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10596-23-3 | (Dichloromethylene)diphosphonic acid
CAS No: 10596-23-3 Catalog No: AG0039PT MDL No:MFCD00867075
Product Description
Catalog Number:
AG0039PT
Chemical Name:
(Dichloromethylene)diphosphonic acid
CAS Number:
10596-23-3
Molecular Formula:
CH4Cl2O6P2
Molecular Weight:
244.8924
MDL Number:
MFCD00867075
IUPAC Name:
[dichloro(phosphono)methyl]phosphonic acid
InChI:
InChI=1S/CH4Cl2O6P2/c2-1(3,10(4,5)6)11(7,8)9/h(H2,4,5,6)(H2,7,8,9)
InChI Key:
ACSIXWWBWUQEHA-UHFFFAOYSA-N
SMILES:
ClC(P(=O)(O)O)(P(=O)(O)O)Cl
EC Number:
234-212-1
UNII:
0813BZ6866
Properties
Complexity:
211
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
243.886g/mol
Formal Charge:
0
Heavy Atom Count:
11
Hydrogen Bond Acceptor Count:
6
Hydrogen Bond Donor Count:
4
Isotope Atom Count:
0
Molecular Weight:
244.885g/mol
Monoisotopic Mass:
243.886g/mol
Rotatable Bond Count:
2
Topological Polar Surface Area:
115A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-2.1
Literature
| Title | Journal |
|---|---|
| Modulation of paraoxonase 1 (PON1) activity and protein N-homocysteinylation by bisphosphonates in rats. | Chemico-biological interactions 20161125 |
| Toll-like Receptor 4 on Macrophage Promotes the Development of Steatohepatitis-related Hepatocellular Carcinoma in Mice. | The Journal of biological chemistry 20160527 |
| Depletion of Hepatic Macrophages Aggravates Liver Lesions Induced in Rats by Thioacetamide (TAA). | Toxicologic pathology 20160201 |
| Transcriptomics hit the target: Monitoring of ligand-activated and stress response pathways for chemical testing. | Toxicology in vitro : an international journal published in association with BIBRA 20151225 |
| Dopamine induces growth inhibition and vascular normalization through reprogramming M2-polarized macrophages in rat C6 glioma. | Toxicology and applied pharmacology 20150715 |
| Crucial role of macrophage selenoproteins in experimental colitis. | Journal of immunology (Baltimore, Md. : 1950) 20141001 |
| Hepatic stellate cells orchestrate clearance of necrotic cells in a hypoxia-inducible factor-1α-dependent manner by modulating macrophage phenotype in mice. | Journal of immunology (Baltimore, Md. : 1950) 20140415 |
| Macrophage TNF-α mediates parathion-induced airway hyperreactivity in guinea pigs. | American journal of physiology. Lung cellular and molecular physiology 20130415 |
| Kupffer cell depletion attenuates leptin-mediated methoxamine-stimulated portal perfusion pressure and thromboxane A2 release in a rodent model of NASH-cirrhosis. | Clinical science (London, England : 1979) 20121201 |
| Effective delivery of chemotherapeutic nanoparticles by depleting host Kupffer cells. | International journal of cancer 20121115 |
| CD11c(+)/CD11b(+) cells are critical for organic dust-elicited murine lung inflammation. | American journal of respiratory cell and molecular biology 20121101 |
| Macrophage/monocyte depletion by clodronate, but not diphtheria toxin, improves renal ischemia/reperfusion injury in mice. | Kidney international 20121001 |
| Monocytes control second-phase neutrophil emigration in established lipopolysaccharide-induced murine lung injury. | American journal of respiratory and critical care medicine 20120915 |
| Effects of low-dose doxycycline and bisphosphonate clodronate on alveolar bone loss and gingival levels of matrix metalloproteinase-9 and interleukin-1β in rats with diabetes: a histomorphometric and immunohistochemical study. | Journal of periodontology 20120901 |
| Methylenebisphosphonate and triphosphate derivatives of the mevalonate pathway are substrates of yeast UTP:glucose-1-phosphate uridylyltransferase. | Biochimie 20120901 |
| Critical involvement of macrophage infiltration in the development of Sjögren's syndrome-associated dry eye. | The American journal of pathology 20120901 |
| Adjuvant bone-targeted therapy to prevent metastasis: lessons from the AZURE study. | Current opinion in supportive and palliative care 20120901 |
| The effect of the combination of bisphosphonates and conventional chemotherapy on bone metabolic markers in multiple myeloma patients. | Hematology (Amsterdam, Netherlands) 20120901 |
| Clinical trials of bisphosphonates in multiple myeloma. | Clinical advances in hematology & oncology : H&O 20120901 |
| Effect of alendronate for reducing fracture by FRAX score and femoral neck bone mineral density: the Fracture Intervention Trial. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20120801 |
| Breast cancer cell targeting by prenylation inhibitors elucidated in living animals with a bioluminescence reporter. | Clinical cancer research : an official journal of the American Association for Cancer Research 20120801 |
| Interpreting results from oncology clinical trials: a comparison of denosumab to zoledronic acid for the prevention of skeletal-related events in cancer patients. | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20120701 |
| Treatment of chronic hypercalcemia. | Medicinal chemistry (Shariqah (United Arab Emirates)) 20120701 |
| Bisphosphonates in early breast cancer. | The Lancet. Oncology 20120701 |
| Oral clodronate for adjuvant treatment of operable breast cancer (National Surgical Adjuvant Breast and Bowel Project protocol B-34): a multicentre, placebo-controlled, randomised trial. | The Lancet. Oncology 20120701 |
| Nanoparticle-based clodronate delivery mitigates murine experimental colitis. | Journal of controlled release : official journal of the Controlled Release Society 20120628 |
| Chimeric antigen receptor T cells shape myeloid cell function within the tumor microenvironment through IFN-γ and GM-CSF. | Journal of immunology (Baltimore, Md. : 1950) 20120615 |
| Effects of induction and maintenance plus long-term bisphosphonates on bone disease in patients with multiple myeloma: the Medical Research Council Myeloma IX Trial. | Blood 20120607 |
| Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2. | American journal of physiology. Gastrointestinal and liver physiology 20120601 |
| Mice lacking macrophage 12/15-lipoxygenase are resistant to experimental hypertension. | American journal of physiology. Heart and circulatory physiology 20120601 |
| The maintenance of lymphatic vessels in the cornea is dependent on the presence of macrophages. | Investigative ophthalmology & visual science 20120531 |
| The location of splenic NKT cells favours their rapid activation by blood-borne antigen. | The EMBO journal 20120516 |
| Bisphosphonates in multiple myeloma: a network meta-analysis. | The Cochrane database of systematic reviews 20120516 |
| Caspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis. | Laboratory investigation; a journal of technical methods and pathology 20120501 |
| Inhibitory effect of novel S,N-bisphosphonates on some carcinoma cell lines, osteoarthritis, and chronic inflammation. | European journal of medicinal chemistry 20120501 |
| RhoGDI2 suppresses lung metastasis in mice by reducing tumor versican expression and macrophage infiltration. | The Journal of clinical investigation 20120402 |
| Clodronate and hydroxychloroquine in erosive osteoarthritis: a 24-month open randomized pilot study. | Modern rheumatology 20120401 |
| Microglial depletion using intrahippocampal injection of liposome-encapsulated clodronate in prolonged hypothermic cardiac arrest in rats. | Resuscitation 20120401 |
| Bisphosphonates as antimyeloma drugs. | Leukemia 20120401 |
| Patient-reported outcome instruments used to assess pain and functioning in studies of bisphosphonate treatment for bone metastases. | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20120401 |
| Cutting edge: nitrogen bisphosphonate-induced inflammation is dependent upon mast cells and IL-1. | Journal of immunology (Baltimore, Md. : 1950) 20120401 |
| NASH is an Inflammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications. | Gut and liver 20120401 |
| Maintenance of antifracture efficacy over 10 years with strontium ranelate in postmenopausal osteoporosis. | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20120301 |
| Osteoclasts derived from patients with neurofibromatosis 1 (NF1) display insensitivity to bisphosphonates in vitro. | Bone 20120301 |
| Bisphosphonates significantly increase the activity of doxorubicin or vincristine against canine malignant histiocytosis cells. | Veterinary and comparative oncology 20120301 |
| Effect of dosing interval duration of intermittent ibandronate treatment on the healing process of femoral osteotomy in a rat fracture model. | Calcified tissue international 20120301 |
| Differential detection and distribution of microglial and hematogenous macrophage populations in the injured spinal cord of lys-EGFP-ki transgenic mice. | Journal of neuropathology and experimental neurology 20120301 |
| Current recommendations for laboratory testing and use of bone turnover markers in management of osteoporosis. | Annals of laboratory medicine 20120301 |
| Replacement of microglial cells using Clodronate liposome and bone marrow transplantation in the central nervous system of SOD1(G93A) transgenic mice as an in vivo model of amyotrophic lateral sclerosis. | Biochemical and biophysical research communications 20120210 |
| Influence of bisphosphonates on the osteoblast RANKL and OPG gene expression in vitro. | Clinical oral investigations 20120201 |
| The influence of bisphosphonates on viability, migration, and apoptosis of human oral keratinocytes--in vitro study. | Clinical oral investigations 20120201 |
| Bisphosphonates and breast cancer prevention. | Anti-cancer agents in medicinal chemistry 20120201 |
| The Medical Research Council Myeloma IX Trial: new clinical insights on the anticancer effects of zoledronic acid in patients with multiple myeloma. | Clinical lymphoma, myeloma & leukemia 20120201 |
| Immunology in the clinic review series; focus on cancer: tumour-associated macrophages: undisputed stars of the inflammatory tumour microenvironment. | Clinical and experimental immunology 20120201 |
| Depletion of macrophages and dendritic cells in ischemic acute kidney injury. | American journal of nephrology 20120201 |
| Extraskeletal benefits and risks of calcium, vitamin D and anti-osteoporosis medications. | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20120201 |
| Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice. | Nature communications 20120131 |
| Depletion of alveolar macrophages prolongs survival in response to acute pneumovirus infection. | Virology 20120120 |
| The Medical Research Council Myeloma IX trial: the impact on treatment paradigms. | European journal of haematology 20120101 |
| P-selectin glycoprotein ligand-1 deficiency leads to cytokine resistance and protection against atherosclerosis in apolipoprotein E deficient mice. | Atherosclerosis 20120101 |
| Development of an injectable two-phase drug delivery system for sequential release of antiresorptive and osteogenic drugs. | Journal of biomedical materials research. Part B, Applied biomaterials 20120101 |
| Still's Disease and Recurrent Complex Regional Pain Syndrome Type-I: The First Description. | Autoimmune diseases 20120101 |
| Exposure to bisphosphonates and risk of cancer: a protocol for nested case-control studies using the QResearch primary care database. | BMJ open 20120101 |
| Genetically-engineered pig-to-baboon liver xenotransplantation: histopathology of xenografts and native organs. | PloS one 20120101 |
| Constitutive activity of NF-kappa B in myeloid cells drives pathogenicity of monocytes and macrophages during autoimmune neuroinflammation. | Journal of neuroinflammation 20120101 |
| Effect of oral clodronate on structural damage and bone turnover in rheumatoid arthritis. | Clinical and experimental rheumatology 20120101 |
| Nanomedicine for glaucoma: liposomes provide sustained release of latanoprost in the eye. | International journal of nanomedicine 20120101 |
| Adoptive transfer of IL-4Rα+ macrophages is sufficient to enhance eosinophilic inflammation in a mouse model of allergic lung inflammation. | BMC immunology 20120101 |
| A novel role for microglia in minimizing excitotoxicity. | BMC biology 20120101 |
| Neuroprotective function for ramified microglia in hippocampal excitotoxicity. | Journal of neuroinflammation 20120101 |
| Deciphering the Multifaceted Relationship between Oncolytic Viruses and Natural Killer Cells. | Advances in virology 20120101 |
| Cost-effectiveness of zoledronic acid vs clodronic acid for newly-diagnosed multiple myeloma from the United Kingdom healthcare system perspective. | Journal of medical economics 20120101 |
| Therapeutic application of natural inhibitors against snake venom phospholipase A(2). | Bioinformation 20120101 |
| Systemic delivery of oncolytic viruses: hopes and hurdles. | Advances in virology 20120101 |
| Host genetics and Chlamydia disease: prediction and validation of disease severity mechanisms. | PloS one 20120101 |
| Giant cell tumors of the axial skeleton. | Sarcoma 20120101 |
| Smoking and idiopathic pulmonary fibrosis. | Pulmonary medicine 20120101 |
| Complexity of the microglial activation pathways that drive innate host responses during lethal alphavirus encephalitis in mice. | ASN neuro 20120101 |
| Could a B-1 cell derived phagocyte 'be one' of the peritoneal macrophages during LPS-driven inflammation? | PloS one 20120101 |
| Oval cell response is attenuated by depletion of liver resident macrophages in the 2-AAF/partial hepatectomy rat. | PloS one 20120101 |
| Chemically modified tetracyclines: Novel therapeutic agents in the management of chronic periodontitis. | Indian journal of pharmacology 20120101 |
| NK cells promote Th-17 mediated corneal barrier disruption in dry eye. | PloS one 20120101 |
| VIP deficient mice exhibit resistance to lipopolysaccharide induced endotoxemia with an intrinsic defect in proinflammatory cellular responses. | PloS one 20120101 |
| Osteonecrosis of jaw associated with bisphosphonate use. | Indian journal of endocrinology and metabolism 20120101 |
| Liposomal clodronate selectively eliminates microglia from primary astrocyte cultures. | Journal of neuroinflammation 20120101 |
| Preparation and evaluation of polymeric microparticulates for improving cellular uptake of gemcitabine. | International journal of nanomedicine 20120101 |
| Remarkable regression of an osteolytic lesion of large cell lung cancer treated with zoledronic Acid: a case report. | Case reports in oncology 20120101 |
| Mortality and implant revision rates of hip arthroplasty in patients with osteoarthritis: registry based cohort study. | BMJ (Clinical research ed.) 20120101 |
| Accumulating microglia phagocytose injured neurons in hippocampal slice cultures: involvement of p38 MAP kinase. | PloS one 20120101 |
| Depletion and reconstitution of macrophages in mice. | Journal of visualized experiments : JoVE 20120101 |
| The reactivity, distribution and abundance of Non-astrocytic Inner Retinal Glial (NIRG) cells are regulated by microglia, acute damage, and IGF1. | PloS one 20120101 |
| Renal IL-18 production is macrophage independent during obstructive injury. | PloS one 20120101 |
| In vivo imaging implicates CCR2(+) monocytes as regulators of neutrophil recruitment during arthritis. | Cellular immunology 20120101 |
| Zoledronate, ibandronate and clodronate enhance osteoblast differentiation in a dose dependent manner--a quantitative in vitro gene expression analysis of Dlx5, Runx2, OCN, MSX1 and MSX2. | Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery 20111201 |
| A critical role for macrophages in neovessel formation and the development of stenosis in tissue-engineered vascular grafts. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20111201 |
| Kupffer cell depletion prevents but has no therapeutic effect on metabolic and inflammatory changes induced by a high-fat diet. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20111201 |
| Occurrence of gastrointestinal cancer in users of bisphosphonates and other antiresorptive drugs against osteoporosis. | Calcified tissue international 20111201 |
| A critical role for macrophages in promotion of urethane-induced lung carcinogenesis. | Journal of immunology (Baltimore, Md. : 1950) 20111201 |
| Preventive effects of zoledronic acid on bone metastasis in mice injected with human breast cancer cells. | Journal of Korean medical science 20111201 |
| Tissue tropism and target cells of NSs-deleted rift valley fever virus in live immunodeficient mice. | PLoS neglected tropical diseases 20111201 |
| Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). | PLoS computational biology 20111201 |
| Effects of Sigma Anti-bonding Molecule Calcium Carbonate on bone turnover and calcium balance in ovariectomized rats. | Laboratory animal research 20111201 |
| Adjuvant Effect of IV Clodronate on the Delay of Bone Metastasis in High-Risk Prostate Cancer Patients: A Prospective Study. | Cancer research and treatment : official journal of Korean Cancer Association 20111201 |
| Microglia-mediated IGF-I neuroprotection in the rd10 mouse model of retinitis pigmentosa. | Investigative ophthalmology & visual science 20111125 |
| Monocyte/macrophages promote vasculogenesis in choroidal neovascularization in mice by stimulating SDF-1 expression in RPE cells. | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20111101 |
| Economic evaluation of clodronate and zoledronate in patients diagnosed with metastatic bone disease from the perspective of public and third party payors in Brazil. | Clinical therapeutics 20111101 |
| Evaluation of the role of tumor-associated macrophages in an experimental model of peritoneal carcinomatosis using (18)F-FDG PET. | Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20111101 |
| The critical role of Notch ligand Delta-like 1 in the pathogenesis of influenza A virus (H1N1) infection. | PLoS pathogens 20111101 |
| CD11b⁺, Ly6G⁺ cells produce type I interferon and exhibit tissue protective properties following peripheral virus infection. | PLoS pathogens 20111101 |
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| Effects of liposome-encapsulated clodronate on chlorhexidine gluconate-induced peritoneal fibrosis in rats. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20111001 |
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| Effects of antiresorptive treatment on nonvertebral fracture outcomes. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20111001 |
| Glycyrrhizin prevents liver injury by inhibition of high-mobility group box 1 production by Kupffer cells after ischemia-reperfusion in rats. | The Journal of pharmacology and experimental therapeutics 20111001 |
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| Macrophages promote cyst growth in polycystic kidney disease. | Journal of the American Society of Nephrology : JASN 20111001 |
| Bisphosphonate-related osteonecrosis of the jaws associated with photodynamic therapy. | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20111001 |
| Protective effect of clodronate-containing liposomes on intestinal mucosal injury in rats with severe acute pancreatitis. | Hepatobiliary & pancreatic diseases international : HBPD INT 20111001 |
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| Myopia and inflammation. | Journal of ophthalmic & vision research 20111001 |
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| Toll-like receptor 4 knockout mice are protected from endothelial overactivation in the absence of Kupffer cells after total hepatic ischemia/reperfusion. | Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20110901 |
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| CD8- dendritic cells and macrophages cross-present poly(D,L-lactate-co-glycolate) acid microsphere-encapsulated antigen in vivo. | Journal of immunology (Baltimore, Md. : 1950) 20110901 |
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| The influence of macrophage depletion on ligament healing. | Connective tissue research 20110601 |
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| Marginal zone macrophages suppress innate and adaptive immunity to apoptotic cells in the spleen. | Blood 20110519 |
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| Macrophage-derived tumor necrosis factor-alpha is an early component of the molecular cascade leading to angiogenesis in response to aortic injury. | Arteriosclerosis, thrombosis, and vascular biology 20110501 |
| Fluorimetric quantification of clodronate and alendronate in aqueous samples and in serum. | Talanta 20110415 |
| Three cases of bone metastases in patients with gastrointestinal stromal tumors. | Rare tumors 20110404 |
| Stroke in relation to use of raloxifene and other drugs against osteoporosis. | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20110401 |
| Optimized electro- and wet-spinning techniques for the production of polymeric fibrous scaffolds loaded with bisphosphonate and hydroxyapatite. | Journal of tissue engineering and regenerative medicine 20110401 |
| Depletion of antigen-presenting cells by clodronate liposomes reverses the psoriatic skin phenotype in KC-Tie2 mice. | The British journal of dermatology 20110401 |
| Positive correlation between the generation of reactive oxygen species and activation/reactivation of transgene expression after hydrodynamic injections into mice. | Pharmaceutical research 20110401 |
| Role of matrix metalloproteinases and therapeutic benefits of their inhibition in spinal cord injury. | Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20110401 |
| Brain infiltration of leukocytes contributes to the pathophysiology of temporal lobe epilepsy. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20110316 |
| The roles of vitreal macrophages and circulating leukocytes in retinal neovascularization. | Investigative ophthalmology & visual science 20110314 |
