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10040-45-6 | Phenol, 4,4'-(2-pyridinylmethylene)bis-, 1,1'-bis(hydrogen sulfate), sodium salt (1:2)
CAS No: 10040-45-6 Catalog No: AG0001XS MDL No:MFCD00867640
Product Description
Catalog Number:
AG0001XS
Chemical Name:
Phenol, 4,4'-(2-pyridinylmethylene)bis-, 1,1'-bis(hydrogen sulfate), sodium salt (1:2)
CAS Number:
10040-45-6
Molecular Formula:
C18H13NNa2O8S2
Molecular Weight:
481.4073
MDL Number:
MFCD00867640
IUPAC Name:
disodium;[4-[pyridin-2-yl-(4-sulfonatooxyphenyl)methyl]phenyl] sulfate
InChI:
InChI=1S/C18H15NO8S2.2Na/c20-28(21,22)26-15-8-4-13(5-9-15)18(17-3-1-2-12-19-17)14-6-10-16(11-7-14)27-29(23,24)25;;/h1-12,18H,(H,20,21,22)(H,23,24,25);;/q;2*+1/p-2
InChI Key:
GOZDTZWAMGHLDY-UHFFFAOYSA-L
SMILES:
[O-]S(=O)(=O)Oc1ccc(cc1)C(c1ccccn1)c1ccc(cc1)OS(=O)(=O)[O-].[Na+].[Na+]
EC Number:
233-120-9
UNII:
VW106606Y8
Properties
Complexity:
633
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
3
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
480.988g/mol
Formal Charge:
0
Heavy Atom Count:
31
Hydrogen Bond Acceptor Count:
9
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
481.401g/mol
Monoisotopic Mass:
480.988g/mol
Rotatable Bond Count:
5
Topological Polar Surface Area:
163A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
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| Serial monitoring of the physiological effects of the standard Pico-Salax® regimen for colon cleansing in healthy volunteers. | Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20120701 |
| Split-dose picosulfate, magnesium oxide, and citric acid solution markedly enhances colon cleansing before colonoscopy: a randomized, controlled trial. | Gastrointestinal endoscopy 20120301 |
| Laxative management in ambulatory cancer patients on opioid therapy: a prospective, open-label investigation of polyethylene glycol, sodium picosulphate and lactulose. | European journal of cancer care 20120101 |
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| Same day prep for afternoon colonoscopy: everybody wins! | Journal of clinical gastroenterology 20120101 |
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| Bowel preparation regimen for computed tomography colonography. | Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes 20101201 |
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| Multicenter, 4-week, double-blind, randomized, placebo-controlled trial of sodium picosulfate in patients with chronic constipation. | The American journal of gastroenterology 20100401 |
| A possible troponin I leak arising from bowel preparation for elective colonoscopy - are there more implications than observed? | Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 20100301 |
| Pico-Salax versus polyethylene glycol for bowel cleanout before colonoscopy in children: a randomized controlled trial. | Endoscopy 20091201 |
| A multicentre, observational study of sodium picosulfate and magnesium citrate as a precolonoscopy bowel preparation. | Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20091001 |
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| Plasma magnesium should be monitored perioperatively in patients undergoing colorectal resection. | Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 20090701 |
| The rapid development of hyponatraemia and seizures in an elderly patient following sodium picosulfate/magnesium citrate (Picolax). | Age and ageing 20090701 |
| Pico-salax plus two-day bisacodyl is superior to pico-salax alone or oral sodium phosphate for colon cleansing before colonoscopy. | The American journal of gastroenterology 20090301 |
| Sodium picosulfate/magnesium citrate: a review of its use as a colorectal cleanser. | Drugs 20090101 |
| [Optimization of perioperative management in laparoscopic hernioplasty]. | Der Anaesthesist 20080901 |
| A randomized controlled trial comparing the efficacy and acceptability of phospo-soda buffered saline (Fleet) with sodium picosulphate/magnesium citrate (Picoprep) in the preparation of patients for colonoscopy. | Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 20080601 |
| A randomised controlled trial of a new 2 litre polyethylene glycol solution versus sodium picosulphate + magnesium citrate solution for bowel cleansing prior to colonoscopy. | Current medical research and opinion 20080201 |
| OTC laxative use of sodium picosulfate â results of a pharmacy-based patient survey (cohort study). | International journal of clinical pharmacology and therapeutics 20080201 |
| [Treatment with bisacodyl, picosulfate and prokinetics. Physiopathology and diagnosis of constipation]. | Pharmazie in unserer Zeit 20080101 |
| Factors affecting outcomes in colonoscopy. | Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates 20080101 |
