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101910-24-1

101910-24-1 | Benzenemethanol, α-pentyl-3-(2-quinolinylmethoxy)-

CAS No: 101910-24-1 Catalog No: AG0005X0 MDL No:

Product Description

Catalog Number:
AG0005X0
Chemical Name:
Benzenemethanol, α-pentyl-3-(2-quinolinylmethoxy)-
CAS Number:
101910-24-1
Molecular Formula:
C22H25NO2
Molecular Weight:
335.4394
IUPAC Name:
1-[3-(quinolin-2-ylmethoxy)phenyl]hexan-1-ol
InChI:
InChI=1S/C22H25NO2/c1-2-3-4-12-22(24)18-9-7-10-20(15-18)25-16-19-14-13-17-8-5-6-11-21(17)23-19/h5-11,13-15,22,24H,2-4,12,16H2,1H3
InChI Key:
JRLOEMCOOZSCQP-UHFFFAOYSA-N
SMILES:
CCCCCC(c1cccc(c1)OCc1ccc2c(n1)cccc2)O

Properties

Complexity:
375  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
335.189g/mol
Formal Charge:
0
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
335.447g/mol
Monoisotopic Mass:
335.189g/mol
Rotatable Bond Count:
8  
Topological Polar Surface Area:
42.4A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
XLogP3:
5.2  

Literature

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Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters 20101101
4-Hydroxynonenal enhances MMP-9 production in murine macrophages via 5-lipoxygenase-mediated activation of ERK and p38 MAPK. Toxicology and applied pharmacology 20100115
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nature chemical biology 20091001
Overexpression of 5-lipoxygenase in colon polyps and cancer and the effect of 5-LOX inhibitors in vitro and in a murine model. Clinical cancer research : an official journal of the American Association for Cancer Research 20081015
Mechanism of leukotriene D4 inhibition of Na-alanine cotransport in intestinal epithelial cells. American journal of physiology. Gastrointestinal and liver physiology 20080701
Control of chondrocyte regulatory volume decrease (RVD) by [Ca2+]i and cell shape. Osteoarthritis and cartilage 20080301
The role of arachidonic acid and its metabolites in insulin secretion from human islets of langerhans. Diabetes 20070101
Simultaneous inhibition of COX-2 and 5-LOX activities augments growth arrest and death of premalignant and malignant human lung cell lines. Journal of experimental therapeutics & oncology 20070101
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
5-Lipoxygenase, a marker for early pancreatic intraepithelial neoplastic lesions. Cancer research 20050715
Stimulation of regulatory volume decrease (RVD) by isolated bovine articular chondrocytes following F-actin disruption using latrunculin B. Biorheology 20050101
Inverse agonist activity of selected ligands of the cysteinyl-leukotriene receptor 1. The Journal of pharmacology and experimental therapeutics 20040401
Toxicity of human monocytic THP-1 cells and microglia toward SH-SY5Y neuroblastoma cells is reduced by inhibitors of 5-lipoxygenase and its activating protein FLAP. Journal of leukocyte biology 20030301
Inhibition by eicosapentaenoic acid of IL-1beta-induced PGHS-2 expression in human microvascular endothelial cells: involvement of lipoxygenase-derived metabolites and p38 MAPK pathway. Biochimica et biophysica acta 20030220
Actions of cysteinyl leukotrienes in the enteric nervous system of guinea-pig stomach and small intestine. European journal of pharmacology 20030110
Lipoxygenase inhibitors attenuate growth of human pancreatic cancer xenografts and induce apoptosis through the mitochondrial pathway. Molecular cancer therapeutics 20020901
Enhanced activity of Ca2+-activated K+ channels by 1-[2-hydroxy-3-propyl-4-[(1H-tetrazol-5-yl)butoxyl]phenyl] ethanone (LY-171883) in neuroendocrine and neuroblastoma cell lines. Journal of cellular physiology 20020801
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. The Journal of biological chemistry 20020419
Early vascular permeability in murine experimental peritonitis is co-mediated by resident peritoneal macrophages and mast cells: crucial involvement of macrophage-derived cysteinyl-leukotrienes. Inflammation 20020401
The role of a swelling-activated taurine transport pathway in the regulation of articular chondrocyte volume. Pflugers Archiv : European journal of physiology 20010801
Regulatory volume decrease (RVD) by isolated and in situ bovine articular chondrocytes. Journal of cellular physiology 20010601
Cyclo-oxygenase and lipoxygenase pathways in mast cell dependent-neurogenic inflammation induced by electrical stimulation of the rat saphenous nerve. British journal of pharmacology 20010401
Novel effects of 5,8,11-eicosatriynoic acid, a lipoxygenase inhibitor, on Ca2+ mobilization in Madin Darby canine kidney cells. Pharmacology & toxicology 20010101
Pharmacological investigation of the role of leukotrienes in the pathogenesis of experimental NSAID gastropathy. Inflammation 19920601

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