CAS 106516-24-9 | Sertindole | CAS Number 106516-24-9

Title	Journal
Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model.	Toxicological sciences : an official journal of the Society of Toxicology 20131201
The efficacy and safety of 12 weeks of treatment with sertindole or olanzapine in patients with chronic schizophrenia who did not respond successfully to their previous treatments: a randomized, double-blind, parallel-group, flexible-dose study.	International clinical psychopharmacology 20121101
Drug safety and efficacy evaluation of sertindole for schizophrenia.	Expert opinion on drug safety 20121101
Effects of sertindole on cognition in clozapine-treated schizophrenia patients.	Acta psychiatrica Scandinavica 20120701
Sertindole in the long-term treatment of schizophrenia.	International clinical psychopharmacology 20120701
Augmenting clozapine with sertindole: a double-blind, randomized, placebo-controlled study.	Journal of clinical psychopharmacology 20120401
Effects of quetiapine and sertindole on subchronic ketamine-induced deficits in attentional set-shifting in rats.	Psychopharmacology 20120301
Driving ability under sertindole.	Pharmacopsychiatry 20120301
Characterization of [³H]Lu AE60157 ([³H]8-(4-methylpiperazin-1-yl)-3-phenylsulfonylquinoline) binding to 5-hydroxytryptamine₆ (5-HT₆) receptors in vivo.	European journal of pharmacology 20120215
Second-generation antipsychotic drugs and extrapyramidal side effects: a systematic review and meta-analysis of head-to-head comparisons.	Schizophrenia bulletin 20120101
Recent advances in imaging of dopaminergic neurons for evaluation of neuropsychiatric disorders.	Journal of biomedicine & biotechnology 20120101
Critical appraisal of lurasidone in the management of schizophrenia.	Neuropsychiatric disease and treatment 20120101
Sudden death of cardiac origin and psychotropic drugs.	Frontiers in pharmacology 20120101
Role of aripiprazole in treatment-resistant schizophrenia.	Neuropsychiatric disease and treatment 20120101
Sertindole, a potent antagonist at dopamine D₂ receptors, induces autophagy by increasing reactive oxygen species in SH-SY5Y neuroblastoma cells.	Biological & pharmaceutical bulletin 20120101
Prediction of chemical-protein interactions network with weighted network-based inference method.	PloS one 20120101
A pharmacoeconomic analysis of sertindole in the treatment of schizophrenia in Sweden.	Nordic journal of psychiatry 20111201
The effects of sertindole on sensory gating, sensorimotor gating, and cognition in healthy volunteers.	Journal of psychopharmacology (Oxford, England) 20111201
Effects of olanzapine, sertindole and clozapine on MK-801 induced visual memory deficits in mice.	Pharmacology, biochemistry, and behavior 20111001
Antipsychotic drugs rapidly induce dopamine neuron depolarization block in a developmental rat model of schizophrenia.	The Journal of neuroscience : the official journal of the Society for Neuroscience 20110824
Serotonin control of sleep-wake behavior.	Sleep medicine reviews 20110801
Sertindole-associated deep venous thrombosis.	Journal of clinical psychopharmacology 20110801
Relationship between P-glycoprotein and second-generation antipsychotics.	Pharmacogenomics 20110801
Computer simulations of structure-activity relationships for HERG channel blockers.	Biochemistry 20110712
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.	Cardiovascular research 20110701
Metabolic parameters in the short- and long-term treatment of schizophrenia with sertindole or risperidone.	European archives of psychiatry and clinical neuroscience 20110601
Pain, affect and psychotic illness.	European archives of psychiatry and clinical neuroscience 20110601
Effects on prolongation of Bazett's corrected QT interval of seven second-generation antipsychotics in the treatment of schizophrenia: a meta-analysis.	Journal of psychopharmacology (Oxford, England) 20110501
Effects of olanzapine, sertindole and clozapine on learning and memory in the Morris water maze test in naive and MK-801-treated mice.	Pharmacology, biochemistry, and behavior 20110501
Simulation of the undiseased human cardiac ventricular action potential: model formulation and experimental validation.	PLoS computational biology 20110501
Sertindole restores attentional performance and suppresses glutamate release induced by the NMDA receptor antagonist CPP.	Psychopharmacology 20110401
The effects of NMDA receptor antagonists on attentional set-shifting task performance in mice.	Psychopharmacology 20110401
Androgen insensitivity and liability to drug-induced extrapyramidal symptoms.	Gender medicine 20110401
A novel approach for predicting P-glycoprotein (ABCB1) inhibition using molecular interaction fields.	Journal of medicinal chemistry 20110324
Analysis of Relationship between Levofloxacin and Corrected QT Prolongation Using a Clinical Data Warehouse.	Healthcare informatics research 20110301
Dose-response relationship of sertindole and haloperidol using the pharmacopsychometric triangle.	Acta psychiatrica Scandinavica 20110201
A double-blind, randomized study comparing the efficacy and safety of sertindole and risperidone in patients with treatment-resistant schizophrenia.	The Journal of clinical psychiatry 20110201
The use of PET imaging in studying cognition, genetics and pharmacotherapeutic interventions in schizophrenia.	Expert review of neurotherapeutics 20110101
Risperidone versus other atypical antipsychotics for schizophrenia.	The Cochrane database of systematic reviews 20110101
Identification and synthesis of impurities formed during sertindole preparation.	Beilstein journal of organic chemistry 20110101
Paliperidone extended-release: does it have a place in antipsychotic therapy?	Drug design, development and therapy 20110101
Pharmacotherapy for treatment-resistant schizophrenia.	Neuropsychiatric disease and treatment 20110101
AUTISM Spectrum Disorders and Suicidality.	Clinical practice and epidemiology in mental health : CP & EMH 20110101
hERGAPDbase: a database documenting hERG channel inhibitory potentials and APD-prolongation activities of chemical compounds.	Database : the journal of biological databases and curation 20110101
Role of sublingual asenapine in treatment of schizophrenia.	Neuropsychiatric disease and treatment 20110101
[The experience of using the atypical antipsychotic sertindole in psychiatric inpatient clinics in Russia].	Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101
Clinical potential of lurasidone in the management of schizophrenia.	Therapeutics and clinical risk management 20110101
A novel study design for antibiotic trials in acute exacerbations of COPD: MAESTRAL methodology.	International journal of chronic obstructive pulmonary disease 20110101
Drug-emergent metabolic syndrome in patients with schizophrenia receiving atypical (second-generation) antipsychotics.	Indian journal of psychiatry 20110101
Open-label study of the short-term effects of memantine on FDG-PET in frontotemporal dementia.	Neuropsychiatric disease and treatment 20110101
Long-acting injectable risperidone in partially adherent and nonadherent patients with schizophrenia.	Neuropsychiatric disease and treatment 20110101
Identification of novel functional inhibitors of acid sphingomyelinase.	PloS one 20110101
Assessment of effectiveness measures in patients with schizophrenia initiated on risperidone long-acting therapy: the SOURCE study results.	BMC psychiatry 20110101
[Pharmacoepidemiological and toxicological aspects of atypical neuroleptics usage].	Przeglad lekarski 20110101
Human engineered heart tissue as a versatile tool in basic research and preclinical toxicology.	PloS one 20110101
Comparative Molecular Field Analysis (CoMFA) and Comparative Molecular Similarity Indices Analysis (CoMSIA) studies on α(1A)-adrenergic receptor antagonists based on pharmacophore molecular alignment.	International journal of molecular sciences 20110101
Clinical utility of the risperidone formulations in the management of schizophrenia.	Neuropsychiatric disease and treatment 20110101
Pisa syndrome and laryngeal dystonia induced by novel antipsychotics.	The Israel journal of psychiatry and related sciences 20110101
Effect of neuroleptics on cytochrome P450 2C11 (CYP2C11) in rat liver.	Pharmacological reports : PR 20110101
An open, large, 6-month naturalistic study of outcome in schizophrenic outpatients, treated with olanzapine.	Human psychopharmacology 20110101
Suicide attempts in a prospective cohort of patients with schizophrenia treated with sertindole or risperidone.	European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20101201
Sertindole for the treatment of schizophrenia.	Expert opinion on pharmacotherapy 20101201
Identification of human Ether-à-go-go related gene modulators by three screening platforms in an academic drug-discovery setting.	Assay and drug development technologies 20101201
Gateways to clinical trials.	Methods and findings in experimental and clinical pharmacology 20101201
Combined treatment with quetiapine and sertindole in therapy refractory insomnia after clozapine discontinuation.	Journal of psychopharmacology (Oxford, England) 20101101
Safety of sertindole versus risperidone in schizophrenia: principal results of the sertindole cohort prospective study (SCoP).	Acta psychiatrica Scandinavica 20101101
Head-to-head comparisons of metabolic side effects of second generation antipsychotics in the treatment of schizophrenia: a systematic review and meta-analysis.	Schizophrenia research 20101101
A head-to-head comparison of sertindole and risperidone on metabolic parameters.	Schizophrenia research 20101101
Mortality in schizophrenia: a measurable clinical endpoint.	Journal of psychopharmacology (Oxford, England) 20101101
Antipsychotic-associated all-cause and cardiac mortality: what should we worry about and how should the risk be assessed?	Acta psychiatrica Scandinavica 20101101
Exploring the neuroleptic substituent in octoclothepin: potential ligands for positron emission tomography with subnanomolar affinity for α(1)-adrenoceptors.	Journal of medicinal chemistry 20101014
Divergent acute and chronic modulation of glutamatergic postsynaptic density genes expression by the antipsychotics haloperidol and sertindole.	Psychopharmacology 20101001
Validation and pharmacological characterisation of MK-801-induced locomotor hyperactivity in BALB/C mice as an assay for detection of novel antipsychotics.	Psychopharmacology 20101001
Treatment with antipsychotics and the risk of diabetes in clinical practice.	The British journal of psychiatry : the journal of mental science 20101001
Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands.	Bioorganic & medicinal chemistry letters 20100915
Pharmacologic treatment of schizophrenia.	Dialogues in clinical neuroscience 20100901
