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102146-07-6

102146-07-6 | 1H-Purine-2,6-dione, 8-cyclopentyl-3,9-dihydro-1,3-dipropyl-

CAS No: 102146-07-6 Catalog No: AG0006QF MDL No:MFCD00055117

Product Description

Catalog Number:
AG0006QF
Chemical Name:
1H-Purine-2,6-dione, 8-cyclopentyl-3,9-dihydro-1,3-dipropyl-
CAS Number:
102146-07-6
Molecular Formula:
C16H24N4O2
Molecular Weight:
304.3874
MDL Number:
MFCD00055117
IUPAC Name:
8-cyclopentyl-1,3-dipropyl-7H-purine-2,6-dione
InChI:
InChI=1S/C16H24N4O2/c1-3-9-19-14-12(15(21)20(10-4-2)16(19)22)17-13(18-14)11-7-5-6-8-11/h11H,3-10H2,1-2H3,(H,17,18)
InChI Key:
FFBDFADSZUINTG-UHFFFAOYSA-N
SMILES:
CCCn1c2[nH]c(nc2c(=O)n(c1=O)CCC)C1CCCC1
UNII:
9PTP4FOI9E

Properties

Complexity:
436  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
304.19g/mol
Formal Charge:
0
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
304.394g/mol
Monoisotopic Mass:
304.19g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
69.3A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4  

Literature

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Synthesis of a series of 8-(substituted-phenyl)xanthines and a study on the effects of substitution pattern of phenyl substituents on affinity for adenosine A(1) and A(2A) receptors. European journal of medicinal chemistry 20090501
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Regulation of somatostatin release by adenosine in the mouse stomach. The Journal of pharmacology and experimental therapeutics 20090501
Cardioprotection induced by adenosine A1 receptor agonists in a cardiac cell ischemia model involves cooperative activation of adenosine A2A and A2B receptors by endogenous adenosine. Journal of cardiovascular pharmacology 20090501
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Characterization of the A2B adenosine receptor from mouse, rabbit, and dog. The Journal of pharmacology and experimental therapeutics 20090401
Early renal post-ischaemic tissue damage and dysfunction with contribution of A1-adenosine receptor activation in rat. Nephrology (Carlton, Vic.) 20090401
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Endogenous activation of adenosine A1 receptors promotes post-ischemic electrocortical burst suppression. Neuroscience 20090331
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Adenosine A1 and A2a receptors modulate insulinemia, glycemia, and lactatemia in fetal sheep. American journal of physiology. Regulatory, integrative and comparative physiology 20090301
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Adenosine A(1) and A(2A) receptors in mouse prefrontal cortex modulate acetylcholine release and behavioral arousal. The Journal of neuroscience : the official journal of the Society for Neuroscience 20090121
Brainstem adenosine A1 receptor signaling masks phosphorylated extracellular signal-regulated kinase 1/2-dependent hypotensive action of clonidine in conscious normotensive rats. The Journal of pharmacology and experimental therapeutics 20090101
Adenosine A1 and A3 receptor agonists inhibit nonadrenergic, noncholinergic relaxations in the guinea pig isolated trachea. Respiration; international review of thoracic diseases 20090101
Effects of adenosine A1 receptor antagonism on lipogenesis and lipolysis in isolated rat adipocytes. Physiological research 20090101
Anti-nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: role of A1 adenosine receptors. British journal of pharmacology 20090101
Recombinant mouse PAP has pH-dependent ectonucleotidase activity and acts through A(1)-adenosine receptors to mediate antinociception. PloS one 20090101
Antidipsogenic effects of central adenosine-5'-triphosphate. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20090101
Drug-eluting stent for delivery of signal pathway-specific 1,3-dipropyl-8-cyclopentyl xanthine. Molecular pharmaceutics 20090101
Selective deletion of the A1 adenosine receptor abolishes heart-rate slowing effects of intravascular adenosine in vivo. PloS one 20090101
Involvement of A(1) adenosine receptors in osmotic volume regulation of retinal glial cells in mice. Molecular vision 20090101
Presynaptic M1, M2, and A1 receptors play roles in tetanic fade induced by pancuronium or cisatracurium. Journal of anesthesia 20090101
Purinergic mechanosensory transduction and visceral pain. Molecular pain 20090101
Adenosine modulates alpha2-adrenergic receptors within specific subnuclei of the nucleus tractus solitarius in normotensive and spontaneously hypertensive rats. Hypertension research : official journal of the Japanese Society of Hypertension 20081201
The potential role of the nodose ganglion adenosine A1 receptor in regulation of breathing in anaesthetized rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20081201
Tianeptine: an antidepressant with memory-protective properties. Current neuropharmacology 20081201
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia. Journal of medicinal chemistry 20081127
Adenosine modulates excitatory synaptic transmission and suppresses neuronal death induced by ischaemia in rat spinal motoneurones. Pflugers Archiv : European journal of physiology 20081101
MDA-MB-231 produces ATP-mediated ICAM-1-dependent facilitation of the attachment of carcinoma cells to human lymphatic endothelial cells. American journal of physiology. Cell physiology 20081101
Adenosine and adenosine uptake inhibitors potentiate the neuromuscular blocking action of rocuronium mediated by adenosine A(1) receptors in isolated rat diaphragms. Acta anaesthesiologica Scandinavica 20081101
Adenosine A1 and A3 receptors protect astrocytes from hypoxic damage. European journal of pharmacology 20081031
The effects of adenosine A2A receptor antagonists on haloperidol-induced movement disorders in primates. Psychopharmacology 20081001
Activation of adenosine A1 receptor-induced neural stem cell proliferation via MEK/ERK and Akt signaling pathways. Journal of neuroscience research 20081001
Correlation of intrinsic optical signal, cerebral blood flow, and evoked potentials during activation of rat somatosensory cortex. Journal of neurosurgery 20081001
Selective inhibitory effect of adenosine A1 receptor agonists on the proliferation of human tumor cell lines. Iranian biomedical journal 20081001
Activating parabrachial cannabinoid CB1 receptors selectively stimulates feeding of palatable foods in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience 20080924
Adenosine receptor subtypes in the airways responses to 5'-adenosine monophosphate inhalation of sensitized guinea-pigs. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20080901
2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists. Journal of medicinal chemistry 20080814
Regional haemodynamic responses to adenosine receptor activation vary across time following lipopolysaccharide treatment in conscious rats. British journal of pharmacology 20080801
Effects of adenosine receptor antagonists on amitriptyline-induced QRS prolongation in isolated rat hearts. Clinical toxicology (Philadelphia, Pa.) 20080801
The interaction of gabapentin and N6-(2-phenylisopropyl)-adenosine R-(-)isomer (R-PIA) on mechanical allodynia in rats with a spinal nerve ligation. Journal of Korean medical science 20080801
Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. Journal of medicinal chemistry 20080724
Effect of purines on calcium-independent acetylcholine release at the mouse neuromuscular junction. Neuroscience 20080717
Ischaemic and pharmacological preconditionings protect liver via adenosine and redox status following hepatic ischaemia/reperfusion in rats. Clinical science (London, England : 1979) 20080701
Adenosine A1 receptors inhibit GABAergic transmission in rat tuberomammillary nucleus neurons. Journal of neurochemistry 20080701
Adenosine induces a cholinergic tracheal reflex contraction in guinea pigs in vivo via an adenosine A1 receptor-dependent mechanism. Journal of applied physiology (Bethesda, Md. : 1985) 20080701
Sex differences in the neurotoxic effects of adenosine A1 receptor antagonism during ethanol withdrawal: reversal with an A1 receptor agonist or an NMDA receptor antagonist. Alcoholism, clinical and experimental research 20080701
Adenosine A1 receptor activation mediates NMDA receptor activity in a pertussis toxin-sensitive manner during normoxia but not anoxia in turtle cortical neurons. Brain research 20080605
Endogenous A1 adenosine receptors protect against hepatic ischemia reperfusion injury in mice. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20080601
Inosine and equilibrative nucleoside transporter 2 contribute to hypoxic preconditioning in the murine cardiomyocyte HL-1 cell line. American journal of physiology. Heart and circulatory physiology 20080601
Synthesis, ligand-receptor modeling studies and pharmacological evaluation of novel 4-modified-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent and selective human A3 adenosine receptor antagonists. Bioorganic & medicinal chemistry 20080601
Effect of A2B adenosine receptor gene ablation on proinflammatory adenosine signaling in mast cells. Journal of immunology (Baltimore, Md. : 1950) 20080601
Activity of adenosine receptors type 1 Is required for CX3CL1-mediated neuroprotection and neuromodulation in hippocampal neurons. Journal of immunology (Baltimore, Md. : 1950) 20080601
Involvement of the adenosine A1 and A2A receptors in the antidepressant-like effect of zinc in the forced swimming test. Progress in neuro-psychopharmacology & biological psychiatry 20080515
Caffeine and a selective adenosine A(2B) receptor antagonist but not imidazoline receptor antagonists modulate antinociception induced by diphenyl diselenide in mice. Neuroscience letters 20080509
Adenosine-mediated alteration of vascular reactivity and inflammation in a murine model of asthma. American journal of physiology. Heart and circulatory physiology 20080501
Frequency facilitation at mossy fiber-CA3 synapses of freely behaving rats is regulated by adenosine A1 receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience 20080430
Hypotensive effects of intravenously administered uridine and cytidine in conscious rats: involvement of adenosine receptors. European journal of pharmacology 20080414
Up-regulation of adenosine receptors in the frontal cortex in Alzheimer's disease. Brain pathology (Zurich, Switzerland) 20080401
A positive inotropic effect of ATP in the human cardiac atrium. American journal of physiology. Heart and circulatory physiology 20080401
Administration of phosphodiesterase inhibitors and an adenosine A1 receptor antagonist induces phrenic nerve recovery in high cervical spinal cord injured rats. Experimental neurology 20080401
Changes in the control of gastric motor activity during metamorphosis in the amphibian Xenopus laevis, with special emphasis on purinergic mechanisms. The Journal of experimental biology 20080401
Derivatives of 4-amino-6-hydroxy-2-mercaptopyrimidine as novel, potent, and selective A3 adenosine receptor antagonists. Journal of medicinal chemistry 20080327
A new generation of adenosine receptor antagonists: from di- to trisubstituted aminopyrimidines. Bioorganic & medicinal chemistry 20080315
Combined antagonism of glutamate mGlu5 and adenosine A2A receptors interact to regulate alcohol-seeking in rats. The international journal of neuropsychopharmacology 20080301
Synthesis and adenosine receptor binding studies of some novel triazolothienopyrimidines. European journal of medicinal chemistry 20080301
Adenosine receptor ligands protect against a combination of apoptotic and necrotic cell death in cerebellar granule neurons. Experimental brain research 20080301
Alcohol related changes in regulation of NMDA receptor functions. Current neuropharmacology 20080301
Identification of novel, water-soluble, 2-amino-N-pyrimidin-4-yl acetamides as A2A receptor antagonists with in vivo efficacy. Journal of medicinal chemistry 20080214
Stimulation of adenosine A2A receptor inhibits LPS-induced expression of intercellular adhesion molecule 1 and production of TNF-alpha in human peripheral blood mononuclear cells. Shock (Augusta, Ga.) 20080201
Cloning and functional expression of a novel Gi protein-coupled receptor for adenine from mouse brain. Molecular pharmacology 20080201
Visualisation of the effects of dilazep on rat afferent and efferent arterioles in vivo. Hypertension research : official journal of the Japanese Society of Hypertension 20080201
