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Home > Quinoline > 101467-40-7
101467-40-7 | 6-Isoquinolinol, 1,2,3,4-tetrahydro-7-methoxy-1-methyl-, (1R)-
CAS No: 101467-40-7 Catalog No: AG0004JP MDL No:
Product Description
Catalog Number:
AG0004JP
Chemical Name:
6-Isoquinolinol, 1,2,3,4-tetrahydro-7-methoxy-1-methyl-, (1R)-
CAS Number:
101467-40-7
Molecular Formula:
C11H15NO2
Molecular Weight:
193.2423
IUPAC Name:
(1S)-7-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-6-ol
InChI:
InChI=1S/C11H15NO2/c1-7-9-6-11(14-2)10(13)5-8(9)3-4-12-7/h5-7,12-13H,3-4H2,1-2H3/t7-/m0/s1
InChI Key:
YTPRLBGPGZHUPD-ZETCQYMHSA-N
SMILES:
COc1cc2[C@@H](C)NCCc2cc1O
EC Number:
201-897-3
UNII:
T246JT0V8K
Properties
Complexity:
198
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
1
Defined Bond Stereocenter Count:
0
Exact Mass:
193.11g/mol
Formal Charge:
0
Heavy Atom Count:
14
Hydrogen Bond Acceptor Count:
3
Hydrogen Bond Donor Count:
2
Isotope Atom Count:
0
Molecular Weight:
193.246g/mol
Monoisotopic Mass:
193.11g/mol
Rotatable Bond Count:
1
Topological Polar Surface Area:
41.5A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.3
Literature
| Title | Journal |
|---|---|
| Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. | Bioorganic & medicinal chemistry 20121115 |
| Toxic effects of low alcohol and nicotine combinations in SH-SY5Y cells are apoptotically mediated. | Neurotoxicity research 20111001 |
| Chiral capillary electrophoresis-mass spectrometry of tetrahydroisoquinoline-derived neurotoxins: observation of complex stereoisomerism. | Journal of chromatography. A 20110520 |
| Additive protective effects of donepezil and nicotine against salsolinol-induced cytotoxicity in SH-SY5Y cells. | Neurotoxicity research 20091001 |
| A new microdialysis-electrochemical device for in vivo simultaneous determination of acetylcholine and choline in rat brain treated with N-methyl-(R)-salsolinol. | Biosensors & bioelectronics 20090815 |
| Quantification of salsolinol enantiomers by stable isotope dilution liquid chromatography with tandem mass spectrometric detection. | Rapid communications in mass spectrometry : RCM 20081201 |
| Iron contributes to the formation of catechol isoquinolines and oxidative toxicity induced by overdose dopamine in dopaminergic SH-SY5Y cells. | Neuroscience bulletin 20080601 |
| N-Propargylamine protects SH-SY5Y cells from apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, through stabilization of mitochondrial membrane and induction of anti-apoptotic Bcl-2. | Journal of neural transmission (Vienna, Austria : 1996) 20060101 |
| Type A monoamine oxidase is the target of an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol, leading to apoptosis in SH-SY5Y cells. | Journal of neurochemistry 20060101 |
| Involvement of type A monoamine oxidase in neurodegeneration: regulation of mitochondrial signaling leading to cell death or neuroprotection. | Journal of neural transmission. Supplementum 20060101 |
| Neuroprotective function of R-(-)-1-(benzofuran-2-yl)-2-propylaminopentane, [R-(-)-BPAP], against apoptosis induced by N-methyl(R)salsolinol, an endogenous dopaminergic neurotoxin, in human dopaminergic neuroblastoma SH-SY5Y cells. | Life sciences 20040521 |
| Liquid chromatography with amperometric detection at a nano crystalline Ce-doped lead dioxide film modified electrode for determination of (R)-Salsolinol, (R)-N-methylsalsolinol and monoamine neurotransmitters in Parkinsonian patients' cerebrospinal fluid. | The Analyst 20040301 |
| Cell death in Parkinson's disease. | Journal of neurology 20020901 |
| Mitochondrial permeability transition mediates apoptosis induced by N-methyl(R)salsolinol, an endogenous neurotoxin, and is inhibited by Bcl-2 and rasagiline, N-propargyl-1(R)-aminoindan. | Journal of neurochemistry 20020801 |
| Mitochondria determine the survival and death in apoptosis by an endogenous neurotoxin, N-methyl(R)salsolinol, and neuroprotection by propargylamines. | Journal of neural transmission (Vienna, Austria : 1996) 20020501 |
| Dopamine-derived endogenous N-methyl-(R)-salsolinol: its role in Parkinson's disease. | Neurotoxicology and teratology 20020101 |
| Future of neuroprotection in Parkinson's disease. | Parkinsonism & related disorders 20011001 |
| Transfection-enforced Bcl-2 overexpression and an anti-Parkinson drug, rasagiline, prevent nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase induced by an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol. | Journal of neurochemistry 20010801 |
| [Pathogenesis of idiopathic Parkinson's disease]. | Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 20010701 |
| Enantio-specific induction of apoptosis by an endogenous neurotoxin, N-methyl(R)salsolinol, in dopaminergic SH-SY5Y cells: suppression of apoptosis by N-(2-heptyl)-N-methylpropargylamine. | Journal of neural transmission (Vienna, Austria : 1996) 20010101 |
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