Antipsychotic drug-induced increases in ventral tegmental area dopamine neuron population activity via activation of the nucleus accumbens-ventral pallidum pathway.	The international journal of neuropsychopharmacology 20100801
Sertindole and fluoxetine overdose with benign outcome.	Nordic journal of psychiatry 20100801
Sertindole and impaired atrioventricular function, in the absence of Q-T prolongation: a case report.	Psychiatry and clinical neurosciences 20100801
The effect of sertindole on QTD and TPTE.	Acta psychiatrica Scandinavica 20100501
Oculogyric crisis with sertindole monotherapy.	Pharmacopsychiatry 20100501
The amiodarone derivative KB130015 activates hERG1 potassium channels via a novel mechanism.	European journal of pharmacology 20100425
Ejaculatory dysfunction in patient with schizophrenia on sertindole.	Psychiatria Danubina 20100301
The European post-marketing observational sertindole study: an investigation of the safety of antipsychotic drug treatment.	European archives of psychiatry and clinical neuroscience 20100201
Zotepine versus other atypical antipsychotics for schizophrenia.	The Cochrane database of systematic reviews 20100120
Mazindol attenuates ketamine-induced cognitive deficit in the attentional set shifting task in rats.	European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20100101
Sertindole improves sub-chronic PCP-induced reversal learning and episodic memory deficits in rodents: involvement of 5-HT(6) and 5-HT (2A) receptor mechanisms.	Psychopharmacology 20100101
Amisulpride versus other atypical antipsychotics for schizophrenia.	The Cochrane database of systematic reviews 20100101
Quetiapine versus other atypical antipsychotics for schizophrenia.	The Cochrane database of systematic reviews 20100101
First-generation vs second-generation antipsychotic drugs: The ongoing saga.	Indian journal of psychiatry 20100101
QT alterations in psychopharmacology: proven candidates and suspects.	Current drug safety 20100101
Olanzapine versus other atypical antipsychotics for schizophrenia.	The Cochrane database of systematic reviews 20100101
Behavioral and neurobiological changes in C57BL/6 mouse exposed to cuprizone: effects of antipsychotics.	Frontiers in behavioral neuroscience 20100101
New atypical antipsychotics for schizophrenia: iloperidone.	Drug design, development and therapy 20100101
Two four-marker haplotypes on 7q36.1 region indicate that the potassium channel gene HERG1 (KCNH2, Kv11.1) is related to schizophrenia: a case control study.	Behavioral and brain functions : BBF 20100101
Emerging role of sertindole in the management of schizophrenia.	Neuropsychiatric disease and treatment 20100101
Emerging treatments in the management of schizophrenia - focus on sertindole.	Drug design, development and therapy 20100101
Profile of olanzapine long-acting injection for the maintenance treatment of adult patients with schizophrenia.	Neuropsychiatric disease and treatment 20100101
Not all partial dopamine D(2) receptor agonists are the same in treating schizophrenia. Exploring the effects of bifeprunox and aripiprazole using a computer model of a primate striatal dopaminergic synapse.	Neuropsychiatric disease and treatment 20100101
Predictably irrational: assaying cognitive inflexibility in mouse models of schizophrenia.	Frontiers in neuroscience 20100101
Zotepine versus other atypical antipsychotics for schizophrenia.	The Cochrane database of systematic reviews 20100101
Clozapine versus other atypical antipsychotics for schizophrenia.	The Cochrane database of systematic reviews 20100101
Development, clinical utility, and place in therapy of posaconazole for prevention and treatment of invasive fungal infections.	Drug design, development and therapy 20100101
[Cardiovascular risk of haloperidol vs. atypical anti-psychotic drugs in schizophrenia treatment].	Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20100101
Metabolic risk in selected second-generation antipsychotics.	Bratislavske lekarske listy 20100101
Translational Aspects of the Novel Object Recognition Task in Rats Abstinent Following Sub-Chronic Treatment with Phencyclidine (PCP): Effects of Modafinil and Relevance to Cognitive Deficits in Schizophrenia.	Frontiers in psychiatry 20100101
Safety and tolerability of antipsychotics: focus on amisulpride.	Drug, healthcare and patient safety 20100101
Stereoselective Inhibition of the hERG1 Potassium Channel.	Frontiers in pharmacology 20100101
Therapeutic drug monitoring of seven psychotropic drugs and four metabolites in human plasma by HPLC-MS.	Journal of pharmaceutical and biomedical analysis 20091205
Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors.	Bioorganic & medicinal chemistry letters 20091201
The comorbidity of diabetes mellitus and psychiatric disorders.	Psychiatria Danubina 20091201
Comparative Analysis of Cognitive Function in Schizophrenia with and without Obsessive Compulsive Disorder.	Psychiatry investigation 20091201
The pNNx Heart Rate Variability Statistics: An Application to Neuroautonomic Dysfunction of Clozapine-Treated Subjects.	Psychiatry investigation 20091201
Mechanisms of action of antipsychotic drugs of different classes, refractoriness to therapeutic effects of classical neuroleptics, and individual variation in sensitivity to their actions: Part I.	Current neuropharmacology 20091201
Mechanisms of action of antipsychotic drugs of different classes, refractoriness to therapeutic effects of classical neuroleptics, and individual variation in sensitivity to their actions: Part II.	Current neuropharmacology 20091201
Reversal of cognitive deficits by an ampakine (CX516) and sertindole in two animal models of schizophrenia--sub-chronic and early postnatal PCP treatment in attentional set-shifting.	Psychopharmacology 20091101
Asenapine effects in animal models of psychosis and cognitive function.	Psychopharmacology 20091101
Sertindole causes distinct electrocardiographic T-wave morphology changes.	European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20091001
FDG-PET and MRI imaging of the effects of sertindole and haloperidol in the prefrontal lobe in schizophrenia.	Schizophrenia research 20091001
Effect of sertindole on extracellular dopamine, acetylcholine, and glutamate in the medial prefrontal cortex of conscious rats: a comparison with risperidone and exploration of mechanisms involved.	Psychopharmacology 20090901
Iatrogenic QT Abnormalities and Fatal Arrhythmias: Mechanisms and Clinical Significance.	Current cardiology reviews 20090801
Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers.	Journal of medicinal chemistry 20090723
Are weight gain and metabolic side effects of atypical antipsychotics dose dependent? A literature review.	The Journal of clinical psychiatry 20090701
Pharmacokinetics of sertindole and its metabolite dehydrosertindole in rats and characterization of their comparative pharmacodynamics based on in vivo D2 receptor occupancy and behavioural conditioned avoidance response.	Biopharmaceutics & drug disposition 20090501
Further characterization of the discriminative stimulus properties of the atypical antipsychotic drug clozapine in C57BL/6 mice: role of 5-HT(2A) serotonergic and alpha (1) adrenergic antagonism.	Psychopharmacology 20090401
Review of the efficacy of placebo in comparative clinical trials between typical and atypical antipsychotics.	Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) 20090301
Stability of medication in early psychosis: a comparison between second-generation and low-dose first-generation antipsychotics.	Early intervention in psychiatry 20090201
Comparison of haloperidol, risperidone, sertindole, and modafinil to reverse an attentional set-shifting impairment following subchronic PCP administration in the rat--a back translational study.	Psychopharmacology 20090101
Effects of Subchronic Phencyclidine (PCP) Treatment on Social Behaviors, and Operant Discrimination and Reversal Learning in C57BL/6J Mice.	Frontiers in behavioral neuroscience 20090101
Sertindole versus other atypical antipsychotics for schizophrenia.	The Cochrane database of systematic reviews 20090101
Treatment of schizophrenia with antipsychotics in Norwegian emergency wards, a cross-sectional national study.	BMC psychiatry 20090101
Combination therapy or monotherapy for the depressed type of schizoaffective disorder.	Neuropsychiatric disease and treatment 20090101
Maintenance electroconvulsive therapy for comorbid pharmacotherapy-refractory obsessive-compulsive and schizoaffective disorder.	European journal of medical research 20090101
rTMS of the left dorsolateral prefrontal cortex modulates dopamine release in the ipsilateral anterior cingulate cortex and orbitofrontal cortex.	PloS one 20090101
Aripiprazole versus other atypical antipsychotics for schizophrenia.	The Cochrane database of systematic reviews 20090101
Asenapine monotherapy in the acute treatment of both schizophrenia and bipolar I disorder.	Neuropsychiatric disease and treatment 20090101
Measurement of treatment adherence with antipsychotic agents in patients with schizophrenia.	Neuropsychiatric disease and treatment 20090101
Antipsychotics and risk of venous thromboembolism: A population-based case-control study.	Clinical epidemiology 20090101
The antagonistic effect of antipsychotic drugs on a HEK293 cell line stably expressing human alpha1A1-adrenoceptors.	European journal of pharmacology 20081031
Reversal of subchronic PCP-induced deficits in attentional set shifting in rats by sertindole and a 5-HT6 receptor antagonist: comparison among antipsychotics.	Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20081001
Direct and indirect effects of paliperidone extended-release tablets on negative symptoms of schizophrenia.	Neuropsychiatric disease and treatment 20081001
Effect of sertindole on QTc interval in patients with schizophrenia.	Neuroscience letters 20080905
Do we need another atypical antipsychotic?	European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20080801
Orthostatic hypotensive effect of antipsychotic drugs in Wistar rats by in vivo and in vitro studies of alpha1-adrenoceptor function.	Psychopharmacology 20080701
Recruitment of beta-arrestin2 to the dopamine D2 receptor: insights into anti-psychotic and anti-parkinsonian drug receptor signaling.	Neuropharmacology 20080601
Antipsychotics for the treatment of behavioral and psychological symptoms of dementia (BPSD).	Current neuropharmacology 20080601
Dopamine D2(High) receptors moderately elevated by sertindole.	Synapse (New York, N.Y.) 20080501
The Sertindole Cohort Prospective (SCoP) study: rationale, design and methodology.	Pharmacoepidemiology and drug safety 20080501
Sertindole: pharmacological and clinical profile and role in the treatment of schizophrenia.	Expert opinion on drug metabolism & toxicology 20080501
