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1009298-59-2 | Benzamide, 3-[2,4-bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-N-methyl-
CAS No: 1009298-59-2 Catalog No: AG000382 MDL No:MFCD22628784
Product Description
Catalog Number:
AG000382
Chemical Name:
Benzamide, 3-[2,4-bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-N-methyl-
CAS Number:
1009298-59-2
Molecular Formula:
C25H30N6O3
Molecular Weight:
462.5441
MDL Number:
MFCD22628784
IUPAC Name:
3-[2,4-bis[(3S)-3-methylmorpholin-4-yl]pyrido[2,3-d]pyrimidin-7-yl]-N-methylbenzamide
InChI:
InChI=1S/C25H30N6O3/c1-16-14-33-11-9-30(16)23-20-7-8-21(18-5-4-6-19(13-18)24(32)26-3)27-22(20)28-25(29-23)31-10-12-34-15-17(31)2/h4-8,13,16-17H,9-12,14-15H2,1-3H3,(H,26,32)/t16-,17-/m0/s1
InChI Key:
JUSFANSTBFGBAF-IRXDYDNUSA-N
SMILES:
CNC(=O)c1cccc(c1)c1ccc2c(n1)nc(nc2N1CCOC[C@@H]1C)N1CCOC[C@@H]1C
UNII:
0BSC3P4H5X
Properties
Complexity:
698
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1
Defined Atom Stereocenter Count:
2
Defined Bond Stereocenter Count:
0
Exact Mass:
462.238g/mol
Formal Charge:
0
Heavy Atom Count:
34
Hydrogen Bond Acceptor Count:
8
Hydrogen Bond Donor Count:
1
Isotope Atom Count:
0
Molecular Weight:
462.554g/mol
Monoisotopic Mass:
462.238g/mol
Rotatable Bond Count:
4
Topological Polar Surface Area:
92.7A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.8
Literature
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|---|---|
| Vistusertib (dual m-TORC1/2 inhibitor) in combination with paclitaxel in patients with high-grade serous ovarian and squamous non-small-cell lung cancer. | Annals of oncology : official journal of the European Society for Medical Oncology 20180901 |
| Evaluation of the combination of the dual m-TORC1/2 inhibitor vistusertib (AZD2014) and paclitaxel in ovarian cancer models. | Oncotarget 20171226 |
| mTOR/p70S6K signaling distinguishes routine, maintenance-level autophagy from autophagic cell death during influenza A infection. | Virology 20140301 |
| Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: the discovery of AZD8055 and AZD2014. | Bioorganic & medicinal chemistry letters 20130301 |
| TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. | Cell metabolism 20120502 |
| Mammalian autophagy: core molecular machinery and signaling regulation. | Current opinion in cell biology 20100401 |
| Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. | Nature 20090716 |
| Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. | Current biology : CB 20040727 |
| Regulation of longevity and stress resistance by Sch9 in yeast. | Science (New York, N.Y.) 20010413 |
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