Thoroughbred horses. | The Journal of veterinary medical science 20111201 |
| Evaluation of medetomidine, ketamine and buprenorphine for neutering feral cats. | Journal of feline medicine and surgery 20111201 |
| Evaluation of two sedation protocols for use before diagnostic intra-articular anaesthesia in lame dogs. | The Journal of small animal practice 20111201 |
| A comparison of two field chemical immobilization techniques for bobcats (Lynx rufus). | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20111201 |
| Evaluation of medetomidine-alfaxalone and medetomidine-ketamine in semi-free ranging Bennett's wallabies (Macropus rufogriseus). | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20111201 |
| Evaluation of modified techniques for immobilization of wild ring-tailed lemurs (Lemur catta). | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20111201 |
| Effects of early atipamezole reversal of medetomidine-ketamine anesthesia in mice. | Journal of the American Association for Laboratory Animal Science : JAALAS 20111101 |
| Bleeding time in healthy dogs sedated with morphine and medetomidine. | The Veterinary record 20111029 |
| Minimal driving of hippocampal theta by the supramammillary nucleus during water maze learning. | Hippocampus 20111001 |
| α₂-Adrenoceptor-mediated inhibition of catecholamine release from the adrenal medulla of spontaneously hypertensive rats is preserved in the early stages of hypertension. | Basic & clinical pharmacology & toxicology 20111001 |
| Subeffective doses of nitroparacetamol (NCX-701) enhance the antinociceptive activity of the α₂-adrenoceptor agonist medetomidine. | Pharmacology, biochemistry, and behavior 20110901 |
| Physiology and mRNA expression in rainbow trout (Oncorhynchus mykiss) after long-term exposure to the new antifoulant medetomidine. | Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20110901 |
| Medetomidine/midazolam/ketamine anaesthesia in ferrets: effects on cardiorespiratory parameters and evaluation of plasma drug concentrations. | Veterinary anaesthesia and analgesia 20110901 |
| Short term pharmacological immobilization in macaque monkeys. | Veterinary anaesthesia and analgesia 20110901 |
| Comparison of the effects of racemic ketamine and S-ketamine for anesthesia in Rheem gazelles (Gazella subgutturosa marica) and Subgutturosa gazelles (Gazella subgutturosa subgutturosa). | American journal of veterinary research 20110901 |
| Effect of sedation protocol on glomerular filtration rate in cats as determined by use of quantitative renal scintigraphy. | American journal of veterinary research 20110901 |
| Comparison of carfentanil-xylazine and thiafentanil-medetomidine in electroejaculation of captive gaur (Bos gaurus). | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20110901 |
| The effect of medetomidine on the regional cerebral blood flow in dogs measured using Technetium-99m-Ethyl Cysteinate Dimer SPECT. | Research in veterinary science 20110801 |
| Cutaneous reaction after intravenous administration of medetomidine? | Veterinary anaesthesia and analgesia 20110701 |
| Effective immobilizing doses of medetomidine-ketamine in free-ranging, wild Norwegian reindeer (Rangifer tarandus tarandus). | Journal of wildlife diseases 20110701 |
| Determination of an optimal dose of medetomidine-ketamine-buprenorphine for anaesthesia in the Cape ground squirrel (Xerus inauris). | Journal of the South African Veterinary Association 20110601 |
| Sedative effects of three doses of romifidine in comparison with medetomidine in cats. | Veterinary anaesthesia and analgesia 20110501 |
| A clinical study on the effect in horses during medetomidine-isoflurane anaesthesia, of butorphanol constant rate infusion on isoflurane requirements, on cardiopulmonary function and on recovery characteristics. | Veterinary anaesthesia and analgesia 20110501 |
| Evaluation of medetomidine-ketamine and dexmedetomidine-ketamine in Chinese water deer (Hydropotes inermis). | Veterinary anaesthesia and analgesia 20110301 |
| Evaluation of the electroencephalogram in young cats. | American journal of veterinary research 20110301 |
| Comparative evaluation of halothane anaesthesia in medetomidine-butorphanol and midazolam-butorphanol premedicated water buffaloes (Bubalus bubalis). | Journal of the South African Veterinary Association 20110301 |
| Physiologic evaluation of capture and anesthesia with medetomidine-zolazepam-tiletamine in brown bears (Ursus arctos). | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20110301 |
| Biochemical variables in free-ranging white-tailed deer (Odocoileus virginianus) after chemical immobilization in clover traps or via ground-darting. | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20110301 |
| Field anesthesia of wild ring-tailed lemurs (Lemur catta) using tiletamine-zolazepam, medetomidine, and butorphanol. | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20110301 |
| Sterilisation of hybrid Galapagos tortoises (Geochelone nigra) for island restoration. Part 1: endoscopic oophorectomy of females under ketamine-medetomidine anaesthesia. | The Veterinary record 20110115 |
| Cardiovascular and respiratory safety pharmacology in Göttingen minipigs: Pharmacological characterization. | Journal of pharmacological and toxicological methods 20110101 |
| Effect of three types of mixed anesthetic agents alternate to ketamine in mice. | Experimental animals 20110101 |
| Comparison of intravenous medetomidine and medetomidine/ketamine for immobilization of free-ranging variable flying foxes (Pteropus hypomelanus). | PloS one 20110101 |
| A comparison of acepromazine-buprenorphine and medetomidine-buprenorphine for preanesthetic medication of dogs. | Journal of the American Veterinary Medical Association 20101215 |
| Effects of two fractions of inspired oxygen on lung aeration and gas exchange in cats under inhalant anaesthesia. | Veterinary anaesthesia and analgesia 20101101 |
| Evaluation of butorphanol, medetomidine and midazolam as a reversible narcotic combination in free-ranging African lions (Panthera leo). | Veterinary anaesthesia and analgesia 20101101 |
| Simultaneous fMRI and local field potential measurements during epileptic seizures in medetomidine-sedated rats using raser pulse sequence. | Magnetic resonance in medicine 20101001 |
| Effects of medetomidine-midazolam-fentanyl IV bolus injections and its reversal by specific antagonists on cardiovascular function in rabbits. | Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20101001 |
| Comparison of alpha-chloralose, medetomidine and isoflurane anesthesia for functional connectivity mapping in the rat. | Magnetic resonance imaging 20100901 |
| Comparison of anaesthetic and cardiorespiratory effects of xylazine or medetomidine in combination with tiletamine/zolazepam in pigs. | The Veterinary record 20100814 |
| Metabolic stability and determination of cytochrome P450 isoenzymes' contribution to the metabolism of medetomidine in dog liver microsomes. | Biomedical chromatography : BMC 20100801 |
| Octopamine receptors from the barnacle balanus improvisus are activated by the alpha2-adrenoceptor agonist medetomidine. | Molecular pharmacology 20100801 |
| Colour and melanophore function in rainbow trout after long term exposure to the new antifoulant medetomidine. | Chemosphere 20100801 |
| Effects of synephrine and beta-phenethylamine on human alpha-adrenoceptor subtypes. | Planta medica 20100701 |
