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100286-97-3 | Propanoic acid, 2-hydroxy-, compd. with 1,6-dihydro-2-methyl-6-oxo[3,4'-bipyridine]-5-carbonitrile (1:?)
CAS No: 100286-97-3 Catalog No: AG0001GV MDL No:MFCD00875852
Product Description
Catalog Number:
AG0001GV
Chemical Name:
Propanoic acid, 2-hydroxy-, compd. with 1,6-dihydro-2-methyl-6-oxo[3,4'-bipyridine]-5-carbonitrile (1:?)
CAS Number:
100286-97-3
Molecular Formula:
C15H15N3O4
Molecular Weight:
301.2973
MDL Number:
MFCD00875852
IUPAC Name:
2-hydroxypropanoic acid;6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile
InChI:
InChI=1S/C12H9N3O.C3H6O3/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8;1-2(4)3(5)6/h2-6H,1H3,(H,15,16);2,4H,1H3,(H,5,6)
InChI Key:
VWUPWEAFIOQCGF-UHFFFAOYSA-N
SMILES:
OC(=O)C(O)C.N#Cc1cc(c2ccncc2)c([nH]c1=O)C
Properties
Complexity:
478
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
301.106g/mol
Formal Charge:
0
Heavy Atom Count:
22
Hydrogen Bond Acceptor Count:
6
Hydrogen Bond Donor Count:
3
Isotope Atom Count:
0
Molecular Weight:
301.302g/mol
Monoisotopic Mass:
301.106g/mol
Rotatable Bond Count:
2
Topological Polar Surface Area:
123A^2
Undefined Atom Stereocenter Count:
1
Undefined Bond Stereocenter Count:
0
Literature
| Title | Journal |
|---|---|
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| A comparison of the effects of digoxin, ouabain and milrinone on naloxone-precipitated withdrawal syndrome in mice. | European journal of pharmacology 20121105 |
| Levosimendan versus milrinone in neonates and infants after corrective open-heart surgery: a pilot study. | Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20120901 |
| Effects of milrinone on left ventricular cardiac function during cooling in an intact animal model. | Cryobiology 20120801 |
| When the heart runs out of heartbeats: treatment options for refractory end-stage heart failure. | Circulation 20120612 |
| Milrinone and homeostasis to treat cerebral vasospasm associated with subarachnoid hemorrhage: the Montreal Neurological Hospital protocol. | Neurocritical care 20120601 |
| Seeking new approaches: milrinone in the treatment of cerebral vasospasm. | Neurocritical care 20120601 |
| A clinical assay for the measurement of milrinone in plasma by HPLC mass spectrometry. | Biomedical chromatography : BMC 20120501 |
| The natriuretic peptides BNP and CNP increase heart rate and electrical conduction by stimulating ionic currents in the sinoatrial node and atrial myocardium following activation of guanylyl cyclase-linked natriuretic peptide receptors. | Journal of molecular and cellular cardiology 20120501 |
| Milrinone is preferred to levosimendan for mesenteric perfusion in hypoxia-reoxygenated newborn piglets treated with dopamine. | Pediatric research 20120301 |
| Neonatal blood pressure support: the use of inotropes, lusitropes, and other vasopressor agents. | Clinics in perinatology 20120301 |
| Milrinone and mortality in adult cardiac surgery: a meta-analysis. | Journal of cardiothoracic and vascular anesthesia 20120201 |
| Zinc depletion causes multiple defects in ovarian function during the periovulatory period in mice. | Endocrinology 20120201 |
| Cardiorenal syndrome. | Heart & lung : the journal of critical care 20120101 |
| Milrinone, a phosphodiesterase III inhibitor, prevents reduction of jugular bulb saturation during rewarming from hypothermic cardiopulmonary bypass. | Perfusion 20120101 |
| Preoperative inhalation of milrinone attenuates inflammation in patients undergoing cardiac surgery with cardiopulmonary bypass. | Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20120101 |
| Preoperative management in patients with single-ventricle physiology. | Congenital heart disease 20120101 |
| Inhibition of phosphoinositide 3-kinase potentiates relaxation of porcine coronary arteries induced by nitroglycerin by decreasing phosphodiesterase type 5 activity. | Circulation journal : official journal of the Japanese Circulation Society 20120101 |
| Hyperglycemia raises the threshold of levosimendan- but not milrinone-induced postconditioning in rat hearts. | Cardiovascular diabetology 20120101 |
| Editorial. | Perfusion 20120101 |
| Pharmacologic interventions to improve splanchnic oxygenation during ventilation with positive end-expiratory pressure. | Advances in experimental medicine and biology 20120101 |
| Heart failure treated with low-dose milrinone in a full-term newborn. | Prague medical report 20120101 |
| Low-dose β-blocker in combination with milrinone safely improves cardiac function and eliminates pulsus alternans in patients with acute decompensated heart failure. | Circulation journal : official journal of the Japanese Circulation Society 20120101 |
| Milrinone treatment of bovine oocytes during in vitro maturation benefits production of nuclear transfer embryos by improving enucleation rate and developmental competence. | The Journal of reproduction and development 20120101 |
| Combination of β-blocker and milrinone for acute heart failure. | Circulation journal : official journal of the Japanese Circulation Society 20120101 |
| Use of milrinone to treat cardiac dysfunction in infants with pulmonary hypertension secondary to congenital diaphragmatic hernia: a review of six patients. | Neonatology 20120101 |
| Judgment often impossible without randomized trials. Commentary on N. Patel: use of milrinone to treat cardiac dysfunction in infants with pulmonary hypertension secondary to congenital diaphragmatic hernia: a review of six patients (Neonatology 2012;102:130-136). | Neonatology 20120101 |
| Vasoactive compounds in the neonatal period. | Current medicinal chemistry 20120101 |
| Prevention for pediatric low cardiac output syndrome: results from the European survey EuLoCOS-Paed. | Paediatric anaesthesia 20111201 |
| Relation of milrinone after surgery for congenital heart disease to significant postoperative tachyarrhythmias. | The American journal of cardiology 20111201 |
| Treatment for paediatric low cardiac output syndrome: results from the European EuLoCOS-Paed survey. | Archives of disease in childhood 20111201 |
| Vassopressors and inotropes. | The Medical letter on drugs and therapeutics 20111114 |
| How mechanical circulatory support helps not to need it--new strategies in pediatric heart failure. | Artificial organs 20111101 |
| Severe acute cardiomyopathy associated with venlafaxine overdose and possible role of CYP2D6 and CYP2C19 polymorphisms. | Clinical toxicology (Philadelphia, Pa.) 20111101 |
| [Levosimendan treatment of severe acute congestive heart failure refractory to dobutamine/milrinone in children]. | Vojnosanitetski pregled 20111101 |
| [Combination therapy; dobutamine and milrinone]. | Nihon rinsho. Japanese journal of clinical medicine 20111101 |
| A liquid chromatography-mass spectrometry method for nicotine and cotinine; utility in screening tobacco exposure in patients taking amiodarone. | Biomedical chromatography : BMC 20111001 |
| Unmasking of neonatal renovascular hypertension by milrinone used for cardiac dysfunction. | Pediatric cardiology 20111001 |
| Age-dependent effects of milrinone and levosimendan on ventricular function and haemodynamics in newborn and mature pigs. | Cardiology in the young 20111001 |
| Newer inotropes in pediatric heart failure. | Journal of cardiovascular pharmacology 20110801 |
| Age exacerbates chronic catecholamine-induced impairments in contractile reserve in the rat. | American journal of physiology. Regulatory, integrative and comparative physiology 20110801 |
| Drug use patterns for the prevention of paediatric low cardiac output syndrome in Europe. | Intensive care medicine 20110801 |
| Pulmonary hypertension in a patient with subarachnoid hemorrhage. | Journal of neurosurgical anesthesiology 20110701 |
| Milrinone attenuates thromboxane receptor-mediated hyperresponsiveness in hypoxic pulmonary arterial myocytes. | British journal of pharmacology 20110701 |
| Synergic bronchodilator effects of a phosphodiesterase 3 inhibitor olprinone with a volatile anaesthetic sevoflurane in ovalbumin-sensitised guinea pigs. | European journal of anaesthesiology 20110701 |
| Is monitoring milrinone therapy useful in advanced heart failure? | International journal of cardiology 20110616 |
| Levosimendan in congenital cardiac surgery: a randomized, double-blind clinical trial. | Journal of cardiothoracic and vascular anesthesia 20110601 |
| Simultaneous delivery of inhaled prostacyclin and milrinone through a double nebulizer system. | Journal of cardiothoracic and vascular anesthesia 20110601 |
| Heart protection by combination therapy with esmolol and milrinone at late-ischemia and early reperfusion. | Cardiovascular drugs and therapy 20110601 |
| Effect of milrinone on ischemia-reperfusion injury in the rat kidney. | Transplantation proceedings 20110601 |
| [Effect of inhaling specific phosphodiesterase inhibitor on lung injury induced by cardiopulmonary bypass]. | Zhonghua yi xue za zhi 20110531 |