Using pharmacokinetic-pharmacodynamic modelling as a tool for prediction of therapeutic effective plasma levels of antipsychotics.	European journal of pharmacology 20080428
[Trends in psychiatry].	Revue medicale suisse 20080116
Cardiac side effects of psychiatric drugs.	Human psychopharmacology 20080101
Incorporating clinical guidelines through clinician decision-making.	Implementation science : IS 20080101
Evaluation of patients on sertindole treatment after failure of other antipsychotics: a retrospective analysis.	BMC psychiatry 20080101
Associations between venous thromboembolism and antipsychotics. A study of the WHO database of adverse drug reactions.	Drug safety 20080101
The Sertindole Safety Survey: a retrospective analysis under a named patient use programme in Europe.	BMC psychiatry 20080101
The effect of antipsychotic medication on sexual function and serum prolactin levels in community-treated schizophrenic patients: results from the Schizophrenia Trial of Aripiprazole (STAR) study (NCT00237913).	BMC psychiatry 20080101
[Potentially lethal cardiac side effects caused by psychiatric drugs].	Vertex (Buenos Aires, Argentina) 20080101
Current therapeutic options for Alzheimer's disease.	Current genomics 20071201
Course of recovery of cognitive impairment in patients with schizophrenia: a randomised double-blind study comparing sertindole and haloperidol.	Pharmacopsychiatry 20071101
Marked elevation of creatine kinase with sertindole: a case report.	Pharmacopsychiatry 20071101
Pharmacological causes of hyperprolactinemia.	Therapeutics and clinical risk management 20071001
Reversal of PCP-induced learning and memory deficits in the Morris' water maze by sertindole and other antipsychotics.	Psychopharmacology 20070801
Status epilepticus associated with sertindole.	European journal of neurology 20070801
The European sertindole safety and exposure survey: a follow-up study of 8600 patients.	Pharmacoepidemiology and drug safety 20070701
Atypical antipsychotic drugs: current issues of safety and efficacy in the management of schizophrenia.	Current opinion in investigational drugs (London, England : 2000) 20070701
Simultaneous prescribing of atypical antipsychotics, conventional antipsychotics and anticholinergics-a European study.	Pharmacy world & science : PWS 20070601
Antipsychotics for delirium.	The Cochrane database of systematic reviews 20070418
Sertindole: new drug. Another 'atypical' neuroleptic; QT prolongation.	Prescrire international 20070401
Quetiapine in the treatment of schizophrenia and related disorders.	Neuropsychiatric disease and treatment 20070401
An alternative approach to measuring treatment persistence with antipsychotic agents among patients with schizophrenia in the Veterans Health Administration.	Neuropsychiatric disease and treatment 20070401
The use of amisulpride in the treatment of acute psychosis.	Therapeutics and clinical risk management 20070301
Long-acting risperidone injection: efficacy, safety, and cost-effectiveness of the first long-acting atypical antipsychotic.	Neuropsychiatric disease and treatment 20070201
Metabolic drug interactions with newer antipsychotics: a comparative review.	Basic & clinical pharmacology & toxicology 20070101
Metabolic syndrome in Thai schizophrenic patients: a naturalistic one-year follow-up study.	BMC psychiatry 20070101
Clinical pharmacokinetics of atypical antipsychotics: a critical review of the relationship between plasma concentrations and clinical response.	Clinical pharmacokinetics 20070101
Adverse effects of atypical antipsychotics : differential risk and clinical implications.	CNS drugs 20070101
The activity of cytochrome P450 CYP2B in rat liver during neuroleptic treatment.	Pharmacological reports : PR 20070101
Pharmacological treatment of primary negative symptoms in schizophrenia: a systematic review.	Schizophrenia research 20061201
Comparing sertindole to other new generation antipsychotics on preferential dopamine output in limbic versus striatal projection regions: mechanism of action.	Synapse (New York, N.Y.) 20061201
Atypical antipsychotics to treat the neuropsychiatric symptoms of dementia.	Neuropsychiatric disease and treatment 20061201
Beat-to-Beat variability of repolarization determines proarrhythmic outcome in dogs susceptible to drug-induced torsades de pointes.	Journal of the American College of Cardiology 20060919
Chlorpromazine, clozapine and olanzapine inhibit anionic amino acid transport in cultured human fibroblasts.	Amino acids 20060901
Sertindole: efficacy and safety in schizophrenia.	Expert opinion on pharmacotherapy 20060901
Classical as well as novel antipsychotic drugs increase self-stimulation threshold in the rat--similar mechanism of action?	European journal of pharmacology 20060821
Sertindole, in contrast to clozapine and olanzapine, does not disrupt water maze performance after acute or chronic treatment.	European journal of pharmacology 20060807
Effects of antipsychotic drugs on I(to), I (Na), I (sus), I (K1), and hERG: QT prolongation, structure activity relationship, and network analysis.	Pharmaceutical research 20060601
Haloperidol dose when used as active comparator in randomized controlled trials with atypical antipsychotics in schizophrenia: comparison with officially recommended doses.	The Journal of clinical psychiatry 20060601
The use of atypical antipsychotics beyond psychoses: efficacy of quetiapine in bipolar disorder.	Neuropsychiatric disease and treatment 20060601
New insights about HERG blockade obtained from protein modeling, potential energy mapping, and docking studies.	Bioorganic & medicinal chemistry 20060501
Myocardium distribution of sertindole and its metabolite dehydrosertindole in guinea-pigs.	Biopharmaceutics & drug disposition 20060501
Comparative evaluation of HERG currents and QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs.	The Journal of pharmacology and experimental therapeutics 20060301
The German Research Network on Schizophrenia--impact on the management of schizophrenia.	Dialogues in clinical neuroscience 20060301
A dopaminergic deficit hypothesis of schizophrenia: the path to discovery.	Dialogues in clinical neuroscience 20060301
The effectiveness of atypical antipsychotics for the treatment of aggression and psychosis in Alzheimer's disease.	The Cochrane database of systematic reviews 20060125
A double-blind, controlled study of sertindole versus risperidone in the treatment of moderate-to-severe schizophrenia.	International clinical psychopharmacology 20060101
Sertindole : a review of its use in schizophrenia.	CNS drugs 20060101
Pharmacological treatment of ambulatory schizophrenic patients in Belgium.	Clinical practice and epidemiology in mental health : CP & EMH 20060101
QTc interval prolongation and antipsychotic drug treatments: focus on sertindole.	The international journal of neuropsychopharmacology 20051201
Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist.	The Journal of pharmacology and experimental therapeutics 20051201
Adjunctive treatment with mianserin enhances effects of raclopride on cortical dopamine output and, in parallel, its antipsychotic-like effect.	Neuropsychiatric disease and treatment 20051201
Generalization to atypical antipsychotic drugs depends on training dose in rats trained to discriminate 1.25 mg/kg clozapine versus 5.0 mg/kg clozapine versus vehicle in a three-choice drug discrimination task.	Behavioural pharmacology 20051101
Treatment with the new antipsychotic sertindole for late-occurring undesirable movement effects.	International clinical psychopharmacology 20051101
Atypical antipsychotics produce within-session decrements on self-stimulation of the rat medial prefrontal cortex.	Frontiers in bioscience : a journal and virtual library 20050901
Comparison of methanol and acetonitrile as solvents for the separation of sertindole and its major metabolites by capillary zone electrophoresis.	Electrophoresis 20050901
Adjunctive treatment with mianserin enhances effects of raclopride on cortical dopamine output and, in parallel, its antipsychotic-like effect.	Neuropsychiatric disease and treatment 20050901
Sertindole for schizophrenia.	The Cochrane database of systematic reviews 20050720
Current therapy issues and unmet clinical needs in the treatment of schizophrenia: a review of the new generation antipsychotics.	International clinical psychopharmacology 20050701
Exploring blocker binding to a homology model of the open hERG K+ channel using docking and molecular dynamics methods.	FEBS letters 20050523
Antipsychotics lack alpha 1A/B adrenoceptor subtype selectivity in the rat.	European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20050301
Simplified ultraviolet liquid chromatographic method for determination of sertindole, dehydrosertindole and norsertindole, in human plasma.	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050105
Inhibition of rat liver CYP2D in vitro and after 1-day and long-term exposure to neuroleptics in vivo-possible involvement of different mechanisms.	European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20050101
Atypical antipsychotics: from potassium channels to torsade de pointes and sudden death.	Drug safety 20050101
Unbiased descriptor and parameter selection confirms the potential of proteochemometric modelling.	BMC bioinformatics 20050101
Choice of cardiac tissue plays an important role in the evaluation of drug-induced prolongation of the QT interval in vitro in rabbit.	Journal of pharmacological and toxicological methods 20050101
Hostility and violence of acute psychiatric inpatients.	Clinical practice and epidemiology in mental health : CP & EMH 20050101
Neuropsychological measures of attention and memory function in schizophrenia: relationships with symptom dimensions and serum monoamine activity.	Behavioral and brain functions : BBF 20050101
Direct effects of neuroleptics on the activity of CYP2A in the liver of rats.	Pharmacological reports : PR 20050101
Interactions between neuroleptics and CYP2C6 in rat liver--in vitro and ex vivo study.	Pharmacological reports : PR 20050101
Clinical observations of sertindole in 53 hospitalised patients with psychotic disorders.	Clinical drug investigation 20050101
Possible induction of mania or hypomania by atypical antipsychotics: an updated review of reported cases.	The Journal of clinical psychiatry 20041101
[Psychotropics and weight gain].	Praxis 20040825
Determination of myocardium to plasma concentration ratios of five antipsychotic drugs: comparison with their ability to induce arrhythmia and sudden death in clinical practice.	Toxicology and applied pharmacology 20040815
Evidence-based pharmacotherapy of schizophrenia.	The international journal of neuropsychopharmacology 20040601