| In vitro evaluation of fresh sperm quality in tomcats: a comparison of two collection techniques. | Theriogenology 20100701 |
| Cardiac troponin I concentrations following medetomidine-butorphanol sedation in dogs. | Veterinary anaesthesia and analgesia 20100701 |
| Anesthesia with intraperitoneal propofol, medetomidine, and fentanyl in rats. | Journal of the American Association for Laboratory Animal Science : JAALAS 20100701 |
| Sympathetic alpha(2)-adrenoceptors prevent cardiac hypertrophy and fibrosis in mice at baseline but not after chronic pressure overload. | Cardiovascular research 20100601 |
| Experience with a naphthylmedetomidine-ketamine-hyaluronidase combination in inducing immobilization in anthropoid apes. | Journal of medical primatology 20100601 |
| High field BOLD response to forepaw stimulation in the mouse. | NeuroImage 20100601 |
| Use of thiafentanil-medetomidine for the induction of anesthesia in emus (Dromaius novaehollandiae) within a wild animal park. | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20100601 |
| Evaluation of medetomidine-ketamine-butorphanol anesthesia with atipamezole-naltrexone antagonism in captive male guanacos (Lama guanicoe). | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20100601 |
| Reversible immobilization of giant otters (Pteronura brasiliensis) using medetomidine-ketamine and atipamezole. | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20100601 |
| The current functional state of local neuronal circuits controls the magnitude of a BOLD response to incoming stimuli. | NeuroImage 20100501 |
| Brief sounds evoke prolonged responses in anesthetized ferret auditory cortex. | Journal of neurophysiology 20100501 |
| Comparison of three anaesthetic protocols in Bennett's wallabies (Macropus rufogriseus). | Veterinary anaesthesia and analgesia 20100501 |
| Anaesthesia with a combination of ketamine and medetomidine in the rabbit: effect of premedication with buprenorphine. | Veterinary anaesthesia and analgesia 20100501 |
| The hemodynamic effects of medetomidine continuous rate infusions in the dog. | Veterinary anaesthesia and analgesia 20100501 |
| Effective and safe anesthesia for Yorkshire and Yucatan swine with and without cardiovascular injury and intervention. | Journal of the American Association for Laboratory Animal Science : JAALAS 20100501 |
| Intranasal naltrexone and atipamezole for reversal of white-tailed deer immobilized with carfentanil and medetomidine. | The Canadian veterinary journal = La revue veterinaire canadienne 20100501 |
| Hemodynamics and bispectral index (BIS) of dogs anesthetized with midazolam and ketamine associated with medetomidine or dexmedetomidine and submitted to ovariohysterectomy. | Acta cirurgica brasileira 20100401 |
| Comparison of cardiovascular function and quality of recovery in isoflurane-anaesthetised horses administered a constant rate infusion of lidocaine or lidocaine and medetomidine during elective surgery. | Equine veterinary journal 20100401 |
| Immobilization of red fox (Vulpes vulpes) with medetomidine-ketamine or medetomidine-midazolam and antagonism with atipamezole. | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20100301 |
| Comparison of the anesthetic effects of oral transmucosal versus injectable medetomidine in combination with tiletamine-zolazepam for immobilization of chimpanzees (Pan troglodytes). | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20100301 |
| Effects of serial anesthesia using ketamine or ketamine/medetomidine on hematology and serum biochemistry values in rhesus macaques (Macaca mulatta). | Journal of medical primatology 20100201 |
| The effect of daily repeated sedation using ketamine or ketamine combined with medetomidine on physiology and anesthetic characteristics in rhesus macaques. | Journal of medical primatology 20100201 |
| Evaluation of three immobilization combinations in the capybara (Hydrochoerus hydrochaeris). | Zoo biology 20100101 |
| The sedative effects of low-dose medetomidine and butorphanol alone and in combination intravenously in dogs. | Veterinary anaesthesia and analgesia 20100101 |
| Alfaxalone induction dose following administration of medetomidine and butorphanol in the dog. | Veterinary anaesthesia and analgesia 20100101 |
| Comparison of the effects of ketamine, ketamine-medetomidine, and ketamine-midazolam on physiologic parameters and anesthesia-induced stress in rhesus (Macaca mulatta) and cynomolgus (Macaca fascicularis) macaques. | Journal of the American Association for Laboratory Animal Science : JAALAS 20100101 |
| [Effect of dexmedetomidine on bispectral index and auditory evoked potential index during anesthesia with target controlled infusion of propofol and remifentanyl]. | Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20100101 |
| Responses in fish exposed to medetomidine, a new antifouling agent. | Marine environmental research 20100101 |
| Effects of anesthetic protocol on normal canine brain uptake of 18F-FDG assessed by PET/CT. | Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association 20100101 |
| The effect of medetomidine-ketamine anesthesia on hemodynamic parameters during hemorrhagic shock in minipigs. | Physiological research 20100101 |
| Combined cardiopulmonary assessments with implantable telemetry device in conscious freely moving cynomolgus monkeys. | Journal of pharmacological and toxicological methods 20100101 |
| Description of the type of chemical restraint used by French veterinarians to perform hip dysplasia screening radiographs. A retrospective study based on 3302 radiographs. | Veterinary and comparative orthopaedics and traumatology : V.C.O.T 20100101 |
| Hemodynamic effects of an intravenous infusion of medetomidine at six different dose regimens in isoflurane-anesthetized dogs. | Veterinary therapeutics : research in applied veterinary medicine 20100101 |
| Evaluation of two short-term anesthetic protocols in captive juvenile pronghorn (Antilocapra americana). | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20091201 |
| Partial intravenous anaesthesia in 5 horses using ketamine, lidocaine, medetomidine and halothane. | Journal of the South African Veterinary Association 20091201 |
| Atipamezole changes the antinociceptive effects of butorphanol after medetomidine-ketamine anaesthesia in rats. | Veterinary anaesthesia and analgesia 20091101 |
| Comparison of the effects of three different combinations of general anesthetics on the electroretinogram of dogs. | Documenta ophthalmologica. Advances in ophthalmology 20091001 |
| Modulation of alpha2-adrenoceptor functions by heterotrimeric Galphai protein isoforms. | The Journal of pharmacology and experimental therapeutics 20091001 |
| Antinociceptive effects of epidural buprenorphine or medetomidine, or the combination, in conscious cats. | Journal of veterinary pharmacology and therapeutics 20091001 |
| Antagonistic effects of atipamezole and yohimbine on medetomidine-induced diuresis in healthy dogs. | Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20091001 |
| Evaluation of the muscular relaxant effect of dexmedetomidine or medetomidine in cats. | Veterinary research communications 20090901 |
| A study of cardiovascular function under controlled and spontaneous ventilation in isoflurane-medetomidine anaesthetized horses. | Veterinary anaesthesia and analgesia 20090901 |