| Targeting adenovirus gene delivery to activated tumour-associated vasculature via endothelial selectins. | Journal of controlled release : official journal of the Controlled Release Society 20110310 |
| Osteonecrosis of the posterior mandible after implant insertion: a clinical and histological case report. | Clinical implant dentistry and related research 20110301 |
| Can clodronate be effective in the treatment of disabling hydroxyapatite crystal-deposition disease? A report of two cases. | Rheumatology international 20110301 |
| Bisphosphonates affect migration ability and cell viability of HUVEC, fibroblasts and osteoblasts in vitro. | Oral diseases 20110301 |
| Risk of femoral shaft and subtrochanteric fractures among users of bisphosphonates and raloxifene. | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20110301 |
| Multiple helminth infection of the skin causes lymphocyte hypo-responsiveness mediated by Th2 conditioning of dermal myeloid cells. | PLoS pathogens 20110301 |
| Depletion of alveolar macrophages abrogates prolongation of cardiac allograft survival induced by intratracheal delivery of alloantigen. | Transplantation 20110227 |
| Muramyldipeptide augments the actions of lipopolysaccharide in mice by stimulating macrophages to produce pro-IL-1β and by down-regulation of the suppressor of cytokine signaling 1 (SOCS1). | Innate immunity 20110201 |
| Bisphosphonates: restrictions for vasculogenesis and angiogenesis: inhibition of cell function of endothelial progenitor cells and mature endothelial cells in vitro. | Clinical oral investigations 20110201 |
| Macrophage-produced IL-12p70 mediates hemorrhage-induced damage in a complement-dependent manner. | Shock (Augusta, Ga.) 20110201 |
| Interaction of clodronate with fibroblast growth factor 2 reduces FGF2-activity in endothelial cells. | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20110201 |
| Functional redundancy between thymic CD8α+ and Sirpα+ conventional dendritic cells in presentation of blood-derived lysozyme by MHC class II proteins. | Journal of immunology (Baltimore, Md. : 1950) 20110201 |
| Bisphosphonates inhibit phosphorylation of signal transducer and activator of transcription 3 and expression of suppressor of cytokine signaling 3: implications for their effects on innate immune function and osteoclastogenesis. | Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20110201 |
| Steady state pharmacokinetics and dose equivalents of oral clodronate in renal failure. | International journal of clinical pharmacology and therapeutics 20110201 |
| The role of the radiologist when encountering osteoporosis in women. | AJR. American journal of roentgenology 20110201 |
| Octacalcium phosphate crystals induce inflammation in vivo through interleukin-1 but independent of the NLRP3 inflammasome in mice. | Arthritis and rheumatism 20110201 |
| Established role of bisphosphonate therapy for prevention of skeletal complications from myeloma bone disease. | Critical reviews in oncology/hematology 20110201 |
| Can bisphosphonates improve outcomes in patients with newly diagnosed multiple myeloma? | Critical reviews in oncology/hematology 20110201 |
| Effects of ibandronate-hydroxyapatite on resorptive activity of osteoclasts. | Archives of medical science : AMS 20110201 |
| HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF. | Cancer cell 20110118 |
| Effects of two administration schemes of intramuscular clodronic acid on bone mineral density: a randomized, open-label, parallel-group study. | Clinical drug investigation 20110101 |
| TGF-beta driven lung fibrosis is macrophage dependent and blocked by Serum amyloid P. | The international journal of biochemistry & cell biology 20110101 |
| Computational insights into binding of bisphosphates to farnesyl pyrophosphate synthase. | Current medicinal chemistry 20110101 |
| Rapid host defense against Aspergillus fumigatus involves alveolar macrophages with a predominance of alternatively activated phenotype. | PloS one 20110101 |
| Macrophage presence is essential for the regeneration of ascending afferent fibres following a conditioning sciatic nerve lesion in adult rats. | BMC neuroscience 20110101 |
| Influenza virus-like particles containing M2 induce broadly cross protective immunity. | PloS one 20110101 |
| The influence of bisphosphonates on human osteoblast migration and integrin aVb3/tenascin C gene expression in vitro. | Head & face medicine 20110101 |
| Intervening on the side effects of hormone-dependent cancer treatment: the role of strength training. | Journal of aging research 20110101 |
| Updated recommendations for the diagnosis and management of osteoporosis: a local perspective. | Annals of Saudi medicine 20110101 |
| The facial skeleton in patients with osteoporosis: a field for disease signs and treatment complications. | Journal of osteoporosis 20110101 |
| Report on the 2nd scientific meeting of the 'Verein zur Förderung des Wissenschaftlichen Nachwuchses in der Neurologie' (NEUROWIND e.V.) held in Motzen, Germany, Oct. 29'th - Oct. 31'st, 2010. | Experimental & translational stroke medicine 20110101 |
| Soluble vascular endothelial growth factor receptor-3 suppresses lymphangiogenesis and lymphatic metastasis in bladder cancer. | Molecular cancer 20110101 |
| Genome-wide expression profiling of five mouse models identifies similarities and differences with human psoriasis. | PloS one 20110101 |
| Further improvements of the P. falciparum humanized mouse model. | PloS one 20110101 |
| Recent applications of liposomes in ophthalmic drug delivery. | Journal of drug delivery 20110101 |
| Nanotechnology for the treatment of coronary in stent restenosis: a clinical perspective. | Vascular cell 20110101 |
| Supportive therapy in multiple myeloma. | Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 20110101 |
| Targeted liposomal drug delivery to monocytes and macrophages. | Journal of drug delivery 20110101 |
| Bordetella pertussis infection exacerbates influenza virus infection through pertussis toxin-mediated suppression of innate immunity. | PloS one 20110101 |
| Toxicokinetics of kava. | Advances in pharmacological sciences 20110101 |
| Fracture prevention in postmenopausal women. | BMJ clinical evidence 20110101 |
| Role of zoledronic acid in the prevention and treatment of osteoporosis. | Clinical interventions in aging 20110101 |
| Peripheral inflammation increases the damage in animal models of nigrostriatal dopaminergic neurodegeneration: possible implication in Parkinson's disease incidence. | Parkinson's disease 20110101 |
| Emerging strategies and therapies for treatment of Paget's disease of bone. | Drug design, development and therapy 20110101 |
| Classically and alternatively activated bone marrow derived macrophages differ in cytoskeletal functions and migration towards specific CNS cell types. | Journal of neuroinflammation 20110101 |
| Videoradiographic analysis of the range of motion in unilateral experimental knee joint arthritis in rats. | Arthritis research & therapy 20110101 |
| Comparing comorbidity measures for predicting mortality and hospitalization in three population-based cohorts. | BMC health services research 20110101 |
| Tiludronate treatment improves structural changes and symptoms of osteoarthritis in the canine anterior cruciate ligament model. | Arthritis research & therapy 20110101 |
| [Regression of an osteolytic lesion in a patient with multiple myeloma treated with clodronate after a successful therapy with bortezomib-based regimen]. | Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti 20110101 |
| Zoledronic acid inhibits vasculogenic mimicry in murine osteosarcoma cell line in vitro. | BMC musculoskeletal disorders 20110101 |
| Transition of tumor-associated macrophages from MHC class II(hi) to MHC class II(low) mediates tumor progression in mice. | BMC immunology 20110101 |
| Improvement of pain and regional osteoporotic changes in the foot and ankle by low-dose bisphosphonate therapy for complex regional pain syndrome type I: a case series. | Journal of medical case reports 20110101 |
| The herpetofauna of Timor-Leste: a first report. | ZooKeys 20110101 |
| Increased fracture rate in women with breast cancer: a review of the hidden risk. | BMC cancer 20110101 |
| The natural cytotoxicity receptor 1 contribution to early clearance of Streptococcus pneumoniae and to natural killer-macrophage cross talk. | PloS one 20110101 |
| Clodronate liposomes improve metabolic profile and reduce visceral adipose macrophage content in diet-induced obese mice. | PloS one 20110101 |
| Bone marrow stromal cell transplantation mitigates radiation-induced gastrointestinal syndrome in mice. | PloS one 20110101 |
| Prognostic and predictive value of clinical and biochemical factors in breast cancer patients with bone metastases receiving 'metronomic' zoledronic acid. | BMC cancer 20110101 |
| Cellular Interplay between Cardiomyocytes and Nonmyocytes in Cardiac Remodeling. | International journal of inflammation 20110101 |
| Activation of retinal microglia rather than microglial cell density correlates with retinal neovascularization in the mouse model of oxygen-induced retinopathy. | Journal of neuroinflammation 20110101 |
| The use of spinning-disk confocal microscopy for the intravital analysis of platelet dynamics in response to systemic and local inflammation. | PloS one 20110101 |
| Tumour macrophages as potential targets of bisphosphonates. | Journal of translational medicine 20110101 |
| Complex regional pain syndrome. | Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India 20110101 |
| Interleukin-1 as an injury signal mobilizes retinyl esters in hepatic stellate cells through down regulation of lecithin retinol acyltransferase. | PloS one 20110101 |
| The Chemical and Physical Properties of Poly(ε-caprolactone) Scaffolds Functionalised with Poly(vinyl phosphonic acid-co-acrylic acid). | Journal of tissue engineering 20110101 |
| Clinical utility of clodronate in the prevention and management of osteoporosis in patients intolerant of oral bisphosphonates. | Drug design, development and therapy 20110101 |
| Effects of ischemia on lung macrophages. | PloS one 20110101 |
| Bisphosphonates and breast cancer incidence and recurrence. | Breast disease 20110101 |
| Association between bisphosphonate use and implant survival after primary total arthroplasty of the knee or hip: population based retrospective cohort study. | BMJ (Clinical research ed.) 20110101 |
| Tumor cells and tumor-associated macrophages: secreted proteins as potential targets for therapy. | Clinical & developmental immunology 20110101 |
| From tumor immunosuppression to eradication: targeting homing and activity of immune effector cells to tumors. | Clinical & developmental immunology 20110101 |
| Antitumor immunity produced by the liver Kupffer cells, NK cells, NKT cells, and CD8 CD122 T cells. | Clinical & developmental immunology 20110101 |
| Contribution of classic and alternative effector pathways in peanut-induced anaphylactic responses. | PloS one 20110101 |
| Lansoprazole as a rescue agent in chemoresistant tumors: a phase I/II study in companion animals with spontaneously occurring tumors. | Journal of translational medicine 20110101 |
| Modulation of specific and allergy-related immune responses by helminths. | Journal of biomedicine & biotechnology 20110101 |
| A randomized controlled trial to compare the efficacy of bisphosphonates in the management of painful bone metastasis. | Indian journal of palliative care 20110101 |
| Osteoporosis and bisphosphonate-related osteonecrosis of the jaw bone. | ISRN rheumatology 20110101 |
| Inflammatory Animal Model for Parkinson's Disease: The Intranigral Injection of LPS Induced the Inflammatory Process along with the Selective Degeneration of Nigrostriatal Dopaminergic Neurons. | ISRN neurology 20110101 |
| New insights into the role of macrophages in adipose tissue inflammation and Fatty liver disease: modulation by endogenous omega-3 Fatty Acid-derived lipid mediators. | Frontiers in immunology 20110101 |
| Inflammatory cytokine release of astrocytes in vitro is reduced by all-trans retinoic acid. | Journal of neuroimmunology 20101215 |
| Zoledronic acid in myeloma: MRC Myeloma IX. | Lancet (London, England) 20101211 |
| First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma (MRC Myeloma IX): a randomised controlled trial. | Lancet (London, England) 20101202 |
| The utility and limitations of FRAX: A US perspective. | Current osteoporosis reports 20101201 |
| Fresh and cryopreserved, uncultured adipose tissue-derived stem and regenerative cells ameliorate ischemia-reperfusion-induced acute kidney injury. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20101201 |
| Management of castration-resistant prostate cancer: bisphosphonates and emerging therapies. | Expert review of anticancer therapy 20101201 |
| Pro-IL-1β accumulation in macrophages by alendronate and its prevention by clodronate. | Toxicology letters 20101130 |
| The role of Tregs and CD11c(+) macrophages/dendritic cells in ischemic preconditioning of the kidney. | Kidney international 20101101 |
| Up-regulation of heme oxygenase-1 by sevoflurane is not dependent on Kupffer cells and associates with ERK1/2 and AP-1 activation in the rat liver. | The international journal of biochemistry & cell biology 20101101 |
| Characterization of two F4/80-positive Kupffer cell subsets by their function and phenotype in mice. | Journal of hepatology 20101101 |
| Osteonecrosis of the jaw: effect of bisphosphonate type, local concentration, and acidic milieu on the pathomechanism. | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20101101 |
| Clodronate-containing liposomes attenuate lung injury in rats with severe acute pancreatitis. | Journal of Zhejiang University. Science. B 20101101 |
| Optimizing clinical benefits of bisphosphonates in cancer patients with bone metastases. | The oncologist 20101101 |
| Effects of clodronate on early alveolar bone remodeling and root resorption related to orthodontic forces: a histomorphometric analysis. | American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics 20101101 |
| Mechanisms of Cisplatin nephrotoxicity. | Toxins 20101101 |
| Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis. | Hepatology (Baltimore, Md.) 20101001 |
| Bisphosphonates as anticancer therapy for early breast cancer. | Clinical breast cancer 20101001 |
| Requirements for receptor engagement during infection by adenovirus complexed with blood coagulation factor X. | PLoS pathogens 20101001 |
| Antitumor effects and anticancer applications of bisphosphonates. | Seminars in oncology 20101001 |
| Effects of clodronate combined with hydroxyapatite on multi-directional differentiation of mesenchymal stromal cells. | Archives of medical science : AMS 20101001 |
| Design and synthesis of nonpeptidic, small molecule inhibitors for the Mycobacterium tuberculosis protein tyrosine phosphatase PtpB. | Organic & biomolecular chemistry 20100921 |
| In aged mice, outgrowth of intraocular melanoma depends on proangiogenic M2-type macrophages. | Journal of immunology (Baltimore, Md. : 1950) 20100915 |
| Distinct macrophage subpopulations regulate viral encephalitis but not viral clearance in the CNS. | Journal of neuroimmunology 20100914 |
| Use of bisphosphonates and raloxifene and risk of deep venous thromboembolism and pulmonary embolism. | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20100901 |
| Apoptotic cell-based therapies against transplant rejection: role of recipient's dendritic cells. | Apoptosis : an international journal on programmed cell death 20100901 |
| Kupffer cell depletion reduces hepatic inflammation and apoptosis but decreases survival in abdominal sepsis. | European journal of gastroenterology & hepatology 20100901 |
| Depletion of kidney CD11c+ F4/80+ cells impairs the recovery process in ischaemia/reperfusion-induced acute kidney injury. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20100901 |
| Conditions of retinal glial and inflammatory cell activation after irradiation in a GFP-chimeric mouse model. | Investigative ophthalmology & visual science 20100901 |
| Bone-marker levels in patients with prostate cancer: potential correlations with outcomes. | Current opinion in supportive and palliative care 20100901 |
| Technical advance: autofluorescence as a tool for myeloid cell analysis. | Journal of leukocyte biology 20100901 |
| Microglia promote colonization of brain tissue by breast cancer cells in a Wnt-dependent way. | Glia 20100901 |
| Assessment of individual fracture risk: FRAX and beyond. | Current osteoporosis reports 20100901 |
| Ulcerative colitis exacerbates lipopolysaccharide-induced damage to the nigral dopaminergic system: potential risk factor in Parkinson`s disease. | Journal of neurochemistry 20100901 |
| [Bisphosphonates in adjuvant therapy of breast cancer]. | Medizinische Klinik (Munich, Germany : 1983) 20100901 |
| Gene therapy with helper-dependent adenoviral vectors: current advances and future perspectives. | Viruses 20100901 |
| Improving adenovirus based gene transfer: strategies to accomplish immune evasion. | Viruses 20100901 |
| Zoledronic acid impairs myeloid differentiation to tumour-associated macrophages in mesothelioma. | British journal of cancer 20100824 |
| Transient neutropenia increases macrophage accumulation and cell proliferation but does not improve repair following intratendinous rupture of Achilles tendon. | Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20100801 |
| Differential role of tumor necrosis factor (TNF)-alpha receptors in the development of choroidal neovascularization. | Investigative ophthalmology & visual science 20100801 |
| Should bisphosphonates be utilized in the adjuvant setting for breast cancer? | Breast cancer research and treatment 20100801 |
| Effects of continuous combined hormone replacement therapy and clodronate on bone mineral density in osteoporotic postmenopausal women: a 5-year follow-up. | Maturitas 20100801 |
| Ischemia reperfusion induces IFN regulatory factor 4 in renal dendritic cells, which suppresses postischemic inflammation and prevents acute renal failure. | Journal of immunology (Baltimore, Md. : 1950) 20100801 |
| Fluid pressure and flow as a cause of bone resorption. | Acta orthopaedica 20100801 |
| Involvement of natural killer T cells in halothane-induced liver injury in mice. | Biochemical pharmacology 20100715 |
| Selective removal of macrophages in atherosclerotic plaques as a pharmacological approach for plaque stabilization: benefits versus potential complications. | Current vascular pharmacology 20100701 |
| Nicotinic acid adenine dinucleotide phosphate-mediated calcium signalling in effector T cells regulates autoimmunity of the central nervous system. | Brain : a journal of neurology 20100701 |
| Depletion of tumor-associated macrophages enhances the effect of sorafenib in metastatic liver cancer models by antimetastatic and antiangiogenic effects. | Clinical cancer research : an official journal of the American Association for Cancer Research 20100701 |
| Macrophage depletion attenuates chronic cyclosporine A nephrotoxicity. | Transplantation 20100615 |
| Alkaline and alkaline earth metal complexes of dianhydride derivatives of clodronate and their hydrolysis products. | Dalton transactions (Cambridge, England : 2003) 20100614 |
| [The role of bisphosphonates of adjuvant therapy in breast cancer]. | Medicina clinica 20100612 |
| Longitudinal change in clinical fracture incidence after initiation of bisphosphonates. | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20100601 |
| Adenosine A1 receptors and microglial cells mediate CX3CL1-induced protection of hippocampal neurons against Glu-induced death. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20100601 |
| Decreased periprosthetic bone loss in patients treated with clodronate: a 1-year randomized controlled study. | Calcified tissue international 20100601 |
| Osteonecrosis of the jaw induced by clodronate, an alkylbiphosphonate: case report and literature review. | European journal of clinical pharmacology 20100601 |
| Effective dosage and administration schedule of oral alendronate for non-nociceptive symptoms in rats with chronic constriction injury. | Journal of Korean medical science 20100601 |
| The neurological safety of epidural pamidronate in rats. | The Korean journal of pain 20100601 |
| The evolving role of bone-conserving therapy in patients with breast cancer. | Seminars in oncology 20100601 |
| Therapeutic options in the management of myeloma bone disease. | Seminars in oncology 20100601 |
| Differential cell sensitivity between OTA and LPS upon releasing TNF-α. | Toxins 20100601 |
| Murine Kupffer cells are protective in total hepatic ischemia/reperfusion injury with bowel congestion through IL-10. | Journal of immunology (Baltimore, Md. : 1950) 20100515 |
| Role of brain macrophages on IL-1beta and fatigue following eccentric exercise-induced muscle damage. | Brain, behavior, and immunity 20100501 |
| Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes. | Nature immunology 20100501 |
| Imaging of atherosclerosis in apoliprotein e knockout mice: targeting of a folate-conjugated radiopharmaceutical to activated macrophages. | Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20100501 |
| A case of Paget's disease in hemodialysis. | Clinical nephrology 20100501 |
| Prolonged antigen presentation is required for optimal CD8+ T cell responses against malaria liver stage parasites. | PLoS pathogens 20100501 |
| 'Twice-a-month' clodronate 200 mg IM: a new dosing regimen and improved therapy adherence in the treatment of postmenopausal osteoporosis. | Advances in therapy 20100501 |
| Kupffer cells participate in 2-butoxyethanol-induced liver hemangiosarcomas. | Toxicology 20100411 |