A1 and A2A receptor activation by endogenous adenosine is required for VIP enhancement of K+ -evoked [3H]-GABA release from rat hippocampal nerve terminals. Neuroscience letters 20080117
Ozone oxidative preconditioning is mediated by A1 adenosine receptors in a rat model of liver ischemia/ reperfusion. Transplant international : official journal of the European Society for Organ Transplantation 20080101
Connexins 37 and 40 transduce purinergic signals mediating renal autoregulation. American journal of physiology. Regulatory, integrative and comparative physiology 20080101
Renal interstitial adenosine is increased in angiotensin II-induced hypertensive rats. American journal of physiology. Renal physiology 20080101
Effect of glutamate intake during gestation on adenosine A(1) receptor/adenylyl cyclase pathway in both maternal and fetal rat brain. Journal of neurochemistry 20080101
Tuning adenosine A1 and A2A receptors activation mediates L-citrulline-induced inhibition of [3H]-acetylcholine release depending on nerve stimulation pattern. Neurochemistry international 20080101
Anti-inflammatory preconditioning by agonists of adenosine A1 receptor. PloS one 20080101
Effect of the pyridoindole SMe1EC2 and compounds affecting A(1) and A(2A) adenosine receptors in rat hippocampus under ischemia in vitro. Pharmacological reports : PR 20080101
Rhythm generation by the pre-Bötzinger complex in medullary slice and island preparations: effects of adenosine A(1) receptor activation. BMC neuroscience 20080101
A role of p38 mitogen-activated protein kinase in adenosine A₁ receptor-mediated synaptic depotentiation in area CA1 of the rat hippocampus. Molecular brain 20080101
Altered ATP release and metabolism in dorsal root ganglia of neuropathic rats. Molecular pain 20080101
[Influence of the antagonist of adenosine A1 receptors, 8-cyclopentyl-1 ,3-dipropylxanthine, upon the anticonvulsant activity of antiepileptic drugs in mice]. Przeglad lekarski 20080101
Protective effect of adenosine in diabetic neuropathic pain is mediated through adenosine A1-receptors. Indian journal of physiology and pharmacology 20080101
The effect of caffeine to increase reaction time in the rat during a test of attention is mediated through antagonism of adenosine A2A receptors. Behavioural brain research 20071211
Protective roles of adenosine A1, A2A, and A3 receptors in skeletal muscle ischemia and reperfusion injury. American journal of physiology. Heart and circulatory physiology 20071201
C-Jun N-terminal kinase regulates adenosine A1 receptor-mediated synaptic depression in the rat hippocampus. Neuropharmacology 20071201
Up-regulation of adenosine A1 receptors in frontal cortex from Pick's disease cases. The European journal of neuroscience 20071201
Adenosine A1 receptor-mediated inhibition of dopamine release from rat striatal slices is modulated by D1 dopamine receptors. The European journal of neuroscience 20071201
5-amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: a versatile scaffold to obtain potent and selective A3 adenosine receptor antagonists. Journal of medicinal chemistry 20071115
Offsetting of aberrations associated with seizure proneness in rat hippocampus area CA1 by theta pulse stimulation-induced activity pattern. Neuroscience 20071109
Hexarelin suppresses cardiac fibroblast proliferation and collagen synthesis in rat. American journal of physiology. Heart and circulatory physiology 20071101
Adenosine A(1) receptor mediates delayed cardioprotective effect of sildenafil in mouse. Journal of molecular and cellular cardiology 20071101
Theophylline inhibits free oxygen radicals production by human monocytes via phosphodiesterase inhibition. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20071101
Purinergic modulation of glutamate release under ischemic-like conditions in the hippocampus. Neuroscience 20071012
Modelling the restoration of wild-type dynamic behaviour in DeltaF508-CFTR NBD1 by 8-cyclopentyl-1,3-dipropylxanthine. Journal of molecular graphics & modelling 20071001
Modulation of postsynaptic potentials in rat cortical neurons by valerian extracts macerated with different alcohols: involvement of adenosine A(1)- and GABA(A)-receptors. Phytotherapy research : PTR 20071001
Influence of adenosine A(1)-receptor blockade and vagotomy on the gasping and heart rate response to hypoxia in rats during early postnatal maturation. Journal of applied physiology (Bethesda, Md. : 1985) 20071001
Caffeine and accumbens shell dopamine. Journal of neurochemistry 20071001
Dual acting antioxidant A1 adenosine receptor agonists. Bioorganic & medicinal chemistry letters 20071001
Pharmacologic characterization of novel adenosine A2A receptor agonists in equine neutrophils. American journal of veterinary research 20070901
Ectonucleotidases in Müller glial cells of the rodent retina: Involvement in inhibition of osmotic cell swelling. Purinergic signalling 20070901
New 2-arylpyrazolo[3,4-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies. Journal of medicinal chemistry 20070823
Indomethacin stimulates activity and expression of ecto-5'-nucleotidase/CD73 in glioma cell lines. European journal of pharmacology 20070813
Determination of adenosine effects and adenosine receptors in murine corpus cavernosum. The Journal of pharmacology and experimental therapeutics 20070801
The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without affecting blood pressure. British journal of pharmacology 20070801
Activation of the A1 adenosine receptor increases insulin-stimulated glucose transport in isolated rat soleus muscle. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 20070801
Co-localization and functional cross-talk between A1 and P2Y1 purine receptors in rat hippocampus. The European journal of neuroscience 20070801
Presynaptic adenosine A1 receptors modulate excitatory synaptic transmission in the posterior piriform cortex in rats. Brain research 20070702
Adenosine stimulates the basolateral 50 pS K channels in the thick ascending limb of the rat kidney. American journal of physiology. Renal physiology 20070701
ATP modulates the release of noradrenaline through two different prejunctional receptors on the adrenergic nerves of rat prostate. Clinical and experimental pharmacology & physiology 20070701
L-citrulline inhibits [3H]acetylcholine release from rat motor nerve terminals by increasing adenosine outflow and activation of A1 receptors. British journal of pharmacology 20070601
Endogenous expression of adenosine A1, A2 and A3 receptors in rat C6 glioma cells. Neurochemical research 20070601
Activity-dependent depression of local excitatory connections in the CA1 region of mouse hippocampus. Journal of neurophysiology 20070601
Role of P2 purinergic receptors in synaptic transmission under normoxic and ischaemic conditions in the CA1 region of rat hippocampal slices. Purinergic signalling 20070601
Staurosporine-induced apoptosis in astrocytes is prevented by A1 adenosine receptor activation. Neuroscience letters 20070511
The enhancement of dopamine D1 receptor desensitization by adenosine A1 receptor activation. European journal of pharmacology 20070507
Developmental changes of purinergic control of intestinal motor activity during metamorphosis in the African clawed frog, Xenopus laevis. American journal of physiology. Regulatory, integrative and comparative physiology 20070501
Role of adenosine receptor subtypes in rat jejunum in unfed state versus glucose-induced hyperemia. The Journal of surgical research 20070501
Suppression of reactive oxygen species production enhances neuronal survival in vitro and in vivo in the anoxia-tolerant turtle Trachemys scripta. Journal of neurochemistry 20070501
Ischemic postconditioning reduces infarct size by activation of A1 receptors and K+(ATP) channels in both normal and hypercholesterolemic rabbits. Journal of cardiovascular pharmacology 20070501
Reduced basal and lipopolysaccharide-stimulated adenosine A1 receptor expression in the brain of nuclear factor-kappaB p50-/- mice. Neuroscience 20070425
Disruption of adenosinergic modulation of ventilation at rest and during hypercapnia by neonatal caffeine in young rats: role of adenosine A(1) and A(2A) receptors. American journal of physiology. Regulatory, integrative and comparative physiology 20070401
Antilipolytic activity of a novel partial A1 adenosine receptor agonist devoid of cardiovascular effects: comparison with nicotinic acid. The Journal of pharmacology and experimental therapeutics 20070401
Does nitric oxide modulate transmitter release at the mammalian neuromuscular junction? Clinical and experimental pharmacology & physiology 20070401
Mechanisms of direct peritoneal resuscitation-mediated splanchnic hyperperfusion following hemorrhagic shock. Shock (Augusta, Ga.) 20070401
Synergistic effects of adenosine A2A antagonist and L-DOPA on rotational behaviors in 6-hydroxydopamine-induced hemi-Parkinsonian mouse model. Journal of pharmacological sciences 20070301
Effect of 2-(6-cyano-1-hexyn-1-yl)adenosine on ocular blood flow in rabbits. Life sciences 20070227
2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. Journal of medicinal chemistry 20070222
Ischemic preconditioning modulates ischemia-reperfusion injury in the rat lung: role of adenosine receptors. European journal of pharmacology 20070205
Effects of tianeptine on onset time of pentylenetetrazole-induced seizures in mice: possible role of adenosine A1 receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070201
Presynaptic modulation of parallel fibre signalling to Bergmann glia. Neuropharmacology 20070201
Tonic adenosine A1 and A2A receptor activation is required for the excitatory action of VIP on synaptic transmission in the CA1 area of the hippocampus. Neuropharmacology 20070201
ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor. The Journal of pharmacology and experimental therapeutics 20070201
Pretreatment with adenosine and adenosine A1 receptor agonist protects against intestinal ischemia-reperfusion injury in rat. World journal of gastroenterology 20070128
Structure-activity relationship study of prion inhibition by 2-aminopyridine-3,5-dicarbonitrile-based compounds: parallel synthesis, bioactivity, and in vitro pharmacokinetics. Journal of medicinal chemistry 20070111
Depletion of ATP and release of presynaptic inhibition in the CA1 region of hippocampal slices during hypoglycemic hypoxia. Neuroscience letters 20070103
The A2a/A2b receptor antagonist ZM-241385 blocks the cardioprotective effect of adenosine agonist pretreatment in in vivo rat myocardium. American journal of physiology. Heart and circulatory physiology 20070101
A comparison of the antagonist affinities for the Gi- and Gs-coupled states of the human adenosine A1-receptor. The Journal of pharmacology and experimental therapeutics 20070101
Modulation of ischaemic contracture in mouse hearts: a 'supraphysiological' response to adenosine. Experimental physiology 20070101
Contractile activity of ATP and diadenosine tetraphosphate on urinary bladder in the rat: role of A1- and P2X-purinoceptors and nitric oxide. Autonomic & autacoid pharmacology 20070101
Effects of adenosine receptor antagonists on amitriptyline-induced vasodilation in rat isolated aorta. Clinical toxicology (Philadelphia, Pa.) 20070101
Regulation of pharmacology by hetero-oligomerization between A1 adenosine receptor and P2Y2 receptor. Biochemical and biophysical research communications 20061215
Co-modulation of acute ethanol-induced motor impairment by mouse cerebellar adenosinergic A1 and GABA(A) receptor systems. Brain research bulletin 20061211
Loss of vascular adenosine A1 receptors with age in the rat heart. Vascular pharmacology 20061201
A preliminary study on the interaction of fluvoxamine and adenosine receptor on isolated Guinea-pig atria. The International journal of neuroscience 20061201
Moderate cerebral venous congestion induces rapid cerebral protection via adenosine A1 receptor activation. Brain research 20061129
Effects of postconditioning of adenosine and acetylcholine on the ischemic isolated rat ventricular myocytes. European journal of pharmacology 20061107
NAD(P)H fluorescence transients after synaptic activity in brain slices: predominant role of mitochondrial function. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20061101
Endogenous activation of adenosine A(1) receptors accelerates ischemic suppression of spontaneous electrocortical activity. Journal of neurophysiology 20061101
Flavonoids as antagonists at A1 adenosine receptors. Phytotherapy research : PTR 20061101
