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1001645-58-4 | 2-Quinoxalinecarboxamide, N-[2-[3-(1-piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-, hydrochloride (1:?)

CAS No: 1001645-58-4 Catalog No: AG00014N MDL No:

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Catalog Number:
Chemical Name:
2-Quinoxalinecarboxamide, N-[2-[3-(1-piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-, hydrochloride (1:?)
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Title Journal
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Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20171001
Protective effects of SRT1720 via the HNF1α/FXR signalling pathway and anti-inflammatory mechanisms in mice with estrogen-induced cholestatic liver injury. Toxicology letters 20161215
Dual Targeting of CDK4 and ARK5 Using a Novel Kinase Inhibitor ON123300 Exerts Potent Anticancer Activity against Multiple Myeloma. Cancer research 20160301
Concurrent acetylation of FoxO1/3a and p53 due to sirtuins inhibition elicit Bim/PUMA mediated mitochondrial dysfunction and apoptosis in berberine-treated HepG2 cells. Toxicology and applied pharmacology 20160115
Reverse chemomodulatory effects of the SIRT1 activators resveratrol and SRT1720 in Ewing's sarcoma cells: resveratrol suppresses and SRT1720 enhances etoposide- and vincristine-induced anticancer activity. Journal of cancer research and clinical oncology 20160101
The Histone Deacetylase Sirtuin 1 Is Reduced in Systemic Sclerosis and Abrogates Fibrotic Responses by Targeting Transforming Growth Factor β Signaling. Arthritis & rheumatology (Hoboken, N.J.) 20150501
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SRT1720 induces mitochondrial biogenesis and rescues mitochondrial function after oxidant injury in renal proximal tubule cells. The Journal of pharmacology and experimental therapeutics 20100501
Sirt1 activation protects the mouse renal medulla from oxidative injury. The Journal of clinical investigation 20100401
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Metabolic engineering of resveratrol and other longevity boosting compounds. BioFactors (Oxford, England) 20100101
Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice. American journal of physiology. Endocrinology and metabolism 20091101
Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3. Protein science : a publication of the Protein Society 20090301
Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo. BMC systems biology 20090101
A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature 20081113
Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell metabolism 20081101
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 20071129

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