| [Teeth and irradiation: dental care and treatment of osteoradionecrosis after irradiation in head and neck cancer]. | Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique 20100401 |
| 9-Deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid are slow-binding picomolar inhibitors of trimeric purine nucleoside phosphorylase. | The FEBS journal 20100401 |
| IL-10 mediates rosiglitazone-induced kidney protection in cisplatin nephrotoxicity. | Journal of Korean medical science 20100401 |
| MRI shows clodronate-liposomes attenuating liver injury in rats with severe acute pancreatitis. | Hepatobiliary & pancreatic diseases international : HBPD INT 20100401 |
| Feasibility of administering zoledronic acid in palliative patients being cared for in the community: results of a pilot study. | Current oncology (Toronto, Ont.) 20100401 |
| Bisphosphonates in adjuvant treatment of early breast cancer. | Critical reviews in oncology/hematology 20100401 |
| Routine adjuvant use of bisphosphonates in breast cancer arguments in favour and against. | Critical reviews in oncology/hematology 20100401 |
| Inadequate clearance of translocated bacterial products in HIV-infected humanized mice. | PLoS pathogens 20100401 |
| The effects of adding zoledronic acid to neoadjuvant chemotherapy on tumour response: exploratory evidence for direct anti-tumour activity in breast cancer. | British journal of cancer 20100330 |
| Therapeutic antibodies to human L1CAM: functional characterization and application in a mouse model for ovarian carcinoma. | Cancer research 20100315 |
| Evaluation of liposomal clodronate for treatment of malignant histiocytosis in dogs. | Cancer immunology, immunotherapy : CII 20100301 |
| In vivo depletion of CD4+FOXP3+ Treg cells by the PC61 anti-CD25 monoclonal antibody is mediated by FcgammaRIII+ phagocytes. | European journal of immunology 20100301 |
| Mononuclear phagocyte system depletion blocks interstitial tonicity-responsive enhancer binding protein/vascular endothelial growth factor C expression and induces salt-sensitive hypertension in rats. | Hypertension (Dallas, Tex. : 1979) 20100301 |
| Brain perivascular macrophages and the sympathetic response to inflammation in rats after myocardial infarction. | Hypertension (Dallas, Tex. : 1979) 20100301 |
| The effect of zoledronate during bone healing. | Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology 20100301 |
| Blockade of tumor necrosis factor alpha signaling in tumor-associated macrophages as a radiosensitizing strategy. | Cancer research 20100215 |
| Influence of bisphosphonates on endothelial cells, fibroblasts, and osteogenic cells. | Clinical oral investigations 20100201 |
| Gastric and esophagus events before and during treatment of osteoporosis. | Calcified tissue international 20100201 |
| Effect of oral clodronate on bone mass, bone turnover and subsequent metastases in women with primary breast cancer. | European journal of cancer (Oxford, England : 1990) 20100201 |
| Kupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity. | Hepatology (Baltimore, Md.) 20100201 |
| Rapid analysis of alkylphosphonate drugs by capillary zone electrophoresis using indirect ultraviolet detection. | Journal of separation science 20100201 |
| Clodronate liposomes: all sites of injection are not equal. | Hepatology (Baltimore, Md.) 20100201 |
| Lack of association between oestrogen receptor polymorphisms and change in bone mineral density with tamoxifen therapy. | British journal of cancer 20100119 |
| Bisphosphonates suppress insulin-like growth factor 1-induced angiogenesis via the HIF-1alpha/VEGF signaling pathways in human breast cancer cells. | International journal of cancer 20100101 |
| Biomimetic Ca-P coatings incorporating bisphosphonates produced on starch-based degradable biomaterials. | Journal of biomedical materials research. Part B, Applied biomaterials 20100101 |
| Neutrophil recruitment in endotoxin-induced murine mastitis is strictly dependent on mammary alveolar macrophages. | Veterinary research 20100101 |
| Kupffer cell activation is a causal factor for hepatic insulin resistance. | American journal of physiology. Gastrointestinal and liver physiology 20100101 |
| Phosphatase inhibitors with anti-angiogenic effect in vitro. | APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20100101 |
| Liposomes for specific depletion of macrophages from organs and tissues. | Methods in molecular biology (Clifton, N.J.) 20100101 |
| Retrospective French nationwide survey of childhood aggressive vascular anomalies of bone, 1988-2009. | Orphanet journal of rare diseases 20100101 |
| Metastatic breast carcinoma of the coracoid process: two case reports. | Journal of orthopaedic surgery and research 20100101 |
| Evidence based guidelines for complex regional pain syndrome type 1. | BMC neurology 20100101 |
| A crucial role for tumor necrosis factor receptor 1 in synovial lining cells and the reticuloendothelial system in mediating experimental arthritis. | Arthritis research & therapy 20100101 |
| In vivo bioluminescence imaging and histopathopathologic analysis reveal distinct roles for resident and recruited immune effector cells in defense against invasive aspergillosis. | BMC microbiology 20100101 |
| Role of inflammation in túbulo-interstitial damage associated to obstructive nephropathy. | Journal of inflammation (London, England) 20100101 |
| Essential role of neutrophils but not mammary alveolar macrophages in a murine model of acute Escherichia coli mastitis. | Veterinary research 20100101 |
| Treatment with imiquimod enhances antitumor immunity induced by therapeutic HPV DNA vaccination. | Journal of biomedical science 20100101 |
| Robust uptake of magnetic nanoparticles (MNPs) by central nervous system (CNS) microglia: implications for particle uptake in mixed neural cell populations. | International journal of molecular sciences 20100101 |
| Dihydrotachysterol intoxication treated with pamidronate: a case report. | Cases journal 20100101 |
| Toll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis. | BMC gastroenterology 20100101 |
| Interleukin-10 production by tumor infiltrating macrophages plays a role in Human Papillomavirus 16 tumor growth. | BMC immunology 20100101 |
| Analysis of innate defences against Plasmodium falciparum in immunodeficient mice. | Malaria journal 20100101 |
| The impact of bisphosphonates on the osteoblast proliferation and Collagen gene expression in vitro. | Head & face medicine 20100101 |
| The TLR4/TRIF-Mediated Activation of NLRP3 Inflammasome Underlies Endotoxin-Induced Liver Injury in Mice. | Gastroenterology research and practice 20100101 |
| An open cohort study of bone metastasis incidence following surgery in breast cancer patients. | BMC cancer 20100101 |
| Apoptosis and autoimmunity induced by clodronate in systemic lupus erythematosus mononuclear circulating cells. | International journal of immunopathology and pharmacology 20100101 |
| Conjunctival macrophages act as antigen-presenting cells in the conjunctiva during the development of experimental allergic conjunctivitis. | Molecular vision 20100101 |
| Long-term treatment with bisphosphonates and their safety in postmenopausal osteoporosis. | Therapeutics and clinical risk management 20100101 |
| Post-operative breast cancer patients diagnosed with skeletal metastasis without bone pain had fewer skeletal-related events and deaths than those with bone pain. | BMC cancer 20100101 |
| Toll-like receptor signaling and liver fibrosis. | Gastroenterology research and practice 20100101 |
| Bisphosphonates: molecular mechanisms of action and effects on bone cells, monocytes and macrophages. | Current pharmaceutical design 20100101 |
| Bisphosphonate treatment of aggressive primary, recurrent and metastatic Giant Cell Tumour of Bone. | BMC cancer 20100101 |
| Toll-like receptors in the pathogenesis of alcoholic liver disease. | Gastroenterology research and practice 20100101 |
| Development of a macromolecular prodrug for the treatment of inflammatory arthritis: mechanisms involved in arthrotropism and sustained therapeutic efficacy. | Arthritis research & therapy 20100101 |
| TLRs in Hepatic Cellular Crosstalk. | Gastroenterology research and practice 20100101 |
| Bone marrow derived mesenchymal stem cells incorporate into the prostate during regrowth. | PloS one 20100101 |
| Evaluation of an aminobisphosphonate (alendronate) in the management of periodontal osseous defects. | Journal of Indian Society of Periodontology 20100101 |
| NK cell depletion delays corneal allograft rejection in baby rats. | Molecular vision 20100101 |
| Breast cancer in young women. | Breast cancer research : BCR 20100101 |
| Immunomodulatory dietary polysaccharides: a systematic review of the literature. | Nutrition journal 20100101 |
| Value of entheseal ultrasonography and serum cartilage oligomeric matrix protein in the preclinical diagnosis of psoriatic arthritis. | Clinical medicine insights. Arthritis and musculoskeletal disorders 20100101 |
| Prevention of bone metastases and management of bone health in early breast cancer. | Breast cancer research : BCR 20100101 |
| Anti-tumour activity of bisphosphonates in preclinical models of breast cancer. | Breast cancer research : BCR 20100101 |
| Effects of an alpha-4 integrin inhibitor on restenosis in a new porcine model combining endothelial denudation and stent placement. | PloS one 20100101 |
| Critical role of macrophages and their activation via MyD88-NFκB signaling in lung innate immunity to Mycoplasma pneumoniae. | PloS one 20100101 |
| Improving management of patients with advanced cancer. | Patient preference and adherence 20100101 |
| Osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphanates. | Prilozi 20100101 |
| Role of toll-like receptors and their downstream molecules in the development of nonalcoholic Fatty liver disease. | Gastroenterology research and practice 20100101 |
| Antigen presentation to B cells. | F1000 biology reports 20100101 |
| Wound healing in mice with high-fat diet- or ob gene-induced diabetes-obesity syndromes: a comparative study. | Experimental diabetes research 20100101 |
| Management of glucocorticoid-induced osteoporosis: prevalence, and emerging treatment options. | Drug, healthcare and patient safety 20100101 |
| Safety and tolerability of zoledronic acid and other bisphosphonates in osteoporosis management. | Drug, healthcare and patient safety 20100101 |
| Rejection of intradermally injected syngeneic tumor cells from mice by specific elimination of tumor-associated macrophages with liposome-encapsulated dichloromethylene diphosphonate, followed by induction of CD11b(+)/CCR3(-)/Gr-1(-) cells cytotoxic against the tumor cells. | Cancer immunology, immunotherapy : CII 20091201 |
| Can fall risk be incorporated into fracture risk assessment algorithms: a pilot study of responsiveness to clodronate. | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20091201 |
| Further analysis of the survival benefit of clodronate. | Cancer biology & therapy 20091201 |
| Central neuroinvasion and demyelination by inflammatory macrophages after peripheral virus infection is controlled by SHP-1. | Viral immunology 20091201 |
| Macrophage depletion suppresses sympathetic hyperinnervation following myocardial infarction. | Basic research in cardiology 20091101 |
| Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling. | Biochimica et biophysica acta 20091101 |
| Contribution of macrophages to angiogenesis induced by vascular endothelial growth factor receptor-3-specific ligands. | The American journal of pathology 20091101 |
| Effects of liposome clodronate on renal leukocyte populations and renal fibrosis in murine obstructive nephropathy. | Journal of pharmacological sciences 20091101 |
| Bisphosphonates in the prevention of disease recurrence: current results and ongoing trials. | Current cancer drug targets 20091101 |
| Fate of endothelialized modular constructs implanted in an omental pouch in nude rats. | Tissue engineering. Part A 20091001 |
| How T-cell-dependent and -independent challenges access the brain: vascular and neural responses to bacterial lipopolysaccharide and staphylococcal enterotoxin B. | Brain, behavior, and immunity 20091001 |
| Depletion of macrophages in mice results in higher dengue virus titers and highlights the role of macrophages for virus control. | European journal of immunology 20091001 |
| Role of CD11b+ macrophages in intraperitoneal lipopolysaccharide-induced aberrant lymphangiogenesis and lymphatic function in the diaphragm. | The American journal of pathology 20091001 |
| Evasion by stealth: inefficient immune activation underlies poor T cell response and severe disease in SARS-CoV-infected mice. | PLoS pathogens 20091001 |
| The alpha,alpha-difluorinated phosphonate L-pSer-analogue: an accessible chemical tool for studying kinase-dependent signal transduction. | Chemistry & biology 20090925 |
| Resident dendritic cells prevent postischemic acute renal failure by help of single Ig IL-1 receptor-related protein. | Journal of immunology (Baltimore, Md. : 1950) 20090915 |
| Adjuvant therapy with oral sodium clodronate in locally advanced and metastatic prostate cancer: long-term overall survival results from the MRC PR04 and PR05 randomised controlled trials. | The Lancet. Oncology 20090909 |
| New results from the use of bisphosphonates in cancer patients. | Current opinion in supportive and palliative care 20090901 |
| Primary biliary cirrhosis. | Seminars in immunopathology 20090901 |
| SIGNR1-negative red pulp macrophages protect against acute streptococcal sepsis after Leishmania donovani-induced loss of marginal zone macrophages. | The American journal of pathology 20090901 |
| Interleukin-1 deficiency in combination with macrophage depletion increases susceptibility to Pseudomonas aeruginosa bacteremia. | Microbiology and immunology 20090901 |
| A novel animal model of Borrelia recurrentis louse-borne relapsing fever borreliosis using immunodeficient mice. | PLoS neglected tropical diseases 20090901 |
| Elevated endogenous surfactant reduces inflammation in an acute lung injury model. | Experimental lung research 20090901 |
| c-Jun terminal kinase-2 gene deleted mice overexpress hemeoxygenase-1 and are protected from hepatic ischemia reperfusion injury. | Transplantation 20090815 |
| Switching breast cancer patients with progressive bone metastases to third-generation bisphosphonates: measuring impact using the Functional Assessment of Cancer Therapy-Bone Pain. | Journal of pain and symptom management 20090801 |
| Chorionic gonadotropin alleviates thioglycollate-induced peritonitis by affecting macrophage function. | Journal of leukocyte biology 20090801 |
| Clodronate-induced cell apoptosis in human thyroid carcinoma is mediated via the P2 receptor signaling pathway. | The Journal of pharmacology and experimental therapeutics 20090801 |
| TLR9-dependent systemic interferon-beta production by intravenous injection of plasmid DNA/cationic liposome complex in mice. | The journal of gene medicine 20090801 |
| The use of bisphosphonates in multiple myeloma: recommendations of an expert panel on behalf of the European Myeloma Network. | Annals of oncology : official journal of the European Society for Medical Oncology 20090801 |
| Osteonecrosis of the jaw and use of bisphosphonates in adjuvant breast cancer treatment: a meta-analysis. | Breast cancer research and treatment 20090801 |
| Macrophages are alternatively activated in patients with endometriosis and required for growth and vascularization of lesions in a mouse model of disease. | The American journal of pathology 20090801 |
| Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1beta release through pyrophosphates. | The EMBO journal 20090722 |
| Fluorescent tumour imaging of type I IGF receptor in vivo: comparison of antibody-conjugated quantum dots and small-molecule fluorophore. | British journal of cancer 20090707 |
| Intra-articular clodronate for the treatment of knee osteoarthritis: dose ranging study vs hyaluronic acid. | Rheumatology (Oxford, England) 20090701 |
| CCR2 promotes hepatic fibrosis in mice. | Hepatology (Baltimore, Md.) 20090701 |
| Adjuvant bisphosphonates in breast cancer: are we witnessing the emergence of a new therapeutic strategy? | European journal of cancer (Oxford, England : 1990) 20090701 |
| Cellular effectors mediating Th17-dependent clearance of pneumococcal colonization in mice. | The Journal of clinical investigation 20090701 |
| Role of macrophages in the development of pancreatic islet injury in spontaneously diabetic torii rats. | Experimental animals 20090701 |
| Zoledronic acid induces formation of a pro-apoptotic ATP analogue and isopentenyl pyrophosphate in osteoclasts in vivo and in MCF-7 cells in vitro. | British journal of pharmacology 20090601 |
| Opposite roles of CCR2 and CX3CR1 macrophages in alkali-induced corneal neovascularization. | Cornea 20090601 |
| Identification of a subpopulation of macrophages in mammary tumor-bearing mice that are neither M1 nor M2 and are less differentiated. | Cancer research 20090601 |
| Maintaining bone density in patients undergoing treatment for breast cancer: is there an adjuvant benefit? | Clinical breast cancer 20090601 |
| Role of lung-marginated monocytes in an in vivo mouse model of ventilator-induced lung injury. | American journal of respiratory and critical care medicine 20090515 |
| Ten-year fracture probability identifies women who will benefit from clodronate therapy--additional results from a double-blind, placebo-controlled randomised study. | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20090501 |
| Potential role of macrophages in experimental keratomycosis. | Investigative ophthalmology & visual science 20090501 |
| Macrophage depletion delays progression of neuropathic pain in diabetic animals. | Naunyn-Schmiedeberg's archives of pharmacology 20090501 |
| Osteonecrosis of the jaw complicating bisphosphonate treatment for bone disease in multiple myeloma: an overview with recommendations for prevention and treatment. | Internal medicine journal 20090501 |
| Effect of depletion of monocytes/macrophages on early aortic valve lesion in experimental hyperlipidemia. | Cell and tissue research 20090501 |
| Necrotic actions of nitrogen-containing bisphosphonates and their inhibition by clodronate, a non-nitrogen-containing bisphosphonate in mice: potential for utilization of clodronate as a combination drug with a nitrogen-containing bisphosphonate. | Basic & clinical pharmacology & toxicology 20090501 |
| Efficacy of clodronate, pamidronate, and zoledronate in reducing morbidity and mortality in cancer patients with bone metastasis: a meta-analysis of randomized clinical trials. | Clinical therapeutics 20090501 |
| Weekly clodronate treatment prevents bone loss and vertebral fractures in women with subclinical Cushing's syndrome. | Journal of endocrinological investigation 20090501 |
| PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis. | Proceedings of the National Academy of Sciences of the United States of America 20090414 |
| Effect of allyl alcohol on hepatic transporter expression: zonal patterns of expression and role of Kupffer cell function. | Toxicology and applied pharmacology 20090401 |
| Macrophage depletion in hypertensive rats accelerates development of cardiomyopathy. | Journal of cardiovascular pharmacology and therapeutics 20090301 |
| Chitin, chitinases and chitinase-like proteins in allergic inflammation and tissue remodeling. | Yonsei medical journal 20090227 |
| Celecoxib does not appear to affect prosthesis fixation in total knee replacement: A randomized study using radiostereometry in 50 patients. | Acta orthopaedica 20090226 |
| Bisphosphonates and implants: an overview. | Acta orthopaedica 20090226 |
| Once-weekly oral medication with alendronate does not prevent migration of knee prostheses: A double-blind randomized RSA study. | Acta orthopaedica 20090226 |
| Alendronate augments interleukin-1beta release from macrophages infected with periodontal pathogenic bacteria through activation of caspase-1. | Toxicology and applied pharmacology 20090215 |
| Effect of macrophage depletion on viral DNA rebound following antiretroviral therapy in a murine model of AIDS (MAIDS). | Antiviral research 20090201 |
| Depletion of phagocytes in the reticuloendothelial system causes increased inflammation and mortality in rabbits with Pseudomonas aeruginosa pneumonia. | American journal of physiology. Lung cellular and molecular physiology 20090201 |
| Treating low- and medium-potency bisphosphonate-related osteonecrosis of the jaws with a protocol for the treatment of chronic suppurative osteomyelitis: report of 7 cases. | Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20090201 |
| Extratumoral macrophages promote tumor and vascular growth in an orthotopic rat prostate tumor model. | Neoplasia (New York, N.Y.) 20090201 |
| Peritoneal macrophages are important for the early containment of Enterococcus faecium peritonitis in mice. | Innate immunity 20090201 |
| Clinical application of bisphosphonates in implant dentistry: histomorphometric evaluation. | The International journal of periodontics & restorative dentistry 20090201 |
| Macrophages and Fc-receptor interactions contribute to the antitumour activities of the anti-CD40 antibody SGN-40. | British journal of cancer 20090113 |
| Decreased occurrence of osteonecrosis of the jaw after implementation of dental preventive measures in solid tumour patients with bone metastases treated with bisphosphonates. The experience of the National Cancer Institute of Milan. | Annals of oncology : official journal of the European Society for Medical Oncology 20090101 |