Nitric oxide-induced adenosine inhibition of hippocampal synaptic transmission depends on adenosine kinase inhibition and is cyclic GMP independent. The European journal of neuroscience 20061101
Intrahepatic adenosine-mediated activation of hepatorenal reflex is via A1 receptors in rats. Canadian journal of physiology and pharmacology 20061101
Novel selective antagonist radioligands for the pharmacological study of A(2B) adenosine receptors. Purinergic signalling 20061101
Activation of adenosine A1 receptor modulates dopamine D1 receptor activity in stably cotransfected human embryonic kidney 293 cells. European journal of pharmacology 20061024
Chronic activation of spinal adenosine A1 receptors results in hypersensitivity. Neuroreport 20061023
Modulation of dopamine D1 receptor signaling by adenosine A1 receptors in Sf9 cells requires expression of Gi proteins. Neuroscience letters 20061009
Activation of adenosine A1 receptors reduces anxiety-like behavior during acute ethanol withdrawal (hangover) in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20061001
Adenosine A1 receptors mediate mobilization of calcium in human bronchial smooth muscle cells. American journal of respiratory cell and molecular biology 20061001
Adenosine sensory transduction pathways contribute to activation of the sensory irritation response to inspired irritant vapors. Toxicological sciences : an official journal of the Society of Toxicology 20061001
ST 1535: a preferential A2A adenosine receptor antagonist. The international journal of neuropsychopharmacology 20061001
Contribution of hepatic adenosine A1 receptors to renal dysfunction associated with acute liver injury in rats. Hepatology (Baltimore, Md.) 20061001
Presynaptic inhibition of spontaneous acetylcholine release mediated by P2Y receptors at the mouse neuromuscular junction. Neuroscience 20060929
Respiratory and body temperature modulation by adenosine A1 receptors in the anteroventral preoptic region during normoxia and hypoxia. Respiratory physiology & neurobiology 20060928
Increased density and synapto-protective effect of adenosine A2A receptors upon sub-chronic restraint stress. Neuroscience 20060915
Evidence for both adenosine A1 and A2A receptors activating single vagal sensory C-fibres in guinea pig lungs. The Journal of physiology 20060901
The role of adenosine in the early respiratory and cardiovascular changes evoked by chronic hypoxia in the rat. The Journal of physiology 20060815
Role of adenosine A1 receptors in the modulation of dopamine D1 and adenosine A2A receptor signaling in the neostriatum. Neuroscience 20060811
Adenosine is upregulated during peritonitis and is involved in downregulation of inflammation. Kidney international 20060801
Inhibitory responses to exogenous adenosine in murine proximal and distal colon. British journal of pharmacology 20060801
Potentiation of adenosine A1 receptor agonist CPA-induced antinociception by paeoniflorin in mice. Biological & pharmaceutical bulletin 20060801
Improving potency, selectivity, and water solubility of adenosine A1 receptor antagonists: xanthines modified at position 3 and related pyrimido[1,2,3-cd]purinediones. ChemMedChem 20060801
[Action of AMP579 and adenosine on potassium or sodium ionic channels in isolated rat and guinea pig ventricular myocytes]. Yao xue xue bao = Acta pharmaceutica Sinica 20060801
DPCPX-resistant hypoxic synaptic depression in the CA1 region of hippocampal slices: possible role of intracellular accumulation of monocarboxylates. Neuroscience letters 20060731
Role of A1 adenosine receptor in the regulation of coronary flow. American journal of physiology. Heart and circulatory physiology 20060701
Adenosine receptor antagonism in acute tacrolimus toxicity. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20060701
Adenosine A2A receptor mediated protective effect of 2-(6-cyano-1-hexyn-1-yl)adenosine on retinal ischaemia/reperfusion damage in rats. The British journal of ophthalmology 20060701
Negative cross-talk between presynaptic adenosine and acetylcholine receptors. The European journal of neuroscience 20060701
Caffeine inhibition of rat carotid body chemoreceptors is mediated by A2A and A2B adenosine receptors. Journal of neurochemistry 20060701
4-amido-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-ones as new potent and selective human A3 adenosine receptor antagonists. synthesis, pharmacological evaluation, and ligand-receptor modeling studies. Journal of medicinal chemistry 20060629
Novel 1,3-disubstituted 8-(1-benzyl-1H-pyrazol-4-yl) xanthines: high affinity and selective A2B adenosine receptor antagonists. Journal of medicinal chemistry 20060615
A1 adenosine receptor knockout mice are protected against acute radiocontrast nephropathy in vivo. American journal of physiology. Renal physiology 20060601
Paeoniflorin attenuates neuroinflammation and dopaminergic neurodegeneration in the MPTP model of Parkinson's disease by activation of adenosine A1 receptor. British journal of pharmacology 20060601
Valerian extract Ze 911 inhibits postsynaptic potentials by activation of adenosine A1 receptors in rat cortical neurons. Planta medica 20060601
Peripheral anti-hyperalgesia by oxcarbazepine: involvement of adenosine A1 receptors. Die Pharmazie 20060601
A novel partial agonist of the A(1)-adenosine receptor and evidence of receptor homogeneity in adipocytes. The Journal of pharmacology and experimental therapeutics 20060501
Postconditioning protects rabbit hearts through a protein kinase C-adenosine A2b receptor cascade. Cardiovascular research 20060501
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Characterization of adenosine receptors in the human bladder carcinoma T24 cell line. European journal of pharmacology 20060424
Involvement of adenosine A1 and A2A receptors in (-)-linalool-induced antinociception. Life sciences 20060418
Mechanism of adenosine-induced airways obstruction in allergic guinea pigs. British journal of pharmacology 20060401
Post-hypoxic hypoperfusion is associated with suppression of cerebral metabolism and increased tissue oxygenation in near-term fetal sheep. The Journal of physiology 20060401
Radioligand binding and functional responses of ligands for human recombinant adenosine A(3) receptors. Autonomic & autacoid pharmacology 20060401
Peripheral antinociception by carbamazepine in an inflammatory mechanical hyperalgesia model in the rat: a new target for carbamazepine? Journal of pharmacological sciences 20060401
Role of the second transmembrane domain of rat adenosine A1 receptor in ligand-receptor interaction. Biochemical pharmacology 20060314
Progress in the pursuit of therapeutic adenosine receptor antagonists. Medicinal research reviews 20060301
Allosteric modulation, thermodynamics and binding to wild-type and mutant (T277A) adenosine A1 receptors of LUF5831, a novel nonadenosine-like agonist. British journal of pharmacology 20060301
NMDA-induced preconditioning attenuates synaptic plasticity in the rat hippocampus. Brain research 20060216
Activation of receptors negatively coupled to adenylate cyclase is required for induction of long-term synaptic depression at Schaffer collateral-CA1 synapses. Journal of neurobiology 20060215
Combination of adenosine A1 and A2A receptor blocking agents induces caffeine-like locomotor stimulation in mice. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20060201
Adenosine A1 receptor antagonist blunts urinary potassium excretion, but not renal hemodynamic effects, induced by carbonic anhydrase inhibitor in rats. The Journal of pharmacology and experimental therapeutics 20060201
Isoflurane tolerance against focal cerebral ischemia is attenuated by adenosine A1 receptor antagonists. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20060201
Contractile effects of adenosine A1 and A2A receptors in isolated murine hearts. American journal of physiology. Heart and circulatory physiology 20060101
Endogenous adenosine protects preconditioned heart during early minutes of reperfusion by activating Akt. American journal of physiology. Heart and circulatory physiology 20060101
Involvement of adenosine in the effect of fluoxetine on isolated guinea-pig atria. Pharmacological research 20060101
The cellular mechanisms by which adenosine evokes release of nitric oxide from rat aortic endothelium. The Journal of physiology 20060101
Hypoxia-induced desensitization and internalization of adenosine A1 receptors in the rat hippocampus. Neuroscience 20060101
Effects of the A 2A adenosine receptor antagonist KW6002 in the nucleus accumbens in vitro and in vivo. Pharmacology, biochemistry, and behavior 20060101
Endogenous signalling system involved in parotid gland adenosine A(1) receptor-amylase release. Acta physiologica (Oxford, England) 20060101
Involvement of peripheral adenosine A2 receptors in adenosine A1 receptor-mediated recovery of respiratory motor function after upper cervical spinal cord hemisection. The journal of spinal cord medicine 20060101
Effect of theophylline and aminophylline on transmitter release at the mammalian neuromuscular junction is not mediated by cAMP. Clinical and experimental pharmacology & physiology 20060101
2-(Benzimidazol-2-yl)quinoxalines: a novel class of selective antagonists at human A(1) and A(3) adenosine receptors designed by 3D database searching. Journal of medicinal chemistry 20051229
1,2,4-Triazolo[1,5-a]quinoxaline as a versatile tool for the design of selective human A3 adenosine receptor antagonists: synthesis, biological evaluation, and molecular modeling studies of 2-(hetero)aryl- and 2-carboxy-substituted derivatives. Journal of medicinal chemistry 20051215
Effects of urea pretreatment on the binding properties of adenosine A1 receptors. British journal of pharmacology 20051201
Adenosine-stimulated atrial natriuretic peptide release through A1 receptor subtype. Hypertension (Dallas, Tex. : 1979) 20051201
Supersensitivity of P2X receptors in cerebrocortical cell cultures after in vitro ischemia. Journal of neurochemistry 20051201
Cortical spreading depression (CSD)-induced tolerance to transient focal cerebral ischemia in halothane anesthetized rats is affected by anesthetic level but not ATP-sensitive potassium channels. Brain research 20051116
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization. Journal of medicinal chemistry 20051103
In vivo co-ordinated interactions between inhibitory systems to control glutamate-mediated hippocampal excitability. Journal of neurochemistry 20051101
Synthesis and evaluation of [11C]FR194921 as a nonxanthine-type PET tracer for adenosine A1 receptors in the brain. Nuclear medicine and biology 20051101
Inhibitory action of L-type Ca2+ current by paeoniflorin, a major constituent of peony root, in NG108-15 neuronal cells. European journal of pharmacology 20051031
Allosteric modulators affect the internalization of human adenosine A1 receptors. European journal of pharmacology 20051017
Astrocytic purinergic signaling coordinates synaptic networks. Science (New York, N.Y.) 20051007
Blockade of adenosine and dopamine receptors inhibits the development of rapid tolerance to ethanol in mice. Psychopharmacology 20051001
A novel A1 adenosine receptor antagonist, L-97-1 [3-[2-(4-aminophenyl)-ethyl]-8-benzyl-7-{2-ethyl-(2-hydroxy-ethyl)-amino]-ethyl}-1-propyl-3,7-dihydro-purine-2,6-dione], reduces allergic responses to house dust mite in an allergic rabbit model of asthma. The Journal of pharmacology and experimental therapeutics 20051001
Neuroprotective effect of paeoniflorin on cerebral ischemic rat by activating adenosine A1 receptor in a manner different from its classical agonists. British journal of pharmacology 20051001
Adenosine down-regulates giant depolarizing potentials in the developing rat hippocampus by exerting a negative control on glutamatergic inputs. Journal of neurophysiology 20051001
Blood pressure-dependent inhibition of Renin secretion requires A1 adenosine receptors. Hypertension (Dallas, Tex. : 1979) 20051001
Cell-signaling evidence for adenosine stimulation of coronary smooth muscle proliferation via the A1 adenosine receptor. Circulation research 20050916
Persistent upregulation of mu-opioid, but not adenosine, receptors in brains of long-term withdrawn escalating dose 'binge' cocaine-treated rats. Synapse (New York, N.Y.) 20050901
Adenosine inhibits PDGF-induced growth of human glomerular mesangial cells via A(2B) receptors. Hypertension (Dallas, Tex. : 1979) 20050901