| The role of milrinone in children with cardiovascular compromise: review of the literature. | Wiener medizinische Wochenschrift (1946) 20110401 |
| Hospital in the home. | Australian family physician 20110401 |
| Mechanism of cardioprotective effect of adenocine and non-glycoside cardiotonic drugs during experimental chronic cardiac insufficiency. | Bulletin of experimental biology and medicine 20110301 |
| Angiographic evaluation of the effect of intra-arterial milrinone therapy in patients with vasospasm from aneurysmal subarachnoid hemorrhage. | Neuroradiology 20110201 |
| [Anesthetic management for mitral valve replacement in a patient with mitral stenosis and dilated cardiomyopathy]. | Masui. The Japanese journal of anesthesiology 20110201 |
| Rotating inotrope therapy in a pediatric population with decompensated heart failure. | Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20110101 |
| Use of milrinone in the management of haemodynamic instability following duct ligation. | European journal of pediatrics 20110101 |
| Synthesis of 2-(4-substitutedbenzyl-[1,4]diazepan-1-yl)-n-(1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides as inotropic agents. | Chemical biology & drug design 20110101 |
| Pharmacotherapy for acute heart failure syndromes. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20110101 |
| Neurite outgrowth mediated by translation elongation factor eEF1A1: a target for antiplatelet agent cilostazol. | PloS one 20110101 |
| Mouse versus rat: Profound differences in meiotic regulation at the level of the isolated oocyte. | Molecular reproduction and development 20110101 |
| Exposure of human seminal vesicle tissue to phosphodiesterase (PDE) inhibitors antagonizes the contraction induced by norepinephrine and increases production of cyclic nucleotides. | Urology 20101201 |
| Milrinone for persistent pulmonary hypertension of the newborn. | The Cochrane database of systematic reviews 20101110 |
| Neuronal nitric oxide synthase supports Renin release during sodium restriction through inhibition of phosphodiesterase 3. | American journal of hypertension 20101101 |
| Effect of milrinone analogues on intracellular calcium increase in single living H9C2 cardiac cells. | European journal of medicinal chemistry 20101101 |
| Inhaled nitroglycerin versus inhaled milrinone in children with congenital heart disease suffering from pulmonary artery hypertension. | Journal of cardiothoracic and vascular anesthesia 20101001 |
| The function of vascular smooth muscle phosphodiesterase III is preserved in healthy human aging. | Clinical and translational science 20101001 |
| The effects of selective and nonselective phosphodiesterase inhibitors on phagocytic cells in mice. | Immunopharmacology and immunotoxicology 20100901 |
| Prostacyclin and milrinone by aerosolization improve pulmonary hemodynamics in newborn lambs with experimental pulmonary hypertension. | Journal of applied physiology (Bethesda, Md. : 1985) 20100901 |
| Combined usage of inhaled and intravenous milrinone in pulmonary hypertension after heart valve surgery. | Collegium antropologicum 20100901 |
| Use of a hybrid operating room to diagnose and treat delayed coronary spasm after mitral valve repair. | The Journal of thoracic and cardiovascular surgery 20100801 |
| Synthesis of 2-(4-substituted benzyl-1,4-diazepan-1-yl)-N-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-7-yl)acetamides and their positive inotropic evaluation. | Bioorganic & medicinal chemistry letters 20100801 |
| Suppressing apoptosis with milrinone simulating extracorporeal circulation: a pilot study. | The Thoracic and cardiovascular surgeon 20100801 |
| Pharmacological preconditioning by milrinone: memory preserving and neuroprotective effect in ischemia-reperfusion injury in mice. | Archives of pharmacal research 20100701 |
| Central leptin treatment modulates brain glucosensing function and peripheral energy metabolism of rainbow trout. | Peptides 20100601 |
| Milrinone, dobutamine or epinephrine use in asphyxiated newborn pigs resuscitated with 100% oxygen. | Intensive care medicine 20100601 |
| Efficacy of milrinone versus nitroglycerin in controlling pulmonary arterial hypertension induced by intravenous injections of absolute ethanol in anesthetized dogs. | Journal of vascular and interventional radiology : JVIR 20100601 |
| Milrinone improves diastolic function in coronary artery bypass surgery as assessed by acoustic quantification and peak filling rate: a prospective randomized study. | Journal of cardiothoracic and vascular anesthesia 20100401 |
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| Low central venous pressure with milrinone during living donor hepatectomy. | American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20100401 |
| Hemodynamic management and outcome of patients treated for cerebral vasospasm with intraarterial nicardipine and/or milrinone. | Anesthesia and analgesia 20100301 |
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| Rapid assessment and safe management of severe pulmonary hypertension with milrinone during orthotopic liver transplantation. | Clinical transplantation 20100101 |
| Effect of vasodilation by milrinone, a phosphodiesterase III inhibitor, on vasospastic arteries after a subarachnoid hemorrhage in vitro and in vivo: effectiveness of cisternal injection of milrinone. | Neurosurgery 20100101 |
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| Baroreflex sensitivity might predict responders to milrinone in patients with heart failure. | International heart journal 20100101 |
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| Regulation of phosphodiesterase 3 in the pulmonary arteries during the perinatal period in sheep. | Pediatric research 20091201 |
| Perioperative platelet activation and the inhibitory effect of milrinone. | Anesthesiology 20091201 |
| Phosphodiesterase 3 inhibition reduces platelet activation and monocyte tissue factor expression in knee arthroplasty patients. | Anesthesiology 20091201 |
| Influence of temperature on the positive inotropic effect of levosimendan, dobutamine and milrinone. | European journal of anaesthesiology 20091101 |
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| Genistein stimulates electrogenic Cl- secretion via phosphodiesterase modulation in the mouse jejunum. | American journal of physiology. Cell physiology 20090901 |
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| The effect of milrinone on platelet activation as determined by TEG platelet mapping. | Anesthesia and analgesia 20090501 |
| Therapy for acute heart failure syndromes. | Current cardiology reports 20090501 |
| Milrinone and theophylline act as lower oesophageal sphincter relaxing agents: a comparative pharmacodynamic study in the rabbit. | Journal of veterinary pharmacology and therapeutics 20090401 |
| Comparison of inhaled and intravenous milrinone in patients with pulmonary hypertension undergoing mitral valve surgery. | Advances in therapy 20090401 |
| Intestinal hemodynamic effects of milrinone in asphyxiated newborn pigs after reoxygenation with 100% oxygen: a dose-response study. | Shock (Augusta, Ga.) 20090301 |
| High performance liquid chromatography using UV detection for the quantification of milrinone in plasma: improved sensitivity for inhalation. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090301 |
| Developmental changes in the effects of prostaglandin E2 in the chicken ductus arteriosus. | Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20090201 |
| Randomized trial of milrinone versus placebo for prevention of low systemic blood flow in very preterm infants. | The Journal of pediatrics 20090201 |
| Milrinone increases flow in coronary artery bypass grafts after cardiopulmonary bypass: a prospective, randomized, double-blind, placebo-controlled study. | Journal of cardiothoracic and vascular anesthesia 20090201 |
| Milrinone as a rescue therapy for symptomatic refractory cerebral vasospasm in aneurysmal subarachnoid hemorrhage. | Neurocritical care 20090101 |
| Increased cAMP signaling can ameliorate the hypertensive condition in spontaneously hypertensive rats. | Journal of vascular research 20090101 |
| Intra-arterial milrinone for reversible cerebral vasoconstriction syndrome. | Headache 20090101 |
| Inhaled milrinone attenuates experimental acute lung injury. | Intensive care medicine 20090101 |
| Milrinone enhances relaxation to prostacyclin and iloprost in pulmonary arteries isolated from lambs with persistent pulmonary hypertension of the newborn. | Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20090101 |
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| Nebulized phosphodiesterase III inhibitor during warm ischemia attenuates pulmonary ischemia-reperfusion injury. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20090101 |
| Milrinone infusion: a therapeutic option in coronary vasospasm after primary percutaneous transluminal coronary angioplasty. | Annals of cardiac anaesthesia 20090101 |