| Effects of sedative and hypnotic drug combinations on transcranial magnetic motor evoked potential, bispectral index and ARX-derived auditory evoked potential index in dogs. | Veterinary journal (London, England : 1997) 20090801 |
| The effect of the novel partial alpha2-adrenoceptor agonist naphthylmedetomidine on the basic cardiorespiratory parameters and behavior in rhesus monkeys. | Journal of medical primatology 20090801 |
| A protocol for use of medetomidine anesthesia in rats for extended studies using task-induced BOLD contrast and resting-state functional connectivity. | NeuroImage 20090715 |
| Isoflurane attenuates pulmonary interleukin-1beta and systemic tumor necrosis factor-alpha following mechanical ventilation in healthy mice. | Acta anaesthesiologica Scandinavica 20090701 |
| Bioaccumulation of the new antifoulant medetomidine in marine organisms. | Marine environmental research 20090701 |
| A comparison of the efficacy and cardiorespiratory effects of four medetomidine-based anaesthetic protocols in the red fox (Vulpes vulpes). | Veterinary anaesthesia and analgesia 20090701 |
| Evaluation of the anaesthetic effects of medetomidine and ketamine in rats and their reversal with atipamezole. | Veterinary anaesthesia and analgesia 20090701 |
| Incorrect comments regarding the use of butorphanol-medetomidine as a premedicant in cats. | The Journal of small animal practice 20090701 |
| Reversible immobilization of free-ranging Svalbard reindeer (Rangifer tarandus platyrhynchus) with medetomidine-ketamine and atipamezole. | Journal of wildlife diseases 20090701 |
| Diuretic effects of medetomidine compared with xylazine in healthy dogs. | Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20090701 |
| Evaluation of the effects of naloxone on recovery time and quality after ketamine-medetomidine-butorphanol anesthesia in servals (Leptailurus serval). | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20090601 |
| The effects of different anesthetic agents on short electroretinography protocol in dogs. | The Journal of veterinary medical science 20090601 |
| Visual and quantitative electroencephalographic analysis of healthy young and adult cats under medetomidine sedation. | Veterinary journal (London, England : 1997) 20090501 |
| Seizures during medetomindine sedation and local anaesthesia in two dogs undergoing skin biopsy. | Australian veterinary journal 20090501 |
| Urethral obstruction by seminal coagulum is associated with medetomidine-ketamine anesthesia in male mice on C57BL/6J and mixed genetic backgrounds. | Journal of the American Association for Laboratory Animal Science : JAALAS 20090501 |
| Butorphanol-azaperone-medetomidine for immobilization of captive white-tailed deer. | Journal of wildlife diseases 20090401 |
| Butorphanol, azaperone, and medetomidine anesthesia in free-ranging white-tailed deer (Odocoileus virginianus) using radiotransmitter darts. | Journal of wildlife diseases 20090401 |
| The use of lingual venous blood to determine the acid-base and blood-gas status of dogs under anesthesia. | Veterinary anaesthesia and analgesia 20090301 |
| The effect of the novel alpha-2-adrenoceptor agonist naphthylmedetomidine on pulse rate, arterial blood pressure and sedation in rabbits. | Veterinary anaesthesia and analgesia 20090301 |
| Effects of medetomidine, L-methadone, and their combination on arterial blood gases in dogs. | Veterinary anaesthesia and analgesia 20090301 |
| Investigating medetomidine-buprenorphine as preanaesthetic medication in cats. | The Journal of small animal practice 20090201 |
| Behavioural and cardiorespiratory effects of a constant rate infusion of medetomidine and morphine for sedation during standing laparoscopy in horses. | Equine veterinary journal 20090201 |
| Induction of anaesthesia in wild rabbits using a new alfaxalone formulation. | The Veterinary record 20090124 |
| Intraperitoneal anaesthesia with propofol, medetomidine and fentanyl in mice. | Laboratory animals 20090101 |
| Effect of bupivacaine on epidural analgesia produced by xylazine or medetomidine in buffaloes (Bubalus bubalis). | Veterinary anaesthesia and analgesia 20090101 |
| Evaluation of medetomidine-midazolam-atropine (MeMiA) anesthesia maintained with propofol infusion in New Zealand White rabbits. | Polish journal of veterinary sciences 20090101 |
| Determination of a sedative protocol for use in California sea lions (Zalophus californianus) with neurologic abnormalities undergoing electroencephalographic examination. | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20081201 |
| Field anesthesia of golden jackals (Canis aureus) with the use of medetomidine-ketamine or medetomidine-midazolam with atipamezole reversal. | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20081201 |
| Anesthetic and cardiopulmonary effects of intramuscular morphine, medetomidine, ketamine injection in dogs. | Veterinary anaesthesia and analgesia 20081101 |
| Effects of premedication with tiletamine/zolazepam/medetomidine during general anesthesia using sevoflurane/fentanyl in swine undergoing pancreas transplantation. | Transplantation proceedings 20081101 |
| Efficacy and safety of five injectable anesthetic regimens for chronic blood collection from the anterior vena cava of Guinea pigs. | Journal of the American Association for Laboratory Animal Science : JAALAS 20081101 |
| Evaluation of the efficacy and safety for use of two sedation and analgesia protocols to facilitate assisted ventilation of healthy dogs. | American journal of veterinary research 20081001 |
| Immobilization of free-ranging Hoffmann's two-toed and brown-throated three-toed sloths using ketamine and medetomidine: a comparison of physiologic parameters. | Journal of wildlife diseases 20081001 |
| The effects of medetomidine on the action of vecuronium in dogs anaesthetized with halothane and nitrous oxide. | Veterinary anaesthesia and analgesia 20080901 |
| Evaluation of intramuscular butorphanol, azaperone, and medetomidine and nasal oxygen insufflation for the chemical immobilization of white-tailed deer, Odocoileus virginianus. | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20080901 |
| Regio- and stereospecific N-glucuronidation of medetomidine: the differences between UDP glucuronosyltransferase (UGT) 1A4 and UGT2B10 account for the complex kinetics of human liver microsomes. | Drug metabolism and disposition: the biological fate of chemicals 20080801 |
| Differences in hepatic cytochrome P450 activity correlate with the strain-specific biotransformation of medetomidine in AX/JU and IIIVO/JU inbred rabbits. | Journal of veterinary pharmacology and therapeutics 20080801 |
| Immobilization of black bears (Ursus americanus) with a combination of butorphanol, azaperone, and medetomidine. | Journal of wildlife diseases 20080701 |
| Effects of medetomidine and midazolam alone or in combination on the metabolic and neurohormonal responses in healthy cats. | Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20080701 |
| Effects of a peripheral alpha2 adrenergic-receptor antagonist on the hemodynamic changes induced by medetomidine administration in conscious dogs. | American journal of veterinary research 20080601 |
| The efficacy of orally dosed ketamine and ketamine/medetomidine compared with intramuscular ketamine in rhesus macaques (Macaca mulatta) and the effects of dosing route on haematological stress markers. | Journal of medical primatology 20080601 |
