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Home > Indoles and Oxindole > 101246-66-6
CAS No: 101246-66-6 Catalog No: AG00041U MDL No:
Title | Journal |
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Posiphen as a candidate drug to lower CSF amyloid precursor protein, amyloid-β peptide and τ levels: target engagement, tolerability and pharmacokinetics in humans. | Journal of neurology, neurosurgery, and psychiatry 20120901 |
Acetylcholinesterase deficiency contributes to neuromuscular junction dysfunction in type 1 diabetic neuropathy. | American journal of physiology. Endocrinology and metabolism 20120815 |
Synthesis of phenserine analogues and evaluation of their cholinesterase inhibitory activities. | Bioorganic & medicinal chemistry 20120815 |
Synthesis of (+)-phenserine using an interrupted Fischer indolization reaction. | The Journal of organic chemistry 20120106 |
Acetylcholinesterase inhibition ameliorates deficits in motivational drive. | Behavioral and brain functions : BBF 20120101 |
Lithium, phenserine, memantine and pioglitazone reverse memory deficit and restore phospho-GSK3β decreased in hippocampus in intracerebroventricular streptozotocin induced memory deficit model. | Brain research 20111202 |
Molybdenum-catalyzed asymmetric allylic alkylation of 3-alkyloxindoles: reaction development and applications. | Chemistry (Weinheim an der Bergstrasse, Germany) 20110301 |
Cholinesterase inhibitors improve both memory and complex learning in aged beagle dogs. | Journal of Alzheimer's disease : JAD 20110101 |
Novel carbamates as orally active acetylcholinesterase inhibitors found to improve scopolamine-induced cognition impairment: pharmacophore-based virtual screening, synthesis, and pharmacology. | Journal of medicinal chemistry 20100909 |
Synthesis of physostigmine analogues and evaluation of their anticholinesterase activities. | Bioorganic & medicinal chemistry letters 20100301 |
Phenserine efficacy in Alzheimer's disease. | Journal of Alzheimer's disease : JAD 20100101 |
Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors. | Bioorganic & medicinal chemistry letters 20091201 |
The perils of Alzheimer's drug development. | Current Alzheimer research 20090201 |
Accommodation of physostigmine and its analogues by acetylcholinesterase is dominated by hydrophobic interactions. | The Biochemical journal 20090101 |
How to approach Alzheimer's disease therapy using stem cell technologies. | Journal of Alzheimer's disease : JAD 20081001 |
Effect of phenserine treatment on brain functional activity and amyloid in Alzheimer's disease. | Annals of neurology 20080501 |
Phenserine. | Expert opinion on investigational drugs 20070701 |
Preclinical investigation of the topical administration of phenserine: transdermal flux, cholinesterase inhibition, and cognitive efficacy. | The Journal of pharmacology and experimental therapeutics 20070401 |
Total synthesis of (+/-) -phenserine via [4+1] cyclization of a bis(alkylthio)carbene and an indole isocyanate. | Organic letters 20070329 |
The experimental Alzheimer's disease drug posiphen [(+)-phenserine] lowers amyloid-beta peptide levels in cell culture and mice. | The Journal of pharmacology and experimental therapeutics 20070101 |
Differential effects of two hexahydropyrroloindole carbamate-based anticholinesterase drugs on the amyloid beta protein pathway involved in Alzheimer's disease. | Neuromolecular medicine 20070101 |
Kinetics of human serum butyrylcholinesterase and its inhibition by a novel experimental Alzheimer therapeutic, bisnorcymserine. | Journal of Alzheimer's disease : JAD 20060901 |
Identification of novel small molecule inhibitors of amyloid precursor protein synthesis as a route to lower Alzheimer's disease amyloid-beta peptide. | The Journal of pharmacology and experimental therapeutics 20060801 |
Palladium-catalyzed enantioselective C-3 allylation of 3-substituted-1H-indoles using trialkylboranes. | Journal of the American Chemical Society 20060517 |
Novel cholinesterase inhibitors as future effective drugs for the treatment of Alzheimer's disease. | Expert opinion on investigational drugs 20060101 |
Anticholinesterase and pharmacokinetic profile of phenserine in healthy elderly human subjects. | Current Alzheimer research 20051001 |
An overview of phenserine tartrate, a novel acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. | Current Alzheimer research 20050701 |
Phenserine Axonyx. | Current opinion in investigational drugs (London, England : 2000) 20050701 |
Further evidence for the cholinergic hypothesis of aging and dementia from the canine model of aging. | Progress in neuro-psychopharmacology & biological psychiatry 20050301 |
Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine. | Journal of medicinal chemistry 20050224 |
The cholinesterase inhibitor, phenserine, improves Morris water maze performance of scopolamine-treated rats. | Life sciences 20050121 |
The integrated role of desferrioxamine and phenserine targeted to an iron-responsive element in the APP-mRNA 5'-untranslated region. | Annals of the New York Academy of Sciences 20041201 |
Asymmetric synthesis of pyrrolidinoindolines. Application for the practical total synthesis of (-)-phenserine. | Journal of the American Chemical Society 20041103 |
Sensitivity of [11C]N-methylpyrrolidinyl benzilate ([11C]NMPYB) to endogenous acetylcholine: PET imaging vs tissue sampling methods. | Nuclear medicine and biology 20040501 |
(R)-N-[11C]methyl-3-pyrrolidyl benzilate, a high-affinity reversible radioligand for PET studies of the muscarinic acetylcholine receptor. | Synapse (New York, N.Y.) 20020701 |
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
Methyl analogues of the experimental Alzheimer drug phenserine: synthesis and structure/activity relationships for acetyl- and butyrylcholinesterase inhibitory action. | Journal of medicinal chemistry 20011122 |
Acetylcholinesterase inhibition increases in vivo N-(2-[18F]fluoroethyl)-4-piperidyl benzilate binding to muscarinic acetylcholine receptors. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20010201 |
Phenserine (Axonyx/NIH). | IDrugs : the investigational drugs journal 20001001 |
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