| To explant or not to explant: an invasive and noninvasive monitoring protocol to determine the need of continued ventricular assist device support. | Congestive heart failure (Greenwich, Conn.) 20090101 |
| Predictors of inotrope use in patients undergoing concomitant coronary artery bypass graft (CABG) and aortic valve replacement (AVR) surgeries at separation from cardiopulmonary bypass (CPB). | Journal of cardiothoracic surgery 20090101 |
| Short term effects of milrinone on biomarkers of necrosis, apoptosis, and inflammation in patients with severe heart failure. | Journal of translational medicine 20090101 |
| Apelin inhibits insulin secretion in pancreatic beta-cells by activation of PI3-kinase-phosphodiesterase 3B. | Endocrine research 20090101 |
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| Correlation between plasma milrinone concentration and renal function in patients with cardiac disease. | Acta anaesthesiologica Scandinavica 20080801 |
| Phosphodiesterase 3 is present in rabbit and human erythrocytes and its inhibition potentiates iloprost-induced increases in cAMP. | American journal of physiology. Heart and circulatory physiology 20080801 |
| Dose-response effects of milrinone on hemodynamics of newborn pigs with hypoxia-reoxygenation. | Intensive care medicine 20080701 |
| Role of phosphodiesterases in modulation of BKCa channels in hypertensive pulmonary arterial smooth muscle. | Therapeutic advances in respiratory disease 20080601 |
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| Evoked changes in cardiovascular function in rats by infusion of levosimendan, OR-1896 [(R)-N-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)acetamide], OR-1855 [(R)-6-(4-aminophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one], dobutamine, and milrinone: comparative effects on peripheral resistance, cardiac output, dP/dt, pulse rate, and blood pressure. | The Journal of pharmacology and experimental therapeutics 20080401 |
| Milrinone for the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage. | Stroke 20080301 |
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| Treating pulmonary hypertension post cardiopulmonary bypass in pigs: milrinone vs. sildenafil analog. | Perfusion 20080301 |
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| Inhaled iloprost to control pulmonary artery hypertension in patients undergoing mitral valve surgery: a prospective, randomized-controlled trial. | Acta anaesthesiologica Scandinavica 20080101 |
| Comparative effects of levosimendan, OR-1896, OR-1855, dobutamine, and milrinone on vascular resistance, indexes of cardiac function, and O2 consumption in dogs. | American journal of physiology. Heart and circulatory physiology 20080101 |
| Combined milrinone and enteral metoprolol therapy in patients with septic myocardial depression. | Critical care (London, England) 20080101 |
| The effects of vasopressor and vasodilator on hemodynamic energy in terms of surplus hemodynamic energy. | ASAIO journal (American Society for Artificial Internal Organs : 1992) 20080101 |
| Nebulized milrinone use in a pulmonary hypertensive crisis. | Pharmacotherapy 20071201 |
| Milrinone does not improve free flap survival in microvascular surgery. | Anaesthesia and intensive care 20071001 |
| Thrombin regulates intracellular cyclic AMP concentration in human platelets through phosphorylation/activation of phosphodiesterase 3A. | Blood 20070901 |
| Effects of milrinone on contractility and cyclic adenosine monophosphate production induced by beta1- and beta2-adrenergic receptor activation in human myocardium. | Clinical therapeutics 20070801 |
| Cardiac resynchronization therapy in patients with end-stage inotrope-dependent class IV heart failure. | The American journal of cardiology 20070701 |
| Milrinone enhances systolic, but not diastolic function during coronary artery bypass grafting surgery. | Canadian journal of anaesthesia = Journal canadien d'anesthesie 20070701 |
| Differential effects of phosphodiesterase PDE-3/PDE-4-specific inhibitors on vasoconstriction and cAMP-dependent vasorelaxation following balloon angioplasty. | American journal of physiology. Heart and circulatory physiology 20070601 |
| Preliminary experience with inhaled milrinone in cardiac surgery. | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20070601 |
| Classical inotropes and new cardiac enhancers. | Heart failure reviews 20070601 |
| Hemolytic-uremic syndrome and myocardial dysfunction in a 9-month-old boy. | Paediatric anaesthesia 20070601 |
| Arterial-wave reflections are increased in heart failure patients with a left-ventricular assist device. | American journal of hypertension 20070601 |
| The effects of vasoactive agents on flow through saphenous vein grafts during lower-extremity peripheral vascular surgery. | Journal of cardiothoracic and vascular anesthesia 20070601 |
| [Efficacy of continuous intraoperative administration of low-dose milrinone during the circumflex artery anastomosis of off-pump coronary artery bypass]. | Masui. The Japanese journal of anesthesiology 20070601 |
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| Population pharmacokinetics and dosing regimen design of milrinone in preterm infants. | Archives of disease in childhood. Fetal and neonatal edition 20070501 |
| Regulation of adiponectin and leptin secretion and expression by insulin through a PI3K-PDE3B dependent mechanism in rat primary adipocytes. | The Biochemical journal 20070501 |
| Levosimendan restores both systolic and diastolic cardiac performance in lipopolysaccharide-treated rabbits: comparison with dobutamine and milrinone. | Critical care medicine 20070501 |
| Home inotropic therapy in children. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20070501 |
| Tolerability of beta-blockers in outpatients with refractory heart failure who were receiving continuous milrinone. | Pharmacotherapy 20070501 |
| Levosimendan in cardiac surgery: a unique drug for the treatment of perioperative left ventricular dysfunction or just another inodilator searching for a clinical application? | Anesthesia and analgesia 20070401 |
| The effects of levosimendan in cardiac surgery patients with poor left ventricular function. | Anesthesia and analgesia 20070401 |
| The cardiovascular effects of adrenaline, dobutamine and milrinone in rabbits using pressure-volume loops and guinea pig isolated atrial tissue. | Anaesthesia and intensive care 20070401 |
| Hydralazine and nitrates: beyond race and ethnicity. | Journal of cardiac failure 20070401 |
| Perioperative nesiritide versus milrinone in high-risk coronary artery bypass graft patients. | The Annals of pharmacotherapy 20070301 |
| Nesiritide compared with milrinone for cardiac surgery. | The Annals of pharmacotherapy 20070301 |
| Renal dysfunction in heart failure patients: what is the evidence? | Heart failure reviews 20070301 |
| Cardiovascular support in the preterm: treatments in search of indications. | The Journal of pediatrics 20070201 |
| Regulation of human internal mammary and radial artery contraction by extracellular and intracellular calcium channels and cyclic adenosine 3', 5' monophosphate. | The Annals of thoracic surgery 20070201 |
| Effects of low-dose milrinone on weaning from cardiopulmonary bypass and after in patients with mitral stenosis and pulmonary hypertension. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20070201 |
| [Intravenous milrinone in the treatment of pediatric heart failure]. | Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20070201 |
| Arginine vasopressin in advanced cardiovascular failure during the post-resuscitation phase after cardiac arrest. | Resuscitation 20070101 |
| Mechanisms of a reduced cardiac output and the effects of milrinone and levosimendan in a model of infant cardiopulmonary bypass. | Critical care medicine 20070101 |
| Effects of phosphodiesterase (PDE) inhibitors on human ether-a-go-go related gene (hERG) channel activity. | Journal of applied toxicology : JAT 20070101 |
| Milrinone combined with vasopressin improves cardiac index after cardiopulmonary resuscitation in a pig model of myocardial infarction. | Anesthesiology 20070101 |
| Inhalation of the phosphodiesterase-3 inhibitor milrinone attenuates pulmonary hypertension in a rat model of congestive heart failure. | Anesthesiology 20070101 |
| Cardiovascular pharmacotherapy update for the intensive care unit. | Critical care nursing quarterly 20070101 |
| Treating metabolic impairment and myocardial stunning with phosphodiesterase inhibitor type III, milrinone, administered prior to coronary artery occlusion in the presence of calcium channel blockade in pigs. | Annals of cardiac anaesthesia 20070101 |
| The metabolic and renal effects of adrenaline and milrinone in patients with myocardial dysfunction after coronary artery bypass grafting. | Critical care (London, England) 20070101 |