| Value of information and value of implementation: application of an analytic framework to inform resource allocation decisions in metastatic hormone-refractory prostate cancer. | Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20090101 |
| Selective depletion of alveolar macrophages in polymicrobial sepsis increases lung injury, bacterial load and mortality but does not affect cytokine release. | Respiration; international review of thoracic diseases 20090101 |
| Tissue-resident macrophages protect the liver from ischemia reperfusion injury via a heme oxygenase-1-dependent mechanism. | Molecular therapy : the journal of the American Society of Gene Therapy 20090101 |
| Inhibition of osteoblast function in vitro by aminobisphosphonates. | Journal of cellular biochemistry 20090101 |
| Regulation of liver hepcidin expression by alcohol in vivo does not involve Kupffer cell activation or TNF-alpha signaling. | American journal of physiology. Gastrointestinal and liver physiology 20090101 |
| Resident macrophages initiating and driving inflammation in a monosodium urate monohydrate crystal-induced murine peritoneal model of acute gout. | Arthritis and rheumatism 20090101 |
| Radiological changes following second-line zoledronic acid treatment in breast cancer patients with bone metastases. | Clinical & experimental metastasis 20090101 |
| Expression of toll-like receptor 4 in uvea-resident tissue macrophages during endotoxin-induced uveitis. | Molecular vision 20090101 |
| WHO fracture risk calculator (FRAX) in the assessment of obese patients with osteoporosis. | Endokrynologia Polska 20090101 |
| RANKL increases the level of Mcl-1 in osteoclasts and reduces bisphosphonate-induced osteoclast apoptosis in vitro. | Arthritis research & therapy 20090101 |
| Clodronic acid formulations available in Europe and their use in osteoporosis: a review. | Clinical drug investigation 20090101 |
| Biphosphonates-related osteonecrosis of the jaw: Clinical and physiopathological considerations. | Therapeutics and clinical risk management 20090101 |
| Potential antitumor effects of nitrogen-containing bisphosphonate in hormone receptor negative breast cancer patients with bone metastases. | BMC cancer 20090101 |
| Once-yearly zoledronic acid in hip fracture prevention. | Clinical interventions in aging 20090101 |
| Chemokine receptor CXCR4 expression in hepatocellular carcinoma patients increases the risk of bone metastases and poor survival. | BMC cancer 20090101 |
| A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth. | PloS one 20090101 |
| Resident macrophages influence stem cell activity in the mammary gland. | Breast cancer research : BCR 20090101 |
| Management strategies for pulmonary sarcoidosis. | Therapeutics and clinical risk management 20090101 |
| Interleukin-10 overexpression promotes Fas-ligand-dependent chronic macrophage-mediated demyelinating polyneuropathy. | PloS one 20090101 |
| Bisphosphonates and atrial fibrillation: Bayesian meta-analyses of randomized controlled trials and observational studies. | BMC musculoskeletal disorders 20090101 |
| Clodronate combined with a surfactant (Tween 20) does not improve osseointegration: a rabbit immunohistomorphometric study. | International journal of immunopathology and pharmacology 20090101 |
| Radiological and CT findings in a extensive upper-limb involvement of Gorham's Disease: a case report. | Cases journal 20090101 |
| Whole body bone scintigraphy in tenofovir-related osteomalacia: a case report. | Journal of medical case reports 20090101 |
| Progress in osteoporosis and fracture prevention: focus on postmenopausal women. | Arthritis research & therapy 20090101 |
| Lasofoxifene for the prevention and treatment of postmenopausal osteoporosis. | Therapeutics and clinical risk management 20090101 |
| Bisphosphonates in oncology: evidence for the prevention of skeletal events in patients with bone metastases. | Drug design, development and therapy 20090101 |
| Predicting risk of osteoporotic fracture in men and women in England and Wales: prospective derivation and validation of QFractureScores. | BMJ (Clinical research ed.) 20090101 |
| SAPHO Syndrome Diagnosis and Treatment: Report of Five Cases and Review of the Literature. | The open orthopaedics journal 20090101 |
| Tartrate-resistant acid phosphatase (TRAP) as a serum marker for bone resorption in breast cancer patients with bone metastases. | Clinical and experimental obstetrics & gynecology 20090101 |
| Mediators of inflammation in acute kidney injury. | Mediators of inflammation 20090101 |
| Efficacy of intramuscular clodronate in Complex Regional Pain Syndrome type I: description of a case located in the astragalus in a patient with psoriatic arthritis. | Acta bio-medica : Atenei Parmensis 20090101 |
| The evolving role of zoledronic acid in early breast cancer. | OncoTargets and therapy 20090101 |
| Immune-to-brain signalling: the role of cerebral CD163-positive macrophages. | Neuroscience letters 20081219 |
| Significant clinical improvement in radiation-induced lumbosacral polyradiculopathy by a treatment combining pentoxifylline, tocopherol, and clodronate (Pentoclo). | Journal of the neurological sciences 20081215 |
| Macrophage impairment underlies airway occlusion in primary respiratory syncytial virus bronchiolitis. | The Journal of infectious diseases 20081215 |
| The role of macrophage in the pathogenesis of chronic cyclosporine-induced nephropathy. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20081201 |
| Adjuvant oral clodronate improves the overall survival of primary breast cancer patients with micrometastases to the bone marrow: a long-term follow-up. | Annals of oncology : official journal of the European Society for Medical Oncology 20081201 |
| An alpha5beta1 integrin inhibitor attenuates glioma growth. | Molecular and cellular neurosciences 20081201 |
| Assessment of metalloproteinase inhibitors clodronate and doxycycline in the neutralization of hemorrhage and coagulopathy induced by Bothrops asper snake venom. | Toxicon : official journal of the International Society on Toxinology 20081201 |
| Vertebral fracture assessment using standard bone densitometry equipment predicts incident fractures in women. | Nature clinical practice. Endocrinology & metabolism 20081201 |
| Vitamin D receptor gene polymorphisms predict acquired resistance to clodronate treatment in patients with Paget's disease of bone. | Calcified tissue international 20081201 |
| Influence of ligand valency on the targeting of immature human dendritic cells by mannosylated liposomes. | Bioconjugate chemistry 20081201 |
| MyD88 is required for protection from lethal infection with a mouse-adapted SARS-CoV. | PLoS pathogens 20081201 |
| Orbital metastasis as primary clinical manifestation of thyroid carcinoma--case report and literature review. | Arquivos brasileiros de endocrinologia e metabologia 20081201 |
| Aromatase inhibitors, efficacy and metabolic risk in the treatment of postmenopausal women with early breast cancer. | Clinical interventions in aging 20081201 |
| Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP. | Blood 20081115 |
| Determination of bisphosphonate active pharmaceutical ingredients in pharmaceuticals and biological material: a review of analytical methods. | Journal of pharmaceutical and biomedical analysis 20081104 |
| Interleukin-18 binding protein transgenic mice are protected against ischemic acute kidney injury. | American journal of physiology. Renal physiology 20081101 |
| Effect of short-term macrophage depletion in the development of posterior capsule opacification in rodents. | The British journal of ophthalmology 20081101 |
| Dendritic cells facilitate accumulation of IL-17 T cells in the kidney following acute renal obstruction. | Kidney international 20081101 |
| [Bisphosphonates for osseus invasion caused by bronchial carcinoma]. | Deutsche medizinische Wochenschrift (1946) 20081101 |
| Postmenopausal osteoporosis. The role of intravenous bisphosphonates. | Advance for nurse practitioners 20081101 |
| Macrophage-independent T cell infiltration to the site of injury-induced brain inflammation. | Journal of neuroimmunology 20081015 |
| Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. | Journal of medicinal chemistry 20081009 |
| Platelet dynamics in the early phase of postischemic liver in vivo. | The Journal of surgical research 20081001 |
| Vertebral fracture assessment (VFA) with a densitometer predicts future fractures in elderly women unselected for osteoporosis. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20081001 |
| Liver Kupffer cells control the magnitude of the inflammatory response in the injured brain and spinal cord. | Neuropharmacology 20081001 |
| Bisphosphonates activate the 5-fluorouracil/uracil phosphoribosyltransferase activity present in Saccharomyces cerevisiae cell extracts: implications for tumor treatments. | Biochemical pharmacology 20081001 |
| Bacterial entry to the splenic white pulp initiates antigen presentation to CD8+ T cells. | Immunity 20080919 |
| Another barrier to regeneration in the CNS: activated macrophages induce extensive retraction of dystrophic axons through direct physical interactions. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20080917 |
| Ten-year follow-up of 3 years of oral adjuvant clodronate therapy shows significant prevention of osteoporosis in early-stage breast cancer. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080910 |
| Effects of inflammatory response on in vivo transgene expression by plasmid DNA in mice. | Journal of pharmaceutical sciences 20080801 |
| Investigation into the role of tumor-associated macrophages in the antitumor activity of Doxil. | Pharmaceutical research 20080801 |
| A role of phosphatidylserine externalization in clearance of erythrocytes exposed to stress but not in eliminating aging populations of erythrocyte in mice. | Experimental gerontology 20080801 |
| Hepatic Mrp4 induction following acetaminophen exposure is dependent on Kupffer cell function. | American journal of physiology. Gastrointestinal and liver physiology 20080801 |
| Depletion of resident alveolar macrophages does not prevent Fas-mediated lung injury in mice. | American journal of physiology. Lung cellular and molecular physiology 20080801 |
| Liposomes for targeting of antigens and drugs: immunoadjuvant activity and liposome-mediated depletion of macrophages. | Journal of drug targeting 20080801 |
| Lymphatic targeting of immuno-PEG-liposomes: evaluation of antibody-coupling procedures on lymph node macrophage uptake. | Journal of drug targeting 20080801 |
| Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophages. | Cancer science 20080801 |
| Tumoricidal activity of high-dose tumor necrosis factor-alpha is mediated by macrophage-derived nitric oxide burst and permanent blood flow shutdown. | International journal of cancer 20080715 |
| A re-examination of the difluoromethylenesulfonic acid group as a phosphotyrosine mimic for PTP1B inhibition. | Bioorganic & medicinal chemistry 20080715 |
| Differential effects of GdCl3- or MDP treatment on rat liver microcirculation and gene expression in the hepatic non-parenchymal cell fraction in LPS shock. | Microcirculation (New York, N.Y. : 1994) 20080701 |
| Macrophage depletion diminishes implant-wear-induced inflammatory osteolysis in a mouse model. | Journal of biomedical materials research. Part A 20080615 |
| Risks and benefits of bisphosphonates. | British journal of cancer 20080603 |
| Preclinical evidence for nitrogen-containing bisphosphonate inhibition of farnesyl diphosphate (FPP) synthase in the kidney: implications for renal safety. | Toxicology in vitro : an international journal published in association with BIBRA 20080601 |
| Functional and phenotypic characteristics of testicular macrophages in experimental autoimmune orchitis. | The Journal of pathology 20080601 |
| Farnesyl diphosphate synthase is involved in the resistance to zoledronic acid of osteosarcoma cells. | Journal of cellular and molecular medicine 20080601 |
| Newly developed multiple myeloma in a patient with primary T-cell lymphoma of bone. | Journal of Korean medical science 20080601 |
| Hepatitis C virus helicase/NTPase: an efficient expression system and new inhibitors. | Biochemistry. Biokhimiia 20080601 |
| The investigation of macrophage infiltration in the early phase of ischemic acute renal failure in mice. | The Korean journal of internal medicine 20080601 |
| Bisphosphonates in the management of postmenopausal osteoporosis--optimizing efficacy in clinical practice. | Clinical interventions in aging 20080601 |
| Synthesis of bisphosphonate derivatives of ATP by T4 DNA ligase, ubiquitin activating enzyme (E1) and other ligases. | Biochemical pharmacology 20080515 |
| Effects of risedronate on fracture risk in postmenopausal women with osteopenia. | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20080501 |
| Migration of Apicomplexa across biological barriers: the Toxoplasma and Plasmodium rides. | Traffic (Copenhagen, Denmark) 20080501 |
| Macrophage colony-stimulating factor is indispensable for repopulation and differentiation of Kupffer cells but not for splenic red pulp macrophages in osteopetrotic (op/op) mice after macrophage depletion. | Cell and tissue research 20080501 |
| Benefits of oat beta-glucan on respiratory infection following exercise stress: role of lung macrophages. | American journal of physiology. Regulatory, integrative and comparative physiology 20080501 |
| Clodronate inhibits angiogenesis in vitro and in vivo. | Oncology reports 20080501 |
| Gut ischemia/reperfusion induced acute lung injury is an alveolar macrophage dependent event. | The Journal of trauma 20080501 |
| The fate of MAb-targeted Cd(125m)Te/ZnS nanoparticles in vivo. | Nuclear medicine and biology 20080501 |
| Differential roles of phosphatidylinositol 3-kinase/akt pathway in retinal ganglion cell survival in rats with or without acute ocular hypertension. | Neuroscience 20080422 |
| Combined use of zoledronic acid and 153Sm-EDTMP in hormone-refractory prostate cancer patients with bone metastases. | European journal of nuclear medicine and molecular imaging 20080401 |
| Protective effects of elevated endogenous surfactant pools to injurious mechanical ventilation. | American journal of physiology. Lung cellular and molecular physiology 20080401 |
| FRAX and the assessment of fracture probability in men and women from the UK. | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20080401 |
| Immediate mineralocorticoid receptor blockade improves myocardial infarct healing by modulation of the inflammatory response. | Hypertension (Dallas, Tex. : 1979) 20080401 |
| Targeting tumor-associated macrophages in an orthotopic murine model of diffuse malignant mesothelioma. | Molecular cancer therapeutics 20080401 |
| Bisphosphonate-induced ATP analog formation and its effect on inhibition of cancer cell growth. | Anti-cancer drugs 20080401 |
| Osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphonates: definition and management of the risk related to zoledronic acid. | Clinical lymphoma & myeloma 20080401 |
| Use of ibandronate in the prevention of skeletal events in metastatic breast cancer. | Therapeutics and clinical risk management 20080401 |
| A Phase II trial evaluating the palliative benefit of second-line oral ibandronate in breast cancer patients with either a skeletal related event (SRE) or progressive bone metastases (BM) despite standard bisphosphonate (BP) therapy. | Breast cancer research and treatment 20080301 |
| Guidance on the use of bisphosphonates in solid tumours: recommendations of an international expert panel. | Annals of oncology : official journal of the European Society for Medical Oncology 20080301 |
| Abdominal aortic calcification detected on lateral spine images from a bone densitometer predicts incident myocardial infarction or stroke in older women. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20080301 |
| Macrophages contribute to the development of renal fibrosis following ischaemia/reperfusion-induced acute kidney injury. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20080301 |
| Bone degeneration and recovery after early and late bisphosphonate treatment of ovariectomized wistar rats assessed by in vivo micro-computed tomography. | Calcified tissue international 20080301 |
| Morphine induces defects in early response of alveolar macrophages to Streptococcus pneumoniae by modulating TLR9-NF-kappa B signaling. | Journal of immunology (Baltimore, Md. : 1950) 20080301 |
| Relative contribution of direct and indirect allorecognition in developing tolerance after liver transplantation. | Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20080301 |
| The role of macrophages in early healing of a tendon graft in a bone tunnel. | The Journal of bone and joint surgery. American volume 20080301 |
| Tumor-associated Hypercalcemia in a patient with Paget's disease. | The Kaohsiung journal of medical sciences 20080301 |
| [Osteonecrosis of the jaw developing during bisphosphonate treatment]. | Magyar onkologia 20080301 |
| Prolonged islet allograft survival in diabetic mice upon macrophage depletion by clodronate-loaded erythrocytes. | Transplantation 20080227 |
| Interaction between macrophages, TGF-beta1, and the COX-2 pathway during the inflammatory phase of skeletal muscle healing after injury. | Journal of cellular physiology 20080201 |
| Year in review in Intensive Care Medicine, 2007. I. Experimental studies. Clinical studies: brain injury and neurology, renal failure and endocrinology. | Intensive care medicine 20080201 |
| Mucosal damage and neutropenia are required for Candida albicans dissemination. | PLoS pathogens 20080201 |
| Antitumor activity of liposomal prednisolone phosphate depends on the presence of functional tumor-associated macrophages in tumor tissue. | Neoplasia (New York, N.Y.) 20080201 |
| Treatment of breast cancer with bone metastasis: bisphosphonate treatment - current and future. | International journal of clinical oncology 20080201 |
| Zoledronic acid in the management of metastatic bone disease. | Therapeutics and clinical risk management 20080201 |
| Effects of depletion of neutrophils or macrophages on the inflammatory response induced by metalloelastase (MMP-12) in mice airways. | European journal of pharmacology 20080128 |
| Urokinase-type plasminogen activator plays essential roles in macrophage chemotaxis and skeletal muscle regeneration. | Journal of immunology (Baltimore, Md. : 1950) 20080115 |
| Small artery remodeling and erythrocyte deformability in L-NAME-induced hypertension: role of transglutaminases. | Journal of vascular research 20080101 |
| Bisphosphonates for bone metastatic disease from breast cancer: clinical practice in the Czech Republic. | Clinical & experimental metastasis 20080101 |
| Macrophage involvement in the kidney repair phase after ischaemia/reperfusion injury. | The Journal of pathology 20080101 |
| Extracellular calcium increases bisphosphonate-induced growth inhibition of breast cancer cells. | Breast cancer research : BCR 20080101 |
| Toward more effective gene delivery. | Genome biology 20080101 |
| Going beyond efficacy: strategies for cancer pain management. | Current oncology (Toronto, Ont.) 20080101 |
| A primer of bone metastases management in breast cancer patients. | Current oncology (Toronto, Ont.) 20080101 |
| PPAR Gamma: Coordinating Metabolic and Immune Contributions to Female Fertility. | PPAR research 20080101 |
| Alendronate decreases orthotopic PC-3 prostate tumor growth and metastasis to prostate-draining lymph nodes in nude mice. | BMC cancer 20080101 |
| Effects of Kupffer cell-depletion on Concanavalin A-induced hepatitis. | Cellular immunology 20080101 |
| Emerging role of bisphosphonates in the clinic--antitumor activity and prevention of metastasis to bone. | Cancer treatment reviews 20080101 |
| Antitumoral and antiangiogenic efficacy of bisphosphonates in vitro and in a murine RENCA model. | Anticancer research 20080101 |
| Cost-effectiveness of oral clodronate compared with oral ibandronate, intravenous zoledronate or intravenous pamidronate in breast cancer patients. | The Journal of international medical research 20080101 |
| Application of UV-derivative spectrophotometry for determination of some bisphosphonates drugs in pharmaceutical formulations. | Acta poloniae pharmaceutica 20080101 |
| Roles of PI3K and JAK pathways in viability of retinal ganglion cells after acute elevation of intraocular pressure in rats with different autoimmune backgrounds. | BMC neuroscience 20080101 |
| Are new-generation bisphosphonates effective for the inhibition of calcium oxalate stone formation in a rat model? | Urologia internationalis 20080101 |
| Predicting in vivo efficacy of potential restenosis therapies by cell culture studies: species-dependent susceptibility of vascular smooth muscle cells. | The open cardiovascular medicine journal 20080101 |
| Role of pulmonary intravascular macrophages in endotoxin-induced lung inflammation and mortality in a rat model. | Respiratory research 20080101 |
| Modulation of macrophage activation state protects tissue from necrosis during critical limb ischemia in thrombospondin-1-deficient mice. | PloS one 20080101 |
| A role for non-antimicrobial actions of tetracyclines in combating oxidative stress in periodontal and metabolic diseases: a literature review. | The open dentistry journal 20080101 |
| Th1- and Th2-related chemokine and chemokine receptor expression on the ocular surface in endotoxin-induced uveitis. | Molecular vision 20080101 |
| Long Term Cyclic Pamidronate Reduces Bone Growth by Inhibiting Osteoclast Mediated Cartilage-to-Bone Turnover in the Mouse. | The open orthopaedics journal 20080101 |
| Analgesic efficacy of zoledronic acid and its effect on functional status of prostate cancer patients with metastasis. | Patient preference and adherence 20080101 |