Indirect activation of adenosine A1 receptors in cultured rat hippocampal neurons by volatile anaesthetics. European journal of anaesthesiology 20050901
Isoflurane preconditioning decreases glutamate receptor overactivation-induced Purkinje neuronal injury in rat cerebellar slices. Brain research 20050830
2-(1-Hexyn-1-yl)adenosine-induced intraocular hypertension is mediated via K+ channel opening through adenosine A2A receptor in rabbits. European journal of pharmacology 20050822
Evidence against adenosine analogues being agonists at the growth hormone secretagogue receptor. Biochemical pharmacology 20050815
Distinct molecular phenotype of malignant CD34(+) hematopoietic stem and progenitor cells in chronic myelogenous leukemia. Oncogene 20050811
Long-term depression is not modulated by ATP receptors in the rat CA1 hippocampal region. Neuroscience letters 20050805
A1 adenosine receptor knockout mice exhibit increased mortality, renal dysfunction, and hepatic injury in murine septic peritonitis. American journal of physiology. Renal physiology 20050801
Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y1, P2Y2, and/or P2Y4 receptors in the rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience 20050706
Cerebral oxygenation during postasphyxial seizures in near-term fetal sheep. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20050701
Postconditioning reduces infarct size via adenosine receptor activation by endogenous adenosine. Cardiovascular research 20050701
Antagonistic interaction between adenosine A2A and dopamine D2 receptors modulates the social recognition memory in reserpine-treated rats. Behavioural pharmacology 20050701
Long-term potentiation is impaired in middle-aged rats: regional specificity and reversal by adenosine receptor antagonists. The Journal of neuroscience : the official journal of the Society for Neuroscience 20050622
ATP contributes to the generation of network-driven giant depolarizing potentials in the neonatal rat hippocampus. The Journal of physiology 20050615
Does conversion of ATP to adenosine terminate ATP-stimulated vasopressin release from hypothalamo-neurohypophyseal explants? Brain research 20050614
Rapid tolerance to focal cerebral ischemia in rats is induced by preconditioning with electroacupuncture: window of protection and the role of adenosine. Neuroscience letters 20050601
Requisite roles of A2A receptors, nitric oxide, and KATP channels in retinal arteriolar dilation in response to adenosine. Investigative ophthalmology & visual science 20050601
Adenosine A2A-receptor blockade abolishes the roll-off respiratory response to hypoxia in awake lambs. American journal of physiology. Regulatory, integrative and comparative physiology 20050501
A2B adenosine receptor mediates human chorionic vasoconstriction and signals through arachidonic acid cascade. American journal of physiology. Heart and circulatory physiology 20050501
Luminal adenosine stimulates chloride secretion through A1 receptor in mouse jejunum. American journal of physiology. Gastrointestinal and liver physiology 20050501
In vivo adenosine receptor preconditioning reduces myocardial infarct size via subcellular ERK signaling. American journal of physiology. Heart and circulatory physiology 20050501
Human breast cancer cell line MDA-MB-231 expresses endogenous A2B adenosine receptors mediating a Ca2+ signal. British journal of pharmacology 20050501
Enhanced antinociception by intracerebroventricularly and intrathecally-administered orexin A and B (hypocretin-1 and -2) in mice. Peptides 20050501
Activation of adenosine receptors in the posterior cingulate cortex impairs memory retrieval in the rat. Neurobiology of learning and memory 20050501
Effects of AMP579 and adenosine on L-type Ca2+ current in isolated rat ventricular myocytes. Acta pharmacologica Sinica 20050501
Blockade of adenosine A2A receptors reverses short-term social memory impairments in spontaneously hypertensive rats. Behavioural brain research 20050430
Adenosine A1 receptors modulate the discharge activities of inspiratory and biphasic expiratory neurons in the medial region of Nucleus Retrofacialis of neonatal rat in vitro. Neuroscience letters 20050429
ATP-stimulated ANP release through P1 receptor subtype. Regulatory peptides 20050415
The phosphodiesterase 3 inhibitor cilostamide enhances inotropic responses to glucagon but not to dobutamine in rat ventricular myocardium. European journal of pharmacology 20050411
Pharmacological characterisation of the adenosine receptor mediating increased ion transport in the mouse isolated trachea and the effect of allergen challenge. British journal of pharmacology 20050401
Effects of diadenosine polyphosphates on glomerular volume. British journal of pharmacology 20050401
Mechanism of vasodilation to adenosine in coronary arterioles from patients with heart disease. American journal of physiology. Heart and circulatory physiology 20050401
Adenosine agonist regulation of outward active transport of fluorescein across retinal pigment epithelium in rabbits. Experimental eye research 20050401
Adenosine receptor ligands and dizocilpine-induced antinociception in mice. The International journal of neuroscience 20050401
Involvement of adenosine A2a receptor in intraocular pressure decrease induced by 2-(1-octyn-1-yl)adenosine or 2-(6-cyano-1-hexyn-1-yl)adenosine. Journal of pharmacological sciences 20050401
GABA release modified by adenosine receptors in mouse hippocampal slices under normal and ischemic conditions. Neurochemical research 20050401
A series of ligands displaying a remarkable agonistic-antagonistic profile at the adenosine A1 receptor. Journal of medicinal chemistry 20050324
Development of spin-labeled probes for adenosine receptors. Journal of medicinal chemistry 20050324
Induction of delta-opioid receptor function in the midbrain after chronic morphine treatment. The Journal of neuroscience : the official journal of the Society for Neuroscience 20050323
Modulation of short-term social memory in rats by adenosine A1 and A(2A) receptors. Neuroscience letters 20050316
The role of extracellular adenosine in regulating mossy fiber synaptic plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience 20050316
Adenosine contributes to mu-opioid synaptic inhibition in rat substantia gelatinosa in vitro. Neuroscience letters 20050311
A 'locked-on,' constitutively active mutant of the adenosine A1 receptor. European journal of pharmacology 20050307
Acute adenosine preconditioning is mediated by p38 MAPK activation in discrete subcellular compartments. American journal of physiology. Heart and circulatory physiology 20050301
Role of A1 adenosine receptors in regulation of vascular tone. American journal of physiology. Heart and circulatory physiology 20050301
Adenosine produces nitric oxide and prevents mitochondrial oxidant damage in rat cardiomyocytes. Cardiovascular research 20050301
[Effect of adenosine A1-receptors on the respiratory rhythmical discharge activity in neonatal rat brainstem slice in vitro]. Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20050301
Reversal of neuromuscular effects of adenosine by specific adenosine A1-receptor antagonist in live rats. The International journal of neuroscience 20050301
Scavenging of nitric oxide by an antagonist of adenosine receptors. The Journal of pharmacy and pharmacology 20050301
Adenosine A1 receptors are involved in the modulation of the rhythmical respiration in neonatal rat brainstem slice in vitro. Sheng li xue bao : [Acta physiologica Sinica] 20050225
Metabotropic P2Y purinoceptor-mediated presynaptic and postsynaptic enhancement of cerebellar GABAergic transmission. The Journal of neuroscience : the official journal of the Society for Neuroscience 20050223
First visualization of adenosine A(2A) receptors in the human brain by positron emission tomography with [11C]TMSX. Synapse (New York, N.Y.) 20050201
Co-localization and functional interaction between adenosine A(2A) and metabotropic group 5 receptors in glutamatergic nerve terminals of the rat striatum. Journal of neurochemistry 20050201
Increased nociceptive response in mice lacking the adenosine A1 receptor. Pain 20050201
Modulating effect of adenosine deaminase on function of adenosine A1 receptors. Acta pharmacologica Sinica 20050201
Effects of adenosine agonist R-phenylisopropyl-adenosine on halothane anesthesia and antinociception in rats. Acta pharmacologica Sinica 20050201
Morphine can enhance the antiallodynic effect of intrathecal R-PIA in rats with nerve ligation injury. Anesthesia and analgesia 20050201
Adenosine postsynaptically modulates supraoptic neuronal excitability. Journal of neurophysiology 20050101
Stimulation of the proximal tubule Na+-ATPase activity by adenosine A(2A) receptor. The international journal of biochemistry & cell biology 20050101
Inhibition of phenylephrine-induced cardiomyocyte hypertrophy by activation of multiple adenosine receptor subtypes. The Journal of pharmacology and experimental therapeutics 20050101
Adenosine A1 receptors and the anticonvulsant potential of drugs effective in the model of 3-nitropropionic acid-induced seizures in mice. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20050101
Protective effect of adenosine and purine nucleos(t)ides against the death by hydrogen peroxide and glucose deprivation in rat primary astrocytes. Neuroscience research 20050101
Participation of adenosine system in the ketamine-induced motor activity in mice. Pharmacological reports : PR 20050101
S-nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner. BMC cell biology 20050101
Decreased adenosine receptor binding in dystonic brains of the dt(sz) mutant. Neuroscience 20050101
Long-term effect of convulsive behavior on the density of adenosine A1 and A 2A receptors in the rat cerebral cortex. Epilepsia 20050101
Modulation of seizures and synaptic plasticity by adenosinergic receptors in an experimental model of temporal lobe epilepsy induced by pilocarpine in rats. Epilepsia 20050101
Renal blood flow in sepsis. Critical care (London, England) 20050101
2-Chloro-N6-cyclopentyladenosine enhances the anticonvulsant action of carbamazepine in the mouse maximal electroshock-induced seizure model. Pharmacological reports : PR 20050101
Isolated rat inferior mesenteric artery response to adenosine: possible participation of Na+/K+-ATPase and potassium channels. Pharmacological reports : PR 20050101
Adenosine A1/A2a receptor agonist AMP-579 induces acute and delayed preconditioning against in vivo myocardial stunning. American journal of physiology. Heart and circulatory physiology 20041201
ATP inhibits pump activity of lymph vessels via adenosine A1 receptor-mediated involvement of NO- and ATP-sensitive K+ channels. American journal of physiology. Heart and circulatory physiology 20041201
Inhibitory effects of AMP 579, a novel cardioprotective adenosine A1/A2A receptor agonist, on native IKr and cloned HERG current. Naunyn-Schmiedeberg's archives of pharmacology 20041201
Adenosine A1 receptor blockade mimics caffeine's attenuation of ethanol-induced motor incoordination. Basic & clinical pharmacology & toxicology 20041201
Anti-infarct effect of magnesium is not mediated by adenosine A1 receptors in rat globally ischaemic isolated hearts. Clinical and experimental pharmacology & physiology 20041201
Adenosine receptors involved in modulation of noradrenaline release in isolated rat tail artery. European journal of pharmacology 20041103
Cardiovascular responses to microinjection of ATP into the nucleus tractus solitarii of awake rats. American journal of physiology. Regulatory, integrative and comparative physiology 20041101
Effects of adenosine on optic nerve head circulation in rabbits. Experimental eye research 20041101
Quantitative autoradiography of adenosine receptors and NBTI-sensitive adenosine transporters in the brains of mice deficient in the preproenkephalin gene. Brain research 20041029
The anticonvulsant action of propofol on epileptiform activity in rat hippocampal slices. Anesthesia and analgesia 20041001
Adenosine A1-receptor modulation of glutamate-induced calcium influx in rat retinal ganglion cells. Investigative ophthalmology & visual science 20041001
The in vitro and in vivo pharmacological activity of Boiga dendrophila (mangrove catsnake) venom. Autonomic & autacoid pharmacology 20041001
Allosteric modulation and constitutive activity of fusion proteins between the adenosine A1 receptor and different 351Cys-mutated Gi alpha-subunits. European journal of pharmacology 20040919