| Long-term support with milrinone prior to cardiac transplantation in a neonate with left ventricular noncompaction cardiomyopathy. | Pediatric cardiology 20070101 |
| Effects of 4 classes of cardiovascular drugs on ventricular function in dogs with mitral regurgitation. | Journal of veterinary internal medicine 20070101 |
| Metabolic effects of phosphodiesterase III inhibitors: another reason to promote their use? | Critical care (London, England) 20070101 |
| Pulmonary hypertension due to unknown causes in liver resection. | Journal of anesthesia 20070101 |
| The use of vasoactive therapy for acute decompensated heart failure: hemodynamic and renal considerations. | Reviews in cardiovascular medicine 20070101 |
| Effects of standard heart failure therapy and concomitant treatment with intravenous furosemide or inotropes (dobutamine, dopamine, and/or milrinone) on renal function and mortality in patients treated with nesiritide. | The American journal of cardiology 20061215 |
| Treatment of ischaemic left ventricular dysfunction with milrinone or dobutamine administered during coronary artery stenosis in the presence of beta blockade in pigs. | British journal of anaesthesia 20061201 |
| Dynamic changes of post-ischemic hepatic microcirculation improved by a pre-treatment of phosphodiesterase-3 inhibitor, milrinone. | The Journal of surgical research 20061201 |
| Chronic inotropic therapy in end-stage heart failure. | American heart journal 20061201 |
| Racial differences in the characteristics of patients admitted for acute decompensated heart failure and their relation to outcomes: results from the OPTIME-CHF trial. | Journal of cardiac failure 20061201 |
| Inhaled milrinone: a new alternative in cardiac surgery? | Seminars in cardiothoracic and vascular anesthesia 20061201 |
| Effects of prostacyclin and milrinone on pulmonary hemodynamics in newborn lambs with persistent pulmonary hypertension induced by ductal ligation. | Pediatric research 20061101 |
| Outpatient continuous inotrope infusion as an adjunct to heart failure therapy in Duchenne muscular dystrophy. | Neuromuscular disorders : NMD 20061101 |
| Is vasopressin really superior to norepinephrine in reversing milrinone-induced vasodilation? | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20061001 |
| The effect of milrinone on the right ventricular function in patients with reduced right ventricular function undergoing off-pump coronary artery bypass graft surgery. | Journal of Korean medical science 20061001 |
| Milrinone administered before ischemia or just after reperfusion, attenuates myocardial stunning in anesthetized swine. | Cardiovascular drugs and therapy 20061001 |
| Testing new drugs for heart failure in children. | Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20060901 |
| Proper use of phosphodiesterase inhibitors according to the situations. | Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists 20060901 |
| Abundant transcripts from retrotransposons are unstable in fully grown mouse oocytes. | Biochemical and biophysical research communications 20060818 |
| Effects of milrinone on blood flow of the Y-graft composed with the radial and the internal thoracic artery in patients with coronary artery disease. | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20060801 |
| Outcomes associated with vasoactive therapy in patients with acute decompensated heart failure. | Pharmacotherapy 20060801 |
| Cardiovascular collapse due to massive pulmonary thromboembolism during orthotopic liver transplantation. | Journal of clinical anesthesia 20060801 |
| Effect of cyclodextrin nanocavity confinement on the photorelaxation of the cardiotonic drug milrinone. | The journal of physical chemistry. B 20060727 |
| Flexible versus nonflexible mitral valve rings for congestive heart failure: differential durability of repair. | Circulation 20060704 |
| cGMP stimulates renin secretion in vivo by inhibiting phosphodiesterase-3. | American journal of physiology. Renal physiology 20060601 |
| Comparative hemodynamic effects of vasopressin and norepinephrine after milrinone-induced hypotension in off-pump coronary artery bypass surgical patients. | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20060601 |
| A comparison of three phosphodiesterase type III inhibitors on mechanical and metabolic function in guinea pig isolated hearts. | Anesthesia and analgesia 20060601 |
| Fast relaxation dynamics of the cardiotonic drug milrinone in water solutions. | Journal of medicinal chemistry 20060601 |
| Levosimendan or milrinone in the type 2 diabetic patient with low ejection fraction undergoing elective coronary artery surgery. | Journal of cardiothoracic and vascular anesthesia 20060601 |
| Milrinone improves oxygenation in neonates with severe persistent pulmonary hypertension of the newborn. | Journal of critical care 20060601 |
| Treatment of Persistent Pulmonary Hypertension of the Newborn (PPHN) is in its infancy. | Journal of critical care 20060601 |
| Arterial baroreflex sensitivity is a good predictor of inotropic responses to a phosphodiesterase inhibitor in human heart failure. | Clinical cardiology 20060601 |
| Cardiovascular effects of a phosphodiesterase III inhibitor in the presence of carvedilol in dogs. | The Journal of veterinary medical science 20060601 |
| Effect of levosimendan and milrinone on regional myocardial ischemia/reperfusion-induced arrhythmias in dogs. | Journal of cardiovascular pharmacology and therapeutics 20060601 |
| Biventricular diastolic filling patterns after coronary artery bypass graft surgery. | The Journal of thoracic and cardiovascular surgery 20060501 |
| Activation of the adenylyl cyclase/protein kinase A pathway facilitates neural release of beta-nicotinamide adenine dinucleotide in canine mesenteric artery. | European journal of pharmacology 20060424 |
| Increased systemic inflammation and oxidative stress in patients with worsening congestive heart failure: improvement after short-term inotropic support. | Clinical science (London, England : 1979) 20060401 |
| Population pharmacokinetics of milrinone in neonates with hypoplastic left heart syndrome undergoing stage I reconstruction. | Anesthesia and analgesia 20060401 |
| Phosphodiesterase III inhibition affects platelet-monocyte aggregate formation depending on the axis of stimulation. | Journal of cardiothoracic and vascular anesthesia 20060401 |
| Tirofiban (Aggrastat) protects platelets and decreases platelet-granulocyte binding in an extracorporeal circulation model. | The Thoracic and cardiovascular surgeon 20060401 |
| Community-acquired bacterial meningitis. | The New England journal of medicine 20060330 |
| Treatment with phosphodiesterase inhibitors type III and V: milrinone and sildenafil is an effective combination during thromboxane-induced acute pulmonary hypertension. | British journal of anaesthesia 20060301 |
| Optimizing outcomes in the patient with acute decompensated heart failure. | American heart journal 20060301 |
| Outpatient continuous parenteral inotropic therapy as bridge to transplantation in children with advanced heart failure. | Journal of cardiac failure 20060301 |
| Cardiovascular support in the preterm: treatments in search of indications. | The Journal of pediatrics 20060301 |
| Pilot study of milrinone for low systemic blood flow in very preterm infants. | The Journal of pediatrics 20060301 |
| NT-proBNP as a marker for persistent cardiac disease in children with history of dilated cardiomyopathy and myocarditis. | Pediatric cardiology 20060101 |
| Neonatal persistent pulmonary hypertension treated with milrinone: four case reports. | Biology of the neonate 20060101 |
| Cilostazol, an inhibitor of type 3 phosphodiesterase, produces endothelium-independent vasodilation in pressurized rabbit cerebral penetrating arterioles. | Journal of vascular research 20060101 |
| In vivo dilatation of the fetal and postnatal ductus arteriosus by inhibition of phosphodiesterase 3 in rats. | Biology of the neonate 20060101 |
| The effects of olprinone, a phosphodiesterase 3 inhibitor, on systemic and cerebral circulation. | Current vascular pharmacology 20060101 |
| Effects of milrinone and butyrolactone-I on porcine oocyte meiotic progression and developmental competence. | Reproduction, fertility, and development 20060101 |
| Predictors of clinical outcome in advanced heart failure patients on continuous intravenous milrinone therapy. | ASAIO journal (American Society for Artificial Internal Organs : 1992) 20060101 |
| Effects of a phosphodiesterase 3 inhibitor, olprinone, on rhythmical change in tension of human gastroepiploic artery. | European journal of pharmacology 20051228 |
| Novel milrinone analogs of pyridine-3-carbonitrile derivatives as promising cardiotonic agents. | European journal of medicinal chemistry 20051201 |
| Selective pulmonary vasodilation with inhaled aerosolized milrinone in heart transplant candidates. | Canadian journal of anaesthesia = Journal canadien d'anesthesie 20051201 |