| Quality of life measurement in bone metastases: A literature review. | Journal of pain research 20080101 |
| Oncolytic viruses: do they have a role in anti-cancer therapy? | Clinical medicine. Oncology 20080101 |
| A prospective, multicenter, open-label trial of zoledronic acid in patients with hormone refractory prostate cancer. | Yonsei medical journal 20071231 |
| Pathophysiology, risk factors and management of bisphosphonate-associated osteonecrosis of the jaw: Is there a diverse relationship of amino- and non-aminobisphosphonates? | Critical reviews in oncology/hematology 20071201 |
| Inflammatory stimuli from macrophages and cancer cells synergistically promote tumor growth and angiogenesis. | Cancer science 20071201 |
| Macrophages are important determinants of acute ocular HSV-1 infection in immunized mice. | Investigative ophthalmology & visual science 20071201 |
| Antiangiogenic effects of bisphosphonates on laser-induced choroidal neovascularization in mice. | Investigative ophthalmology & visual science 20071201 |
| Evidence based medicine and effective interventions of pharmacological therapy for the prevention of osteoporotic fractures. | Minerva endocrinologica 20071201 |
| Osteoporosis in the aging male: treatment options. | Clinical interventions in aging 20071201 |
| Local peroperative treatment with a bisphosphonate improves the fixation of total knee prostheses: a randomized, double-blind radiostereometric study of 50 patients. | Acta orthopaedica 20071201 |
| Different responses of macrophages in retinal ganglion cell survival after acute ocular hypertension in rats with different autoimmune backgrounds. | Experimental eye research 20071101 |
| JAK/STAT pathway mediates retinal ganglion cell survival after acute ocular hypertension but not under normal conditions. | Experimental eye research 20071101 |
| The use of bone markers in a 6-week study to assess the efficacy of oral clodronate in patients with metastatic bone disease. | Calcified tissue international 20071101 |
| [Mandible osteonechrosis associated to bisfosfonates]. | Ginecologia y obstetricia de Mexico 20071101 |
| Bisphosphonate therapy for children and adolescents with secondary osteoporosis. | The Cochrane database of systematic reviews 20071017 |
| Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis. | Journal of hepatology 20071001 |
| Urokinase-type plasminogen activator and macrophages are required for skeletal muscle hypertrophy in mice. | American journal of physiology. Cell physiology 20071001 |
| Alveolar macrophages are necessary for the systemic inflammation of acute alveolar hypoxia. | Journal of applied physiology (Bethesda, Md. : 1985) 20071001 |
| A double-blind placebo-controlled study of intravenous clodronate for prevention of steroid-induced bone loss in inflammatory bowel disease. | Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20071001 |
| Ambient particulate matter accelerates coagulation via an IL-6-dependent pathway. | The Journal of clinical investigation 20071001 |
| Depletion of peripheral macrophages and brain microglia increases brain tumor titers of oncolytic viruses. | Cancer research 20071001 |
| Use of zoledronic acid in the treatment of Paget's disease. | Therapeutics and clinical risk management 20071001 |
| Chemotactic effect of ciliary neurotrophic factor on macrophages in retinal ganglion cell survival and axonal regeneration. | Investigative ophthalmology & visual science 20070901 |
| Age-dependent increase in green autofluorescence of blood erythrocytes. | Journal of biosciences 20070901 |
| Fracture prevention in postmenopausal women. | BMJ clinical evidence 20070901 |
| High concentrations of pamidronate in bone weaken the mechanical properties of intact femora in a rat model. | Yonsei medical journal 20070831 |
| Development and application of a high-performance liquid chromatography-mass spectrometry method to determine alendronate in human urine. | Journal of chromatography. A 20070810 |
| Role of the cysteine protease cathepsin S in neuropathic hyperalgesia. | Pain 20070801 |
| Alveolar macrophage depletion is associated with increased surfactant pool sizes in adult rats. | Journal of applied physiology (Bethesda, Md. : 1985) 20070801 |
| Targeting tumor-associated macrophages and inhibition of MCP-1 reduce angiogenesis and tumor growth in a human melanoma xenograft. | The Journal of investigative dermatology 20070801 |
| Induction of serum IL-18 with Propionibacterium acnes and lipopolysaccharide in phagocytic macrophage-inactivated mice. | Journal of leukocyte biology 20070801 |
| Synthesis and biological evaluation of 9-deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid as multi-substrate analogue inhibitors of PNP. | Bioorganic & medicinal chemistry letters 20070801 |
| PI3K/akt, JAK/STAT and MEK/ERK pathway inhibition protects retinal ganglion cells via different mechanisms after optic nerve injury. | The European journal of neuroscience 20070801 |
| A review of the literature on osteonecrosis of the jaw in patients with osteoporosis treated with oral bisphosphonates: prevalence, risk factors, and clinical characteristics. | Clinical therapeutics 20070801 |
| Platinum complexes can inhibit matrix metalloproteinase activity: platinum-diethyl[(methylsulfinyl)methyl]phosphonate complexes as inhibitors of matrix metalloproteinases 2, 3, 9, and 12. | Journal of medicinal chemistry 20070726 |
| The spine in Paget's disease. | Skeletal radiology 20070701 |
| Reduction in alveolar macrophages attenuates acute ventilator induced lung injury in rats. | Intensive care medicine 20070701 |
| Oral sodium clodronate induced osteonecrosis of the jaw in a patient with myeloma. | European journal of haematology 20070701 |
| Potential use of bisphosphonates in the prevention of metastases in early-stage breast cancer. | Clinical breast cancer 20070701 |
| Murine alveolar macrophages limit replication of vaccinia virus. | Virology 20070620 |
| Meta-analysis of clodronate and breast cancer survival. | British journal of cancer 20070618 |
| Bisphosphonates: are they standard of care for the treatment of breast cancer? | British journal of cancer 20070618 |
| American Society of Clinical Oncology 2007 clinical practice guideline update on the role of bisphosphonates in multiple myeloma. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070610 |
| A 4-year treatment with clodronate plus calcium and vitamin D supplements does not improve bone mass in primary biliary cirrhosis. | Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20070601 |
| Nanoparticulate carriers for the treatment of coronary restenosis. | International journal of nanomedicine 20070601 |
| Biological targets for isatin and its analogues: Implications for therapy. | Biologics : targets & therapy 20070601 |
| Oral sodium clodronate for nonmetastatic prostate cancer--results of a randomized double-blind placebo-controlled trial: Medical Research Council PR04 (ISRCTN61384873). | Journal of the National Cancer Institute 20070516 |
| The CCL3 family of chemokines and innate immunity cooperate in vivo in the eradication of an established lymphoma xenograft by rituximab. | Journal of immunology (Baltimore, Md. : 1950) 20070515 |
| Imaging the modulation of adenoviral kinetics and biodistribution for cancer gene therapy. | Molecular therapy : the journal of the American Society of Gene Therapy 20070501 |
| In vivo gene delivery and expression by bacteriophage lambda vectors. | Journal of applied microbiology 20070501 |
| Pertussis toxin targets airway macrophages to promote Bordetella pertussis infection of the respiratory tract. | Infection and immunity 20070401 |
| Current management for late normal tissue injury: radiation-induced fibrosis and necrosis. | Seminars in radiation oncology 20070401 |
| Managing metastatic bone pain: the role of bisphosphonates. | Journal of pain and symptom management 20070401 |
| [Relevance of bisphosphonate long-term therapy in radiation therapy of endosteal jaw metastases]. | Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20070401 |
| Amino-bisphosphonates decrease hTERT gene expression in breast cancer in vitro. | Aging clinical and experimental research 20070401 |
| Comparative study of the protective effect of different intravenous bisphosphonates on the decrease in bone mineral density in patients submitted to radical prostatectomy undergoing androgen deprivation therapy. A prospective open-label controlled study. | International journal of urology : official journal of the Japanese Urological Association 20070401 |
| Macrophage depletion in the murine olfactory epithelium leads to increased neuronal death and decreased neurogenesis. | The Journal of comparative neurology 20070310 |
| Macrophage depletion alters the blood-nerve barrier without affecting Schwann cell function after neural injury. | Journal of neuroscience research 20070301 |
| Severe osteomyelitis of the mandible associated with the use of non-nitrogen-containing bisphosphonate (disodium clodronate): report of a case. | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20070301 |
| Bisphosphonates: mode of action and pharmacology. | Pediatrics 20070301 |
| New multifunctional anti-osteolytic releasing bioabsorbable implant. | The Journal of craniofacial surgery 20070301 |
| The differential effects of bisphosphonates, SERMS (selective estrogen receptor modulators), and parathyroid hormone on bone remodeling in osteoporosis. | Clinical interventions in aging 20070301 |
| Quarterly intravenous injection of ibandronate to treat osteoporosis in postmenopausal women. | Clinical interventions in aging 20070301 |
| Antitumor effects of clinical dosing regimens of bisphosphonates in experimental breast cancer bone metastasis. | Journal of the National Cancer Institute 20070221 |
| Differential effects of bisphosphonates on breast cancer cell lines. | Cancer letters 20070208 |
| Kupffer cells are obligatory for Plasmodium yoelii sporozoite infection of the liver. | Cellular microbiology 20070201 |
| Histidine decarboxylase-stimulating and inflammatory effects of alendronate in mice: involvement of mevalonate pathway, TNFalpha, macrophages, and T-cells. | International immunopharmacology 20070201 |
| [Experimental study for thrombocytopenic purpura therapy by targeting macrophages in liver and spleen]. | Zhongguo shi yan xue ye xue za zhi 20070201 |
| New multidisciplinary prostate bone metastases clinic: first of its kind in Canada. | Current oncology (Toronto, Ont.) 20070201 |
| Clodronate reduces the incidence of fractures in community-dwelling elderly women unselected for osteoporosis: results of a double-blind, placebo-controlled randomized study. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20070101 |
| Reduction of renal fibrosis as a result of liposome encapsulated clodronate induced macrophage depletion after unilateral ureteral obstruction in rats. | Nephron. Experimental nephrology 20070101 |
| C-reactive protein-mediated suppression of nephrotoxic nephritis: role of macrophages, complement, and Fcgamma receptors. | Journal of immunology (Baltimore, Md. : 1950) 20070101 |
| Crucial role of macrophages in matrix metalloproteinase-mediated cartilage destruction during experimental osteoarthritis: involvement of matrix metalloproteinase 3. | Arthritis and rheumatism 20070101 |
| Mechanisms of osteopontin and CD44 as metastatic principles in prostate cancer cells. | Molecular cancer 20070101 |
| The Interleukin-6 inflammation pathway from cholesterol to aging--role of statins, bisphosphonates and plant polyphenols in aging and age-related diseases. | Immunity & ageing : I & A 20070101 |
| Clinical usefulness of bisphosphonates in oncology: treatment of bone metastases, antitumoral activity and effect on bone resorption markers. | The International journal of biological markers 20070101 |
| The boy who refused an IV: a case report of subcutaneous clodronate for bone pain in a child with Ewing Sarcoma. | Journal of medical case reports 20070101 |
| Clodronic acid in the treatment of postmenopausal osteoporosis. | Clinical drug investigation 20070101 |
| [Avascular jaw osteonecrosis in a hemodialysis patient treated with bisphosphonates]. | Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia 20070101 |
| Rapid determination of bisphosphonates by ion chromatography with indirect UV detection. | Journal of chromatographic science 20070101 |
| Multiple myeloma/hypercalcemia. | Arthritis research & therapy 20070101 |
| Pharmacologic modulation of clodronate in local therapy of periodontal and implant inflammation. | International journal of immunopathology and pharmacology 20070101 |
| Microglial cells in astroglial cultures: a cautionary note. | Journal of neuroinflammation 20070101 |
| Proteinases in the joint: clinical relevance of proteinases in joint destruction. | Arthritis research & therapy 20070101 |
| Immunological intervention in human diseases. | Journal of translational medicine 20070101 |
| Effect of bisphosphonates on nitric oxide production by inflammatory activated chondrocytes. | Clinical and experimental rheumatology 20070101 |
| Cells of the synovium in rheumatoid arthritis. Macrophages. | Arthritis research & therapy 20070101 |
| Adverse effects of bisphosphonates: current issues. | The journal of supportive oncology 20070101 |
| Treatment of bone metastases and bone pain with bisphosphonates. | Supportive cancer therapy 20070101 |
| Use of bisphosphonates in prostate cancer: Current status. | Indian journal of urology : IJU : journal of the Urological Society of India 20070101 |
| Complicated septic shock caused by Achromobacter xylosoxidans bacteremia in a patient with acute lymphoblastic leukaemia. | The Libyan journal of medicine 20070101 |
| Clodronate acts on human osteoclastic cell proliferation, differentiation and function in a bioreversible manner. | Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases 20070101 |
| Synthesis of methylene- and difluoromethylenephosphonate analogues of uridine-4-phosphate and 3-deazauridine-4-phosphate. | The Journal of organic chemistry 20061208 |
| Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced lung injury. | American journal of physiology. Lung cellular and molecular physiology 20061201 |
| In CD4+ T-cell-induced diabetes, macrophages are the final effector cells that mediate islet beta-cell killing: studies from an acute model. | The American journal of pathology 20061201 |
| Tumor necrosis factor alpha and macrophages in the brain of herpes simplex virus type 1-infected BALB/c mice. | Journal of neurovirology 20061201 |
| Postoperative clodronate decreases prosthetic migration: 4-year follow-up of a randomized radiostereometric study of 50 total knee patients. | Acta orthopaedica 20061201 |
| Host macrophages produce diacetylspermine related with tumorigenesis. | Cancer letters 20061108 |
| Alveolar macrophage activation is a key initiation signal for acute lung ischemia-reperfusion injury. | American journal of physiology. Lung cellular and molecular physiology 20061101 |
| A new model for limbal transplantation using E-GFP for follow-up of transplant survival. | Experimental eye research 20061101 |
| Intracorneal instillation of latex beads induces macrophage-dependent protection against Acanthamoeba keratitis. | Investigative ophthalmology & visual science 20061101 |
| Phase II trial evaluating the palliative benefit of second-line zoledronic acid in breast cancer patients with either a skeletal-related event or progressive bone metastases despite first-line bisphosphonate therapy. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20061020 |
| Synthesis of bisphosphonate derivatives of ATP by T4 RNA ligase. | FEBS letters 20061016 |
| Oral bisphosphonates as adjuvant therapy for operable breast cancer. | Clinical cancer research : an official journal of the American Association for Cancer Research 20061015 |
| Evaluation of liposomal clodronate in experimental spontaneous autoimmune hemolytic anemia in dogs. | Experimental hematology 20061001 |
| Antioxidant effect of bisphosphonates and simvastatin on chondrocyte lipid peroxidation. | Biochemical and biophysical research communications 20060922 |
| Alveolar macrophages suppress non-specific inflammation caused by inhalation challenge with trimellitic anhydride conjugated to albumin. | Archives of toxicology 20060901 |
| Bone complications in multiple myeloma. | Cancer biology & therapy 20060901 |
| The effect of clodronate on bone mineral density and serum osteocalcin in postmenopausal women with osteopenia - a prospective, randomized, placebo-controlled study. | Ortopedia, traumatologia, rehabilitacja 20060831 |
| Targeting study of gelatin adsorbed clodronate in reticuloendothelial system and its potential application in immune thrombocytopenic purpura of rat model. | Journal of controlled release : official journal of the Controlled Release Society 20060828 |
| A systematic review of the effectiveness of docetaxel and mitoxantrone for the treatment of metastatic hormone-refractory prostate cancer. | British journal of cancer 20060821 |
| Clodronate-liposome-mediated depletion of tumour-associated macrophages: a new and highly effective antiangiogenic therapy approach. | British journal of cancer 20060807 |
| Efficient gene transfer into macrophages and dendritic cells by in vivo gene delivery with mannosylated lipoplex via the intraperitoneal route. | The Journal of pharmacology and experimental therapeutics 20060801 |
| Clodronate inhibits PGE(2) production in compressed periodontal ligament cells. | Journal of dental research 20060801 |
| Potential role of microglia in retinal blood vessel formation. | Investigative ophthalmology & visual science 20060801 |
| Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation. | The Journal of clinical investigation 20060801 |
| Clodronate alleviates cachexia and prolongs survival in nude mice xenografted with an anaplastic thyroid carcinoma cell line. | The Journal of endocrinology 20060801 |
| Macrophages inhibit neovascularization in a murine model of age-related macular degeneration. | PLoS medicine 20060801 |
| The use of bisphosphonates in men with hormone-refractory prostate cancer: a systematic review of randomized trials. | The Canadian journal of urology 20060801 |
| Flow-dependent remodeling of small arteries in mice deficient for tissue-type transglutaminase: possible compensation by macrophage-derived factor XIII. | Circulation research 20060707 |
| Effect of bisphosphonates on the stimulation of macrophages by alumina ceramic particles: a comparison with ultra-high-molecular-weight polyethylene. | Journal of materials science. Materials in medicine 20060701 |
| Effects of alveolar macrophage depletion on liposomal vaccine protection against respiratory syncytial virus (RSV). | Clinical and experimental immunology 20060701 |
| Macrophages are vital in spontaneous intraocular tumor eradication. | Investigative ophthalmology & visual science 20060701 |
| Effects of macrophage inducible nitric oxide synthase in murine septic lung injury. | American journal of physiology. Lung cellular and molecular physiology 20060601 |
| Macrophages and skeletal muscle regeneration: a clodronate-containing liposome depletion study. | American journal of physiology. Regulatory, integrative and comparative physiology 20060601 |
| Pharmacologic management of complex regional pain syndrome. | The Clinical journal of pain 20060601 |
| Fracture prevention in postmenopausal women. | Clinical evidence 20060601 |
| Mutual augmentation of the induction of the histamine-forming enzyme, histidine decarboxylase, between alendronate and immuno-stimulants (IL-1, TNF, and LPS), and its prevention by clodronate. | Toxicology and applied pharmacology 20060515 |
| Novel insights into actions of bisphosphonates on bone: differences in interactions with hydroxyapatite. | Bone 20060501 |
| Relative binding affinities of bisphosphonates for human bone and relationship to antiresorptive efficacy. | Bone 20060501 |
| Macrophages contribute to the initiation of ischaemic acute renal failure in rats. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20060501 |
| Bisphosphonates for malignancy-related bone disease: current status, future developments. | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20060501 |
| Cytosolic entry of bisphosphonate drugs requires acidification of vesicles after fluid-phase endocytosis. | Molecular pharmacology 20060501 |
| Antigen sensitization modulates alveolar macrophage functions in an asthma model. | American journal of physiology. Lung cellular and molecular physiology 20060501 |
| Mutation of mouse Mayp/Pstpip2 causes a macrophage autoinflammatory disease. | Blood 20060415 |
| -511 C/T IL1B gene polymorphism is associated to resistance to bisphosphonates treatment in Paget disease of bone. | Bone 20060401 |
| Alendronate in bone cement: fatigue life degraded by liquid, not by powder. | Clinical orthopaedics and related research 20060401 |
| Liver-stage development of Plasmodium falciparum, in a humanized mouse model. | The Journal of infectious diseases 20060401 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20060401 |
| Bisphosphonates: from bench to bedside. | Annals of the New York Academy of Sciences 20060401 |
| Role of bisphosphonates for the management of skeletal complications and bone pain from skeletal metastases. | Supportive cancer therapy 20060401 |
| Synthesis and biological evaluation of 9-(5',5'-difluoro-5'-phosphonopentyl)guanine derivatives for PNP-inhibitors. | Bioorganic & medicinal chemistry 20060301 |
| Kupffer cells abrogate cholestatic liver injury in mice. | Gastroenterology 20060301 |
| Ibandronate: the first once-monthly oral bisphosphonate for treatment of postmenopausal osteoporosis. | Therapeutics and clinical risk management 20060301 |