New alpha(1)-adrenoceptor antagonists derived from the antipsychotic sertindole - carbon-11 labelling and pet examination of brain uptake in the cynomolgus monkey.	Nuclear medicine and biology 20040401
Selective optimization of side activities: another way for drug discovery.	Journal of medicinal chemistry 20040311
Treatment-refractory schizophrenia.	Dialogues in clinical neuroscience 20040301
Differing response to antipsychotic therapy in schizophrenia: pharmacogenomic aspects.	Dialogues in clinical neuroscience 20040301
Sex-dependent modulation of treatment response.	Dialogues in clinical neuroscience 20040301
Atypical antipsychotics: pharmacokinetics, therapeutic drug monitoring and pharmacological interactions.	Current medicinal chemistry 20040201
[Current pharmacotherapy of schizophrenia].	Orvosi hetilap 20040118
Cardiovascular side effects of new antidepressants and antipsychotics: new drugs, old concerns?	Current pharmaceutical design 20040101
Introduction to sertindole in clinical practice.	CNS drugs 20040101
A review of the efficacy, tolerability and safety of sertindole in clinical trials.	CNS drugs 20040101
Case histories illustrating the utility of sertindole in clinical practice.	CNS drugs 20040101
Impact of atypical antipsychotics on quality of life in patients with schizophrenia.	CNS drugs 20040101
Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia.	British journal of cancer 20031117
Electrophysiological safety of sertindole in dogs with normal and remodeled hearts.	The Journal of pharmacology and experimental therapeutics 20031101
Enhancement of latent inhibition by two 5-HT2A receptor antagonists only when given at both pre-exposure and conditioning.	Psychopharmacology 20030901
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.	Bioorganic & medicinal chemistry letters 20030818
Antipsychotic medication and seizures: a review.	Drugs of today (Barcelona, Spain : 1998) 20030701
Alpha(1) adrenoceptor subtype selectivity. 3D-QSAR models for a new class of alpha(1) adrenoceptor antagonists derived from the novel antipsychotic sertindole.	Journal of molecular graphics & modelling 20030601
Biases affecting the proportional reporting ratio (PPR) in spontaneous reports pharmacovigilance databases: the example of sertindole.	Pharmacoepidemiology and drug safety 20030601
Dealing with uncertainty in drug safety: lessons for the future from sertindole.	Pharmacoepidemiology and drug safety 20030601
The relevance of prolonged QTc measurement to pediatric psychopharmacology.	Journal of the American Academy of Child and Adolescent Psychiatry 20030601
Understanding the structure-activity relationship of the human ether-a-go-go-related gene cardiac K+ channel. A model for bad behavior.	Journal of medicinal chemistry 20030522
Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches.	Bioorganic & medicinal chemistry letters 20030519
New generation antipsychotics versus low-potency conventional antipsychotics: a systematic review and meta-analysis.	Lancet (London, England) 20030510
Synthesis and structure-affinity relationship investigations of 5-aminomethyl and 5-carbamoyl analogues of the antipsychotic sertindole. A new class of selective alpha1 adrenoceptor antagonists.	Bioorganic & medicinal chemistry 20030320
H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs.	Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030301
Detection of proarrhythmia in the female rabbit heart: blinded validation.	Journal of cardiovascular electrophysiology 20030301
Synthesis and structure-affinity relationship investigations of 5-heteroaryl-substituted analogues of the antipsychotic sertindole. A new class of highly selective alpha(1) adrenoceptor antagonists.	Journal of medicinal chemistry 20030116
Gateways to clinical trials.	Methods and findings in experimental and clinical pharmacology 20030101
QTc prolongation due to propranolol overdose.	International journal of psychiatry in medicine 20030101
Influence of classic and atypical neuroleptics on caffeine oxidation in rat liver microsomes.	Polish journal of pharmacology 20030101
The potential cardiotoxicity of antipsychotic drugs as assessed by heart rate variability.	Journal of psychopharmacology (Oxford, England) 20021201
Development of neuroleptic agents: pharmacogenetics and current safety issues of regulatory concern.	Dialogues in clinical neuroscience 20021201
Optimizing dosing in atypical neuroleptic monotherapy.	Dialogues in clinical neuroscience 20021201
Obesity and related metabolic abnormalities during antipsychotic drug administration: mechanisms, management and research perspectives.	Pharmacopsychiatry 20021101
A comparison of the receptor binding and HERG channel affinities for a series of antipsychotic drugs.	European journal of pharmacology 20020816
Stimulation by antipsychotic agents of mitogen-activated protein kinase (MAPK) coupled to cloned, human (h)serotonin (5-HT)(1A) receptors.	Psychopharmacology 20020701
Low striatal and extra-striatal D2 receptor occupancy during treatment with the atypical antipsychotic sertindole.	Psychopharmacology 20020601
Striatal dopamine-2 receptor occupancy as measured with [123I]iodobenzamide and SPECT predicted the occurrence of EPS in patients treated with atypical antipsychotics and haloperidol.	Psychopharmacology 20020601
Variations in prescribing atypical antipsychotic drugs in primary care: cross-sectional study.	Pharmacoepidemiology and drug safety 20020601
Psychotropic drugs and the ECG: focus on the QTc interval.	Expert opinion on pharmacotherapy 20020501
Effects of the 5-HT(6) receptor antagonist, SB-271046, in animal models for schizophrenia.	Pharmacology, biochemistry, and behavior 20020401
Effects of antipsychotic drugs on operant responding after acute and repeated administration.	Psychopharmacology 20020301
Schizophrenia: genesis, receptorology and current therapeutics.	Current medicinal chemistry 20020301
Atypical antipsychotics: mechanism of action.	Canadian journal of psychiatry. Revue canadienne de psychiatrie 20020201
Electrophysiologic characterization of the antipsychotic drug sertindole in a rabbit heart model of torsade de pointes: low torsadogenic potential despite QT prolongation.	The Journal of pharmacology and experimental therapeutics 20020101
Antipsychotic-related QTc prolongation, torsade de pointes and sudden death.	Drugs 20020101
[Relationship between clozapine plasma levels and withdrawal symptoms].	Actas espanolas de psiquiatria 20020101
Investigation of the potential of clozapine to cause torsade de pointes.	Adverse drug reactions and toxicological reviews 20020101
[Schizoaffective disorder: clinical symptoms and present-day approach to treatment].	Medicina (Kaunas, Lithuania) 20020101
Agonist, antagonist, and inverse agonist properties of antipsychotics at human recombinant 5-HT(1A) receptors expressed in HeLa cells.	European journal of pharmacology 20011214
Novel antipsychotics and acute dystonic reactions.	The international journal of neuropsychopharmacology 20011201
Treatments for chronic psychosis.	Dialogues in clinical neuroscience 20011201
Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death.	The American journal of psychiatry 20011101
Development and evaluation of high throughput functional assay methods for HERG potassium channel.	Journal of biomolecular screening 20011001
Sertindole is a serotonin 5-HT2c inverse agonist and decreases agonist but not antagonist binding to 5-HT2c receptors after chronic treatment.	Psychopharmacology 20010901
The antipsychotic drugs sertindole and pimozide block erg3, a human brain K(+) channel.	Biochemical and biophysical research communications 20010824
Effects of acute versus chronic treatment with typical or atypical antipsychotics on d-amphetamine-induced sensorimotor gating deficits in rats.	Psychopharmacology 20010701
Comparative study of mortality rates and cardiac dysrhythmias in post-marketing surveillance studies of sertindole and two other atypical antipsychotic drugs, risperidone and olanzapine.	Journal of psychopharmacology (Oxford, England) 20010601
Recent developments in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress.	Journal of medicinal chemistry 20010524
The canine Purkinje fiber: an in vitro model system for acquired long QT syndrome and drug-induced arrhythmogenesis.	Journal of cardiovascular pharmacology 20010501
The muscarinic receptor agonist BuTAC, a novel potential antipsychotic, does not impair learning and memory in mouse passive avoidance.	Schizophrenia research 20010415
Traditional and new antipsychotic drugs differentially alter neurotransmission markers in basal ganglia-thalamocortical neural pathways.	Synapse (New York, N.Y.) 20010201
Effects of newer atypical antipsychotics on autonomic neurocardiac function: a comparison between amisulpride, olanzapine, sertindole, and clozapine.	Journal of clinical psychopharmacology 20010201
Atypical antipsychotics: new directions and new challenges in the treatment of schizophrenia.	Annual review of medicine 20010101
Cost effectiveness of the newer atypical antipsychotics: a review of the pharmacoeconomic research evidence.	Current opinion in investigational drugs (London, England : 2000) 20010101
Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxytryptamine2C receptors.	The Journal of pharmacology and experimental therapeutics 20001001
Quinpirole, 8-OH-DPAT and ketanserin modulate catalepsy induced by high doses of atypical antipsychotics.	Methods and findings in experimental and clinical pharmacology 19991101
Efficacy and extrapyramidal side-effects of the new antipsychotics olanzapine, quetiapine, risperidone, and sertindole compared to conventional antipsychotics and placebo. A meta-analysis of randomized controlled trials.	Schizophrenia research 19990104
Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study.	European journal of pharmacology 19980821
Antipsychotic drugs which elicit little or no parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors.	Molecular psychiatry 19980301
Do novel antipsychotics have similar pharmacological characteristics? A review of the evidence.	Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 19980201
Sertindole (Serdolect): preclinical and clinical findings of a new atypical antipsychotic.	Expert opinion on investigational drugs 19971101
[Sertindole, a novel alpha 1A-adrenoceptor selective antagonist].	Yao xue xue bao = Acta pharmaceutica Sinica 19970701
Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptors.	Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 19970201
Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding.	Psychopharmacology 19960301
Differential effects of classical and newer antipsychotics on the hypermotility induced by two dose levels of D-amphetamine.	European journal of pharmacology 19950905