| 3,4-trans-4-Aryl-3-(1-pyridinio)-1,2,3,4-tetrahydropyridine-6-thiolates--new group of potential cardiotonic drugs. | European journal of medicinal chemistry 20051101 |
| Zaprinast attenuates hypoxic pulmonary artery injury and causes less aortic relaxation than milrinone. | Shock (Augusta, Ga.) 20051101 |
| Differential pharmacologic sensitivities of phosphodiesterase-3 inhibitors among human isolated gastroepiploic, internal mammary, and radial arteries. | Anesthesia and analgesia 20051001 |
| Positive inotropic and negative chronotropic effects of proton pump inhibitors in isolated rat atrium. | European journal of pharmacology 20050920 |
| Reassessment of dobutamine, dopamine, and milrinone in the management of acute heart failure syndromes. | The American journal of cardiology 20050919 |
| Pharmacological induction of CFTR function in patients with cystic fibrosis: mutation-specific therapy. | Pediatric pulmonology 20050901 |
| Insights into structure-activity relationships from lipophilicity profiles of pyridin-2(1H)-one analogs of the cardiotonic agent milrinone. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20050901 |
| Reduction in interaction between cGMP and cAMP in dog ventricular myocytes with hypertrophic failure. | American journal of physiology. Heart and circulatory physiology 20050901 |
| Cross-talk between adenosine and the oxatriazole derivative GEA 3175 in platelets. | European journal of pharmacology 20050711 |
| In-hospital mortality in patients with acute decompensated heart failure requiring intravenous vasoactive medications: an analysis from the Acute Decompensated Heart Failure National Registry (ADHERE). | Journal of the American College of Cardiology 20050705 |
| Acute decompensated heart failure: the shrinking role of inotropic therapy. | Journal of the American College of Cardiology 20050705 |
| Hemodynamic changes during off-pump coronary artery bypass anastomosis in patients with coexisting mitral regurgitation: improvement with milrinone. | Anesthesia and analgesia 20050701 |
| Both milrinone and colforsin daropate attenuate the sustained pial arteriolar constriction seen after unclamping of an abdominal aortic cross-clamp in rabbits. | Anesthesia and analgesia 20050701 |
| Inhaled but not intravenous milrinone prevents pulmonary endothelial dysfunction after cardiopulmonary bypass. | The Journal of thoracic and cardiovascular surgery 20050701 |
| Effects of various selective phosphodiesterase inhibitors on carbachol-induced contraction and cyclic nucleotide contents in the guinea pig gall bladder. | The Journal of veterinary medical science 20050701 |
| A sensitive and specific high performance liquid chromatographic assay for milrinone in rat and human plasma using a commercially available internal standard and low sample volume. | Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20050624 |
| Impaired vasoreactivity in end-stage heart failure patients on intravenous inotropic support. | Journal of cardiac failure 20050601 |
| Effects of milrinone versus epinephrine on left ventricular relaxation after cardiopulmonary bypass following myocardial revascularization: assessment by color m-mode and tissue Doppler. | Journal of cardiothoracic and vascular anesthesia 20050601 |
| Levosimendan in cardiac surgery. | Journal of cardiothoracic and vascular anesthesia 20050601 |
| Lower serum sodium is associated with increased short-term mortality in hospitalized patients with worsening heart failure: results from the Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF) study. | Circulation 20050517 |
| Diagnosis and treatment of neonatal hypotension outside the transitional period. | Early human development 20050501 |
| Diagnosis and treatment of preterm transitional circulatory compromise. | Early human development 20050501 |
| Therapeutic efficacy of milrinone in the management of enterovirus 71-induced pulmonary edema. | Pediatric pulmonology 20050301 |
| Effects of neonatal hypoxia in the rat on inotropic stimulation of the adult heart. | Cardiovascular research 20050301 |
| The effects of milrinone on hemodynamics in an experimental septic shock model. | Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20050301 |
| Left ventricular conditioning in the elderly patient to prevent congestive heart failure after transcatheter closure of atrial septal defect. | Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20050301 |
| Effect of milrinone on echocardiographic parameters after single dose in Beagle dogs and relationship with drug-induced cardiotoxicity. | Toxicology letters 20050215 |
| Concomitant use of nesiritide and milrinone in decompensated congestive heart failure. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20050201 |
| Milrinone for pulmonary hypertension: additional benefits, concerns, and caution. | Journal of cardiothoracic and vascular anesthesia 20050201 |
| [A case of continuous infusion of milrinone during continuous venovenous hemofiltration causing high plasma concentration of milrinone]. | Masui. The Japanese journal of anesthesiology 20050201 |
| Reduction of diabetes-induced oxidative stress by phosphodiesterase inhibitors in rats. | Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20050201 |
| Dobutamine versus milrinone after subarachnoid hemorrhage. | Neurosurgery 20050101 |
| Oral sildenafil reduces pulmonary hypertension after cardiac surgery. | The Annals of thoracic surgery 20050101 |
| Application of papillary muscle sling concept in an infant as a biological bridge to transplantation. | The Annals of thoracic surgery 20050101 |
| Greater vasopressin-induced vasoconstriction and inferior effects of nitrovasodilators and milrinone in the radial artery than in the internal thoracic artery. | The Journal of thoracic and cardiovascular surgery 20050101 |
| Levosimendan is superior to milrinone and dobutamine in selectively increasing microvascular gastric mucosal oxygenation in dogs. | Critical care medicine 20050101 |
| Levosimendan and gut mucosal blood flow--not all inotropes are created equal. | Critical care medicine 20050101 |
| Look-alike, sound-alike drugs review: include look-alike packaging as an additional safety check. | Joint Commission journal on quality and patient safety 20050101 |
| Intravenous milrinone infusion improves congestive heart failure caused by diastolic dysfunction: a brief case series. | Texas Heart Institute journal 20050101 |
| Milrinone and low cardiac output following cardiac surgery in infants: is there a direct myocardial effect? | Pediatric cardiology 20050101 |
| Drugs to facilitate recovery of neuromuscular blockade and muscle strength. | Journal of anesthesia 20050101 |
| Increased cost effectiveness with nesiritide vs. milrinone or dobutamine in the treatment of acute decompensated heart failure. | Congestive heart failure (Greenwich, Conn.) 20050101 |
| Risk stratification after hospitalization for decompensated heart failure. | Journal of cardiac failure 20041201 |
| Compatibility of argatroban with selected cardiovascular agents. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20041115 |
| Effects of milrinone on jugular bulb oxygen saturation and cerebrovascular carbon dioxide reactivity in patients undergoing coronary artery bypass graft surgery. | British journal of anaesthesia 20041101 |
| Effect of specific phosphodiesterase isoenzyme inhibitors during in vitro maturation of bovine oocytes on meiotic and developmental capacity. | Biology of reproduction 20041001 |
| Efficacy of pre-emptive milrinone in off-pump coronary artery bypass surgery: comparison between patients with a low and normal pre-graft cardiac index. | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20041001 |
| Effects of a new phosphodiesterase enzyme type V inhibitor (UK 343-664) versus milrinone in a porcine model of acute pulmonary hypertension. | The Annals of thoracic surgery 20041001 |
| Prevention of early sudden circulatory collapse after the Norwood operation. | Circulation 20040914 |
| Milrinone efficiently potentiates insulin secretion induced by orally but not intravenously administered glucose in C57BL6J mice. | European journal of pharmacology 20040913 |
| A prospective study of continuous intravenous milrinone therapy for status IB patients awaiting heart transplant at home. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20040901 |
| Effects of various selective phosphodiesterase inhibitors on carbachol-induced contraction and cyclic nucleotide contents in guinea pig taenia coli. | The Journal of veterinary medical science 20040901 |
| Effects of dopamine, dobutamine, amrinone and milrinone on regional blood flow in isoflurane anesthetized dogs. | The Journal of veterinary medical science 20040901 |
| Synergistic effect on insulin secretion from INS-1 cells of a sulfonylurea and a phosphodiesterase 3 inhibitor. | Life sciences 20040806 |