| Caesarian section and neonatal care in the aardvark (Orycteropus afer). | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20080601 |
| Inhibition of opioid release in the rat spinal cord by alpha2C adrenergic receptors. | Neuropharmacology 20080501 |
| Cardiopulmonary effects of anesthetic induction with thiopental, propofol, or a combination of ketamine hydrochloride and diazepam in dogs sedated with a combination of medetomidine and hydromorphone. | American journal of veterinary research 20080501 |
| Neurohormonal and metabolic effects of medetomidine compared with xylazine in healthy cats. | Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20080401 |
| Quality and in vitro fertilizing ability of cryopreserved cat spermatozoa obtained by urethral catheterization after medetomidine administration. | Theriogenology 20080301 |
| A comparison of ketamine-midazolam and ketamine-medetomidine combinations for induction of anaesthesia in rabbits. | Veterinary anaesthesia and analgesia 20080301 |
| Sedative and cardiopulmonary effects of medetomidine hydrochloride and xylazine hydrochloride and their reversal with atipamezole hydrochloride in calves. | American journal of veterinary research 20080301 |
| Effect of medetomidine infusion on the anaesthetic requirements of desflurane in dogs. | Research in veterinary science 20080201 |
| Antagonistic effects of atipamezole, flumazenil and 4-aminopyridine against anaesthesia with medetomidine, midazolam and ketamine combination in cats. | Journal of feline medicine and surgery 20080201 |
| Effects of medetomidine on Doppler variables of major abdominal arteries in normal dogs. | Veterinary research communications 20080201 |
| Reversible medetomidine/ketamine anesthesia in captive capuchin monkeys (Cebus apella). | Journal of medical primatology 20080201 |
| Sedative and cardiorespiratory effects of three doses of romifidine in comparison with medetomidine in five cats. | The Veterinary record 20080119 |
| The effects of medetomidine on radial nerve blockade with mepivacaine in dogs. | Veterinary anaesthesia and analgesia 20080101 |
| Effects of medetomidine on hepatic EROD activity in three species of fish. | Ecotoxicology and environmental safety 20080101 |
| BOLD study of stimulation-induced neural activity and resting-state connectivity in medetomidine-sedated rat. | NeuroImage 20080101 |
| Capture and medetomidine-ketamine anesthesia of free-ranging wolverines (Gulo gulo). | Journal of wildlife diseases 20080101 |
| [Clinical evaluation of three medetomidine--midazolam--ketamine combinations for neutering of ferrets (Mustela putorius furo)]. | Berliner und Munchener tierarztliche Wochenschrift 20080101 |
| Selective antiaggressive effect of an alpha-2 adrenoceptor agonist naphthylmedetomidine in mice. | Aggressive behavior 20080101 |
| Changes in minimal alveolar concentration of isoflurane following treatment with medetomidine and tiletamine/zolazepam, epidural morphine or systemic buprenorphine in pigs. | Laboratory animals 20080101 |
| The effects of medetomidine hydrochloride on the electroretinogram of normal dogs. | Veterinary ophthalmology 20080101 |
| Evaluation of the anaesthetic effects of combinations of ketamine, medetomidine, romifidine and butorphanol in European badgers (Meles meles). | Veterinary anaesthesia and analgesia 20071101 |
| Partial antagonization of midazolam-medetomidine-ketamine in cats--atipamezole versus combined atipamezole and flumazenil. | Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20071101 |
| Comparison of subcutaneous and intramuscular ketamine-medetomidine with and without reversal by atipamezole in Dutch belted rabbits (Oryctolagus cuniculus). | Journal of the American Association for Laboratory Animal Science : JAALAS 20071101 |
| Clinicophysiological effects of spinally administered ketamine and its combination with xylazine and medetomidine in healthy goats. | Veterinary research communications 20071001 |
| A comparative clinical study of three different dosages of intramuscular midazolam-medetomidine-ketamine immobilization in cats. | Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20071001 |
| Effects of ketamine or medetomidine administration on quality of electroejaculated sperm and on sperm flow in the domestic cat. | Theriogenology 20070915 |
| Medetomidine as a candidate antifoulant: sublethal effects on juvenile turbot (Psetta maxima L.). | Aquatic toxicology (Amsterdam, Netherlands) 20070720 |
| Field anaesthesia of leatherback sea turtles (Dermochelys coriacea). | The Veterinary record 20070707 |
| A clinical comparison of two anaesthetic protocols using lidocaine or medetomidine in horses. | Veterinary anaesthesia and analgesia 20070701 |
| Differences in response to anaesthetics and analgesics between inbred rat strains. | Laboratory animals 20070701 |
| Evaluation of a medetomidine-midazolam combination for immobilizing and sedating Japanese monkeys (Macaca fuscata). | Journal of the American Association for Laboratory Animal Science : JAALAS 20070701 |
| Survey of utilization of medetomidine and atipamezole in private veterinary practice in Quebec in 2002. | The Canadian veterinary journal = La revue veterinaire canadienne 20070701 |
| Evaluation of the clinical efficacy and safety of intramuscular and intravenous doses of dexmedetomidine and medetomidine in dogs and their reversal with atipamezole. | The Veterinary record 20070630 |
| Peri-operative body temperatures in isoflurane-anaesthetized rabbits following ketamine-midazolam or ketamine-medetomidine. | Veterinary anaesthesia and analgesia 20070501 |
| Sevoflurane anaesthesia in Iberian lynx (Lynx pardinus). | The Veterinary record 20070428 |
| Anaesthetic and cardiopulmonary effects of intramuscular morphine, medetomidine and ketamine administered to telemetered cats. | Journal of feline medicine and surgery 20070401 |
| Impact of sedation method on the diagnosis of hip and elbow dysplasia in Swedish dogs. | Preventive veterinary medicine 20070317 |
| Evaluation of cardiovascular effects of total intravenous anesthesia with propofol or a combination of ketamine-medetomidine-propofol in horses. | American journal of veterinary research 20070201 |
| In vivo evaluation of alpha(2)-adrenoceptors in cats with idiopathic cystitis. | American journal of veterinary research 20070201 |
| Total intravenous anaesthesia with propofol or propofol/ketamine in spontaneously breathing dogs premedicated with medetomidine. | The Veterinary record 20070120 |
| Post-anesthetic hyperthermia in cats. | Veterinary anaesthesia and analgesia 20070101 |
| Anesthetic and cardiopulmonary effects of total intravenous anesthesia using a midazolam, ketamine and medetomidine drug combination in horses. | The Journal of veterinary medical science 20070101 |
| Oxygenation in medetomidine-sedated dogs with and without 100% oxygen insufflation. | Veterinary therapeutics : research in applied veterinary medicine 20070101 |
| Effects of tribromoethanol-medetomidine combination on cycling and ovariectomized Sprague-Dawley rats. | Lab animal 20070101 |
| A cardiovascular monitoring system used in conscious cynomolgus monkeys for regulatory safety pharmacology. Part 2: Pharmacological validation. | Journal of pharmacological and toxicological methods 20070101 |
| Comparison of anesthetic and cardiorespiratory effects of tiletamine-zolazepam-butorphanol and tiletamine-zolazepam-butorphanol-medetomidine in dogs. | Veterinary therapeutics : research in applied veterinary medicine 20070101 |
