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Home > Indoles and Oxindole > 105431-72-9
105431-72-9 | 1-phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one
CAS No: 105431-72-9 Catalog No: AG007ENV MDL No:MFCD00867216
Product Description
Catalog Number:
AG007ENV
Chemical Name:
1-phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one
CAS Number:
105431-72-9
Molecular Formula:
C26H21N3O
Molecular Weight:
391.4644
MDL Number:
MFCD00867216
IUPAC Name:
1-phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one
InChI:
InChI=1S/C26H21N3O/c30-25-26(18-20-10-14-27-15-11-20,19-21-12-16-28-17-13-21)23-8-4-5-9-24(23)29(25)22-6-2-1-3-7-22/h1-17H,18-19H2
InChI Key:
YEJCDKJIEMIWRQ-UHFFFAOYSA-N
SMILES:
O=C1N(c2ccccc2)c2c(C1(Cc1ccncc1)Cc1ccncc1)cccc2
UNII:
I5TB3NZ94T
Properties
Complexity:
555
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
391.168g/mol
Formal Charge:
0
Heavy Atom Count:
30
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
391.474g/mol
Monoisotopic Mass:
391.168g/mol
Rotatable Bond Count:
5
Topological Polar Surface Area:
46.1A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.1
Literature
| Title | Journal |
|---|---|
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| Muscarinic acetylcholine receptor-mediated effects in slices from human epileptogenic cortex. | Neuroscience 20121025 |
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| Pharmacological dissection of K(v)7.1 channels in systemic and pulmonary arteries. | British journal of pharmacology 20120601 |
| Reduced KCNQ4-encoded voltage-dependent potassium channel activity underlies impaired β-adrenoceptor-mediated relaxation of renal arteries in hypertension. | Hypertension (Dallas, Tex. : 1979) 20120401 |
| Effects of KCNQ channel modulators on the M-type potassium current in primate retinal pigment epithelium. | American journal of physiology. Cell physiology 20120301 |
| Heterogeneous firing behavior during ictal-like epileptiform activity in vitro. | Journal of neurophysiology 20120301 |
| Expression and function of KCNQ channels in larval zebrafish. | Developmental neurobiology 20120201 |
| Cholinergic modulation of the CAN current may adjust neural dynamics for active memory maintenance, spatial navigation and time-compressed replay. | Frontiers in neural circuits 20120101 |
| The Effects of the KCNQ Openers Retigabine and Flupirtine on Myotonia in Mammalian Skeletal Muscle Induced by a Chloride Channel Blocker. | Evidence-based complementary and alternative medicine : eCAM 20120101 |
| Distinct muscarinic acetylcholine receptor subtypes mediate pre- and postsynaptic effects in rat neocortex. | BMC neuroscience 20120101 |
| Functional significance of M-type potassium channels in nociceptive cutaneous sensory endings. | Frontiers in molecular neuroscience 20120101 |
| Inhibition of ion channels and heart beat in Drosophila by selective COX-2 inhibitor SC-791. | PloS one 20120101 |
| Evidence for inhibitory effects of flupirtine, a centrally acting analgesic, on delayed rectifier k(+) currents in motor neuron-like cells. | Evidence-based complementary and alternative medicine : eCAM 20120101 |
| Contributions of Kv7-mediated potassium current to sub- and suprathreshold responses of rat layer II/III neocortical pyramidal neurons. | Journal of neurophysiology 20111001 |
| KV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus. | Pharmacological research 20111001 |
| An in vitro model for testing drugs to treat tinnitus. | European journal of pharmacology 20110930 |
| Swelling-activated potassium channel in porcine pigmented ciliary epithelial cells. | Investigative ophthalmology & visual science 20110729 |
| KCNQ5 channels control resting properties and release probability of a synapse. | Nature neuroscience 20110701 |
| Potential role of KCNQ/M-channels in regulating neuronal differentiation in mouse hippocampal and embryonic stem cell-derived neuronal cultures. | Experimental neurology 20110601 |
| Reduction of an afterhyperpolarization current increases excitability in striatal cholinergic interneurons in rat parkinsonism. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20110427 |
| Eps8 regulates hair bundle length and functional maturation of mammalian auditory hair cells. | PLoS biology 20110401 |