| Off-pump epicardial tissue sealing--a novel method for atrioventricular disruption complicating mitral valve procedures. | The Annals of thoracic surgery 20040801 |
| Predictors of inotrope use during separation from cardiopulmonary bypass. | Journal of cardiothoracic and vascular anesthesia 20040801 |
| In vitro effects of risperidone and 9-hydroxy-risperidone on human platelet function, plasma coagulation, and fibrinolysis. | Clinical therapeutics 20040801 |
| Milrinone reduces cerebral vasospasm after subarachnoid hemorrhage of WFNS grade IV or V. | Neurologia medico-chirurgica 20040801 |
| Effect of aerosolized milrinone during drug-induced pulmonary hypertension in lambs. | Pharmacological research 20040701 |
| Enhanced vasodilatory responses to milrinone in catecholamine-precontracted small pulmonary arteries. | Anesthesia and analgesia 20040601 |
| New positive inotropic agents in the treatment of left ventricular dysfunction. | Italian heart journal : official journal of the Italian Federation of Cardiology 20040601 |
| Pharmacological assessment of composite arterial conduits using angiography early in the postoperative period. | The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi 20040601 |
| [Differences in outcome in patients with poor grade subarachnoid hemorrhage (WFNS grade IV and V): according to the perioperative management against vasospasm]. | No shinkei geka. Neurological surgery 20040601 |
| A rational approach for the treatment of acute heart failure: current strategies and future options. | Current opinion in cardiology 20040501 |
| Phosphodiesterase-3 inhibition prevents the increase in pulmonary vascular resistance following inhaled nitric oxide withdrawal in lambs. | Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20040501 |
| High and low gain switches for regulation of cAMP efflux concentration: distinct roles for particulate GC- and soluble GC-cGMP-PDE3 signaling in rabbit atria. | Circulation research 20040416 |
| Analysis of the effects of phosphodiesterase type 3 and 4 inhibitors in cerebral arteries. | European journal of pharmacology 20040405 |
| Haemodynamic effects of a milrinone infusion without a bolus in patients undergoing off-pump coronary artery bypass graft surgery. | Anaesthesia 20040401 |
| Milrinone improves lung compliance. | Acta anaesthesiologica Scandinavica 20040401 |
| Inotropes improve right heart function in patients undergoing aortic valve replacement for aortic stenosis. | Anesthesia and analgesia 20040401 |
| Home continuous positive inotropic infusion as a bridge to cardiac transplantation in patients with end-stage heart failure. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20040401 |
| Milrinone and nitric oxide: combined effect on pulmonary artery pressures after cardiopulmonary bypass in children. | Journal of cardiothoracic and vascular anesthesia 20040401 |
| Effects of levosimendan and milrinone on oxygen consumption in isolated guinea-pig heart. | Journal of cardiovascular pharmacology 20040401 |
| Bovine cumulus cell-oocyte gap junctional communication during in vitro maturation in response to manipulation of cell-specific cyclic adenosine 3',5'-monophosophate levels. | Biology of reproduction 20040301 |
| [Inotropic therapy in heart failure: general aspects and clinical results]. | Medicina clinica 20040227 |
| Dobutamine-related asthma in a patient awaiting cardiac transplantation: the eosinophilic dilemma. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20040201 |
| Pulmonary responses to selective phosphodiesterase-5 and phosphodiesterase-3 inhibitors. | Chest 20040201 |
| A population pharmacokinetic analysis of milrinone in pediatric patients after cardiac surgery. | Journal of pharmacokinetics and pharmacodynamics 20040201 |
| Inhaled milrinone for the improvement of contractility of fatigued diaphragm in dogs: a dose-ranging study. | Pulmonary pharmacology & therapeutics 20040101 |
| Need for hospice and palliative care services in patients with end-stage heart failure treated with intermittent infusion of inotropes. | Clinical cardiology 20040101 |
| Beneficial effects of early initiation of vasoactive agents in patients with acute decompensated heart failure. | Reviews in cardiovascular medicine 20040101 |
| Milrinone facilitates resuscitation from cardiac arrest and attenuates postresuscitation myocardial dysfunction. | Circulation 20031216 |
| Case studies in heart failure. | Critical care nursing clinics of North America 20031201 |
| Negative functional effects of cyclic GMP are altered by cyclic AMP phosphodiesterases in rabbit cardiac myocytes. | European journal of pharmacology 20031114 |
| Synthesis and pharmacological characterization of functionalized 2-pyridones structurally related to the cardiotonic agent milrinone. | Bioorganic & medicinal chemistry 20031103 |
| Prophylactic milrinone during OPCAB of posterior vessels: implication in angina patients taking beta-blockers. | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20031101 |
| Milrinone, a selective phosphodiesterase 3 inhibitor, stimulates lipolysis, endogenous glucose production, and insulin secretion. | Metabolism: clinical and experimental 20031101 |
| Anesthetic management for implantation of the Jarvik 2000 left ventricular assist system. | Anesthesia and analgesia 20031001 |
| Critical care in cardiovascular medicine. | Current opinion in pediatrics 20031001 |
| Milrinone attenuates the negative inotropic effects of landiolol in halothane-anesthetized dogs. | Canadian journal of anaesthesia = Journal canadien d'anesthesie 20031001 |
| Adenosine receptors and phosphodiesterase inhibitors stimulate Cl- secretion in Calu-3 cells. | American journal of respiratory cell and molecular biology 20030901 |
| Usefulness of anemia as a predictor of death and rehospitalization in patients with decompensated heart failure. | The American journal of cardiology 20030901 |
| Role of cyclic nucleotide phosphodiesterase isoforms in cAMP compartmentation following beta2-adrenergic stimulation of ICa,L in frog ventricular myocytes. | The Journal of physiology 20030815 |
| Effect of nesiritide versus milrinone in the treatment of acute decompensated heart failure. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20030815 |
| Effects of preemptive therapy with milrinone or amrinone on perioperative platelet function and haemostasis in patients undergoing coronary bypass grafting. | Platelets 20030801 |
| Regulation of the cAMP-elevating effects of isoproterenol and forskolin in cardiac myocytes by treatments that cause increases in cAMP. | Biochemical and biophysical research communications 20030718 |
| Effect of milrinone on vecuronium-induced neuromuscular block. | Anaesthesia 20030701 |
| Milrinone improves lung compliance in patients receiving mechanical ventilation for cardiogenic pulmonary edema. | Acta anaesthesiologica Scandinavica 20030701 |
| Comparative actions of diazepam and other phosphodiesterase inhibitors on the effects of noradrenaline in rat myocardium. | Pharmacology & toxicology 20030701 |
| Milrinone in meningococcal sepsis. | Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20030701 |
| [The use of milrinone in a patient with mitral regurgitation and severe pulmonary hypertension: a case report]. | Masui. The Japanese journal of anesthesiology 20030701 |
| Effects of sildenafil (viagra) on human myocardial contractility, in vitro arrhythmias, and tension of internal mammaria arteries and saphenous veins. | Journal of cardiovascular pharmacology 20030501 |
| Sustained use of nesiritide to aid in bridging to heart transplant. | Clinical cardiology 20030501 |
| Vasospasm-induced stroke in a varsity athlete secondary to ephedrine ingestion. | Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine 20030501 |
| Morbidity and mortality of UNOS status 1B cardiac transplant candidates at home. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20030401 |
| Possible contribution of the sarcoplasmic reticulum Ca(2+) pump function to electrical and mechanical alternans. | Journal of electrocardiology 20030401 |
| In vivo effects of phosphodiesterase III inhibitors on glucose metabolism and insulin sensitivity. | Journal of the Chinese Medical Association : JCMA 20030401 |
| The effects of selective phosphodiesterase III and V inhibitors on adrenergic and non-adrenergic, non-cholinergic relaxation responses of guinea-pig pulmonary arteries. | Autonomic & autacoid pharmacology 20030401 |
| Heart failure etiology and response to milrinone in decompensated heart failure: results from the OPTIME-CHF study. | Journal of the American College of Cardiology 20030319 |
| Inhibition and facilitation by pimobendan, a calcium sensitizer, of catecholamine secretion from bovine adrenal chromaffin cells. | Journal of pharmacological sciences 20030301 |
| Role of nonglycosidic inotropic agents: indications, ethics, and limitations. | The Medical clinics of North America 20030301 |
| Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease. | Circulation 20030225 |