| Continuous infusion in adult females dogs submitted to ovariohysterectomy with midazolam-xylazine and/or medetomidine pre-treated with methotrimeprazine and buprenorphine. | Acta cirurgica brasileira 20070101 |
| A comparison of anesthetic and cardiorespiratory effects of tiletamine-zolazepam-butorphanol and tiletamine-zolazepam-butorphanol- medetomidine in cats. | Veterinary therapeutics : research in applied veterinary medicine 20070101 |
| Effects of a candidate antifouling compound (medetomidine) on pheromone induced mate search in the amphipod Corophium volutator. | Marine pollution bulletin 20061201 |
| Effects of carprofen on renal function during medetomidine-propofol-isoflurane anesthesia in dogs. | American journal of veterinary research 20061201 |
| Anesthesia of male axis deer (Axis axis): evaluation of thiafentanil, medetomidine, and ketamine versus medetomidine and ketamine. | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20061201 |
| Reversible anesthesia in wild marine otters (Lontra felina) using ketamine and medetomidine. | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20061201 |
| Reversible anesthesia of Southeast Asian primates with medetomidine, zolazepam, and tiletamine. | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20061201 |
| Cardiopulmonary effects of medetomidine or midazolam in combination with ketamine or tiletamine/zolazepam for the immobilisation of captive cheetahs (Acinonyx jubatus). | Journal of the South African Veterinary Association 20061201 |
| Complexation chemistry for tuning release from polymer coatings. | The journal of physical chemistry. B 20061102 |
| Tethered yohimbine analogs as selective human alpha2C-adrenergic receptor ligands. | The Journal of pharmacology and experimental therapeutics 20061101 |
| GLC756 decreases TNF-alpha via an alpha2 and beta2 adrenoceptor related mechanism. | Experimental eye research 20061101 |
| Comparison of romifidine and medetomidine pre-medication in propofol-isoflurane anaesthetised dogs. | Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20061101 |
| Effects of medetomidine, a novel antifouling agent, on the burrowing bivalve Abra nitida (Müller). | Chemosphere 20061001 |
| Cardiorespiratory effects of desflurane in dogs given romifidine or medetomidine before induction of anesthesia with propofol. | Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20061001 |
| Effect of four sedative and anesthetic protocols on quantitative thyroid scintigraphy in euthyroid cats. | American journal of veterinary research 20060801 |
| Evaluation of the clinical efficacy and safety of dexmedetomidine or medetomidine in cats and their reversal with atipamezole. | Veterinary anaesthesia and analgesia 20060701 |
| Cerebral state monitoring in Beagle dogs sedated with medetomidine. | Veterinary anaesthesia and analgesia 20060701 |
| Dexmedetomidine or medetomidine premedication before propofol-desflurane anaesthesia in dogs. | Journal of veterinary pharmacology and therapeutics 20060601 |
| Effects of xylazine, medetomidine, detomidine, and diazepam on sedation, heart and respiratory rates, and cloacal temperature in rock partridges (Alectoris graeca). | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20060601 |
| Anesthesia of captive African wild dogs (Lycaon pictus) using a medetomidine-ketamine-atropine combination. | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20060601 |
| Effect of medetomidine on respiration and minimum alveolar concentration in halothane- and isoflurane-anesthetized dogs. | American journal of veterinary research 20060501 |
| Evaluation of total intravenous anesthesia with propofol or ketamine-medetomidine-propofol combination in horses. | Journal of the American Veterinary Medical Association 20060415 |
| Reversible immobilization of free-ranging African lions (Panthera leo) with medetomidine-tiletamine-zolazepam and atipamezole. | Journal of wildlife diseases 20060401 |
| Evaluation of medetomidine/ketamine for short-term immobilization of variable flying foxes (Pteropus hypomelanus). | Journal of wildlife diseases 20060401 |
| The influence of the time course of inflammation and spinalization on the antinociceptive activity of the alpha2-adrenoceptor agonist medetomidine. | European journal of pharmacology 20060217 |
| A fully noninvasive and robust experimental protocol for longitudinal fMRI studies in the rat. | NeuroImage 20060215 |
| Comparative pharmacokinetics of medetomidine enantiomers in goats and sheep during sevoflurane anaesthesia. | Journal of veterinary pharmacology and therapeutics 20060201 |
| Effects of intravenous diazepam or microdose medetomidine on propofol-induced sedation in dogs. | Journal of the American Animal Hospital Association 20060101 |
| Effects of medetomidine and medetomidine-butorphanol combination on Schirmer tear test 1 readings in dogs. | Veterinary ophthalmology 20060101 |
| Comparison of two pre-anaesthetic medetomidine doses in isoflurane anaesthetized sheep. | Veterinary anaesthesia and analgesia 20060101 |
| Successful protocol of anaesthesia for measuring transepithelial nasal potential difference in spontaneously breathing mice. | Laboratory animals 20060101 |
| Evaluation of sedation on electroencephalographic spectral edge frequency 95 in dogs sedated by acupuncture at GV20 or Yintang and sedative combination. | Acupuncture & electro-therapeutics research 20060101 |
| Reversible anaesthesia of free-ranging lions (Panthera leo) in Zimbabwe. | Journal of the South African Veterinary Association 20051201 |
| Total intravenous anaesthesia in horses using medetomidine and propofol. | Veterinary anaesthesia and analgesia 20051101 |
| The use and assessment of ketamine-medetomidine-butorphanol combinations for field anaesthesia in wild European badgers (Meles meles). | Veterinary anaesthesia and analgesia 20051101 |
| Romifidine or medetomidine premedication before propofol-sevoflurane anaesthesia in dogs. | Journal of veterinary pharmacology and therapeutics 20051001 |
| Comparative study of three intramuscular anaesthetic combinations (medetomidine/ketamine, medetomidine/fentanyl/midazolam and xylazine/ketamine) in rabbits. | Veterinary anaesthesia and analgesia 20050901 |
| Assessment of ketamine and medetomidine anaesthesia in the domestic rabbit. | Veterinary anaesthesia and analgesia 20050901 |
| Determination of acepromazine, ketamine, medetomidine, and xylazine in serum: multi-residue screening by liquid chromatography-mass spectrometry. | Journal of analytical toxicology 20050901 |
| Acute aortic rupture in a dog with spirocercosis following the administration of medetomidine. | Journal of the South African Veterinary Association 20050901 |
| The use of a medetomidine, butorphanol and atropine combination to enable blood sampling in young pigs. | New Zealand veterinary journal 20050801 |
| Evaluation of the cardiovascular effects of an anaesthetic protocol for immobilization and anaesthesia in grey wolves (Canis lupus L, 1758). | Veterinary research communications 20050801 |
| Comparison of xylazine and medetomidine as premedicants for cats being anaesthetised with propofol-sevoflurane. | The Veterinary record 20050730 |
| Yohimbine disrupts prepulse inhibition in rats via action at 5-HT1A receptors, not alpha2-adrenoceptors. | Psychopharmacology 20050701 |