Adenosine A1 receptors modulate the anxiolytic-like effect of ethanol in the elevated plus-maze in mice. European journal of pharmacology 20040919
P2X receptor activation elicits transporter-mediated noradrenaline release from rat hippocampal slices. The Journal of pharmacology and experimental therapeutics 20040901
Striatal adenosine A(2A) receptor blockade increases extracellular dopamine release following l-DOPA administration in intact and dopamine-denervated rats. Neuropharmacology 20040901
Adenosine acting via A1 receptors, controls the transition to status epilepticus-like behaviour in an in vitro model of epilepsy. Neuropharmacology 20040901
3-Morpholinylsydnonimine inhibits glutamatergic transmission in rat rostral ventrolateral medulla via peroxynitrite formation and adenosine release. Molecular pharmacology 20040901
P2X2 and P2Y1 immunofluorescence in rat neostriatal medium-spiny projection neurones and cholinergic interneurones is not linked to respective purinergic receptor function. British journal of pharmacology 20040901
Ethanol operant self-administration in rats is regulated by adenosine A2 receptors. Alcoholism, clinical and experimental research 20040901
A guinea pig hippocampal slice model of organophosphate-induced seizure activity. The Journal of pharmacology and experimental therapeutics 20040801
Role of adenosine A1 receptor in the regulation of gastrin release. The Journal of pharmacology and experimental therapeutics 20040801
Long-term potentiation is impaired in rat hippocampal slices that produce spontaneous sharp waves. The Journal of physiology 20040801
Adipocyte lipolysis, hormonal and metabolic changes in ethanol-drinking rats. Journal of animal physiology and animal nutrition 20040801
Regulation by equilibrative nucleoside transporter of adenosine outward currents in adult rat spinal dorsal horn neurons. Brain research bulletin 20040730
Histological protection against ischemia-reperfusion injury by early ischemic preconditioning in rat retina. Brain research 20040723
Changes in purine levels and adenosine receptors in kindled seizures in the rat. Neuroreport 20040719
[3H]OSIP339391, a selective, novel, and high affinity antagonist radioligand for adenosine A2B receptors. Biochemical pharmacology 20040715
Adenosine A1 receptors in contrast media-induced renal dysfunction in the normal rat. European radiology 20040701
1,2,4-triazolo[4,3-a]quinoxalin-1-one moiety as an attractive scaffold to develop new potent and selective human A3 adenosine receptor antagonists: synthesis, pharmacological, and ligand-receptor modeling studies. Journal of medicinal chemistry 20040701
Adenosine A(1) receptor antagonist and mitochondrial ATP-sensitive potassium channel blocker attenuate the tolerance to focal cerebral ischemia in rats. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20040701
Study on affinity profile toward native human and bovine adenosine receptors of a series of 1,8-naphthyridine derivatives. Journal of medicinal chemistry 20040603
Role of adenosine A2A receptor in the regulation of gastric somatostatin release. The Journal of pharmacology and experimental therapeutics 20040501
Presynaptic inhibition of spontaneous acetylcholine release induced by adenosine at the mouse neuromuscular junction. British journal of pharmacology 20040501
Pharmacological manipulations of ATP-dependent potassium channels and adenosine A1 receptors do not impact hippocampal ischemic preconditioning in vivo: evidence in a highly quantitative gerbil model. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20040501
Adenosine suppresses GABAA receptor-mediated responses in rat sacral dorsal commissural neurons. Autonomic neuroscience : basic & clinical 20040430
Injection of adenosine into the renal artery activates spontaneous activity of renal afferent nerve fibers. Sheng li xue bao : [Acta physiologica Sinica] 20040425
Inosine stimulates chemotaxis, Ca2+-transients and actin polymerization in immature human dendritic cells via a pertussis toxin-sensitive mechanism independent of adenosine receptors. Journal of cellular physiology 20040401
[Role of adenosine in intraocular pressure]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20040401
Adenosine A1 receptor distribution in the nucleus tractus solitarii of normotensive and spontaneously hypertensive rats. Journal of neural transmission (Vienna, Austria : 1996) 20040401
Repeated dosing with oral allosteric modulator of adenosine A1 receptor produces tolerance in rats with neuropathic pain. Anesthesiology 20040401
[Relation between adenosine A1 receptor and NMDA receptor on synaptic transmission in dentate gyrus of hippocampus]. Yao xue xue bao = Acta pharmaceutica Sinica 20040401
Periodic orbit analysis reveals subtle effects of atropine on epileptiform activity in the guinea-pig hippocampal slice. Neuroscience letters 20040311
Adenosine A1 receptor agonists block the neuropathological changes in rat retrosplenial cortex after administration of the NMDA receptor antagonist dizocilpine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040301
Comparison of three different A1 adenosine receptor antagonists on infarct size and multiple cycle ischemic preconditioning in anesthetized dogs. The Journal of pharmacology and experimental therapeutics 20040301
Binding of the prototypical adenosine A(2A) receptor agonist CGS 21680 to the cerebral cortex of adenosine A(1) and A(2A) receptor knockout mice. British journal of pharmacology 20040301
Dual effects of adenosine on acetylcholine release from myenteric motoneurons are mediated by junctional facilitatory A(2A) and extrajunctional inhibitory A(1) receptors. British journal of pharmacology 20040301
Effects of 2-alkynyladenosine derivatives on intraocular pressure in rabbits. European journal of pharmacology 20040223
A1 adenosine receptor knockout mice exhibit increased renal injury following ischemia and reperfusion. American journal of physiology. Renal physiology 20040201
Hypothermic preconditioning increases survival of purkinje neurons in rat cerebellar slices after an in vitro simulated ischemia. Anesthesiology 20040201
Characteristics of taurine release induced by free radicals in mouse hippocampal slices. Amino acids 20040201
Down-regulation of rat brain adenosine A1 receptors at the end of pregnancy. Journal of neurochemistry 20040201
Chronic hypoxia up-regulates expression of adenosine A1 receptors in DDT1-MF2 cells. Biochemical pharmacology 20040201
Synthesis and biological evaluation of 2,3,5-substituted [1,2,4]thiadiazoles as allosteric modulators of adenosine receptors. Journal of medicinal chemistry 20040129
Adenosine administration produces an antidepressant-like effect in mice: evidence for the involvement of A1 and A2A receptors. Neuroscience letters 20040123
Overexpression of adenosine kinase in epileptic hippocampus contributes to epileptogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience 20040121
Modulation of A1 adenosine receptor signaling by peroxynitrite. Biochemical pharmacology 20040115
A1 adenosine receptor activation inhibits inflammation, necrosis, and apoptosis after renal ischemia-reperfusion injury in mice. Journal of the American Society of Nephrology : JASN 20040101
A1 and A2A adenosine receptor modulation of alpha 1-adrenoceptor-mediated contractility in human cultured prostatic stromal cells. British journal of pharmacology 20040101
Application of fluorescence correlation spectroscopy to the measurement of agonist binding to a G-protein coupled receptor at the single cell level. Faraday discussions 20040101
Modulation by adenosine of Adelta and C primary-afferent glutamatergic transmission in adult rat substantia gelatinosa neurons. Neuroscience 20040101
Involvement of adenosinergic A1 systems in the occurrence of respiratory perturbations encountered in newborns following an in utero caffeine exposure. a study on brainstem-spinal cord preparations isolated from newborn rats. Neuroscience 20040101
Do adenosine receptors play a role in amitriptyline-induced cardiovascular toxicity in rats? Journal of toxicology. Clinical toxicology 20040101
Adenosine mediates decreased cerebral metabolic rate and increased cerebral blood flow during acute moderate hypoxia in the near-term fetal sheep. The Journal of physiology 20031215
Physiological role for P2X1 receptors in renal microvascular autoregulatory behavior. The Journal of clinical investigation 20031215
Caffeine reduces hypnotic effects of alcohol through adenosine A2A receptor blockade. Neuropharmacology 20031201
Involvement of adenosine A1 receptors in forced walking stress-induced analgesia in mice. Methods and findings in experimental and clinical pharmacology 20031201
Effect of drugs active at adenosine receptors upon chronic stress-induced hyperalgesia in rats. European journal of pharmacology 20031128
Adenosinergic protection of dopaminergic and GABAergic neurons against mitochondrial inhibition through receptors located in the substantia nigra and striatum, respectively. The Journal of neuroscience : the official journal of the Society for Neuroscience 20031126
Functional expression of rat adenosine A1 receptor in the dimorphic zygomycete Mucor circinelloides. Applied microbiology and biotechnology 20031101
Activation of adenosine A1 receptor attenuates cardiac hypertrophy and prevents heart failure in murine left ventricular pressure-overload model. Circulation research 20031017
Subcellular localization of adenosine A(1) receptors in nerve terminals and synapses of the rat hippocampus. Brain research 20031010
Noninvasive remote ischemic preconditioning for global protection of skeletal muscle against infarction. American journal of physiology. Heart and circulatory physiology 20031001
Modulation of GABA release during morphine withdrawal in midbrain neurons in vitro. Neuropharmacology 20031001
Evaluation of 18F-CPFPX, a novel adenosine A1 receptor ligand: in vitro autoradiography and high-resolution small animal PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20031001
Adenosine protects against angiotensin II-induced apoptosis in rat cardiocyte cultures. Molecular and cellular biochemistry 20031001
A1 adenosine receptors accumulate in neurodegenerative structures in Alzheimer disease and mediate both amyloid precursor protein processing and tau phosphorylation and translocation. Brain pathology (Zurich, Switzerland) 20031001
Hypersensitivity of pulmonary C fibers induced by adenosine in anesthetized rats. Journal of applied physiology (Bethesda, Md. : 1985) 20030901
Renal effects of adenosine A1-receptor blockade with 8-cyclopentyl-1,3-dipropylxanthine in hypoxemic newborn rabbits. Pediatric research 20030901
Convergent control of synaptic GABA release from rat dorsal horn neurones by adenosine and GABA autoreceptors. The Journal of physiology 20030901
Key neuroprotective role for endogenous adenosine A1 receptor activation during asphyxia in the fetal sheep. Stroke 20030901
Ectonucleotidases of the rabbit ciliary body nonpigmented epithelium. Investigative ophthalmology & visual science 20030901
Brief, repeated, oxygen-glucose deprivation episodes protect neurotransmission from a longer ischemic episode in the in vitro hippocampus: role of adenosine receptors. British journal of pharmacology 20030901
Potential of an adenosine A2A receptor antagonist [11C]TMSX for myocardial imaging by positron emission tomography: a first human study. Annals of nuclear medicine 20030901
Effects of adenosine receptor antagonists on pial arteriolar dilation during carbon dioxide inhalation. European journal of pharmacology 20030829
Antagonist pharmacology of adenosine A2B receptors from rat, guinea pig and dog. European journal of pharmacology 20030815
Diadenosine-5-phosphate exerts A1-receptor-mediated proarrhythmic effects in rabbit atrial myocardium. British journal of pharmacology 20030801
Comparison of effects of MgCl2 and Gpp(NH)p on antagonist and agonist radioligand binding to adenosine A1 receptors. Acta pharmacologica Sinica 20030801
Enhanced adenosine A2A receptor facilitation of synaptic transmission in the hippocampus of aged rats. Journal of neurophysiology 20030801
Decrease of adenosine A1 receptor density and of adenosine neuromodulation in the hippocampus of kindled rats. The European journal of neuroscience 20030801
Adenosine and opioid receptor-mediated cardioprotection in the rat: evidence for cross-talk between receptors. American journal of physiology. Heart and circulatory physiology 20030701