Augmenting clozapine with sertindole: a double-blind, randomized, placebo-controlled study.

Journal of clinical psychopharmacology 20120401

Effects of quetiapine and sertindole on subchronic ketamine-induced deficits in attentional set-shifting in rats.

Psychopharmacology 20120301

Driving ability under sertindole.

Pharmacopsychiatry 20120301

Characterization of [³H]Lu AE60157 ([³H]8-(4-methylpiperazin-1-yl)-3-phenylsulfonylquinoline) binding to 5-hydroxytryptamine₆ (5-HT₆) receptors in vivo.

European journal of pharmacology 20120215

Second-generation antipsychotic drugs and extrapyramidal side effects: a systematic review and meta-analysis of head-to-head comparisons.

Schizophrenia bulletin 20120101

Recent advances in imaging of dopaminergic neurons for evaluation of neuropsychiatric disorders.

Journal of biomedicine & biotechnology 20120101

Critical appraisal of lurasidone in the management of schizophrenia.

Neuropsychiatric disease and treatment 20120101

Sudden death of cardiac origin and psychotropic drugs.

Frontiers in pharmacology 20120101

Role of aripiprazole in treatment-resistant schizophrenia.

Neuropsychiatric disease and treatment 20120101

Sertindole, a potent antagonist at dopamine D₂ receptors, induces autophagy by increasing reactive oxygen species in SH-SY5Y neuroblastoma cells.

Biological & pharmaceutical bulletin 20120101

Prediction of chemical-protein interactions network with weighted network-based inference method.

PloS one 20120101

A pharmacoeconomic analysis of sertindole in the treatment of schizophrenia in Sweden.

Nordic journal of psychiatry 20111201

The effects of sertindole on sensory gating, sensorimotor gating, and cognition in healthy volunteers.

Journal of psychopharmacology (Oxford, England) 20111201

Effects of olanzapine, sertindole and clozapine on MK-801 induced visual memory deficits in mice.

Pharmacology, biochemistry, and behavior 20111001

Antipsychotic drugs rapidly induce dopamine neuron depolarization block in a developmental rat model of schizophrenia.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20110824

Serotonin control of sleep-wake behavior.

Sleep medicine reviews 20110801

Sertindole-associated deep venous thrombosis.

Journal of clinical psychopharmacology 20110801

Relationship between P-glycoprotein and second-generation antipsychotics.

Pharmacogenomics 20110801

Computer simulations of structure-activity relationships for HERG channel blockers.

Biochemistry 20110712

Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.

Cardiovascular research 20110701

Metabolic parameters in the short- and long-term treatment of schizophrenia with sertindole or risperidone.

European archives of psychiatry and clinical neuroscience 20110601

Pain, affect and psychotic illness.

European archives of psychiatry and clinical neuroscience 20110601

Effects on prolongation of Bazett's corrected QT interval of seven second-generation antipsychotics in the treatment of schizophrenia: a meta-analysis.

Journal of psychopharmacology (Oxford, England) 20110501

Effects of olanzapine, sertindole and clozapine on learning and memory in the Morris water maze test in naive and MK-801-treated mice.

Pharmacology, biochemistry, and behavior 20110501

Simulation of the undiseased human cardiac ventricular action potential: model formulation and experimental validation.

PLoS computational biology 20110501

Sertindole restores attentional performance and suppresses glutamate release induced by the NMDA receptor antagonist CPP.

Psychopharmacology 20110401

The effects of NMDA receptor antagonists on attentional set-shifting task performance in mice.

Psychopharmacology 20110401

Androgen insensitivity and liability to drug-induced extrapyramidal symptoms.

Gender medicine 20110401

A novel approach for predicting P-glycoprotein (ABCB1) inhibition using molecular interaction fields.

Journal of medicinal chemistry 20110324

Analysis of Relationship between Levofloxacin and Corrected QT Prolongation Using a Clinical Data Warehouse.

Healthcare informatics research 20110301

Dose-response relationship of sertindole and haloperidol using the pharmacopsychometric triangle.

Acta psychiatrica Scandinavica 20110201

A double-blind, randomized study comparing the efficacy and safety of sertindole and risperidone in patients with treatment-resistant schizophrenia.

The Journal of clinical psychiatry 20110201

The use of PET imaging in studying cognition, genetics and pharmacotherapeutic interventions in schizophrenia.

Expert review of neurotherapeutics 20110101

Risperidone versus other atypical antipsychotics for schizophrenia.

The Cochrane database of systematic reviews 20110101

Identification and synthesis of impurities formed during sertindole preparation.

Beilstein journal of organic chemistry 20110101

Paliperidone extended-release: does it have a place in antipsychotic therapy?

Drug design, development and therapy 20110101

Pharmacotherapy for treatment-resistant schizophrenia.

Neuropsychiatric disease and treatment 20110101

AUTISM Spectrum Disorders and Suicidality.

Clinical practice and epidemiology in mental health : CP & EMH 20110101

hERGAPDbase: a database documenting hERG channel inhibitory potentials and APD-prolongation activities of chemical compounds.

Database : the journal of biological databases and curation 20110101

Role of sublingual asenapine in treatment of schizophrenia.

Neuropsychiatric disease and treatment 20110101

[The experience of using the atypical antipsychotic sertindole in psychiatric inpatient clinics in Russia].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101

Clinical potential of lurasidone in the management of schizophrenia.

Therapeutics and clinical risk management 20110101

A novel study design for antibiotic trials in acute exacerbations of COPD: MAESTRAL methodology.

International journal of chronic obstructive pulmonary disease 20110101

Drug-emergent metabolic syndrome in patients with schizophrenia receiving atypical (second-generation) antipsychotics.

Indian journal of psychiatry 20110101

Open-label study of the short-term effects of memantine on FDG-PET in frontotemporal dementia.

Neuropsychiatric disease and treatment 20110101

Long-acting injectable risperidone in partially adherent and nonadherent patients with schizophrenia.

Neuropsychiatric disease and treatment 20110101

Identification of novel functional inhibitors of acid sphingomyelinase.

PloS one 20110101

Assessment of effectiveness measures in patients with schizophrenia initiated on risperidone long-acting therapy: the SOURCE study results.

BMC psychiatry 20110101

[Pharmacoepidemiological and toxicological aspects of atypical neuroleptics usage].

Przeglad lekarski 20110101

Human engineered heart tissue as a versatile tool in basic research and preclinical toxicology.

PloS one 20110101

Comparative Molecular Field Analysis (CoMFA) and Comparative Molecular Similarity Indices Analysis (CoMSIA) studies on α(1A)-adrenergic receptor antagonists based on pharmacophore molecular alignment.

International journal of molecular sciences 20110101

Clinical utility of the risperidone formulations in the management of schizophrenia.

Neuropsychiatric disease and treatment 20110101

Pisa syndrome and laryngeal dystonia induced by novel antipsychotics.

The Israel journal of psychiatry and related sciences 20110101

Effect of neuroleptics on cytochrome P450 2C11 (CYP2C11) in rat liver.

Pharmacological reports : PR 20110101

An open, large, 6-month naturalistic study of outcome in schizophrenic outpatients, treated with olanzapine.

Human psychopharmacology 20110101

Suicide attempts in a prospective cohort of patients with schizophrenia treated with sertindole or risperidone.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20101201

Sertindole for the treatment of schizophrenia.

Expert opinion on pharmacotherapy 20101201

Identification of human Ether-à-go-go related gene modulators by three screening platforms in an academic drug-discovery setting.

Assay and drug development technologies 20101201

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology 20101201

Combined treatment with quetiapine and sertindole in therapy refractory insomnia after clozapine discontinuation.

Journal of psychopharmacology (Oxford, England) 20101101

Safety of sertindole versus risperidone in schizophrenia: principal results of the sertindole cohort prospective study (SCoP).

Acta psychiatrica Scandinavica 20101101

Head-to-head comparisons of metabolic side effects of second generation antipsychotics in the treatment of schizophrenia: a systematic review and meta-analysis.

Schizophrenia research 20101101

A head-to-head comparison of sertindole and risperidone on metabolic parameters.

Schizophrenia research 20101101

Mortality in schizophrenia: a measurable clinical endpoint.

Journal of psychopharmacology (Oxford, England) 20101101

Antipsychotic-associated all-cause and cardiac mortality: what should we worry about and how should the risk be assessed?

Acta psychiatrica Scandinavica 20101101

Exploring the neuroleptic substituent in octoclothepin: potential ligands for positron emission tomography with subnanomolar affinity for α(1)-adrenoceptors.

Journal of medicinal chemistry 20101014

Divergent acute and chronic modulation of glutamatergic postsynaptic density genes expression by the antipsychotics haloperidol and sertindole.

Psychopharmacology 20101001

Validation and pharmacological characterisation of MK-801-induced locomotor hyperactivity in BALB/C mice as an assay for detection of novel antipsychotics.

Psychopharmacology 20101001

Treatment with antipsychotics and the risk of diabetes in clinical practice.

The British journal of psychiatry : the journal of mental science 20101001

Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands.

Bioorganic & medicinal chemistry letters 20100915

Pharmacologic treatment of schizophrenia.

Dialogues in clinical neuroscience 20100901

Antipsychotic drug-induced increases in ventral tegmental area dopamine neuron population activity via activation of the nucleus accumbens-ventral pallidum pathway.