| Cardiopulmonary effects of fentanyl in conscious dogs and dogs sedated with a continuous rate infusion of medetomidine. | American journal of veterinary research 20050701 |
| Evaluation of two combinations of Domitor, Zoletil 100, and Euthatal to obtain long-term nonrecovery anesthesia in Sprague-Dawley rats. | Comparative medicine 20050601 |
| Medetomidine and dexmedetomidine: a review of cardiovascular effects and antinociceptive properties in the dog. | Veterinary anaesthesia and analgesia 20050501 |
| Effect of medetomidine and its antagonism with atipamezole on stress-related hormones, metabolites, physiologic responses, sedation, and mechanical threshold in goats. | Veterinary anaesthesia and analgesia 20050501 |
| Renal effects of medetomidine in isoflurane-anesthetized dogs with special reference to its diuretic action. | The Journal of veterinary medical science 20050501 |
| Anesthetic and cardiovascular effects of balanced anesthesia using constant rate infusion of midazolam-ketamine-medetomidine with inhalation of oxygen-sevoflurane (MKM-OS anesthesia) in horses. | The Journal of veterinary medical science 20050401 |
| Use of medetomidine-ketamine and atipamezole for reversible immobilization of free-ranging hog deer (Axis porcinus) captured in drive nets. | Journal of wildlife diseases 20050401 |
| Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking activity. | Journal of medicinal chemistry 20050324 |
| Results of 24-hour ambulatory electrocardiography in dogs undergoing ovariohysterectomy following premedication with medetomidine or acepromazine. | Journal of the American Veterinary Medical Association 20050301 |
| Influence of medetomidine on stress-related neurohormonal and metabolic effects caused by butorphanol, fentanyl, and ketamine administration in dogs. | American journal of veterinary research 20050301 |
| Anaesthesia of nyala (Tragelaphus angasi) with a combination of thiafentanil (A3080), medetomidine and ketamine. | Journal of the South African Veterinary Association 20050301 |
| Ketamine-medetomidine anesthesia with atipamezole reversal: practical anesthesia for rodents under field conditions. | Lab animal 20050201 |
| Preliminary comparison of four anaesthetic techniques in badgers (Meles meles). | Veterinary anaesthesia and analgesia 20050101 |
| Tribromoethanol-medetomidine combination provides a safe and reversible anesthetic effect in Sprague-Dawley rats. | Contemporary topics in laboratory animal science 20050101 |
| Medetomidine with ketamine and bupivacaine for epidural analgesia in buffaloes. | Veterinary research communications 20050101 |
| Sublethal effects of a new antifouling candidate on lumpfish (Cyclopterus lumpus L.) and Atlantic cod (Gadus morhua L.) larvae. | Biofouling 20050101 |
| Four preanesthetic oral sedation protocols for rhesus macaques (Macaca mulatta). | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20041201 |
| Reversal of medetomidine-ketamine combination anesthesia in rabbits by atipamezole. | Experimental animals 20041001 |
| Immobilization of Chacoan peccaries (Catagonus wagneri) using medetomidine, Telazol, and ketamine. | Journal of wildlife diseases 20041001 |
| Xylazine-midazolam-ketamine versus medetomidine-midazolam-ketamine anesthesia in captive Siberian tigers (Panthera tigris altaica). | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20040901 |
| Evaluation of the effects of premedication on gastroduodenoscopy in cats. | Journal of the American Veterinary Medical Association 20040815 |
| Intramuscular anesthesia of bonito and Pacific mackerel with ketamine and medetomidine and reversal of anesthesia with atipamezole. | Journal of the American Veterinary Medical Association 20040801 |
| Comparative cardiovascular, analgesic, and sedative effects of medetomidine, medetomidine-hydromorphone, and medetomidine-butorphanol in dogs. | American journal of veterinary research 20040701 |
| In-vitro contraction of the equine aortic valve. | The Journal of heart valve disease 20040701 |
| Effect of medetomidine on breathing and inspiratory neuromuscular drive in conscious dogs. | American journal of veterinary research 20040601 |
| Comparison of medetomidine-ketamine and dexmedetomidine-ketamine anesthesia in golden-headed lion tamarins. | The Canadian veterinary journal = La revue veterinaire canadienne 20040601 |
| Anaesthesia with midazolam/medetomidine/fentanyl in chinchillas (Chinchilla lanigera) compared to anaesthesia with xylazine/ketamine and medetomidine/ketamine. | Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20040601 |
| The effect of tiletamine/zolazepam (Zoletile) combination with xylazine or medetomidine on electroencephalograms in dogs. | The Journal of veterinary medical science 20040501 |
| Impact of polymer surface affinity of novel antifouling agents. | Biotechnology and bioengineering 20040405 |
| The effect of four anesthetic protocols on splenic size in dogs. | Veterinary anaesthesia and analgesia 20040401 |
| Cardiopulmonary effects of medetomidine, oxymorphone, or butorphanol in selegiline-treated dogs. | Veterinary anaesthesia and analgesia 20040401 |
| Experimental comparison of ketamine with a combination of ketamine, butorphanol and medetomidine for general anaesthesia of the Eurasian badger (Meles meles L.). | Veterinary journal (London, England : 1997) 20040301 |
| Reversible anesthesia of captive California sea lions (Zalophus californianus) with medetomidine, midazolam, butorphanol, and isoflurane. | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20040301 |
| Immobilisation of impala (Aepyceros melampus) with a ketamine hydrochloride/medetomidine hydrochloride combination, and reversal with atipamezole hydrochloride. | Journal of the South African Veterinary Association 20040301 |
| Medetomidine analogs as selective agonists for the human alpha2-adrenoceptors. | Biochemical pharmacology 20040101 |
| Pentobarbital versus medetomidine-ketamine-fentanyl anaesthesia: effects on haemodynamics and the incidence of ischaemia-induced ventricular fibrillation in swine. | Laboratory animals 20040101 |
| A comparison of xylazine and medetomidine in an anesthetic combination in New Zealand White Rabbits. | Contemporary topics in laboratory animal science 20040101 |
| All three alpha2-adrenoceptor types serve as autoreceptors in postganglionic sympathetic neurons. | Naunyn-Schmiedeberg's archives of pharmacology 20031201 |
| Medetomidine-ketamine-butorphanol anesthetic combinations in binturongs (Arctictis binturong). | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20031201 |
| The effect of intrathecal medetomidine on small bowel transit in the rat. | European journal of anaesthesiology 20031101 |
| A review of the physiological effects of alpha2-agonists related to the clinical use of medetomidine in small animal practice. | The Canadian veterinary journal = La revue veterinaire canadienne 20031101 |
| Effects of midazolam-butorphanol, acepromazine-butorphanol and medetomidine on an induction dose of propofol and their compatibility in dogs. | The Journal of veterinary medical science 20031001 |
| Influence of yohimbine and atipamezole on haemodynamics and ECG after lumbosacral subarachnoid administration of medetomidine in goats. | Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20031001 |
| Comparison of etorphine-detomidine and medetomidine-ketamine anesthesia in captive addax (Addax nasomaculatus). | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20030901 |
