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Home > Imidazoles > 102203-18-9
102203-18-9 | Carbamimidothioic acid, 2-(1H-imidazol-5-yl)ethyl ester
CAS No: 102203-18-9 Catalog No: AG0006WV MDL No:
Product Description
Catalog Number:
AG0006WV
Chemical Name:
Carbamimidothioic acid, 2-(1H-imidazol-5-yl)ethyl ester
CAS Number:
102203-18-9
Molecular Formula:
C6H10N4S
Molecular Weight:
170.2354
IUPAC Name:
2-(1H-imidazol-5-yl)ethyl carbamimidothioate
InChI:
InChI=1S/C6H10N4S/c7-6(8)11-2-1-5-3-9-4-10-5/h3-4H,1-2H2,(H3,7,8)(H,9,10)
InChI Key:
PEHSVUKQDJULKE-UHFFFAOYSA-N
SMILES:
NC(=N)SCCc1cnc[nH]1
UNII:
677MJ4VPZC
Properties
Complexity:
139
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
170.063g/mol
Formal Charge:
0
Heavy Atom Count:
11
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
170.234g/mol
Monoisotopic Mass:
170.063g/mol
Rotatable Bond Count:
4
Topological Polar Surface Area:
104A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0.2
Literature
| Title | Journal |
|---|---|
| Proxyfan acts as a neutral antagonist of histamine H3 receptors in the feeding-related hypothalamic ventromedial nucleus. | British journal of pharmacology 20121101 |
| Molecular determinants of ligand binding modes in the histamine H(4) receptor: linking ligand-based three-dimensional quantitative structure-activity relationship (3D-QSAR) models to in silico guided receptor mutagenesis studies. | Journal of medicinal chemistry 20111208 |
| Histamine facilitates consolidation of fear extinction. | The international journal of neuropsychopharmacology 20111001 |
| Histamine H3 receptor agonists decrease hypothalamic histamine levels and increase stereotypical biting in mice challenged with methamphetamine. | Neurochemical research 20111001 |
| Involvement of histaminergic receptor mechanisms in the stimulation of NT-3 synthesis in astrocytes. | Neuropharmacology 20110601 |
| N-Alkenyl and cycloalkyl carbamates as dual acting histamine H3 and H4 receptor ligands. | Bioorganic & medicinal chemistry 20110501 |
| Ciproxifan, a histamine H₃-receptor antagonist / inverse agonist, modulates methamphetamine-induced sensitization in mice. | The European journal of neuroscience 20110401 |
| Antidiabetic properties of the histamine H3 receptor protean agonist proxyfan. | Endocrinology 20110301 |
| Histamine H3 receptor as a drug discovery target. | Journal of medicinal chemistry 20110113 |
| Histaminergic mechanisms for modulation of memory systems. | Neural plasticity 20110101 |
| Histamine H4 receptor agonists. | Bioorganic & medicinal chemistry letters 20101215 |
| Comparison of the pharmacological properties of human and rat histamine H(3)-receptors. | Biochemical pharmacology 20101101 |
| [Effect of H3R agonist, IMETIT on allergic rhinitis in guinea pigs]. | Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery 20100601 |
| [Substance P and its receptors are involved in the effect of histamine H3 receptor agonist, IMETIT on nasal allergic symptoms in guinea pigs]. | Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery 20100601 |
| Role of hydrophobic substituents on the terminal nitrogen of histamine in receptor binding and agonist activity: development of an orally active histamine type 3 receptor agonist and evaluation of its antistress activity in mice. | Journal of medicinal chemistry 20100513 |
| Different role of cAMP dependent protein kinase and CaMKII in H3 receptor regulation of histamine synthesis and release. | Neuroscience 20091215 |
| The ameliorating effects of NMDA receptor agonists on histamine H1 antagonist-induced memory and hippocampal theta disruptions are prevented by the H3 receptor agonist in rats. | Brain research bulletin 20090814 |
| Development of a selective and potent radioactive ligand for histamine H(3) receptors: A compound potentially useful for receptor occupancy studies. | Bioorganic & medicinal chemistry letters 20090801 |
| Urethane, but not pentobarbitone, attenuates presynaptic receptor function in rats: a contribution to the choice of anaesthetic. | British journal of pharmacology 20090801 |
| JNJ-10181457, a selective non-imidazole histamine H(3) receptor antagonist, normalizes acetylcholine neurotransmission and has efficacy in translational rat models of cognition. | Neuropharmacology 20090601 |
| Clobenpropit analogs as dual activity ligands for the histamine H3 and H4 receptors: synthesis, pharmacological evaluation, and cross-target QSAR studies. | Bioorganic & medicinal chemistry 20090601 |