The international journal of neuropsychopharmacology 20100801

Sertindole and fluoxetine overdose with benign outcome.

Nordic journal of psychiatry 20100801

Sertindole and impaired atrioventricular function, in the absence of Q-T prolongation: a case report.

Psychiatry and clinical neurosciences 20100801

The effect of sertindole on QTD and TPTE.

Acta psychiatrica Scandinavica 20100501

Oculogyric crisis with sertindole monotherapy.

Pharmacopsychiatry 20100501

The amiodarone derivative KB130015 activates hERG1 potassium channels via a novel mechanism.

European journal of pharmacology 20100425

Ejaculatory dysfunction in patient with schizophrenia on sertindole.

Psychiatria Danubina 20100301

The European post-marketing observational sertindole study: an investigation of the safety of antipsychotic drug treatment.

European archives of psychiatry and clinical neuroscience 20100201

Zotepine versus other atypical antipsychotics for schizophrenia.

The Cochrane database of systematic reviews 20100120

Mazindol attenuates ketamine-induced cognitive deficit in the attentional set shifting task in rats.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20100101

Sertindole improves sub-chronic PCP-induced reversal learning and episodic memory deficits in rodents: involvement of 5-HT(6) and 5-HT (2A) receptor mechanisms.

Psychopharmacology 20100101

Amisulpride versus other atypical antipsychotics for schizophrenia.

The Cochrane database of systematic reviews 20100101

Quetiapine versus other atypical antipsychotics for schizophrenia.

The Cochrane database of systematic reviews 20100101

First-generation vs second-generation antipsychotic drugs: The ongoing saga.

Indian journal of psychiatry 20100101

QT alterations in psychopharmacology: proven candidates and suspects.

Current drug safety 20100101

Olanzapine versus other atypical antipsychotics for schizophrenia.

The Cochrane database of systematic reviews 20100101

Behavioral and neurobiological changes in C57BL/6 mouse exposed to cuprizone: effects of antipsychotics.

Frontiers in behavioral neuroscience 20100101

New atypical antipsychotics for schizophrenia: iloperidone.

Drug design, development and therapy 20100101

Two four-marker haplotypes on 7q36.1 region indicate that the potassium channel gene HERG1 (KCNH2, Kv11.1) is related to schizophrenia: a case control study.

Behavioral and brain functions : BBF 20100101

Emerging role of sertindole in the management of schizophrenia.

Neuropsychiatric disease and treatment 20100101

Emerging treatments in the management of schizophrenia - focus on sertindole.

Drug design, development and therapy 20100101

Profile of olanzapine long-acting injection for the maintenance treatment of adult patients with schizophrenia.

Neuropsychiatric disease and treatment 20100101

Not all partial dopamine D(2) receptor agonists are the same in treating schizophrenia. Exploring the effects of bifeprunox and aripiprazole using a computer model of a primate striatal dopaminergic synapse.

Neuropsychiatric disease and treatment 20100101

Predictably irrational: assaying cognitive inflexibility in mouse models of schizophrenia.

Frontiers in neuroscience 20100101

Zotepine versus other atypical antipsychotics for schizophrenia.

The Cochrane database of systematic reviews 20100101

Clozapine versus other atypical antipsychotics for schizophrenia.

The Cochrane database of systematic reviews 20100101

Development, clinical utility, and place in therapy of posaconazole for prevention and treatment of invasive fungal infections.

Drug design, development and therapy 20100101

[Cardiovascular risk of haloperidol vs. atypical anti-psychotic drugs in schizophrenia treatment].

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20100101

Metabolic risk in selected second-generation antipsychotics.

Bratislavske lekarske listy 20100101

Translational Aspects of the Novel Object Recognition Task in Rats Abstinent Following Sub-Chronic Treatment with Phencyclidine (PCP): Effects of Modafinil and Relevance to Cognitive Deficits in Schizophrenia.

Frontiers in psychiatry 20100101

Safety and tolerability of antipsychotics: focus on amisulpride.

Drug, healthcare and patient safety 20100101

Stereoselective Inhibition of the hERG1 Potassium Channel.

Frontiers in pharmacology 20100101

Therapeutic drug monitoring of seven psychotropic drugs and four metabolites in human plasma by HPLC-MS.

Journal of pharmaceutical and biomedical analysis 20091205

Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors.

Bioorganic & medicinal chemistry letters 20091201

The comorbidity of diabetes mellitus and psychiatric disorders.

Psychiatria Danubina 20091201

Comparative Analysis of Cognitive Function in Schizophrenia with and without Obsessive Compulsive Disorder.

Psychiatry investigation 20091201

The pNNx Heart Rate Variability Statistics: An Application to Neuroautonomic Dysfunction of Clozapine-Treated Subjects.

Psychiatry investigation 20091201

Mechanisms of action of antipsychotic drugs of different classes, refractoriness to therapeutic effects of classical neuroleptics, and individual variation in sensitivity to their actions: Part I.

Current neuropharmacology 20091201

Mechanisms of action of antipsychotic drugs of different classes, refractoriness to therapeutic effects of classical neuroleptics, and individual variation in sensitivity to their actions: Part II.

Current neuropharmacology 20091201

Reversal of cognitive deficits by an ampakine (CX516) and sertindole in two animal models of schizophrenia--sub-chronic and early postnatal PCP treatment in attentional set-shifting.

Psychopharmacology 20091101

Asenapine effects in animal models of psychosis and cognitive function.

Psychopharmacology 20091101

Sertindole causes distinct electrocardiographic T-wave morphology changes.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20091001

FDG-PET and MRI imaging of the effects of sertindole and haloperidol in the prefrontal lobe in schizophrenia.

Schizophrenia research 20091001

Effect of sertindole on extracellular dopamine, acetylcholine, and glutamate in the medial prefrontal cortex of conscious rats: a comparison with risperidone and exploration of mechanisms involved.

Psychopharmacology 20090901

Iatrogenic QT Abnormalities and Fatal Arrhythmias: Mechanisms and Clinical Significance.

Current cardiology reviews 20090801

Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers.

Journal of medicinal chemistry 20090723

Are weight gain and metabolic side effects of atypical antipsychotics dose dependent? A literature review.

The Journal of clinical psychiatry 20090701

Pharmacokinetics of sertindole and its metabolite dehydrosertindole in rats and characterization of their comparative pharmacodynamics based on in vivo D2 receptor occupancy and behavioural conditioned avoidance response.

Biopharmaceutics & drug disposition 20090501

Further characterization of the discriminative stimulus properties of the atypical antipsychotic drug clozapine in C57BL/6 mice: role of 5-HT(2A) serotonergic and alpha (1) adrenergic antagonism.

Psychopharmacology 20090401

Review of the efficacy of placebo in comparative clinical trials between typical and atypical antipsychotics.

Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) 20090301

Stability of medication in early psychosis: a comparison between second-generation and low-dose first-generation antipsychotics.

Early intervention in psychiatry 20090201

Comparison of haloperidol, risperidone, sertindole, and modafinil to reverse an attentional set-shifting impairment following subchronic PCP administration in the rat--a back translational study.

Psychopharmacology 20090101

Effects of Subchronic Phencyclidine (PCP) Treatment on Social Behaviors, and Operant Discrimination and Reversal Learning in C57BL/6J Mice.

Frontiers in behavioral neuroscience 20090101

Sertindole versus other atypical antipsychotics for schizophrenia.

The Cochrane database of systematic reviews 20090101

Treatment of schizophrenia with antipsychotics in Norwegian emergency wards, a cross-sectional national study.

BMC psychiatry 20090101

Combination therapy or monotherapy for the depressed type of schizoaffective disorder.

Neuropsychiatric disease and treatment 20090101

Maintenance electroconvulsive therapy for comorbid pharmacotherapy-refractory obsessive-compulsive and schizoaffective disorder.

European journal of medical research 20090101

rTMS of the left dorsolateral prefrontal cortex modulates dopamine release in the ipsilateral anterior cingulate cortex and orbitofrontal cortex.

PloS one 20090101

Aripiprazole versus other atypical antipsychotics for schizophrenia.

The Cochrane database of systematic reviews 20090101

Asenapine monotherapy in the acute treatment of both schizophrenia and bipolar I disorder.

Neuropsychiatric disease and treatment 20090101

Measurement of treatment adherence with antipsychotic agents in patients with schizophrenia.

Neuropsychiatric disease and treatment 20090101

Antipsychotics and risk of venous thromboembolism: A population-based case-control study.

Clinical epidemiology 20090101

The antagonistic effect of antipsychotic drugs on a HEK293 cell line stably expressing human alpha1A1-adrenoceptors.

European journal of pharmacology 20081031

Reversal of subchronic PCP-induced deficits in attentional set shifting in rats by sertindole and a 5-HT6 receptor antagonist: comparison among antipsychotics.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20081001

Direct and indirect effects of paliperidone extended-release tablets on negative symptoms of schizophrenia.

Neuropsychiatric disease and treatment 20081001

Effect of sertindole on QTc interval in patients with schizophrenia.

Neuroscience letters 20080905

Do we need another atypical antipsychotic?

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20080801

Orthostatic hypotensive effect of antipsychotic drugs in Wistar rats by in vivo and in vitro studies of alpha1-adrenoceptor function.

Psychopharmacology 20080701

Recruitment of beta-arrestin2 to the dopamine D2 receptor: insights into anti-psychotic and anti-parkinsonian drug receptor signaling.

Neuropharmacology 20080601

Antipsychotics for the treatment of behavioral and psychological symptoms of dementia (BPSD).

Current neuropharmacology 20080601

Dopamine D2(High) receptors moderately elevated by sertindole.

Synapse (New York, N.Y.) 20080501

The Sertindole Cohort Prospective (SCoP) study: rationale, design and methodology.

Pharmacoepidemiology and drug safety 20080501

Sertindole: pharmacological and clinical profile and role in the treatment of schizophrenia.