| Current medical treatment for the exacerbation of chronic heart failure resulting in hospitalization. | American heart journal 20030201 |
| A bridge for the 21st century in heart transplantation? | American heart journal 20030201 |
| Comparison of dobutamine versus milrinone therapy in hospitalized patients awaiting cardiac transplantation: a prospective, randomized trial. | American heart journal 20030201 |
| New milrinone analogues: in vitro study of structure-activity relationships for positive inotropic effect, antagonism towards endogenous adenosine, and inhibition of cardiac type III phosphodiesterase. | Naunyn-Schmiedeberg's archives of pharmacology 20030201 |
| Dopamine stabilizes milrinone-induced changes in heart rate and arterial pressure during anaesthesia with isoflurane. | European journal of anaesthesiology 20030201 |
| Clinical outcomes in patients on beta-blocker therapy admitted with worsening chronic heart failure. | The American journal of cardiology 20030115 |
| Effects of epinephrine and phosphodiesterase III inhibitors on bupivacaine-induced myocardial depression in guinea-pig papillary muscle. | British journal of anaesthesia 20030101 |
| Anti-thrombotic effect of milrinone is caused by inhibition of calcium release from the dense tubular system in human platelets. | Acta anaesthesiologica Scandinavica 20030101 |
| Involvement of cyclic AMP-mediated pathway in neural release of noradrenaline in canine isolated mesenteric artery and vein. | Cardiovascular research 20030101 |
| OPTIME in CHF trial: rethinking the use of inotropes in the management of worsening chronic heart failure resulting in hospitalization. | European journal of heart failure 20030101 |
| Intravenous milrinone in treatment of advanced congestive heart failure. | Texas Heart Institute journal 20030101 |
| Milrinone. | Neonatal network : NN 20030101 |
| AQP3, p-AQP2, and AQP2 expression is reduced in polyuric rats with hypercalcemia: prevention by cAMP-PDE inhibitors. | American journal of physiology. Renal physiology 20021201 |
| Interaction of sildenafil with cAMP-mediated vasodilation in vivo. | Hypertension (Dallas, Tex. : 1979) 20021101 |
| Dopamine may preserve the myocardial oxygen balance better than dobutamine when administered with milrinone. | Canadian journal of anaesthesia = Journal canadien d'anesthesie 20021101 |
| Continuous milrinone infusion during preoperative anti-inflammatory therapy in inflammatory aortic aneurysm complicating severe congestive heart failure. | Heart and vessels 20021101 |
| Postoperative junctional ectopic tachycardia in children: incidence, risk factors, and treatment. | The Annals of thoracic surgery 20021101 |
| Myocardial ischaemia in patients with impaired left ventricular function undergoing coronary artery bypass grafting--milrinone versus nifedipin. | European journal of anaesthesiology 20021101 |
| Successful treatment of chronic pulmonary thromboembolism by long-term intermittent administration of milrinone, a phosphodiesterase-ill inhibitor. | Internal medicine (Tokyo, Japan) 20021101 |
| Comparison of the cardiovascular effects of intracellular cyclic adenosine 3',5'-monophosphate (cAMP)-modulating agents in isoflurane-anesthetized cats. | The Journal of veterinary medical science 20021101 |
| Differential effects of amrinone and milrinone upon myocardial inflammatory signaling. | Circulation 20020924 |
| Identification of interaction sites of cyclic nucleotide phosphodiesterase type 3A with milrinone and cilostazol using molecular modeling and site-directed mutagenesis. | Molecular pharmacology 20020901 |
| Megadose of milrinone as an alternative to extracorporeal membrane oxygenation for treatment of graft failure early after cardiac transplantation. | The Journal of thoracic and cardiovascular surgery 20020901 |
| Comparison of the effects of cilostazol and milrinone on cAMP-PDE activity, intracellular cAMP and calcium in the heart. | Cardiovascular drugs and therapy 20020901 |
| Presence of cyclic nucleotide phosphodiesterases PDE1A, existing as a stable complex with calmodulin, and PDE3A in human spermatozoa. | Biology of reproduction 20020801 |
| Acute renal failure secondary to milrinone in a patient with cardiac amyloidosis. | American journal of kidney diseases : the official journal of the National Kidney Foundation 20020801 |
| Phosphodiesterase 3 inhibitors selectively block the spontaneous resumption of meiosis by macaque oocytes in vitro. | Human reproduction (Oxford, England) 20020801 |
| [Effects of recombinant human brain natriuretic peptide and milrinone on cardiac hemodynamics and renal function in anesthetized dog]. | Yao xue xue bao = Acta pharmaceutica Sinica 20020701 |
| Effects of milrinone on hemodynamics and regional blood flow in the hypoxic dog. | The Journal of veterinary medical science 20020601 |
| Effects of phosphodiesterase III inhibition on length-dependent regulation of myocardial function in coronary surgery patients. | British journal of anaesthesia 20020601 |
| Relaxation induced by milrinone and rolipram in human penile arteries and veins. | European journal of pharmacology 20020524 |
| Novel use of a short-acting intravenous beta blocker in combination with inotropic therapy as a bridge to chronic oral beta blockade in patients with advanced heart failure. | Clinical cardiology 20020501 |
| Differential regulation of human platelet responses by cGMP inhibited and stimulated cAMP phosphodiesterases. | Thrombosis and haemostasis 20020501 |
| Differential effects of specific phosphodiesterase isoenzyme inhibitors on bovine oocyte meiotic maturation. | Developmental biology 20020415 |
| Positive inotropic drug infusions for patients with heart failure: current controversies and best practice. | Home healthcare nurse 20020401 |
| Short-term intravenous milrinone for acute exacerbation of chronic heart failure: a randomized controlled trial. | JAMA 20020327 |
| Treatment of acute heart failure: out with the old, in with the new. | JAMA 20020327 |
| Physical compatibility of milrinone lactate injection with intravenous drugs commonly used in the pediatric intensive care unit. | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20020301 |
| Involvement of phosphodiesterase isozymes in osteoblastic differentiation. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20020201 |
| Milrinone increases middle cerebral artery blood flow velocity after cardiopulmonary bypass. | Journal of cardiothoracic and vascular anesthesia 20020201 |
| Activation of protein kinase A by nitric oxide in cultured dorsal root ganglion neurites of the rat, examined by a fluorescence probe, ARII. | Neuroscience letters 20020118 |
| The efficacy of preemptive Milrinone or Amrinone therapy in patients undergoing coronary artery bypass grafting. | Anesthesia and analgesia 20020101 |
| Prophylactic intravenous use of milrinone after cardiac operation in pediatrics (PRIMACORP) study. Prophylactic Intravenous Use of Milrinone After Cardiac Operation in Pediatrics. | American heart journal 20020101 |
| Effects of milrinone for right ventricular failure after left ventricular assist device implantation. | Heart and vessels 20020101 |
| Intravenous milrinone in cardiac surgery. | The Annals of thoracic surgery 20020101 |
| Symptomatic improvement in patients treated with intermittent infusion of inotropes: a double-blind placebo controled pilot study. | Journal of medicine 20020101 |
| Natriuretic peptides like NO facilitate cardiac vagal neurotransmission and bradycardia via a cGMP pathway. | American journal of physiology. Heart and circulatory physiology 20011201 |
| Comparison of dobutamine-based and milrinone-based therapy for advanced decompensated congestive heart failure: Hemodynamic efficacy, clinical outcome, and economic impact. | American heart journal 20011201 |
| The additive pulmonary vasodilatory effects of inhaled prostacyclin and inhaled milrinone in postcardiac surgical patients with pulmonary hypertension. | Anesthesia and analgesia 20011201 |
| Milrinone versus dobutamine in heart failure subjects treated chronically with carvedilol. | International journal of cardiology 20011201 |
| Comparison of milrinone versus nitroglycerin, alone and in combination, on grafted internal mammary artery flow after cardiopulmonary bypass: effects of alpha-adrenergic stimulation. | Journal of cardiothoracic and vascular anesthesia 20011201 |
| [The pulmonary vasodilatory effect of inhaled prostacyclin and milrinone in heart]. | Revista espanola de anestesiologia y reanimacion 20011201 |
| Interplay between inhibition of adenosine uptake and phosphodiesterase type 3 on cardiac function by cilostazol, an agent to treat intermittent claudication. | Journal of cardiovascular pharmacology 20011101 |
| Synergistic interaction of diazepam with 3',5'-cyclic adenosine monophosphate-elevating agents on rat aortic rings. | European journal of pharmacology 20011005 |