| Comparison of colon-cleansing methods in preparation for colonoscopy--comparative efficacy of solutions of mannitol, sodium picosulfate and monobasic and dibasic sodium phosphates. | Acta cirurgica brasileira 20080101 |
| Commonly used bowel preparations have significant and different effects upon cell proliferation in the colon: a pilot study. | BMC gastroenterology 20080101 |
| Interaction between Shaoyao-Gancao-Tang and a laxative with respect to alteration of paeoniflorin metabolism by intestinal bacteria in rats. | Phytomedicine : international journal of phytotherapy and phytopharmacology 20070801 |
| Is patient outcome affected by the administration of intravenous fluid during bowel preparation for colonic surgery? | Annals of the Royal College of Surgeons of England 20070701 |
| Randomised, placebo-controlled, double-blind study to investigate the efficacy and safety of the acute use of sodium picosulphate in patients with chronic constipation. | International journal of clinical practice 20070601 |
| Comparison of bisacodyl and sodium picosulphate in the treatment of chronic constipation. | Current medical research and opinion 20070401 |
| A review of current issues underlying colon cleansing before colonoscopy. | Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20070201 |
| Randomized clinical trial comparing sodium picosulfate with mannitol on the preparation FOR colonoscopy in hospitalized patients. | Arquivos de gastroenterologia 20070101 |
| [Preparation for colonoscopy using 1,000 ml Magcorol P isotonic solution in the absence of dietary restrictions or use of purgatives on the preceding day]. | Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru 20070101 |
| Sodium picosulfate in opioid-induced constipation: results of an open-label, prospective, dose-ranging study. | Palliative medicine 20060601 |
| Which is the optimal bowel preparation for colonoscopy - a meta-analysis. | Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 20060501 |
| Audit of bowel preparation with Picolax (sodium picosulfate plus magnesium citrate) for colonoscopy. | International journal of clinical practice 20060501 |
| An unusual difficulty in bowel preparation for emergency colonoscopy. | Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 20060101 |
| Bioavailability of glycyrrhizin from Shaoyao-Gancao-Tang in laxative-treated rats. | The Journal of pharmacy and pharmacology 20051001 |
| Effects of oral sodium picosulphate Picolax on urea and electrolytes. | Nursing standard (Royal College of Nursing (Great Britain) : 1987) 20050701 |
| Screening procedure for detection of stimulant laxatives and/or their metabolites in human urine using gas chromatography-mass spectrometry after enzymatic cleavage of conjugates and extractive methylation. | Therapeutic drug monitoring 20050401 |
| Randomized single blind trial of two low-volume bowel preparations for screening computed tomographic colonography. | Abdominal imaging 20050101 |
| Psychological well-being and symptoms in women with chronic constipation treated with sodium picosulphate. | Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates 20050101 |
| Retrospective study of long-term treatment with sodium picosulfate. | European journal of gastroenterology & hepatology 20040401 |
| Picoprep-3 is a superior colonoscopy preparation to Fleet: a randomized, controlled trial comparing the two bowel preparations. | Diseases of the colon and rectum 20040201 |
| [Bowel preparation for colonoscopy with sodium picosulphate and magnesium citrate in children and adolescents]. | Arquivos de gastroenterologia 20040101 |
| Optimizing bowel preparation for multidetector row CT colonography: effect of Citramag and Picolax. | Clinical radiology 20030901 |
| [Comparison of the effectiveness and tolerability of the saccharosum-sennosid-B solution and sodium-picosulfate in preparation for colonoscopy. Prospective, multicenter, randomized study]. | Orvosi hetilap 20030810 |
| Randomized clinical trial of intravenous fluid replacement during bowel preparation for surgery. | The British journal of surgery 20011001 |
| Investigation of the effects of YM-31636, a novel 5-HT3 receptor agonist, on defecation in normal and constipated ferrets. | European journal of pharmacology 20010720 |
| Analytical control of a pharmaceutical formulation of sodium picosulfate by capillary zone electrophoresis. | Journal of chromatography. B, Biomedical sciences and applications 20010210 |
| The role of intestinal bacteria in the transformation of sodium picosulfate. | Japanese journal of pharmacology 19920501 |
| Toxicity study with sodium picosulfate in cultured liver cells of rabbit, rat and man. | Arzneimittel-Forschung 19810101 |
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