| Involvement of inward rectifier and M-type currents in carbachol-induced epileptiform synchronization. | Neuropharmacology 20110301 |
| Expression and function of the K+ channel KCNQ genes in human arteries. | British journal of pharmacology 20110101 |
| K(V)7/KCNQ channels are functionally expressed in oligodendrocyte progenitor cells. | PloS one 20110101 |
| Drosophila KCNQ channel displays evolutionarily conserved electrophysiology and pharmacology with mammalian KCNQ channels. | PloS one 20110101 |
| Visceral hyperalgesia induced by forebrain-specific suppression of native Kv7/KCNQ/M-current in mice. | Molecular pain 20110101 |
| Participation of KCNQ (Kv7) potassium channels in myogenic control of cerebral arterial diameter. | The Journal of physiology 20100901 |
| Reactive oxygen species alters the electrophysiological properties and raises [Ca2+]i in intracardiac ganglion neurons. | American journal of physiology. Regulatory, integrative and comparative physiology 20100701 |
| Protein Phosphatase 2a and glycogen synthase kinase 3 signaling modulate prepulse inhibition of the acoustic startle response by altering cortical M-Type potassium channel activity. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100630 |
| Effect of salicylate on KCNQ4 of the guinea pig outer hair cell. | Journal of neurophysiology 20100401 |
| Cell-based potassium ion channel screening using the FluxOR assay. | Journal of biomolecular screening 20100401 |
| Property of I(K,)(n) in inner hair cells isolated from guinea-pig cochlea. | Hearing research 20100301 |
| Neuropharmacology of vestibular system disorders. | Current neuropharmacology 20100301 |
| Channelrhodopsin-2 localised to the axon initial segment. | PloS one 20100101 |
| The mechanism of abrupt transition between theta and hyper-excitable spiking activity in medial entorhinal cortex layer II stellate cells. | PloS one 20100101 |
| BK channels mediate cholinergic inhibition of high frequency cochlear hair cells. | PloS one 20100101 |
| The M-channel blocker linopirdine is an agonist of the capsaicin receptor TRPV1. | Journal of pharmacological sciences 20100101 |
| Kv7/KCNQ channels control action potential phasing of pyramidal neurons during hippocampal gamma oscillations in vitro. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20091021 |
| Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
| Functional study of the effect of phosphatase inhibitors on KCNQ4 channels expressed in Xenopus oocytes. | Acta pharmacologica Sinica 20090901 |
| Treatment with the Kv7 potassium channel activator flupirtine is beneficial in two independent mouse models of pulmonary hypertension. | British journal of pharmacology 20090801 |
| Molecular and functional characterization of Kv7 K+ channel in murine gastrointestinal smooth muscles. | American journal of physiology. Gastrointestinal and liver physiology 20090701 |
| KCNQ currents and their contribution to resting membrane potential and the excitability of interstitial cells of Cajal from the guinea pig bladder. | The Journal of urology 20090701 |
| An osmosensitive voltage-gated K+ current in rat supraoptic neurons. | The European journal of neuroscience 20090601 |
| KCNQ modulators reveal a key role for KCNQ potassium channels in regulating the tone of rat pulmonary artery smooth muscle. | The Journal of pharmacology and experimental therapeutics 20090401 |
| Neural KCNQ (Kv7) channels. | British journal of pharmacology 20090401 |
| The muscarinic inhibition of the potassium M-current modulates the action-potential discharge in the vestibular primary-afferent neurons of the rat. | Neuroscience 20090218 |
| Enhancing m currents: a way out for neuropathic pain? | Frontiers in molecular neuroscience 20090101 |
| Low expression of Kv7/M channels facilitates intrinsic and network bursting in the developing rat hippocampus. | The Journal of physiology 20081115 |
| The synergistic inhibitory actions of oxcarbazepine on voltage-gated sodium and potassium currents in differentiated NG108-15 neuronal cells and model neurons. | The international journal of neuropsychopharmacology 20080801 |
| Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels. | Nature neuroscience 20080701 |