Expert opinion on drug metabolism & toxicology 20080501

Using pharmacokinetic-pharmacodynamic modelling as a tool for prediction of therapeutic effective plasma levels of antipsychotics.

European journal of pharmacology 20080428

[Trends in psychiatry].

Revue medicale suisse 20080116

Cardiac side effects of psychiatric drugs.

Human psychopharmacology 20080101

Incorporating clinical guidelines through clinician decision-making.

Implementation science : IS 20080101

Evaluation of patients on sertindole treatment after failure of other antipsychotics: a retrospective analysis.

BMC psychiatry 20080101

Associations between venous thromboembolism and antipsychotics. A study of the WHO database of adverse drug reactions.

Drug safety 20080101

The Sertindole Safety Survey: a retrospective analysis under a named patient use programme in Europe.

BMC psychiatry 20080101

The effect of antipsychotic medication on sexual function and serum prolactin levels in community-treated schizophrenic patients: results from the Schizophrenia Trial of Aripiprazole (STAR) study (NCT00237913).

BMC psychiatry 20080101

[Potentially lethal cardiac side effects caused by psychiatric drugs].

Vertex (Buenos Aires, Argentina) 20080101

Current therapeutic options for Alzheimer's disease.

Current genomics 20071201

Course of recovery of cognitive impairment in patients with schizophrenia: a randomised double-blind study comparing sertindole and haloperidol.

Pharmacopsychiatry 20071101

Marked elevation of creatine kinase with sertindole: a case report.

Pharmacopsychiatry 20071101

Pharmacological causes of hyperprolactinemia.

Therapeutics and clinical risk management 20071001

Reversal of PCP-induced learning and memory deficits in the Morris' water maze by sertindole and other antipsychotics.

Psychopharmacology 20070801

Status epilepticus associated with sertindole.

European journal of neurology 20070801

The European sertindole safety and exposure survey: a follow-up study of 8600 patients.

Pharmacoepidemiology and drug safety 20070701

Atypical antipsychotic drugs: current issues of safety and efficacy in the management of schizophrenia.

Current opinion in investigational drugs (London, England : 2000) 20070701

Simultaneous prescribing of atypical antipsychotics, conventional antipsychotics and anticholinergics-a European study.

Pharmacy world & science : PWS 20070601

Antipsychotics for delirium.

The Cochrane database of systematic reviews 20070418

Sertindole: new drug. Another 'atypical' neuroleptic; QT prolongation.

Prescrire international 20070401

Quetiapine in the treatment of schizophrenia and related disorders.

Neuropsychiatric disease and treatment 20070401

An alternative approach to measuring treatment persistence with antipsychotic agents among patients with schizophrenia in the Veterans Health Administration.

Neuropsychiatric disease and treatment 20070401

The use of amisulpride in the treatment of acute psychosis.

Therapeutics and clinical risk management 20070301

Long-acting risperidone injection: efficacy, safety, and cost-effectiveness of the first long-acting atypical antipsychotic.

Neuropsychiatric disease and treatment 20070201

Metabolic drug interactions with newer antipsychotics: a comparative review.

Basic & clinical pharmacology & toxicology 20070101

Metabolic syndrome in Thai schizophrenic patients: a naturalistic one-year follow-up study.

BMC psychiatry 20070101

Clinical pharmacokinetics of atypical antipsychotics: a critical review of the relationship between plasma concentrations and clinical response.

Clinical pharmacokinetics 20070101

Adverse effects of atypical antipsychotics : differential risk and clinical implications.

CNS drugs 20070101

The activity of cytochrome P450 CYP2B in rat liver during neuroleptic treatment.

Pharmacological reports : PR 20070101

Pharmacological treatment of primary negative symptoms in schizophrenia: a systematic review.

Schizophrenia research 20061201

Comparing sertindole to other new generation antipsychotics on preferential dopamine output in limbic versus striatal projection regions: mechanism of action.

Synapse (New York, N.Y.) 20061201

Atypical antipsychotics to treat the neuropsychiatric symptoms of dementia.

Neuropsychiatric disease and treatment 20061201

Beat-to-Beat variability of repolarization determines proarrhythmic outcome in dogs susceptible to drug-induced torsades de pointes.

Journal of the American College of Cardiology 20060919

Chlorpromazine, clozapine and olanzapine inhibit anionic amino acid transport in cultured human fibroblasts.

Amino acids 20060901

Sertindole: efficacy and safety in schizophrenia.

Expert opinion on pharmacotherapy 20060901

Classical as well as novel antipsychotic drugs increase self-stimulation threshold in the rat--similar mechanism of action?

European journal of pharmacology 20060821

Sertindole, in contrast to clozapine and olanzapine, does not disrupt water maze performance after acute or chronic treatment.

European journal of pharmacology 20060807

Effects of antipsychotic drugs on I(to), I (Na), I (sus), I (K1), and hERG: QT prolongation, structure activity relationship, and network analysis.

Pharmaceutical research 20060601

Haloperidol dose when used as active comparator in randomized controlled trials with atypical antipsychotics in schizophrenia: comparison with officially recommended doses.

The Journal of clinical psychiatry 20060601

The use of atypical antipsychotics beyond psychoses: efficacy of quetiapine in bipolar disorder.

Neuropsychiatric disease and treatment 20060601

New insights about HERG blockade obtained from protein modeling, potential energy mapping, and docking studies.

Bioorganic & medicinal chemistry 20060501

Myocardium distribution of sertindole and its metabolite dehydrosertindole in guinea-pigs.

Biopharmaceutics & drug disposition 20060501

Comparative evaluation of HERG currents and QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs.

The Journal of pharmacology and experimental therapeutics 20060301

The German Research Network on Schizophrenia--impact on the management of schizophrenia.

Dialogues in clinical neuroscience 20060301

A dopaminergic deficit hypothesis of schizophrenia: the path to discovery.

Dialogues in clinical neuroscience 20060301

The effectiveness of atypical antipsychotics for the treatment of aggression and psychosis in Alzheimer's disease.

The Cochrane database of systematic reviews 20060125

A double-blind, controlled study of sertindole versus risperidone in the treatment of moderate-to-severe schizophrenia.

International clinical psychopharmacology 20060101

Sertindole : a review of its use in schizophrenia.

CNS drugs 20060101

Pharmacological treatment of ambulatory schizophrenic patients in Belgium.

Clinical practice and epidemiology in mental health : CP & EMH 20060101

QTc interval prolongation and antipsychotic drug treatments: focus on sertindole.

The international journal of neuropsychopharmacology 20051201

Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist.

The Journal of pharmacology and experimental therapeutics 20051201

Adjunctive treatment with mianserin enhances effects of raclopride on cortical dopamine output and, in parallel, its antipsychotic-like effect.

Neuropsychiatric disease and treatment 20051201

Generalization to atypical antipsychotic drugs depends on training dose in rats trained to discriminate 1.25 mg/kg clozapine versus 5.0 mg/kg clozapine versus vehicle in a three-choice drug discrimination task.

Behavioural pharmacology 20051101

Treatment with the new antipsychotic sertindole for late-occurring undesirable movement effects.

International clinical psychopharmacology 20051101

Atypical antipsychotics produce within-session decrements on self-stimulation of the rat medial prefrontal cortex.

Frontiers in bioscience : a journal and virtual library 20050901

Comparison of methanol and acetonitrile as solvents for the separation of sertindole and its major metabolites by capillary zone electrophoresis.

Electrophoresis 20050901

Adjunctive treatment with mianserin enhances effects of raclopride on cortical dopamine output and, in parallel, its antipsychotic-like effect.

Neuropsychiatric disease and treatment 20050901

Sertindole for schizophrenia.

The Cochrane database of systematic reviews 20050720

Current therapy issues and unmet clinical needs in the treatment of schizophrenia: a review of the new generation antipsychotics.

International clinical psychopharmacology 20050701

Exploring blocker binding to a homology model of the open hERG K+ channel using docking and molecular dynamics methods.

FEBS letters 20050523

Antipsychotics lack alpha 1A/B adrenoceptor subtype selectivity in the rat.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20050301

Simplified ultraviolet liquid chromatographic method for determination of sertindole, dehydrosertindole and norsertindole, in human plasma.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050105

Inhibition of rat liver CYP2D in vitro and after 1-day and long-term exposure to neuroleptics in vivo-possible involvement of different mechanisms.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20050101

Atypical antipsychotics: from potassium channels to torsade de pointes and sudden death.

Drug safety 20050101

Unbiased descriptor and parameter selection confirms the potential of proteochemometric modelling.

BMC bioinformatics 20050101

Choice of cardiac tissue plays an important role in the evaluation of drug-induced prolongation of the QT interval in vitro in rabbit.

Journal of pharmacological and toxicological methods 20050101

Hostility and violence of acute psychiatric inpatients.

Clinical practice and epidemiology in mental health : CP & EMH 20050101

Neuropsychological measures of attention and memory function in schizophrenia: relationships with symptom dimensions and serum monoamine activity.

Behavioral and brain functions : BBF 20050101

Direct effects of neuroleptics on the activity of CYP2A in the liver of rats.

Pharmacological reports : PR 20050101

Interactions between neuroleptics and CYP2C6 in rat liver--in vitro and ex vivo study.

Pharmacological reports : PR 20050101

Clinical observations of sertindole in 53 hospitalised patients with psychotic disorders.

Clinical drug investigation 20050101

Possible induction of mania or hypomania by atypical antipsychotics: an updated review of reported cases.

The Journal of clinical psychiatry 20041101

[Psychotropics and weight gain].

Praxis 20040825

Determination of myocardium to plasma concentration ratios of five antipsychotic drugs: comparison with their ability to induce arrhythmia and sudden death in clinical practice.

Toxicology and applied pharmacology 20040815

Evidence-based pharmacotherapy of schizophrenia.