| Anesthetic induction of captive tigers (Panthera tigris) using a medetomidine-ketamine combination. | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20030901 |
| Pharmacokinetics and sedative effects of intramuscular medetomidine in domestic sheep. | Journal of veterinary pharmacology and therapeutics 20030801 |
| Comparison of ketamine versus combination of ketamine and medetomidine in injectable anesthetic protocols: chemical immobilization in macaques and tissue reaction in rats. | Contemporary topics in laboratory animal science 20030701 |
| Evaluation of three combinations of anesthetics for use in free-ranging alpine marmots (Marmota marmota). | Journal of wildlife diseases 20030701 |
| Evaluation of propofol and medetomidine-ketamine for short-term immobilization of Gulf of Mexico sturgeon (Acipenser oxyrinchus de soti). | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20030601 |
| Comparison of the efficacy and cardiorespiratory effects of medetomidine-based anesthetic protocols in ring-tailed lemurs (Lemur catta). | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20030601 |
| Immobilization of sun bears (Helarctos malayanus) with medetomidine-zolazepam-tiletamine. | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20030601 |
| [Domitor not to used in collies?]. | Tijdschrift voor diergeneeskunde 20030515 |
| Effects of anaesthesia and manual restraint on the plasma concentrations of pituitary and adrenocortical hormones in ferrets. | The Veterinary record 20030510 |
| Medetomidine-ketamine anaesthesia induction followed by medetomidine-propofol in ponies: infusion rates and cardiopulmonary side effects. | Equine veterinary journal 20030501 |
| Immobilization of free-ranging European mink (Mustela lutreola) an polecat (Mustela putorius) with medetomidine-ketamine and reversal by atipamezole. | Journal of wildlife diseases 20030401 |
| Strain differences in response to propofol, ketamine and medetomidine in rabbits. | The Veterinary record 20030308 |
| Effect of medetomidine administration on bispectral index measurements in dogs during anesthesia with isoflurane. | American journal of veterinary research 20030301 |
| Comparison of the cardiorespiratory effects of medetomidine-butorphanol-ketamine and medetomidine-butorphanol-midazolam in patas monkeys (Erythrocebus patas). | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20030301 |
| Postoperative analgesia in dogs receiving epidural morphine plus medetomidine. | Journal of veterinary pharmacology and therapeutics 20030201 |
| Isoflurane to prolong medetomidine/ ketamine anaesthesia in six adult female chimpanzees (Pan troglodytes). | The Veterinary record 20030104 |
| The antagonistic effects of atipamezole and yohimbine on stress-related neurohormonal and metabolic responses induced by medetomidine in dogs. | Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20030101 |
| Effect of dorsal hip loading, sedation, and general anesthesia on the dorsolateral subluxation score in dogs. | Veterinary surgery : VS 20030101 |
| Medetomidine a novel immobilizing agent for the elephant (Elephas maximus). | Research in veterinary science 20021201 |
| Effects of medetomidine-midazolam, acepromazine-butorphanol, and midazolam-butorphanol on induction dose of thiopental and propofol and on cardiopulmonary changes in dogs. | American journal of veterinary research 20021201 |
| Surgical implantation of radio transmitters in arctic foxes (Alopex lagopus) on Svalbard, Norway. | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20021201 |
| Medetomidine-ketamine in reindeer (Rangifer tarandus tarandus): effective immobilization by hand- and dart-administered injection. | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20021201 |
| Doppler echocardiographic effects of medetomidine on dynamic left ventricular outflow tract obstruction in cats. | Journal of the American Veterinary Medical Association 20021101 |
| Clinical comparison of xylazine and medetomidine for premedication of horses. | Journal of the American Veterinary Medical Association 20021015 |
| Infusion of guaifenesin, ketamine, and medetomidine in combination with inhalation of sevoflurane versus inhalation of sevoflurane alone for anesthesia of horses. | Journal of the American Veterinary Medical Association 20021015 |
| Medetomidine, ketamine, and sevoflurane for anesthesia of injured loggerhead sea turtles: 13 cases (1996-2000). | Journal of the American Veterinary Medical Association 20021001 |
| The cardiovascular and respiratory effects of medetomidine and thiopentone anaesthesia in dogs breathing at an altitude of 1486 m. | Journal of the South African Veterinary Association 20020901 |
| Effect of medetomidine-butorphanol-ketamine anaesthesia and atipamezole on heart and respiratory rate and cloacal temperature of domestic pigeons. | Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20020801 |
| Effects of medetomidine-midazolam, midazolambutorphanol, or acepromazine-butorphanol as premedicants for mask induction of anesthesia with sevoflurane in dogs. | American journal of veterinary research 20020701 |
| Evaluation of the perioperative stress response in dogs administered medetomidine or acepromazine as part of the preanesthetic medication. | American journal of veterinary research 20020701 |
| Reliability of goniometry in Labrador Retrievers. | American journal of veterinary research 20020701 |
| Hemodynamics of anesthetized ventilated mouse models: aspects of anesthetics, fluid support, and strain. | American journal of physiology. Heart and circulatory physiology 20020601 |
| Cardiorespiratory effects of medetomidine-butorphanol, medetomidine-butorphanol-diazepam, and medetomidine-butorphanol-ketamine in captive red wolves (Canis rufus). | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20020601 |
| Cardiopulmonary effects of a medetomidine-ketamine combination administered intravenously in gopher tortoises. | Journal of the American Veterinary Medical Association 20020515 |
| Quantitative electroencephalography of medetomidine, medetomidine-midazolam and medetomidine-midazolam-butorphanol in dogs. | Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20020501 |
| Anesthesia of boma-captured Lichtenstein's hartebeest (Sigmoceros lichtensteinii) with a combination of thiafentanil, medetomidine, and ketamine. | Journal of wildlife diseases 20020401 |
| N-Glucuronidation of some 4-arylalkyl-1H-imidazoles by rat, dog, and human liver microsomes. | Drug metabolism and disposition: the biological fate of chemicals 20020301 |
| Infusion of alpha-2-adrenergic agents into the paraventricular and arcuate nuclei of the hypothalamus in the Siberian hamster: opposing effects on basal prolactin. | Neuroendocrinology 20020301 |
| Use of medetomidine for capture and restraint of cassowaries (Casuarius casuaris). | Australian veterinary journal 20020301 |
| Evaluation of medetomidine-ketamine anesthesia with atipamezole reversal in American alligators (Alligator mississippiensis). | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20020301 |
| Chemical restraint of fishers (Martes pennanti) with ketamine and medetomidine-ketamine. | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20020301 |
| Some factors influencing the level of clinical sedation induced by medetomidine in rabbits. | Journal of veterinary pharmacology and therapeutics 20020201 |