| Differences between the bisphosphonates for the prevention and treatment of osteoporosis. | Therapeutics and clinical risk management 20060301 |
| Accelerated macrophage apoptosis induces autoantibody formation and organ damage in systemic lupus erythematosus. | Journal of immunology (Baltimore, Md. : 1950) 20060215 |
| Inhibition of adenosine kinase by phosphonate and bisphosphonate derivatives. | Molecular and cellular biochemistry 20060201 |
| Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ T cell crosspriming in vivo. | Immunity 20060201 |
| Anti-hip fracture efficacy of biophosphonates: a Bayesian analysis of clinical trials. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20060201 |
| [Osteonecrosis of the jaw in the course of multiple myeloma treatment and bisphosphonate administration]. | Vnitrni lekarstvi 20060201 |
| Lipid emulsions potently increase transgene expression in hepatocytes after adenoviral transfer. | Molecular therapy : the journal of the American Society of Gene Therapy 20060101 |
| Identification of a potent inverse agonist at a constitutively active mutant of human P2Y12 receptor. | Molecular pharmacology 20060101 |
| The use of bisphosphonates in palliative treatment of bone metastases in a terminally ill, oncological elderly population. | Archives of gerontology and geriatrics 20060101 |
| Administration of zoledronic acid enhances the effects of docetaxel on growth of prostate cancer in the bone environment. | BMC cancer 20060101 |
| Additive growth inhibitory effects of ibandronate and antiestrogens in estrogen receptor-positive breast cancer cell lines. | Breast cancer research : BCR 20060101 |
| The effect of bisphosphonates on gene expression: GAPDH as a housekeeping or a new target gene? | BMC cancer 20060101 |
| Determinants of adherence to osteoporosis treatment in clinical practice. | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20060101 |
| Synthesis of novel (1-alkanoyloxy-4-alkanoylaminobutylidene)-1,1-bisphosphonic acid derivatives. | Beilstein journal of organic chemistry 20060101 |
| Reduction in bone relapse and improved survival with oral clodronate for adjuvant treatment of operable breast cancer [ISRCTN83688026]. | Breast cancer research : BCR 20060101 |
| Tumor-induced hypophosphatemic osteomalacia associated with tertiary hyperparathyroidism: a case report. | Il Giornale di chirurgia 20060101 |
| Bisphosphonate pretreatment attenuates hungry bone syndrome postoperatively in subjects with primary hyperparathyroidism. | Journal of bone and mineral metabolism 20060101 |
| Folate-targeted immunotherapy effectively treats established adjuvant and collagen-induced arthritis. | Arthritis research & therapy 20060101 |
| Effects of bisphosphonates on prostaglandin E2 and thromboxane B2 production in human whole blood and monocytes stimulated by lipopolysaccharide and A23187. | Methods and findings in experimental and clinical pharmacology 20060101 |
| Leader (L) and L* proteins of Theiler's murine encephalomyelitis virus (TMEV) and their regulation of the virus' biological activities. | Journal of neuroinflammation 20060101 |
| The role of bisphosphonates in early breast cancer. | The oncologist 20060101 |
| Ibandronate: its role in metastatic breast cancer. | The oncologist 20060101 |
| Bisphosphonate-associated osteonecrosis of the jaw: the rheumatologist's role. | Arthritis research & therapy 20060101 |
| Cartilage oligomeric matrix protein (COMP) is modified by intra-articular liposomal clodronate in an experimental model of arthritis. | Clinical and experimental rheumatology 20060101 |
| Parathyroid cancer: etiology, clinical presentation and treatment. | Anticancer research 20060101 |
| Antibody-induced arthritis: disease mechanisms and genes involved at the effector phase of arthritis. | Arthritis research & therapy 20060101 |
| The incidence of jaw osteonecrosis in multiple myeloma patients treated with bisphosphonates. | Acta poloniae pharmaceutica 20060101 |
| Bisphosphonates as adjuvant therapy for breast cancer. | Women's health (London, England) 20060101 |
| Osteoclast responses to lipopolysaccharide, parathyroid hormone and bisphosphonates in neonatal murine calvaria analyzed by laser scanning confocal microscopy. | The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20051201 |
| Acute CD4+ T lymphocyte-dependent interleukin-1-driven arthritis selectively requires interleukin-2 and interleukin-4, joint macrophages, granulocyte-macrophage colony-stimulating factor, interleukin-6, and leukemia inhibitory factor. | Arthritis and rheumatism 20051201 |
| Acute renal effects of intravenous bisphosphonates in the rat. | Basic & clinical pharmacology & toxicology 20051201 |
| In vitro comparison of clodronate, pamidronate and zoledronic acid effects on rat osteoclasts and human stem cell-derived osteoblasts. | Basic & clinical pharmacology & toxicology 20051201 |
| Endogenous opioid analgesia in peripheral tissues and the clinical implications for pain control. | Therapeutics and clinical risk management 20051201 |
| Macrophages are involved in hexachlorobenzene-induced adverse immune effects. | Toxicology and applied pharmacology 20051115 |
| Early interaction of Yersinia pestis with APCs in the lung. | Journal of immunology (Baltimore, Md. : 1950) 20051115 |
| Bisphosphonates for treatment and prevention of bone metastases. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20051110 |
| Aging of red blood cells and impaired erythropoiesis following prolonged administration of dichloromethylene diphosphonate containing liposomes in rats. | European journal of haematology 20051101 |
| Infiltration of COX-2-expressing macrophages is a prerequisite for IL-1 beta-induced neovascularization and tumor growth. | The Journal of clinical investigation 20051101 |
| Involvement of neutrophil recruitment and protease-activated receptor 2 activation in the induction of IL-18 in mice. | Journal of leukocyte biology 20051101 |
| Intermittent intramuscular clodronate therapy: a valuable option for older osteoporotic women. | Age and ageing 20051101 |
| S0307. Phase III trial of bisphosphonates as adjuvant therapy for primary breast cancer. | Clinical advances in hematology & oncology : H&O 20051101 |
| Real-time in vivo imaging of apoptotic cell membrane changes in monocytes and macrophages. | Apoptosis : an international journal on programmed cell death 20051001 |
| Pilot studies of the effect of zoledronic acid (Zometa) on tumor-derived cells ex vivo in the ATP-based tumor chemosensitivity assay. | Anti-cancer drugs 20051001 |
| Comparative appraisal of clodronate, aspirin and dexamethasone as agents reducing alendronate-induced inflammation in a murine model. | Basic & clinical pharmacology & toxicology 20051001 |
| A crucial role for macrophages in the pathology of K/B x N serum-induced arthritis. | European journal of immunology 20051001 |
| Serum tartrate-resistant acid phosphatase 5b in monitoring bisphosphonate treatment with clodronate: a comparison with urinary N-terminal telopeptide of type I collagen and serum type I procollagen amino-terminal propeptide. | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20050901 |
| Histological analysis of CD11c-DTR/GFP mice after in vivo depletion of dendritic cells. | Clinical and experimental immunology 20050901 |
| An innate immune system cell is a major determinant of species-related susceptibility differences to fungal pneumonia. | Journal of immunology (Baltimore, Md. : 1950) 20050901 |
| Pulmonary aspiration: new therapeutic approaches in the experimental model. | Anesthesiology 20050901 |
| Microglia stimulate the invasiveness of glioma cells by increasing the activity of metalloprotease-2. | Journal of neuropathology and experimental neurology 20050901 |
| Prevention and treatment of corticosteroid-induced osteoporosis. | Yonsei medical journal 20050831 |
| Bisphosphonates decrease telomerase activity and hTERT expression in MCF-7 breast cancer cells. | Molecular and cellular endocrinology 20050830 |
| Influence of bisphosphonates on the production of pro-inflammatory cytokines by activated human articular chondrocytes. | Cytokine 20050821 |
| Myeloma bone disease: pathophysiology and management. | Annals of oncology : official journal of the European Society for Medical Oncology 20050801 |
| Three-year oral clodronate treatment does not impair mineralization of newly formed bone--a histomorphometric study. | Calcified tissue international 20050801 |
| Bone loss and the aromatase inhibitors. | British journal of cancer 20050801 |
| Role of gut macrophages in mice orally contaminated with scrapie or BSE. | International journal of pharmaceutics 20050725 |
| Bisphosphonates for breast cancer. | The Cochrane database of systematic reviews 20050720 |
| Blood-derived macrophages infiltrate the retina and activate Muller glial cells under experimental choroidal neovascularization. | Experimental eye research 20050701 |
| The effect of clodronate on the integrity and viability of rat small intestine in vitro-a comparison with EDTA. | Biological & pharmaceutical bulletin 20050701 |
| Inhibition of inflammatory and bone-resorption-inhibitory effects of alendronate by etidronate. | Calcified tissue international 20050601 |
| Intravital observation of Plasmodium berghei sporozoite infection of the liver. | PLoS biology 20050601 |
| Mechanism of osteoclast mediated bone resorption--rationale for the design of new therapeutics. | Advanced drug delivery reviews 20050525 |
| Monocyte chemoattractant protein-1 regulation of blood-brain barrier permeability. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20050501 |
| Iron- and inflammation-induced hepcidin gene expression in mice is not mediated by Kupffer cells in vivo. | Hepatology (Baltimore, Md.) 20050501 |
| Bisphosphonates in breast cancer. | Annals of oncology : official journal of the European Society for Medical Oncology 20050501 |
| The role of bisphosphonates in the treatment of prostate cancer. | BJU international 20050501 |
| The issue of renal safety of zoledronic acid from a nephrologist's point of view. | The oncologist 20050501 |
| 'Safety and convenience of a 15-minute infusion of zoledronic acid': not so safe. | The oncologist 20050501 |
| Macrophage ablation attenuates adenoviral vector-induced pancreatitis. | Surgery 20050501 |
| [Bisphosphonates: the molecular targets and mechanisms of action]. | Clinical calcium 20050501 |
| The reactive D-glucopyranose moiety of streptozotocin is responsible for activation of macrophages and subsequent stimulation of CD8+ T cells. | Chemical research in toxicology 20050501 |
| Silica particles enhance peripheral thrombosis: key role of lung macrophage-neutrophil cross-talk. | American journal of respiratory and critical care medicine 20050415 |
| Structures of bisphosphonate metal complexes: zinc and cadmium complexes of clodronate and its partial ester derivatives. | Inorganic chemistry 20050404 |
| Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: role of macrophages. | American journal of physiology. Renal physiology 20050401 |
| Bacterial adhesion to bisphosphonate coated hydroxyapatite. | Journal of materials science. Materials in medicine 20050401 |
| Should oral bisphosphonates be standard of care in women with early breast cancer? | Breast cancer research and treatment 20050401 |
| [What is the place of diphosphonates in the treatment of complex regional pain syndrome I?]. | Annales de readaptation et de medecine physique : revue scientifique de la Societe francaise de reeducation fonctionnelle de readaptation et de medecine physique 20050401 |
| Clodronate in the prevention and treatment of skeletal metastasis. | Expert review of anticancer therapy 20050401 |
| Suppression of macrophage infiltration into the conjunctiva by clodronate liposomes in experimental immune-mediated blepharoconjunctivitis. | Cell biology international 20050401 |
| Optimizing the management of postmenopausal osteoporosis with bisphosphonates: the emerging role of intermittent therapy. | Clinical therapeutics 20050401 |
| Management of bone metastases in breast cancer. | Current treatment options in oncology 20050301 |
| Interleukin-6 and osteoprotegerin systems in Paget's disease of bone: relationship to risedronate treatment. | Bone 20050301 |
| Clodronate treatment influences MMP-2 associated outcome in node positive breast cancer. | Breast cancer research and treatment 20050301 |
| [Pharmacological treatment of osteitis deformans (Paget's bone disease)]. | Ugeskrift for laeger 20050227 |
| Intratracheal administration of liposomal clodronate accelerates alveolar macrophage reconstitution following fetal liver transplantation. | Journal of leukocyte biology 20050201 |
| Major healing of refractory mandible osteoradionecrosis after treatment combining pentoxifylline and tocopherol: a phase II trial. | Head & neck 20050201 |
| Macrophage-depletion induced impairment of experimental CNS remyelination is associated with a reduced oligodendrocyte progenitor cell response and altered growth factor expression. | Neurobiology of disease 20050201 |
| Bone health in women with early-stage breast cancer. | Clinical breast cancer 20050201 |
| Evolving role of bisphosphonates in women undergoing treatment for localized and advanced breast cancer. | Clinical breast cancer 20050201 |
| Macrophage depletion induced by clodronate-loaded erythrocytes. | Journal of drug targeting 20050201 |
| [Effect of glucocorticoids on bone mineral density in patients with idiopathic thrombocytopenic purpura]. | [Rinsho ketsueki] The Japanese journal of clinical hematology 20050201 |
| Exploring the role of different drug transport routes in permeability screening. | Journal of medicinal chemistry 20050127 |
| [Diphosphonates in solid malignant tumors]. | Ugeskrift for laeger 20050124 |
| Sequence- and schedule-dependent enhancement of zoledronic acid induced apoptosis by doxorubicin in breast and prostate cancer cells. | International journal of cancer 20050120 |
| Rat model of the hypercalcaemia induced by parathyroid hormone-related protein: characteristics of three bisphosphonates. | European journal of pharmacology 20050110 |
| Effective parenteral clodronate treatment of a child with severe juvenile idiopathic osteoporosis. | European journal of pediatrics 20050101 |
| Kupffer cell depletion with liposomal clodronate prevents suppression of Ntcp expression in endotoxin-treated rats. | Journal of hepatology 20050101 |
| Depletion of alveolar macrophages by clodronate-liposomes aggravates ischemia-reperfusion injury of the lung. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20050101 |
| The role of Kupffer cells after major liver surgery. | JPEN. Journal of parenteral and enteral nutrition 20050101 |
| The role of bisphosphonates in the management of advanced cancer with a focus on non-small-cell lung cancer. Part 1: Mechanisms of action, role of biomarkers and preclinical applications. | Oncology 20050101 |
| [The effects of clodronate for the pain treatment of bone metastasis due to prostate cancer]. | Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology 20050101 |
| Macrophage depletion prevents anti-graft antibody production and results in long-term survival in xenotransplantation. | Transplantation proceedings 20050101 |
| Adjuvant clodronate in breast cancer. | Acta oncologica (Stockholm, Sweden) 20050101 |
| Alveolar macrophages regulate neutrophil recruitment in endotoxin-induced lung injury. | Respiratory research 20050101 |
| Lung inflammation induced by endotoxin is enhanced in rats depleted of alveolar macrophages with aerosolized clodronate. | Experimental lung research 20050101 |
| [Association between primary hyperparathyroidism and Paget's disease. Report of a case]. | Anales otorrinolaringologicos ibero-americanos 20050101 |
| Bisphosphonates and atherosclerosis: why? | Lupus 20050101 |
| Unilateral anterior uveitis complicating zoledronic acid therapy in breast cancer. | BMC cancer 20050101 |
| [Zoledronic acid and bone pathology in the course of neoplasia. Part I]. | Tumori 20050101 |
| Cost analysis of secondary prophylaxis with oral clodronate versus pamidronate in metastatic breast cancer patients. | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20041201 |
| Role of lung macrophages on susceptibility to respiratory infection following short-term moderate exercise training. | American journal of physiology. Regulatory, integrative and comparative physiology 20041201 |
| Depletion of intestinal resident macrophages prevents ischaemia reperfusion injury in gut. | Gut 20041201 |
| The role of bisphosphonates in breast cancer. | Breast (Edinburgh, Scotland) 20041201 |
| Steroid-free medium discloses oestrogenic effects of the bisphosphonate clodronate on breast cancer cells. | British journal of cancer 20041101 |
| [Synthesis of phosphonic acid and phosphinic acid derivatives for development of biologically active compounds]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20041101 |
| Enhanced engraftment of human cells in RAG2/gammac double-knockout mice after treatment with CL2MDP liposomes. | Experimental hematology 20041101 |
| Clodronate inhibits the secretion of proinflammatory cytokines and NO by isolated microglial cells and reduces the number of proliferating glial cells in excitotoxically injured organotypic hippocampal slice cultures. | Experimental neurology 20041001 |
| The use of a model of in vivo macrophage depletion to study the role of macrophages during infection with Bacillus anthracis spores. | Microbial pathogenesis 20041001 |
| Bisphosphonates in the treatment of skeletal metastases. | Seminars in oncology 20041001 |
| Profiling the safety and tolerability of bisphosphonates. | Seminars in oncology 20041001 |
| Patient management issues in metastatic bone disease. | Seminars in oncology 20041001 |
| Effects of local administration of clodronate on orthodontic tooth movement and root resorption in rats. | European journal of orthodontics 20041001 |
| Severe osteomyelitis of the jaw in long-term survivors of multiple myeloma: a new clinical entity. | The American journal of medicine 20040915 |
| Is there a role for chemotherapy in prostate cancer? | British journal of cancer 20040913 |
| Risedronate and pamidronate treatment in the clinical management of patients with severe Paget's disease of bone and acquired resistance to bisphosphonates. | Calcified tissue international 20040901 |
| Differential inhibition of invasion and proliferation by bisphosphonates: anti-metastatic potential of Zoledronic acid in prostate cancer. | European urology 20040901 |
| Short-term intermittent intravenous clodronate in the prevention of bone loss related to chemotherapy-induced ovarian failure. | Breast cancer research and treatment 20040901 |
| Toxicity and antineoplastic effect of (24R)-1,24-dihydroxyvitamin D3 (PRI-2191). | Steroids 20040901 |
| In vitro toxicity of bisphosphonates on human neuroblastoma cell lines. | Anti-cancer drugs 20040901 |
| Nitrogen-containing bisphosphonates inhibit cell cycle progression in human melanoma cells. | British journal of cancer 20040816 |
| Tamoxifen treatment reverses the adverse effects of chemotherapy-induced ovarian failure on serum lipids. | British journal of cancer 20040802 |
| Macrophages in spleen and liver direct the migration pattern of rat neutrophils during inflammation. | European journal of haematology 20040801 |
| Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis. | Osteoarthritis and cartilage 20040801 |
| Pneumolysin-induced lung injury is independent of leukocyte trafficking into the alveolar space. | Journal of immunology (Baltimore, Md. : 1950) 20040715 |
| Adoptive transfer of alveolar macrophages abrogates bronchial hyperresponsiveness. | American journal of respiratory cell and molecular biology 20040701 |
| Prevention and management of osteoporosis in women with breast cancer and men with prostate cancer. | Current oncology reports 20040701 |
| Tissue monocytes/macrophages in inflammation: hyperalgesia versus opioid-mediated peripheral antinociception. | Anesthesiology 20040701 |
| Systematic review of bisphosphonates for hypercalcaemia of malignancy. | Palliative medicine 20040701 |
| Innate inflammatory cells are not responsible for early death of donor myoblasts after myoblast transfer therapy. | Transplantation 20040627 |
| Macrophages play a role in the early phase of corneal allograft rejection in rats. | Transplantation 20040615 |
| Hypocalcaemia after intravenous bisphosphonate: adjuvant bisphosphonate is not currently accepted practice. | BMJ (Clinical research ed.) 20040612 |
| Minocycline delays photoreceptor death in the rds mouse through a microglia-independent mechanism. | Experimental eye research 20040601 |
| Role of macrophages in virus-induced airway hyperresponsiveness and neuronal M2 muscarinic receptor dysfunction. | American journal of physiology. Lung cellular and molecular physiology 20040601 |
| The role of bisphosphonates in breast and prostate cancers. | Endocrine-related cancer 20040601 |
| Kupffer cell-depleted rats have a diminished acute-phase response following major liver resection. | Shock (Augusta, Ga.) 20040601 |
| Role of macrophages in a mouse model of postoperative MRSA enteritis. | The Journal of surgical research 20040515 |
| Alveolar macrophages are a primary barrier to pulmonary absorption of macromolecules. | American journal of physiology. Lung cellular and molecular physiology 20040501 |
| Clodronate reduces vertebral fracture risk in women with postmenopausal or secondary osteoporosis: results of a double-blind, placebo-controlled 3-year study. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20040501 |
| Peripheral macrophage depletion reduces central nervous system parasitism and damage in Trypanosoma cruzi-infected suckling rats. | Journal of neuroimmunology 20040401 |