Involvement of adenosine A1 and A2A receptors in the motor effects of caffeine after its acute and chronic administration. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030701
Mechanisms of sevoflurane-induced myocardial preconditioning in isolated human right atria in vitro. Anesthesiology 20030701
A1-receptor blockade: a novel approach for assessing myocardial viability in chronic ischemic cardiomyopathy. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 20030701
Endogenous adenosine reduces glutamatergic output from rods through activation of A2-like adenosine receptors. Journal of neurophysiology 20030701
Partial adenosine A(1) receptor agonists inhibit sarin-induced epileptiform activity in the hippocampal slice. European journal of pharmacology 20030620
Adenosine-mediated synaptic depression and EPSP/spike dissociation following high potassium-induced depolarization in rat hippocampal slices. Brain research 20030613
Intraspinal adenosine induces spinal cord norepinephrine release in spinal nerve-ligated rats but not in normal or sham controls. Anesthesiology 20030601
Analysis of adenosine vascular effect in isolated rat aorta: possible role of Na+/K+-ATPase. Pharmacology & toxicology 20030601
Homo- and heteroexchange of adenine nucleotides and nucleosides in rat hippocampal slices by the nucleoside transport system. British journal of pharmacology 20030601
Caffeine analogs: effects on ryanodine-sensitive calcium-release channels and GABAA receptors. Cellular and molecular neurobiology 20030601
Free radicals potentiate the negative dromotropic effect of adenosine in guinea pig isolated heart. Acta cardiologica 20030601
[Effect of adenosine A1 receptor antagonist on learning and memory and analysis of its mechanism]. Yao xue xue bao = Acta pharmaceutica Sinica 20030601
Species comparison of adenosine A1 receptors in isolated mammalian atrial and ventricular myocardium. Life sciences 20030509
Adenosine receptors mediate glutamate-evoked arteriolar dilation in the rat cerebral cortex. American journal of physiology. Heart and circulatory physiology 20030501
Adenosine A1 receptor activation reduces myocardial reperfusion effects on intrinsic cardiac nervous system. American journal of physiology. Regulatory, integrative and comparative physiology 20030501
Adenosine A2A receptor-mediated facilitation of noradrenaline release involves protein kinase C activation and attenuation of presynaptic inhibitory receptor-mediated effects in the rat vas deferens. Journal of neurochemistry 20030501
Control of glutamatergic neurotransmission in the rat spinal dorsal horn by the nucleoside transporter ENT1. The Journal of physiology 20030415
Dialysis delivery of an adenosine A1 receptor agonist to the pontine reticular formation decreases acetylcholine release and increases anesthesia recovery time. Anesthesiology 20030401
Opposing facilitatory and inhibitory modulation of glutamate release elicited by cAMP production in cerebrocortical nerve terminals (synaptosomes). Neuropharmacology 20030401
Stimulatory effect of paeoniflorin on adenosine release to increase the glucose uptake into white adipocytes of Wistar rat. Planta medica 20030401
A2A and A3 receptors mediate the adenosine-induced relaxation in spontaneously active possum duodenum in vitro. British journal of pharmacology 20030401
Adenosine type 1 (A1) receptors mediate protection against myocardial infarction produced by chronic, intermittent ingestion of ethanol in dogs. International journal of cardiology 20030401
Extracellular ATP-induced calcium channel inhibition mediated by P1/P2Y purinoceptors in hamster submandibular ganglion neurons. British journal of pharmacology 20030401
Involvement of Rho-kinase in P2Y-receptor-mediated contraction of renal glomeruli. Biochemical and biophysical research communications 20030321
Adenosine promotes neuronal recovery from reactive oxygen species induced lesion in rat hippocampal slices. Neuroscience letters 20030320
The volatile anesthetic isoflurane suppresses spontaneous calcium oscillations in vitro in rat hippocampal neurons by activation of adenosine A1 receptors. Neuroscience letters 20030306
Adenosine inhibits N-type calcium channels at the rat neuromuscular junction. Clinical and experimental pharmacology & physiology 20030301
Adenosine A1 receptor-mediated presynaptic inhibition of GABAergic transmission in immature rat hippocampal CA1 neurons. Journal of neurophysiology 20030301
Responsiveness of renal glomeruli to adenosine in streptozotocin-induced diabetic rats dependent on hyperglycaemia level. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20030301
Differential allosteric modulation by amiloride analogues of agonist and antagonist binding at A(1) and A(3) adenosine receptors. Biochemical pharmacology 20030215
Pharmacological analysis of calcium responses mediated by the human A3 adenosine receptor in monocyte-derived dendritic cells and recombinant cells. Molecular pharmacology 20030201
Protein phosphatases mediate depotentiation induced by high-intensity theta-burst stimulation. Journal of neurophysiology 20030201
Regional differences in the adenosine A(2) receptor-mediated modulation of contractions in rat vas deferens. European journal of pharmacology 20030124
Adenosine A1 receptors regulate the response of the mouse circadian clock to light. Brain research 20030117
Does nitric oxide allow endothelial cells to sense hypoxia and mediate hypoxic vasodilatation? In vivo and in vitro studies. The Journal of physiology 20030115
P2Y(1) receptor activation inhibits NMDA receptor-channels in layer V pyramidal neurons of the rat prefrontal and parietal cortex. Neurochemistry international 20030101
Adenosine A1 receptor blockade reverses experimental postoperative ileus in rat colon. European journal of pharmacology 20030101
Adenosine receptor subtypes mediating coronary vasodilation in rat hearts. Journal of cardiovascular pharmacology 20030101
Activity-dependent release of adenosine contributes to short-term depression at CA3-CA1 synapses in rat hippocampus. Journal of neurophysiology 20030101
Presynaptic inhibition of synaptic transmission by adenosine in rat subthalamic nucleus in vitro. Neuroscience 20030101
The roles of nitric oxide in dilating proximal and terminal arterioles of skeletal muscle during systemic hypoxia. Journal of vascular research 20030101
Cross-talk among noradrenaline, adenosine and protein kinase C in the mechanisms of ischemic preconditioning in rabbits. Journal of cardiovascular pharmacology 20030101
Adenosine suppresses the response of neurons to gaba in the superficial laminae of the rat spinal dorsal horn. Neuroscience 20030101
Activation of A(3) receptors by endogenous adenosine inhibits synaptic transmission during hypoxia in rat cortical neurons. Restorative neurology and neuroscience 20030101
Purinergic P2 receptors trigger adenosine release leading to adenosine A2A receptor activation and facilitation of long-term potentiation in rat hippocampal slices. Neuroscience 20030101
Depression of fast excitatory synaptic transmission in large aspiny neurons of the neostriatum after transient forebrain ischemia. The Journal of neuroscience : the official journal of the Society for Neuroscience 20021215
Broad spectrum anticonvulsant activity of BW534U87: possible role of an adenosine-dependent mechanism. Pharmacology, biochemistry, and behavior 20021201
Basolateral and apical A1 adenosine receptors mediate sodium transport in cultured renal epithelial (A6) cells. American journal of physiology. Renal physiology 20021201
Microinjection of an adenosine A1 agonist into the medial pontine reticular formation increases tail flick latency to thermal stimulation. Anesthesiology 20021201
Preconditioning: myocardial function and energetics during coronary hypoperfusion and reperfusion. The Annals of thoracic surgery 20021201
Synthesis and evaluation of no-carrier-added 8-cyclopentyl-3-(3-[(18)F]fluoropropyl)-1-propylxanthine ([(18)F]CPFPX): a potent and selective A(1)-adenosine receptor antagonist for in vivo imaging. Journal of medicinal chemistry 20021107
New irreversible adenosine A(1) antagonists based on FSCPX. Bioorganic & medicinal chemistry letters 20021104
Transducing system operated by adenosine A(2A) receptors to facilitate acetylcholine release in the rat hippocampus. European journal of pharmacology 20021101
Synthesis, molecular modeling studies, and pharmacological activity of selective A(1) receptor antagonists. Journal of medicinal chemistry 20021024
Characterization of the cAMP binding site of purified S-adenosyl-homocysteine hydrolase from bovine kidney. Biochemical pharmacology 20021015
Administration of adenosine receptor agonists or antagonists after controlled cortical impact in mice: effects on function and histopathology. Brain research 20021004
Actions of specific adenosine receptor A1 and A2 agonists and antagonists in recovery of phrenic motor output following upper cervical spinal cord injury in adult rats. Clinical and experimental pharmacology & physiology 20021001
Modulation of hippocampal glutamatergic transmission by ATP is dependent on adenosine a(1) receptors. The Journal of pharmacology and experimental therapeutics 20021001
Correction of G551D-CFTR transport defect in epithelial monolayers by genistein but not by CPX or MPB-07. British journal of pharmacology 20021001
Lignans isolated from valerian: identification and characterization of a new olivil derivative with partial agonistic activity at A(1) adenosine receptors. Journal of natural products 20021001
Presynaptic adenosine A1 receptors regulate retinohypothalamic neurotransmission in the hamster suprachiasmatic nucleus. Journal of neurobiology 20020905
Glucose-induced islet blood flow increase in rats: interaction between nervous and metabolic mediators. American journal of physiology. Endocrinology and metabolism 20020901
Mouse cerebellar adenosine-glutamate interactions and modulation of ethanol-induced motor incoordination. Alcoholism, clinical and experimental research 20020901
Autocrine activation of adenosine A1 receptors blocks D1A but not D1B dopamine receptor desensitization. Journal of neurochemistry 20020901
Effects of A(1) and A(2A) adenosine receptor ligands in mouse acute models of pain. Neuroscience letters 20020816
Differential effects of caffeine on dopamine and acetylcholine transmission in brain areas of drug-naive and caffeine-pretreated rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20020801
Relaxation of the mouse isolated aorta and carotid artery in response to adenosine analogues in genetically-modified mice lacking the adenosine A(2A) receptor. Naunyn-Schmiedeberg's archives of pharmacology 20020801
Adenosine A1 receptor down-regulation in mothers and fetal brain after caffeine and theophylline treatments to pregnant rats. Journal of neurochemistry 20020801
Naturally occurring cembranes from an Australian sarcophyton species. Journal of natural products 20020801
Characterization of adenosine receptors mediating the vasodilator effects of adenosine receptor agonists in the microvasculature of the hamster cheek pouch in vivo. Autonomic & autacoid pharmacology 20020801
Coronary function and adenosine receptor-mediated responses in ischemic-reperfused mouse heart. Cardiovascular research 20020701
Selective allosteric enhancement of agonist binding and function at human A3 adenosine receptors by a series of imidazoquinoline derivatives. Molecular pharmacology 20020701
Adenosine and purine nucleosides protect rat primary astrocytes from peroxynitrite-potentiated, glucose deprivation-induced death: preservation of intracellular ATP level. Experimental neurology 20020701
Mechanisms of desflurane-induced preconditioning in isolated human right atria in vitro. Anesthesiology 20020701
Protein kinase C isoforms and A1 adenosine receptors in porcine coronary smooth muscle cells. Vascular pharmacology 20020701
Role of adenine nucleotides in insulin secretion from MIN6 pseudoislets. Molecular and cellular endocrinology 20020614
Adenosine A1 receptor agonists inhibit trigeminovascular nociceptive transmission. Brain : a journal of neurology 20020601
Effects of adenosine A1 and A2A receptor activation on the evoked release of glutamate from rat cerebrocortical synaptosomes. British journal of pharmacology 20020601
Synergistic up-regulation of vascular endothelial growth factor expression in murine macrophages by adenosine A(2A) receptor agonists and endotoxin. The American journal of pathology 20020601
