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10465-78-8

10465-78-8 | N1,N1,N2,N2-Tetramethyldiazene-1,2-dicarboxamide

CAS No: 10465-78-8 Catalog No: AG003SGQ MDL No:MFCD00008318

Product Description

Catalog Number:
AG003SGQ
Chemical Name:
N1,N1,N2,N2-Tetramethyldiazene-1,2-dicarboxamide
CAS Number:
10465-78-8
Molecular Formula:
C6H12N4O2
Molecular Weight:
172.1851
MDL Number:
MFCD00008318
IUPAC Name:
(3E)-3-(dimethylcarbamoylimino)-1,1-dimethylurea
InChI:
InChI=1S/C6H12N4O2/c1-9(2)5(11)7-8-6(12)10(3)4/h1-4H3/b8-7+
InChI Key:
VLSDXINSOMDCBK-BQYQJAHWSA-N
SMILES:
CN(C(=O)/N=N/C(=O)N(C)C)C
EC Number:
233-951-7
UNII:
86EQC90W32
NSC Number:
143013
UN Number:
2029

Properties

Complexity:
188  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
1  
Exact Mass:
172.096g/mol
Formal Charge:
0
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
172.188g/mol
Monoisotopic Mass:
172.096g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
65.3A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0.2  

Literature

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Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. The Journal of biological chemistry 20020419
Protein glutathionylation: coupling and uncoupling of glutathione to protein thiol groups in lymphocytes under oxidative stress and HIV infection. Molecular immunology 20020201
Glutathione might exert an important function in caerulein-stimulated amylase release in isolated rat pancreatic acini. Pancreas 20020101
Modulation of ICl(Ca) in vascular smooth muscle cells by oxidizing and cysteine-reactive reagents. Pflugers Archiv : European journal of physiology 20020101
Cystathionine pathway-dependent cytotoxicities of diethyl maleate and diamide in rat and human hepatoma-derived cell cultures. Alternatives to laboratory animals : ATLA 20020101
[Effect of diamide on protein oxidation and physico-chemical properties of lipids in erythrocyte membranes]. Biofizika 20020101
GSH depletion, K-Cl cotransport, and regulatory volume decrease in high-K/high-GSH dog red blood cells. American journal of physiology. Cell physiology 20011201
The influence of oxidation of membrane thiol groups on lysosomal proton permeability. The Biochemical journal 20011201
In vitro phagocytosis of carrier mouse red blood cells is increased by Band 3 cross-linking or diamide treatment. Biotechnology and applied biochemistry 20011201
Oxidative stress impairs nuclear proteins binding to the insulin responsive element in the GLUT4 promoter. Diabetologia 20011201
Differential in vitro and in vivo behavior of mouse ascorbate/Fe3+ and diamide oxidized erythrocytes. Bioscience reports 20011201
p38 MAP kinase mediates stress-induced leukotriene synthesis in a human B-lymphocyte cell line. Journal of leukocyte biology 20011101
Induction of mild intracellular redox imbalance inhibits proliferation of CaCo-2 cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20011001
Diamide derivatives and cycloartanes from the leaves of Aglaia elliptica. Chemical & pharmaceutical bulletin 20010901
Inhibition of protein tyrosine phosphatases suppresses P-selectin exocytosis in activated human platelets. Biochemical and biophysical research communications 20010824
Contrasting effects of thiol-modulating agents on endothelial NO bioactivity. American journal of physiology. Cell physiology 20010801
Redox regulation of the DNA repair function of the human AP endonuclease Ape1/ref-1. Antioxidants & redox signaling 20010801
Disulfide bonds stabilize JC virus capsid-like structure by protecting calcium ions from chelation. FEBS letters 20010706
Resolution, detection, and characterization of redox conformers of human HSF1. The Journal of biological chemistry 20010629
Determination of C4-C14 carboxylic acids by capillary zone electrophoresis. Application to the identification of diamide degradation products and partitioning studies. Journal of chromatography. A 20010622
Influence of oxidation and crosslinking on oxygen binding properties of mouse erythrocytes. Cell biochemistry and function 20010601
Selective disruption of cadherin/catenin complexes by oxidative stress in precision-cut mouse liver slices. Toxicological sciences : an official journal of the Society of Toxicology 20010601
Cellular titration of apoptosis with steady state concentrations of H(2)O(2): submicromolar levels of H(2)O(2) induce apoptosis through Fenton chemistry independent of the cellular thiol state. Free radical biology & medicine 20010501
Responses of thiols to an oxidant challenge: differences between blood and tissues in the rat. Chemico-biological interactions 20010314
Different metabolizing ability of thiol reactants in human and rat blood: biochemical and pharmacological implications. The Journal of biological chemistry 20010309
Multiple Yap1p-binding sites mediate induction of the yeast major facilitator FLR1 gene in response to drugs, oxidants, and alkylating agents. The Journal of biological chemistry 20010112
Expression of a glutamate decarboxylase homologue is required for normal oxidative stress tolerance in Saccharomyces cerevisiae. The Journal of biological chemistry 20010105
Cytotoxic constituents from leaves of Aglaia elliptifolia. Journal of natural products 20010101
NF kappa b signaling in posthypoxic endothelial cells: relevance to E-selectin expression and neutrophil adhesion. Journal of vascular research 20010101
Thiol-oxidizing agent diamide and acidic pH enhance lipid peroxidation of rat heart mitochondria and cardiolipin-cytochrome c complex. IUBMB life 20010101
Aggregation and sedimentation of mixtures of erythrocytes with different properties. Clinical hemorheology and microcirculation 20010101
Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes. The Journal of biological chemistry 19990618
Redox regulation of manganese superoxide dismutase. The American journal of physiology 19960701
Thiol modulation of TNF alpha and IL-1 induced MnSOD gene expression and activation of NF-kappa B. Molecular and cellular biochemistry 19950705

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