| Cytostatic and apoptotic effects of bisphosphonates on prostate cancer cells. | European urology 20040401 |
| VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment. | The Journal of clinical investigation 20040401 |
| Macrophage depletion reduces monocyte chemotactic protein-1 and transforming growth factor-beta1 in healing rat vein grafts. | Journal of vascular surgery 20040401 |
| Oral ibandronate reduces the risk of skeletal complications in breast cancer patients with metastatic bone disease: results from two randomised, placebo-controlled phase III studies. | British journal of cancer 20040322 |
| Efficient depletion of alveolar macrophages using intratracheally inhaled aerosols of liposome-encapsulated clodronate. | Experimental lung research 20040301 |
| Selective in vitro antioxidant properties of bisphosphonates. | Biochemical and biophysical research communications 20040213 |
| Effects of clodronate and alendronate on local and systemic changes in bone metabolism in rats with adjuvant arthritis. | Inflammation 20040201 |
| [Bisphosphonates in malignant hypercalcemia and bone pain]. | Revue medicale de la Suisse romande 20040201 |
| Determination of disodium clodronate in human plasma and urine using gas-chromatography-nitrogen-phosphorous detections: validation and application in pharmacokinetic study. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040105 |
| Effects of weekly administrations of alendronate+clodronate on young mouse tibia: localized action at the proximal growth plate. | Calcified tissue international 20040101 |
| Utilization of palliative radiotherapy for breast cancer patients with bone metastases treated with bisphosphonates-Toronto Sunnybrook Regional Cancer Centre experience. | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20040101 |
| Crucial role of synovial lining macrophages in the promotion of transforming growth factor beta-mediated osteophyte formation. | Arthritis and rheumatism 20040101 |
| A systematic review of the role of bisphosphonates in metastatic disease. | Health technology assessment (Winchester, England) 20040101 |
| Safety and convenience of a 15-minute infusion of zoledronic acid. | The oncologist 20040101 |
| Inflammatory cell recruitment following thoracic irradiation. | Experimental lung research 20040101 |
| 4th meeting of the EU research network EUROME: from the identification of genes and cellular networks in murine models of arthritis to novel therapeutic intervention strategies in rheumatoid arthritis, London, UK, 9 March 2004. | Arthritis research & therapy 20040101 |
| A tolerability and pharmacokinetic study of a new injectable formulation of disodium clodronate in healthy female volunteers. | European journal of drug metabolism and pharmacokinetics 20040101 |
| Antiresorption therapy and reduction in fracture susceptibility in the osteoporotic elderly patient: open study. | European review for medical and pharmacological sciences 20040101 |
| Effects of clodronate on cancer growth and Ca2+ signaling of human thyroid carcinoma cell lines. | Anticancer research 20040101 |
| Do physicians follow systemic treatment and funding policy guidelines? | The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique 20040101 |
| Bisphosphonates: clinical experience. | The oncologist 20040101 |
| Safety of intravenous and oral bisphosphonates and compliance with dosing regimens. | The oncologist 20040101 |
| Toward new horizons: the future of bisphosphonate therapy. | The oncologist 20040101 |
| Use of 18O3-clodronate as an internal standard for the quantitative analysis of clodronate in human plasma by gas chromatography/electron ionisation mass spectrometry. | Rapid communications in mass spectrometry : RCM 20040101 |
| Involvement of CD8+ T-cells in exacerbation of corneal scarring in mice. | Current eye research 20040101 |
| Use of bisphosphonates can dramatically improve pain in advanced hormone-refractory prostate cancer patients. | Prostate cancer and prostatic diseases 20040101 |
| Ten-year follow-up of a randomized controlled trial of adjuvant clodronate treatment in node-positive breast cancer patients. | Acta oncologica (Stockholm, Sweden) 20040101 |
| Clodronate : a review of its use in the prevention of bone metastases and the management of skeletal complications associated with bone metastases in patients with breast cancer. | Drugs & aging 20040101 |
| Macrophage derived signalling regulates negatively the megakaryocyte compartment. | Cellular and molecular biology (Noisy-le-Grand, France) 20040101 |
| [Expanding the possibilities of using biphosphonates for prophylaxis and treatment of osteal complications in malignant metastasis]. | Eksperimental'naia i klinicheskaia farmakologiia 20040101 |
| [AIOM Conference 2004. Endocrine therapy and management of patients with bone metastasis of breast cancer]. | Tumori 20040101 |
| Effects of macrophage depletion on peritoneal inflammation in swiss mice, edible frogs and goldfish. | Folia biologica 20040101 |
| Minor effect of depletion of resident macrophages from peritoneal cavity on resistance of common carp Cyprinus carpio to blood flagellates. | Diseases of aquatic organisms 20031203 |
| Bisphosphonates to prevent skeletal complications in men with metastatic prostate cancer. | The Journal of urology 20031201 |
| Levels and molecular forms of MMP-7 (matrilysin-1) and MMP-8 (collagenase-2) in diseased human peri-implant sulcular fluid. | Journal of periodontal research 20031201 |
| Bone resorption predicts for skeletal complications in metastatic bone disease. | British journal of cancer 20031201 |
| A single bisphosphonate infusion is associated with improved functional capacity in elderly subjects with primary hyperparathyroidism. | Aging clinical and experimental research 20031201 |
| Use of dichloromethylene bisphosphonate (Cl2MBP) to deplete macrophage function in the chicken. | British poultry science 20031201 |
| Systemic depletion of macrophages by liposomal bisphosphonates reduces neointimal formation following balloon-injury in the rat carotid artery. | Journal of cardiovascular pharmacology 20031101 |
| Differentiating the mechanisms of antiresorptive action of nitrogen containing bisphosphonates. | Bone 20031101 |
| Bisphosphonate therapy in the oncology setting. | Expert opinion on emerging drugs 20031101 |
| Oral clodronate therapy for hypercalcemia related to extensive subcutaneous fat necrosis in a newborn. | Journal of the Formosan Medical Association = Taiwan yi zhi 20031101 |
| Zoledronate sensitizes endothelial cells to tumor necrosis factor-induced programmed cell death: evidence for the suppression of sustained activation of focal adhesion kinase and protein kinase B/Akt. | The Journal of biological chemistry 20031031 |
| A new xenograft model for graft-versus-host disease by intravenous transfer of human peripheral blood mononuclear cells in RAG2-/- gammac-/- double-mutant mice. | Blood 20031001 |
| Medical treatment of vertebral osteoporosis. | European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 20031001 |
| Oral clodronate as treatment of osteogenesis imperfecta. | Archives of disease in childhood 20031001 |
| Do peritoneal macrophages play an essential role in the progression of acute pancreatitis in rats? | Pancreas 20031001 |
| The bisphosphonate pamidronate is a potent inhibitor of Ewing's sarcoma cell growth in vitro. | Anti-cancer drugs 20031001 |
| Long-term analgesic effect of clodronate in rodents. | Bone 20031001 |
| Effects of 4-year treatment with once-weekly clodronate on prevention of corticosteroid-induced bone loss and fractures in patients with arthritis: evaluation with dual-energy X-ray absorptiometry and quantitative ultrasound. | Bone 20031001 |
| Successful management of severe facial pain in patients with diffuse sclerosing osteomyelitis (DSO) of the mandible using disodium clodronate. | International journal of oral and maxillofacial surgery 20031001 |
| Efficacy of disodium-clodronate in the management of joint pain in rheumatoid arthritis. Six months open study. | Minerva medica 20031001 |
| Regulation of MMP-9 (gelatinase B) in activated human monocyte/macrophages by two different types of bisphosphonates. | Life sciences 20030926 |
| Role of macrophages in the generation of circulating blood nucleosomes from dead and dying cells. | Blood 20030915 |
| Clodronate stimulates osteoblast differentiation in ST2 and MC3T3-E1 cells and rat organ cultures. | European journal of pharmacology 20030905 |
| Bisphosphonates in prostate cancer: where are we and where should we go? | Journal of the National Cancer Institute 20030903 |
| Clinical trials test bisphosphonates in hormone-sensitive prostate cancer. | Journal of the National Cancer Institute 20030903 |
| A double-blind, placebo-controlled, randomized trial of oral sodium clodronate for metastatic prostate cancer (MRC PR05 Trial). | Journal of the National Cancer Institute 20030903 |
| Randomized, double-blind, controlled trial of mitoxantrone/prednisone and clodronate versus mitoxantrone/prednisone and placebo in patients with hormone-refractory prostate cancer and pain. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030901 |
| Safety of subcutaneous clodronate and efficacy in hypercalcemia of malignancy: a novel route of administration. | Journal of pain and symptom management 20030901 |
| Mechanism of action of bisphosphonates. | Current osteoporosis reports 20030901 |
| Effects of various absorption enhancers on transport of clodronate through Caco-2 cells. | International journal of pharmaceutics 20030811 |
| Expression of fractalkine in the rat testis: molecular cloning of a novel alternative transcript of its gene that is differentially regulated by pro-inflammatory cytokines. | Molecular human reproduction 20030801 |
| Macrophages of the splenic marginal zone are essential for trapping of blood-borne particulate antigen but dispensable for induction of specific T cell responses. | Journal of immunology (Baltimore, Md. : 1950) 20030801 |
| Macrophage depletion inhibits experimental choroidal neovascularization. | Investigative ophthalmology & visual science 20030801 |
| Macrophage depletion diminishes lesion size and severity in experimental choroidal neovascularization. | Investigative ophthalmology & visual science 20030801 |
| Bisphosphonate resistance in Paget's disease of bone. | Arthritis and rheumatism 20030801 |
| A combination of bisphosphonate and BMP additives in impacted bone allografts. | Acta orthopaedica Scandinavica 20030801 |
| Using of disodium clodronate on DSO patients. | International journal of oral and maxillofacial surgery 20030801 |
| Injectable bisphosphonates in the treatment of postmenopausal osteoporosis. | Aging clinical and experimental research 20030801 |
| Increased resistance of LFA-1-deficient mice to lipopolysaccharide-induced shock/liver injury in the presence of TNF-alpha and IL-12 is mediated by IL-10: a novel role for LFA-1 in the regulation of the proinflammatory and anti-inflammatory cytokine balance. | Journal of immunology (Baltimore, Md. : 1950) 20030715 |
| Bisphosphonates antagonise bone growth factors' effects on human breast cancer cells survival. | British journal of cancer 20030707 |
| Pharmacological characterization of the human P2Y13 receptor. | Molecular pharmacology 20030701 |
| Clinical evaluation of combined-modality therapy for bone metastasis of non-small-cell lung cancer. | Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20030701 |
| Inhibition of mevalonate pathway is involved in alendronate-induced cell growth inhibition, but not in cytokine secretion from macrophages in vitro. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20030701 |
| Prevention of acute lung injury in swine: depletion of pulmonary intravascular macrophages using liposomal clodronate. | The Journal of surgical research 20030601 |
| New insights into the actions of bisphosphonate zoledronic acid in breast cancer cells by dual RhoA-dependent and -independent effects. | British journal of cancer 20030519 |
| Macrophages restrict Pseudomonas aeruginosa growth, regulate polymorphonuclear neutrophil influx, and balance pro- and anti-inflammatory cytokines in BALB/c mice. | Journal of immunology (Baltimore, Md. : 1950) 20030515 |
| Macrophage depletion improves survival of porcine neonatal pancreatic cell clusters contained in alginate macrocapsules transplanted into rats. | Xenotransplantation 20030501 |
| Adhesion molecule expression in local-macrophage-depleted rats bearing orthotopic corneal allografts. | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20030501 |
| The bisphosphonate clodronate depletes microglial cells in excitotoxically injured organotypic hippocampal slice cultures. | Experimental neurology 20030501 |
| Cellular uptake and metabolism of clodronate and its derivatives in Caco-2 cells: a possible correlation with bisphosphonate-induced gastrointestinal side-effects. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20030501 |
| Aetiology of bone disease and the role of bisphosphonates in multiple myeloma. | The Lancet. Oncology 20030501 |
| Inhibition of matrix metalloproteinase-14 in osteosarcoma cells by clodronate. | The Journal of surgical research 20030501 |
| Clodronate in the management of breast cancer and multiple myeloma. | Ortopedia, traumatologia, rehabilitacja 20030430 |
| Clodronate induced uveitis. | Annals of the rheumatic diseases 20030401 |
| Zoledronic acid: an advance in tumour bone disease therapy and a new hope for osteoporosis. | Expert opinion on pharmacotherapy 20030401 |
| Macrophage depletion following liposomal-encapsulated clodronate (LIP-CLOD) injection enhances megakaryocytopoietic and thrombopoietic activities in mice. | British journal of haematology 20030401 |
| Determination of clodronate content in liposomal formulation by capillary zone electrophoresis. | Journal of pharmaceutical and biomedical analysis 20030401 |
| Intravenous treatment with liposome-encapsulated dichloromethylene bisphosphonate (Cl2MBP) suppresses nitric oxide production and reduces genetic resistance to Marek's disease. | Avian pathology : journal of the W.V.P.A 20030401 |
| Therapeutic factor VIII levels and negligible toxicity in mouse and dog models of hemophilia A following gene therapy with high-capacity adenoviral vectors. | Blood 20030301 |
| T cell-activated macrophages are capable of both recognition and rejection of pancreatic islet xenografts. | Journal of immunology (Baltimore, Md. : 1950) 20030301 |
| Long-term administration of clodronate does not prevent fracture healing in rats. | Clinical orthopaedics and related research 20030301 |
| [A patient with gastric cancer complicated with severe DIC and multiple bone metastasis showing a high response to combination of TS-1 and CDDP]. | Gan to kagaku ryoho. Cancer & chemotherapy 20030301 |
| Biodegradable microspheres targeting mucosal immune-regulating cells: new approach for treatment of inflammatory bowel disease. | Journal of gastroenterology 20030301 |
| Clodronate stimulates bone formation as well as inhibits bone resorption and increases bone mineral density in rats fed a low-calcium diet. | Journal of medical and dental sciences 20030301 |
| Parenteral nutrition. | Current opinion in gastroenterology 20030301 |
| Clodronate treatment of established bone loss in cardiac recipients: a randomized study. | Transplantation 20030215 |
| Mechanisms of osteolytic bone metastases in breast carcinoma. | Cancer 20030201 |
| Antitumor effects of bisphosphonates. | Cancer 20030201 |
| Effectiveness and cost of bisphosphonate therapy in tumor bone disease. | Cancer 20030201 |
| Current and future status of adjuvant therapy for breast cancer. | Cancer 20030201 |
| Antagonistic effects of different classes of bisphosphonates in osteoclasts and macrophages in vitro. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20030201 |
| Elimination of local macrophages in intestine prevents chronic colitis in interleukin-10-deficient mice. | Digestive diseases and sciences 20030201 |
| Effect of local macrophage depletion on cellular immunity and tolerance evoked by corneal allografts. | Current eye research 20030201 |
| [Effects of bisphosphonate on the inflammation]. | Clinical calcium 20030201 |
| Liposomal clodronate as a novel agent for treating autoimmune hemolytic anemia in a mouse model. | Blood 20030115 |
| Alveolar macrophages have a protective antiinflammatory role during murine pneumococcal pneumonia. | American journal of respiratory and critical care medicine 20030115 |
| Prevention of bone metastases from breast cancer by adjuvant bisphosphonate therapy. | Breast cancer (Tokyo, Japan) 20030101 |
| Selective depletion or blockade of Kupffer cells leads to enhanced and prolonged hepatic transgene expression using high-capacity adenoviral vectors. | Molecular therapy : the journal of the American Society of Gene Therapy 20030101 |
| Characterization of an in vitro model of calcification in retinal pigmented epithelial cells. | Journal of atherosclerosis and thrombosis 20030101 |
| The diagnosis and management of hypercalcaemia. | Annals of the Academy of Medicine, Singapore 20030101 |
| Severe transient osteoporosis of the hip during pregnancy. Successful treatment with intravenous biphosphonates. | Clinical and experimental rheumatology 20030101 |
| Drugs in development: bisphosphonates and metalloproteinase inhibitors. | Arthritis research & therapy 20030101 |
| Biochemical markers of bone turnover, serum levels of interleukin-6/interleukin-6 soluble receptor and bisphosphonate treatment in Erdheim-Chester disease. | Clinical and experimental rheumatology 20030101 |
| Extended safety profile of oral clodronate after long-term use in primary breast cancer patients. | Drug safety 20030101 |
| Effect of elimination of donor Kupffer cells and/or recipient macrophages on acute rejection in liver transplantation. | Hepato-gastroenterology 20030101 |
| [The use of parenteral clodronate in elderly women with postmenopausal osteoporosis: compliance, effects on bone mineral density and on bone turnover]. | Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna 20030101 |
| Bisphosphonates in oncology: physiopathologic bases and clinical activity. | Tumori 20030101 |
| Mactinin: a modulator of the monocyte response to inflammation. | Arthritis research & therapy 20030101 |
| Effect of raloxifene and clodronate on bone density in postmenopausal osteoporotic women. | International journal of tissue reactions 20030101 |
| New insights into the molecular mechanisms of action of bisphosphonates. | Current pharmaceutical design 20030101 |
| Should all adjuvant breast cancer patients receive a bisphosphonate? | Breast cancer research : BCR 20030101 |
| Quantitative ultrasound of bone and clodronate effects in thalassemia-induced osteoporosis. | Journal of bone and mineral metabolism 20030101 |
| [Prognostication of hematotoxicity for radio- and chemotherapy in patients with breast cancer]. | Voprosy onkologii 20030101 |
| Clodronate as a single-dose intravenous infusion effectively provides short-term correction of malignant hypercalcemia. | Acta oncologica (Stockholm, Sweden) 20030101 |
| 'In vivo' depletion of macrophages by liposome-mediated 'suicide'. | Methods in enzymology 20030101 |
| [Efficacy and feasibility evaluation in long term pamidronate treatment of bone metastases]. | Przeglad lekarski 20030101 |
| Clodronate for treatment of bone metastases in hormone refractory prostate cancer. | International braz j urol : official journal of the Brazilian Society of Urology 20030101 |
| Current management strategies for hypercalcemia. | Treatments in endocrinology 20030101 |
| APCs in the liver and spleen recruit activated allogeneic CD8+ T cells to elicit hepatic graft-versus-host disease. | Journal of immunology (Baltimore, Md. : 1950) 20021215 |
| Prevention of bone loss by clodronate in early postmenopausal women with vertebral osteopenia: a dose-finding study. | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20021201 |
| Disease modifying and anti-nociceptive effects of the bisphosphonate, zoledronic acid in a model of bone cancer pain. | Pain 20021201 |
| The anti-tumour activity of bisphosphonates. | Cancer treatment reviews 20021201 |
| Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice. | Chemical research in toxicology 20021201 |
| Efficacy of bisphosphonates in the management of skeletal complications of bone metastases and selection of clinical endpoints. | American journal of clinical oncology 20021201 |
| Future directions in the treatment and prevention of bone metastases. | American journal of clinical oncology 20021201 |
| Treatment of hypercalcemia of malignancy with bisphosphonates. | Seminars in oncology 20021201 |
| Bisphosphonates for the prevention of bone metastases. | Seminars in oncology 20021201 |
| [Therapy for hormone-refractory prostate cancer]. | Nihon rinsho. Japanese journal of clinical medicine 20021201 |
| Bisphosphonates inhibit angiogenesis in vitro and testosterone-stimulated vascular regrowth in the ventral prostate in castrated rats. | Cancer research 20021115 |
| Bisphosphonates as adjuvant treatment for breast cancer. | BMJ (Clinical research ed.) 20021109 |
| Clodronate: mechanisms of action on bone remodelling and clinical use in osteometabolic disorders. | Expert opinion on pharmacotherapy 20021101 |
| Intestinal drug delivery systems with biodegradable microspheres targeting mucosal immune-regulating cells for chronic inflammatory colitis. | Journal of gastroenterology 20021101 |
| [A questionnaire survey of tolerance and adverse effects of clodronate (Bonefos) in patients with multiple myeloma]. | Vnitrni lekarstvi 20021101 |