3-isobutyl-1-methylxanthine (IBMX) sensitizes cardiac myocytes to anoxia. Biochemical pharmacology 20020601
Effect of purinergic agonists and antagonists on insulin secretion from INS-1 cells (insulinoma cell line) and rat pancreatic islets. Canadian journal of physiology and pharmacology 20020601
Role of adenosine receptors in spinal G-protein activation after peripheral nerve injury. Anesthesiology 20020601
Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions. Journal of medicinal chemistry 20020523
Cisplatin up-regulates the adenosine A(1) receptor in the rat kidney. European journal of pharmacology 20020510
Interaction of angiotensin II and adenosine A1 and A2A receptor ligands on the writhing test in mice. Pharmacology, biochemistry, and behavior 20020501
Neuroprotective effects of hyperthermic preconditioning on infarcted volume after middle cerebral artery occlusion in rats: role of adenosine receptors. Critical care medicine 20020501
Spinal noradrenergic activation mediates allodynia reduction from an allosteric adenosine modulator in a rat model of neuropathic pain. Pain 20020501
Adenosine inhibits calcium channel currents via A1 receptors on salamander retinal ganglion cells in a mini-slice preparation. Journal of neurochemistry 20020501
Study of an adenosine A1 receptor agonist on trigeminally evoked dural blood vessel dilation in the anaesthetized rat. Cephalalgia : an international journal of headache 20020501
5'-Deoxy congeners of 9-(3-amido-3-deoxy-beta-D-xylofuranosyl)-N(6)-cyclopentyladenine: new adenosine A(1) receptor antagonists and inverse agonists. Journal of medicinal chemistry 20020425
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. The Journal of biological chemistry 20020419
Adenosine acting on A1 receptors protects NO-triggered rebound potentiation and LTP in rat hippocampal slices. Journal of neurophysiology 20020401
Adenosine A(2A) receptors mediate hypoxic inhibition of fetal breathing in sheep. American journal of obstetrics and gynecology 20020401
The putative roles of adenosine in insulin- and exercise-mediated regulation of glucose transport and glycogen metabolism in skeletal muscle. Canadian journal of applied physiology = Revue canadienne de physiologie appliquee 20020401
1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists. Journal of medicinal chemistry 20020328
PDE7A is expressed in human B-lymphocytes and is up-regulated by elevation of intracellular cAMP. Cellular signalling 20020301
Blockade of adenosine A1 receptors in the posterior cingulate cortex facilitates memory in rats. European journal of pharmacology 20020222
Differential desensitization of responses mediated by presynaptic and postsynaptic A1 adenosine receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience 20020215
Phasic and tonic attenuation of EPSPs by inward rectifier K+ channels in rat hippocampal pyramidal cells. The Journal of physiology 20020215
Diverse inhibitors of intracellular signalling act as adenosine receptor antagonists. Cellular signalling 20020201
A phase I randomized, multicenter trial of CPX in adult subjects with mild cystic fibrosis. Pediatric pulmonology 20020201
Use of nasal potential difference and sweat chloride as outcome measures in multicenter clinical trials in subjects with cystic fibrosis. Pediatric pulmonology 20020201
Pharmacological protection of synaptic function, spatial learning, and memory from transient hypoxia in rats. The Journal of pharmacology and experimental therapeutics 20020201
Apparent activation of cardiovascular A1 adenosine receptors by A3 agonists. American journal of physiology. Heart and circulatory physiology 20020201
Rapid tolerance to focal cerebral ischemia in rats is attenuated by adenosine A1 receptor antagonist. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20020201
A(2B) adenosine receptors stimulate growth of porcine and rat arterial endothelial cells. Hypertension (Dallas, Tex. : 1979) 20020201
Effects of A(3) adenosine receptor activation and gene knock-out in ischemic-reperfused mouse heart. Cardiovascular research 20020101
Intrathecal adenosine following spinal nerve ligation in rat: short residence time in cerebrospinal fluid and no change in A(1) receptor binding. Anesthesiology 20020101
Adenosine A(2A) receptor facilitation of hippocampal synaptic transmission is dependent on tonic A(1) receptor inhibition. Neuroscience 20020101
Lipopolysaccharide binds to and activates A(1) adenosine receptors on human pulmonary artery endothelial cells. Journal of endotoxin research 20020101
Adenosine A1 receptors control dopamine D1-dependent [(3)H]GABA release in slices of substantia nigra pars reticulata and motor behavior in the rat. Neuroscience 20020101
Molecular modeling the human A1 adenosine receptor and study of the mechanisms of its selective ligand binding. Doklady. Biochemistry and biophysics 20020101
Modulatory effect of adenosine receptors on the ascending and descending neural reflex responses of rat ileum. BMC neuroscience 20020101
Mechanisms of delayed preconditioning with A1 adenosine receptor activation in porcine coronary smooth muscle cells. Polish journal of pharmacology 20020101
Regulation of K(+) current in human airway epithelial cells by exogenous and autocrine adenosine. American journal of physiology. Cell physiology 20011201
Adenosine modulates Mg(2+) uptake in distal convoluted tubule cells via A(1) and A(2) purinoceptors. American journal of physiology. Renal physiology 20011201
Antagonism of adenosine A(1) receptors in the NTS does not affect the chemoreflex in awake rats. American journal of physiology. Regulatory, integrative and comparative physiology 20011201
Distinct myoprotective roles of cardiac sarcolemmal and mitochondrial KATP channels during metabolic inhibition and recovery. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20011201
Adenosine inhibits excitatory transmission to substantia gelatinosa neurons of the adult rat spinal cord through the activation of presynaptic A(1) adenosine receptor. Pain 20011201
Depression of excitatory cortico-nucleus accumbens synaptic transmission in rat brain slices by dopamine, but not adenosine, depends upon intracortical mechanisms. Experimental brain research 20011201
Minoxidil-induced hair growth is mediated by adenosine in cultured dermal papilla cells: possible involvement of sulfonylurea receptor 2B as a target of minoxidil. The Journal of investigative dermatology 20011201
Solubilisation and immunoprecipitation of rat striatal adenosine A(2A) receptors. European journal of pharmacology 20011116
Acute and chronic caffeine administration differentially alters striatal gene expression in wild-type and adenosine A(2A) receptor-deficient mice. Synapse (New York, N.Y.) 20011101
Cell-based assay for high-throughput quantitative screening of CFTR chloride transport agonists. American journal of physiology. Cell physiology 20011101
Modulation of N-type Ca2+ currents by A1-adenosine receptor activation in male rat pelvic ganglion neurons. The Journal of pharmacology and experimental therapeutics 20011101
Activation of synaptic NMDA receptors by action potential-dependent release of transmitter during hypoxia impairs recovery of synaptic transmission on reoxygenation. The Journal of neuroscience : the official journal of the Society for Neuroscience 20011101
Mechanism of intracellular calcium ([Ca2+]i) inhibition of lipolysis in human adipocytes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20011101
Effect of adenosine receptor blockade on pial arteriolar dilation during sciatic nerve stimulation. American journal of physiology. Heart and circulatory physiology 20011101
Oxygen delivery and oxygen consumption in rat hindlimb during systemic hypoxia: role of adenosine. The Journal of physiology 20011101
Pharmacological and biochemical characterization of adenosine receptors in the human malignant melanoma A375 cell line. British journal of pharmacology 20011101
A novel analgesic compound OT-7100 attenuates nociceptive responses in animal models of inflammatory and neuropathic hyperalgesia: a possible involvement of adenosinergic anti-nociception. Japanese journal of pharmacology 20011101
Neuronal mechanisms of the anoxia-induced network oscillations in the rat hippocampus in vitro. The Journal of physiology 20011015
Adenosine-mediated hypotension in in vivo guinea-pig: receptors involved and role of NO. British journal of pharmacology 20011001
Role of adenosine in renal protection induced by a brief episode of ischemic preconditioning in rats. Japanese journal of pharmacology 20011001
Different activation mechanisms of cystic fibrosis transmembrane conductance regulator expressed in Xenopus laevis oocytes. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20011001
Smooth muscle does not have a common P2x receptor phenotype: expression, ontogeny and function of P2x1 receptors in mouse ileum, bladder and reproductive systems. Autonomic neuroscience : basic & clinical 20010917
Effects of angiotensin III and angiotensin IV on pentylenetetrazol seizure susceptibility (threshold and kindling): interaction with adenosine A(1) receptors. Brain research bulletin 20010915
Amp 579 reduces contracture and limits infarction in rabbit heart by activating adenosine A2 receptors. Journal of cardiovascular pharmacology 20010901
Adenosine linking reduced O2 to arteriolar NO release in intestine is not formed from extracellular ATP. American journal of physiology. Heart and circulatory physiology 20010901
Adenosine-mediated inhibition of striatal GABAergic synaptic transmission during in vitro ischaemia. Brain : a journal of neurology 20010901
The plasma protein extravasation induced by adenosine and its analogues in the rat dorsal skin: evidence for the involvement of capsaicin sensitive primary afferent neurones and mast cells. British journal of pharmacology 20010901
Pharmacological and biochemical characterization of A3 adenosine receptors in Jurkat T cells. British journal of pharmacology 20010901
Inhibitory effect of ischemic preconditioning on leukocyte participation in retinal ischemia-reperfusion injury. Investigative ophthalmology & visual science 20010901
Systemic adenosine given after ischemia protects renal function via A(2a) adenosine receptor activation. American journal of kidney diseases : the official journal of the National Kidney Foundation 20010901
Effects of adenosine receptor agonists and antagonists in a genetic animal model of primary paroxysmal dystonia. British journal of pharmacology 20010901
Adenosine inhibits glutamate exocytosis largely without interfering with Ca2+ influx in rat cerebrocortical synaptosomes. Neuroscience letters 20010831
Adenosine A(1) receptor agonism in the immature rat brain and heart. European journal of pharmacology 20010831
Adenosine A1 receptors reduce release from excitatory but not inhibitory synaptic inputs onto lateral horn neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 20010815
Adenosine receptor antagonists cancelled the ischemic tolerance phenomenon in gerbil. Brain research 20010810
Adenosine A3 agonist cardioprotection in isolated rat and rabbit hearts is blocked by the A1 antagonist DPCPX. American journal of physiology. Heart and circulatory physiology 20010801
Isoflurane-induced protection against myocardial stunning is independent of adenosine 1 (A(1)) receptor in isolated rat heart. British journal of anaesthesia 20010801
Allosteric adenosine modulation to reduce allodynia. Anesthesiology 20010801
Control of the proinflammatory state in cystic fibrosis lung epithelial cells by genes from the TNF-alphaR/NFkappaB pathway. Molecular medicine (Cambridge, Mass.) 20010801
AMP-activated protein kinase is highly expressed in neurons in the developing rat brain and promotes neuronal survival following glucose deprivation. Journal of molecular neuroscience : MN 20010801
Withdrawal and bidirectional cross-withdrawal responses in rats treated with adenosine agonists and morphine. Life sciences 20010706
Adenosine A(1) and A(2A) receptors modulate sleep state and breathing in fetal sheep. Journal of applied physiology (Bethesda, Md. : 1985) 20010701
Modulation of ethanol-induced motor incoordination by mouse striatal A(1) adenosinergic receptor. Brain research bulletin 20010701
Involvement of the cerebellar adenosine A(1) receptor in cannabinoid-induced motor incoordination in the acute and tolerant state in mice. Brain research 20010629
Agonist-stimulated [35S]GTPgammaS autoradiography: optimization for high sensitivity. European journal of pharmacology 20010622
Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy. Proceedings of the National Academy of Sciences of the United States of America 20010619
Poly(lactic acid) microspheres for the sustained release of a selective A1 receptor agonist. Journal of controlled release : official journal of the Controlled Release Society 20010615
Adenosine A(1) receptor-mediated inhibition of protein kinase A-induced calcitonin gene-related peptide release from rat trigeminal neurons. Molecular pharmacology 20010601
Inhibition of calcium channels by opioid- and adenosine-receptor agonists in neurons of the nucleus accumbens. British journal of pharmacology 20010601
Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience 20010515
Anti-adrenergic effect of adenosine on Na(+)-Ca(2+) exchange current recorded from guinea-pig ventricular myocytes. Cell calcium 20010501
Receptor subtypes mediating adenosine-induced dilation of cerebral arterioles. American journal of physiology. Heart and circulatory physiology 20010501
Determination of amino acid residues that are accessible from the ligand binding crevice in the seventh transmembrane-spanning region of the human A(1) adenosine receptor. Molecular pharmacology 20010501
Age-dependent decrease in adenosine A1 receptor binding sites in the rat brain. Effect of cis unsaturated free fatty acids. European journal of biochemistry 20010501
Ameliorative effects of paeoniflorin, a major constituent of peony root, on adenosine A1 receptor-mediated impairment of passive avoidance performance and long-term potentiation in the hippocampus. Biological & pharmaceutical bulletin 20010501
Electrically evoked release of glutamate in rat hippocampal slices: effects of various drugs and fimbria-fornix lesions. Naunyn-Schmiedeberg's archives of pharmacology 20010501
A functional role for adenosine A3 receptors: modulation of synaptic plasticity in the rat hippocampus. Neuroscience letters 20010413
Dissociation between synaptic depression and block of long-term depression induced by raising the temperature in rat hippocampal slices. Synapse (New York, N.Y.) 20010401
Effect of an adenosine A(1) receptor agonist and a novel pyrimidoindole on membrane properties and neurotransmitter release in rat cortical and hippocampal neurons. Neurochemistry international 20010401
A depletable pool of adenosine in area CA1 of the rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience 20010401
[(35)S]GTPgammaS autoradiography reveals a wide distribution of G(i/o)-linked ADP receptors in the nervous system: close similarities with the platelet P2Y(ADP) receptor. Journal of neurochemistry 20010401
2-chloro-N(6)-cyclopentyladenosine-elicited attenuation of evoked glutamate release is not sufficient to give complete protection against pilocarpine-induced seizures in rats. Neuropharmacology 20010401
Subchronic treatment with methamphetamine and phencyclidine differentially alters the adenosine A1 and A2A receptors in the prefrontal cortex, hippocampus, and striatum of the rat. Neurochemical research 20010401
Adenosine enhances neuroexcitability by inhibiting a slow postspike afterhyperpolarization in rabbit vagal afferent neurons. Circulation 20010306
Adenosine receptor-adenylate cyclase system in the trout testis: involvement in the regulation of germ cell proliferation. Molecular reproduction and development 20010301
Adenosine inhibits norepinephrine release in the postischemic rat heart: the mechanism of neuronal stunning. Cardiovascular research 20010301
Relaxation of mouse isolated aorta to adenosine and its analogues does not involve adenosine A(1), A(2) or A(3) receptors. European journal of pharmacology 20010301
Adenosine A1 receptors regulate the response of the hamster circadian clock to light. European journal of pharmacology 20010223
Regulation of p42/p44 MAPK and p38 MAPK by the adenosine A(1) receptor in DDT(1)MF-2 cells. European journal of pharmacology 20010216
Distinct modulation of evoked and spontaneous EPSCs by purinoceptors in the nucleus tractus solitarii of the rat. The Journal of physiology 20010201
Adenosine-enhanced ischemic preconditioning: adenosine receptor involvement during ischemia and reperfusion. American journal of physiology. Heart and circulatory physiology 20010201
Regulation of G protein-coupled receptor-adenylyl cyclase responsiveness in human airway smooth muscle by exogenous and autocrine adenosine. American journal of respiratory cell and molecular biology 20010201
Müller cell Ca2+ waves evoked by purinergic receptor agonists in slices of rat retina. Journal of neurophysiology 20010201
A1 adenosine receptors inhibit multiple voltage-gated Ca2+ channel subtypes in acutely isolated rat basolateral amygdala neurons. British journal of pharmacology 20010201
G protein activation in rat ponto-mesencephalic nuclei is enhanced by combined treatment with a mu opioid and an adenosine A1 receptor agonist. Sleep 20010201
A(2b) receptors mediate the antimitogenic effects of adenosine in cardiac fibroblasts. Hypertension (Dallas, Tex. : 1979) 20010201
Activation of presynaptic A1-receptors by endogenous adenosine inhibits acetylcholine release in the guinea-pig ileum. Journal of autonomic pharmacology 20010201
3-Aryl[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: a new class of selective A1 adenosine receptor antagonists. Journal of medicinal chemistry 20010201
K(ATP) channel blockers selectively interact with A(1)-adenosine receptor mediated modulation of acetylcholine release in the rat hippocampus. Brain research 20010119
Adenosine A(1) and A(3) receptors mediate inhibition of synaptic transmission in rat cortical neurons. Neuropharmacology 20010101
Pharmacological treatment of the ion transport defect in cystic fibrosis. Expert opinion on investigational drugs 20010101
Adenosine A(2A) receptors mediate cardiovascular responses to hypoxia in fetal sheep. American journal of physiology. Heart and circulatory physiology 20010101
Adenosine A1 receptor activation reduces reactive oxygen species and attenuates stunning in ventricular myocytes. Journal of molecular and cellular cardiology 20010101
Extracellular adenosine modulates a volume-sensitive-like chloride conductance in immortalized rabbit DC1 cells. American journal of physiology. Renal physiology 20010101
Adenosine activates aromatic L-amino acid decarboxylase activity in the kidney and increases dopamine. Journal of the American Society of Nephrology : JASN 20010101
Characterization of prejunctional purinoceptors inhibiting noradrenaline release in rat mesenteric arteries. Japanese journal of pharmacology 20010101
Cardioprotective effects of adenosine A1 and A3 receptor activation during hypoxia in isolated rat cardiac myocytes. Molecular and cellular biochemistry 20010101
Reduced PO(2) and adenosine formation preserve arteriolar nitric oxide synthesis during sympathetic constriction in the rat intestine. Journal of vascular research 20010101
Adenosine preferentially suppresses serotonin2A receptor-enhanced excitatory postsynaptic currents in layer V neurons of the rat medial prefrontal cortex. Neuroscience 20010101
The sulphydryl reagent, N-ethylmaleimide, disrupts sleep and blocks A1 adenosine receptor-mediated inhibition of intracellular calcium signaling in the in vitro ventromedial preoptic nucleus. Neuroscience 20010101
Pharmacology of airway afferent nerve activity. Respiratory research 20010101
[Comparative characteristics of A1-receptor agonists as neuroprotective agents]. Eksperimental'naia i klinicheskaia farmakologiia 20010101
The CFTR-mediated protein secretion defect: pharmacological correction. Pflugers Archiv : European journal of physiology 20010101
Adenosine inhibits IL-12 and TNF-[alpha] production via adenosine A2a receptor-dependent and independent mechanisms. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20001001
Inducible nitric oxide synthase mediates delayed myocardial protection induced by activation of adenosine A(1) receptors: evidence from gene-knockout mice. Circulation 20000822
Cerebellar CB(1) receptor mediation of Delta(9)-THC-induced motor incoordination and its potentiation by ethanol and modulation by the cerebellar adenosinergic A(1) receptor in the mouse. Brain research 20000512
[(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors. Molecular pharmacology 20000501
A1 adenosine receptor activation increases adipocyte leptin secretion. Endocrinology 20000401
Differential expression of renal adenosine A(1) receptors induced by acute renal failure. Biochemical pharmacology 20000315
N-cycloalkyl derivatives of adenosine and 1-deazaadenosine as agonists and partial agonists of the A(1) adenosine receptor. Journal of medicinal chemistry 20000127
Estradiol inhibits smooth muscle cell growth in part by activating the cAMP-adenosine pathway. Hypertension (Dallas, Tex. : 1979) 20000101
Binding of [3H]MSX-2 (3-(3-hydroxypropyl)-7-methyl-8-(m-methoxystyryl)-1-propargylxanthine) to rat striatal membranes--a new, selective antagonist radioligand for A(2A) adenosine receptors. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20000101
Paeoniflorin reverses guanethidine-induced hypotension via activation of central adenosine A1 receptors in Wistar rats. Clinical and experimental pharmacology & physiology 19991001
Epileptogenic action of caffeine during anoxia in the neonatal rat hippocampus. Annals of neurology 19990701
Identification of the adenine binding site of the human A1 adenosine receptor. The Journal of biological chemistry 19990205
Differences in the order of potency for agonists but not antagonists at human and rat adenosine A2A receptors. Biochemical pharmacology 19990101
Comparison of CGS 15943, ZM 241385 and SCH 58261 as antagonists at human adenosine receptors. Naunyn-Schmiedeberg's archives of pharmacology 19990101
Thermodynamics of full agonist, partial agonist, and antagonist binding to wild-type and mutant adenosine A1 receptors. Biochemical pharmacology 19981201
A novel class of adenosine A3 receptor ligands. 1. 3-(2-Pyridinyl)isoquinoline derivatives. Journal of medicinal chemistry 19981008
Decreased presynaptic sensitivity to adenosine after cocaine withdrawal. The Journal of neuroscience : the official journal of the Society for Neuroscience 19981001
Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells. Naunyn-Schmiedeberg's archives of pharmacology 19980101
Canine mast cell adenosine receptors: cloning and expression of the A3 receptor and evidence that degranulation is mediated by the A2B receptor. Molecular pharmacology 19971101
Evidence against a major role of adenosine in oxygen-dependent regulation of erythropoietin in rats. Kidney international 19970801
Adenosine A2 receptors modulate haloperidol-induced catalepsy in rats. European journal of pharmacology 19970611
Synthesis and biological evaluation of the enantiomers of the potent and selective A1-adenosine antagonist 1,3-dipropyl-8-[2-(5,6-epoxynorbonyl)]-xanthine. Journal of medicinal chemistry 19970606
Characterization of human A2A adenosine receptors with the antagonist radioligand [3H]-SCH 58261. British journal of pharmacology 19970501
Role of the second extracellular loop of adenosine receptors in agonist and antagonist binding. Analysis of chimeric A1/A3 adenosine receptors. The Journal of biological chemistry 19941007
Coupling of a transfected human brain A1 adenosine receptor in CHO-K1 cells to calcium mobilisation via a pertussis toxin-sensitive mechanism. British journal of pharmacology 19940401
Molecular cloning and characterization of the human A3 adenosine receptor. Proceedings of the National Academy of Sciences of the United States of America 19931101
Anticonvulsant doses of 2-chloro-N6-cyclopentyladenosine, an adenosine A1 receptor agonist, reduce GABAergic transmission in different areas of the mouse brain. The Journal of pharmacology and experimental therapeutics 19931101
Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. Journal of medicinal chemistry 19930820
Adenosine A1 receptors in human hippocampus: inhibition of [3H]8-cyclopentyl-1,3-dipropylxanthine binding by antagonist drugs. Neuroscience letters 19930219
Comparison of A1 adenosine receptors in brain from different species by radioligand binding and photoaffinity labelling. Naunyn-Schmiedeberg's archives of pharmacology 19910201
Allosteric enhancement of adenosine A1 receptor binding and function by 2-amino-3-benzoylthiophenes. Molecular pharmacology 19901201

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