The international journal of neuropsychopharmacology 20040601

New alpha(1)-adrenoceptor antagonists derived from the antipsychotic sertindole - carbon-11 labelling and pet examination of brain uptake in the cynomolgus monkey.

Nuclear medicine and biology 20040401

Selective optimization of side activities: another way for drug discovery.

Journal of medicinal chemistry 20040311

Treatment-refractory schizophrenia.

Dialogues in clinical neuroscience 20040301

Differing response to antipsychotic therapy in schizophrenia: pharmacogenomic aspects.

Dialogues in clinical neuroscience 20040301

Sex-dependent modulation of treatment response.

Dialogues in clinical neuroscience 20040301

Atypical antipsychotics: pharmacokinetics, therapeutic drug monitoring and pharmacological interactions.

Current medicinal chemistry 20040201

[Current pharmacotherapy of schizophrenia].

Orvosi hetilap 20040118

Cardiovascular side effects of new antidepressants and antipsychotics: new drugs, old concerns?

Current pharmaceutical design 20040101

Introduction to sertindole in clinical practice.

CNS drugs 20040101

A review of the efficacy, tolerability and safety of sertindole in clinical trials.

CNS drugs 20040101

Case histories illustrating the utility of sertindole in clinical practice.

CNS drugs 20040101

Impact of atypical antipsychotics on quality of life in patients with schizophrenia.

CNS drugs 20040101

Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia.

British journal of cancer 20031117

Electrophysiological safety of sertindole in dogs with normal and remodeled hearts.

The Journal of pharmacology and experimental therapeutics 20031101

Enhancement of latent inhibition by two 5-HT2A receptor antagonists only when given at both pre-exposure and conditioning.

Psychopharmacology 20030901

Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.

Bioorganic & medicinal chemistry letters 20030818

Antipsychotic medication and seizures: a review.

Drugs of today (Barcelona, Spain : 1998) 20030701

Alpha(1) adrenoceptor subtype selectivity. 3D-QSAR models for a new class of alpha(1) adrenoceptor antagonists derived from the novel antipsychotic sertindole.

Journal of molecular graphics & modelling 20030601

Biases affecting the proportional reporting ratio (PPR) in spontaneous reports pharmacovigilance databases: the example of sertindole.

Pharmacoepidemiology and drug safety 20030601

Dealing with uncertainty in drug safety: lessons for the future from sertindole.

Pharmacoepidemiology and drug safety 20030601

The relevance of prolonged QTc measurement to pediatric psychopharmacology.

Journal of the American Academy of Child and Adolescent Psychiatry 20030601

Understanding the structure-activity relationship of the human ether-a-go-go-related gene cardiac K+ channel. A model for bad behavior.

Journal of medicinal chemistry 20030522

Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches.

Bioorganic & medicinal chemistry letters 20030519

New generation antipsychotics versus low-potency conventional antipsychotics: a systematic review and meta-analysis.

Lancet (London, England) 20030510

Synthesis and structure-affinity relationship investigations of 5-aminomethyl and 5-carbamoyl analogues of the antipsychotic sertindole. A new class of selective alpha1 adrenoceptor antagonists.

Bioorganic & medicinal chemistry 20030320

H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030301

Detection of proarrhythmia in the female rabbit heart: blinded validation.

Journal of cardiovascular electrophysiology 20030301

Synthesis and structure-affinity relationship investigations of 5-heteroaryl-substituted analogues of the antipsychotic sertindole. A new class of highly selective alpha(1) adrenoceptor antagonists.

Journal of medicinal chemistry 20030116

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology 20030101

QTc prolongation due to propranolol overdose.

International journal of psychiatry in medicine 20030101

Influence of classic and atypical neuroleptics on caffeine oxidation in rat liver microsomes.

Polish journal of pharmacology 20030101

The potential cardiotoxicity of antipsychotic drugs as assessed by heart rate variability.

Journal of psychopharmacology (Oxford, England) 20021201

Development of neuroleptic agents: pharmacogenetics and current safety issues of regulatory concern.

Dialogues in clinical neuroscience 20021201

Optimizing dosing in atypical neuroleptic monotherapy.

Dialogues in clinical neuroscience 20021201

Obesity and related metabolic abnormalities during antipsychotic drug administration: mechanisms, management and research perspectives.

Pharmacopsychiatry 20021101

A comparison of the receptor binding and HERG channel affinities for a series of antipsychotic drugs.

European journal of pharmacology 20020816

Stimulation by antipsychotic agents of mitogen-activated protein kinase (MAPK) coupled to cloned, human (h)serotonin (5-HT)(1A) receptors.

Psychopharmacology 20020701

Low striatal and extra-striatal D2 receptor occupancy during treatment with the atypical antipsychotic sertindole.

Psychopharmacology 20020601

Striatal dopamine-2 receptor occupancy as measured with [123I]iodobenzamide and SPECT predicted the occurrence of EPS in patients treated with atypical antipsychotics and haloperidol.

Psychopharmacology 20020601

Variations in prescribing atypical antipsychotic drugs in primary care: cross-sectional study.

Pharmacoepidemiology and drug safety 20020601

Psychotropic drugs and the ECG: focus on the QTc interval.

Expert opinion on pharmacotherapy 20020501

Effects of the 5-HT(6) receptor antagonist, SB-271046, in animal models for schizophrenia.

Pharmacology, biochemistry, and behavior 20020401

Effects of antipsychotic drugs on operant responding after acute and repeated administration.

Psychopharmacology 20020301

Schizophrenia: genesis, receptorology and current therapeutics.

Current medicinal chemistry 20020301

Atypical antipsychotics: mechanism of action.

Canadian journal of psychiatry. Revue canadienne de psychiatrie 20020201

Electrophysiologic characterization of the antipsychotic drug sertindole in a rabbit heart model of torsade de pointes: low torsadogenic potential despite QT prolongation.

The Journal of pharmacology and experimental therapeutics 20020101

Antipsychotic-related QTc prolongation, torsade de pointes and sudden death.

Drugs 20020101

[Relationship between clozapine plasma levels and withdrawal symptoms].

Actas espanolas de psiquiatria 20020101

Investigation of the potential of clozapine to cause torsade de pointes.

Adverse drug reactions and toxicological reviews 20020101

[Schizoaffective disorder: clinical symptoms and present-day approach to treatment].

Medicina (Kaunas, Lithuania) 20020101

Agonist, antagonist, and inverse agonist properties of antipsychotics at human recombinant 5-HT(1A) receptors expressed in HeLa cells.

European journal of pharmacology 20011214

Novel antipsychotics and acute dystonic reactions.

The international journal of neuropsychopharmacology 20011201

Treatments for chronic psychosis.

Dialogues in clinical neuroscience 20011201

Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death.

The American journal of psychiatry 20011101

Development and evaluation of high throughput functional assay methods for HERG potassium channel.

Journal of biomolecular screening 20011001

Sertindole is a serotonin 5-HT2c inverse agonist and decreases agonist but not antagonist binding to 5-HT2c receptors after chronic treatment.

Psychopharmacology 20010901

The antipsychotic drugs sertindole and pimozide block erg3, a human brain K(+) channel.

Biochemical and biophysical research communications 20010824

Effects of acute versus chronic treatment with typical or atypical antipsychotics on d-amphetamine-induced sensorimotor gating deficits in rats.

Psychopharmacology 20010701

Comparative study of mortality rates and cardiac dysrhythmias in post-marketing surveillance studies of sertindole and two other atypical antipsychotic drugs, risperidone and olanzapine.

Journal of psychopharmacology (Oxford, England) 20010601

Recent developments in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress.

Journal of medicinal chemistry 20010524

The canine Purkinje fiber: an in vitro model system for acquired long QT syndrome and drug-induced arrhythmogenesis.

Journal of cardiovascular pharmacology 20010501

The muscarinic receptor agonist BuTAC, a novel potential antipsychotic, does not impair learning and memory in mouse passive avoidance.

Schizophrenia research 20010415

Traditional and new antipsychotic drugs differentially alter neurotransmission markers in basal ganglia-thalamocortical neural pathways.

Synapse (New York, N.Y.) 20010201

Effects of newer atypical antipsychotics on autonomic neurocardiac function: a comparison between amisulpride, olanzapine, sertindole, and clozapine.

Journal of clinical psychopharmacology 20010201

Atypical antipsychotics: new directions and new challenges in the treatment of schizophrenia.

Annual review of medicine 20010101

Cost effectiveness of the newer atypical antipsychotics: a review of the pharmacoeconomic research evidence.

Current opinion in investigational drugs (London, England : 2000) 20010101

Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxytryptamine2C receptors.

The Journal of pharmacology and experimental therapeutics 20001001

Quinpirole, 8-OH-DPAT and ketanserin modulate catalepsy induced by high doses of atypical antipsychotics.

Methods and findings in experimental and clinical pharmacology 19991101

Efficacy and extrapyramidal side-effects of the new antipsychotics olanzapine, quetiapine, risperidone, and sertindole compared to conventional antipsychotics and placebo. A meta-analysis of randomized controlled trials.

Schizophrenia research 19990104

Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study.

European journal of pharmacology 19980821

Antipsychotic drugs which elicit little or no parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors.

Molecular psychiatry 19980301

Do novel antipsychotics have similar pharmacological characteristics? A review of the evidence.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 19980201

Sertindole (Serdolect): preclinical and clinical findings of a new atypical antipsychotic.

Expert opinion on investigational drugs 19971101

[Sertindole, a novel alpha 1A-adrenoceptor selective antagonist].

Yao xue xue bao = Acta pharmaceutica Sinica 19970701

Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptors.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 19970201

Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding.

Psychopharmacology 19960301

Differential effects of classical and newer antipsychotics on the hypermotility induced by two dose levels of D-amphetamine.

European journal of pharmacology 19950905

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