| [⁸⁹SrCl₂ and/or Bonefos in the treatment of bone metastasis from pulmonary carcinoma]. | Zhongguo fei ai za zhi = Chinese journal of lung cancer 20021020 |
| Effect of bisphosphonates on viability, proliferation, and dexamethasone-induced apoptosis of articular chondrocytes. | Annals of the rheumatic diseases 20021001 |
| Bisphosphonates for RSDS and prostate cancer--more benefit then revealed! | Joint, bone, spine : revue du rhumatisme 20021001 |
| Suppression of viability and acetyl-LDL metabolism in RAW 264 macrophage-like and smooth muscle cells by bisphosphonates in vitro. | Methods and findings in experimental and clinical pharmacology 20021001 |
| The interactions of bisphosphonates in solution and as coatings on hydroxyapatite with osteoblasts. | Journal of materials science. Materials in medicine 20021001 |
| American Society of Clinical Oncology clinical practice guidelines: the role of bisphosphonates in multiple myeloma. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020901 |
| Clodronate inhibits adrenocortical cell proliferation and P450c21 activity. | The Journal of endocrinology 20020901 |
| The absolute bioavailability of clodronate from two different oral doses. | Bone 20020901 |
| Bisphosphonates and tumor burden. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020801 |
| Randomized, placebo-controlled trial of clodronate in patients with primary operable breast cancer. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020801 |
| Bisphosphonates in the treatment of thalassemia-induced osteoporosis. | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20020801 |
| Bisphosphonates: biological response modifiers in breast cancer. | Clinical breast cancer 20020801 |
| Macrophage depletion by clodronate-containing liposomes reduces neointimal formation after balloon injury in rats and rabbits. | Circulation 20020730 |
| The bisphosphonate pamidronate induces apoptosis in human melanoma cells in vitro. | British journal of cancer 20020729 |
| The difluoromethylenesulfonic acid group as a monoanionic phosphate surrogate for obtaining PTP1B inhibitors. | Bioorganic & medicinal chemistry 20020701 |
| Bisphosphonates for cancer patients: why, how, and when? | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20020701 |
| Skeletal deposition of clodronate is related to parathyroid function and bone turnover in dialysis patients. | Clinical nephrology 20020701 |
| Role of resident alveolar macrophages in leukocyte traffic into the alveolar air space of intact mice. | American journal of physiology. Lung cellular and molecular physiology 20020601 |
| Bisphosphonate prodrugs. | Current medicinal chemistry 20020601 |
| Dissociation of angiogenesis and osteoclastogenesis during endochondral bone formation in neonatal mice. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20020601 |
| Bisphosphonates influence the proliferation and the maturation of normal human osteoblasts. | Journal of endocrinological investigation 20020601 |
| Novel approaches to the management of bone metastases in patients with breast cancer. | Seminars in oncology 20020601 |
| Correction of the nonlinear dose response improves the viability of adenoviral vectors for gene therapy of Fabry disease. | Human gene therapy 20020520 |
| The bisphosphonate zoledronic acid impairs Ras membrane [correction of impairs membrane] localisation and induces cytochrome c release in breast cancer cells. | British journal of cancer 20020506 |
| Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite. | Molecular pharmacology 20020501 |
| Macrophages are necessary for maximal nuclear factor-kappa B activation in response to endotoxin. | American journal of respiratory cell and molecular biology 20020501 |
| Alendronate inhibits invasion of PC-3 prostate cancer cells by affecting the mevalonate pathway. | Cancer research 20020501 |
| Effects of topical administration of clodronate on alveolar bone resorption in rats with experimental periodontitis. | Journal of periodontology 20020501 |
| Complete healing of severe osteoradionecrosis with treatment combining pentoxifylline, tocopherol and clodronate. | The British journal of radiology 20020501 |
| [Bisphosphonates and adhesion molecules]. | Clinical calcium 20020501 |
| Is there a dose response relationship for clodronate in the treatment of tumour induced hypercalcaemia? | British journal of cancer 20020422 |
| [Macrophage depletion inhibits leukocyte recruitment in experimental melanin-induced uveitis (EMIU)]. | Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 20020401 |
| [Is pamidronate or clodronate better?]. | Vnitrni lekarstvi 20020401 |
| [Bisphosphonate therapy in Paget disease?]. | Deutsche medizinische Wochenschrift (1946) 20020322 |
| Reductions in bone mass, structure, and strength in axial and appendicular skeletons associated with increased turnover after ovariectomy in mature cynomolgus monkeys and preventive effects of clodronate. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20020301 |
| Disodium chlodronate prevents bone resorption in experimental periodontitis in rats. | Journal of periodontology 20020301 |
| Bisphosphonates inhibit stromelysin-1 (MMP-3), matrix metalloelastase (MMP-12), collagenase-3 (MMP-13) and enamelysin (MMP-20), but not urokinase-type plasminogen activator, and diminish invasion and migration of human malignant and endothelial cell lines. | Anti-cancer drugs 20020301 |
| Suppression of immunoreactive macrophages in atheromatous lesions of rabbits by clodronate. | Pharmacology & toxicology 20020301 |
| Involvement of macrophages in the pathogenesis of transmissible spongiform encephalopathies. | Developmental immunology 20020301 |
| Prospective evaluation of the peptide-bound collagen type I cross-links N-telopeptide and C-telopeptide in predicting bone metastases status. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020201 |
| Rapid recovery of platelet count following administration of liposome-encapsulated clodronate in a mouse model of immune thrombocytopenia. | British journal of haematology 20020201 |
| Electrospray ionization mass spectrometry and tandem mass spectrometry of clodronate and related bisphosphonate and phosphonate compounds. | Journal of mass spectrometry : JMS 20020201 |
| Clodronate in myelofibrosis: a case report. | The American journal of the medical sciences 20020201 |
| Bisphosphonate space measurement and dosage requirement for intravenous clodronate treatment of Paget's disease. | Calcified tissue international 20020201 |
| The role of perivascular and meningeal macrophages in experimental allergic encephalomyelitis. | Journal of neuroimmunology 20020101 |
| Does postmenopausal hormone replacement therapy affect cardiac autonomic regulation in osteoporotic women? | Menopause (New York, N.Y.) 20020101 |
| Bisphosphonates suppress bone resorption by a direct effect on early osteoclast precursors without affecting the osteoclastogenic capacity of osteogenic cells: the role of protein geranylgeranylation in the action of nitrogen-containing bisphosphonates on osteoclast precursors. | Bone 20020101 |
| Bisphosphonates for breast cancer. | The Cochrane database of systematic reviews 20020101 |
| Direct effects of bisphosphonates on breast cancer cells. | Breast cancer research : BCR 20020101 |
| The present and future role of bisphosphonates in the management of patients with breast cancer. | Breast cancer research : BCR 20020101 |
| Development of bisphosphonates. | Breast cancer research : BCR 20020101 |
| Actions of bisphosphonates in animal models of breast cancer. | Breast cancer research : BCR 20020101 |
| Treatment of complex regional pain syndrome type I. | European journal of pain (London, England) 20020101 |
| Reduction of instability-induced bone resorption using bisphosphonates: high doses are needed in rats. | Acta orthopaedica Scandinavica 20020101 |
| Recent advances in breast cancer (the Twenty-fourth San Antonio Breast Cancer Symposium, December, 2001). | Current medical research and opinion 20020101 |
| Bisphosphonates for the relief of pain secondary to bone metastases. | The Cochrane database of systematic reviews 20020101 |
| Food-drug interactions. | Drugs 20020101 |
| Liposomes--an invaluable tool in bisphosphonate research. | Cellular & molecular biology letters 20020101 |
| Clodronate treatment reduces serum levels of interleukin-6 soluble receptor in Paget's disease of bone. | Clinical and experimental rheumatology 20020101 |
| Microstructural properties of bone in rat vertebra after long-term clodronate treatment. | Journal of bone and mineral metabolism 20020101 |
| Bisphosphonates in multiple myeloma. | The Cochrane database of systematic reviews 20020101 |
| Changes in size of periarthritis calcifications in patients with painful shoulder treated with injectable disodium-clodronate. | International journal of clinical pharmacology research 20020101 |
| Bisphosphonate therapy in multiple myeloma: past, present, future. | European journal of haematology 20020101 |
| Macrophage-dependent regulation of neutrophil mobilization and chemotaxis during development of sterile peritonitis in the rat. | European journal of haematology 20020101 |
| [The role of adjuvant clodronate therapy for prevention of bone metastasis in breast cancer]. | Magyar onkologia 20020101 |
| Effects of Cl2MDP-encapsulating liposomes in a murine model of Pseudomonas aeruginosa-induced sepsis. | Journal of liposome research 20020101 |
| Clodronate liposomes: perspectives in research and therapeutics. | Journal of liposome research 20020101 |
| Search of antimicrobial activity of selected non-antibiotic drugs. | Acta poloniae pharmaceutica 20020101 |
| Long-term impact of chemotherapy-induced ovarian failure on bone mineral density (BMD) in premenopausal breast cancer patients. The effect of adjuvant clodronate treatment. | European journal of cancer (Oxford, England : 1990) 20011201 |
| Inhibition of bone resorption by alendronate and risedronate does not require osteoclast apoptosis. | Bone 20011201 |
| Novel therapeutic approaches to cancer patients with bone metastasis. | Critical reviews in oncology/hematology 20011201 |
| [Parenteral disodium-clodronate in patients with rheumatoid arthritis. A two-month open clinical study]. | Minerva medica 20011201 |
| Effects of long-term administration of clodronate on growing rat bone. | Calcified tissue international 20011201 |
| Clinical and biochemical response to single infusion of clodronate in active rheumatoid arthritis--a double blind placebo controlled study. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20011201 |
| Suppression of T cells results in long-term survival of mouse heart xenografts in C6-deficient rats. | Xenotransplantation 20011101 |
| The cellular uptake and metabolism of clodronate in RAW 264 macrophages. | Pharmaceutical research 20011101 |
| Meningeal and perivascular macrophages of the central nervous system play a protective role during bacterial meningitis. | Journal of immunology (Baltimore, Md. : 1950) 20011015 |
| Critical role of Kupffer cell-derived IL-10 for host defense in septic peritonitis. | Journal of immunology (Baltimore, Md. : 1950) 20011001 |
| Nitrogen-containing bisphosphonates induce apoptosis of Caco-2 cells in vitro by inhibiting the mevalonate pathway: a model of bisphosphonate-induced gastrointestinal toxicity. | Bone 20011001 |
| Paget's disease of the spine and its management. | European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 20011001 |
| Comparison of the effects of intravenous pamidronate and oral clodronate on symptoms and bone resorption in patients with metastatic bone disease. | Annals of oncology : official journal of the European Society for Medical Oncology 20011001 |
| Bisphosphonates in the treatment of metastatic breast cancer. | Journal of mammary gland biology and neoplasia 20011001 |
| Macrophage depletion impairs oligodendrocyte remyelination following lysolecithin-induced demyelination. | Glia 20010901 |
| Suppression of chronic streptococcal cell wall-induced arthritis in Lewis rats by liposomal clodronate. | Rheumatology (Oxford, England) 20010901 |
| The molecular mechanism of action of the antiresorptive and antiinflammatory drug clodronate: evidence for the formation in vivo of a metabolite that inhibits bone resorption and causes osteoclast and macrophage apoptosis. | Arthritis and rheumatism 20010901 |
| Long-term release of clodronate from biodegradable microspheres. | AAPS PharmSciTech 20010901 |
| Effects of low-dose, noncytotoxic, intraarticular liposomal clodronate on development of erosions and proteoglycan loss in established antigen-induced arthritis in rabbits. | Arthritis and rheumatism 20010801 |
| Disodium clodronate in the treatment of diffuse sclerosing osteomyelitis (DSO) of the mandible. | International journal of oral and maxillofacial surgery 20010801 |
| A combination of a chemically modified doxycycline and a bisphosphonate synergistically inhibits endotoxin-induced periodontal breakdown in rats. | Journal of periodontology 20010801 |
| [Use of clodronic acid in mineral metabolism conditions: state of the art in 2000]. | Minerva medica 20010801 |
| Dosing regimens and main adverse events of bisphosphonates. | Seminars in oncology 20010801 |
| Bisphosphonates in the prevention of bone metastases: current evidence. | Seminars in oncology 20010801 |
| Adjuvant bisphosphonate therapy: the future. | Seminars in oncology 20010801 |
| [Bisphosphonates in the treatment of breast carcinoma]. | Polskie Archiwum Medycyny Wewnetrznej 20010801 |
| Bisphosphonates may be useful in treatment of bone metastases. | Journal of the National Cancer Institute 20010718 |
| Macrophage depletion prevents leukocyte adhesion and disease induction in experimental melanin-protein induced uveitis. | Experimental eye research 20010701 |
| [Double-blinded controlled study comparing clodronate versus placebo in patients with breast cancer bone metastases]. | Bulletin du cancer 20010701 |
| Thromboxane mediates pulmonary hypertension and lung inflammation during hyperacute lung rejection. | Journal of applied physiology (Bethesda, Md. : 1985) 20010601 |
| Kupffer cells and neutrophils as paracrine regulators of the heme oxygenase-1 gene in hepatocytes after hemorrhagic shock. | Shock (Augusta, Ga.) 20010601 |
| The bisphosphonate pamidronate is a potent inhibitor of human osteosarcoma cell growth in vitro. | Anti-cancer drugs 20010601 |
| A method for the selective depletion of perivascular and meningeal macrophages in the central nervous system. | Journal of neuroimmunology 20010601 |
| Long-term follow-up of a prospective, double-blind, placebo-controlled randomized trial of clodronate in multiple myeloma. | British journal of haematology 20010601 |
| Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro. | Bone 20010501 |
| Induction of proliferation and augmented cytotoxicity of gammadelta T lymphocytes by bisphosphonate clodronate. | Blood 20010501 |
| Atypical familial Paget's disease of bone. | Joint, bone, spine : revue du rhumatisme 20010501 |
| CD8+ phagocytes in focal ischemia of the rat brain: predominant origin from hematogenous macrophages and targeting to areas of pannecrosis. | Acta neuropathologica 20010501 |
| Expression of Th2 cytokines decreases the development of and improves Behçet's disease-like symptoms induced by herpes simplex virus in mice. | The Journal of infectious diseases 20010415 |
| Depletion of alveolar macrophages exerts protective effects in pulmonary tuberculosis in mice. | Journal of immunology (Baltimore, Md. : 1950) 20010401 |
| Analgesic effect of bisphosphonates in mice. | Pain 20010401 |
| Bisphosphonates regulate cell growth and gene expression in the UMR 106-01 clonal rat osteosarcoma cell line. | British journal of cancer 20010401 |
| Alveolar macrophages, surfactant lipids, and surfactant protein B regulate the induction of immune responses via the airways. | American journal of respiratory cell and molecular biology 20010401 |
| The effect of clodronate and antioestrogens on bone loss associated with oestrogen withdrawal in postmenopausal women with breast cancer. | British journal of cancer 20010401 |
| Consensus statement on the modern therapy of Paget's disease of bone from a Western Osteoporosis Alliance symposium. Biannual Foothills Meeting on Osteoporosis, Calgary, Alberta, Canada, September 9-10, 2000. | Clinical therapeutics 20010401 |
| Changes in murine bone marrow macrophages and erythroid burst-forming cells following the intravenous injection of liposome-encapsulated dichloromethylene diphosphonate (Cl2MDP). | European journal of haematology 20010401 |
| Bone marrow transplant conditioning intensified with liposomal clodronate to eliminate residual host antigen presenting cells fails to ameliorate GVHD and increases PERI-BMT mortality. | Transplantation 20010315 |
| Incidence and severity of herpetic stromal keratitis: impaired by the depletion of lymph node macrophages. | Experimental eye research 20010301 |
| A mouse model for postoperative fatal enteritis due to Staphylococcus infection. | The Journal of surgical research 20010301 |
| Effects of clodronate on vertebral fracture risk in osteoporosis: a 1-year interim analysis. | Bone 20010301 |
| An immunomodulatory procedure that stabilizes transgene expression and permits readministration of E1-deleted adenovirus vectors. | Molecular therapy : the journal of the American Society of Gene Therapy 20010301 |
| Central monoamine and plasma corticosterone changes induced by a bacterial endotoxin: sensitization and cross-sensitization effects. | The European journal of neuroscience 20010301 |
| Use of bisphosphonates for the treatment of metastatic bone pain. A survey of palliative physicians in the UK. | Palliative medicine 20010301 |
| Depletion of systemic macrophages by liposome-encapsulated clodronate attenuates striatal macrophage invasion and neurodegeneration following local endotoxin infusion in gerbils. | Brain research 20010216 |
| Th type 1-stimulating activity of lung macrophages inhibits Th2-mediated allergic airway inflammation by an IFN-gamma-dependent mechanism. | Journal of immunology (Baltimore, Md. : 1950) 20010201 |
| Effects of calcium and lipophilicity on transport of clodronate and its esters through Caco-2 cells. | International journal of pharmaceutics 20010201 |
| A combination of subtherapeutic doses of chemically modified doxycycline (CMT-8) and a bisphosphonate (clodronate) inhibits bone loss in the ovariectomized rat: a dynamic histomorphometric and gene expression study. | Current medicinal chemistry 20010201 |
| Overexpression of active TGF-beta-1 in the murine knee joint: evidence for synovial-layer-dependent chondro-osteophyte formation. | Osteoarthritis and cartilage 20010201 |
| Treatment of osteoporosis with bisphosphonates. | Rheumatic diseases clinics of North America 20010201 |
| The use of bisphosphonate for the palliative treatment of painful bone metastasis due to hormone refractory prostate cancer. | The Journal of urology 20010101 |
| Adjuvant clodronate treatment does not reduce the frequency of skeletal metastases in node-positive breast cancer patients: 5-year results of a randomized controlled trial. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010101 |
| Alterations in osteoclast morphology following long-term 17beta-estradiol administration in the mouse. | BMC cell biology 20010101 |
| Bone mineral density in multiple myeloma patients after intravenous clodronate therapy. | Acta medica Austriaca 20010101 |
| One-month follow-up of patients treated by intravenous clodronate for acute pain induced by osteoporotic vertebral fracture. | Drugs under experimental and clinical research 20010101 |
| Effect of intramuscular clodronate on bone mass and metabolism in osteoporotic women. | International journal of tissue reactions 20010101 |
| Bone loss. Therapeutic approaches for preventing bone loss in inflammatory arthritis. | Arthritis research 20010101 |
| Reduction of visible bone metastases by clodronate therapy in breast cancer. | European journal of gynaecological oncology 20010101 |
| Bisphosphonates in multiple myeloma. | The Cochrane database of systematic reviews 20010101 |
| Strategies for management of prostate cancer-related bone pain. | Drugs & aging 20010101 |
| [Use of clodronate in the adjuvant treatment of breast cancer is questionable for the time being]. | Duodecim; laaketieteellinen aikakauskirja 20010101 |
| Bisphosphonates induce breast cancer cell death in vitro. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20001101 |
| Bisphosphonates induce apoptosis in human breast cancer cell lines. | British journal of cancer 20000401 |
| Endotoxin-induced aggravation of preservation-reperfusion injury of rat liver and its modulation. | Journal of hepatology 20000101 |
| Calcitriol-mediated hypercalcaemia and increased interleukins in a patient with sarcoid myopathy. | Clinical rheumatology 19990101 |
| Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 19980401 |
| An in vitro and in vivo study of cytokines in the acute-phase response associated with bisphosphonates. | Calcified tissue international 19971101 |
| Cauda equina syndrome with pagetic vertebral fusion. Clinical recovery under calcium-vitamin D supplementation plus clodronate after apparent failure of pamidronate and acquired resistance to etidronate. | Revue du rhumatisme (English ed.) 19970101 |
| Characteristics of clodronate-induced apoptosis in osteoclasts and macrophages. | Molecular pharmacology 19961101 |
| Clodronate therapy of metastatic bone disease in patients with prostatic carcinoma. | Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 19890101 |
| PPi analogs as inhibitors of human T-lymphotropic virus type III reverse transcriptase. | Antimicrobial agents and chemotherapy 19860501 |
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