| The role of histamine 3 receptors in the control of food intake in a seasonal model of obesity: the Siberian hamster. | Behavioural pharmacology 20090301 |
| Effects of histamine H(3) receptor activation on the behavioral-stimulant effects of methamphetamine and cocaine in mice and squirrel monkeys. | Pharmacology 20090201 |
| Pharmacologic attenuation of pelvic pain in a murine model of interstitial cystitis. | BMC urology 20090101 |
| Cloning and characterization of the monkey histamine H3 receptor isoforms. | European journal of pharmacology 20081228 |
| Participation of histamine H3 receptors in experimental allergic rhinitis of mice. | Journal of pharmacological sciences 20081001 |
| Autoregulation of McA-RH7777 hepatoma cell proliferation by histamine H3 receptors. | The Journal of pharmacology and experimental therapeutics 20080801 |
| Discovery of novel human histamine H4 receptor ligands by large-scale structure-based virtual screening. | Journal of medicinal chemistry 20080612 |
| Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function. | Neuropharmacology 20080516 |
| Histamine depolarizes neurons in the dorsal vagal complex. | Neuroscience letters 20080213 |
| Distinctive role of central histamine H3 receptor in various orexigenic pathways. | European journal of pharmacology 20080128 |
| Histamine H(3) receptor ligands modulate L-dopa-evoked behavioral responses and L-dopa derived extracellular dopamine in dopamine-denervated rat striatum. | Neurotoxicity research 20080101 |
| Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells. | BMC pharmacology 20080101 |
| Histamine H3-receptor signaling in cardiac sympathetic nerves: Identification of a novel MAPK-PLA2-COX-PGE2-EP3R pathway. | Biochemical pharmacology 20070415 |
| Modification of formalin-induced nociception by different histamine receptor agonists and antagonists. | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20070115 |
| Histamine H3 receptor agonist- and antagonist-evoked vacuous chewing movements in 6-OHDA-lesioned rats occurs in an absence of change in microdialysate dopamine levels. | European journal of pharmacology 20061215 |
| Histamine decreases myogenic tone in rat cerebral arteries by H2-receptor-mediated KV channel activation, independent of endothelium and cyclic AMP. | European journal of pharmacology 20061010 |
| Homologous down-regulation of histamine H3 receptors in rat striatal slices. | Synapse (New York, N.Y.) 20060801 |
| Regulation of norepinephrine release from isolated bovine irides by histamine. | Neurochemical research 20060701 |
| Histamine H3 receptor agonists reduce L-dopa-induced chorea, but not dystonia, in the MPTP-lesioned nonhuman primate model of Parkinson's disease. | Movement disorders : official journal of the Movement Disorder Society 20060601 |
| Histamine excites neonatal rat sympathetic preganglionic neurons in vitro via activation of H1 receptors. | Journal of neurophysiology 20060401 |
| G protein-dependent pharmacology of histamine H3 receptor ligands: evidence for heterogeneous active state receptor conformations. | The Journal of pharmacology and experimental therapeutics 20050701 |
| H3 autoreceptors modulate histamine synthesis through calcium/calmodulin- and cAMP-dependent protein kinase pathways. | Molecular pharmacology 20050101 |
| Significance of Conversation between Mast Cells and Nerves. | Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20050101 |
| Cloning and expression of the mouse histamine H3 receptor: evidence for multiple isoforms. | Journal of neurochemistry 20040901 |
| Histamine H3 receptors modulate reactive hyperemia in rat gut. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20040901 |
| Meta-substituted aryl(thio)ethers as potent partial agonists (or antagonists) for the histamine H3 receptor lacking a nitrogen atom in the side chain. | Journal of medicinal chemistry 20040603 |
| Involvement of histamine H4 and H1 receptors in scratching induced by histamine receptor agonists in Balb C mice. | British journal of pharmacology 20040501 |
| Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation. | British journal of pharmacology 20040501 |
| Involvement of central and peripheral histamine H(3) receptors in the control of the vascular tone and oxygen uptake in the mesenteric circulation of the rat. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20040301 |
| Role of histamine receptors in the regulation of edema and circulation postburn. | Burns : journal of the International Society for Burn Injuries 20031201 |