| The evolving management of acute right-sided heart failure in cardiac transplant recipients. | Journal of the American College of Cardiology 20011001 |
| Carvedilol titration in patients with congestive heart failure receiving inotropic therapy. | American heart journal 20010901 |
| Nitric oxide-cGMP pathway facilitates acetylcholine release and bradycardia during vagal nerve stimulation in the guinea-pig in vitro. | The Journal of physiology 20010901 |
| Effects of milrinone on left ventricular end-systolic pressure-volume relationship of rat hearts in situ. | Clinical and experimental pharmacology & physiology 20010901 |
| Cardioprotective effect afforded by transient exposure to phosphodiesterase III inhibitors: the role of protein kinase A and p38 mitogen-activated protein kinase. | Circulation 20010807 |
| A conscious-rabbit model to study vardenafil hydrochloride and other agents that influence penile erection. | International journal of impotence research 20010801 |
| The effects of alpha-human atrial natriuretic peptide and milrinone on pial vessels during blood-brain barrier disruption in rabbits. | Anesthesia and analgesia 20010701 |
| Milrinone echocardiographic viability test: a pilot study. | Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 20010701 |
| Inhibition of phosphodiesterase type III before aortic cross-clamping preserves intramyocardial cyclic adenosine monophosphate during cardiopulmonary bypass. | Anesthesia and analgesia 20010601 |
| Modulation of thapsigargin-induced calcium mobilisation by cyclic AMP-elevating agents in human lymphocytes is insensitive to the action of the protein kinase A inhibitor H-89. | Cellular signalling 20010601 |
| A randomized multicenter study comparing the efficacy and safety of intravenous milrinone and intravenous nitroglycerin in patients with advanced heart failure. | Journal of cardiac failure 20010601 |
| Comparison of the hemodynamic effects of milrinone with dobutamine in patients after cardiac surgery. | Journal of cardiothoracic and vascular anesthesia 20010601 |
| The role of cGMP hydrolysing phosphodiesterases 1 and 5 in cerebral artery dilatation. | European journal of pharmacology 20010518 |
| Improved survival with simendan after experimental myocardial infarction in rats. | European journal of pharmacology 20010511 |
| Combined phosphodiesterase inhibition and beta-blockade in the GI104313, decreases ischemia-induced arrhythmias in the rat. | Canadian journal of anaesthesia = Journal canadien d'anesthesie 20010501 |
| Local anesthetic toxicity and milrinone. | Canadian journal of anaesthesia = Journal canadien d'anesthesie 20010501 |
| Effect of low-dose milrinone on gastric intramucosal pH and systemic inflammation after hypothermic cardiopulmonary bypass. | Journal of cardiothoracic and vascular anesthesia 20010401 |
| Milrinone for the treatment of cerebral vasospasm after subarachnoid hemorrhage: report of seven cases. | Neurosurgery 20010401 |
| [The effects of milrinone on hemodynamics in patients undergoing cardiac surgery]. | Masui. The Japanese journal of anesthesiology 20010401 |
| Diazepam and rolipram differentially inhibit cyclic AMP-specific phosphodiesterases PDE4A1 and PDE4B3 in the mouse. | Biochimica et biophysica acta 20010319 |
| Pharmacodynamic effects of milrinone with and without a bolus loading infusion. | American heart journal 20010201 |
| Physiological increase in plasma leptin markedly inhibits insulin secretion in vivo. | Diabetes 20010201 |
| Slow induction of milrinone after coronary artery bypass grafting. | Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 20010201 |
| Iloprost inhibits inositol-1,4,5-trisphosphate-mediated calcium mobilization stimulated by angiotensin II in cultured preglomerular vascular smooth muscle cells. | Journal of the American Society of Nephrology : JASN 20010101 |
| Experimental study of a type 3 phosphodiesterase inhibitor on liver graft function. | The British journal of surgery 20010101 |
| [Effect of colforsin daropate hydrochloride after cardiopulmonary bypass]. | Masui. The Japanese journal of anesthesiology 20010101 |
| Comparison of systemic vasodilators: effects on flow in internal mammary and radial arteries. | The Annals of thoracic surgery 20010101 |
| Inhibition of lung phosphodiesterase improves responsiveness to inhaled nitric oxide in isolated-perfused lungs from rats challenged with endotoxin. | Intensive care medicine 20010101 |
| New therapeutic choices in the management of acute congestive heart failure. | Reviews in cardiovascular medicine 20010101 |
| Hemodynamic effects of milrinone during weaning from cardiopulmonary bypass: comparison of patients with a low and high prebypass cardiac index. | Journal of cardiothoracic and vascular anesthesia 20000801 |
| Vasopressin in the treatment of milrinone-induced hypotension in severe heart failure. | The American journal of cardiology 20000215 |
| [The effects of intravenous milrinone for the patient undergoing CABG]. | Kyobu geka. The Japanese journal of thoracic surgery 20000201 |
| Vasopressin as an alternative to norepinephrine in the treatment of milrinone-induced hypotension. | Critical care medicine 20000101 |
| The use of milrinone in pre-transplant assessment of patients with congestive heart failure and pulmonary hypertension. | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 19990401 |
| Milrinone, a phosphodiesterase inhibitor, suppresses intimal thickening after photochemically induced endothelial injury in the mouse femoral artery. | Atherosclerosis 19990101 |
| A multicenter, randomized, blind comparison of amrinone with milrinone after elective cardiac surgery. | Anesthesia and analgesia 19980401 |
| Treatment of milrinone-associated tachycardia with beta-blockers. | Canadian journal of anaesthesia = Journal canadien d'anesthesie 19980101 |
| [Differential therapy of cardiogenic shock with dopamine/milrinone in comparison with dopamine/dobutamine]. | Zeitschrift fur Kardiologie 19961101 |
| Hemodynamic effects of i.v. milrinone lactate in pediatric patients with septic shock. A prospective, double-blinded, randomized, placebo-controlled, interventional study. | Chest 19960501 |
| Milrinone: systemic and pulmonary hemodynamic effects in neonates after cardiac surgery. | Critical care medicine 19951101 |
| Comparative cardiac effects of milrinone and sodium nitroprusside in conscious rats. | Drug and chemical toxicology 19950201 |
| Electrophysiologic and proarrhythmic effects of intravenous inotropic agents. | Progress in cardiovascular diseases 19950101 |
| Combined use of glucagon and milrinone may not be preferable for severe propranolol poisoning in the canine model. | Journal of toxicology. Clinical toxicology 19950101 |
| Milrinone versus glucagon: comparative hemodynamic effects in canine propranolol poisoning. | Journal of toxicology. Clinical toxicology 19940101 |
| Effects of milrinone on left ventricular remodeling after acute myocardial infarction. | Circulation 19910801 |
| Milrinone inhibits sympathetic-mediated tachycardia by a postjunctional action independent of cyclic AMP. | Journal of cardiovascular pharmacology 19910701 |
| Phosphodiesterase III inhibition or adrenoreceptor stimulation: milrinone as an alternative to dobutamine in the treatment of severe heart failure. | American heart journal 19910601 |
| Beneficial hemodynamic effects of two weeks' milrinone treatment in conscious rats with heart failure. | European journal of pharmacology 19900717 |
| Cardiac and hemodynamic profile of the new cardiotonic agent, DPI 201-106, in the conscious dog. | European journal of pharmacology 19890608 |
| Acute effects of milrinone on the electrocardiogram and the cardiac hemodynamics of rats with pressure overload-induced congestive heart failure. | Archives internationales de pharmacodynamie et de therapie 19890101 |
| Differential effects of milrinone and dobutamine on right ventricular preload, afterload and systolic performance in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. | The American journal of cardiology 19871201 |
| [Central and regional vascular hemodynamics of milrinone in experimental heart failure: comparison with captopril and dobutamine]. | Zeitschrift fur Kardiologie 19870801 |
| Positive inotropic and vasodilator actions of milrinone in patients with severe congestive heart failure. Dose-response relationships and comparison to nitroprusside. | The Journal of clinical investigation 19850201 |
| The new inotropic phosphodiesterase inhibitors. | Archives internationales de physiologie et de biochimie 19841101 |
| The search for a digitalis substitute II milrinone (Win 47203). Its action on the heart-lung preparation of the dog. | Life sciences 19831031 |
| Cardiotonic activity of milrinone, a new and potent cardiac bipyridine, on the normal and failing heart of experimental animals. | Journal of cardiovascular pharmacology 19830101 |
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