| Vascular KCNQ potassium channels as novel targets for the control of mesenteric artery constriction by vasopressin, based on studies in single cells, pressurized arteries, and in vivo measurements of mesenteric vascular resistance. | The Journal of pharmacology and experimental therapeutics 20080501 |
| ACh-induced depolarization in inner ear artery is generated by activation of a TRP-like non-selective cation conductance and inactivation of a potassium conductance. | Hearing research 20080501 |
| Dorsal-ventral gradient for neuronal plasticity in the embryonic spinal cord. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20080402 |
| N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator. | Molecular pharmacology 20080301 |
| Antihistamine mepyramine directly inhibits KCNQ/M channel and depolarizes rat superior cervical ganglion neurons. | Neuropharmacology 20080301 |
| K+ M-current regulates the transition to seizures in immature and adult hippocampus. | Epilepsia 20071101 |
| Cell-type specific modulation of intrinsic firing properties and subthreshold membrane oscillations by the M(Kv7)-current in neurons of the entorhinal cortex. | Journal of neurophysiology 20071101 |
| Quantal and nonquantal transmission in calyx-bearing fibers of the turtle posterior crista. | Journal of neurophysiology 20070901 |
| Molecular expression and pharmacological identification of a role for K(v)7 channels in murine vascular reactivity. | British journal of pharmacology 20070701 |
| Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants. | Nature chemical biology 20070501 |
| Modulation of ERG channels by XE991. | Basic & clinical pharmacology & toxicology 20070501 |
| Vasopressin stimulates action potential firing by protein kinase C-dependent inhibition of KCNQ5 in A7r5 rat aortic smooth muscle cells. | American journal of physiology. Heart and circulatory physiology 20070301 |
| M-channels (Kv7/KCNQ channels) that regulate synaptic integration, excitability, and spike pattern of CA1 pyramidal cells are located in the perisomatic region. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20070221 |
| Computational reconstruction of pacemaking and intrinsic electroresponsiveness in cerebellar Golgi cells. | Frontiers in cellular neuroscience 20070101 |
| Somatodendritic Kv7/KCNQ/M channels control interspike interval in hippocampal interneurons. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20061122 |
| The acrylamide (S)-1 differentially affects Kv7 (KCNQ) potassium channels. | Neuropharmacology 20061101 |
| Contribution of persistent Na+ current and M-type K+ current to somatic bursting in CA1 pyramidal cells: combined experimental and modeling study. | Journal of neurophysiology 20061001 |
| An M2-like muscarinic receptor enhances a delayed rectifier K+ current in rat sympathetic neurones. | British journal of pharmacology 20061001 |
| Studies of the effect of ionomycin on the KCNQ4 channel expressed in Xenopus oocytes. | Biochemical and biophysical research communications 20060915 |
| KCNQ/M-currents contribute to the resting membrane potential in rat visceral sensory neurons. | The Journal of physiology 20060815 |
| Retigabine and flupirtine exert neuroprotective actions in organotypic hippocampal cultures. | Neuropharmacology 20060801 |
| KCNQ channels mediate IKs, a slow K+ current regulating excitability in the rat node of Ranvier. | The Journal of physiology 20060515 |
| Dual mechanisms of angiotensin-induced activation of mouse sympathetic neurones. | The Journal of physiology 20060515 |
| KCNQ/Kv7 channel regulation of hippocampal gamma-frequency firing in the absence of synaptic transmission. | Journal of neurophysiology 20060501 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| High potassium concentrations protect inner and outer hair cells in the newborn rat culture from ischemia-induced damage. | Hearing research 20060501 |
| Linopirdine modulates calcium signaling and stimulus-secretion coupling in adrenal chromaffin cells by targeting M-type K+ channels and nicotinic acetylcholine receptors. | The Journal of pharmacology and experimental therapeutics 20060301 |
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