| Histamine induces cytoskeletal changes in human eosinophils via the H(4) receptor. | British journal of pharmacology 20031101 |
| Generation and characterization of highly constitutive active histamine H3 receptors. | The Journal of pharmacology and experimental therapeutics 20031001 |
| Waking selective neurons in the posterior hypothalamus and their response to histamine H3-receptor ligands: an electrophysiological study in freely moving cats. | Behavioural brain research 20030915 |
| An in vitro study of histamine on the pulmonary artery of the Wistar-Kyoto and spontaneously hypertensive rats. | European journal of pharmacology 20030530 |
| Cyclopropane-based conformational restriction of histamine. (1S,2S)-2-(2-aminoethyl)-1-(1H-imidazol-4-yl)cyclopropane, a highly selective agonist for the histamine H3 receptor, having a cis-cyclopropane structure. | Journal of medicinal chemistry 20030508 |
| Molecular and pharmacological characterization of the mouse histamine H3 receptor. | European journal of pharmacology 20030425 |
| Histaminergic modulation of the intact respiratory network of adult mice. | Pflugers Archiv : European journal of physiology 20030201 |
| Characteristics of recombinantly expressed rat and human histamine H3 receptors. | European journal of pharmacology 20021018 |
| Influence of bulky substituents on histamine h(3) receptor agonist/antagonist properties. | Journal of medicinal chemistry 20020829 |
| Functional analysis of histamine receptor subtypes involved in endothelium-mediated relaxation of the human uterine artery. | Clinical and experimental pharmacology & physiology 20020801 |
| Molecular cloning and pharmacology of functionally distinct isoforms of the human histamine H(3) receptor. | Neuropharmacology 20020601 |
| Rodent antinociception following acute treatment with different histamine receptor agonists and antagonists. | Pharmacology, biochemistry, and behavior 20020601 |
| The role of transmembrane helix 5 in agonist binding to the human H3 receptor. | The Journal of pharmacology and experimental therapeutics 20020501 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| Presynaptic H3 autoreceptors modulate histamine synthesis through cAMP pathway. | Molecular pharmacology 20020101 |
| Histamine H3-receptor-mediated [35S]GTP gamma[S] binding: evidence for constitutive activity of the recombinant and native rat and human H3 receptors. | British journal of pharmacology 20020101 |
| Constitutive activity of histamine h(3) receptors stably expressed in SK-N-MC cells: display of agonism and inverse agonism by H(3) antagonists. | The Journal of pharmacology and experimental therapeutics 20011201 |
| Pharmacological analysis of immepip and imetit homologues. Further evidence for histamine H(3) receptor heterogeneity? | Behavioural brain research 20011015 |
| Comparison of human, mouse, rat, and guinea pig histamine H4 receptors reveals substantial pharmacological species variation. | The Journal of pharmacology and experimental therapeutics 20011001 |
| Histaminergic modulation of GABAergic transmission in rat ventromedial hypothalamic neurones. | The Journal of physiology 20010801 |
| Genomic organization and characterization of splice variants of the human histamine H3 receptor. | The Biochemical journal 20010415 |
| Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. | Molecular pharmacology 20010301 |
| Cloning, expression, and pharmacological characterization of a novel human histamine receptor. | Molecular pharmacology 20010301 |
| Cloning and characterization of a novel human histamine receptor. | The Journal of pharmacology and experimental therapeutics 20010301 |
| The rat H3 receptor: gene organization and multiple isoforms. | Biochemical and biophysical research communications 20010112 |
| Cloning of rat histamine H(3) receptor reveals distinct species pharmacological profiles. | The Journal of pharmacology and experimental therapeutics 20000601 |
| Effects of histamine H3 receptor agonists and antagonists on cognitive performance and scopolamine-induced amnesia. | Behavioural brain research 19991001 |
| Inhibitory H3 receptors on sympathetic nerves of the pithed rat: activation by endogenous histamine and operation in spontaneously hypertensive rats. | Naunyn-Schmiedeberg's archives of pharmacology 19970201 |
| S-[2-(4-imidazolyl)ethyl]isothiourea, a highly specific and potent histamine H3 receptor agonist. | The Journal of pharmacology and experimental therapeutics 19921001 |
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