| Neurohormonal and metabolic effects of medetomidine compared with xylazine in beagle dogs. | Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20020101 |
| Postoperative pain control in cats: clinical trials with medetomidine and butorphanol. | Veterinary surgery : VS 20020101 |
| [Medetomidine-butorphanol combination anesthesia in the dog]. | Schweizer Archiv fur Tierheilkunde 20011201 |
| Cardiopulmonary evaluation of the use of medetomidine hydrochloride in cats. | American journal of veterinary research 20011101 |
| Cardiopulmonary effects of three different anaesthesia protocols in cats. | The Veterinary quarterly 20011101 |
| Effect of medetomidine on electroencephalography and use of a quantitative electroencephalograph for evaluating sedation levels in dogs. | Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20011101 |
| Clinical comparison of preanaesthetic intramuscular medetomidine and dexmedetomidine in domestic sheep. | DTW. Deutsche tierarztliche Wochenschrift 20011001 |
| Cardiopulmonary effects of prolonged anesthesia via propofol-medetomidine infusion in ponies. | American journal of veterinary research 20010901 |
| Effects of medetomidine and buprenorphine administered for sedation in dogs. | The Journal of small animal practice 20010901 |
| Procedure for successful interspecific embryo transfer from mouflon (Ovis gmelini musimon) to Spanish Merino sheep (Ovis aries). | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20010901 |
| Comparison of medetomidine and dexmedetomidine as premedicants in dogs undergoing propofol-isoflurane anesthesia. | American journal of veterinary research 20010701 |
| Reversible immobilization of eurasian otters with a combination of ketamine and medetomidine. | Journal of wildlife diseases 20010701 |
| Use of medetomidine-zolazepam-tiletamine with and without atipamezole reversal to immobilize captive California sea lions. | Journal of wildlife diseases 20010701 |
| Anaesthesia of gemsbok (Oryx gazella) with a combination of A3080, medetomidine and ketamine. | Journal of the South African Veterinary Association 20010601 |
| Cardiopulmonary assessment of medetomidine, ketamine, and butorphanol anesthesia in captive Thomson's gazelles (Gazella thomsoni). | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20010601 |
| High-performance liquid chromatographic method combining radiochemical and ultraviolet detection for determination of low activities of uridine 5'-diphosphate-glucuronosyltransferase. | Analytical biochemistry 20010515 |
| Modulation of ligand responses by coupling of alpha(2A)-adrenoceptors to diverse G(alpha)-proteins. | Biochemical pharmacology 20010501 |
| Medetomidine-ketamine anesthesia in red-eared slider turtles (Trachemys scripta elegans). | Contemporary topics in laboratory animal science 20010501 |
| Comparison of medetomidine and dexmedetomidine as premedication in isoflurane anaesthesia for orthopaedic surgery in domestic sheep. | Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20010501 |
| Acid-base status and blood gas arterial values in free-ranging sika deer hinds immobilized with medetomidine and ketamine. | Journal of wildlife diseases 20010401 |
| Infusion of a combination of propofol and medetomidine for long-term anesthesia in ponies. | American journal of veterinary research 20010401 |
| Sedative, analgesic, and cardiovascular effects of levomedetomidine alone and in combination with dexmedetomidine in dogs. | American journal of veterinary research 20010401 |
| Minimal alveolar concentration of desflurane in combination with an infusion of medetomidine for the anaesthesia of ponies. | The Veterinary record 20010303 |
| Clinical evaluation of established optimal immobilizing doses of medetomidine-ketamine in captive reindeer (Rangifer tarandus tarandus). | American journal of veterinary research 20010301 |
| The effects of topical tropicamide and systemic medetomidine, followed by atipamezole reversal, on pupil size and intraocular pressure in normal dogs. | Veterinary ophthalmology 20010301 |
| Anaesthesia of roan antelope (Hippotragus equinus) with a combination of A3080, medetomidine and ketamine. | Journal of the South African Veterinary Association 20010301 |
| Alpha2-adrenoceptors modulating neuronal serotonin release: a study in alpha2-adrenoceptor subtype-deficient mice. | British journal of pharmacology 20010201 |
| Results of cystometry and urethral pressure profilometry in dogs sedated with medetomidine or xylazine. | American journal of veterinary research 20010201 |
| Use of medetomidine and ketamine for immobilization of free-ranging giraffes. | Journal of the American Veterinary Medical Association 20010115 |
| Effects of preemptive atropine administration on incidence of medetomidine-induced bradycardia in dogs. | Journal of the American Veterinary Medical Association 20010101 |
| Determination of optimal immobilizing doses of a medetomidine hydrochloride and ketamine hydrochloride combination in captive reindeer. | American journal of veterinary research 20010101 |
| Anesthetic effects of ketamine or isoflurane induction prior to isoflurane anesthesia in medetomidine-premedicated dogs. | Journal of the American Animal Hospital Association 20010101 |
| The effect of a combination of medetomidine-butorphanol and medetomidine, butorphanol, atropine on glomerular filtration rate in dogs. | Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association 20010101 |
| Anesthetic and cardiopulmonary effects of propofol in dogs premedicated with atropine, butorphanol, and medetomidine. | Veterinary therapeutics : research in applied veterinary medicine 20010101 |
| Dexmedetomidine as an anesthetic adjunct in coronary artery bypass grafting. | Anesthesiology 19970201 |
| Beneficial effects of dexmedetomidine on ischaemic myocardium of anaesthetized dogs. | British journal of anaesthesia 19960901 |
| Postoperative analgesic and cardiopulmonary effects in dogs of oxymorphone administered epidurally and intramuscularly, and medetomidine administered epidurally: a comparative clinical study. | Veterinary surgery : VS 19960101 |
| Further characterization of the receptor mechanism involved in the antidysrhythmic effect of dexmedetomidine on halothane/epinephrine dysrhythmias in dogs. | Anesthesiology 19951101 |
| Role of the vagus nerve in the antidysrhythmic effect of dexmedetomidine on halothane/epinephrine dysrhythmias in dogs. | Anesthesiology 19951101 |
| Comparison of intramuscular dexmedetomidine and midazolam premedication for elective abdominal hysterectomy. | Anesthesia and analgesia 19941001 |
| Comparison of neurologic responses to the use of medetomidine as a sole agent or preanesthetic in laboratory beagles. | Acta veterinaria Scandinavica 19920101 |
| Effects of anticholinergic treatment on the cardiac and respiratory systems in dogs sedated with medetomidine. | The Veterinary record 19911005 |
| Rapid reversal of alpha 2-adrenoceptor agonist effects by atipamezole in human volunteers. | British journal of clinical pharmacology 19910201 |
| Dexmedetomidine, a selective alpha 2-agonist, does not potentiate the cardiorespiratory depression of alfentanil in the rat. | Anesthesiology 19900501 |
| Dexmedetomidine, acting through central alpha-2 adrenoceptors, prevents opiate-induced muscle rigidity in the rat. | Anesthesiology 19890801 |
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